--
--

\restrict 417wzl7ZoEQHCBLTnyE5SqMH3LSkHnZDIeYXy4W0EG6t5wg1imnhLAIEbsxbz3P


SET transaction_timeout = 0;
SELECT pg_catalog.set_config('search_path', '', false);

--
-- Name: cpic; Type: SCHEMA; Schema: -; Owner: -
--

CREATE SCHEMA cpic;


--
-- Name: increment_version(); Type: FUNCTION; Schema: cpic; Owner: -
--

CREATE FUNCTION cpic.increment_version() RETURNS trigger
    LANGUAGE plpgsql
    AS $$
BEGIN
  new.version := new.version + 1;
  return new;
END;
$$;


--
-- Name: pharmgkb_guideline_alleles(text); Type: FUNCTION; Schema: cpic; Owner: -
--

CREATE FUNCTION cpic.pharmgkb_guideline_alleles(pharmgkbdrugid text) RETURNS TABLE(genesymbol text, chr text, lookupmethod text, alleles text[])
    LANGUAGE sql STABLE
    AS $$
select
    a.genesymbol,
    g.chr,
    g.lookupmethod,
    array_agg(distinct a.name order by a.name) as alleles
from allele a join gene g on a.genesymbol=g.symbol
where
    a.clinicalfunctionalstatus is not null
    and g.lookupmethod!='ALLELE_STATUS'
    and a.genesymbol in (
        select distinct jsonb_object_keys(p.lookupkey) as genes
        from recommendation p join guideline g on p.guidelineid = g.id join drug d on p.drugid=d.drugid
        where d.pharmgkbid=pharmgkbdrugid
    )
group by a.genesymbol, g.chr, g.lookupmethod
union all
select
    g.symbol as genesymbol,
    g.chr,
    g.lookupmethod,
    array_agg(distinct a.value order by a.value) as alleles
from
    recommendation r
    join drug d on r.drugid = d.drugid,
    jsonb_each_text(r.lookupkey) a
    join gene g on (a.key=g.symbol)
where
    r.allelestatus is not null
    and g.lookupmethod='ALLELE_STATUS'
    and d.pharmgkbid=pharmgkbdrugid
    and upper(a.value) != 'NO RESULT'
group by g.symbol, g.chr, g.lookupmethod
$$;


--
-- Name: FUNCTION pharmgkb_guideline_alleles(pharmgkbdrugid text); Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON FUNCTION cpic.pharmgkb_guideline_alleles(pharmgkbdrugid text) IS 'For a given PharmGKB drug ID, list the alleles that are options for looking up recommendations';


--
-- Name: pharmgkb_guideline_recommendation(text, text); Type: FUNCTION; Schema: cpic; Owner: -
--

CREATE FUNCTION cpic.pharmgkb_guideline_recommendation(drugidarg text, lookupkeyarg text) RETURNS TABLE(drugname text, recommendationid integer, implications jsonb, drugrecommendation text, classification text, phenotypes jsonb, activityscore jsonb, allelestatus jsonb, population text, comments text)
    LANGUAGE sql STABLE
    AS $$
select
    d.name as drugname,
    r.id as recommendationid,
    r.implications,
    r.drugrecommendation,
    r.classification,
    r.phenotypes,
    r.activityscore,
    r.allelestatus,
    r.population,
    r.comments
from recommendation r join drug d on r.drugid = d.drugid join guideline g on r.guidelineid = g.id
where lookupkey <@ (
    select jsonb_object_agg(a.key, coalesce(d.lookupkey -> a.key, a.value)) as lookup
    from
        json_each(lookupkeyArg::json) a
            left join diplotype d on (d.diplotypekey=jsonb_build_object(a.key, a.value))
)
  and d.pharmgkbid=drugidArg
$$;


--
-- Name: FUNCTION pharmgkb_guideline_recommendation(drugidarg text, lookupkeyarg text); Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON FUNCTION cpic.pharmgkb_guideline_recommendation(drugidarg text, lookupkeyarg text) IS 'For a given PharmGKB guideline and genotype lookup JSON key, give the matching recommendations';


--
-- Name: pharmgkb_recommendation(text); Type: FUNCTION; Schema: cpic; Owner: -
--

CREATE FUNCTION cpic.pharmgkb_recommendation(lookupkeyarg text) RETURNS TABLE(drugname text, drugid text, recommendationid integer, implications jsonb, drugrecommendation text, classification text, phenotypes jsonb, activityscore jsonb, allelestatus jsonb, population text, comments text, guidelineurl text)
    LANGUAGE sql STABLE
    AS $$
select
    d.name as drugname,
    d.pharmgkbid as drugid,
    r.id as recommendationid,
    r.implications,
    r.drugrecommendation,
    r.classification,
    r.phenotypes,
    r.activityscore,
    r.allelestatus,
    r.population,
    r.comments,
    g.url as guidelineurl
from recommendation r join drug d on r.drugid = d.drugid join guideline g on r.guidelineid = g.id
where lookupkey <@ (
    select jsonb_object_agg(a.key, coalesce(d.lookupkey -> a.key, a.value)) as lookup
    from
        json_each(lookupKeyArg::json) a
            left join diplotype d on (d.diplotypekey=jsonb_build_object(a.key, a.value))
)
$$;


--
-- Name: FUNCTION pharmgkb_recommendation(lookupkeyarg text); Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON FUNCTION cpic.pharmgkb_recommendation(lookupkeyarg text) IS 'For a given genotype lookup JSON key, give the matching recommendations for all available drugs';


--
-- Name: cpic_id; Type: SEQUENCE; Schema: cpic; Owner: -
--

CREATE SEQUENCE cpic.cpic_id
    START WITH 110000
    INCREMENT BY 1
    NO MINVALUE
    NO MAXVALUE
    CACHE 1;




--
-- Name: drug; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.drug (
    drugid character varying(20) NOT NULL,
    name text NOT NULL,
    clinpgxid character varying(20),
    rxnormid character varying(20),
    drugbankid character varying(20),
    atcid text[],
    umlscui character varying(20),
    flowchart text,
    version integer DEFAULT 1,
    guidelineid integer
);


--
-- Name: TABLE drug; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.drug IS 'A clinically-used drug.';


--
-- Name: COLUMN drug.drugid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.drug.drugid IS 'A unique identifier for this drug in the form "source:id" where source is some outside knowledge resource and id is their identifier, primary key';


--
-- Name: COLUMN drug.name; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.drug.name IS 'The generic name for this drug, lower-cased, required';


--
-- Name: COLUMN drug.clinpgxid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.drug.clinpgxid IS 'The ClinPGx ID for this drug, optional';


--
-- Name: COLUMN drug.rxnormid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.drug.rxnormid IS 'The RxNorm ID for this drug, optional';


--
-- Name: COLUMN drug.drugbankid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.drug.drugbankid IS 'The DrugBank ID for this drug, optional';


--
-- Name: COLUMN drug.atcid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.drug.atcid IS 'One or more ATC IDs for this drug in an array, optional';


--
-- Name: COLUMN drug.umlscui; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.drug.umlscui IS 'The UMLS Concept Unique ID for this drug, optional';


--
-- Name: COLUMN drug.flowchart; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.drug.flowchart IS 'URL for the flow chart image of this drug';


--
-- Name: COLUMN drug.guidelineid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.drug.guidelineid IS 'The guideline this drug is part of a guideline, null means not a part of any guideline';


--
-- Name: guideline; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.guideline (
    id integer DEFAULT nextval('cpic.cpic_id'::regclass) NOT NULL,
    version integer DEFAULT 1,
    name text NOT NULL,
    url text,
    genes text[],
    notesonusage text,
    clinpgxid text
);


--
-- Name: TABLE guideline; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.guideline IS 'A guideline for a drug or group of drugs';


--
-- Name: COLUMN guideline.id; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.guideline.id IS 'A synthetic numerical ID, primary key';


--
-- Name: COLUMN guideline.version; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.guideline.version IS 'The version number, iterates on modification';


--
-- Name: COLUMN guideline.name; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.guideline.name IS 'The name (title) of this guideline, required';


--
-- Name: COLUMN guideline.url; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.guideline.url IS 'The URL of this guideline on the cpicpgx.org domain, optional';


--
-- Name: COLUMN guideline.genes; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.guideline.genes IS 'The subject genes of this guideline';


--
-- Name: COLUMN guideline.notesonusage; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.guideline.notesonusage IS 'Notes about using a particular guideline within this system. This may include. You may find information here when data for a guideline seems missing or incomplete.';


--
-- Name: COLUMN guideline.clinpgxid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.guideline.clinpgxid IS 'The accession ID in ClinPGx for the guideline';


--
-- Name: recommendation; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.recommendation (
    id integer DEFAULT nextval('cpic.cpic_id'::regclass) NOT NULL,
    guidelineid integer,
    drugid character varying(20),
    implications jsonb,
    drugrecommendation text,
    classification character varying(20),
    phenotypes jsonb,
    activityscore jsonb,
    allelestatus jsonb,
    lookupkey jsonb,
    population text,
    comments text,
    version integer DEFAULT 1,
    dosinginformation boolean DEFAULT false,
    alternatedrugavailable boolean DEFAULT false,
    otherprescribingguidance boolean DEFAULT false
);


--
-- Name: TABLE recommendation; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.recommendation IS 'Recommendations for a gene result pulled from a guideline';


--
-- Name: COLUMN recommendation.id; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.recommendation.id IS 'A synthetic numerical ID, auto-assigned, primary key';


--
-- Name: COLUMN recommendation.guidelineid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.recommendation.guidelineid IS 'The guideline this recommendation appears in';


--
-- Name: COLUMN recommendation.drugid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.recommendation.drugid IS 'The drug this recommendation is for';


--
-- Name: COLUMN recommendation.implications; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.recommendation.implications IS 'Implications for phenotypic measures, this is a JSON mapping of gene to implication';


--
-- Name: COLUMN recommendation.drugrecommendation; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.recommendation.drugrecommendation IS 'Dosing or therapeutic recommendations, depending on particular drug';


--
-- Name: COLUMN recommendation.classification; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.recommendation.classification IS 'Classification of recommendations, described in supplementary meterial';


--
-- Name: COLUMN recommendation.phenotypes; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.recommendation.phenotypes IS 'Phenotypes that this recommendation applies to, this is a JSON mapping of gene to phenotype';


--
-- Name: COLUMN recommendation.activityscore; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.recommendation.activityscore IS 'Activity score that this recommendation applies to, this is a JSON mapping of gene to score value';


--
-- Name: COLUMN recommendation.allelestatus; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.recommendation.allelestatus IS 'Whether or not an allele is present, used mainly for HLA genes, and used for recommendation lookups. This is a JSON mapping of gene to allele status (positive/negative)';


--
-- Name: COLUMN recommendation.lookupkey; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.recommendation.lookupkey IS 'A key to use for finding a specific recommendation. Made of a JSON object of gene symbol to key value. The key value can be one of phenotype, activity score, or allele status depending on the gene.';


--
-- Name: COLUMN recommendation.population; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.recommendation.population IS 'The population this recommendation is applicable to';


--
-- Name: COLUMN recommendation.comments; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.recommendation.comments IS 'Optional comments about the recommendation';


--
-- Name: COLUMN recommendation.dosinginformation; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.recommendation.dosinginformation IS 'The guideline recommends a dose adjustment based on genetic variants or phenotypes (e.g. "poor metabolizers") as a primary course of action. However, the guideline may also describe extenuating circumstances where this action is not appropriate.';


--
-- Name: COLUMN recommendation.alternatedrugavailable; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.recommendation.alternatedrugavailable IS 'The guideline recommends that an alternate drug be selected for patients based on genetic variants or phenotypes (e.g. "poor metabolizers") as a primary course of action. However, the guideline may also describe extenuating circumstances where this action is not appropriate.';


--
-- Name: COLUMN recommendation.otherprescribingguidance; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.recommendation.otherprescribingguidance IS 'The guideline and other prescribing guidance not described as either dose adjustment or alternate drug.';


--
-- Name: recommendation_view; Type: VIEW; Schema: cpic; Owner: -
--

CREATE VIEW cpic.recommendation_view AS
 SELECT r.id AS recommendationid,
    r.lookupkey,
    d.name AS drugname,
    g.name AS guidelinename,
    g.url AS guidelineurl,
    r.implications,
    r.drugrecommendation,
    r.classification,
    r.phenotypes,
    r.activityscore,
    r.population,
    r.comments
   FROM ((cpic.recommendation r
     JOIN cpic.drug d ON (((r.drugid)::text = (d.drugid)::text)))
     JOIN cpic.guideline g ON ((r.guidelineid = g.id)));


--
-- Name: VIEW recommendation_view; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON VIEW cpic.recommendation_view IS 'A view to help find recommendation data when querying by the lookupKey';


--
-- Name: recommendation_lookup(text); Type: FUNCTION; Schema: cpic; Owner: -
--

CREATE FUNCTION cpic.recommendation_lookup(diplotypelookup text) RETURNS SETOF cpic.recommendation_view
    LANGUAGE sql STABLE SECURITY DEFINER
    AS $$
select * from cpic.recommendation_view where lookupkey <@ (
    select jsonb_object_agg(key, value) as lookupkey
    from (select lookupkey from cpic.diplotype where diplotypekey <@ diplotypelookup::jsonb) x,
        json_each(x.lookupkey)
)
$$;


--
-- Name: FUNCTION recommendation_lookup(diplotypelookup text); Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON FUNCTION cpic.recommendation_lookup(diplotypelookup text) IS 'This function helps translate diplotypes into recommendation data. This relies on the recommendation_view to gather and filter relevant information. The diplotypelookup parameter is a JSON object of gene symbol to JSON allele representation.';


--
-- Name: test_alert; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.test_alert (
    id integer DEFAULT nextval('cpic.cpic_id'::regclass) NOT NULL,
    population text,
    cdscontext text NOT NULL,
    genes text[],
    phenotype jsonb,
    activityscore jsonb,
    allelestatus jsonb,
    lookupkey jsonb,
    drugid character varying(20),
    alerttext text[] NOT NULL,
    version integer DEFAULT 1
);


--
-- Name: TABLE test_alert; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.test_alert IS 'Example CDS test alert language';


--
-- Name: COLUMN test_alert.id; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.test_alert.id IS 'A synthetic numerical ID, primary key';


--
-- Name: COLUMN test_alert.population; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.test_alert.population IS 'The population this test alert is applicable to: general, adult, pediatrics, unspecified';


--
-- Name: COLUMN test_alert.cdscontext; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.test_alert.cdscontext IS 'This should be either "Pre-test", "Post-test" or "No CDS". This field is non-null';


--
-- Name: COLUMN test_alert.genes; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.test_alert.genes IS 'One or more genes this test alert uses for trigger conditions';


--
-- Name: COLUMN test_alert.phenotype; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.test_alert.phenotype IS 'A JSON object of gene symbol keys to phenotype description';


--
-- Name: COLUMN test_alert.activityscore; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.test_alert.activityscore IS 'A JSON object of gene symbol keys to gene activity score';


--
-- Name: COLUMN test_alert.allelestatus; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.test_alert.allelestatus IS 'Whether or not an allele is present, used mainly for HLA genes. This is a JSON mapping of gene to allele status (positive/negative)';


--
-- Name: COLUMN test_alert.lookupkey; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.test_alert.lookupkey IS 'A key to use for finding a specific test alert. Made of a JSON object of gene symbol to key value. The key value can be one of phenotype, activity score, or allele status depending on the gene.';


--
-- Name: COLUMN test_alert.drugid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.test_alert.drugid IS 'The ID of a drug this alert text is for';


--
-- Name: COLUMN test_alert.alerttext; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.test_alert.alerttext IS 'An array of one or more pieces of alert text';


--
-- Name: test_alert_view; Type: VIEW; Schema: cpic; Owner: -
--

CREATE VIEW cpic.test_alert_view AS
 SELECT t.id AS testalertid,
    t.lookupkey,
    d.name AS drugname,
    t.population,
    t.alerttext,
    t.cdscontext
   FROM (cpic.test_alert t
     JOIN cpic.drug d ON (((t.drugid)::text = (d.drugid)::text)));


--
-- Name: VIEW test_alert_view; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON VIEW cpic.test_alert_view IS 'A view to help find test alert data when querying by the lookupKey';


--
-- Name: test_alert_lookup(text); Type: FUNCTION; Schema: cpic; Owner: -
--

CREATE FUNCTION cpic.test_alert_lookup(lookup text) RETURNS SETOF cpic.test_alert_view
    LANGUAGE sql STABLE SECURITY DEFINER
    AS $$
select * from cpic.test_alert_view where lookupkey <@ (
    select jsonb_object_agg(key, value) as lookupkey
    from (select lookupkey from cpic.diplotype where diplotypekey <@ lookup::jsonb) x,
        json_each(x.lookupkey)
)
$$;


--
-- Name: FUNCTION test_alert_lookup(lookup text); Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON FUNCTION cpic.test_alert_lookup(lookup text) IS 'This function helps translate diplotypes into test alert data. This relies on the test_alert_view to gather and filter relevant information. The lookup parameter is a JSON object of gene symbol to JSON allele representation.';


--
-- Name: allele; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.allele (
    id integer DEFAULT nextval('cpic.cpic_id'::regclass) NOT NULL,
    version integer DEFAULT 1,
    genesymbol character varying(50) NOT NULL,
    name text NOT NULL,
    functionalstatus text,
    clinicalfunctionalstatus text,
    clinicalfunctionalsubstrate text,
    activityvalue character varying(50),
    definitionid integer NOT NULL,
    citations text[],
    strength text,
    functioncomments text,
    findings text,
    frequency jsonb,
    inferredfrequency boolean DEFAULT false
);


--
-- Name: TABLE allele; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.allele IS 'An allele of a gene';


--
-- Name: COLUMN allele.id; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele.id IS 'A synthetic numerical ID, auto-assigned, primary key';


--
-- Name: COLUMN allele.version; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele.version IS 'The version number, iterates on modification';


--
-- Name: COLUMN allele.genesymbol; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele.genesymbol IS 'The HGNC symbol of the gene the allele is for, required';


--
-- Name: COLUMN allele.name; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele.name IS 'The name of this allele, required';


--
-- Name: COLUMN allele.functionalstatus; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele.functionalstatus IS 'The functional phenotype of this allele';


--
-- Name: COLUMN allele.clinicalfunctionalstatus; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele.clinicalfunctionalstatus IS 'The functional phenotype of this allele used for clinical systems';


--
-- Name: COLUMN allele.clinicalfunctionalsubstrate; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele.clinicalfunctionalsubstrate IS 'Allele clinical function substrate specificity, optional';


--
-- Name: COLUMN allele.activityvalue; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele.activityvalue IS 'Descriptor of activity score, optional';


--
-- Name: COLUMN allele.definitionid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele.definitionid IS 'The reference to the definition for this allele';


--
-- Name: COLUMN allele.citations; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele.citations IS 'An array of PubMed IDs use as citations for this functional assignment';


--
-- Name: COLUMN allele.strength; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele.strength IS 'The strength of evidence';


--
-- Name: COLUMN allele.functioncomments; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele.functioncomments IS 'Comments this functional assignment of this allele';


--
-- Name: COLUMN allele.inferredfrequency; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele.inferredfrequency IS 'Indicates (with "true") that the frequencies for this allele have been inferred by an algorithm that aggregates the frequencies for other alleles of this gene and is not based on direct data, defaults to false, should only be 1 per gene';


--
-- Name: allele_definition; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.allele_definition (
    id integer DEFAULT nextval('cpic.cpic_id'::regclass) NOT NULL,
    version integer DEFAULT 1,
    genesymbol character varying(50) NOT NULL,
    name text NOT NULL,
    pharmvarid character varying(50),
    matchesreferencesequence boolean DEFAULT false,
    structuralvariation boolean DEFAULT false
);


--
-- Name: TABLE allele_definition; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.allele_definition IS 'The definition for an allele of a gene';


--
-- Name: COLUMN allele_definition.id; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele_definition.id IS 'A synthetic numerical ID, auto-assigned, primary key';


--
-- Name: COLUMN allele_definition.genesymbol; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele_definition.genesymbol IS 'The HGNC symbol of the gene the allele is for, required';


--
-- Name: COLUMN allele_definition.name; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele_definition.name IS 'The name of this allele, required';


--
-- Name: COLUMN allele_definition.pharmvarid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele_definition.pharmvarid IS 'The PharmVar core allele ID for this allele';


--
-- Name: COLUMN allele_definition.matchesreferencesequence; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele_definition.matchesreferencesequence IS 'Indicates (with "true") the variants that define the named allele will match the reference sequence for the gene, defaults to false, should only be 1 per gene';


--
-- Name: COLUMN allele_definition.structuralvariation; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele_definition.structuralvariation IS 'Indicates whether this allele definition is a structural variant, default is false. If true, look in the pharmvarid field for the PharmVar ID that defines the structural variation.';


--
-- Name: allele_frequency; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.allele_frequency (
    alleleid integer NOT NULL,
    population integer NOT NULL,
    frequency numeric,
    label text,
    version integer DEFAULT 1
);


--
-- Name: TABLE allele_frequency; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.allele_frequency IS 'A frequency observation for a particular allele in a particular population';


--
-- Name: COLUMN allele_frequency.alleleid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele_frequency.alleleid IS 'The ID of the allele for this observation';


--
-- Name: COLUMN allele_frequency.population; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele_frequency.population IS 'The ID of the population for this observation';


--
-- Name: COLUMN allele_frequency.frequency; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele_frequency.frequency IS 'The numeric representation of this frequency';


--
-- Name: COLUMN allele_frequency.label; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele_frequency.label IS 'The textual label for this frequency, "-" means no observation made';


--
-- Name: COLUMN allele_frequency.version; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele_frequency.version IS 'The version number, iterates on modification';


--
-- Name: pair; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.pair (
    pairid integer DEFAULT nextval('cpic.cpic_id'::regclass) NOT NULL,
    genesymbol character varying(20),
    drugid character varying(20),
    guidelineid integer,
    usedforrecommendation boolean DEFAULT false,
    version integer DEFAULT 1,
    cpiclevel text NOT NULL,
    clinpgxlevel character varying(5),
    pgxtesting text,
    citations text[],
    removed boolean DEFAULT false,
    removeddate date,
    removedreason text,
    CONSTRAINT valid_cpiclevel_check CHECK ((cpiclevel = ANY (ARRAY[('A'::character varying)::text, ('A/B'::character varying)::text, ('B'::character varying)::text, ('B/C'::character varying)::text, ('C'::character varying)::text, ('C/D'::character varying)::text, ('D'::character varying)::text, ('Retired'::character varying)::text]))),
    CONSTRAINT valid_pgkblevel_check CHECK (((clinpgxlevel)::text = ANY (ARRAY[('1A'::character varying)::text, ('1B'::character varying)::text, ('2A'::character varying)::text, ('2B'::character varying)::text, ('3'::character varying)::text, ('4'::character varying)::text]))),
    CONSTRAINT valid_pmids CHECK ((array_to_string(citations, ''::text) ~ '\d+'::text)),
    CONSTRAINT valid_used_check CHECK (((NOT usedforrecommendation) OR (guidelineid IS NOT NULL)))
);


--
-- Name: TABLE pair; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.pair IS 'A pair of a gene and a drug that is notable to CPIC';


--
-- Name: COLUMN pair.pairid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair.pairid IS 'A synthetic numerical id, automatically assigned, primary key';


--
-- Name: COLUMN pair.genesymbol; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair.genesymbol IS 'The HGNC symbol of the gene in this pair, required';


--
-- Name: COLUMN pair.drugid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair.drugid IS 'The ID of the drug in this pair, required';


--
-- Name: COLUMN pair.guidelineid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair.guidelineid IS 'The ID of a guideline this pair is described in, optional';


--
-- Name: COLUMN pair.usedforrecommendation; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair.usedforrecommendation IS 'Whether the gene is used for recommendation lookup for the drug if this pair is part of a guideline, default false';


--
-- Name: COLUMN pair.version; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair.version IS 'The version number, iterates on modification';


--
-- Name: COLUMN pair.cpiclevel; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair.cpiclevel IS 'The CPIC level of this pair, required';


--
-- Name: COLUMN pair.clinpgxlevel; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair.clinpgxlevel IS 'The top level of PharmGKB Clinical Annotation for this pair, optional';


--
-- Name: COLUMN pair.pgxtesting; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair.pgxtesting IS 'The top level of PGx testing recommendation from PharmGKB label annotations, optional';


--
-- Name: COLUMN pair.citations; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair.citations IS 'The PMID citations in an array for this pair, optional';


--
-- Name: COLUMN pair.removed; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair.removed IS 'Has this pair been "removed", eg is no longer a valid pair, default false';


--
-- Name: COLUMN pair.removeddate; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair.removeddate IS 'If removed, when was this pair "removed"';


--
-- Name: COLUMN pair.removedreason; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair.removedreason IS 'If removed, why was this pair "removed"';


--
-- Name: allele_guideline_view; Type: VIEW; Schema: cpic; Owner: -
--

CREATE VIEW cpic.allele_guideline_view AS
 SELECT DISTINCT a.genesymbol,
    a.name AS allele_name,
    g.name AS guideline_name,
    g.url AS guideline_url
   FROM ((cpic.allele a
     JOIN cpic.pair p ON (((a.genesymbol)::text = (p.genesymbol)::text)))
     JOIN cpic.guideline g ON ((g.id = p.guidelineid)))
  WHERE (a.clinicalfunctionalstatus IS NOT NULL);


--
-- Name: VIEW allele_guideline_view; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON VIEW cpic.allele_guideline_view IS 'A combination of alleles and the guidelines they appear in';


--
-- Name: COLUMN allele_guideline_view.genesymbol; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele_guideline_view.genesymbol IS 'The HGNC symbol of the gene';


--
-- Name: COLUMN allele_guideline_view.allele_name; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele_guideline_view.allele_name IS 'The name of the allele';


--
-- Name: COLUMN allele_guideline_view.guideline_name; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele_guideline_view.guideline_name IS 'The name of the guideline this allele appears in';


--
-- Name: COLUMN allele_guideline_view.guideline_url; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele_guideline_view.guideline_url IS 'The URL to the guideline';


--
-- Name: allele_location_value; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.allele_location_value (
    alleledefinitionid integer NOT NULL,
    locationid integer NOT NULL,
    variantallele text NOT NULL,
    version integer DEFAULT 1
);


--
-- Name: TABLE allele_location_value; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.allele_location_value IS 'The change at a specific location for a specific allele';


--
-- Name: COLUMN allele_location_value.alleledefinitionid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele_location_value.alleledefinitionid IS 'The reference to the allele this variant is on';


--
-- Name: COLUMN allele_location_value.locationid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele_location_value.locationid IS 'The reference to the location this variant is for';


--
-- Name: COLUMN allele_location_value.variantallele; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele_location_value.variantallele IS 'The allele of this location for the allele';


--
-- Name: COLUMN allele_location_value.version; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele_location_value.version IS 'The version number, iterates on modification';


--
-- Name: change_log; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.change_log (
    date date NOT NULL,
    type text NOT NULL,
    entityid text,
    note text NOT NULL,
    version integer DEFAULT 1,
    deployedrelease text
);


--
-- Name: TABLE change_log; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.change_log IS 'A dated freeform text description of a change made to a type of information and optionally for a specific entity';


--
-- Name: COLUMN change_log.date; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.change_log.date IS 'The date the log note is applicable';


--
-- Name: COLUMN change_log.type; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.change_log.type IS 'The type of data this log message is about';


--
-- Name: COLUMN change_log.entityid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.change_log.entityid IS 'Optional, the specific entity this note is about. For example, could be a gene symbol or drug ID';


--
-- Name: COLUMN change_log.note; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.change_log.note IS 'The freeform text note about what the change was';


--
-- Name: COLUMN change_log.version; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.change_log.version IS 'The version number, iterates on modification';


--
-- Name: COLUMN change_log.deployedrelease; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.change_log.deployedrelease IS 'The release this change was deployed with';


--
-- Name: gene; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.gene (
    symbol character varying(20) NOT NULL,
    chr character varying(20),
    genesequenceid text,
    proteinsequenceid text,
    chromosequenceid text,
    mrnasequenceid text,
    hgncid text,
    ncbiid text,
    ensemblid text,
    clinpgxid text,
    frequencymethods text,
    lookupmethod text DEFAULT 'PHENOTYPE'::text,
    version integer DEFAULT 1,
    notesondiplotype text,
    url text,
    functionmethods text,
    notesonallelenaming text,
    includephenotypefrequencies boolean DEFAULT true NOT NULL,
    includediplotypefrequencies boolean DEFAULT true NOT NULL,
    CONSTRAINT gene_chr_check CHECK (((chr)::text ~ '^chr\S+$'::text)),
    CONSTRAINT gene_chromosequenceid_check CHECK ((chromosequenceid ~ '^(NC_\S+)?$'::text)),
    CONSTRAINT gene_ensemblid_check CHECK ((ensemblid ~ '^(ENSG\d+)?$'::text)),
    CONSTRAINT gene_genesequenceid_check CHECK ((genesequenceid ~ '^(NG_\S+)?$'::text)),
    CONSTRAINT gene_hgncid_check CHECK ((hgncid ~ '^(HGNC:\d+)?$'::text)),
    CONSTRAINT gene_mrnasequenceid_check CHECK ((mrnasequenceid ~ '^(NM_\S+)?$'::text)),
    CONSTRAINT gene_pharmgkbid_check CHECK ((clinpgxid ~ '^(PA\d+)?$'::text)),
    CONSTRAINT gene_proteinsequenceid_check CHECK ((proteinsequenceid ~ '^(NP_\S+)?$'::text))
);


--
-- Name: TABLE gene; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.gene IS 'Gene information with a primary key of the approved HGNC symbol for the gene. This means any gene used in the table must be approved by HGNC.';


--
-- Name: COLUMN gene.symbol; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene.symbol IS 'Approved HGNC symbol, primary key.';


--
-- Name: COLUMN gene.chr; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene.chr IS 'Chromosome symbol. In the form chr##, where ## is the number or X/Y.';


--
-- Name: COLUMN gene.genesequenceid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene.genesequenceid IS 'The RefSeq ID for the sequence that represents this gene, starts with "NG_". No version suffix.';


--
-- Name: COLUMN gene.proteinsequenceid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene.proteinsequenceid IS 'The RefSeq ID for the sequence that represents the protein product of this gene, starts with "NP_". No version suffix.';


--
-- Name: COLUMN gene.chromosequenceid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene.chromosequenceid IS 'The RefSeq ID for the sequence that represents the chromosome this gene is on, starts with "NC_". No version suffix.';


--
-- Name: COLUMN gene.mrnasequenceid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene.mrnasequenceid IS 'The RefSeq ID for the sequence that represents the translation of this gene, starts with "NM_". No version suffix.';


--
-- Name: COLUMN gene.hgncid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene.hgncid IS 'The HGNC numerical ID number for this gene prefixed by "HGNC:"';


--
-- Name: COLUMN gene.ncbiid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene.ncbiid IS 'The NCBI Gene (Entrez) ID number for this gene';


--
-- Name: COLUMN gene.ensemblid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene.ensemblid IS 'The Ensembl ID for this gene';


--
-- Name: COLUMN gene.clinpgxid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene.clinpgxid IS 'The ID for this gene in ClinPGx';


--
-- Name: COLUMN gene.frequencymethods; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene.frequencymethods IS 'Text documentation of the methods and caveats for allele frequency data';


--
-- Name: COLUMN gene.lookupmethod; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene.lookupmethod IS 'The way to lookup information about diplotypes of this gene, should use ACTIVITY_SCORE, PHENOTYPE, or ALLELE_STATUS';


--
-- Name: COLUMN gene.notesondiplotype; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene.notesondiplotype IS 'Optional notes about the diplotypes of the gene';


--
-- Name: COLUMN gene.includephenotypefrequencies; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene.includephenotypefrequencies IS 'if allele frequencies exist for this gene, whether to calculate and display phenotype-level frequencies. a true value does not imply existence frequency data';


--
-- Name: COLUMN gene.includediplotypefrequencies; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene.includediplotypefrequencies IS 'if allele frequencies exist for this gene, whether to calculate and display diplotype-level frequencies. a true value does not imply existence frequency data';


--
-- Name: change_log_view; Type: VIEW; Schema: cpic; Owner: -
--

CREATE VIEW cpic.change_log_view AS
 WITH x AS (
         SELECT gene.symbol AS entityid,
            gene.symbol AS entityname
           FROM cpic.gene
        UNION ALL
         SELECT drug.drugid AS entityid,
            drug.name AS entityname
           FROM cpic.drug
        )
 SELECT l.date,
    l.type,
    x.entityname,
    l.note,
    l.deployedrelease
   FROM (cpic.change_log l
     LEFT JOIN x ON ((l.entityid = (x.entityid)::text)));


--
-- Name: VIEW change_log_view; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON VIEW cpic.change_log_view IS 'This view of the change_log table add the entity name to make it more readable';


--
-- Name: gene_result; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.gene_result (
    id integer DEFAULT nextval('cpic.cpic_id'::regclass) NOT NULL,
    genesymbol character varying(50) NOT NULL,
    result text NOT NULL,
    activityscore text,
    ehrpriority text,
    consultationtext text,
    version integer DEFAULT 1,
    frequency jsonb
);


--
-- Name: TABLE gene_result; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.gene_result IS 'Possible phenotype values for a gene. The gene + phenotype + activity score should be unique.';


--
-- Name: COLUMN gene_result.id; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene_result.id IS 'A synthetic numerical ID, auto-assigned, primary key';


--
-- Name: COLUMN gene_result.genesymbol; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene_result.genesymbol IS 'The HGNC symbol of the gene in this pair, required';


--
-- Name: COLUMN gene_result.result; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene_result.result IS 'The result for a gene, can either be a phenotype or "allele status" depending on the lookup method for the gene (see lookupMethod in gene table), required';


--
-- Name: COLUMN gene_result.activityscore; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene_result.activityscore IS 'Activity score, optional';


--
-- Name: COLUMN gene_result.ehrpriority; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene_result.ehrpriority IS 'EHR Priority Result, optional';


--
-- Name: COLUMN gene_result.consultationtext; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene_result.consultationtext IS 'Consultation (Interpretation) Text Provided with Test Result';


--
-- Name: COLUMN gene_result.frequency; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene_result.frequency IS 'JSON map of frequencies for this gene result with keys being biogeographical groups';


--
-- Name: gene_result_diplotype; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.gene_result_diplotype (
    id integer DEFAULT nextval('cpic.cpic_id'::regclass) NOT NULL,
    functionphenotypeid integer NOT NULL,
    diplotype text NOT NULL,
    diplotypekey jsonb NOT NULL,
    frequency jsonb
);


--
-- Name: TABLE gene_result_diplotype; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.gene_result_diplotype IS 'Specific diplotypes that are associated with a gene result. This table is a child of gene_result_lookup and distantly of gene_result';


--
-- Name: COLUMN gene_result_diplotype.id; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene_result_diplotype.id IS 'A synthetic numerical ID, auto-assigned, primary key';


--
-- Name: COLUMN gene_result_diplotype.functionphenotypeid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene_result_diplotype.functionphenotypeid IS 'An ID referencing a gene_result_lookup record, required';


--
-- Name: COLUMN gene_result_diplotype.diplotype; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene_result_diplotype.diplotype IS 'A diplotype for the gene in the form Allele1/Allele2, required';


--
-- Name: COLUMN gene_result_diplotype.diplotypekey; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene_result_diplotype.diplotypekey IS 'A normalized JSON version of the diplotype for use in lookups. Should be an object with the allele names as properties and the counts as the values. Required';


--
-- Name: gene_result_lookup; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.gene_result_lookup (
    id integer DEFAULT nextval('cpic.cpic_id'::regclass) NOT NULL,
    phenotypeid integer NOT NULL,
    lookupkey jsonb NOT NULL,
    function1 text,
    function2 text,
    activityvalue1 text,
    activityvalue2 text,
    totalactivityscore text,
    description text
);


--
-- Name: TABLE gene_result_lookup; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.gene_result_lookup IS 'Gene descriptions that, when combined, link to a gene result. This table is a child of gene_result.';


--
-- Name: COLUMN gene_result_lookup.id; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene_result_lookup.id IS 'A synthetic numerical ID, auto-assigned, primary key';


--
-- Name: COLUMN gene_result_lookup.phenotypeid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene_result_lookup.phenotypeid IS 'An ID referencing the gene_result this is associated with, required';


--
-- Name: COLUMN gene_result_lookup.lookupkey; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene_result_lookup.lookupkey IS 'A normalized JSON format of the data used to lookup a diplotype. The keys of this field are either the functions, activity scores, or allele statuses depending on what the gene requires. Required.';


--
-- Name: COLUMN gene_result_lookup.function1; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene_result_lookup.function1 IS 'The first allele function';


--
-- Name: COLUMN gene_result_lookup.function2; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene_result_lookup.function2 IS 'The second allele function';


--
-- Name: COLUMN gene_result_lookup.activityvalue1; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene_result_lookup.activityvalue1 IS 'The activity score for the first allele function';


--
-- Name: COLUMN gene_result_lookup.activityvalue2; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene_result_lookup.activityvalue2 IS 'The activity score for the second allele function';


--
-- Name: COLUMN gene_result_lookup.totalactivityscore; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene_result_lookup.totalactivityscore IS 'The sum activity score for the functions';


--
-- Name: COLUMN gene_result_lookup.description; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene_result_lookup.description IS 'A description of the diplotypes associated with this phenotype';


--
-- Name: diplotype; Type: VIEW; Schema: cpic; Owner: -
--

CREATE VIEW cpic.diplotype AS
 SELECT gp.genesymbol,
    d.diplotype,
    pf.function1,
    pf.function2,
    pf.activityvalue1,
    pf.activityvalue2,
    pf.totalactivityscore,
    pf.description,
    d.diplotypekey,
    gp.result AS generesult,
    gp.ehrpriority,
    gp.consultationtext,
    json_build_object(gp.genesymbol,
        CASE
            WHEN (g.lookupmethod = 'ACTIVITY_SCORE'::text) THEN pf.totalactivityscore
            ELSE gp.result
        END) AS lookupkey
   FROM (((cpic.gene_result_diplotype d
     JOIN cpic.gene_result_lookup pf ON ((d.functionphenotypeid = pf.id)))
     JOIN cpic.gene_result gp ON ((pf.phenotypeid = gp.id)))
     JOIN cpic.gene g ON (((gp.genesymbol)::text = (g.symbol)::text)));


--
-- Name: VIEW diplotype; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON VIEW cpic.diplotype IS 'A combination of gene_result and gene_result_diplotype that allows you to easily query by diplotype and see the phenotype-related data for it';


--
-- Name: COLUMN diplotype.genesymbol; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.diplotype.genesymbol IS 'The HGNC symbol of the gene in this pair, required';


--
-- Name: COLUMN diplotype.diplotype; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.diplotype.diplotype IS 'A diplotype for the gene in the form Allele1/Allele2, required';


--
-- Name: COLUMN diplotype.function1; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.diplotype.function1 IS 'A functional assignment of one of the alleles, optional';


--
-- Name: COLUMN diplotype.function2; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.diplotype.function2 IS 'A functional assignment of one of the alleles, optional';


--
-- Name: COLUMN diplotype.activityvalue1; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.diplotype.activityvalue1 IS 'An activity value assignment of one of the alleles, optional';


--
-- Name: COLUMN diplotype.activityvalue2; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.diplotype.activityvalue2 IS 'An activity value assignment of one of the alleles, optional';


--
-- Name: COLUMN diplotype.totalactivityscore; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.diplotype.totalactivityscore IS 'The total Activity Score number, optional';


--
-- Name: COLUMN diplotype.description; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.diplotype.description IS 'The long-form description of the diplotype';


--
-- Name: COLUMN diplotype.diplotypekey; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.diplotype.diplotypekey IS 'A normalized version of the diplotype that can be used for DB lookups';


--
-- Name: COLUMN diplotype.generesult; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.diplotype.generesult IS 'The result for a gene, can either be a phenotype or "allele status" depending on the lookup method for the gene (see lookupMethod in gene table), required';


--
-- Name: COLUMN diplotype.lookupkey; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.diplotype.lookupkey IS 'A normalized version of the gene phenotype that can be used for recommendation or test alert lookup';


--
-- Name: data_progress; Type: VIEW; Schema: cpic; Owner: -
--

CREATE VIEW cpic.data_progress AS
 SELECT 'Gene'::text AS object_class,
    'Allele Definition Data'::text AS data_type,
    allele_definition.genesymbol AS object_name,
    count(*) AS n
   FROM cpic.allele_definition
  GROUP BY allele_definition.genesymbol
UNION ALL
 SELECT 'Gene'::text AS object_class,
    'Allele Functionality Data'::text AS data_type,
    a.genesymbol AS object_name,
    count(*) AS n
   FROM cpic.allele a
  WHERE (a.clinicalfunctionalstatus IS NOT NULL)
  GROUP BY a.genesymbol
UNION ALL
 SELECT 'Gene'::text AS object_class,
    'Diplotype to Phenotype Data'::text AS data_type,
    diplotype.genesymbol AS object_name,
    count(*) AS n
   FROM cpic.diplotype
  GROUP BY diplotype.genesymbol
UNION ALL
 SELECT 'Gene'::text AS object_class,
    'Frequency Data'::text AS data_type,
    a.genesymbol AS object_name,
    count(*) AS n
   FROM (cpic.allele_frequency f
     JOIN cpic.allele a ON ((f.alleleid = a.id)))
  GROUP BY a.genesymbol
UNION ALL
 SELECT 'Gene'::text AS object_class,
    'Gene CDS Data'::text AS data_type,
    gene_result.genesymbol AS object_name,
    count(*) AS n
   FROM cpic.gene_result
  WHERE (gene_result.consultationtext IS NOT NULL)
  GROUP BY gene_result.genesymbol
UNION ALL
 SELECT 'Gene'::text AS object_class,
    'Gene Phenotype Data'::text AS data_type,
    g.genesymbol AS object_name,
    count(*) AS n
   FROM (cpic.gene_result g
     JOIN cpic.gene_result_lookup pf ON ((g.id = pf.phenotypeid)))
  GROUP BY g.genesymbol
UNION ALL
 SELECT 'Gene'::text AS object_class,
    'PharmVar Allele IDs'::text AS data_type,
    a.genesymbol AS object_name,
    count(*) AS n
   FROM cpic.allele_definition a
  WHERE (a.pharmvarid IS NOT NULL)
  GROUP BY a.genesymbol
UNION ALL
 SELECT 'Drug'::text AS object_class,
    'Flowcharts'::text AS data_type,
    drug.name AS object_name,
    count(*) AS n
   FROM cpic.drug
  WHERE (drug.flowchart IS NOT NULL)
  GROUP BY drug.name
UNION ALL
 SELECT 'Drug'::text AS object_class,
    'Table 2 Recommendations'::text AS data_type,
    d.name AS object_name,
    count(DISTINCT r.id) AS n
   FROM (cpic.recommendation r
     JOIN cpic.drug d ON (((r.drugid)::text = (d.drugid)::text)))
  GROUP BY d.name
UNION ALL
 SELECT 'Drug'::text AS object_class,
    'Drug Test Alerts'::text AS data_type,
    d.name AS object_name,
    count(DISTINCT t.id) AS n
   FROM (cpic.test_alert t
     JOIN cpic.drug d ON (((t.drugid)::text = (d.drugid)::text)))
  GROUP BY d.name
UNION ALL
 SELECT 'Drug'::text AS object_class,
    'Guideline'::text AS data_type,
    d.name AS object_name,
    count(DISTINCT g.id) AS n
   FROM ((cpic.guideline g
     JOIN cpic.pair p ON ((g.id = p.guidelineid)))
     JOIN cpic.drug d ON (((p.drugid)::text = (d.drugid)::text)))
  GROUP BY d.name;


--
-- Name: file_artifact; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.file_artifact (
    id integer DEFAULT nextval('cpic.cpic_id'::regclass) NOT NULL,
    entityids text[],
    type text NOT NULL,
    filename text NOT NULL,
    url text
);


--
-- Name: TABLE file_artifact; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.file_artifact IS 'File artifact information. Each entry is a different file artifact generated by the system';


--
-- Name: COLUMN file_artifact.id; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.file_artifact.id IS 'A synthetic numerical ID, auto-assigned, primary key';


--
-- Name: COLUMN file_artifact.entityids; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.file_artifact.entityids IS 'The IDs of the entities the file is for, required';


--
-- Name: COLUMN file_artifact.type; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.file_artifact.type IS 'The type of file';


--
-- Name: COLUMN file_artifact.filename; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.file_artifact.filename IS 'The name of the file (no path)';


--
-- Name: COLUMN file_artifact.url; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.file_artifact.url IS 'The permanent URL of the current version of this file';


--
-- Name: file_artifact_history; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.file_artifact_history (
    id integer DEFAULT nextval('cpic.cpic_id'::regclass) NOT NULL,
    fileid integer NOT NULL,
    source text NOT NULL,
    changedate timestamp without time zone DEFAULT CURRENT_TIMESTAMP NOT NULL,
    changemessage text
);


--
-- Name: TABLE file_artifact_history; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.file_artifact_history IS 'History information for a related file artifact';


--
-- Name: COLUMN file_artifact_history.id; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.file_artifact_history.id IS 'A synthetic numerical ID, auto-assigned, primary key';


--
-- Name: COLUMN file_artifact_history.fileid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.file_artifact_history.fileid IS 'The ID of the related File Artifact';


--
-- Name: COLUMN file_artifact_history.source; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.file_artifact_history.source IS 'Where this history message originated from';


--
-- Name: COLUMN file_artifact_history.changedate; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.file_artifact_history.changedate IS 'The date the change was applied';


--
-- Name: COLUMN file_artifact_history.changemessage; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.file_artifact_history.changemessage IS 'A message describing the change that occurred';


--
-- Name: file_note; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.file_note (
    type text NOT NULL,
    entityid text,
    note text NOT NULL,
    ordinal integer NOT NULL,
    version integer DEFAULT 1
);


--
-- Name: TABLE file_note; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.file_note IS 'An ordered note that should appear with the type of information specified';


--
-- Name: COLUMN file_note.type; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.file_note.type IS 'The type of information this note is about';


--
-- Name: COLUMN file_note.entityid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.file_note.entityid IS 'Optional, the specific entity this note is about. For example, could be a gene symbol or drug ID';


--
-- Name: COLUMN file_note.note; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.file_note.note IS 'The freeform text note about the type/entity';


--
-- Name: COLUMN file_note.ordinal; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.file_note.ordinal IS 'The index number for ordering notes of a given type/entity';


--
-- Name: COLUMN file_note.version; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.file_note.version IS 'The version number, iterates on modification';


--
-- Name: file_status; Type: VIEW; Schema: cpic; Owner: -
--

CREATE VIEW cpic.file_status AS
 SELECT a.id,
    a.entityids,
    a.type,
    a.filename,
    a.url,
    history.latest_change
   FROM (cpic.file_artifact a
     LEFT JOIN ( SELECT h.fileid,
            max(h.changedate) AS latest_change
           FROM cpic.file_artifact_history h
          GROUP BY h.fileid) history ON ((a.id = history.fileid)))
  ORDER BY a.type, a.filename;


--
-- Name: flyway_schema_history; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.flyway_schema_history (
    installed_rank integer NOT NULL,
    version character varying(50),
    description character varying(200) NOT NULL,
    type character varying(20) NOT NULL,
    script character varying(1000) NOT NULL,
    checksum integer,
    installed_by character varying(100) NOT NULL,
    installed_on timestamp without time zone DEFAULT now() NOT NULL,
    execution_time integer NOT NULL,
    success boolean NOT NULL
);


--
-- Name: guideline_summary_view; Type: VIEW; Schema: cpic; Owner: -
--

CREATE VIEW cpic.guideline_summary_view AS
 SELECT g.name AS guideline_name,
    g.url AS guideline_url,
    array_agg(DISTINCT d.name) AS drugs,
    jsonb_agg(DISTINCT jsonb_build_object('symbol', p.genesymbol, 'url', (('https://cpicpgx.org/gene/'::text || lower((p.genesymbol)::text)) || '/'::text))) AS genes
   FROM ((cpic.guideline g
     JOIN cpic.pair p ON ((g.id = p.guidelineid)))
     JOIN cpic.drug d ON (((p.drugid)::text = (d.drugid)::text)))
  GROUP BY g.name, g.url;


--
-- Name: VIEW guideline_summary_view; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON VIEW cpic.guideline_summary_view IS 'This view lists guidelines and the genes and drugs that are associated with them';


--
-- Name: COLUMN guideline_summary_view.guideline_name; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.guideline_summary_view.guideline_name IS 'The title of the guideline';


--
-- Name: COLUMN guideline_summary_view.guideline_url; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.guideline_summary_view.guideline_url IS 'The URL of the guideline on the CPIC website';


--
-- Name: COLUMN guideline_summary_view.drugs; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.guideline_summary_view.drugs IS 'An array of drug names associated with this guideline';


--
-- Name: COLUMN guideline_summary_view.genes; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.guideline_summary_view.genes IS 'An array of gene data associated with this guideline, each object will have a symbol and a URL for the gene on the CPIC website';


--
-- Name: pair_view; Type: VIEW; Schema: cpic; Owner: -
--

CREATE VIEW cpic.pair_view AS
 SELECT p.pairid,
    p.drugid,
    d.name AS drugname,
    p.genesymbol,
    g.name AS guidelinename,
    g.url AS guidelineurl,
    p.cpiclevel,
    p.clinpgxlevel,
    p.pgxtesting,
    p.citations AS pmids,
        CASE
            WHEN (p.usedforrecommendation AND (p.guidelineid IS NOT NULL)) THEN 'Yes'::text
            WHEN ((NOT p.usedforrecommendation) AND (p.guidelineid IS NOT NULL)) THEN 'No'::text
            ELSE 'n/a'::text
        END AS usedforrecommendation,
        CASE
            WHEN (p.guidelineid IS NULL) THEN true
            ELSE false
        END AS provisional
   FROM ((cpic.pair p
     JOIN cpic.drug d ON (((p.drugid)::text = (d.drugid)::text)))
     LEFT JOIN cpic.guideline g ON ((p.guidelineid = g.id)))
  WHERE (p.removed IS FALSE);


--
-- Name: VIEW pair_view; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON VIEW cpic.pair_view IS 'This pairs view combines information from the pair, drug, and guideline tables to make a more readable view of pair data. This also limits result to pairs which have NOT been removed.';


--
-- Name: COLUMN pair_view.pairid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair_view.pairid IS 'The primary key ID of this pair';


--
-- Name: COLUMN pair_view.drugid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair_view.drugid IS 'The ID of the drug in the pair';


--
-- Name: COLUMN pair_view.drugname; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair_view.drugname IS 'The name of the drug in the pair';


--
-- Name: COLUMN pair_view.genesymbol; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair_view.genesymbol IS 'The symbol of the drug in the pair';


--
-- Name: COLUMN pair_view.guidelinename; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair_view.guidelinename IS 'The name for the guideline of this pair';


--
-- Name: COLUMN pair_view.guidelineurl; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair_view.guidelineurl IS 'The URL for the guideline of this pair';


--
-- Name: COLUMN pair_view.cpiclevel; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair_view.cpiclevel IS 'The CPIC-assigned level of the pair';


--
-- Name: COLUMN pair_view.clinpgxlevel; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair_view.clinpgxlevel IS 'The top level of ClinPGx Summary Annotation of the pair';


--
-- Name: COLUMN pair_view.pgxtesting; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair_view.pgxtesting IS 'The testing level of the label annotation from ClinPGx for this pair';


--
-- Name: COLUMN pair_view.pmids; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair_view.pmids IS 'The PMIDs for guideline publications of this pair';


--
-- Name: COLUMN pair_view.provisional; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair_view.provisional IS 'The CPIC level assigned to this pair is provisional, true if this pair is not part of a guideline';


--
-- Name: population; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.population (
    id integer DEFAULT nextval('cpic.cpic_id'::regclass) NOT NULL,
    publicationid integer,
    ethnicity text NOT NULL,
    population text,
    populationinfo text,
    subjecttype text,
    subjectcount integer DEFAULT 0,
    version integer DEFAULT 1
);


--
-- Name: TABLE population; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.population IS 'A population description of a group of subjects';


--
-- Name: COLUMN population.id; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.population.id IS 'A synthetic primary key ID';


--
-- Name: COLUMN population.publicationid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.population.publicationid IS 'A reference to a publication';


--
-- Name: COLUMN population.ethnicity; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.population.ethnicity IS 'The major ethnicity grouping of this population';


--
-- Name: COLUMN population.population; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.population.population IS 'The descriptive name of this population, optional';


--
-- Name: COLUMN population.populationinfo; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.population.populationinfo IS 'Further information about this population, optional';


--
-- Name: COLUMN population.subjecttype; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.population.subjecttype IS 'Information about the types of subjects in this population';


--
-- Name: COLUMN population.subjectcount; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.population.subjectcount IS 'The total number of subjects in this population';


--
-- Name: COLUMN population.version; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.population.version IS 'The version number, iterates on modification';


--
-- Name: population_frequency_view; Type: VIEW; Schema: cpic; Owner: -
--

CREATE VIEW cpic.population_frequency_view AS
 WITH x AS (
         SELECT a.id AS alleleid,
            a.genesymbol,
            a.name,
            f.key AS population_group,
                CASE
                    WHEN (jsonb_typeof(f.value) = 'null'::text) THEN NULL::numeric
                    ELSE (f.value)::numeric
                END AS freq_weighted_avg
           FROM (cpic.allele a
             CROSS JOIN LATERAL jsonb_each(a.frequency) f(key, value))
        ), y AS (
         SELECT f.alleleid,
            p.ethnicity,
            max(f.frequency) AS freq_max,
            min(f.frequency) AS freq_min,
            avg(f.frequency) AS freq_avg,
            sum(p.subjectcount) AS subjectcount
           FROM (cpic.population p
             JOIN cpic.allele_frequency f ON ((p.id = f.population)))
          GROUP BY f.alleleid, p.ethnicity
        )
 SELECT x.genesymbol,
    x.name,
    x.population_group,
    y.subjectcount,
    x.freq_weighted_avg,
    y.freq_avg,
    y.freq_max,
    y.freq_min
   FROM (x
     JOIN y ON (((x.alleleid = y.alleleid) AND (x.population_group = y.ethnicity))));


--
-- Name: VIEW population_frequency_view; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON VIEW cpic.population_frequency_view IS 'A summary of frequency data by allele and major population group';


--
-- Name: COLUMN population_frequency_view.genesymbol; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.population_frequency_view.genesymbol IS 'The HGNC symbol of the gene';


--
-- Name: COLUMN population_frequency_view.name; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.population_frequency_view.name IS 'The allele name';


--
-- Name: COLUMN population_frequency_view.population_group; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.population_frequency_view.population_group IS 'The major grouping of population';


--
-- Name: COLUMN population_frequency_view.subjectcount; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.population_frequency_view.subjectcount IS 'The count of subjects assigned the population group for the given allele';


--
-- Name: COLUMN population_frequency_view.freq_weighted_avg; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.population_frequency_view.freq_weighted_avg IS 'The average frequency weighted by total subjects';


--
-- Name: COLUMN population_frequency_view.freq_avg; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.population_frequency_view.freq_avg IS 'The unweighted average frequency (use with caution)';


--
-- Name: COLUMN population_frequency_view.freq_max; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.population_frequency_view.freq_max IS 'The maximum frequency observed';


--
-- Name: COLUMN population_frequency_view.freq_min; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.population_frequency_view.freq_min IS 'The minimum frequency observed';


--
-- Name: publication; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.publication (
    id integer DEFAULT nextval('cpic.cpic_id'::regclass) NOT NULL,
    guidelineid integer,
    title text,
    authors text[],
    journal text,
    month integer,
    page character varying(50),
    volume character varying(50),
    year integer,
    pmid text,
    pmcid text,
    doi text,
    url text,
    version integer DEFAULT 1,
    highlightedonsite boolean DEFAULT false,
    fulltextfile text
);


--
-- Name: TABLE publication; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.publication IS 'Documents published to an external resource';


--
-- Name: COLUMN publication.id; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.publication.id IS 'A synthetic numerical ID, auto-assigned, primary key';


--
-- Name: COLUMN publication.guidelineid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.publication.guidelineid IS 'The ID for the guideline this publication is about, optional';


--
-- Name: COLUMN publication.pmid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.publication.pmid IS 'The PubMed identifier for this publication';


--
-- Name: COLUMN publication.pmcid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.publication.pmcid IS 'The PubMed Central identifier for this publication';


--
-- Name: COLUMN publication.doi; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.publication.doi IS 'The Document Object Identifier (DOI) for this publication';


--
-- Name: COLUMN publication.url; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.publication.url IS 'The URL for this publication';


--
-- Name: COLUMN publication.highlightedonsite; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.publication.highlightedonsite IS 'true means this publication will show in the CPIC site Publications page, defaults to false';


--
-- Name: COLUMN publication.fulltextfile; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.publication.fulltextfile IS 'publicly-accessible URL to full text of publication';


--
-- Name: publication_supplement; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.publication_supplement (
    id integer DEFAULT nextval('cpic.cpic_id'::regclass) NOT NULL,
    publicationid integer NOT NULL,
    description text,
    url text NOT NULL,
    version integer DEFAULT 1
);


--
-- Name: TABLE publication_supplement; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.publication_supplement IS 'A table to hold optional supplemental files for publications';


--
-- Name: COLUMN publication_supplement.id; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.publication_supplement.id IS 'A synthetic numerical ID, primary key';


--
-- Name: COLUMN publication_supplement.publicationid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.publication_supplement.publicationid IS 'A foreign-key reference to the publication this is a supplement for';


--
-- Name: COLUMN publication_supplement.description; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.publication_supplement.description IS 'An optional free text description of the supplemental file';


--
-- Name: COLUMN publication_supplement.url; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.publication_supplement.url IS 'The publicly-accessible URL to the supplemental file';


--
-- Name: COLUMN publication_supplement.version; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.publication_supplement.version IS 'The version number, iterates on modification';


--
-- Name: recommendation_alleles_view; Type: VIEW; Schema: cpic; Owner: -
--

CREATE VIEW cpic.recommendation_alleles_view AS
 SELECT a.genesymbol,
    g.chr,
    g.lookupmethod,
    array_agg(DISTINCT a.name ORDER BY a.name) AS alleles,
    count(DISTINCT a.name) AS allele_count
   FROM (cpic.allele a
     JOIN cpic.gene g ON (((a.genesymbol)::text = (g.symbol)::text)))
  WHERE ((a.clinicalfunctionalstatus IS NOT NULL) AND (g.lookupmethod <> 'ALLELE_STATUS'::text))
  GROUP BY a.genesymbol, g.chr, g.lookupmethod
UNION
 SELECT g.symbol AS genesymbol,
    g.chr,
    g.lookupmethod,
    array_agg(DISTINCT a.value ORDER BY a.value) AS alleles,
    count(DISTINCT a.value) AS allele_count
   FROM (cpic.recommendation r
     JOIN cpic.drug d ON (((r.drugid)::text = (d.drugid)::text))),
    (LATERAL jsonb_each_text(r.lookupkey) a(key, value)
     JOIN cpic.gene g ON ((a.key = (g.symbol)::text)))
  WHERE ((r.allelestatus IS NOT NULL) AND (g.lookupmethod = 'ALLELE_STATUS'::text) AND (upper(a.value) !~~ '%NO%RESULT%'::text))
  GROUP BY g.symbol, g.chr, g.lookupmethod;


--
-- Name: VIEW recommendation_alleles_view; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON VIEW cpic.recommendation_alleles_view IS 'A list of genes that are used for recommendation lookup and the alleles to use for those lookups';


--
-- Name: sequence_location; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.sequence_location (
    id integer DEFAULT nextval('cpic.cpic_id'::regclass) NOT NULL,
    version integer DEFAULT 1,
    name text,
    chromosomelocation text,
    genelocation text,
    proteinlocation text,
    genesymbol character varying(50) NOT NULL,
    dbsnpid text,
    "position" integer,
    CONSTRAINT chromosomelocation_nn CHECK ((chromosomelocation IS NOT NULL)),
    CONSTRAINT position_nn CHECK (("position" IS NOT NULL))
);


--
-- Name: TABLE sequence_location; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.sequence_location IS 'A location on a sequence';


--
-- Name: COLUMN sequence_location.name; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.sequence_location.name IS 'The short name of this sequence location, arbitrary but often the gene location and nucleotide change';


--
-- Name: COLUMN sequence_location.chromosomelocation; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.sequence_location.chromosomelocation IS 'The partial HGVS representation of the location on the chromosomal sequence';


--
-- Name: COLUMN sequence_location.genelocation; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.sequence_location.genelocation IS 'The partial HGVS representation of the location on the gene sequence';


--
-- Name: COLUMN sequence_location.proteinlocation; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.sequence_location.proteinlocation IS 'The partial HGVS representation of the location on the protein sequence';


--
-- Name: COLUMN sequence_location.genesymbol; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.sequence_location.genesymbol IS 'The HGNC symbol fo the gene this squence location falls in';


--
-- Name: COLUMN sequence_location.dbsnpid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.sequence_location.dbsnpid IS 'The DBSNP identifier (rs#) for this location, optional';


--
-- Name: COLUMN sequence_location."position"; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.sequence_location."position" IS 'The position, or starting position, of this variation on the chromosomal/mitochondrial sequence';


--
-- Name: statistic; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.statistic (
    createdon timestamp without time zone NOT NULL,
    stattype text NOT NULL,
    statvalue numeric NOT NULL
);


--
-- Name: TABLE statistic; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.statistic IS 'A collection of numerical statistics with metadata about this database and other CPIC data';


--
-- Name: term; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.term (
    id integer DEFAULT nextval('cpic.cpic_id'::regclass) NOT NULL,
    category text NOT NULL,
    term text NOT NULL,
    functionaldef text,
    geneticdef text,
    loinc text,
    version integer DEFAULT 1
);


--
-- Name: TABLE term; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.term IS 'Standardized terms for clinical PGx test results';


--
-- Name: COLUMN term.id; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.term.id IS 'A synthetic numerical ID, auto-assigned, primary key';


--
-- Name: COLUMN term.category; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.term.category IS 'Category group this term falls into';


--
-- Name: COLUMN term.term; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.term.term IS 'The term name';


--
-- Name: COLUMN term.functionaldef; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.term.functionaldef IS 'The functional definition of the term';


--
-- Name: COLUMN term.geneticdef; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.term.geneticdef IS 'The genetic definition of the term';


--
-- Name: COLUMN term.loinc; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.term.loinc IS 'The LOINC identifier for the term';




--
-- Data for Name: allele_definition; Type: TABLE DATA; Schema: cpic; Owner: -
--

COPY cpic.allele_definition (id, version, genesymbol, name, pharmvarid, matchesreferencesequence, structuralvariation) FROM stdin;
9000	1	HLA-A	*31:01	\N	f	f
9001	1	HLA-B	*15:02	\N	f	f
9002	1	HLA-B	*57:01	\N	f	f
9003	1	HLA-B	*58:01	\N	f	f
6355217	15	CFTR	A349V	\N	f	f
6355227	15	CFTR	D192G	\N	f	f
6355231	15	CFTR	D924N	\N	f	f
777333	105	CFTR	E56K	\N	f	f
6355241	15	CFTR	E822K	\N	f	f
6355245	15	CFTR	F311del	\N	f	f
6355247	15	CFTR	F311L	\N	f	f
6355257	15	CFTR	G178E	\N	f	f
6355263	15	CFTR	G194R(G>C)	\N	f	f
6355265	15	CFTR	G314E	\N	f	f
6355271	15	CFTR	G576A	\N	f	f
6355273	15	CFTR	G970D	\N	f	f
6355279	15	CFTR	G1249R(G>A)	\N	f	f
6355281	15	CFTR	G1249R(G>C)	\N	f	f
6355285	15	CFTR	H939R	\N	f	f
6355287	15	CFTR	H1375P	\N	f	f
6355289	15	CFTR	I148T	\N	f	f
6355293	15	CFTR	I807M	\N	f	f
6355295	15	CFTR	I1027T	\N	f	f
6355303	15	CFTR	L320V	\N	f	f
6355305	15	CFTR	L967S	\N	f	f
6355307	15	CFTR	L997F(G>C)	\N	f	f
6355309	15	CFTR	L997F(G>T)	\N	f	f
6355311	15	CFTR	L1480P	\N	f	f
6355313	15	CFTR	M152V	\N	f	f
6355315	15	CFTR	M952I(G>A)	\N	f	f
6355319	15	CFTR	M952I(G>T)	\N	f	f
6355321	15	CFTR	M952T	\N	f	f
777357	105	CFTR	P67L	\N	f	f
6355325	15	CFTR	Q237E	\N	f	f
6355327	15	CFTR	Q237H	\N	f	f
6355331	15	CFTR	Q1291R	\N	f	f
6355335	15	CFTR	R75Q	\N	f	f
6355339	15	CFTR	R117G	\N	f	f
6355343	15	CFTR	R117L	\N	f	f
6355345	15	CFTR	R117P	\N	f	f
6355347	15	CFTR	R170H	\N	f	f
6355351	15	CFTR	R347L	\N	f	f
6355355	15	CFTR	R553Q	\N	f	f
6355357	15	CFTR	R668C	\N	f	f
6355359	15	CFTR	R792G	\N	f	f
6355361	15	CFTR	R933G	\N	f	f
777432	187	CYP2B6	*6	\N	f	f
777434	187	CYP2B6	*7	\N	f	f
777436	187	CYP2B6	*8	\N	f	f
777438	187	CYP2B6	*9	\N	f	f
777440	187	CYP2B6	*10	\N	f	f
777442	187	CYP2B6	*11	\N	f	f
777444	187	CYP2B6	*12	\N	f	f
777448	187	CYP2B6	*14	\N	f	f
777450	187	CYP2B6	*15	\N	f	f
777452	187	CYP2B6	*17	\N	f	f
777454	187	CYP2B6	*18	\N	f	f
777456	187	CYP2B6	*19	\N	f	f
777460	187	CYP2B6	*21	\N	f	f
777462	187	CYP2B6	*22	\N	f	f
777464	187	CYP2B6	*23	\N	f	f
777466	187	CYP2B6	*24	\N	f	f
777468	187	CYP2B6	*25	\N	f	f
777470	187	CYP2B6	*26	\N	f	f
777474	187	CYP2B6	*28	\N	f	f
777476	182	CYP2B6	*29	\N	f	t
777478	182	CYP2B6	*30	\N	f	t
777480	187	CYP2B6	*31	\N	f	f
777482	187	CYP2B6	*32	\N	f	f
777484	187	CYP2B6	*33	\N	f	f
777486	187	CYP2B6	*34	\N	f	f
777490	187	CYP2B6	*36	\N	f	f
777492	187	CYP2B6	*37	\N	f	f
777494	187	CYP2B6	*38	\N	f	f
2899154	101	CYP2B6	*45	\N	f	f
2899156	101	CYP2B6	*46	\N	f	f
2899158	101	CYP2B6	*47	\N	f	f
2899162	101	CYP2B6	*49	\N	f	f
5997308	34	CYP2B6	*50	\N	f	f
777532	187	CYP2C19	*1	\N	f	f
777578	187	CYP2C19	*26	\N	f	f
777580	187	CYP2C19	*28	\N	f	f
777592	187	CYP2C19	*34	\N	f	f
6235065	30	CYP2C19	*41	\N	f	f
7721584	8	CYP2C19	*42	\N	f	t
777678	187	CYP2C9	*6	\N	f	f
777680	187	CYP2C9	*7	\N	f	f
777690	187	CYP2C9	*12	\N	f	f
777704	187	CYP2C9	*19	\N	f	f
777716	187	CYP2C9	*25	\N	f	f
777732	187	CYP2C9	*33	\N	f	f
777746	187	CYP2C9	*40	\N	f	f
777766	187	CYP2C9	*50	\N	f	f
777776	187	CYP2C9	*55	\N	f	f
777794	187	CYP2C9	*64	\N	f	f
1406321	157	CYP2C9	*75	\N	f	f
1933003	137	CYP2C9	*85	\N	f	f
777958	187	CYP2D6	*12	\N	f	f
778094	187	CYP2D6	*88	\N	f	f
778112	187	CYP2D6	*97	\N	f	f
778178	187	CYP2D6	*130	\N	f	f
778180	187	CYP2D6	*131	\N	f	f
778182	187	CYP2D6	*132	\N	f	f
778184	187	CYP2D6	*133	\N	f	f
778188	187	CYP2D6	*135	\N	f	f
778192	187	CYP2D6	*137	\N	f	f
778196	187	CYP2D6	*139	\N	f	f
778200	187	CYP2D6	*141	\N	f	f
778202	187	CYP2D6	*142	\N	f	f
778206	187	CYP2D6	*144	\N	f	f
778208	187	CYP2D6	*145	\N	f	f
1103379	169	CYP2D6	*147	\N	f	f
1609527	150	CYP2D6	*148	\N	f	f
1103381	169	CYP2D6	*149	\N	f	f
2677013	109	CYP2D6	*151	\N	f	f
2091236	131	CYP2D6	*152	\N	f	f
2091238	131	CYP2D6	*153	\N	f	f
2091244	131	CYP2D6	*156	\N	f	f
2091246	131	CYP2D6	*157	\N	f	f
5763832	38	CYP2D6	*177	\N	f	f
5998158	34	CYP2D6	*178	\N	f	f
2784576	105	CYP4F2	*6	\N	f	f
7094208	10	MT-RNR1	m.930G>A	\N	f	f
779315	180	SLCO1B1	*20	\N	f	f
779343	180	SLCO1B1	*34	\N	f	f
779347	180	SLCO1B1	*36	\N	f	f
6970385	20	SLCO1B1	*55	\N	f	f
6970387	20	SLCO1B1	*56	\N	f	f
6970389	20	SLCO1B1	*57	\N	f	f
6970391	20	SLCO1B1	*58	\N	f	f
6355215	15	CFTR	A234D	\N	f	f
6355397	15	CFTR	V232D	\N	f	f
777552	187	CYP2C19	*11	\N	f	f
777576	187	CYP2C19	*25	\N	f	f
6235063	30	CYP2C19	*40	\N	f	f
777682	187	CYP2C9	*8	\N	f	f
777758	187	CYP2C9	*46	\N	f	f
6235320	30	CYP2C9	*86	\N	f	f
6235322	30	CYP2C9	*87	\N	f	f
6235324	30	CYP2C9	*88	\N	f	f
777946	187	CYP2D6	*6	\N	f	f
777948	187	CYP2D6	*7	\N	f	f
777950	187	CYP2D6	*8	\N	f	f
777952	187	CYP2D6	*9	\N	f	f
777970	187	CYP2D6	*19	\N	f	f
777978	187	CYP2D6	*23	\N	f	f
777988	187	CYP2D6	*28	\N	f	f
778014	187	CYP2D6	*41	\N	f	f
778016	187	CYP2D6	*42	\N	f	f
778018	187	CYP2D6	*43	\N	f	f
778020	187	CYP2D6	*44	\N	f	f
778022	187	CYP2D6	*45	\N	f	f
778024	187	CYP2D6	*46	\N	f	f
778026	187	CYP2D6	*47	\N	f	f
778028	187	CYP2D6	*48	\N	f	f
778030	187	CYP2D6	*49	\N	f	f
778032	187	CYP2D6	*50	\N	f	f
778034	187	CYP2D6	*51	\N	f	f
778036	187	CYP2D6	*52	\N	f	f
778038	187	CYP2D6	*53	\N	f	f
778040	187	CYP2D6	*54	\N	f	f
778042	187	CYP2D6	*55	\N	f	f
778044	187	CYP2D6	*56	\N	f	f
778048	187	CYP2D6	*58	\N	f	f
778050	187	CYP2D6	*59	\N	f	f
778052	187	CYP2D6	*60	\N	f	f
778054	182	CYP2D6	*61	\N	f	t
778056	187	CYP2D6	*62	\N	f	f
778058	182	CYP2D6	*63	\N	f	t
778060	187	CYP2D6	*64	\N	f	f
778062	187	CYP2D6	*65	\N	f	f
778064	182	CYP2D6	*68	\N	f	t
778066	187	CYP2D6	*69	\N	f	f
778068	187	CYP2D6	*70	\N	f	f
778070	187	CYP2D6	*71	\N	f	f
778072	187	CYP2D6	*72	\N	f	f
778074	187	CYP2D6	*73	\N	f	f
778076	187	CYP2D6	*74	\N	f	f
778078	187	CYP2D6	*75	\N	f	f
778080	187	CYP2D6	*81	\N	f	f
778082	187	CYP2D6	*82	\N	f	f
778084	187	CYP2D6	*83	\N	f	f
778086	187	CYP2D6	*84	\N	f	f
778088	187	CYP2D6	*85	\N	f	f
778090	187	CYP2D6	*86	\N	f	f
778092	187	CYP2D6	*87	\N	f	f
778096	187	CYP2D6	*89	\N	f	f
778108	187	CYP2D6	*95	\N	f	f
778114	187	CYP2D6	*98	\N	f	f
778186	187	CYP2D6	*134	\N	f	f
778204	187	CYP2D6	*143	\N	f	f
2677011	109	CYP2D6	*150	\N	f	f
2091250	131	CYP2D6	*159	\N	f	f
2091252	131	CYP2D6	*160	\N	f	f
2091254	131	CYP2D6	*161	\N	f	f
2091256	131	CYP2D6	*162	\N	f	f
2091258	131	CYP2D6	*163	\N	f	f
2677039	109	CYP2D6	*164	\N	f	f
2677043	109	CYP2D6	*166	\N	f	f
2677045	109	CYP2D6	*167	\N	f	f
2677047	109	CYP2D6	*168	\N	f	f
2677049	109	CYP2D6	*169	\N	f	f
2677051	109	CYP2D6	*170	\N	f	f
2677053	109	CYP2D6	*171	\N	f	f
3318539	86	CYP2D6	*172	\N	f	f
5175550	48	CYP2D6	*173	\N	f	f
5175552	48	CYP2D6	*174	\N	f	f
5175554	48	CYP2D6	*175	\N	f	f
5409119	44	CYP2D6	*176	\N	f	f
5998160	34	CYP2D6	*179	\N	f	f
5998162	34	CYP2D6	*180	\N	f	f
5998164	34	CYP2D6	*181	\N	f	f
5998166	34	CYP2D6	*182	\N	f	f
5998168	34	CYP2D6	*183	\N	f	f
5998170	34	CYP2D6	*184	\N	f	f
5998172	34	CYP2D6	*185	\N	f	f
778240	186	CYP4F2	*2	\N	f	f
778242	186	CYP4F2	*3	\N	f	f
2784572	105	CYP4F2	*4	\N	f	f
2784578	105	CYP4F2	*7	\N	f	f
3318585	86	CYP4F2	*8	\N	f	f
3318587	86	CYP4F2	*9	\N	f	f
3318593	86	CYP4F2	*12	\N	f	f
3318595	86	CYP4F2	*13	\N	f	f
3318599	86	CYP4F2	*15	\N	f	f
3318601	86	CYP4F2	*16	\N	f	t
4058604	63	CYP4F2	*17	\N	f	f
778337	105	DPYD	c.295_298delTCAT (*7)	\N	f	f
778780	107	G6PD	Taipei, Chinese-3	\N	f	f
778872	105	G6PD	West Virginia	\N	f	f
779080	186	NUDT15	*9	\N	f	f
3685882	44	RYR1	c.13913G>A	\N	f	f
3685898	44	RYR1	c.14168G>A	\N	f	f
3685900	44	RYR1	c.14186A>C	\N	f	f
3685902	44	RYR1	c.14197T>G	\N	f	f
3685910	44	RYR1	c.14270G>A	\N	f	f
779232	105	RYR1	c.14387A>G	\N	f	f
3685924	44	RYR1	c.14471T>C	\N	f	f
779234	105	RYR1	c.14477C>T	\N	f	f
779236	105	RYR1	c.14497C>T	\N	f	f
3685936	44	RYR1	c.14524G>A	\N	f	f
3685938	44	RYR1	c.14539G>C	\N	f	f
3685948	44	RYR1	c.14581C>T	\N	f	f
3685960	44	RYR1	c.14782A>G	\N	f	f
3685972	44	RYR1	c.14825G>T	\N	f	f
779283	180	SLCO1B1	*4	\N	f	f
779285	180	SLCO1B1	*5	\N	f	f
779297	180	SLCO1B1	*11	\N	f	f
779303	180	SLCO1B1	*14	\N	f	f
779305	180	SLCO1B1	*15	\N	f	f
779307	180	SLCO1B1	*16	\N	f	f
779321	180	SLCO1B1	*23	\N	f	f
779323	180	SLCO1B1	*24	\N	f	f
779325	180	SLCO1B1	*25	\N	f	f
779327	180	SLCO1B1	*26	\N	f	f
779331	180	SLCO1B1	*28	\N	f	f
779333	180	SLCO1B1	*29	\N	f	f
779335	180	SLCO1B1	*30	\N	f	f
779337	180	SLCO1B1	*31	\N	f	f
779339	180	SLCO1B1	*32	\N	f	f
1002693	171	SLCO1B1	*41	\N	f	f
1002695	171	SLCO1B1	*42	\N	f	f
1002697	171	SLCO1B1	*43	\N	f	f
1002701	171	SLCO1B1	*45	\N	f	f
1357091	159	SLCO1B1	*48	\N	f	t
6355395	15	CFTR	T1053I	\N	f	f
6355379	15	CFTR	S737F	\N	f	f
6355385	15	CFTR	S1159F	\N	f	f
6355393	15	CFTR	T338I	\N	f	f
6355399	15	CFTR	V562I	\N	f	f
6355401	15	CFTR	V754M	\N	f	f
6355403	15	CFTR	V1293G	\N	f	f
6355405	15	CFTR	W1282R	\N	f	f
6355407	15	CFTR	Y1014C	\N	f	f
6355409	15	CFTR	Y1032C	\N	f	f
777428	187	CYP2B6	*4	\N	f	f
777534	187	CYP2C19	*2	\N	f	f
777536	187	CYP2C19	*3	\N	f	f
777538	187	CYP2C19	*4	\N	f	f
777540	187	CYP2C19	*5	\N	f	f
777542	187	CYP2C19	*6	\N	f	f
777544	187	CYP2C19	*7	\N	f	f
777548	187	CYP2C19	*9	\N	f	f
777550	187	CYP2C19	*10	\N	f	f
777554	187	CYP2C19	*12	\N	f	f
777556	187	CYP2C19	*13	\N	f	f
777558	187	CYP2C19	*14	\N	f	f
777560	187	CYP2C19	*15	\N	f	f
777562	187	CYP2C19	*16	\N	f	f
777564	187	CYP2C19	*17	\N	f	f
777566	187	CYP2C19	*18	\N	f	f
777568	187	CYP2C19	*19	\N	f	f
777570	187	CYP2C19	*22	\N	f	f
777572	187	CYP2C19	*23	\N	f	f
777574	187	CYP2C19	*24	\N	f	f
777594	187	CYP2C19	*35	\N	f	f
777598	182	CYP2C19	*37	\N	f	t
777600	187	CYP2C19	*39	\N	f	f
777684	187	CYP2C9	*9	\N	f	f
777686	187	CYP2C9	*10	\N	f	f
777692	187	CYP2C9	*13	\N	f	f
777694	187	CYP2C9	*14	\N	f	f
777770	187	CYP2C9	*52	\N	f	f
777772	187	CYP2C9	*53	\N	f	f
777774	187	CYP2C9	*54	\N	f	f
777778	187	CYP2C9	*56	\N	f	f
777780	187	CYP2C9	*57	\N	f	f
777782	187	CYP2C9	*58	\N	f	f
777784	187	CYP2C9	*59	\N	f	f
777786	187	CYP2C9	*60	\N	f	f
777788	187	CYP2C9	*61	\N	f	f
777790	187	CYP2C9	*62	\N	f	f
777792	187	CYP2C9	*63	\N	f	f
777796	187	CYP2C9	*65	\N	f	f
777798	187	CYP2C9	*66	\N	f	f
777800	187	CYP2C9	*67	\N	f	f
777802	187	CYP2C9	*68	\N	f	f
777944	182	CYP2D6	*5	\N	f	t
777994	187	CYP2D6	*31	\N	f	f
778116	187	CYP2D6	*99	\N	f	f
778190	187	CYP2D6	*136	\N	f	f
1103377	169	CYP2D6	*146	\N	f	f
2091242	131	CYP2D6	*155	\N	f	f
6235905	30	CYP4F2	*18	\N	f	f
6235907	30	CYP4F2	*19	\N	f	f
6235909	30	CYP4F2	*20	\N	f	f
6235911	30	CYP4F2	*21	\N	f	f
6235913	30	CYP4F2	*22	\N	f	f
778435	105	DPYD	c.1905C>G	\N	f	f
778453	105	DPYD	c.2279C>T	\N	f	f
778483	105	DPYD	c.2977C>T	\N	f	f
778485	105	DPYD	c.2983G>T (*10)	\N	f	f
778714	105	G6PD	202G>A_376A>G_1264C>G	\N	f	f
778752	105	G6PD	A	\N	f	f
778712	105	G6PD	A- 202A_376G	\N	f	f
778742	105	G6PD	Acrokorinthos	\N	f	f
779002	105	G6PD	Andalus	\N	f	f
778826	105	G6PD	Asahikawa	\N	f	f
779038	105	G6PD	Brighton	\N	f	f
778774	105	G6PD	Gond	\N	f	f
778906	105	G6PD	Ierapetra	\N	f	f
778724	105	G6PD	Lagosanto	\N	f	f
778954	105	G6PD	Puerto Limon	\N	f	f
778990	105	G6PD	Santiago de Cuba, Morioka	\N	f	f
779041	105	IFNL3	rs12979860 reference (C)	\N	t	f
779043	105	IFNL3	rs12979860 variant (T)	\N	f	f
7096542	18	NAT2	*65	\N	f	f
7096544	18	NAT2	*66	\N	f	f
7096546	18	NAT2	*67	\N	f	f
7096548	18	NAT2	*68	\N	f	f
7096550	18	NAT2	*69	\N	f	f
3685874	44	RYR1	c.13673G>A	\N	f	f
3685876	44	RYR1	c.13672C>T	\N	f	f
3685878	44	RYR1	c.13702C>G	\N	f	f
3685880	44	RYR1	c.13760C>T	\N	f	f
3685886	44	RYR1	c.13934G>A	\N	f	f
3685888	44	RYR1	c.13990T>C	\N	f	f
3685890	44	RYR1	c.13994_13995delTCinsCT	\N	f	f
3685892	44	RYR1	c.14002C>T	\N	f	f
3685894	44	RYR1	c.14051T>C	\N	f	f
3685896	44	RYR1	c.14126C>T	\N	f	f
3685904	44	RYR1	c.14201G>A	\N	f	f
3685906	44	RYR1	c.14209C>T	\N	f	f
3685908	44	RYR1	c.14210G>A	\N	f	f
3685916	44	RYR1	c.14424C>A	\N	f	f
3685918	44	RYR1	c.14449A>T	\N	f	f
3685920	44	RYR1	c.14458G>A	\N	f	f
3685922	44	RYR1	c.14458G>T	\N	f	f
3685930	44	RYR1	c.14510delA	\N	f	f
3685932	44	RYR1	c.14509C>G	\N	f	f
779238	105	RYR1	c.14512C>G	\N	f	f
779240	105	RYR1	c.14545G>A	\N	f	f
3685942	44	RYR1	c.14558C>T	\N	f	f
3685944	44	RYR1	c.14567C>G	\N	f	f
779242	105	RYR1	c.14582G>A	\N	f	f
3685950	44	RYR1	c.14627A>G	\N	f	f
3685952	44	RYR1	c.14639T>C	\N	f	f
3685954	44	RYR1	c.14678G>A	\N	f	f
3685956	44	RYR1	c.14680G>A	\N	f	f
779244	105	RYR1	c.14693T>C	\N	f	f
3685962	44	RYR1	c.14803G>A	\N	f	f
3685964	44	RYR1	c.14813T>C	\N	f	f
3685966	44	RYR1	c.14814C>G	\N	f	f
3685968	44	RYR1	c.14817C>A	\N	f	f
3685970	44	RYR1	c.14818G>A	\N	f	f
3685974	44	RYR1	c.14879T>A	\N	f	f
3685976	44	RYR1	c.14918C>T	\N	f	f
3685978	44	RYR1	c.14968A>G	\N	f	f
3685980	44	RYR1	c.15059G>C	\N	f	f
1002623	171	SLCO1B1	*1	\N	t	f
779279	180	SLCO1B1	*2	\N	f	f
779287	180	SLCO1B1	*6	\N	f	f
779291	180	SLCO1B1	*8	\N	f	f
779293	180	SLCO1B1	*9	\N	f	f
1002685	171	SLCO1B1	*37	\N	f	f
1357093	159	SLCO1B1	*49	\N	f	t
7726082	5	TPMT	*45	\N	f	f
7726084	5	TPMT	*46	\N	f	f
7726086	5	TPMT	*47	\N	f	f
6355377	15	CFTR	S589N	\N	f	f
6355261	15	CFTR	G194R(G>A)	\N	f	f
6355291	15	CFTR	I175V	\N	f	f
6355317	15	CFTR	M952I(G>C)	\N	f	f
777379	105	CFTR	S549R(A>C)	\N	f	f
777430	187	CYP2B6	*5	\N	f	f
777446	187	CYP2B6	*13	\N	f	f
777472	187	CYP2B6	*27	\N	f	f
2899142	101	CYP2B6	*39	\N	f	f
2899146	101	CYP2B6	*41	\N	f	f
2899148	101	CYP2B6	*42	\N	f	f
2899150	101	CYP2B6	*43	\N	f	f
2899152	101	CYP2B6	*44	\N	f	f
777530	187	CYP2C19	*38	\N	t	f
777670	187	CYP2C9	*2	\N	f	f
777672	187	CYP2C9	*3	\N	f	f
777676	187	CYP2C9	*5	\N	f	f
777696	187	CYP2C9	*15	\N	f	f
777698	187	CYP2C9	*16	\N	f	f
777700	187	CYP2C9	*17	\N	f	f
777702	187	CYP2C9	*18	\N	f	f
777706	187	CYP2C9	*20	\N	f	f
777710	187	CYP2C9	*22	\N	f	f
777712	187	CYP2C9	*23	\N	f	f
777714	187	CYP2C9	*24	\N	f	f
777720	187	CYP2C9	*27	\N	f	f
777722	187	CYP2C9	*28	\N	f	f
777724	187	CYP2C9	*29	\N	f	f
777726	187	CYP2C9	*30	\N	f	f
777728	187	CYP2C9	*31	\N	f	f
777730	187	CYP2C9	*32	\N	f	f
777734	187	CYP2C9	*34	\N	f	f
777738	187	CYP2C9	*36	\N	f	f
777740	187	CYP2C9	*37	\N	f	f
777742	187	CYP2C9	*38	\N	f	f
777744	187	CYP2C9	*39	\N	f	f
777748	187	CYP2C9	*41	\N	f	f
777750	187	CYP2C9	*42	\N	f	f
777752	187	CYP2C9	*43	\N	f	f
777756	187	CYP2C9	*45	\N	f	f
777760	187	CYP2C9	*47	\N	f	f
777762	187	CYP2C9	*48	\N	f	f
777764	187	CYP2C9	*49	\N	f	f
777768	187	CYP2C9	*51	\N	f	f
777804	187	CYP2C9	*69	\N	f	f
777806	187	CYP2C9	*70	\N	f	f
1406315	157	CYP2C9	*72	\N	f	f
1406317	157	CYP2C9	*73	\N	f	f
1406319	157	CYP2C9	*74	\N	f	f
1932985	137	CYP2C9	*76	\N	f	f
1932987	137	CYP2C9	*77	\N	f	f
1932989	137	CYP2C9	*78	\N	f	f
1932991	137	CYP2C9	*79	\N	f	f
1932993	137	CYP2C9	*80	\N	f	f
1932997	137	CYP2C9	*82	\N	f	f
1932999	137	CYP2C9	*83	\N	f	f
1933001	137	CYP2C9	*84	\N	f	f
777936	187	CYP2D6	*1	\N	t	f
777938	187	CYP2D6	*2	\N	f	f
777940	187	CYP2D6	*3	\N	f	f
777942	187	CYP2D6	*4	\N	f	f
777954	187	CYP2D6	*10	\N	f	f
777956	187	CYP2D6	*11	\N	f	f
777962	187	CYP2D6	*14	\N	f	f
777964	187	CYP2D6	*15	\N	f	f
777966	187	CYP2D6	*17	\N	f	f
777968	187	CYP2D6	*18	\N	f	f
777972	187	CYP2D6	*20	\N	f	f
777974	187	CYP2D6	*21	\N	f	f
777976	187	CYP2D6	*22	\N	f	f
777980	187	CYP2D6	*24	\N	f	f
777982	187	CYP2D6	*25	\N	f	f
777984	187	CYP2D6	*26	\N	f	f
777986	187	CYP2D6	*27	\N	f	f
777990	187	CYP2D6	*29	\N	f	f
777992	187	CYP2D6	*30	\N	f	f
777996	187	CYP2D6	*32	\N	f	f
777998	187	CYP2D6	*33	\N	f	f
778000	187	CYP2D6	*34	\N	f	f
778002	187	CYP2D6	*35	\N	f	f
778004	187	CYP2D6	*36	\N	f	f
778006	187	CYP2D6	*37	\N	f	f
778008	187	CYP2D6	*38	\N	f	f
778010	187	CYP2D6	*39	\N	f	f
778012	187	CYP2D6	*40	\N	f	f
778098	187	CYP2D6	*90	\N	f	f
778118	187	CYP2D6	*100	\N	f	f
778120	187	CYP2D6	*101	\N	f	f
778122	187	CYP2D6	*102	\N	f	f
778124	187	CYP2D6	*103	\N	f	f
778126	187	CYP2D6	*104	\N	f	f
778128	187	CYP2D6	*105	\N	f	f
778130	187	CYP2D6	*106	\N	f	f
778132	187	CYP2D6	*107	\N	f	f
778136	187	CYP2D6	*109	\N	f	f
778138	187	CYP2D6	*110	\N	f	f
778140	187	CYP2D6	*111	\N	f	f
778142	187	CYP2D6	*112	\N	f	f
778144	187	CYP2D6	*113	\N	f	f
778164	187	CYP2D6	*123	\N	f	f
778170	187	CYP2D6	*126	\N	f	f
3318597	86	CYP4F2	*14	\N	f	f
6235915	30	CYP4F2	*23	\N	f	f
778800	106	G6PD	Mediterranean, Dallas, Panama, Sassari, Cagliari, Birmingham	\N	f	f
778802	105	G6PD	Pedoplis-Ckaro	\N	f	f
778744	105	G6PD	Santa Maria	\N	f	f
828095	104	MT-RNR1	Reference	\N	t	f
6481190	26	NAT2	*1	\N	t	f
6481192	26	NAT2	*4	\N	f	f
6481218	26	NAT2	*31	\N	f	f
6481220	26	NAT2	*32	\N	f	f
6481228	26	NAT2	*36	\N	f	f
6481230	26	NAT2	*37	\N	f	f
6481256	26	NAT2	*50	\N	f	f
6481262	26	NAT2	*53	\N	f	f
6481272	26	NAT2	*58	\N	f	f
7219570	16	NAT2	*70	\N	f	f
7219572	16	NAT2	*71	\N	f	f
7219574	16	NAT2	*72	\N	f	f
7219576	16	NAT2	*73	\N	f	f
7219578	16	NAT2	*74	\N	f	f
7219580	16	NAT2	*75	\N	f	f
3685694	44	RYR1	c.7771C>T	\N	f	f
3685726	44	RYR1	c.8518C>T	\N	f	f
3685758	44	RYR1	c.9758T>C	\N	f	f
3685790	44	RYR1	c.10891G>T	\N	f	f
3685822	44	RYR1	c.11953T>C	\N	f	f
3685856	44	RYR1	c.12553G>A	\N	f	f
1002689	171	SLCO1B1	*39	\N	f	f
6237969	30	SLCO1B1	*50	\N	f	f
6237971	30	SLCO1B1	*51	\N	f	f
6237973	30	SLCO1B1	*52	\N	f	f
6237975	30	SLCO1B1	*53	\N	f	f
6237977	30	SLCO1B1	*54	\N	f	f
777339	105	CFTR	F1074L	\N	f	f
777488	187	CYP2B6	*35	\N	f	f
777546	187	CYP2C19	*8	\N	f	f
777674	187	CYP2C9	*4	\N	f	f
777688	187	CYP2C9	*11	\N	f	f
778146	187	CYP2D6	*114	\N	f	f
778148	187	CYP2D6	*115	\N	f	f
778150	187	CYP2D6	*116	\N	f	f
778152	187	CYP2D6	*117	\N	f	f
778156	187	CYP2D6	*119	\N	f	f
778162	187	CYP2D6	*122	\N	f	f
778166	187	CYP2D6	*124	\N	f	f
778168	187	CYP2D6	*125	\N	f	f
778172	187	CYP2D6	*127	\N	f	f
778176	187	CYP2D6	*129	\N	f	f
778218	187	CYP3A5	*1	\N	t	f
778222	187	CYP3A5	*3	\N	f	f
778230	187	CYP3A5	*7	\N	f	f
778232	187	CYP3A5	*8	\N	f	f
778234	187	CYP3A5	*9	\N	f	f
2784574	105	CYP4F2	*5	\N	f	f
3827872	38	MT-RNR1	m.663A>G	\N	f	f
3827874	38	MT-RNR1	m.669T>C	\N	f	f
3827876	38	MT-RNR1	m.747A>G	\N	f	f
3827878	38	MT-RNR1	m.786G>A	\N	f	f
3827880	38	MT-RNR1	m.807A>C	\N	f	f
3827882	38	MT-RNR1	m.807A>G	\N	f	f
3827884	38	MT-RNR1	m.827A>G	\N	f	f
3827886	38	MT-RNR1	m.839A>G	\N	f	f
3827888	38	MT-RNR1	m.896A>G	\N	f	f
3827892	38	MT-RNR1	m.951G>A	\N	f	f
3827894	38	MT-RNR1	m.960C>del	\N	f	f
3827896	38	MT-RNR1	m.961T>G	\N	f	f
3827898	38	MT-RNR1	m.961T>del	\N	f	f
3827900	38	MT-RNR1	m.961T>del+Cn	\N	f	f
3827902	38	MT-RNR1	m.988G>A	\N	f	f
3827904	38	MT-RNR1	m.1095T>C	\N	f	f
3827906	38	MT-RNR1	m.1189T>C	\N	f	f
3827908	38	MT-RNR1	m.1243T>C	\N	f	f
3827910	38	MT-RNR1	m.1494C>T	\N	f	f
3827912	38	MT-RNR1	m.1520T>C	\N	f	f
3827914	38	MT-RNR1	m.1537C>T	\N	f	f
3827916	38	MT-RNR1	m.1555A>G	\N	f	f
3827918	38	MT-RNR1	m.1556C>T	\N	f	f
6481194	26	NAT2	*5	\N	f	f
6481196	26	NAT2	*6	\N	f	f
6481198	26	NAT2	*7	\N	f	f
6481200	26	NAT2	*10	\N	f	f
6481204	26	NAT2	*15	\N	f	f
6481206	26	NAT2	*16	\N	f	f
6481208	26	NAT2	*19	\N	f	f
6481210	26	NAT2	*21	\N	f	f
6481212	26	NAT2	*27	\N	f	f
6481216	26	NAT2	*30	\N	f	f
6481222	26	NAT2	*33	\N	f	f
6481226	26	NAT2	*35	\N	f	f
6481232	26	NAT2	*38	\N	f	f
6481236	26	NAT2	*40	\N	f	f
6481238	26	NAT2	*41	\N	f	f
6481240	26	NAT2	*42	\N	f	f
6481244	26	NAT2	*44	\N	f	f
6481246	26	NAT2	*45	\N	f	f
6481248	26	NAT2	*46	\N	f	f
6481250	26	NAT2	*47	\N	f	f
6481254	26	NAT2	*49	\N	f	f
6481258	26	NAT2	*51	\N	f	f
6481264	26	NAT2	*54	\N	f	f
6481266	26	NAT2	*55	\N	f	f
6481268	26	NAT2	*56	\N	f	f
6481274	26	NAT2	*59	\N	f	f
6481276	26	NAT2	*60	\N	f	f
6481280	26	NAT2	*62	\N	f	f
6481282	26	NAT2	*63	\N	f	f
6481284	26	NAT2	*64	\N	f	f
779064	186	NUDT15	*1	\N	t	f
779068	186	NUDT15	*3	\N	f	f
779070	186	NUDT15	*4	\N	f	f
779072	186	NUDT15	*5	\N	f	f
779074	186	NUDT15	*6	\N	f	f
779076	186	NUDT15	*7	\N	f	f
779078	186	NUDT15	*8	\N	f	f
779082	186	NUDT15	*10	\N	f	f
779084	186	NUDT15	*11	\N	f	f
779086	186	NUDT15	*12	\N	f	f
779088	186	NUDT15	*13	\N	f	f
779090	186	NUDT15	*14	\N	f	f
779092	186	NUDT15	*15	\N	f	f
779094	186	NUDT15	*16	\N	f	f
779096	186	NUDT15	*17	\N	f	f
779098	186	NUDT15	*18	\N	f	f
779100	186	NUDT15	*19	\N	f	f
779102	186	NUDT15	*20	\N	f	f
5881976	36	NUDT15	*21	\N	f	f
779313	180	SLCO1B1	*19	\N	f	f
779329	180	SLCO1B1	*27	\N	f	f
779341	180	SLCO1B1	*33	\N	f	f
1002691	171	SLCO1B1	*40	\N	f	f
1002699	171	SLCO1B1	*44	\N	f	f
1002705	171	SLCO1B1	*47	\N	f	f
779392	105	TPMT	*1	\N	t	f
779394	105	TPMT	*2	\N	f	f
779396	105	TPMT	*3A	\N	f	f
779398	105	TPMT	*3B	\N	f	f
779400	105	TPMT	*3C	\N	f	f
779402	105	TPMT	*4	\N	f	f
779404	105	TPMT	*5	\N	f	f
779406	105	TPMT	*6	\N	f	f
779408	105	TPMT	*7	\N	f	f
779410	105	TPMT	*8	\N	f	f
779412	105	TPMT	*9	\N	f	f
779414	105	TPMT	*10	\N	f	f
779416	105	TPMT	*11	\N	f	f
779418	105	TPMT	*12	\N	f	f
779420	105	TPMT	*13	\N	f	f
779422	105	TPMT	*14	\N	f	f
779424	105	TPMT	*15	\N	f	f
779426	105	TPMT	*16	\N	f	f
779428	105	TPMT	*17	\N	f	f
779430	105	TPMT	*18	\N	f	f
779432	105	TPMT	*19	\N	f	f
779434	105	TPMT	*20	\N	f	f
779436	105	TPMT	*21	\N	f	f
779438	105	TPMT	*22	\N	f	f
779440	105	TPMT	*23	\N	f	f
779442	105	TPMT	*24	\N	f	f
779444	105	TPMT	*25	\N	f	f
779446	105	TPMT	*26	\N	f	f
779448	105	TPMT	*27	\N	f	f
779450	105	TPMT	*28	\N	f	f
779452	105	TPMT	*29	\N	f	f
779454	105	TPMT	*30	\N	f	f
779456	105	TPMT	*31	\N	f	f
779458	105	TPMT	*32	\N	f	f
779460	105	TPMT	*33	\N	f	f
779462	105	TPMT	*34	\N	f	f
779464	105	TPMT	*35	\N	f	f
779466	105	TPMT	*36	\N	f	f
779468	105	TPMT	*37	\N	f	f
779470	105	TPMT	*38	\N	f	f
779472	105	TPMT	*39	\N	f	f
777458	187	CYP2B6	*20	\N	f	f
3318589	86	CYP4F2	*10	\N	f	f
3685332	44	RYR1	c.251C>T	\N	f	f
3685334	44	RYR1	c.418G>A	\N	f	f
3685336	44	RYR1	c.455C>A	\N	f	f
3685338	44	RYR1	c.463C>A	\N	f	f
3685340	44	RYR1	c.467G>A	\N	f	f
3685342	44	RYR1	c.479A>G	\N	f	f
779154	105	RYR1	c.487C>T	\N	f	f
779156	105	RYR1	c.488G>T	\N	f	f
3685348	44	RYR1	c.488G>A	\N	f	f
3685350	44	RYR1	c.493G>A	\N	f	f
3685352	44	RYR1	c.496G>A	\N	f	f
3685354	44	RYR1	c.497A>G	\N	f	f
3685356	44	RYR1	c.526G>A	\N	f	f
3685358	44	RYR1	c.528G>T	\N	f	f
3685362	44	RYR1	c.533A>G	\N	f	f
3685364	44	RYR1	c.533A>C	\N	f	f
3685368	44	RYR1	c.641C>T	\N	f	f
3685370	44	RYR1	c.652G>A	\N	f	f
3685372	44	RYR1	c.677T>A	\N	f	f
3685374	44	RYR1	c.680A>T	\N	f	f
779160	105	RYR1	c.742G>A	\N	f	f
779158	105	RYR1	c.742G>C	\N	f	f
3685380	44	RYR1	c.946C>T	\N	f	f
3685382	44	RYR1	c.947G>T	\N	f	f
779162	105	RYR1	c.982C>T	\N	f	f
779164	105	RYR1	c.1021G>A	\N	f	f
779166	105	RYR1	c.1021G>C	\N	f	f
3685392	44	RYR1	c.1024G>A	\N	f	f
3685394	44	RYR1	c.1100G>A	\N	f	f
3685396	44	RYR1	c.1100G>T	\N	f	f
3685398	44	RYR1	c.1144C>A	\N	f	f
779168	105	RYR1	c.1201C>T	\N	f	f
3685402	44	RYR1	c.1201C>A	\N	f	f
3685404	44	RYR1	c.1201C>G	\N	f	f
3685406	44	RYR1	c.1202G>T	\N	f	f
3685408	44	RYR1	c.1202G>A	\N	f	f
779170	105	RYR1	c.1209C>G	\N	f	f
3685412	44	RYR1	c.1411C>T	\N	f	f
3685416	44	RYR1	c.1453A>G	\N	f	f
3685418	44	RYR1	c.1459C>G	\N	f	f
3685420	44	RYR1	c.1460T>C	\N	f	f
3685422	44	RYR1	c.1475G>A	\N	f	f
3685424	44	RYR1	c.1553T>C	\N	f	f
779172	105	RYR1	c.1565A>C	\N	f	f
3685428	44	RYR1	c.1565A>G	\N	f	f
779174	105	RYR1	c.1589G>A	\N	f	f
779176	105	RYR1	c.1597C>T	\N	f	f
3685434	44	RYR1	c.1597C>A	\N	f	f
779178	105	RYR1	c.1598G>A	\N	f	f
3685438	44	RYR1	c.1615T>C	\N	f	f
3685440	44	RYR1	c.1615T>G	\N	f	f
3685442	44	RYR1	c.1630G>T	\N	f	f
3685446	44	RYR1	c.1834G>C	\N	f	f
779182	105	RYR1	c.1840C>T	\N	f	f
779184	105	RYR1	c.1841G>T	\N	f	f
3685452	44	RYR1	c.2050G>C	\N	f	f
3685454	44	RYR1	c.2122G>A	\N	f	f
3685456	44	RYR1	c.2447C>T	\N	f	f
3685458	44	RYR1	c.2537C>T	\N	f	f
3685460	44	RYR1	c.2654G>A	\N	f	f
3685462	44	RYR1	c.2797G>A	\N	f	f
3685464	44	RYR1	c.2924G>A	\N	f	f
3685466	44	RYR1	c.2996G>A	\N	f	f
3685468	44	RYR1	c.3095G>A	\N	f	f
3685470	44	RYR1	c.3127C>T	\N	f	f
3685472	44	RYR1	c.3166G>C	\N	f	f
3685476	44	RYR1	c.3172G>A	\N	f	f
3685478	44	RYR1	c.3224G>A	\N	f	f
3685480	44	RYR1	c.3418C>T	\N	f	f
3685482	44	RYR1	c.3527C>T	\N	f	f
3685484	44	RYR1	c.3656A>C	\N	f	f
3685486	44	RYR1	c.3667G>A	\N	f	f
3685488	44	RYR1	c.4024A>G	\N	f	f
3685490	44	RYR1	c.4178A>G	\N	f	f
3685492	44	RYR1	c.4400A>G	\N	f	f
3685494	44	RYR1	c.4711A>G	\N	f	f
3685496	44	RYR1	c.4747C>T	\N	f	f
3685498	44	RYR1	c.4763C>T	\N	f	f
3685500	44	RYR1	c.4775C>T	\N	f	f
3685502	44	RYR1	c.5024T>C	\N	f	f
3685506	44	RYR1	c.5036G>A	\N	f	f
3685508	44	RYR1	c.5132A>G	\N	f	f
3685510	44	RYR1	c.5183C>T	\N	f	f
3685512	44	RYR1	c.5186T>G	\N	f	f
3685514	44	RYR1	c.5317C>T	\N	f	f
3685516	44	RYR1	c.5341T>C	\N	f	f
3685518	44	RYR1	c.5360C>T	\N	f	f
3685520	44	RYR1	c.5440A>G	\N	f	f
3685522	44	RYR1	c.5441T>A	\N	f	f
3685524	44	RYR1	c.5890C>T	\N	f	f
3685526	44	RYR1	c.6037A>C	\N	f	f
3685528	44	RYR1	c.6178G>T	\N	f	f
3685530	44	RYR1	c.6302T>A	\N	f	f
3685532	44	RYR1	c.6304G>C	\N	f	f
3685536	44	RYR1	c.6377G>A	\N	f	f
3685538	44	RYR1	c.6387C>G	\N	f	f
3685540	44	RYR1	c.6388G>A	\N	f	f
3685542	44	RYR1	c.6478G>A	\N	f	f
779186	105	RYR1	c.6487C>T	\N	f	f
3685550	44	RYR1	c.6488G>T	\N	f	f
779190	105	RYR1	c.6502G>A	\N	f	f
3685580	44	RYR1	c.6743G>A	\N	f	f
779202	105	RYR1	c.7063C>T	\N	f	f
779206	105	RYR1	c.7282G>A	\N	f	f
3685646	44	RYR1	c.7292A>T	\N	f	f
779220	105	RYR1	c.7373G>A	\N	f	f
3685704	44	RYR1	c.7879G>C	\N	f	f
3685734	44	RYR1	c.8654C>G	\N	f	f
3685794	44	RYR1	c.11120G>T	\N	f	f
3685824	44	RYR1	c.11958C>G	\N	f	f
3685854	44	RYR1	c.12533G>T	\N	f	f
3685884	44	RYR1	c.13918A>G	\N	f	f
3685914	44	RYR1	c.14422_14423delinsAA	\N	f	f
779474	105	TPMT	*40	\N	f	f
779476	105	TPMT	*41	\N	f	f
779478	105	TPMT	*42	\N	f	f
779480	105	TPMT	*43	\N	f	f
779482	105	TPMT	*44	\N	f	f
779488	105	UGT1A1	*1	\N	t	f
779490	105	UGT1A1	*6	\N	f	f
779492	105	UGT1A1	*27	\N	f	f
779494	105	UGT1A1	*28	\N	f	f
779496	105	UGT1A1	*36	\N	f	f
779498	105	UGT1A1	*37	\N	f	f
779502	105	UGT1A1	*80+*28	\N	f	f
779504	105	UGT1A1	*80+*37	\N	f	f
779507	105	VKORC1	rs9923231 reference (C)	\N	t	f
779509	105	VKORC1	rs9923231 variant (T)	\N	f	f
778228	187	CYP3A5	*6	\N	f	f
777426	187	CYP2B6	*3	\N	f	f
2899144	101	CYP2B6	*40	\N	f	f
2899160	101	CYP2B6	*48	\N	f	f
777586	187	CYP2C19	*31	\N	f	f
777596	182	CYP2C19	*36	\N	f	t
777668	187	CYP2C9	*1	\N	t	f
777708	187	CYP2C9	*21	\N	f	f
777718	187	CYP2C9	*26	\N	f	f
777736	187	CYP2C9	*35	\N	f	f
777754	187	CYP2C9	*44	\N	f	f
777808	187	CYP2C9	*71	\N	f	f
1932995	137	CYP2C9	*81	\N	f	f
777960	182	CYP2D6	*13	\N	f	t
778104	187	CYP2D6	*93	\N	f	f
778134	187	CYP2D6	*108	\N	f	f
778154	187	CYP2D6	*118	\N	f	f
778158	187	CYP2D6	*120	\N	f	f
778194	187	CYP2D6	*138	\N	f	f
778198	187	CYP2D6	*140	\N	f	f
2091240	131	CYP2D6	*154	\N	f	f
2091248	131	CYP2D6	*158	\N	f	f
2677041	109	CYP2D6	*165	\N	f	f
778238	186	CYP4F2	*1	\N	t	f
3318591	86	CYP4F2	*11	\N	f	f
778327	105	DPYD	Reference	\N	t	f
778329	105	DPYD	c.46C>G	\N	f	f
778331	105	DPYD	c.61C>T	\N	f	f
778333	105	DPYD	c.62G>A	\N	f	f
778335	105	DPYD	c.85T>C (*9A)	\N	f	f
778339	105	DPYD	c.313G>A	\N	f	f
778341	105	DPYD	c.343A>G	\N	f	f
778343	105	DPYD	c.451A>G	\N	f	f
778345	105	DPYD	c.496A>G	\N	f	f
778347	105	DPYD	c.498G>A	\N	f	f
778349	105	DPYD	c.525G>A	\N	f	f
778351	105	DPYD	c.557A>G	\N	f	f
778353	105	DPYD	c.601A>C	\N	f	f
778355	105	DPYD	c.632A>G	\N	f	f
778357	105	DPYD	c.703C>T (*8)	\N	f	f
778359	105	DPYD	c.775A>G	\N	f	f
778361	105	DPYD	c.868A>G	\N	f	f
778363	105	DPYD	c.929T>C	\N	f	f
778365	105	DPYD	c.934C>T	\N	f	f
778367	105	DPYD	c.967G>A	\N	f	f
778369	105	DPYD	c.1003G>T (*11)	\N	f	f
778371	105	DPYD	c.1024G>A	\N	f	f
778373	105	DPYD	c.1057C>T	\N	f	f
778375	105	DPYD	c.1108A>G	\N	f	f
3942827	37	DPYD	c.1129-5923C>G	\N	f	f
778377	105	DPYD	c.1129-5923C>G, c.1236G>A (HapB3)	\N	f	f
778379	105	DPYD	c.1156G>T (*12)	\N	f	f
778381	105	DPYD	c.1180C>T	\N	f	f
778383	105	DPYD	c.1181G>T	\N	f	f
778385	105	DPYD	c.1218G>A	\N	f	f
778387	105	DPYD	c.1260T>A	\N	f	f
778389	105	DPYD	c.1278G>T	\N	f	f
778393	105	DPYD	c.1314T>G	\N	f	f
778395	105	DPYD	c.1349C>T	\N	f	f
778397	105	DPYD	c.1358C>G	\N	f	f
778399	105	DPYD	c.1371C>T	\N	f	f
778401	105	DPYD	c.1403C>A	\N	f	f
778403	105	DPYD	c.1475C>T	\N	f	f
778405	105	DPYD	c.1484A>G	\N	f	f
778407	105	DPYD	c.1519G>A	\N	f	f
778409	105	DPYD	c.1543G>A	\N	f	f
778411	105	DPYD	c.1577C>G	\N	f	f
778413	105	DPYD	c.1601G>A (*4)	\N	f	f
778415	105	DPYD	c.1615G>A	\N	f	f
778417	105	DPYD	c.1627A>G (*5)	\N	f	f
778419	105	DPYD	c.1679T>G (*13)	\N	f	f
778423	105	DPYD	c.1774C>T	\N	f	f
778425	105	DPYD	c.1775G>A	\N	f	f
778427	105	DPYD	c.1777G>A	\N	f	f
778429	105	DPYD	c.1796T>C	\N	f	f
778431	105	DPYD	c.1896T>C	\N	f	f
778433	105	DPYD	c.1898delC (*3)	\N	f	f
778437	105	DPYD	c.1905+1G>A (*2A)	\N	f	f
778445	105	DPYD	c.2161G>A	\N	f	f
778447	105	DPYD	c.2186C>T	\N	f	f
778449	105	DPYD	c.2194G>A (*6)	\N	f	f
778451	105	DPYD	c.2195T>G	\N	f	f
778455	105	DPYD	c.2303C>A	\N	f	f
778457	105	DPYD	c.2336C>A	\N	f	f
778459	105	DPYD	c.2482G>A	\N	f	f
778463	105	DPYD	c.2623A>C	\N	f	f
778465	105	DPYD	c.2639G>T	\N	f	f
778467	105	DPYD	c.2656C>T	\N	f	f
778469	105	DPYD	c.2657G>A (*9B)	\N	f	f
778471	105	DPYD	c.2846A>T	\N	f	f
778473	105	DPYD	c.2872A>G	\N	f	f
778475	105	DPYD	c.2915A>G	\N	f	f
778477	105	DPYD	c.2921A>T	\N	f	f
778479	105	DPYD	c.2933A>G	\N	f	f
778481	105	DPYD	c.2978T>G	\N	f	f
778487	105	DPYD	c.3049G>A	\N	f	f
778489	105	DPYD	c.3061G>C	\N	f	f
778491	105	DPYD	c.3067C>A	\N	f	f
779148	105	RYR1	Reference	\N	t	f
3685308	44	RYR1	c.38T>G	\N	f	f
3685312	44	RYR1	c.97A>G	\N	f	f
779150	105	RYR1	c.103T>C	\N	f	f
3685316	44	RYR1	c.119G>C	\N	f	f
779152	105	RYR1	c.130C>T	\N	f	f
3685320	44	RYR1	c.131G>A	\N	f	f
3685322	44	RYR1	c.152C>A	\N	f	f
3685324	44	RYR1	c.178G>A	\N	f	f
3685326	44	RYR1	c.178G>T	\N	f	f
3685328	44	RYR1	c.190T>C	\N	f	f
3685330	44	RYR1	c.212C>A	\N	f	f
3685366	44	RYR1	c.625G>A	\N	f	f
779188	105	RYR1	c.6488G>A	\N	f	f
3685548	44	RYR1	c.6488G>C	\N	f	f
3685556	44	RYR1	c.6548G>A	\N	f	f
3685558	44	RYR1	c.6599C>T	\N	f	f
3685560	44	RYR1	c.6612C>G	\N	f	f
779192	105	RYR1	c.6617C>G	\N	f	f
779194	105	RYR1	c.6617C>T	\N	f	f
3685566	44	RYR1	c.6628G>T	\N	f	f
3685568	44	RYR1	c.6635T>A	\N	f	f
3685570	44	RYR1	c.6640G>A	\N	f	f
3685572	44	RYR1	c.6671G>A	\N	f	f
3685574	44	RYR1	c.6670C>T	\N	f	f
3685576	44	RYR1	c.6710G>A	\N	f	f
3685578	44	RYR1	c.6742C>T	\N	f	f
3685582	44	RYR1	c.6757C>T	\N	f	f
3685584	44	RYR1	c.6838G>A	\N	f	f
3685588	44	RYR1	c.6961A>G	\N	f	f
779196	105	RYR1	c.7007G>A	\N	f	f
3685592	44	RYR1	c.7018T>C	\N	f	f
3685982	44	RYR1	c.15060G>C	\N	f	f
3685984	44	RYR1	c.14364+1G>T	\N	f	f
777424	187	CYP2B6	*2	\N	f	f
777307	105	CFTR	ivacaftor non-responsive CFTR sequence	\N	t	f
777315	105	CFTR	711+3A->G	\N	f	f
777309	105	CFTR	2789+5G->A	\N	f	f
777311	105	CFTR	3272-26A->G	\N	f	f
777313	105	CFTR	3849+10kbC->T	\N	f	f
777319	105	CFTR	A455E	\N	f	f
777317	105	CFTR	A1067T	\N	f	f
777321	105	CFTR	D110E	\N	f	f
777323	105	CFTR	D110H	\N	f	f
777329	105	CFTR	D579G	\N	f	f
777325	105	CFTR	D1152H	\N	f	f
777327	105	CFTR	D1270N	\N	f	f
777331	105	CFTR	E193K	\N	f	f
777335	105	CFTR	E831X	\N	f	f
777337	105	CFTR	F1052V	\N	f	f
777347	105	CFTR	G178R	\N	f	f
777349	105	CFTR	G551D	\N	f	f
777351	105	CFTR	G551S	\N	f	f
777341	105	CFTR	G1069R	\N	f	f
777343	105	CFTR	G1244E	\N	f	f
777345	105	CFTR	G1349D	\N	f	f
777353	105	CFTR	K1060T	\N	f	f
777355	105	CFTR	L206W	\N	f	f
777371	105	CFTR	R74W	\N	f	f
777363	105	CFTR	R117C	\N	f	f
777365	105	CFTR	R117H	\N	f	f
777367	105	CFTR	R347H	\N	f	f
777369	105	CFTR	R352Q	\N	f	f
777359	105	CFTR	R1070Q	\N	f	f
777361	105	CFTR	R1070W	\N	f	f
777381	105	CFTR	S549R(T>G)	\N	f	f
777383	105	CFTR	S945L	\N	f	f
777385	105	CFTR	S977F	\N	f	f
777373	105	CFTR	S1251N	\N	f	f
777375	105	CFTR	S1255P	\N	f	f
777582	187	CYP2C19	*29	\N	f	f
777584	187	CYP2C19	*30	\N	f	f
777588	187	CYP2C19	*32	\N	f	f
777590	187	CYP2C19	*33	\N	f	f
778100	187	CYP2D6	*91	\N	f	f
778102	187	CYP2D6	*92	\N	f	f
778106	187	CYP2D6	*94	\N	f	f
778110	187	CYP2D6	*96	\N	f	f
778160	187	CYP2D6	*121	\N	f	f
778174	187	CYP2D6	*128	\N	f	f
778439	105	DPYD	c.1906A>C	\N	f	f
778441	105	DPYD	c.1990G>T	\N	f	f
778443	105	DPYD	c.2021G>A	\N	f	f
778666	106	G6PD	B (reference)	\N	t	f
778748	105	G6PD	A- 680T_376G	\N	f	f
778750	105	G6PD	A- 968C_376G	\N	f	f
778916	105	G6PD	Aachen	\N	f	f
778962	105	G6PD	Abeno	\N	f	f
778950	105	G6PD	Alhambra	\N	f	f
778702	105	G6PD	Amazonia	\N	f	f
779006	105	G6PD	Amiens	\N	f	f
778700	105	G6PD	Amsterdam	\N	f	f
778956	105	G6PD	Anadia	\N	f	f
778746	105	G6PD	Ananindeua	\N	f	f
779036	105	G6PD	Arakawa	\N	f	f
778708	105	G6PD	Asahi	\N	f	f
778686	105	G6PD	Aures	\N	f	f
778858	105	G6PD	Bajo Maumere	\N	f	f
778844	105	G6PD	Bangkok	\N	f	f
779008	105	G6PD	Bangkok Noi	\N	f	f
778738	105	G6PD	Bao Loc	\N	f	f
778952	105	G6PD	Bari	\N	f	f
778766	105	G6PD	Belem	\N	f	f
779034	105	G6PD	Buenos Aires	\N	f	f
778762	105	G6PD	Cairo	\N	f	f
778922	105	G6PD	Calvo Mackenna	\N	f	f
779032	105	G6PD	Campinas	\N	f	f
778994	105	G6PD	Cassano	\N	f	f
778894	105	G6PD	Chatham	\N	f	f
778794	105	G6PD	Chikugo	\N	f	f
778854	105	G6PD	Chinese-1	\N	f	f
778900	105	G6PD	Chinese-5	\N	f	f
778816	105	G6PD	Cincinnati	\N	f	f
778840	105	G6PD	Cleveland Corum	\N	f	f
778674	105	G6PD	Gaohe	\N	f	f
778978	105	G6PD	Georgia	\N	f	f
778936	105	G6PD	Guadalajara	\N	f	f
778726	105	G6PD	Guangzhou	\N	f	f
778852	105	G6PD	Haikou	\N	f	f
778734	105	G6PD	Hammersmith	\N	f	f
778818	105	G6PD	Harilaou	\N	f	f
778998	105	G6PD	Harima	\N	f	f
778940	105	G6PD	Hartford	\N	f	f
778710	105	G6PD	Hechi	\N	f	f
778996	105	G6PD	Hermoupolis	\N	f	f
778676	105	G6PD	Honiara	\N	f	f
778770	105	G6PD	Ilesha	\N	f	f
778890	105	G6PD	Insuli	\N	f	f
778908	105	G6PD	Iwatsuki	\N	f	f
778970	105	G6PD	Japan, Shinagawa	\N	f	f
779022	105	G6PD	Kaiping, Anant, Dhon, Sapporo-like, Wosera	\N	f	f
778880	105	G6PD	Kalyan-Kerala, Jamnaga, Rohini	\N	f	f
778688	105	G6PD	Kambos	\N	f	f
779016	105	G6PD	Kamiube, Keelung	\N	f	f
778692	105	G6PD	Kamogawa	\N	f	f
778972	105	G6PD	Kawasaki	\N	f	f
778690	105	G6PD	Kozukata	\N	f	f
778944	105	G6PD	Krakow	\N	f	f
778848	105	G6PD	La Jolla	\N	f	f
778672	105	G6PD	Lages	\N	f	f
779026	105	G6PD	Laibin	\N	f	f
778842	105	G6PD	Lille	\N	f	f
778768	105	G6PD	Liuzhou	\N	f	f
778914	105	G6PD	Loma Linda	\N	f	f
778878	105	G6PD	Ludhiana	\N	f	f
778930	105	G6PD	Lynwood	\N	f	f
778932	105	G6PD	Madrid	\N	f	f
778776	105	G6PD	Mahidol	\N	f	f
778796	105	G6PD	Malaga	\N	f	f
778984	105	G6PD	Mediterranean Haplotype	\N	f	f
778696	105	G6PD	Metaponto	\N	f	f
778822	105	G6PD	Mexico City	\N	f	f
778790	105	G6PD	Miaoli	\N	f	f
778814	105	G6PD	Minnesota, Marion, Gastonia, LeJeune	\N	f	f
778902	105	G6PD	Mira d'Aire	\N	f	f
778860	105	G6PD	Mizushima	\N	f	f
778868	105	G6PD	Montalbano	\N	f	f
778920	105	G6PD	Montpellier	\N	f	f
778754	105	G6PD	Mt Sinai	\N	f	f
778974	105	G6PD	Munich	\N	f	f
6481202	26	NAT2	*14	\N	f	f
6481214	26	NAT2	*29	\N	f	f
6481224	26	NAT2	*34	\N	f	f
6481234	26	NAT2	*39	\N	f	f
6481242	26	NAT2	*43	\N	f	f
6481252	26	NAT2	*48	\N	f	f
6481260	26	NAT2	*52	\N	f	f
6481270	26	NAT2	*57	\N	f	f
6481278	26	NAT2	*61	\N	f	f
779295	180	SLCO1B1	*10	\N	f	f
777264	105	CACNA1S	c.520C>T	\N	f	f
779010	105	G6PD	Cosenza	\N	f	f
778698	105	G6PD	Costanzo	\N	f	f
778958	105	G6PD	Covao do Lobo	\N	f	f
778740	105	G6PD	Crispim	\N	f	f
778810	105	G6PD	Dagua	\N	f	f
778830	105	G6PD	Durham	\N	f	f
778888	105	G6PD	Farroupilha	\N	f	f
779018	105	G6PD	Flores	\N	f	f
779030	105	G6PD	Fukaya	\N	f	f
778896	105	G6PD	Fushan	\N	f	f
778680	105	G6PD	Gidra	\N	f	f
778718	105	G6PD	Murcia Oristano	\N	f	f
778704	105	G6PD	Musashino	\N	f	f
778716	105	G6PD	Namouru	\N	f	f
778788	105	G6PD	Nankang	\N	f	f
778828	105	G6PD	Nanning	\N	f	f
778784	105	G6PD	Naone	\N	f	f
778882	105	G6PD	Nara	\N	f	f
779024	105	G6PD	Neapolis	\N	f	f
779014	105	G6PD	Nice	\N	f	f
778808	105	G6PD	Nilgiri	\N	f	f
778668	105	G6PD	No name	\N	f	f
778824	105	G6PD	North Dallas	\N	f	f
778926	105	G6PD	Olomouc	\N	f	f
778876	105	G6PD	Omiya	\N	f	f
778684	105	G6PD	Orissa	\N	f	f
778866	105	G6PD	Osaka	\N	f	f
778694	105	G6PD	Palestrina	\N	f	f
778862	105	G6PD	Papua	\N	f	f
778904	105	G6PD	Partenope	\N	f	f
778986	105	G6PD	Pawnee	\N	f	f
778864	105	G6PD	Piotrkow	\N	f	f
778778	105	G6PD	Plymouth	\N	f	f
778942	105	G6PD	Praha	\N	f	f
778760	105	G6PD	Quing Yan	\N	f	f
778820	105	G6PD	Radlowo	\N	f	f
778886	105	G6PD	Rehevot	\N	f	f
778682	105	G6PD	Rignano	\N	f	f
778924	105	G6PD	Riley	\N	f	f
778838	105	G6PD	Roubaix	\N	f	f
778992	105	G6PD	S. Antioco	\N	f	f
778758	105	G6PD	Salerno Pyrgos	\N	f	f
778806	105	G6PD	Santiago	\N	f	f
778736	105	G6PD	Sao Borja	\N	f	f
778874	105	G6PD	Seoul	\N	f	f
778910	105	G6PD	Serres	\N	f	f
778772	105	G6PD	Shenzen	\N	f	f
778792	105	G6PD	Shinshu	\N	f	f
778812	105	G6PD	Sibari	\N	f	f
778730	105	G6PD	Sierra Leone	\N	f	f
778670	105	G6PD	Sinnai	\N	f	f
778706	105	G6PD	Songklanagarind	\N	f	f
779028	105	G6PD	Split	\N	f	f
778846	105	G6PD	Sugao	\N	f	f
778982	105	G6PD	Sumare	\N	f	f
778678	105	G6PD	Sunderland	\N	f	f
778980	105	G6PD	Surabaya	\N	f	f
778966	105	G6PD	Suwalki	\N	f	f
778720	105	G6PD	Swansea	\N	f	f
3564276	46	G6PD	Telti, Kobe	\N	f	f
778918	105	G6PD	Tenri	\N	f	f
778976	105	G6PD	Tokyo, Fukushima	\N	f	f
778782	105	G6PD	Toledo	\N	f	f
778928	105	G6PD	Tomah	\N	f	f
778912	105	G6PD	Tondela	\N	f	f
778898	105	G6PD	Torun	\N	f	f
778798	105	G6PD	Tsukui	\N	f	f
779000	105	G6PD	Union,Maewo, Chinese-2, Kalo	\N	f	f
778728	105	G6PD	Urayasu	\N	f	f
778964	105	G6PD	Utrecht	\N	f	f
778764	105	G6PD	Valladolid	\N	f	f
778732	105	G6PD	Vancouver	\N	f	f
778756	105	G6PD	Vanua Lava	\N	f	f
778870	105	G6PD	Viangchan, Jammu	\N	f	f
778892	105	G6PD	Villeurbanne	\N	f	f
778786	105	G6PD	Volendam	\N	f	f
778834	105	G6PD	Wayne	\N	f	f
778850	105	G6PD	Wexham	\N	f	f
3685618	44	RYR1	c.7084G>A	\N	f	f
3685620	44	RYR1	c.7085A>G	\N	f	f
3685624	44	RYR1	c.7090T>G	\N	f	f
3685626	44	RYR1	c.7097C>G	\N	f	f
3685628	44	RYR1	c.7099G>A	\N	f	f
3685630	44	RYR1	c.7112A>G	\N	f	f
3685632	44	RYR1	c.7123G>A	\N	f	f
779204	105	RYR1	c.7124G>C	\N	f	f
3685636	44	RYR1	c.7199A>G	\N	f	f
3685638	44	RYR1	c.7210G>A	\N	f	f
3685642	44	RYR1	c.7291G>A	\N	f	f
3685644	44	RYR1	c.7291G>T	\N	f	f
779208	105	RYR1	c.7300G>A	\N	f	f
779210	105	RYR1	c.7304G>A	\N	f	f
3685652	44	RYR1	c.7304G>T	\N	f	f
3685654	44	RYR1	c.7307G>A	\N	f	f
3685658	44	RYR1	c.7317G>C	\N	f	f
779212	105	RYR1	c.7354C>T	\N	f	f
3685662	44	RYR1	c.7355G>A	\N	f	f
3685664	44	RYR1	c.7355G>C	\N	f	f
3685666	44	RYR1	c.7358T>C	\N	f	f
779214	105	RYR1	c.7360C>T	\N	f	f
779216	105	RYR1	c.7361G>A	\N	f	f
779218	105	RYR1	c.7372C>T	\N	f	f
3685676	44	RYR1	c.7373G>T	\N	f	f
3685678	44	RYR1	c.7385C>T	\N	f	f
3685680	44	RYR1	c.7487C>T	\N	f	f
779222	105	RYR1	c.7522C>T	\N	f	f
779224	105	RYR1	c.7522C>G	\N	f	f
779226	105	RYR1	c.7523G>A	\N	f	f
3685690	44	RYR1	c.7760A>G	\N	f	f
3685692	44	RYR1	c.7771C>G	\N	f	f
3685696	44	RYR1	c.7777C>G	\N	f	f
3685698	44	RYR1	c.7778G>A	\N	f	f
3685700	44	RYR1	c.7787C>T	\N	f	f
3685702	44	RYR1	c.7816T>A	\N	f	f
3685706	44	RYR1	c.7879G>A	\N	f	f
3685708	44	RYR1	c.8005G>A	\N	f	f
3685710	44	RYR1	c.8026C>T	\N	f	f
3685712	44	RYR1	c.8054C>T	\N	f	f
3685714	44	RYR1	c.8188G>C	\N	f	f
3685716	44	RYR1	c.8189A>G	\N	f	f
3685718	44	RYR1	c.8198G>A	\N	f	f
3685720	44	RYR1	c.8290G>A	\N	f	f
3685724	44	RYR1	c.8360C>G	\N	f	f
3685728	44	RYR1	c.8527T>C	\N	f	f
3685730	44	RYR1	c.8600T>A	\N	f	f
3685732	44	RYR1	c.8638G>A	\N	f	f
3685736	44	RYR1	c.8729C>T	\N	f	f
3685738	44	RYR1	c.8926C>T	\N	f	f
3685740	44	RYR1	c.9152G>A	\N	f	f
3685742	44	RYR1	c.9268G>A	\N	f	f
778804	105	G6PD	Coimbra Shunde	\N	f	f
779020	105	G6PD	Yunan	\N	f	f
8102296	2	NUDT15	*22	\N	f	f
3685596	44	RYR1	c.7032G>C	\N	f	f
3685598	44	RYR1	c.7035C>A	\N	f	f
3685600	44	RYR1	c.7036G>A	\N	f	f
779198	105	RYR1	c.7042_7044delGAG	\N	f	f
3685604	44	RYR1	c.7043A>G	\N	f	f
779200	105	RYR1	c.7048G>A	\N	f	f
3685608	44	RYR1	c.7060G>A	\N	f	f
3685612	44	RYR1	c.7073T>A	\N	f	f
3685614	44	RYR1	c.7076G>A	\N	f	f
3685616	44	RYR1	c.7075C>T	\N	f	f
3685622	44	RYR1	c.7089C>G	\N	f	f
8103068	2	RYR1	c.9353C>T	\N	f	f
3685748	44	RYR1	c.9499C>T	\N	f	f
3685750	44	RYR1	c.9635A>G	\N	f	f
3685752	44	RYR1	c.9649T>C	\N	f	f
3685754	44	RYR1	c.9652G>A	\N	f	f
3685756	44	RYR1	c.9676G>C	\N	f	f
3685760	44	RYR1	c.9797T>C	\N	f	f
3685762	44	RYR1	c.9848G>A	\N	f	f
3685764	44	RYR1	c.9850T>A	\N	f	f
3685768	44	RYR1	c.10042C>T	\N	f	f
3685770	44	RYR1	c.10043G>A	\N	f	f
3685772	44	RYR1	c.10097G>A	\N	f	f
3685774	44	RYR1	c.10100A>G	\N	f	f
3685776	44	RYR1	c.10229C>A	\N	f	f
3685778	44	RYR1	c.10237A>T	\N	f	f
3685780	44	RYR1	c.10252A>G	\N	f	f
3685782	44	RYR1	c.10556C>T	\N	f	f
3685784	44	RYR1	c.10616G>A	\N	f	f
3685786	44	RYR1	c.10747G>C	\N	f	f
3685788	44	RYR1	c.10750G>C	\N	f	f
3685792	44	RYR1	c.11086G>C	\N	f	f
3685796	44	RYR1	c.11126C>T	\N	f	f
3685798	44	RYR1	c.11132C>T	\N	f	f
3685800	44	RYR1	c.11266C>G	\N	f	f
3685802	44	RYR1	c.11315G>A	\N	f	f
3685804	44	RYR1	c.11314C>T	\N	f	f
3685806	44	RYR1	c.11416G>A	\N	f	f
3685808	44	RYR1	c.11518G>A	\N	f	f
3685810	44	RYR1	c.11708G>A	\N	f	f
3685812	44	RYR1	c.11723A>T	\N	f	f
3685814	44	RYR1	c.11748T>G	\N	f	f
3685816	44	RYR1	c.11798A>G	\N	f	f
3685818	44	RYR1	c.11813G>A	\N	f	f
3685820	44	RYR1	c.11947C>T	\N	f	f
779230	105	RYR1	c.11969G>T	\N	f	f
3685828	44	RYR1	c.12028G>A	\N	f	f
3685830	44	RYR1	c.12064A>G	\N	f	f
3685832	44	RYR1	c.12115A>T	\N	f	f
3685834	44	RYR1	c.12121C>T	\N	f	f
3685836	44	RYR1	c.12149C>A	\N	f	f
3685838	44	RYR1	c.12242C>T	\N	f	f
3685840	44	RYR1	c.12310G>C	\N	f	f
3685842	44	RYR1	c.12355A>T	\N	f	f
3685844	44	RYR1	c.12383C>T	\N	f	f
3685846	44	RYR1	c.12398A>G	\N	f	f
3685848	44	RYR1	c.12406C>A	\N	f	f
3685850	44	RYR1	c.12413T>C	\N	f	f
3685852	44	RYR1	c.12532G>A	\N	f	f
3685858	44	RYR1	c.12689T>G	\N	f	f
3685860	44	RYR1	c.12700G>C	\N	f	f
3685862	44	RYR1	c.12700G>T	\N	f	f
3685864	44	RYR1	c.12848A>T	\N	f	f
3685866	44	RYR1	c.12881C>T	\N	f	f
3685868	44	RYR1	c.12884C>T	\N	f	f
8103194	2	RYR1	c.13502C>T	\N	f	f
3685872	44	RYR1	c.13513G>C	\N	f	f
779500	105	UGT1A1	*80	\N	f	f
1508724	86	ABCG2	rs2231142 reference (G)	\N	t	f
1508726	86	ABCG2	rs2231142 variant (T)	\N	f	f
777262	105	CACNA1S	Reference	\N	t	f
777266	105	CACNA1S	c.3257G>A	\N	f	f
6355213	15	CFTR	A120T	\N	f	f
6355249	15	CFTR	F508C	\N	f	f
6606011	13	CFTR	F508C,S1251N	\N	f	f
6355297	15	CFTR	I1139V	\N	f	f
6355329	15	CFTR	Q359R	\N	f	f
6355367	15	CFTR	R1162L	\N	f	f
6355369	15	CFTR	R1283M	\N	f	f
777377	105	CFTR	S549N	\N	f	f
6355387	15	CFTR	S1159P	\N	f	f
777422	187	CYP2B6	*1	\N	t	f
8101105	2	CYP2D6	*186	\N	f	f
8101126	2	CYP3A5	*10	\N	f	f
8101128	2	CYP3A5	*11	\N	f	f
778391	105	DPYD	c.1294G>A	\N	f	f
778421	105	DPYD	c.1682G>T	\N	f	f
778461	105	DPYD	c.2582A>G	\N	f	f
778836	105	G6PD	Aveiro	\N	f	f
778938	105	G6PD	Beverly Hills, Genova, Iwate, Niigata, Yamaguchi	\N	f	f
779012	105	G6PD	Canton, Taiwan-Hakka, Gifu-like, Agrigento-like	\N	f	f
778960	105	G6PD	Clinic	\N	f	f
779004	105	G6PD	Figuera da Foz	\N	f	f
778934	105	G6PD	Iowa, Walter Reed, Springfield	\N	f	f
778884	105	G6PD	Manhattan	\N	f	f
778948	105	G6PD	Nashville, Anaheim, Portici	\N	f	f
778968	105	G6PD	Riverside	\N	f	f
778856	105	G6PD	Seattle, Lodi, Modena, Ferrara II, Athens-like	\N	f	f
778832	105	G6PD	Stonybrook	\N	f	f
778722	105	G6PD	Ube Konan	\N	f	f
778946	105	G6PD	Wisconsin	\N	f	f
8102298	2	NUDT15	*23	\N	f	f
3685310	44	RYR1	c.51_53del	\N	f	f
3685360	44	RYR1	c.529C>T	\N	f	f
3685386	44	RYR1	c.992_994dup	\N	f	f
8102726	2	RYR1	c.1390C>A	\N	f	f
3685414	44	RYR1	c.1422G>T	\N	f	f
779180	105	RYR1	c.1654C>T	\N	f	f
3685474	44	RYR1	c.3166G>A	\N	f	f
8102806	2	RYR1	c.4055C>G	\N	f	f
8102820	2	RYR1	c.4999C>T	\N	f	f
3685504	44	RYR1	c.5033A>G	\N	f	f
3685534	44	RYR1	c.6349G>C	\N	f	f
3685554	44	RYR1	c.6544A>T	\N	f	f
3685586	44	RYR1	c.6847A>C	\N	f	f
3685594	44	RYR1	c.7025A>G	\N	f	f
8231269	1	RYR1	c.7123G>C	\N	f	f
3685688	44	RYR1	c.7528T>C	\N	f	f
8103010	2	RYR1	c.7625G>A	\N	f	f
3685722	44	RYR1	c.8327C>T	\N	f	f
779228	105	RYR1	c.9310G>A	\N	f	f
3685746	44	RYR1	c.9356G>A	\N	f	f
3685766	44	RYR1	c.9868G>A	\N	f	f
3685870	44	RYR1	c.13505A>G	\N	f	f
3685656	44	RYR1	c.7310C>T	\N	f	f
8232369	1	CYP2D6	*68+*4	\N	f	f
8232371	1	CYP2D6	*36+*10	\N	f	f
8232373	1	CYP2D6	*13+*1	\N	f	f
8232376	1	CYP2D6	*13+*2	\N	f	f
8232378	1	CYP2D6	*13+*68x2+*4	\N	f	f
8232380	1	CYP2D6	*36x2+*10	\N	f	f
8232383	1	CYP2D6	*68+*2	\N	f	f
\.


--
-- Data for Name: allele_frequency; Type: TABLE DATA; Schema: cpic; Owner: -
--

COPY cpic.allele_frequency (alleleid, population, frequency, label, version) FROM stdin;
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777963	8347310	\N	\N	1
777965	8347310	\N	\N	1
777967	8347310	\N	\N	1
779712	8347310	0.0068	0.0068	1
777969	8347310	\N	\N	1
777971	8347310	\N	\N	1
777973	8347310	\N	\N	1
777975	8347310	\N	\N	1
777977	8347310	\N	\N	1
777979	8347310	\N	\N	1
777981	8347310	\N	\N	1
777983	8347310	\N	\N	1
777985	8347310	\N	\N	1
777987	8347310	\N	\N	1
777989	8347310	\N	\N	1
777991	8347310	\N	\N	1
779725	8347310	0.0068	0.0068	1
777993	8347310	\N	\N	1
777995	8347310	\N	\N	1
777997	8347310	\N	\N	1
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778001	8347310	\N	\N	1
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779732	8347310	0	0.0	1
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779734	8347310	\N	\N	1
778007	8347310	\N	\N	1
778009	8347310	\N	\N	1
778011	8347310	\N	\N	1
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779740	8347310	0	0.0	1
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778017	8347310	\N	\N	1
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779744	8347310	\N	\N	1
778021	8347310	\N	\N	1
778023	8347310	\N	\N	1
779747	8347310	0	0.0	1
778025	8347310	\N	\N	1
778027	8347310	\N	\N	1
778029	8347310	\N	\N	1
778031	8347310	\N	\N	1
778033	8347310	\N	\N	1
778035	8347310	\N	\N	1
778037	8347310	\N	\N	1
778039	8347310	\N	\N	1
778041	8347310	\N	\N	1
778043	8347310	\N	\N	1
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778051	8347310	\N	\N	1
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778071	8347310	\N	\N	1
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778081	8347310	\N	\N	1
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778085	8347310	\N	\N	1
778087	8347310	\N	\N	1
778089	8347310	\N	\N	1
778091	8347310	\N	\N	1
778093	8347310	\N	\N	1
778095	8347310	\N	\N	1
778097	8347310	\N	\N	1
778099	8347310	\N	\N	1
778101	8347310	\N	\N	1
778103	8347310	\N	\N	1
778105	8347310	\N	\N	1
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778117	8347310	\N	\N	1
778119	8347310	\N	\N	1
778121	8347310	\N	\N	1
778123	8347310	\N	\N	1
778125	8347310	\N	\N	1
778127	8347310	\N	\N	1
778129	8347310	\N	\N	1
778131	8347310	\N	\N	1
778133	8347310	\N	\N	1
778135	8347310	\N	\N	1
778137	8347310	\N	\N	1
778139	8347310	\N	\N	1
778141	8347310	\N	\N	1
778143	8347310	\N	\N	1
778145	8347310	\N	\N	1
778147	8347310	\N	\N	1
778149	8347310	\N	\N	1
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778157	8347310	\N	\N	1
778159	8347310	\N	\N	1
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778185	8347310	\N	\N	1
778187	8347310	\N	\N	1
778189	8347310	\N	\N	1
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778193	8347310	\N	\N	1
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778201	8347310	\N	\N	1
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778209	8347310	\N	\N	1
1103378	8347310	\N	\N	1
2955640	8347310	\N	\N	1
1103380	8347310	\N	\N	1
1609528	8347310	\N	\N	1
1103382	8347310	\N	\N	1
2091237	8347310	\N	\N	1
2091239	8347310	\N	\N	1
2091241	8347310	\N	\N	1
2091243	8347310	\N	\N	1
2091245	8347310	\N	\N	1
2091247	8347310	\N	\N	1
2091249	8347310	\N	\N	1
2091251	8347310	\N	\N	1
2091253	8347310	\N	\N	1
2091255	8347310	\N	\N	1
2091257	8347310	\N	\N	1
2091259	8347310	\N	\N	1
779688	8347311	0.0037	0.0037	1
1777304	8347311	\N	\N	1
777939	8347311	0.1398	0.1398	1
779691	8347311	0.0184	0.0184	1
1777307	8347311	\N	\N	1
777941	8347311	0.0018	0.0018	1
779694	8347311	\N	\N	1
777943	8347311	0.0386	0.0386	1
1777311	8347311	0.0276	0.0276	1
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777945	8347311	0.0643	0.0643	1
777947	8347311	0.0055	0.0055	1
779699	8347311	\N	\N	1
777949	8347311	0	0.0	1
777951	8347311	0	0.0	1
777953	8347311	0.0018	0.0018	1
779703	8347311	\N	\N	1
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779705	8347311	0.0018	0.0018	1
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777961	8347311	0	0.0	1
777963	8347311	\N	\N	1
777965	8347311	\N	\N	1
777967	8347311	0.1912	0.1912	1
779712	8347311	0	0.0	1
777969	8347311	\N	\N	1
777971	8347311	\N	\N	1
777973	8347311	\N	\N	1
777975	8347311	\N	\N	1
777977	8347311	\N	\N	1
777979	8347311	\N	\N	1
777981	8347311	\N	\N	1
777983	8347311	\N	\N	1
777985	8347311	\N	\N	1
777987	8347311	\N	\N	1
777989	8347311	\N	\N	1
777991	8347311	0.0754	0.0754	1
779725	8347311	\N	\N	1
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779732	8347311	\N	\N	1
778005	8347311	0.0055	0.0055	1
779734	8347311	\N	\N	1
778007	8347311	\N	\N	1
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779740	8347311	0	0.0	1
779741	8347311	\N	\N	1
778017	8347311	0.0055	0.0055	1
778019	8347311	0.0037	0.0037	1
779744	8347311	\N	\N	1
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778023	8347311	\N	\N	1
779747	8347311	0.0018	0.0018	1
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778039	8347311	\N	\N	1
778041	8347311	\N	\N	1
778043	8347311	\N	\N	1
778045	8347311	0.0018	0.0018	1
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778053	8347311	\N	\N	1
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1103378	8347311	\N	\N	1
2955640	8347311	\N	\N	1
1103380	8347311	\N	\N	1
1609528	8347311	\N	\N	1
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2091237	8347311	\N	\N	1
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2091255	8347311	\N	\N	1
2091257	8347311	\N	\N	1
2091259	8347311	\N	\N	1
779688	8347312	0.008	0.008	1
1777304	8347312	\N	\N	1
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777939	8347312	0.06	0.06	1
779691	8347312	0.012	0.012	1
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777943	8347312	0.055	0.055	1
1777311	8347312	0.024	0.024	1
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777945	8347312	0.028	0.028	1
777947	8347312	0.002	0.002	1
779699	8347312	\N	\N	1
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777953	8347312	0.004	0.004	1
779703	8347312	\N	\N	1
777955	8347312	0.038	0.038	1
779705	8347312	\N	\N	1
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779712	8347312	0.002	0.002	1
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777985	8347312	\N	\N	1
777987	8347312	\N	\N	1
777989	8347312	\N	\N	1
777991	8347312	0.077	0.077	1
779725	8347312	0.002	0.002	1
777993	8347312	\N	\N	1
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778001	8347312	\N	\N	1
778003	8347312	0.009	0.009	1
779732	8347312	\N	\N	1
778005	8347312	0.006	0.006	1
779734	8347312	\N	\N	1
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778013	8347312	0.003	0.003	1
778015	8347312	0.149	0.149	1
779740	8347312	\N	\N	1
779741	8347312	\N	\N	1
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778035	8347312	\N	\N	1
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778039	8347312	\N	\N	1
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778061	8347312	\N	\N	1
778063	8347312	\N	\N	1
778065	8347312	\N	\N	1
778067	8347312	\N	\N	1
778069	8347312	\N	\N	1
778071	8347312	\N	\N	1
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778097	8347312	\N	\N	1
778099	8347312	\N	\N	1
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778119	8347312	\N	\N	1
778121	8347312	\N	\N	1
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778141	8347312	\N	\N	1
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778153	8347312	\N	\N	1
778155	8347312	\N	\N	1
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778161	8347312	\N	\N	1
778163	8347312	\N	\N	1
778165	8347312	\N	\N	1
778167	8347312	\N	\N	1
778169	8347312	\N	\N	1
778171	8347312	\N	\N	1
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778175	8347312	\N	\N	1
778177	8347312	\N	\N	1
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