Methods

Table includes variants based on an update of the CPIC guideline for potent volatile anesthetic agents and succinylcholine. The guideline update includes RYR1 variants that were evaluated by the ClinGen malignant hyperthermia susceptibility (MHS) variant curation expert panel and classified for RYR1-related malignant hyperthermia susceptibility.

gnomAD v4 was queried with the variant positions or rsIDs.
gnomAD population description - PharmGKB biogeographical group mapping:
African/African American - Sub-Saharan African
South Asian - Central/South Asian
Latino/Admixed American - Latino
East Asian - East Asian
Non-Finnish European - European
Ashkenazi Jewish - Near Eastern

Caveats to estimated allele, frequencies:
Biogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details, including the definitions of each group, can be found at https://www.pharmgkb.org/page/biogeographicalGroups. We strongly recommend that users use either the publication or the PharmGKB link provided to familiarize themselves with the grouping system before using these allele frequencies. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.