Updates after 2023: The Functional Status for the variants are updated based on updates in the ClinGen Evidence Repository (https://erepo.genome.network/evrepo/ui/summary/affiliation/50038) or updates from the ClinGen Malignant Hyperthermia Susceptibility Variant Curation Expert Panel, ClinGen (https://www.ncbi.nlm.nih.gov/clinvar/?term=%22ClinGen%20Malignant%20Hyperthermia%20Susceptibility%20Variant%20Curation%20Expert%20Panel%2C%20ClinGen%22[submitter]+AND+%22RYR1%22[gene])in ClinVar. If Classification assignments not agree between the two sources, the classifiation with the more current date is used. See Change log for dates and variants.