--
--

\restrict Y0YrVHByT0fsOLTKW7ZkU2EomNLMQt3W26vOMBPP7JYNenedMg5Q42XYmDEsIf2


SET transaction_timeout = 0;
SELECT pg_catalog.set_config('search_path', '', false);

--
-- Name: cpic; Type: SCHEMA; Schema: -; Owner: -
--

CREATE SCHEMA cpic;


--
-- Name: increment_version(); Type: FUNCTION; Schema: cpic; Owner: -
--

CREATE FUNCTION cpic.increment_version() RETURNS trigger
    LANGUAGE plpgsql
    AS $$
BEGIN
  new.version := new.version + 1;
  return new;
END;
$$;


--
-- Name: pharmgkb_guideline_alleles(text); Type: FUNCTION; Schema: cpic; Owner: -
--

CREATE FUNCTION cpic.pharmgkb_guideline_alleles(pharmgkbdrugid text) RETURNS TABLE(genesymbol text, chr text, lookupmethod text, alleles text[])
    LANGUAGE sql STABLE
    AS $$
select
    a.genesymbol,
    g.chr,
    g.lookupmethod,
    array_agg(distinct a.name order by a.name) as alleles
from allele a join gene g on a.genesymbol=g.symbol
where
    a.clinicalfunctionalstatus is not null
    and g.lookupmethod!='ALLELE_STATUS'
    and a.genesymbol in (
        select distinct jsonb_object_keys(p.lookupkey) as genes
        from recommendation p join guideline g on p.guidelineid = g.id join drug d on p.drugid=d.drugid
        where d.pharmgkbid=pharmgkbdrugid
    )
group by a.genesymbol, g.chr, g.lookupmethod
union all
select
    g.symbol as genesymbol,
    g.chr,
    g.lookupmethod,
    array_agg(distinct a.value order by a.value) as alleles
from
    recommendation r
    join drug d on r.drugid = d.drugid,
    jsonb_each_text(r.lookupkey) a
    join gene g on (a.key=g.symbol)
where
    r.allelestatus is not null
    and g.lookupmethod='ALLELE_STATUS'
    and d.pharmgkbid=pharmgkbdrugid
    and upper(a.value) != 'NO RESULT'
group by g.symbol, g.chr, g.lookupmethod
$$;


--
-- Name: FUNCTION pharmgkb_guideline_alleles(pharmgkbdrugid text); Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON FUNCTION cpic.pharmgkb_guideline_alleles(pharmgkbdrugid text) IS 'For a given PharmGKB drug ID, list the alleles that are options for looking up recommendations';


--
-- Name: pharmgkb_guideline_recommendation(text, text); Type: FUNCTION; Schema: cpic; Owner: -
--

CREATE FUNCTION cpic.pharmgkb_guideline_recommendation(drugidarg text, lookupkeyarg text) RETURNS TABLE(drugname text, recommendationid integer, implications jsonb, drugrecommendation text, classification text, phenotypes jsonb, activityscore jsonb, allelestatus jsonb, population text, comments text)
    LANGUAGE sql STABLE
    AS $$
select
    d.name as drugname,
    r.id as recommendationid,
    r.implications,
    r.drugrecommendation,
    r.classification,
    r.phenotypes,
    r.activityscore,
    r.allelestatus,
    r.population,
    r.comments
from recommendation r join drug d on r.drugid = d.drugid join guideline g on r.guidelineid = g.id
where lookupkey <@ (
    select jsonb_object_agg(a.key, coalesce(d.lookupkey -> a.key, a.value)) as lookup
    from
        json_each(lookupkeyArg::json) a
            left join diplotype d on (d.diplotypekey=jsonb_build_object(a.key, a.value))
)
  and d.pharmgkbid=drugidArg
$$;


--
-- Name: FUNCTION pharmgkb_guideline_recommendation(drugidarg text, lookupkeyarg text); Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON FUNCTION cpic.pharmgkb_guideline_recommendation(drugidarg text, lookupkeyarg text) IS 'For a given PharmGKB guideline and genotype lookup JSON key, give the matching recommendations';


--
-- Name: pharmgkb_recommendation(text); Type: FUNCTION; Schema: cpic; Owner: -
--

CREATE FUNCTION cpic.pharmgkb_recommendation(lookupkeyarg text) RETURNS TABLE(drugname text, drugid text, recommendationid integer, implications jsonb, drugrecommendation text, classification text, phenotypes jsonb, activityscore jsonb, allelestatus jsonb, population text, comments text, guidelineurl text)
    LANGUAGE sql STABLE
    AS $$
select
    d.name as drugname,
    d.pharmgkbid as drugid,
    r.id as recommendationid,
    r.implications,
    r.drugrecommendation,
    r.classification,
    r.phenotypes,
    r.activityscore,
    r.allelestatus,
    r.population,
    r.comments,
    g.url as guidelineurl
from recommendation r join drug d on r.drugid = d.drugid join guideline g on r.guidelineid = g.id
where lookupkey <@ (
    select jsonb_object_agg(a.key, coalesce(d.lookupkey -> a.key, a.value)) as lookup
    from
        json_each(lookupKeyArg::json) a
            left join diplotype d on (d.diplotypekey=jsonb_build_object(a.key, a.value))
)
$$;


--
-- Name: FUNCTION pharmgkb_recommendation(lookupkeyarg text); Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON FUNCTION cpic.pharmgkb_recommendation(lookupkeyarg text) IS 'For a given genotype lookup JSON key, give the matching recommendations for all available drugs';


--
-- Name: cpic_id; Type: SEQUENCE; Schema: cpic; Owner: -
--

CREATE SEQUENCE cpic.cpic_id
    START WITH 110000
    INCREMENT BY 1
    NO MINVALUE
    NO MAXVALUE
    CACHE 1;




--
-- Name: drug; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.drug (
    drugid character varying(20) NOT NULL,
    name text NOT NULL,
    clinpgxid character varying(20),
    rxnormid character varying(20),
    drugbankid character varying(20),
    atcid text[],
    umlscui character varying(20),
    flowchart text,
    version integer DEFAULT 1,
    guidelineid integer
);


--
-- Name: TABLE drug; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.drug IS 'A clinically-used drug.';


--
-- Name: COLUMN drug.drugid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.drug.drugid IS 'A unique identifier for this drug in the form "source:id" where source is some outside knowledge resource and id is their identifier, primary key';


--
-- Name: COLUMN drug.name; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.drug.name IS 'The generic name for this drug, lower-cased, required';


--
-- Name: COLUMN drug.clinpgxid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.drug.clinpgxid IS 'The ClinPGx ID for this drug, optional';


--
-- Name: COLUMN drug.rxnormid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.drug.rxnormid IS 'The RxNorm ID for this drug, optional';


--
-- Name: COLUMN drug.drugbankid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.drug.drugbankid IS 'The DrugBank ID for this drug, optional';


--
-- Name: COLUMN drug.atcid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.drug.atcid IS 'One or more ATC IDs for this drug in an array, optional';


--
-- Name: COLUMN drug.umlscui; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.drug.umlscui IS 'The UMLS Concept Unique ID for this drug, optional';


--
-- Name: COLUMN drug.flowchart; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.drug.flowchart IS 'URL for the flow chart image of this drug';


--
-- Name: COLUMN drug.guidelineid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.drug.guidelineid IS 'The guideline this drug is part of a guideline, null means not a part of any guideline';


--
-- Name: guideline; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.guideline (
    id integer DEFAULT nextval('cpic.cpic_id'::regclass) NOT NULL,
    version integer DEFAULT 1,
    name text NOT NULL,
    url text,
    genes text[],
    notesonusage text,
    clinpgxid text
);


--
-- Name: TABLE guideline; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.guideline IS 'A guideline for a drug or group of drugs';


--
-- Name: COLUMN guideline.id; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.guideline.id IS 'A synthetic numerical ID, primary key';


--
-- Name: COLUMN guideline.version; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.guideline.version IS 'The version number, iterates on modification';


--
-- Name: COLUMN guideline.name; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.guideline.name IS 'The name (title) of this guideline, required';


--
-- Name: COLUMN guideline.url; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.guideline.url IS 'The URL of this guideline on the cpicpgx.org domain, optional';


--
-- Name: COLUMN guideline.genes; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.guideline.genes IS 'The subject genes of this guideline';


--
-- Name: COLUMN guideline.notesonusage; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.guideline.notesonusage IS 'Notes about using a particular guideline within this system. This may include. You may find information here when data for a guideline seems missing or incomplete.';


--
-- Name: COLUMN guideline.clinpgxid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.guideline.clinpgxid IS 'The accession ID in ClinPGx for the guideline';


--
-- Name: recommendation; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.recommendation (
    id integer DEFAULT nextval('cpic.cpic_id'::regclass) NOT NULL,
    guidelineid integer,
    drugid character varying(20),
    implications jsonb,
    drugrecommendation text,
    classification character varying(20),
    phenotypes jsonb,
    activityscore jsonb,
    allelestatus jsonb,
    lookupkey jsonb,
    population text,
    comments text,
    version integer DEFAULT 1,
    dosinginformation boolean DEFAULT false,
    alternatedrugavailable boolean DEFAULT false,
    otherprescribingguidance boolean DEFAULT false
);


--
-- Name: TABLE recommendation; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.recommendation IS 'Recommendations for a gene result pulled from a guideline';


--
-- Name: COLUMN recommendation.id; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.recommendation.id IS 'A synthetic numerical ID, auto-assigned, primary key';


--
-- Name: COLUMN recommendation.guidelineid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.recommendation.guidelineid IS 'The guideline this recommendation appears in';


--
-- Name: COLUMN recommendation.drugid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.recommendation.drugid IS 'The drug this recommendation is for';


--
-- Name: COLUMN recommendation.implications; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.recommendation.implications IS 'Implications for phenotypic measures, this is a JSON mapping of gene to implication';


--
-- Name: COLUMN recommendation.drugrecommendation; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.recommendation.drugrecommendation IS 'Dosing or therapeutic recommendations, depending on particular drug';


--
-- Name: COLUMN recommendation.classification; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.recommendation.classification IS 'Classification of recommendations, described in supplementary meterial';


--
-- Name: COLUMN recommendation.phenotypes; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.recommendation.phenotypes IS 'Phenotypes that this recommendation applies to, this is a JSON mapping of gene to phenotype';


--
-- Name: COLUMN recommendation.activityscore; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.recommendation.activityscore IS 'Activity score that this recommendation applies to, this is a JSON mapping of gene to score value';


--
-- Name: COLUMN recommendation.allelestatus; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.recommendation.allelestatus IS 'Whether or not an allele is present, used mainly for HLA genes, and used for recommendation lookups. This is a JSON mapping of gene to allele status (positive/negative)';


--
-- Name: COLUMN recommendation.lookupkey; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.recommendation.lookupkey IS 'A key to use for finding a specific recommendation. Made of a JSON object of gene symbol to key value. The key value can be one of phenotype, activity score, or allele status depending on the gene.';


--
-- Name: COLUMN recommendation.population; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.recommendation.population IS 'The population this recommendation is applicable to';


--
-- Name: COLUMN recommendation.comments; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.recommendation.comments IS 'Optional comments about the recommendation';


--
-- Name: COLUMN recommendation.dosinginformation; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.recommendation.dosinginformation IS 'The guideline recommends a dose adjustment based on genetic variants or phenotypes (e.g. "poor metabolizers") as a primary course of action. However, the guideline may also describe extenuating circumstances where this action is not appropriate.';


--
-- Name: COLUMN recommendation.alternatedrugavailable; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.recommendation.alternatedrugavailable IS 'The guideline recommends that an alternate drug be selected for patients based on genetic variants or phenotypes (e.g. "poor metabolizers") as a primary course of action. However, the guideline may also describe extenuating circumstances where this action is not appropriate.';


--
-- Name: COLUMN recommendation.otherprescribingguidance; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.recommendation.otherprescribingguidance IS 'The guideline and other prescribing guidance not described as either dose adjustment or alternate drug.';


--
-- Name: recommendation_view; Type: VIEW; Schema: cpic; Owner: -
--

CREATE VIEW cpic.recommendation_view AS
 SELECT r.id AS recommendationid,
    r.lookupkey,
    d.name AS drugname,
    g.name AS guidelinename,
    g.url AS guidelineurl,
    r.implications,
    r.drugrecommendation,
    r.classification,
    r.phenotypes,
    r.activityscore,
    r.population,
    r.comments
   FROM ((cpic.recommendation r
     JOIN cpic.drug d ON (((r.drugid)::text = (d.drugid)::text)))
     JOIN cpic.guideline g ON ((r.guidelineid = g.id)));


--
-- Name: VIEW recommendation_view; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON VIEW cpic.recommendation_view IS 'A view to help find recommendation data when querying by the lookupKey';


--
-- Name: recommendation_lookup(text); Type: FUNCTION; Schema: cpic; Owner: -
--

CREATE FUNCTION cpic.recommendation_lookup(diplotypelookup text) RETURNS SETOF cpic.recommendation_view
    LANGUAGE sql STABLE SECURITY DEFINER
    AS $$
select * from cpic.recommendation_view where lookupkey <@ (
    select jsonb_object_agg(key, value) as lookupkey
    from (select lookupkey from cpic.diplotype where diplotypekey <@ diplotypelookup::jsonb) x,
        json_each(x.lookupkey)
)
$$;


--
-- Name: FUNCTION recommendation_lookup(diplotypelookup text); Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON FUNCTION cpic.recommendation_lookup(diplotypelookup text) IS 'This function helps translate diplotypes into recommendation data. This relies on the recommendation_view to gather and filter relevant information. The diplotypelookup parameter is a JSON object of gene symbol to JSON allele representation.';


--
-- Name: test_alert; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.test_alert (
    id integer DEFAULT nextval('cpic.cpic_id'::regclass) NOT NULL,
    population text,
    cdscontext text NOT NULL,
    genes text[],
    phenotype jsonb,
    activityscore jsonb,
    allelestatus jsonb,
    lookupkey jsonb,
    drugid character varying(20),
    alerttext text[] NOT NULL,
    version integer DEFAULT 1
);


--
-- Name: TABLE test_alert; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.test_alert IS 'Example CDS test alert language';


--
-- Name: COLUMN test_alert.id; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.test_alert.id IS 'A synthetic numerical ID, primary key';


--
-- Name: COLUMN test_alert.population; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.test_alert.population IS 'The population this test alert is applicable to: general, adult, pediatrics, unspecified';


--
-- Name: COLUMN test_alert.cdscontext; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.test_alert.cdscontext IS 'This should be either "Pre-test", "Post-test" or "No CDS". This field is non-null';


--
-- Name: COLUMN test_alert.genes; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.test_alert.genes IS 'One or more genes this test alert uses for trigger conditions';


--
-- Name: COLUMN test_alert.phenotype; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.test_alert.phenotype IS 'A JSON object of gene symbol keys to phenotype description';


--
-- Name: COLUMN test_alert.activityscore; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.test_alert.activityscore IS 'A JSON object of gene symbol keys to gene activity score';


--
-- Name: COLUMN test_alert.allelestatus; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.test_alert.allelestatus IS 'Whether or not an allele is present, used mainly for HLA genes. This is a JSON mapping of gene to allele status (positive/negative)';


--
-- Name: COLUMN test_alert.lookupkey; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.test_alert.lookupkey IS 'A key to use for finding a specific test alert. Made of a JSON object of gene symbol to key value. The key value can be one of phenotype, activity score, or allele status depending on the gene.';


--
-- Name: COLUMN test_alert.drugid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.test_alert.drugid IS 'The ID of a drug this alert text is for';


--
-- Name: COLUMN test_alert.alerttext; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.test_alert.alerttext IS 'An array of one or more pieces of alert text';


--
-- Name: test_alert_view; Type: VIEW; Schema: cpic; Owner: -
--

CREATE VIEW cpic.test_alert_view AS
 SELECT t.id AS testalertid,
    t.lookupkey,
    d.name AS drugname,
    t.population,
    t.alerttext,
    t.cdscontext
   FROM (cpic.test_alert t
     JOIN cpic.drug d ON (((t.drugid)::text = (d.drugid)::text)));


--
-- Name: VIEW test_alert_view; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON VIEW cpic.test_alert_view IS 'A view to help find test alert data when querying by the lookupKey';


--
-- Name: test_alert_lookup(text); Type: FUNCTION; Schema: cpic; Owner: -
--

CREATE FUNCTION cpic.test_alert_lookup(lookup text) RETURNS SETOF cpic.test_alert_view
    LANGUAGE sql STABLE SECURITY DEFINER
    AS $$
select * from cpic.test_alert_view where lookupkey <@ (
    select jsonb_object_agg(key, value) as lookupkey
    from (select lookupkey from cpic.diplotype where diplotypekey <@ lookup::jsonb) x,
        json_each(x.lookupkey)
)
$$;


--
-- Name: FUNCTION test_alert_lookup(lookup text); Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON FUNCTION cpic.test_alert_lookup(lookup text) IS 'This function helps translate diplotypes into test alert data. This relies on the test_alert_view to gather and filter relevant information. The lookup parameter is a JSON object of gene symbol to JSON allele representation.';


--
-- Name: allele; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.allele (
    id integer DEFAULT nextval('cpic.cpic_id'::regclass) NOT NULL,
    version integer DEFAULT 1,
    genesymbol character varying(50) NOT NULL,
    name text NOT NULL,
    functionalstatus text,
    clinicalfunctionalstatus text,
    clinicalfunctionalsubstrate text,
    activityvalue character varying(50),
    definitionid integer NOT NULL,
    citations text[],
    strength text,
    functioncomments text,
    findings text,
    frequency jsonb,
    inferredfrequency boolean DEFAULT false
);


--
-- Name: TABLE allele; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.allele IS 'An allele of a gene';


--
-- Name: COLUMN allele.id; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele.id IS 'A synthetic numerical ID, auto-assigned, primary key';


--
-- Name: COLUMN allele.version; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele.version IS 'The version number, iterates on modification';


--
-- Name: COLUMN allele.genesymbol; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele.genesymbol IS 'The HGNC symbol of the gene the allele is for, required';


--
-- Name: COLUMN allele.name; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele.name IS 'The name of this allele, required';


--
-- Name: COLUMN allele.functionalstatus; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele.functionalstatus IS 'The functional phenotype of this allele';


--
-- Name: COLUMN allele.clinicalfunctionalstatus; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele.clinicalfunctionalstatus IS 'The functional phenotype of this allele used for clinical systems';


--
-- Name: COLUMN allele.clinicalfunctionalsubstrate; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele.clinicalfunctionalsubstrate IS 'Allele clinical function substrate specificity, optional';


--
-- Name: COLUMN allele.activityvalue; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele.activityvalue IS 'Descriptor of activity score, optional';


--
-- Name: COLUMN allele.definitionid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele.definitionid IS 'The reference to the definition for this allele';


--
-- Name: COLUMN allele.citations; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele.citations IS 'An array of PubMed IDs use as citations for this functional assignment';


--
-- Name: COLUMN allele.strength; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele.strength IS 'The strength of evidence';


--
-- Name: COLUMN allele.functioncomments; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele.functioncomments IS 'Comments this functional assignment of this allele';


--
-- Name: COLUMN allele.inferredfrequency; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele.inferredfrequency IS 'Indicates (with "true") that the frequencies for this allele have been inferred by an algorithm that aggregates the frequencies for other alleles of this gene and is not based on direct data, defaults to false, should only be 1 per gene';


--
-- Name: allele_definition; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.allele_definition (
    id integer DEFAULT nextval('cpic.cpic_id'::regclass) NOT NULL,
    version integer DEFAULT 1,
    genesymbol character varying(50) NOT NULL,
    name text NOT NULL,
    pharmvarid character varying(50),
    matchesreferencesequence boolean DEFAULT false,
    structuralvariation boolean DEFAULT false
);


--
-- Name: TABLE allele_definition; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.allele_definition IS 'The definition for an allele of a gene';


--
-- Name: COLUMN allele_definition.id; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele_definition.id IS 'A synthetic numerical ID, auto-assigned, primary key';


--
-- Name: COLUMN allele_definition.genesymbol; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele_definition.genesymbol IS 'The HGNC symbol of the gene the allele is for, required';


--
-- Name: COLUMN allele_definition.name; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele_definition.name IS 'The name of this allele, required';


--
-- Name: COLUMN allele_definition.pharmvarid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele_definition.pharmvarid IS 'The PharmVar core allele ID for this allele';


--
-- Name: COLUMN allele_definition.matchesreferencesequence; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele_definition.matchesreferencesequence IS 'Indicates (with "true") the variants that define the named allele will match the reference sequence for the gene, defaults to false, should only be 1 per gene';


--
-- Name: COLUMN allele_definition.structuralvariation; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele_definition.structuralvariation IS 'Indicates whether this allele definition is a structural variant, default is false. If true, look in the pharmvarid field for the PharmVar ID that defines the structural variation.';


--
-- Name: allele_frequency; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.allele_frequency (
    alleleid integer NOT NULL,
    population integer NOT NULL,
    frequency numeric,
    label text,
    version integer DEFAULT 1
);


--
-- Name: TABLE allele_frequency; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.allele_frequency IS 'A frequency observation for a particular allele in a particular population';


--
-- Name: COLUMN allele_frequency.alleleid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele_frequency.alleleid IS 'The ID of the allele for this observation';


--
-- Name: COLUMN allele_frequency.population; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele_frequency.population IS 'The ID of the population for this observation';


--
-- Name: COLUMN allele_frequency.frequency; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele_frequency.frequency IS 'The numeric representation of this frequency';


--
-- Name: COLUMN allele_frequency.label; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele_frequency.label IS 'The textual label for this frequency, "-" means no observation made';


--
-- Name: COLUMN allele_frequency.version; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele_frequency.version IS 'The version number, iterates on modification';


--
-- Name: pair; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.pair (
    pairid integer DEFAULT nextval('cpic.cpic_id'::regclass) NOT NULL,
    genesymbol character varying(20),
    drugid character varying(20),
    guidelineid integer,
    usedforrecommendation boolean DEFAULT false,
    version integer DEFAULT 1,
    cpiclevel text NOT NULL,
    clinpgxlevel character varying(5),
    pgxtesting text,
    citations text[],
    removed boolean DEFAULT false,
    removeddate date,
    removedreason text,
    CONSTRAINT valid_cpiclevel_check CHECK ((cpiclevel = ANY (ARRAY[('A'::character varying)::text, ('A/B'::character varying)::text, ('B'::character varying)::text, ('B/C'::character varying)::text, ('C'::character varying)::text, ('C/D'::character varying)::text, ('D'::character varying)::text, ('Retired'::character varying)::text]))),
    CONSTRAINT valid_pgkblevel_check CHECK (((clinpgxlevel)::text = ANY (ARRAY[('1A'::character varying)::text, ('1B'::character varying)::text, ('2A'::character varying)::text, ('2B'::character varying)::text, ('3'::character varying)::text, ('4'::character varying)::text]))),
    CONSTRAINT valid_pmids CHECK ((array_to_string(citations, ''::text) ~ '\d+'::text)),
    CONSTRAINT valid_used_check CHECK (((NOT usedforrecommendation) OR (guidelineid IS NOT NULL)))
);


--
-- Name: TABLE pair; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.pair IS 'A pair of a gene and a drug that is notable to CPIC';


--
-- Name: COLUMN pair.pairid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair.pairid IS 'A synthetic numerical id, automatically assigned, primary key';


--
-- Name: COLUMN pair.genesymbol; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair.genesymbol IS 'The HGNC symbol of the gene in this pair, required';


--
-- Name: COLUMN pair.drugid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair.drugid IS 'The ID of the drug in this pair, required';


--
-- Name: COLUMN pair.guidelineid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair.guidelineid IS 'The ID of a guideline this pair is described in, optional';


--
-- Name: COLUMN pair.usedforrecommendation; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair.usedforrecommendation IS 'Whether the gene is used for recommendation lookup for the drug if this pair is part of a guideline, default false';


--
-- Name: COLUMN pair.version; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair.version IS 'The version number, iterates on modification';


--
-- Name: COLUMN pair.cpiclevel; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair.cpiclevel IS 'The CPIC level of this pair, required';


--
-- Name: COLUMN pair.clinpgxlevel; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair.clinpgxlevel IS 'The top level of PharmGKB Clinical Annotation for this pair, optional';


--
-- Name: COLUMN pair.pgxtesting; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair.pgxtesting IS 'The top level of PGx testing recommendation from PharmGKB label annotations, optional';


--
-- Name: COLUMN pair.citations; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair.citations IS 'The PMID citations in an array for this pair, optional';


--
-- Name: COLUMN pair.removed; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair.removed IS 'Has this pair been "removed", eg is no longer a valid pair, default false';


--
-- Name: COLUMN pair.removeddate; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair.removeddate IS 'If removed, when was this pair "removed"';


--
-- Name: COLUMN pair.removedreason; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair.removedreason IS 'If removed, why was this pair "removed"';


--
-- Name: allele_guideline_view; Type: VIEW; Schema: cpic; Owner: -
--

CREATE VIEW cpic.allele_guideline_view AS
 SELECT DISTINCT a.genesymbol,
    a.name AS allele_name,
    g.name AS guideline_name,
    g.url AS guideline_url
   FROM ((cpic.allele a
     JOIN cpic.pair p ON (((a.genesymbol)::text = (p.genesymbol)::text)))
     JOIN cpic.guideline g ON ((g.id = p.guidelineid)))
  WHERE (a.clinicalfunctionalstatus IS NOT NULL);


--
-- Name: VIEW allele_guideline_view; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON VIEW cpic.allele_guideline_view IS 'A combination of alleles and the guidelines they appear in';


--
-- Name: COLUMN allele_guideline_view.genesymbol; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele_guideline_view.genesymbol IS 'The HGNC symbol of the gene';


--
-- Name: COLUMN allele_guideline_view.allele_name; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele_guideline_view.allele_name IS 'The name of the allele';


--
-- Name: COLUMN allele_guideline_view.guideline_name; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele_guideline_view.guideline_name IS 'The name of the guideline this allele appears in';


--
-- Name: COLUMN allele_guideline_view.guideline_url; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele_guideline_view.guideline_url IS 'The URL to the guideline';


--
-- Name: allele_location_value; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.allele_location_value (
    alleledefinitionid integer NOT NULL,
    locationid integer NOT NULL,
    variantallele text NOT NULL,
    version integer DEFAULT 1
);


--
-- Name: TABLE allele_location_value; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.allele_location_value IS 'The change at a specific location for a specific allele';


--
-- Name: COLUMN allele_location_value.alleledefinitionid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele_location_value.alleledefinitionid IS 'The reference to the allele this variant is on';


--
-- Name: COLUMN allele_location_value.locationid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele_location_value.locationid IS 'The reference to the location this variant is for';


--
-- Name: COLUMN allele_location_value.variantallele; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele_location_value.variantallele IS 'The allele of this location for the allele';


--
-- Name: COLUMN allele_location_value.version; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele_location_value.version IS 'The version number, iterates on modification';


--
-- Name: change_log; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.change_log (
    date date NOT NULL,
    type text NOT NULL,
    entityid text,
    note text NOT NULL,
    version integer DEFAULT 1,
    deployedrelease text
);


--
-- Name: TABLE change_log; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.change_log IS 'A dated freeform text description of a change made to a type of information and optionally for a specific entity';


--
-- Name: COLUMN change_log.date; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.change_log.date IS 'The date the log note is applicable';


--
-- Name: COLUMN change_log.type; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.change_log.type IS 'The type of data this log message is about';


--
-- Name: COLUMN change_log.entityid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.change_log.entityid IS 'Optional, the specific entity this note is about. For example, could be a gene symbol or drug ID';


--
-- Name: COLUMN change_log.note; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.change_log.note IS 'The freeform text note about what the change was';


--
-- Name: COLUMN change_log.version; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.change_log.version IS 'The version number, iterates on modification';


--
-- Name: COLUMN change_log.deployedrelease; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.change_log.deployedrelease IS 'The release this change was deployed with';


--
-- Name: gene; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.gene (
    symbol character varying(20) NOT NULL,
    chr character varying(20),
    genesequenceid text,
    proteinsequenceid text,
    chromosequenceid text,
    mrnasequenceid text,
    hgncid text,
    ncbiid text,
    ensemblid text,
    clinpgxid text,
    frequencymethods text,
    lookupmethod text DEFAULT 'PHENOTYPE'::text,
    version integer DEFAULT 1,
    notesondiplotype text,
    url text,
    functionmethods text,
    notesonallelenaming text,
    includephenotypefrequencies boolean DEFAULT true NOT NULL,
    includediplotypefrequencies boolean DEFAULT true NOT NULL,
    CONSTRAINT gene_chr_check CHECK (((chr)::text ~ '^chr\S+$'::text)),
    CONSTRAINT gene_chromosequenceid_check CHECK ((chromosequenceid ~ '^(NC_\S+)?$'::text)),
    CONSTRAINT gene_ensemblid_check CHECK ((ensemblid ~ '^(ENSG\d+)?$'::text)),
    CONSTRAINT gene_genesequenceid_check CHECK ((genesequenceid ~ '^(NG_\S+)?$'::text)),
    CONSTRAINT gene_hgncid_check CHECK ((hgncid ~ '^(HGNC:\d+)?$'::text)),
    CONSTRAINT gene_mrnasequenceid_check CHECK ((mrnasequenceid ~ '^(NM_\S+)?$'::text)),
    CONSTRAINT gene_pharmgkbid_check CHECK ((clinpgxid ~ '^(PA\d+)?$'::text)),
    CONSTRAINT gene_proteinsequenceid_check CHECK ((proteinsequenceid ~ '^(NP_\S+)?$'::text))
);


--
-- Name: TABLE gene; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.gene IS 'Gene information with a primary key of the approved HGNC symbol for the gene. This means any gene used in the table must be approved by HGNC.';


--
-- Name: COLUMN gene.symbol; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene.symbol IS 'Approved HGNC symbol, primary key.';


--
-- Name: COLUMN gene.chr; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene.chr IS 'Chromosome symbol. In the form chr##, where ## is the number or X/Y.';


--
-- Name: COLUMN gene.genesequenceid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene.genesequenceid IS 'The RefSeq ID for the sequence that represents this gene, starts with "NG_". No version suffix.';


--
-- Name: COLUMN gene.proteinsequenceid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene.proteinsequenceid IS 'The RefSeq ID for the sequence that represents the protein product of this gene, starts with "NP_". No version suffix.';


--
-- Name: COLUMN gene.chromosequenceid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene.chromosequenceid IS 'The RefSeq ID for the sequence that represents the chromosome this gene is on, starts with "NC_". No version suffix.';


--
-- Name: COLUMN gene.mrnasequenceid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene.mrnasequenceid IS 'The RefSeq ID for the sequence that represents the translation of this gene, starts with "NM_". No version suffix.';


--
-- Name: COLUMN gene.hgncid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene.hgncid IS 'The HGNC numerical ID number for this gene prefixed by "HGNC:"';


--
-- Name: COLUMN gene.ncbiid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene.ncbiid IS 'The NCBI Gene (Entrez) ID number for this gene';


--
-- Name: COLUMN gene.ensemblid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene.ensemblid IS 'The Ensembl ID for this gene';


--
-- Name: COLUMN gene.clinpgxid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene.clinpgxid IS 'The ID for this gene in ClinPGx';


--
-- Name: COLUMN gene.frequencymethods; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene.frequencymethods IS 'Text documentation of the methods and caveats for allele frequency data';


--
-- Name: COLUMN gene.lookupmethod; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene.lookupmethod IS 'The way to lookup information about diplotypes of this gene, should use ACTIVITY_SCORE, PHENOTYPE, or ALLELE_STATUS';


--
-- Name: COLUMN gene.notesondiplotype; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene.notesondiplotype IS 'Optional notes about the diplotypes of the gene';


--
-- Name: COLUMN gene.includephenotypefrequencies; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene.includephenotypefrequencies IS 'if allele frequencies exist for this gene, whether to calculate and display phenotype-level frequencies. a true value does not imply existence frequency data';


--
-- Name: COLUMN gene.includediplotypefrequencies; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene.includediplotypefrequencies IS 'if allele frequencies exist for this gene, whether to calculate and display diplotype-level frequencies. a true value does not imply existence frequency data';


--
-- Name: change_log_view; Type: VIEW; Schema: cpic; Owner: -
--

CREATE VIEW cpic.change_log_view AS
 WITH x AS (
         SELECT gene.symbol AS entityid,
            gene.symbol AS entityname
           FROM cpic.gene
        UNION ALL
         SELECT drug.drugid AS entityid,
            drug.name AS entityname
           FROM cpic.drug
        )
 SELECT l.date,
    l.type,
    x.entityname,
    l.note,
    l.deployedrelease
   FROM (cpic.change_log l
     LEFT JOIN x ON ((l.entityid = (x.entityid)::text)));


--
-- Name: VIEW change_log_view; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON VIEW cpic.change_log_view IS 'This view of the change_log table add the entity name to make it more readable';


--
-- Name: gene_result; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.gene_result (
    id integer DEFAULT nextval('cpic.cpic_id'::regclass) NOT NULL,
    genesymbol character varying(50) NOT NULL,
    result text NOT NULL,
    activityscore text,
    ehrpriority text,
    consultationtext text,
    version integer DEFAULT 1,
    frequency jsonb
);


--
-- Name: TABLE gene_result; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.gene_result IS 'Possible phenotype values for a gene. The gene + phenotype + activity score should be unique.';


--
-- Name: COLUMN gene_result.id; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene_result.id IS 'A synthetic numerical ID, auto-assigned, primary key';


--
-- Name: COLUMN gene_result.genesymbol; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene_result.genesymbol IS 'The HGNC symbol of the gene in this pair, required';


--
-- Name: COLUMN gene_result.result; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene_result.result IS 'The result for a gene, can either be a phenotype or "allele status" depending on the lookup method for the gene (see lookupMethod in gene table), required';


--
-- Name: COLUMN gene_result.activityscore; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene_result.activityscore IS 'Activity score, optional';


--
-- Name: COLUMN gene_result.ehrpriority; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene_result.ehrpriority IS 'EHR Priority Result, optional';


--
-- Name: COLUMN gene_result.consultationtext; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene_result.consultationtext IS 'Consultation (Interpretation) Text Provided with Test Result';


--
-- Name: COLUMN gene_result.frequency; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene_result.frequency IS 'JSON map of frequencies for this gene result with keys being biogeographical groups';


--
-- Name: gene_result_diplotype; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.gene_result_diplotype (
    id integer DEFAULT nextval('cpic.cpic_id'::regclass) NOT NULL,
    functionphenotypeid integer NOT NULL,
    diplotype text NOT NULL,
    diplotypekey jsonb NOT NULL,
    frequency jsonb
);


--
-- Name: TABLE gene_result_diplotype; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.gene_result_diplotype IS 'Specific diplotypes that are associated with a gene result. This table is a child of gene_result_lookup and distantly of gene_result';


--
-- Name: COLUMN gene_result_diplotype.id; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene_result_diplotype.id IS 'A synthetic numerical ID, auto-assigned, primary key';


--
-- Name: COLUMN gene_result_diplotype.functionphenotypeid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene_result_diplotype.functionphenotypeid IS 'An ID referencing a gene_result_lookup record, required';


--
-- Name: COLUMN gene_result_diplotype.diplotype; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene_result_diplotype.diplotype IS 'A diplotype for the gene in the form Allele1/Allele2, required';


--
-- Name: COLUMN gene_result_diplotype.diplotypekey; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene_result_diplotype.diplotypekey IS 'A normalized JSON version of the diplotype for use in lookups. Should be an object with the allele names as properties and the counts as the values. Required';


--
-- Name: gene_result_lookup; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.gene_result_lookup (
    id integer DEFAULT nextval('cpic.cpic_id'::regclass) NOT NULL,
    phenotypeid integer NOT NULL,
    lookupkey jsonb NOT NULL,
    function1 text,
    function2 text,
    activityvalue1 text,
    activityvalue2 text,
    totalactivityscore text,
    description text
);


--
-- Name: TABLE gene_result_lookup; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.gene_result_lookup IS 'Gene descriptions that, when combined, link to a gene result. This table is a child of gene_result.';


--
-- Name: COLUMN gene_result_lookup.id; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene_result_lookup.id IS 'A synthetic numerical ID, auto-assigned, primary key';


--
-- Name: COLUMN gene_result_lookup.phenotypeid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene_result_lookup.phenotypeid IS 'An ID referencing the gene_result this is associated with, required';


--
-- Name: COLUMN gene_result_lookup.lookupkey; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene_result_lookup.lookupkey IS 'A normalized JSON format of the data used to lookup a diplotype. The keys of this field are either the functions, activity scores, or allele statuses depending on what the gene requires. Required.';


--
-- Name: COLUMN gene_result_lookup.function1; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene_result_lookup.function1 IS 'The first allele function';


--
-- Name: COLUMN gene_result_lookup.function2; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene_result_lookup.function2 IS 'The second allele function';


--
-- Name: COLUMN gene_result_lookup.activityvalue1; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene_result_lookup.activityvalue1 IS 'The activity score for the first allele function';


--
-- Name: COLUMN gene_result_lookup.activityvalue2; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene_result_lookup.activityvalue2 IS 'The activity score for the second allele function';


--
-- Name: COLUMN gene_result_lookup.totalactivityscore; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene_result_lookup.totalactivityscore IS 'The sum activity score for the functions';


--
-- Name: COLUMN gene_result_lookup.description; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene_result_lookup.description IS 'A description of the diplotypes associated with this phenotype';


--
-- Name: diplotype; Type: VIEW; Schema: cpic; Owner: -
--

CREATE VIEW cpic.diplotype AS
 SELECT gp.genesymbol,
    d.diplotype,
    pf.function1,
    pf.function2,
    pf.activityvalue1,
    pf.activityvalue2,
    pf.totalactivityscore,
    pf.description,
    d.diplotypekey,
    gp.result AS generesult,
    gp.ehrpriority,
    gp.consultationtext,
    json_build_object(gp.genesymbol,
        CASE
            WHEN (g.lookupmethod = 'ACTIVITY_SCORE'::text) THEN pf.totalactivityscore
            ELSE gp.result
        END) AS lookupkey
   FROM (((cpic.gene_result_diplotype d
     JOIN cpic.gene_result_lookup pf ON ((d.functionphenotypeid = pf.id)))
     JOIN cpic.gene_result gp ON ((pf.phenotypeid = gp.id)))
     JOIN cpic.gene g ON (((gp.genesymbol)::text = (g.symbol)::text)));


--
-- Name: VIEW diplotype; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON VIEW cpic.diplotype IS 'A combination of gene_result and gene_result_diplotype that allows you to easily query by diplotype and see the phenotype-related data for it';


--
-- Name: COLUMN diplotype.genesymbol; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.diplotype.genesymbol IS 'The HGNC symbol of the gene in this pair, required';


--
-- Name: COLUMN diplotype.diplotype; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.diplotype.diplotype IS 'A diplotype for the gene in the form Allele1/Allele2, required';


--
-- Name: COLUMN diplotype.function1; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.diplotype.function1 IS 'A functional assignment of one of the alleles, optional';


--
-- Name: COLUMN diplotype.function2; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.diplotype.function2 IS 'A functional assignment of one of the alleles, optional';


--
-- Name: COLUMN diplotype.activityvalue1; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.diplotype.activityvalue1 IS 'An activity value assignment of one of the alleles, optional';


--
-- Name: COLUMN diplotype.activityvalue2; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.diplotype.activityvalue2 IS 'An activity value assignment of one of the alleles, optional';


--
-- Name: COLUMN diplotype.totalactivityscore; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.diplotype.totalactivityscore IS 'The total Activity Score number, optional';


--
-- Name: COLUMN diplotype.description; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.diplotype.description IS 'The long-form description of the diplotype';


--
-- Name: COLUMN diplotype.diplotypekey; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.diplotype.diplotypekey IS 'A normalized version of the diplotype that can be used for DB lookups';


--
-- Name: COLUMN diplotype.generesult; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.diplotype.generesult IS 'The result for a gene, can either be a phenotype or "allele status" depending on the lookup method for the gene (see lookupMethod in gene table), required';


--
-- Name: COLUMN diplotype.lookupkey; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.diplotype.lookupkey IS 'A normalized version of the gene phenotype that can be used for recommendation or test alert lookup';


--
-- Name: data_progress; Type: VIEW; Schema: cpic; Owner: -
--

CREATE VIEW cpic.data_progress AS
 SELECT 'Gene'::text AS object_class,
    'Allele Definition Data'::text AS data_type,
    allele_definition.genesymbol AS object_name,
    count(*) AS n
   FROM cpic.allele_definition
  GROUP BY allele_definition.genesymbol
UNION ALL
 SELECT 'Gene'::text AS object_class,
    'Allele Functionality Data'::text AS data_type,
    a.genesymbol AS object_name,
    count(*) AS n
   FROM cpic.allele a
  WHERE (a.clinicalfunctionalstatus IS NOT NULL)
  GROUP BY a.genesymbol
UNION ALL
 SELECT 'Gene'::text AS object_class,
    'Diplotype to Phenotype Data'::text AS data_type,
    diplotype.genesymbol AS object_name,
    count(*) AS n
   FROM cpic.diplotype
  GROUP BY diplotype.genesymbol
UNION ALL
 SELECT 'Gene'::text AS object_class,
    'Frequency Data'::text AS data_type,
    a.genesymbol AS object_name,
    count(*) AS n
   FROM (cpic.allele_frequency f
     JOIN cpic.allele a ON ((f.alleleid = a.id)))
  GROUP BY a.genesymbol
UNION ALL
 SELECT 'Gene'::text AS object_class,
    'Gene CDS Data'::text AS data_type,
    gene_result.genesymbol AS object_name,
    count(*) AS n
   FROM cpic.gene_result
  WHERE (gene_result.consultationtext IS NOT NULL)
  GROUP BY gene_result.genesymbol
UNION ALL
 SELECT 'Gene'::text AS object_class,
    'Gene Phenotype Data'::text AS data_type,
    g.genesymbol AS object_name,
    count(*) AS n
   FROM (cpic.gene_result g
     JOIN cpic.gene_result_lookup pf ON ((g.id = pf.phenotypeid)))
  GROUP BY g.genesymbol
UNION ALL
 SELECT 'Gene'::text AS object_class,
    'PharmVar Allele IDs'::text AS data_type,
    a.genesymbol AS object_name,
    count(*) AS n
   FROM cpic.allele_definition a
  WHERE (a.pharmvarid IS NOT NULL)
  GROUP BY a.genesymbol
UNION ALL
 SELECT 'Drug'::text AS object_class,
    'Flowcharts'::text AS data_type,
    drug.name AS object_name,
    count(*) AS n
   FROM cpic.drug
  WHERE (drug.flowchart IS NOT NULL)
  GROUP BY drug.name
UNION ALL
 SELECT 'Drug'::text AS object_class,
    'Table 2 Recommendations'::text AS data_type,
    d.name AS object_name,
    count(DISTINCT r.id) AS n
   FROM (cpic.recommendation r
     JOIN cpic.drug d ON (((r.drugid)::text = (d.drugid)::text)))
  GROUP BY d.name
UNION ALL
 SELECT 'Drug'::text AS object_class,
    'Drug Test Alerts'::text AS data_type,
    d.name AS object_name,
    count(DISTINCT t.id) AS n
   FROM (cpic.test_alert t
     JOIN cpic.drug d ON (((t.drugid)::text = (d.drugid)::text)))
  GROUP BY d.name
UNION ALL
 SELECT 'Drug'::text AS object_class,
    'Guideline'::text AS data_type,
    d.name AS object_name,
    count(DISTINCT g.id) AS n
   FROM ((cpic.guideline g
     JOIN cpic.pair p ON ((g.id = p.guidelineid)))
     JOIN cpic.drug d ON (((p.drugid)::text = (d.drugid)::text)))
  GROUP BY d.name;


--
-- Name: file_artifact; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.file_artifact (
    id integer DEFAULT nextval('cpic.cpic_id'::regclass) NOT NULL,
    entityids text[],
    type text NOT NULL,
    filename text NOT NULL,
    url text
);


--
-- Name: TABLE file_artifact; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.file_artifact IS 'File artifact information. Each entry is a different file artifact generated by the system';


--
-- Name: COLUMN file_artifact.id; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.file_artifact.id IS 'A synthetic numerical ID, auto-assigned, primary key';


--
-- Name: COLUMN file_artifact.entityids; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.file_artifact.entityids IS 'The IDs of the entities the file is for, required';


--
-- Name: COLUMN file_artifact.type; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.file_artifact.type IS 'The type of file';


--
-- Name: COLUMN file_artifact.filename; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.file_artifact.filename IS 'The name of the file (no path)';


--
-- Name: COLUMN file_artifact.url; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.file_artifact.url IS 'The permanent URL of the current version of this file';


--
-- Name: file_artifact_history; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.file_artifact_history (
    id integer DEFAULT nextval('cpic.cpic_id'::regclass) NOT NULL,
    fileid integer NOT NULL,
    source text NOT NULL,
    changedate timestamp without time zone DEFAULT CURRENT_TIMESTAMP NOT NULL,
    changemessage text
);


--
-- Name: TABLE file_artifact_history; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.file_artifact_history IS 'History information for a related file artifact';


--
-- Name: COLUMN file_artifact_history.id; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.file_artifact_history.id IS 'A synthetic numerical ID, auto-assigned, primary key';


--
-- Name: COLUMN file_artifact_history.fileid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.file_artifact_history.fileid IS 'The ID of the related File Artifact';


--
-- Name: COLUMN file_artifact_history.source; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.file_artifact_history.source IS 'Where this history message originated from';


--
-- Name: COLUMN file_artifact_history.changedate; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.file_artifact_history.changedate IS 'The date the change was applied';


--
-- Name: COLUMN file_artifact_history.changemessage; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.file_artifact_history.changemessage IS 'A message describing the change that occurred';


--
-- Name: file_note; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.file_note (
    type text NOT NULL,
    entityid text,
    note text NOT NULL,
    ordinal integer NOT NULL,
    version integer DEFAULT 1
);


--
-- Name: TABLE file_note; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.file_note IS 'An ordered note that should appear with the type of information specified';


--
-- Name: COLUMN file_note.type; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.file_note.type IS 'The type of information this note is about';


--
-- Name: COLUMN file_note.entityid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.file_note.entityid IS 'Optional, the specific entity this note is about. For example, could be a gene symbol or drug ID';


--
-- Name: COLUMN file_note.note; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.file_note.note IS 'The freeform text note about the type/entity';


--
-- Name: COLUMN file_note.ordinal; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.file_note.ordinal IS 'The index number for ordering notes of a given type/entity';


--
-- Name: COLUMN file_note.version; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.file_note.version IS 'The version number, iterates on modification';


--
-- Name: file_status; Type: VIEW; Schema: cpic; Owner: -
--

CREATE VIEW cpic.file_status AS
 SELECT a.id,
    a.entityids,
    a.type,
    a.filename,
    a.url,
    history.latest_change
   FROM (cpic.file_artifact a
     LEFT JOIN ( SELECT h.fileid,
            max(h.changedate) AS latest_change
           FROM cpic.file_artifact_history h
          GROUP BY h.fileid) history ON ((a.id = history.fileid)))
  ORDER BY a.type, a.filename;


--
-- Name: flyway_schema_history; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.flyway_schema_history (
    installed_rank integer NOT NULL,
    version character varying(50),
    description character varying(200) NOT NULL,
    type character varying(20) NOT NULL,
    script character varying(1000) NOT NULL,
    checksum integer,
    installed_by character varying(100) NOT NULL,
    installed_on timestamp without time zone DEFAULT now() NOT NULL,
    execution_time integer NOT NULL,
    success boolean NOT NULL
);


--
-- Name: guideline_summary_view; Type: VIEW; Schema: cpic; Owner: -
--

CREATE VIEW cpic.guideline_summary_view AS
 SELECT g.name AS guideline_name,
    g.url AS guideline_url,
    array_agg(DISTINCT d.name) AS drugs,
    jsonb_agg(DISTINCT jsonb_build_object('symbol', p.genesymbol, 'url', (('https://cpicpgx.org/gene/'::text || lower((p.genesymbol)::text)) || '/'::text))) AS genes
   FROM ((cpic.guideline g
     JOIN cpic.pair p ON ((g.id = p.guidelineid)))
     JOIN cpic.drug d ON (((p.drugid)::text = (d.drugid)::text)))
  GROUP BY g.name, g.url;


--
-- Name: VIEW guideline_summary_view; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON VIEW cpic.guideline_summary_view IS 'This view lists guidelines and the genes and drugs that are associated with them';


--
-- Name: COLUMN guideline_summary_view.guideline_name; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.guideline_summary_view.guideline_name IS 'The title of the guideline';


--
-- Name: COLUMN guideline_summary_view.guideline_url; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.guideline_summary_view.guideline_url IS 'The URL of the guideline on the CPIC website';


--
-- Name: COLUMN guideline_summary_view.drugs; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.guideline_summary_view.drugs IS 'An array of drug names associated with this guideline';


--
-- Name: COLUMN guideline_summary_view.genes; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.guideline_summary_view.genes IS 'An array of gene data associated with this guideline, each object will have a symbol and a URL for the gene on the CPIC website';


--
-- Name: pair_view; Type: VIEW; Schema: cpic; Owner: -
--

CREATE VIEW cpic.pair_view AS
 SELECT p.pairid,
    p.drugid,
    d.name AS drugname,
    p.genesymbol,
    g.name AS guidelinename,
    g.url AS guidelineurl,
    p.cpiclevel,
    p.clinpgxlevel,
    p.pgxtesting,
    p.citations AS pmids,
        CASE
            WHEN (p.usedforrecommendation AND (p.guidelineid IS NOT NULL)) THEN 'Yes'::text
            WHEN ((NOT p.usedforrecommendation) AND (p.guidelineid IS NOT NULL)) THEN 'No'::text
            ELSE 'n/a'::text
        END AS usedforrecommendation,
        CASE
            WHEN (p.guidelineid IS NULL) THEN true
            ELSE false
        END AS provisional
   FROM ((cpic.pair p
     JOIN cpic.drug d ON (((p.drugid)::text = (d.drugid)::text)))
     LEFT JOIN cpic.guideline g ON ((p.guidelineid = g.id)))
  WHERE (p.removed IS FALSE);


--
-- Name: VIEW pair_view; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON VIEW cpic.pair_view IS 'This pairs view combines information from the pair, drug, and guideline tables to make a more readable view of pair data. This also limits result to pairs which have NOT been removed.';


--
-- Name: COLUMN pair_view.pairid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair_view.pairid IS 'The primary key ID of this pair';


--
-- Name: COLUMN pair_view.drugid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair_view.drugid IS 'The ID of the drug in the pair';


--
-- Name: COLUMN pair_view.drugname; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair_view.drugname IS 'The name of the drug in the pair';


--
-- Name: COLUMN pair_view.genesymbol; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair_view.genesymbol IS 'The symbol of the drug in the pair';


--
-- Name: COLUMN pair_view.guidelinename; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair_view.guidelinename IS 'The name for the guideline of this pair';


--
-- Name: COLUMN pair_view.guidelineurl; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair_view.guidelineurl IS 'The URL for the guideline of this pair';


--
-- Name: COLUMN pair_view.cpiclevel; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair_view.cpiclevel IS 'The CPIC-assigned level of the pair';


--
-- Name: COLUMN pair_view.clinpgxlevel; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair_view.clinpgxlevel IS 'The top level of ClinPGx Summary Annotation of the pair';


--
-- Name: COLUMN pair_view.pgxtesting; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair_view.pgxtesting IS 'The testing level of the label annotation from ClinPGx for this pair';


--
-- Name: COLUMN pair_view.pmids; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair_view.pmids IS 'The PMIDs for guideline publications of this pair';


--
-- Name: COLUMN pair_view.provisional; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair_view.provisional IS 'The CPIC level assigned to this pair is provisional, true if this pair is not part of a guideline';


--
-- Name: population; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.population (
    id integer DEFAULT nextval('cpic.cpic_id'::regclass) NOT NULL,
    publicationid integer,
    ethnicity text NOT NULL,
    population text,
    populationinfo text,
    subjecttype text,
    subjectcount integer DEFAULT 0,
    version integer DEFAULT 1
);


--
-- Name: TABLE population; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.population IS 'A population description of a group of subjects';


--
-- Name: COLUMN population.id; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.population.id IS 'A synthetic primary key ID';


--
-- Name: COLUMN population.publicationid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.population.publicationid IS 'A reference to a publication';


--
-- Name: COLUMN population.ethnicity; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.population.ethnicity IS 'The major ethnicity grouping of this population';


--
-- Name: COLUMN population.population; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.population.population IS 'The descriptive name of this population, optional';


--
-- Name: COLUMN population.populationinfo; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.population.populationinfo IS 'Further information about this population, optional';


--
-- Name: COLUMN population.subjecttype; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.population.subjecttype IS 'Information about the types of subjects in this population';


--
-- Name: COLUMN population.subjectcount; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.population.subjectcount IS 'The total number of subjects in this population';


--
-- Name: COLUMN population.version; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.population.version IS 'The version number, iterates on modification';


--
-- Name: population_frequency_view; Type: VIEW; Schema: cpic; Owner: -
--

CREATE VIEW cpic.population_frequency_view AS
 WITH x AS (
         SELECT a.id AS alleleid,
            a.genesymbol,
            a.name,
            f.key AS population_group,
                CASE
                    WHEN (jsonb_typeof(f.value) = 'null'::text) THEN NULL::numeric
                    ELSE (f.value)::numeric
                END AS freq_weighted_avg
           FROM (cpic.allele a
             CROSS JOIN LATERAL jsonb_each(a.frequency) f(key, value))
        ), y AS (
         SELECT f.alleleid,
            p.ethnicity,
            max(f.frequency) AS freq_max,
            min(f.frequency) AS freq_min,
            avg(f.frequency) AS freq_avg,
            sum(p.subjectcount) AS subjectcount
           FROM (cpic.population p
             JOIN cpic.allele_frequency f ON ((p.id = f.population)))
          GROUP BY f.alleleid, p.ethnicity
        )
 SELECT x.genesymbol,
    x.name,
    x.population_group,
    y.subjectcount,
    x.freq_weighted_avg,
    y.freq_avg,
    y.freq_max,
    y.freq_min
   FROM (x
     JOIN y ON (((x.alleleid = y.alleleid) AND (x.population_group = y.ethnicity))));


--
-- Name: VIEW population_frequency_view; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON VIEW cpic.population_frequency_view IS 'A summary of frequency data by allele and major population group';


--
-- Name: COLUMN population_frequency_view.genesymbol; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.population_frequency_view.genesymbol IS 'The HGNC symbol of the gene';


--
-- Name: COLUMN population_frequency_view.name; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.population_frequency_view.name IS 'The allele name';


--
-- Name: COLUMN population_frequency_view.population_group; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.population_frequency_view.population_group IS 'The major grouping of population';


--
-- Name: COLUMN population_frequency_view.subjectcount; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.population_frequency_view.subjectcount IS 'The count of subjects assigned the population group for the given allele';


--
-- Name: COLUMN population_frequency_view.freq_weighted_avg; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.population_frequency_view.freq_weighted_avg IS 'The average frequency weighted by total subjects';


--
-- Name: COLUMN population_frequency_view.freq_avg; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.population_frequency_view.freq_avg IS 'The unweighted average frequency (use with caution)';


--
-- Name: COLUMN population_frequency_view.freq_max; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.population_frequency_view.freq_max IS 'The maximum frequency observed';


--
-- Name: COLUMN population_frequency_view.freq_min; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.population_frequency_view.freq_min IS 'The minimum frequency observed';


--
-- Name: publication; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.publication (
    id integer DEFAULT nextval('cpic.cpic_id'::regclass) NOT NULL,
    guidelineid integer,
    title text,
    authors text[],
    journal text,
    month integer,
    page character varying(50),
    volume character varying(50),
    year integer,
    pmid text,
    pmcid text,
    doi text,
    url text,
    version integer DEFAULT 1,
    highlightedonsite boolean DEFAULT false,
    fulltextfile text
);


--
-- Name: TABLE publication; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.publication IS 'Documents published to an external resource';


--
-- Name: COLUMN publication.id; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.publication.id IS 'A synthetic numerical ID, auto-assigned, primary key';


--
-- Name: COLUMN publication.guidelineid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.publication.guidelineid IS 'The ID for the guideline this publication is about, optional';


--
-- Name: COLUMN publication.pmid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.publication.pmid IS 'The PubMed identifier for this publication';


--
-- Name: COLUMN publication.pmcid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.publication.pmcid IS 'The PubMed Central identifier for this publication';


--
-- Name: COLUMN publication.doi; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.publication.doi IS 'The Document Object Identifier (DOI) for this publication';


--
-- Name: COLUMN publication.url; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.publication.url IS 'The URL for this publication';


--
-- Name: COLUMN publication.highlightedonsite; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.publication.highlightedonsite IS 'true means this publication will show in the CPIC site Publications page, defaults to false';


--
-- Name: COLUMN publication.fulltextfile; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.publication.fulltextfile IS 'publicly-accessible URL to full text of publication';


--
-- Name: publication_supplement; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.publication_supplement (
    id integer DEFAULT nextval('cpic.cpic_id'::regclass) NOT NULL,
    publicationid integer NOT NULL,
    description text,
    url text NOT NULL,
    version integer DEFAULT 1
);


--
-- Name: TABLE publication_supplement; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.publication_supplement IS 'A table to hold optional supplemental files for publications';


--
-- Name: COLUMN publication_supplement.id; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.publication_supplement.id IS 'A synthetic numerical ID, primary key';


--
-- Name: COLUMN publication_supplement.publicationid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.publication_supplement.publicationid IS 'A foreign-key reference to the publication this is a supplement for';


--
-- Name: COLUMN publication_supplement.description; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.publication_supplement.description IS 'An optional free text description of the supplemental file';


--
-- Name: COLUMN publication_supplement.url; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.publication_supplement.url IS 'The publicly-accessible URL to the supplemental file';


--
-- Name: COLUMN publication_supplement.version; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.publication_supplement.version IS 'The version number, iterates on modification';


--
-- Name: recommendation_alleles_view; Type: VIEW; Schema: cpic; Owner: -
--

CREATE VIEW cpic.recommendation_alleles_view AS
 SELECT a.genesymbol,
    g.chr,
    g.lookupmethod,
    array_agg(DISTINCT a.name ORDER BY a.name) AS alleles,
    count(DISTINCT a.name) AS allele_count
   FROM (cpic.allele a
     JOIN cpic.gene g ON (((a.genesymbol)::text = (g.symbol)::text)))
  WHERE ((a.clinicalfunctionalstatus IS NOT NULL) AND (g.lookupmethod <> 'ALLELE_STATUS'::text))
  GROUP BY a.genesymbol, g.chr, g.lookupmethod
UNION
 SELECT g.symbol AS genesymbol,
    g.chr,
    g.lookupmethod,
    array_agg(DISTINCT a.value ORDER BY a.value) AS alleles,
    count(DISTINCT a.value) AS allele_count
   FROM (cpic.recommendation r
     JOIN cpic.drug d ON (((r.drugid)::text = (d.drugid)::text))),
    (LATERAL jsonb_each_text(r.lookupkey) a(key, value)
     JOIN cpic.gene g ON ((a.key = (g.symbol)::text)))
  WHERE ((r.allelestatus IS NOT NULL) AND (g.lookupmethod = 'ALLELE_STATUS'::text) AND (upper(a.value) !~~ '%NO%RESULT%'::text))
  GROUP BY g.symbol, g.chr, g.lookupmethod;


--
-- Name: VIEW recommendation_alleles_view; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON VIEW cpic.recommendation_alleles_view IS 'A list of genes that are used for recommendation lookup and the alleles to use for those lookups';


--
-- Name: sequence_location; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.sequence_location (
    id integer DEFAULT nextval('cpic.cpic_id'::regclass) NOT NULL,
    version integer DEFAULT 1,
    name text,
    chromosomelocation text,
    genelocation text,
    proteinlocation text,
    genesymbol character varying(50) NOT NULL,
    dbsnpid text,
    "position" integer,
    CONSTRAINT chromosomelocation_nn CHECK ((chromosomelocation IS NOT NULL)),
    CONSTRAINT position_nn CHECK (("position" IS NOT NULL))
);


--
-- Name: TABLE sequence_location; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.sequence_location IS 'A location on a sequence';


--
-- Name: COLUMN sequence_location.name; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.sequence_location.name IS 'The short name of this sequence location, arbitrary but often the gene location and nucleotide change';


--
-- Name: COLUMN sequence_location.chromosomelocation; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.sequence_location.chromosomelocation IS 'The partial HGVS representation of the location on the chromosomal sequence';


--
-- Name: COLUMN sequence_location.genelocation; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.sequence_location.genelocation IS 'The partial HGVS representation of the location on the gene sequence';


--
-- Name: COLUMN sequence_location.proteinlocation; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.sequence_location.proteinlocation IS 'The partial HGVS representation of the location on the protein sequence';


--
-- Name: COLUMN sequence_location.genesymbol; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.sequence_location.genesymbol IS 'The HGNC symbol fo the gene this squence location falls in';


--
-- Name: COLUMN sequence_location.dbsnpid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.sequence_location.dbsnpid IS 'The DBSNP identifier (rs#) for this location, optional';


--
-- Name: COLUMN sequence_location."position"; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.sequence_location."position" IS 'The position, or starting position, of this variation on the chromosomal/mitochondrial sequence';


--
-- Name: statistic; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.statistic (
    createdon timestamp without time zone NOT NULL,
    stattype text NOT NULL,
    statvalue numeric NOT NULL
);


--
-- Name: TABLE statistic; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.statistic IS 'A collection of numerical statistics with metadata about this database and other CPIC data';


--
-- Name: term; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.term (
    id integer DEFAULT nextval('cpic.cpic_id'::regclass) NOT NULL,
    category text NOT NULL,
    term text NOT NULL,
    functionaldef text,
    geneticdef text,
    loinc text,
    version integer DEFAULT 1
);


--
-- Name: TABLE term; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.term IS 'Standardized terms for clinical PGx test results';


--
-- Name: COLUMN term.id; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.term.id IS 'A synthetic numerical ID, auto-assigned, primary key';


--
-- Name: COLUMN term.category; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.term.category IS 'Category group this term falls into';


--
-- Name: COLUMN term.term; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.term.term IS 'The term name';


--
-- Name: COLUMN term.functionaldef; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.term.functionaldef IS 'The functional definition of the term';


--
-- Name: COLUMN term.geneticdef; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.term.geneticdef IS 'The genetic definition of the term';


--
-- Name: COLUMN term.loinc; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.term.loinc IS 'The LOINC identifier for the term';




--
-- Data for Name: allele_definition; Type: TABLE DATA; Schema: cpic; Owner: -
--

COPY cpic.allele_definition (id, version, genesymbol, name, pharmvarid, matchesreferencesequence, structuralvariation) FROM stdin;
9000	1	HLA-A	*31:01	\N	f	f
9001	1	HLA-B	*15:02	\N	f	f
9002	1	HLA-B	*57:01	\N	f	f
9003	1	HLA-B	*58:01	\N	f	f
6355215	14	CFTR	A234D	\N	f	f
6355217	14	CFTR	A349V	\N	f	f
6355227	14	CFTR	D192G	\N	f	f
6355231	14	CFTR	D924N	\N	f	f
777333	104	CFTR	E56K	\N	f	f
6355241	14	CFTR	E822K	\N	f	f
6355245	14	CFTR	F311del	\N	f	f
6355247	14	CFTR	F311L	\N	f	f
6355257	14	CFTR	G178E	\N	f	f
6355263	14	CFTR	G194R(G>C)	\N	f	f
6355265	14	CFTR	G314E	\N	f	f
6355271	14	CFTR	G576A	\N	f	f
6355273	14	CFTR	G970D	\N	f	f
6355279	14	CFTR	G1249R(G>A)	\N	f	f
6355281	14	CFTR	G1249R(G>C)	\N	f	f
6355285	14	CFTR	H939R	\N	f	f
6355287	14	CFTR	H1375P	\N	f	f
6355289	14	CFTR	I148T	\N	f	f
6355293	14	CFTR	I807M	\N	f	f
6355295	14	CFTR	I1027T	\N	f	f
6355303	14	CFTR	L320V	\N	f	f
6355305	14	CFTR	L967S	\N	f	f
6355307	14	CFTR	L997F(G>C)	\N	f	f
6355309	14	CFTR	L997F(G>T)	\N	f	f
6355311	14	CFTR	L1480P	\N	f	f
6355313	14	CFTR	M152V	\N	f	f
6355315	14	CFTR	M952I(G>A)	\N	f	f
6355319	14	CFTR	M952I(G>T)	\N	f	f
6355321	14	CFTR	M952T	\N	f	f
777357	104	CFTR	P67L	\N	f	f
6355325	14	CFTR	Q237E	\N	f	f
6355327	14	CFTR	Q237H	\N	f	f
6355331	14	CFTR	Q1291R	\N	f	f
6355335	14	CFTR	R75Q	\N	f	f
6355339	14	CFTR	R117G	\N	f	f
6355343	14	CFTR	R117L	\N	f	f
6355345	14	CFTR	R117P	\N	f	f
6355347	14	CFTR	R170H	\N	f	f
6355351	14	CFTR	R347L	\N	f	f
6355355	14	CFTR	R553Q	\N	f	f
6355357	14	CFTR	R668C	\N	f	f
6355359	14	CFTR	R792G	\N	f	f
6355361	14	CFTR	R933G	\N	f	f
777432	186	CYP2B6	*6	\N	f	f
777434	186	CYP2B6	*7	\N	f	f
777436	186	CYP2B6	*8	\N	f	f
777438	186	CYP2B6	*9	\N	f	f
777440	186	CYP2B6	*10	\N	f	f
777442	186	CYP2B6	*11	\N	f	f
777444	186	CYP2B6	*12	\N	f	f
777448	186	CYP2B6	*14	\N	f	f
777450	186	CYP2B6	*15	\N	f	f
777452	186	CYP2B6	*17	\N	f	f
777454	186	CYP2B6	*18	\N	f	f
777456	186	CYP2B6	*19	\N	f	f
777460	186	CYP2B6	*21	\N	f	f
777462	186	CYP2B6	*22	\N	f	f
777464	186	CYP2B6	*23	\N	f	f
777466	186	CYP2B6	*24	\N	f	f
777468	186	CYP2B6	*25	\N	f	f
777470	186	CYP2B6	*26	\N	f	f
777474	186	CYP2B6	*28	\N	f	f
777476	181	CYP2B6	*29	\N	f	t
777478	181	CYP2B6	*30	\N	f	t
777480	186	CYP2B6	*31	\N	f	f
777482	186	CYP2B6	*32	\N	f	f
777484	186	CYP2B6	*33	\N	f	f
777486	186	CYP2B6	*34	\N	f	f
777490	186	CYP2B6	*36	\N	f	f
777492	186	CYP2B6	*37	\N	f	f
777494	186	CYP2B6	*38	\N	f	f
2899154	100	CYP2B6	*45	\N	f	f
2899156	100	CYP2B6	*46	\N	f	f
2899158	100	CYP2B6	*47	\N	f	f
2899162	100	CYP2B6	*49	\N	f	f
5997308	33	CYP2B6	*50	\N	f	f
777532	186	CYP2C19	*1	\N	f	f
777578	186	CYP2C19	*26	\N	f	f
777580	186	CYP2C19	*28	\N	f	f
777592	186	CYP2C19	*34	\N	f	f
6235065	29	CYP2C19	*41	\N	f	f
7721584	7	CYP2C19	*42	\N	f	t
777678	186	CYP2C9	*6	\N	f	f
777680	186	CYP2C9	*7	\N	f	f
777690	186	CYP2C9	*12	\N	f	f
777704	186	CYP2C9	*19	\N	f	f
777716	186	CYP2C9	*25	\N	f	f
777732	186	CYP2C9	*33	\N	f	f
777746	186	CYP2C9	*40	\N	f	f
777766	186	CYP2C9	*50	\N	f	f
777776	186	CYP2C9	*55	\N	f	f
777794	186	CYP2C9	*64	\N	f	f
1406321	156	CYP2C9	*75	\N	f	f
1933003	136	CYP2C9	*85	\N	f	f
777958	186	CYP2D6	*12	\N	f	f
778094	186	CYP2D6	*88	\N	f	f
778112	186	CYP2D6	*97	\N	f	f
778178	186	CYP2D6	*130	\N	f	f
778180	186	CYP2D6	*131	\N	f	f
778182	186	CYP2D6	*132	\N	f	f
778184	186	CYP2D6	*133	\N	f	f
778188	186	CYP2D6	*135	\N	f	f
778192	186	CYP2D6	*137	\N	f	f
778196	186	CYP2D6	*139	\N	f	f
778200	186	CYP2D6	*141	\N	f	f
778202	186	CYP2D6	*142	\N	f	f
778206	186	CYP2D6	*144	\N	f	f
778208	186	CYP2D6	*145	\N	f	f
1103379	168	CYP2D6	*147	\N	f	f
1609527	149	CYP2D6	*148	\N	f	f
1103381	168	CYP2D6	*149	\N	f	f
2677013	108	CYP2D6	*151	\N	f	f
2091236	130	CYP2D6	*152	\N	f	f
2091238	130	CYP2D6	*153	\N	f	f
2091244	130	CYP2D6	*156	\N	f	f
2091246	130	CYP2D6	*157	\N	f	f
5763832	37	CYP2D6	*177	\N	f	f
5998158	33	CYP2D6	*178	\N	f	f
2784576	104	CYP4F2	*6	\N	f	f
7094208	9	MT-RNR1	m.930G>A	\N	f	f
779315	179	SLCO1B1	*20	\N	f	f
779343	179	SLCO1B1	*34	\N	f	f
779347	179	SLCO1B1	*36	\N	f	f
6970385	19	SLCO1B1	*55	\N	f	f
6970387	19	SLCO1B1	*56	\N	f	f
6970389	19	SLCO1B1	*57	\N	f	f
6970391	19	SLCO1B1	*58	\N	f	f
6355395	14	CFTR	T1053I	\N	f	f
6355397	14	CFTR	V232D	\N	f	f
777552	186	CYP2C19	*11	\N	f	f
777576	186	CYP2C19	*25	\N	f	f
6235063	29	CYP2C19	*40	\N	f	f
777682	186	CYP2C9	*8	\N	f	f
777758	186	CYP2C9	*46	\N	f	f
6235320	29	CYP2C9	*86	\N	f	f
6235322	29	CYP2C9	*87	\N	f	f
6235324	29	CYP2C9	*88	\N	f	f
777946	186	CYP2D6	*6	\N	f	f
777948	186	CYP2D6	*7	\N	f	f
777950	186	CYP2D6	*8	\N	f	f
777952	186	CYP2D6	*9	\N	f	f
777970	186	CYP2D6	*19	\N	f	f
777978	186	CYP2D6	*23	\N	f	f
777988	186	CYP2D6	*28	\N	f	f
778014	186	CYP2D6	*41	\N	f	f
778016	186	CYP2D6	*42	\N	f	f
778018	186	CYP2D6	*43	\N	f	f
778020	186	CYP2D6	*44	\N	f	f
778022	186	CYP2D6	*45	\N	f	f
778024	186	CYP2D6	*46	\N	f	f
778026	186	CYP2D6	*47	\N	f	f
778028	186	CYP2D6	*48	\N	f	f
778030	186	CYP2D6	*49	\N	f	f
778032	186	CYP2D6	*50	\N	f	f
778034	186	CYP2D6	*51	\N	f	f
778036	186	CYP2D6	*52	\N	f	f
778038	186	CYP2D6	*53	\N	f	f
778040	186	CYP2D6	*54	\N	f	f
778042	186	CYP2D6	*55	\N	f	f
778044	186	CYP2D6	*56	\N	f	f
778048	186	CYP2D6	*58	\N	f	f
778050	186	CYP2D6	*59	\N	f	f
778052	186	CYP2D6	*60	\N	f	f
778054	181	CYP2D6	*61	\N	f	t
778056	186	CYP2D6	*62	\N	f	f
778058	181	CYP2D6	*63	\N	f	t
778060	186	CYP2D6	*64	\N	f	f
778062	186	CYP2D6	*65	\N	f	f
778064	181	CYP2D6	*68	\N	f	t
778066	186	CYP2D6	*69	\N	f	f
778068	186	CYP2D6	*70	\N	f	f
778070	186	CYP2D6	*71	\N	f	f
778072	186	CYP2D6	*72	\N	f	f
778074	186	CYP2D6	*73	\N	f	f
778076	186	CYP2D6	*74	\N	f	f
778078	186	CYP2D6	*75	\N	f	f
778080	186	CYP2D6	*81	\N	f	f
778082	186	CYP2D6	*82	\N	f	f
778084	186	CYP2D6	*83	\N	f	f
778086	186	CYP2D6	*84	\N	f	f
778088	186	CYP2D6	*85	\N	f	f
778090	186	CYP2D6	*86	\N	f	f
778092	186	CYP2D6	*87	\N	f	f
778096	186	CYP2D6	*89	\N	f	f
778108	186	CYP2D6	*95	\N	f	f
778114	186	CYP2D6	*98	\N	f	f
778186	186	CYP2D6	*134	\N	f	f
778204	186	CYP2D6	*143	\N	f	f
2677011	108	CYP2D6	*150	\N	f	f
2091250	130	CYP2D6	*159	\N	f	f
2091252	130	CYP2D6	*160	\N	f	f
2091254	130	CYP2D6	*161	\N	f	f
2091256	130	CYP2D6	*162	\N	f	f
2091258	130	CYP2D6	*163	\N	f	f
2677039	108	CYP2D6	*164	\N	f	f
2677043	108	CYP2D6	*166	\N	f	f
2677045	108	CYP2D6	*167	\N	f	f
2677047	108	CYP2D6	*168	\N	f	f
2677049	108	CYP2D6	*169	\N	f	f
2677051	108	CYP2D6	*170	\N	f	f
2677053	108	CYP2D6	*171	\N	f	f
3318539	85	CYP2D6	*172	\N	f	f
5175550	47	CYP2D6	*173	\N	f	f
5175552	47	CYP2D6	*174	\N	f	f
5175554	47	CYP2D6	*175	\N	f	f
5409119	43	CYP2D6	*176	\N	f	f
5998160	33	CYP2D6	*179	\N	f	f
5998162	33	CYP2D6	*180	\N	f	f
5998164	33	CYP2D6	*181	\N	f	f
5998166	33	CYP2D6	*182	\N	f	f
5998168	33	CYP2D6	*183	\N	f	f
5998170	33	CYP2D6	*184	\N	f	f
5998172	33	CYP2D6	*185	\N	f	f
778240	185	CYP4F2	*2	\N	f	f
778242	185	CYP4F2	*3	\N	f	f
2784572	104	CYP4F2	*4	\N	f	f
2784578	104	CYP4F2	*7	\N	f	f
3318585	85	CYP4F2	*8	\N	f	f
3318587	85	CYP4F2	*9	\N	f	f
3318593	85	CYP4F2	*12	\N	f	f
3318595	85	CYP4F2	*13	\N	f	f
3318599	85	CYP4F2	*15	\N	f	f
3318601	85	CYP4F2	*16	\N	f	t
4058604	62	CYP4F2	*17	\N	f	f
778337	104	DPYD	c.295_298delTCAT (*7)	\N	f	f
778780	106	G6PD	Taipei, Chinese-3	\N	f	f
778872	104	G6PD	West Virginia	\N	f	f
779080	185	NUDT15	*9	\N	f	f
3685882	43	RYR1	c.13913G>A	\N	f	f
3685898	43	RYR1	c.14168G>A	\N	f	f
3685900	43	RYR1	c.14186A>C	\N	f	f
3685902	43	RYR1	c.14197T>G	\N	f	f
3685910	43	RYR1	c.14270G>A	\N	f	f
779232	104	RYR1	c.14387A>G	\N	f	f
3685924	43	RYR1	c.14471T>C	\N	f	f
779234	104	RYR1	c.14477C>T	\N	f	f
779236	104	RYR1	c.14497C>T	\N	f	f
3685936	43	RYR1	c.14524G>A	\N	f	f
3685938	43	RYR1	c.14539G>C	\N	f	f
3685948	43	RYR1	c.14581C>T	\N	f	f
3685960	43	RYR1	c.14782A>G	\N	f	f
3685972	43	RYR1	c.14825G>T	\N	f	f
779283	179	SLCO1B1	*4	\N	f	f
779285	179	SLCO1B1	*5	\N	f	f
779297	179	SLCO1B1	*11	\N	f	f
779303	179	SLCO1B1	*14	\N	f	f
779305	179	SLCO1B1	*15	\N	f	f
779307	179	SLCO1B1	*16	\N	f	f
779321	179	SLCO1B1	*23	\N	f	f
779323	179	SLCO1B1	*24	\N	f	f
779325	179	SLCO1B1	*25	\N	f	f
779327	179	SLCO1B1	*26	\N	f	f
779331	179	SLCO1B1	*28	\N	f	f
779333	179	SLCO1B1	*29	\N	f	f
779335	179	SLCO1B1	*30	\N	f	f
779337	179	SLCO1B1	*31	\N	f	f
779339	179	SLCO1B1	*32	\N	f	f
1002693	170	SLCO1B1	*41	\N	f	f
1002695	170	SLCO1B1	*42	\N	f	f
1002697	170	SLCO1B1	*43	\N	f	f
1002701	170	SLCO1B1	*45	\N	f	f
1357091	158	SLCO1B1	*48	\N	f	t
6355377	14	CFTR	S589N	\N	f	f
6355379	14	CFTR	S737F	\N	f	f
6355385	14	CFTR	S1159F	\N	f	f
6355393	14	CFTR	T338I	\N	f	f
6355399	14	CFTR	V562I	\N	f	f
6355401	14	CFTR	V754M	\N	f	f
6355403	14	CFTR	V1293G	\N	f	f
6355405	14	CFTR	W1282R	\N	f	f
6355407	14	CFTR	Y1014C	\N	f	f
6355409	14	CFTR	Y1032C	\N	f	f
777428	186	CYP2B6	*4	\N	f	f
777534	186	CYP2C19	*2	\N	f	f
777536	186	CYP2C19	*3	\N	f	f
777538	186	CYP2C19	*4	\N	f	f
777540	186	CYP2C19	*5	\N	f	f
777542	186	CYP2C19	*6	\N	f	f
777544	186	CYP2C19	*7	\N	f	f
777548	186	CYP2C19	*9	\N	f	f
777550	186	CYP2C19	*10	\N	f	f
777554	186	CYP2C19	*12	\N	f	f
777556	186	CYP2C19	*13	\N	f	f
777558	186	CYP2C19	*14	\N	f	f
777560	186	CYP2C19	*15	\N	f	f
777562	186	CYP2C19	*16	\N	f	f
777564	186	CYP2C19	*17	\N	f	f
777566	186	CYP2C19	*18	\N	f	f
777568	186	CYP2C19	*19	\N	f	f
777570	186	CYP2C19	*22	\N	f	f
777572	186	CYP2C19	*23	\N	f	f
777574	186	CYP2C19	*24	\N	f	f
777594	186	CYP2C19	*35	\N	f	f
777598	181	CYP2C19	*37	\N	f	t
777600	186	CYP2C19	*39	\N	f	f
777684	186	CYP2C9	*9	\N	f	f
777686	186	CYP2C9	*10	\N	f	f
777692	186	CYP2C9	*13	\N	f	f
777694	186	CYP2C9	*14	\N	f	f
777770	186	CYP2C9	*52	\N	f	f
777772	186	CYP2C9	*53	\N	f	f
777774	186	CYP2C9	*54	\N	f	f
777778	186	CYP2C9	*56	\N	f	f
777780	186	CYP2C9	*57	\N	f	f
777782	186	CYP2C9	*58	\N	f	f
777784	186	CYP2C9	*59	\N	f	f
777786	186	CYP2C9	*60	\N	f	f
777788	186	CYP2C9	*61	\N	f	f
777790	186	CYP2C9	*62	\N	f	f
777792	186	CYP2C9	*63	\N	f	f
777796	186	CYP2C9	*65	\N	f	f
777798	186	CYP2C9	*66	\N	f	f
777800	186	CYP2C9	*67	\N	f	f
777802	186	CYP2C9	*68	\N	f	f
777944	181	CYP2D6	*5	\N	f	t
777994	186	CYP2D6	*31	\N	f	f
778116	186	CYP2D6	*99	\N	f	f
778190	186	CYP2D6	*136	\N	f	f
1103377	168	CYP2D6	*146	\N	f	f
2091242	130	CYP2D6	*155	\N	f	f
6235905	29	CYP4F2	*18	\N	f	f
6235907	29	CYP4F2	*19	\N	f	f
6235909	29	CYP4F2	*20	\N	f	f
6235911	29	CYP4F2	*21	\N	f	f
6235913	29	CYP4F2	*22	\N	f	f
778435	104	DPYD	c.1905C>G	\N	f	f
778453	104	DPYD	c.2279C>T	\N	f	f
778483	104	DPYD	c.2977C>T	\N	f	f
778485	104	DPYD	c.2983G>T (*10)	\N	f	f
778714	104	G6PD	202G>A_376A>G_1264C>G	\N	f	f
778752	104	G6PD	A	\N	f	f
778712	104	G6PD	A- 202A_376G	\N	f	f
778742	104	G6PD	Acrokorinthos	\N	f	f
779002	104	G6PD	Andalus	\N	f	f
778826	104	G6PD	Asahikawa	\N	f	f
778938	104	G6PD	Beverly Hills, Genova, Iwate, Niigata, Yamaguchi	\N	f	f
779038	104	G6PD	Brighton	\N	f	f
778774	104	G6PD	Gond	\N	f	f
778906	104	G6PD	Ierapetra	\N	f	f
778724	104	G6PD	Lagosanto	\N	f	f
778954	104	G6PD	Puerto Limon	\N	f	f
778990	104	G6PD	Santiago de Cuba, Morioka	\N	f	f
779041	104	IFNL3	rs12979860 reference (C)	\N	t	f
779043	104	IFNL3	rs12979860 variant (T)	\N	f	f
7096542	17	NAT2	*65	\N	f	f
7096544	17	NAT2	*66	\N	f	f
7096546	17	NAT2	*67	\N	f	f
7096548	17	NAT2	*68	\N	f	f
7096550	17	NAT2	*69	\N	f	f
3685874	43	RYR1	c.13673G>A	\N	f	f
3685876	43	RYR1	c.13672C>T	\N	f	f
3685878	43	RYR1	c.13702C>G	\N	f	f
3685880	43	RYR1	c.13760C>T	\N	f	f
3685886	43	RYR1	c.13934G>A	\N	f	f
3685888	43	RYR1	c.13990T>C	\N	f	f
3685890	43	RYR1	c.13994_13995delTCinsCT	\N	f	f
3685892	43	RYR1	c.14002C>T	\N	f	f
3685894	43	RYR1	c.14051T>C	\N	f	f
3685896	43	RYR1	c.14126C>T	\N	f	f
3685904	43	RYR1	c.14201G>A	\N	f	f
3685906	43	RYR1	c.14209C>T	\N	f	f
3685908	43	RYR1	c.14210G>A	\N	f	f
3685916	43	RYR1	c.14424C>A	\N	f	f
3685918	43	RYR1	c.14449A>T	\N	f	f
3685920	43	RYR1	c.14458G>A	\N	f	f
3685922	43	RYR1	c.14458G>T	\N	f	f
3685930	43	RYR1	c.14510delA	\N	f	f
3685932	43	RYR1	c.14509C>G	\N	f	f
779238	104	RYR1	c.14512C>G	\N	f	f
779240	104	RYR1	c.14545G>A	\N	f	f
3685942	43	RYR1	c.14558C>T	\N	f	f
3685944	43	RYR1	c.14567C>G	\N	f	f
779242	104	RYR1	c.14582G>A	\N	f	f
3685950	43	RYR1	c.14627A>G	\N	f	f
3685952	43	RYR1	c.14639T>C	\N	f	f
3685954	43	RYR1	c.14678G>A	\N	f	f
3685956	43	RYR1	c.14680G>A	\N	f	f
779244	104	RYR1	c.14693T>C	\N	f	f
3685962	43	RYR1	c.14803G>A	\N	f	f
3685964	43	RYR1	c.14813T>C	\N	f	f
3685966	43	RYR1	c.14814C>G	\N	f	f
3685968	43	RYR1	c.14817C>A	\N	f	f
3685970	43	RYR1	c.14818G>A	\N	f	f
3685974	43	RYR1	c.14879T>A	\N	f	f
3685976	43	RYR1	c.14918C>T	\N	f	f
3685978	43	RYR1	c.14968A>G	\N	f	f
3685980	43	RYR1	c.15059G>C	\N	f	f
1002623	170	SLCO1B1	*1	\N	t	f
779279	179	SLCO1B1	*2	\N	f	f
779287	179	SLCO1B1	*6	\N	f	f
779291	179	SLCO1B1	*8	\N	f	f
779293	179	SLCO1B1	*9	\N	f	f
1002685	170	SLCO1B1	*37	\N	f	f
1357093	158	SLCO1B1	*49	\N	f	t
7726082	4	TPMT	*45	\N	f	f
7726084	4	TPMT	*46	\N	f	f
7726086	4	TPMT	*47	\N	f	f
777339	104	CFTR	F1074L	\N	f	f
6355261	14	CFTR	G194R(G>A)	\N	f	f
6355291	14	CFTR	I175V	\N	f	f
6355317	14	CFTR	M952I(G>C)	\N	f	f
777379	104	CFTR	S549R(A>C)	\N	f	f
777430	186	CYP2B6	*5	\N	f	f
777446	186	CYP2B6	*13	\N	f	f
777472	186	CYP2B6	*27	\N	f	f
2899142	100	CYP2B6	*39	\N	f	f
2899146	100	CYP2B6	*41	\N	f	f
2899148	100	CYP2B6	*42	\N	f	f
2899150	100	CYP2B6	*43	\N	f	f
2899152	100	CYP2B6	*44	\N	f	f
777530	186	CYP2C19	*38	\N	t	f
777670	186	CYP2C9	*2	\N	f	f
777672	186	CYP2C9	*3	\N	f	f
777676	186	CYP2C9	*5	\N	f	f
777696	186	CYP2C9	*15	\N	f	f
777698	186	CYP2C9	*16	\N	f	f
777700	186	CYP2C9	*17	\N	f	f
777702	186	CYP2C9	*18	\N	f	f
777706	186	CYP2C9	*20	\N	f	f
777710	186	CYP2C9	*22	\N	f	f
777712	186	CYP2C9	*23	\N	f	f
777714	186	CYP2C9	*24	\N	f	f
777720	186	CYP2C9	*27	\N	f	f
777722	186	CYP2C9	*28	\N	f	f
777724	186	CYP2C9	*29	\N	f	f
777726	186	CYP2C9	*30	\N	f	f
777728	186	CYP2C9	*31	\N	f	f
777730	186	CYP2C9	*32	\N	f	f
777734	186	CYP2C9	*34	\N	f	f
777738	186	CYP2C9	*36	\N	f	f
777740	186	CYP2C9	*37	\N	f	f
777742	186	CYP2C9	*38	\N	f	f
777744	186	CYP2C9	*39	\N	f	f
777748	186	CYP2C9	*41	\N	f	f
777750	186	CYP2C9	*42	\N	f	f
777752	186	CYP2C9	*43	\N	f	f
777756	186	CYP2C9	*45	\N	f	f
777760	186	CYP2C9	*47	\N	f	f
777762	186	CYP2C9	*48	\N	f	f
777764	186	CYP2C9	*49	\N	f	f
777768	186	CYP2C9	*51	\N	f	f
777804	186	CYP2C9	*69	\N	f	f
777806	186	CYP2C9	*70	\N	f	f
1406315	156	CYP2C9	*72	\N	f	f
1406317	156	CYP2C9	*73	\N	f	f
1406319	156	CYP2C9	*74	\N	f	f
1932985	136	CYP2C9	*76	\N	f	f
1932987	136	CYP2C9	*77	\N	f	f
1932989	136	CYP2C9	*78	\N	f	f
1932991	136	CYP2C9	*79	\N	f	f
1932993	136	CYP2C9	*80	\N	f	f
1932997	136	CYP2C9	*82	\N	f	f
1932999	136	CYP2C9	*83	\N	f	f
1933001	136	CYP2C9	*84	\N	f	f
777936	186	CYP2D6	*1	\N	t	f
777938	186	CYP2D6	*2	\N	f	f
777940	186	CYP2D6	*3	\N	f	f
777942	186	CYP2D6	*4	\N	f	f
777954	186	CYP2D6	*10	\N	f	f
777956	186	CYP2D6	*11	\N	f	f
777962	186	CYP2D6	*14	\N	f	f
777964	186	CYP2D6	*15	\N	f	f
777966	186	CYP2D6	*17	\N	f	f
777968	186	CYP2D6	*18	\N	f	f
777972	186	CYP2D6	*20	\N	f	f
777974	186	CYP2D6	*21	\N	f	f
777976	186	CYP2D6	*22	\N	f	f
777980	186	CYP2D6	*24	\N	f	f
777982	186	CYP2D6	*25	\N	f	f
777984	186	CYP2D6	*26	\N	f	f
777986	186	CYP2D6	*27	\N	f	f
777990	186	CYP2D6	*29	\N	f	f
777992	186	CYP2D6	*30	\N	f	f
777996	186	CYP2D6	*32	\N	f	f
777998	186	CYP2D6	*33	\N	f	f
778000	186	CYP2D6	*34	\N	f	f
778002	186	CYP2D6	*35	\N	f	f
778004	186	CYP2D6	*36	\N	f	f
778006	186	CYP2D6	*37	\N	f	f
778008	186	CYP2D6	*38	\N	f	f
778010	186	CYP2D6	*39	\N	f	f
778012	186	CYP2D6	*40	\N	f	f
778098	186	CYP2D6	*90	\N	f	f
778118	186	CYP2D6	*100	\N	f	f
778120	186	CYP2D6	*101	\N	f	f
778122	186	CYP2D6	*102	\N	f	f
778124	186	CYP2D6	*103	\N	f	f
778126	186	CYP2D6	*104	\N	f	f
778128	186	CYP2D6	*105	\N	f	f
778130	186	CYP2D6	*106	\N	f	f
778132	186	CYP2D6	*107	\N	f	f
778136	186	CYP2D6	*109	\N	f	f
778138	186	CYP2D6	*110	\N	f	f
778140	186	CYP2D6	*111	\N	f	f
778142	186	CYP2D6	*112	\N	f	f
778144	186	CYP2D6	*113	\N	f	f
778164	186	CYP2D6	*123	\N	f	f
778170	186	CYP2D6	*126	\N	f	f
3318597	85	CYP4F2	*14	\N	f	f
6235915	29	CYP4F2	*23	\N	f	f
778800	105	G6PD	Mediterranean, Dallas, Panama, Sassari, Cagliari, Birmingham	\N	f	f
778802	104	G6PD	Pedoplis-Ckaro	\N	f	f
778744	104	G6PD	Santa Maria	\N	f	f
828095	103	MT-RNR1	Reference	\N	t	f
6481190	25	NAT2	*1	\N	t	f
6481192	25	NAT2	*4	\N	f	f
6481218	25	NAT2	*31	\N	f	f
6481220	25	NAT2	*32	\N	f	f
6481228	25	NAT2	*36	\N	f	f
6481230	25	NAT2	*37	\N	f	f
6481256	25	NAT2	*50	\N	f	f
6481262	25	NAT2	*53	\N	f	f
6481272	25	NAT2	*58	\N	f	f
7219570	15	NAT2	*70	\N	f	f
7219572	15	NAT2	*71	\N	f	f
7219574	15	NAT2	*72	\N	f	f
7219576	15	NAT2	*73	\N	f	f
7219578	15	NAT2	*74	\N	f	f
7219580	15	NAT2	*75	\N	f	f
3685694	43	RYR1	c.7771C>T	\N	f	f
3685726	43	RYR1	c.8518C>T	\N	f	f
3685758	43	RYR1	c.9758T>C	\N	f	f
3685790	43	RYR1	c.10891G>T	\N	f	f
3685822	43	RYR1	c.11953T>C	\N	f	f
3685856	43	RYR1	c.12553G>A	\N	f	f
1002689	170	SLCO1B1	*39	\N	f	f
6237969	29	SLCO1B1	*50	\N	f	f
6237971	29	SLCO1B1	*51	\N	f	f
6237973	29	SLCO1B1	*52	\N	f	f
6237975	29	SLCO1B1	*53	\N	f	f
6237977	29	SLCO1B1	*54	\N	f	f
777458	186	CYP2B6	*20	\N	f	f
777488	186	CYP2B6	*35	\N	f	f
777546	186	CYP2C19	*8	\N	f	f
777674	186	CYP2C9	*4	\N	f	f
777688	186	CYP2C9	*11	\N	f	f
778146	186	CYP2D6	*114	\N	f	f
778148	186	CYP2D6	*115	\N	f	f
778150	186	CYP2D6	*116	\N	f	f
778152	186	CYP2D6	*117	\N	f	f
778156	186	CYP2D6	*119	\N	f	f
778162	186	CYP2D6	*122	\N	f	f
778166	186	CYP2D6	*124	\N	f	f
778168	186	CYP2D6	*125	\N	f	f
778172	186	CYP2D6	*127	\N	f	f
778176	186	CYP2D6	*129	\N	f	f
778218	186	CYP3A5	*1	\N	t	f
778222	186	CYP3A5	*3	\N	f	f
778230	186	CYP3A5	*7	\N	f	f
778232	186	CYP3A5	*8	\N	f	f
778234	186	CYP3A5	*9	\N	f	f
2784574	104	CYP4F2	*5	\N	f	f
3827872	37	MT-RNR1	m.663A>G	\N	f	f
3827874	37	MT-RNR1	m.669T>C	\N	f	f
3827876	37	MT-RNR1	m.747A>G	\N	f	f
3827878	37	MT-RNR1	m.786G>A	\N	f	f
3827880	37	MT-RNR1	m.807A>C	\N	f	f
3827882	37	MT-RNR1	m.807A>G	\N	f	f
3827884	37	MT-RNR1	m.827A>G	\N	f	f
3827886	37	MT-RNR1	m.839A>G	\N	f	f
3827888	37	MT-RNR1	m.896A>G	\N	f	f
3827892	37	MT-RNR1	m.951G>A	\N	f	f
3827894	37	MT-RNR1	m.960C>del	\N	f	f
3827896	37	MT-RNR1	m.961T>G	\N	f	f
3827898	37	MT-RNR1	m.961T>del	\N	f	f
3827900	37	MT-RNR1	m.961T>del+Cn	\N	f	f
3827902	37	MT-RNR1	m.988G>A	\N	f	f
3827904	37	MT-RNR1	m.1095T>C	\N	f	f
3827906	37	MT-RNR1	m.1189T>C	\N	f	f
3827908	37	MT-RNR1	m.1243T>C	\N	f	f
3827910	37	MT-RNR1	m.1494C>T	\N	f	f
3827912	37	MT-RNR1	m.1520T>C	\N	f	f
3827914	37	MT-RNR1	m.1537C>T	\N	f	f
3827916	37	MT-RNR1	m.1555A>G	\N	f	f
3827918	37	MT-RNR1	m.1556C>T	\N	f	f
6481194	25	NAT2	*5	\N	f	f
6481196	25	NAT2	*6	\N	f	f
6481198	25	NAT2	*7	\N	f	f
6481200	25	NAT2	*10	\N	f	f
6481204	25	NAT2	*15	\N	f	f
6481206	25	NAT2	*16	\N	f	f
6481208	25	NAT2	*19	\N	f	f
6481210	25	NAT2	*21	\N	f	f
6481212	25	NAT2	*27	\N	f	f
6481216	25	NAT2	*30	\N	f	f
6481222	25	NAT2	*33	\N	f	f
6481226	25	NAT2	*35	\N	f	f
6481232	25	NAT2	*38	\N	f	f
6481236	25	NAT2	*40	\N	f	f
6481238	25	NAT2	*41	\N	f	f
6481240	25	NAT2	*42	\N	f	f
6481244	25	NAT2	*44	\N	f	f
6481246	25	NAT2	*45	\N	f	f
6481248	25	NAT2	*46	\N	f	f
6481250	25	NAT2	*47	\N	f	f
6481254	25	NAT2	*49	\N	f	f
6481258	25	NAT2	*51	\N	f	f
6481264	25	NAT2	*54	\N	f	f
6481266	25	NAT2	*55	\N	f	f
6481268	25	NAT2	*56	\N	f	f
6481274	25	NAT2	*59	\N	f	f
6481276	25	NAT2	*60	\N	f	f
6481280	25	NAT2	*62	\N	f	f
6481282	25	NAT2	*63	\N	f	f
6481284	25	NAT2	*64	\N	f	f
779064	185	NUDT15	*1	\N	t	f
779068	185	NUDT15	*3	\N	f	f
779070	185	NUDT15	*4	\N	f	f
779072	185	NUDT15	*5	\N	f	f
779074	185	NUDT15	*6	\N	f	f
779076	185	NUDT15	*7	\N	f	f
779078	185	NUDT15	*8	\N	f	f
779082	185	NUDT15	*10	\N	f	f
779084	185	NUDT15	*11	\N	f	f
779086	185	NUDT15	*12	\N	f	f
779088	185	NUDT15	*13	\N	f	f
779090	185	NUDT15	*14	\N	f	f
779092	185	NUDT15	*15	\N	f	f
779094	185	NUDT15	*16	\N	f	f
779096	185	NUDT15	*17	\N	f	f
779098	185	NUDT15	*18	\N	f	f
779100	185	NUDT15	*19	\N	f	f
779102	185	NUDT15	*20	\N	f	f
5881976	35	NUDT15	*21	\N	f	f
779313	179	SLCO1B1	*19	\N	f	f
779329	179	SLCO1B1	*27	\N	f	f
779341	179	SLCO1B1	*33	\N	f	f
1002691	170	SLCO1B1	*40	\N	f	f
1002699	170	SLCO1B1	*44	\N	f	f
1002705	170	SLCO1B1	*47	\N	f	f
779392	104	TPMT	*1	\N	t	f
779394	104	TPMT	*2	\N	f	f
779396	104	TPMT	*3A	\N	f	f
779398	104	TPMT	*3B	\N	f	f
779400	104	TPMT	*3C	\N	f	f
779402	104	TPMT	*4	\N	f	f
779404	104	TPMT	*5	\N	f	f
779406	104	TPMT	*6	\N	f	f
779408	104	TPMT	*7	\N	f	f
779410	104	TPMT	*8	\N	f	f
779412	104	TPMT	*9	\N	f	f
779414	104	TPMT	*10	\N	f	f
779416	104	TPMT	*11	\N	f	f
779418	104	TPMT	*12	\N	f	f
779420	104	TPMT	*13	\N	f	f
779422	104	TPMT	*14	\N	f	f
779424	104	TPMT	*15	\N	f	f
779426	104	TPMT	*16	\N	f	f
779428	104	TPMT	*17	\N	f	f
779430	104	TPMT	*18	\N	f	f
779432	104	TPMT	*19	\N	f	f
779434	104	TPMT	*20	\N	f	f
779436	104	TPMT	*21	\N	f	f
779438	104	TPMT	*22	\N	f	f
779440	104	TPMT	*23	\N	f	f
779442	104	TPMT	*24	\N	f	f
779444	104	TPMT	*25	\N	f	f
779446	104	TPMT	*26	\N	f	f
779448	104	TPMT	*27	\N	f	f
779450	104	TPMT	*28	\N	f	f
779452	104	TPMT	*29	\N	f	f
779454	104	TPMT	*30	\N	f	f
779456	104	TPMT	*31	\N	f	f
779458	104	TPMT	*32	\N	f	f
779460	104	TPMT	*33	\N	f	f
779462	104	TPMT	*34	\N	f	f
779464	104	TPMT	*35	\N	f	f
779466	104	TPMT	*36	\N	f	f
779468	104	TPMT	*37	\N	f	f
779470	104	TPMT	*38	\N	f	f
779472	104	TPMT	*39	\N	f	f
778228	186	CYP3A5	*6	\N	f	f
3318589	85	CYP4F2	*10	\N	f	f
3685332	43	RYR1	c.251C>T	\N	f	f
3685334	43	RYR1	c.418G>A	\N	f	f
3685336	43	RYR1	c.455C>A	\N	f	f
3685338	43	RYR1	c.463C>A	\N	f	f
3685340	43	RYR1	c.467G>A	\N	f	f
3685342	43	RYR1	c.479A>G	\N	f	f
779154	104	RYR1	c.487C>T	\N	f	f
779156	104	RYR1	c.488G>T	\N	f	f
3685348	43	RYR1	c.488G>A	\N	f	f
3685350	43	RYR1	c.493G>A	\N	f	f
3685352	43	RYR1	c.496G>A	\N	f	f
3685354	43	RYR1	c.497A>G	\N	f	f
3685356	43	RYR1	c.526G>A	\N	f	f
3685358	43	RYR1	c.528G>T	\N	f	f
3685362	43	RYR1	c.533A>G	\N	f	f
3685364	43	RYR1	c.533A>C	\N	f	f
3685368	43	RYR1	c.641C>T	\N	f	f
3685370	43	RYR1	c.652G>A	\N	f	f
3685372	43	RYR1	c.677T>A	\N	f	f
3685374	43	RYR1	c.680A>T	\N	f	f
779160	104	RYR1	c.742G>A	\N	f	f
779158	104	RYR1	c.742G>C	\N	f	f
3685380	43	RYR1	c.946C>T	\N	f	f
3685382	43	RYR1	c.947G>T	\N	f	f
779162	104	RYR1	c.982C>T	\N	f	f
779164	104	RYR1	c.1021G>A	\N	f	f
779166	104	RYR1	c.1021G>C	\N	f	f
3685392	43	RYR1	c.1024G>A	\N	f	f
3685394	43	RYR1	c.1100G>A	\N	f	f
3685396	43	RYR1	c.1100G>T	\N	f	f
3685398	43	RYR1	c.1144C>A	\N	f	f
779168	104	RYR1	c.1201C>T	\N	f	f
3685402	43	RYR1	c.1201C>A	\N	f	f
3685404	43	RYR1	c.1201C>G	\N	f	f
3685406	43	RYR1	c.1202G>T	\N	f	f
3685408	43	RYR1	c.1202G>A	\N	f	f
779170	104	RYR1	c.1209C>G	\N	f	f
3685412	43	RYR1	c.1411C>T	\N	f	f
3685416	43	RYR1	c.1453A>G	\N	f	f
3685418	43	RYR1	c.1459C>G	\N	f	f
3685420	43	RYR1	c.1460T>C	\N	f	f
3685422	43	RYR1	c.1475G>A	\N	f	f
3685424	43	RYR1	c.1553T>C	\N	f	f
779172	104	RYR1	c.1565A>C	\N	f	f
3685428	43	RYR1	c.1565A>G	\N	f	f
779174	104	RYR1	c.1589G>A	\N	f	f
779176	104	RYR1	c.1597C>T	\N	f	f
3685434	43	RYR1	c.1597C>A	\N	f	f
779178	104	RYR1	c.1598G>A	\N	f	f
3685438	43	RYR1	c.1615T>C	\N	f	f
3685440	43	RYR1	c.1615T>G	\N	f	f
3685442	43	RYR1	c.1630G>T	\N	f	f
3685446	43	RYR1	c.1834G>C	\N	f	f
779182	104	RYR1	c.1840C>T	\N	f	f
779184	104	RYR1	c.1841G>T	\N	f	f
3685452	43	RYR1	c.2050G>C	\N	f	f
3685454	43	RYR1	c.2122G>A	\N	f	f
3685456	43	RYR1	c.2447C>T	\N	f	f
3685458	43	RYR1	c.2537C>T	\N	f	f
3685460	43	RYR1	c.2654G>A	\N	f	f
3685462	43	RYR1	c.2797G>A	\N	f	f
3685464	43	RYR1	c.2924G>A	\N	f	f
3685466	43	RYR1	c.2996G>A	\N	f	f
3685468	43	RYR1	c.3095G>A	\N	f	f
3685470	43	RYR1	c.3127C>T	\N	f	f
3685472	43	RYR1	c.3166G>C	\N	f	f
3685476	43	RYR1	c.3172G>A	\N	f	f
3685478	43	RYR1	c.3224G>A	\N	f	f
3685480	43	RYR1	c.3418C>T	\N	f	f
3685482	43	RYR1	c.3527C>T	\N	f	f
3685484	43	RYR1	c.3656A>C	\N	f	f
3685486	43	RYR1	c.3667G>A	\N	f	f
3685488	43	RYR1	c.4024A>G	\N	f	f
3685490	43	RYR1	c.4178A>G	\N	f	f
3685492	43	RYR1	c.4400A>G	\N	f	f
3685494	43	RYR1	c.4711A>G	\N	f	f
3685496	43	RYR1	c.4747C>T	\N	f	f
3685498	43	RYR1	c.4763C>T	\N	f	f
3685500	43	RYR1	c.4775C>T	\N	f	f
3685502	43	RYR1	c.5024T>C	\N	f	f
3685506	43	RYR1	c.5036G>A	\N	f	f
3685508	43	RYR1	c.5132A>G	\N	f	f
3685510	43	RYR1	c.5183C>T	\N	f	f
3685512	43	RYR1	c.5186T>G	\N	f	f
3685514	43	RYR1	c.5317C>T	\N	f	f
3685516	43	RYR1	c.5341T>C	\N	f	f
3685518	43	RYR1	c.5360C>T	\N	f	f
3685520	43	RYR1	c.5440A>G	\N	f	f
3685522	43	RYR1	c.5441T>A	\N	f	f
3685524	43	RYR1	c.5890C>T	\N	f	f
3685526	43	RYR1	c.6037A>C	\N	f	f
3685528	43	RYR1	c.6178G>T	\N	f	f
3685530	43	RYR1	c.6302T>A	\N	f	f
3685532	43	RYR1	c.6304G>C	\N	f	f
3685536	43	RYR1	c.6377G>A	\N	f	f
3685538	43	RYR1	c.6387C>G	\N	f	f
3685540	43	RYR1	c.6388G>A	\N	f	f
3685542	43	RYR1	c.6478G>A	\N	f	f
779186	104	RYR1	c.6487C>T	\N	f	f
3685550	43	RYR1	c.6488G>T	\N	f	f
779190	104	RYR1	c.6502G>A	\N	f	f
3685580	43	RYR1	c.6743G>A	\N	f	f
779202	104	RYR1	c.7063C>T	\N	f	f
779206	104	RYR1	c.7282G>A	\N	f	f
3685646	43	RYR1	c.7292A>T	\N	f	f
779220	104	RYR1	c.7373G>A	\N	f	f
3685704	43	RYR1	c.7879G>C	\N	f	f
3685734	43	RYR1	c.8654C>G	\N	f	f
3685794	43	RYR1	c.11120G>T	\N	f	f
3685824	43	RYR1	c.11958C>G	\N	f	f
3685854	43	RYR1	c.12533G>T	\N	f	f
3685884	43	RYR1	c.13918A>G	\N	f	f
3685914	43	RYR1	c.14422_14423delinsAA	\N	f	f
779474	104	TPMT	*40	\N	f	f
779476	104	TPMT	*41	\N	f	f
779478	104	TPMT	*42	\N	f	f
779480	104	TPMT	*43	\N	f	f
779482	104	TPMT	*44	\N	f	f
779488	104	UGT1A1	*1	\N	t	f
779490	104	UGT1A1	*6	\N	f	f
779492	104	UGT1A1	*27	\N	f	f
779494	104	UGT1A1	*28	\N	f	f
779496	104	UGT1A1	*36	\N	f	f
779498	104	UGT1A1	*37	\N	f	f
779502	104	UGT1A1	*80+*28	\N	f	f
779504	104	UGT1A1	*80+*37	\N	f	f
779507	104	VKORC1	rs9923231 reference (C)	\N	t	f
779509	104	VKORC1	rs9923231 variant (T)	\N	f	f
777424	186	CYP2B6	*2	\N	f	f
777426	186	CYP2B6	*3	\N	f	f
2899144	100	CYP2B6	*40	\N	f	f
2899160	100	CYP2B6	*48	\N	f	f
777586	186	CYP2C19	*31	\N	f	f
777596	181	CYP2C19	*36	\N	f	t
777668	186	CYP2C9	*1	\N	t	f
777708	186	CYP2C9	*21	\N	f	f
777718	186	CYP2C9	*26	\N	f	f
777736	186	CYP2C9	*35	\N	f	f
777754	186	CYP2C9	*44	\N	f	f
777808	186	CYP2C9	*71	\N	f	f
1932995	136	CYP2C9	*81	\N	f	f
777960	181	CYP2D6	*13	\N	f	t
778104	186	CYP2D6	*93	\N	f	f
778134	186	CYP2D6	*108	\N	f	f
778154	186	CYP2D6	*118	\N	f	f
778158	186	CYP2D6	*120	\N	f	f
778194	186	CYP2D6	*138	\N	f	f
778198	186	CYP2D6	*140	\N	f	f
2091240	130	CYP2D6	*154	\N	f	f
2091248	130	CYP2D6	*158	\N	f	f
2677041	108	CYP2D6	*165	\N	f	f
778238	185	CYP4F2	*1	\N	t	f
3318591	85	CYP4F2	*11	\N	f	f
778327	104	DPYD	Reference	\N	t	f
778329	104	DPYD	c.46C>G	\N	f	f
778331	104	DPYD	c.61C>T	\N	f	f
778333	104	DPYD	c.62G>A	\N	f	f
778335	104	DPYD	c.85T>C (*9A)	\N	f	f
778339	104	DPYD	c.313G>A	\N	f	f
778341	104	DPYD	c.343A>G	\N	f	f
778343	104	DPYD	c.451A>G	\N	f	f
778345	104	DPYD	c.496A>G	\N	f	f
778347	104	DPYD	c.498G>A	\N	f	f
778349	104	DPYD	c.525G>A	\N	f	f
778351	104	DPYD	c.557A>G	\N	f	f
778353	104	DPYD	c.601A>C	\N	f	f
778355	104	DPYD	c.632A>G	\N	f	f
778357	104	DPYD	c.703C>T (*8)	\N	f	f
778359	104	DPYD	c.775A>G	\N	f	f
778361	104	DPYD	c.868A>G	\N	f	f
778363	104	DPYD	c.929T>C	\N	f	f
778365	104	DPYD	c.934C>T	\N	f	f
778367	104	DPYD	c.967G>A	\N	f	f
778369	104	DPYD	c.1003G>T (*11)	\N	f	f
778371	104	DPYD	c.1024G>A	\N	f	f
778373	104	DPYD	c.1057C>T	\N	f	f
778375	104	DPYD	c.1108A>G	\N	f	f
3942827	36	DPYD	c.1129-5923C>G	\N	f	f
778377	104	DPYD	c.1129-5923C>G, c.1236G>A (HapB3)	\N	f	f
778379	104	DPYD	c.1156G>T (*12)	\N	f	f
778381	104	DPYD	c.1180C>T	\N	f	f
778383	104	DPYD	c.1181G>T	\N	f	f
778385	104	DPYD	c.1218G>A	\N	f	f
778387	104	DPYD	c.1260T>A	\N	f	f
778389	104	DPYD	c.1278G>T	\N	f	f
778393	104	DPYD	c.1314T>G	\N	f	f
778395	104	DPYD	c.1349C>T	\N	f	f
778397	104	DPYD	c.1358C>G	\N	f	f
778399	104	DPYD	c.1371C>T	\N	f	f
778401	104	DPYD	c.1403C>A	\N	f	f
778403	104	DPYD	c.1475C>T	\N	f	f
778405	104	DPYD	c.1484A>G	\N	f	f
778407	104	DPYD	c.1519G>A	\N	f	f
778409	104	DPYD	c.1543G>A	\N	f	f
778411	104	DPYD	c.1577C>G	\N	f	f
778413	104	DPYD	c.1601G>A (*4)	\N	f	f
778415	104	DPYD	c.1615G>A	\N	f	f
778417	104	DPYD	c.1627A>G (*5)	\N	f	f
778419	104	DPYD	c.1679T>G (*13)	\N	f	f
778423	104	DPYD	c.1774C>T	\N	f	f
778425	104	DPYD	c.1775G>A	\N	f	f
778427	104	DPYD	c.1777G>A	\N	f	f
778429	104	DPYD	c.1796T>C	\N	f	f
778431	104	DPYD	c.1896T>C	\N	f	f
778433	104	DPYD	c.1898delC (*3)	\N	f	f
778437	104	DPYD	c.1905+1G>A (*2A)	\N	f	f
778445	104	DPYD	c.2161G>A	\N	f	f
778447	104	DPYD	c.2186C>T	\N	f	f
778449	104	DPYD	c.2194G>A (*6)	\N	f	f
778451	104	DPYD	c.2195T>G	\N	f	f
778455	104	DPYD	c.2303C>A	\N	f	f
778457	104	DPYD	c.2336C>A	\N	f	f
778459	104	DPYD	c.2482G>A	\N	f	f
778463	104	DPYD	c.2623A>C	\N	f	f
778465	104	DPYD	c.2639G>T	\N	f	f
778467	104	DPYD	c.2656C>T	\N	f	f
778469	104	DPYD	c.2657G>A (*9B)	\N	f	f
778471	104	DPYD	c.2846A>T	\N	f	f
778473	104	DPYD	c.2872A>G	\N	f	f
778475	104	DPYD	c.2915A>G	\N	f	f
778477	104	DPYD	c.2921A>T	\N	f	f
778479	104	DPYD	c.2933A>G	\N	f	f
778481	104	DPYD	c.2978T>G	\N	f	f
778487	104	DPYD	c.3049G>A	\N	f	f
778489	104	DPYD	c.3061G>C	\N	f	f
778491	104	DPYD	c.3067C>A	\N	f	f
779148	104	RYR1	Reference	\N	t	f
3685308	43	RYR1	c.38T>G	\N	f	f
3685312	43	RYR1	c.97A>G	\N	f	f
779150	104	RYR1	c.103T>C	\N	f	f
3685316	43	RYR1	c.119G>C	\N	f	f
779152	104	RYR1	c.130C>T	\N	f	f
3685320	43	RYR1	c.131G>A	\N	f	f
3685322	43	RYR1	c.152C>A	\N	f	f
3685324	43	RYR1	c.178G>A	\N	f	f
3685326	43	RYR1	c.178G>T	\N	f	f
3685328	43	RYR1	c.190T>C	\N	f	f
3685330	43	RYR1	c.212C>A	\N	f	f
3685366	43	RYR1	c.625G>A	\N	f	f
779188	104	RYR1	c.6488G>A	\N	f	f
3685548	43	RYR1	c.6488G>C	\N	f	f
3685556	43	RYR1	c.6548G>A	\N	f	f
3685558	43	RYR1	c.6599C>T	\N	f	f
3685560	43	RYR1	c.6612C>G	\N	f	f
779192	104	RYR1	c.6617C>G	\N	f	f
779194	104	RYR1	c.6617C>T	\N	f	f
3685566	43	RYR1	c.6628G>T	\N	f	f
3685568	43	RYR1	c.6635T>A	\N	f	f
3685570	43	RYR1	c.6640G>A	\N	f	f
3685572	43	RYR1	c.6671G>A	\N	f	f
3685574	43	RYR1	c.6670C>T	\N	f	f
3685576	43	RYR1	c.6710G>A	\N	f	f
3685578	43	RYR1	c.6742C>T	\N	f	f
3685582	43	RYR1	c.6757C>T	\N	f	f
3685584	43	RYR1	c.6838G>A	\N	f	f
3685588	43	RYR1	c.6961A>G	\N	f	f
779196	104	RYR1	c.7007G>A	\N	f	f
3685592	43	RYR1	c.7018T>C	\N	f	f
3685982	43	RYR1	c.15060G>C	\N	f	f
3685984	43	RYR1	c.14364+1G>T	\N	f	f
777264	104	CACNA1S	c.520C>T	\N	f	f
777307	104	CFTR	ivacaftor non-responsive CFTR sequence	\N	t	f
777315	104	CFTR	711+3A->G	\N	f	f
777309	104	CFTR	2789+5G->A	\N	f	f
777311	104	CFTR	3272-26A->G	\N	f	f
777313	104	CFTR	3849+10kbC->T	\N	f	f
777319	104	CFTR	A455E	\N	f	f
777317	104	CFTR	A1067T	\N	f	f
777321	104	CFTR	D110E	\N	f	f
777323	104	CFTR	D110H	\N	f	f
777329	104	CFTR	D579G	\N	f	f
777325	104	CFTR	D1152H	\N	f	f
777327	104	CFTR	D1270N	\N	f	f
777331	104	CFTR	E193K	\N	f	f
777335	104	CFTR	E831X	\N	f	f
777337	104	CFTR	F1052V	\N	f	f
777347	104	CFTR	G178R	\N	f	f
777349	104	CFTR	G551D	\N	f	f
777351	104	CFTR	G551S	\N	f	f
777341	104	CFTR	G1069R	\N	f	f
777343	104	CFTR	G1244E	\N	f	f
777345	104	CFTR	G1349D	\N	f	f
777353	104	CFTR	K1060T	\N	f	f
777355	104	CFTR	L206W	\N	f	f
777371	104	CFTR	R74W	\N	f	f
777363	104	CFTR	R117C	\N	f	f
777365	104	CFTR	R117H	\N	f	f
777367	104	CFTR	R347H	\N	f	f
777369	104	CFTR	R352Q	\N	f	f
777359	104	CFTR	R1070Q	\N	f	f
777361	104	CFTR	R1070W	\N	f	f
777381	104	CFTR	S549R(T>G)	\N	f	f
777383	104	CFTR	S945L	\N	f	f
777385	104	CFTR	S977F	\N	f	f
777373	104	CFTR	S1251N	\N	f	f
777375	104	CFTR	S1255P	\N	f	f
777582	186	CYP2C19	*29	\N	f	f
777584	186	CYP2C19	*30	\N	f	f
777588	186	CYP2C19	*32	\N	f	f
777590	186	CYP2C19	*33	\N	f	f
778100	186	CYP2D6	*91	\N	f	f
778102	186	CYP2D6	*92	\N	f	f
778106	186	CYP2D6	*94	\N	f	f
778110	186	CYP2D6	*96	\N	f	f
778160	186	CYP2D6	*121	\N	f	f
778174	186	CYP2D6	*128	\N	f	f
778439	104	DPYD	c.1906A>C	\N	f	f
778441	104	DPYD	c.1990G>T	\N	f	f
778443	104	DPYD	c.2021G>A	\N	f	f
778666	105	G6PD	B (reference)	\N	t	f
778748	104	G6PD	A- 680T_376G	\N	f	f
778750	104	G6PD	A- 968C_376G	\N	f	f
778916	104	G6PD	Aachen	\N	f	f
778962	104	G6PD	Abeno	\N	f	f
778950	104	G6PD	Alhambra	\N	f	f
778702	104	G6PD	Amazonia	\N	f	f
779006	104	G6PD	Amiens	\N	f	f
778700	104	G6PD	Amsterdam	\N	f	f
778956	104	G6PD	Anadia	\N	f	f
778746	104	G6PD	Ananindeua	\N	f	f
779036	104	G6PD	Arakawa	\N	f	f
778708	104	G6PD	Asahi	\N	f	f
778686	104	G6PD	Aures	\N	f	f
778858	104	G6PD	Bajo Maumere	\N	f	f
778844	104	G6PD	Bangkok	\N	f	f
779008	104	G6PD	Bangkok Noi	\N	f	f
778738	104	G6PD	Bao Loc	\N	f	f
778952	104	G6PD	Bari	\N	f	f
778766	104	G6PD	Belem	\N	f	f
779034	104	G6PD	Buenos Aires	\N	f	f
778762	104	G6PD	Cairo	\N	f	f
778922	104	G6PD	Calvo Mackenna	\N	f	f
779032	104	G6PD	Campinas	\N	f	f
778994	104	G6PD	Cassano	\N	f	f
778894	104	G6PD	Chatham	\N	f	f
778794	104	G6PD	Chikugo	\N	f	f
778854	104	G6PD	Chinese-1	\N	f	f
778900	104	G6PD	Chinese-5	\N	f	f
778816	104	G6PD	Cincinnati	\N	f	f
778840	104	G6PD	Cleveland Corum	\N	f	f
778674	104	G6PD	Gaohe	\N	f	f
778978	104	G6PD	Georgia	\N	f	f
778936	104	G6PD	Guadalajara	\N	f	f
778726	104	G6PD	Guangzhou	\N	f	f
778852	104	G6PD	Haikou	\N	f	f
778734	104	G6PD	Hammersmith	\N	f	f
778818	104	G6PD	Harilaou	\N	f	f
778998	104	G6PD	Harima	\N	f	f
778940	104	G6PD	Hartford	\N	f	f
778710	104	G6PD	Hechi	\N	f	f
778996	104	G6PD	Hermoupolis	\N	f	f
778676	104	G6PD	Honiara	\N	f	f
778770	104	G6PD	Ilesha	\N	f	f
778890	104	G6PD	Insuli	\N	f	f
778908	104	G6PD	Iwatsuki	\N	f	f
778970	104	G6PD	Japan, Shinagawa	\N	f	f
779022	104	G6PD	Kaiping, Anant, Dhon, Sapporo-like, Wosera	\N	f	f
778880	104	G6PD	Kalyan-Kerala, Jamnaga, Rohini	\N	f	f
778688	104	G6PD	Kambos	\N	f	f
779016	104	G6PD	Kamiube, Keelung	\N	f	f
778692	104	G6PD	Kamogawa	\N	f	f
778972	104	G6PD	Kawasaki	\N	f	f
778690	104	G6PD	Kozukata	\N	f	f
778944	104	G6PD	Krakow	\N	f	f
778848	104	G6PD	La Jolla	\N	f	f
778672	104	G6PD	Lages	\N	f	f
779026	104	G6PD	Laibin	\N	f	f
778842	104	G6PD	Lille	\N	f	f
778768	104	G6PD	Liuzhou	\N	f	f
778914	104	G6PD	Loma Linda	\N	f	f
778878	104	G6PD	Ludhiana	\N	f	f
778930	104	G6PD	Lynwood	\N	f	f
778932	104	G6PD	Madrid	\N	f	f
778776	104	G6PD	Mahidol	\N	f	f
778796	104	G6PD	Malaga	\N	f	f
778984	104	G6PD	Mediterranean Haplotype	\N	f	f
778696	104	G6PD	Metaponto	\N	f	f
778822	104	G6PD	Mexico City	\N	f	f
778790	104	G6PD	Miaoli	\N	f	f
778814	104	G6PD	Minnesota, Marion, Gastonia, LeJeune	\N	f	f
778902	104	G6PD	Mira d'Aire	\N	f	f
778860	104	G6PD	Mizushima	\N	f	f
778868	104	G6PD	Montalbano	\N	f	f
778920	104	G6PD	Montpellier	\N	f	f
778754	104	G6PD	Mt Sinai	\N	f	f
778974	104	G6PD	Munich	\N	f	f
6481202	25	NAT2	*14	\N	f	f
6481214	25	NAT2	*29	\N	f	f
6481224	25	NAT2	*34	\N	f	f
6481234	25	NAT2	*39	\N	f	f
6481242	25	NAT2	*43	\N	f	f
6481252	25	NAT2	*48	\N	f	f
6481260	25	NAT2	*52	\N	f	f
6481270	25	NAT2	*57	\N	f	f
6481278	25	NAT2	*61	\N	f	f
779295	179	SLCO1B1	*10	\N	f	f
778804	104	G6PD	Coimbra Shunde	\N	f	f
779010	104	G6PD	Cosenza	\N	f	f
778698	104	G6PD	Costanzo	\N	f	f
778958	104	G6PD	Covao do Lobo	\N	f	f
778740	104	G6PD	Crispim	\N	f	f
778810	104	G6PD	Dagua	\N	f	f
778830	104	G6PD	Durham	\N	f	f
778888	104	G6PD	Farroupilha	\N	f	f
779018	104	G6PD	Flores	\N	f	f
779030	104	G6PD	Fukaya	\N	f	f
778896	104	G6PD	Fushan	\N	f	f
778680	104	G6PD	Gidra	\N	f	f
778718	104	G6PD	Murcia Oristano	\N	f	f
778704	104	G6PD	Musashino	\N	f	f
778716	104	G6PD	Namouru	\N	f	f
778788	104	G6PD	Nankang	\N	f	f
778828	104	G6PD	Nanning	\N	f	f
778784	104	G6PD	Naone	\N	f	f
778882	104	G6PD	Nara	\N	f	f
779024	104	G6PD	Neapolis	\N	f	f
779014	104	G6PD	Nice	\N	f	f
778808	104	G6PD	Nilgiri	\N	f	f
778668	104	G6PD	No name	\N	f	f
778824	104	G6PD	North Dallas	\N	f	f
778926	104	G6PD	Olomouc	\N	f	f
778876	104	G6PD	Omiya	\N	f	f
778684	104	G6PD	Orissa	\N	f	f
778866	104	G6PD	Osaka	\N	f	f
778694	104	G6PD	Palestrina	\N	f	f
778862	104	G6PD	Papua	\N	f	f
778904	104	G6PD	Partenope	\N	f	f
778986	104	G6PD	Pawnee	\N	f	f
778864	104	G6PD	Piotrkow	\N	f	f
778778	104	G6PD	Plymouth	\N	f	f
778942	104	G6PD	Praha	\N	f	f
778760	104	G6PD	Quing Yan	\N	f	f
778820	104	G6PD	Radlowo	\N	f	f
778886	104	G6PD	Rehevot	\N	f	f
778682	104	G6PD	Rignano	\N	f	f
778924	104	G6PD	Riley	\N	f	f
778838	104	G6PD	Roubaix	\N	f	f
778992	104	G6PD	S. Antioco	\N	f	f
778758	104	G6PD	Salerno Pyrgos	\N	f	f
778806	104	G6PD	Santiago	\N	f	f
778736	104	G6PD	Sao Borja	\N	f	f
778856	104	G6PD	Seattle, Lodi, Modena, Ferrara II, Athens-like	\N	f	f
778874	104	G6PD	Seoul	\N	f	f
778910	104	G6PD	Serres	\N	f	f
778772	104	G6PD	Shenzen	\N	f	f
778792	104	G6PD	Shinshu	\N	f	f
778812	104	G6PD	Sibari	\N	f	f
778730	104	G6PD	Sierra Leone	\N	f	f
778670	104	G6PD	Sinnai	\N	f	f
778706	104	G6PD	Songklanagarind	\N	f	f
779028	104	G6PD	Split	\N	f	f
778846	104	G6PD	Sugao	\N	f	f
778982	104	G6PD	Sumare	\N	f	f
778678	104	G6PD	Sunderland	\N	f	f
778980	104	G6PD	Surabaya	\N	f	f
778966	104	G6PD	Suwalki	\N	f	f
778720	104	G6PD	Swansea	\N	f	f
3564276	45	G6PD	Telti, Kobe	\N	f	f
778918	104	G6PD	Tenri	\N	f	f
778976	104	G6PD	Tokyo, Fukushima	\N	f	f
778782	104	G6PD	Toledo	\N	f	f
778928	104	G6PD	Tomah	\N	f	f
778912	104	G6PD	Tondela	\N	f	f
778898	104	G6PD	Torun	\N	f	f
778798	104	G6PD	Tsukui	\N	f	f
779000	104	G6PD	Union,Maewo, Chinese-2, Kalo	\N	f	f
778728	104	G6PD	Urayasu	\N	f	f
778964	104	G6PD	Utrecht	\N	f	f
778764	104	G6PD	Valladolid	\N	f	f
778732	104	G6PD	Vancouver	\N	f	f
778756	104	G6PD	Vanua Lava	\N	f	f
778870	104	G6PD	Viangchan, Jammu	\N	f	f
778892	104	G6PD	Villeurbanne	\N	f	f
778786	104	G6PD	Volendam	\N	f	f
778834	104	G6PD	Wayne	\N	f	f
778850	104	G6PD	Wexham	\N	f	f
3685618	43	RYR1	c.7084G>A	\N	f	f
3685620	43	RYR1	c.7085A>G	\N	f	f
3685624	43	RYR1	c.7090T>G	\N	f	f
3685626	43	RYR1	c.7097C>G	\N	f	f
3685628	43	RYR1	c.7099G>A	\N	f	f
3685630	43	RYR1	c.7112A>G	\N	f	f
3685632	43	RYR1	c.7123G>A	\N	f	f
779204	104	RYR1	c.7124G>C	\N	f	f
3685636	43	RYR1	c.7199A>G	\N	f	f
3685638	43	RYR1	c.7210G>A	\N	f	f
3685642	43	RYR1	c.7291G>A	\N	f	f
3685644	43	RYR1	c.7291G>T	\N	f	f
779208	104	RYR1	c.7300G>A	\N	f	f
779210	104	RYR1	c.7304G>A	\N	f	f
3685652	43	RYR1	c.7304G>T	\N	f	f
3685654	43	RYR1	c.7307G>A	\N	f	f
3685658	43	RYR1	c.7317G>C	\N	f	f
779212	104	RYR1	c.7354C>T	\N	f	f
3685662	43	RYR1	c.7355G>A	\N	f	f
3685664	43	RYR1	c.7355G>C	\N	f	f
3685666	43	RYR1	c.7358T>C	\N	f	f
779214	104	RYR1	c.7360C>T	\N	f	f
779216	104	RYR1	c.7361G>A	\N	f	f
779218	104	RYR1	c.7372C>T	\N	f	f
3685676	43	RYR1	c.7373G>T	\N	f	f
3685678	43	RYR1	c.7385C>T	\N	f	f
3685680	43	RYR1	c.7487C>T	\N	f	f
779222	104	RYR1	c.7522C>T	\N	f	f
779224	104	RYR1	c.7522C>G	\N	f	f
779226	104	RYR1	c.7523G>A	\N	f	f
3685690	43	RYR1	c.7760A>G	\N	f	f
3685692	43	RYR1	c.7771C>G	\N	f	f
3685696	43	RYR1	c.7777C>G	\N	f	f
3685698	43	RYR1	c.7778G>A	\N	f	f
3685700	43	RYR1	c.7787C>T	\N	f	f
3685702	43	RYR1	c.7816T>A	\N	f	f
3685706	43	RYR1	c.7879G>A	\N	f	f
3685708	43	RYR1	c.8005G>A	\N	f	f
3685710	43	RYR1	c.8026C>T	\N	f	f
3685712	43	RYR1	c.8054C>T	\N	f	f
3685714	43	RYR1	c.8188G>C	\N	f	f
3685716	43	RYR1	c.8189A>G	\N	f	f
3685718	43	RYR1	c.8198G>A	\N	f	f
3685720	43	RYR1	c.8290G>A	\N	f	f
3685724	43	RYR1	c.8360C>G	\N	f	f
3685728	43	RYR1	c.8527T>C	\N	f	f
3685730	43	RYR1	c.8600T>A	\N	f	f
3685732	43	RYR1	c.8638G>A	\N	f	f
3685736	43	RYR1	c.8729C>T	\N	f	f
3685738	43	RYR1	c.8926C>T	\N	f	f
3685740	43	RYR1	c.9152G>A	\N	f	f
3685742	43	RYR1	c.9268G>A	\N	f	f
1508724	85	ABCG2	rs2231142 reference (G)	\N	t	f
1508726	85	ABCG2	rs2231142 variant (T)	\N	f	f
777262	104	CACNA1S	Reference	\N	t	f
777266	104	CACNA1S	c.3257G>A	\N	f	f
6355213	14	CFTR	A120T	\N	f	f
6355249	14	CFTR	F508C	\N	f	f
6606011	12	CFTR	F508C,S1251N	\N	f	f
6355297	14	CFTR	I1139V	\N	f	f
6355329	14	CFTR	Q359R	\N	f	f
6355367	14	CFTR	R1162L	\N	f	f
6355369	14	CFTR	R1283M	\N	f	f
777377	104	CFTR	S549N	\N	f	f
6355387	14	CFTR	S1159P	\N	f	f
777422	186	CYP2B6	*1	\N	t	f
8101105	1	CYP2D6	*186	\N	f	f
8101126	1	CYP3A5	*10	\N	f	f
8101128	1	CYP3A5	*11	\N	f	f
778391	104	DPYD	c.1294G>A	\N	f	f
778421	104	DPYD	c.1682G>T	\N	f	f
778461	104	DPYD	c.2582A>G	\N	f	f
778836	104	G6PD	Aveiro	\N	f	f
779012	104	G6PD	Canton, Taiwan-Hakka, Gifu-like, Agrigento-like	\N	f	f
778960	104	G6PD	Clinic	\N	f	f
779004	104	G6PD	Figuera da Foz	\N	f	f
778934	104	G6PD	Iowa, Walter Reed, Springfield	\N	f	f
778884	104	G6PD	Manhattan	\N	f	f
778948	104	G6PD	Nashville, Anaheim, Portici	\N	f	f
778968	104	G6PD	Riverside	\N	f	f
778832	104	G6PD	Stonybrook	\N	f	f
778722	104	G6PD	Ube Konan	\N	f	f
778946	104	G6PD	Wisconsin	\N	f	f
779020	104	G6PD	Yunan	\N	f	f
8102296	1	NUDT15	*22	\N	f	f
8102298	1	NUDT15	*23	\N	f	f
3685310	43	RYR1	c.51_53del	\N	f	f
3685360	43	RYR1	c.529C>T	\N	f	f
3685386	43	RYR1	c.992_994dup	\N	f	f
8102726	1	RYR1	c.1390C>A	\N	f	f
3685414	43	RYR1	c.1422G>T	\N	f	f
779180	104	RYR1	c.1654C>T	\N	f	f
3685474	43	RYR1	c.3166G>A	\N	f	f
8102806	1	RYR1	c.4055C>G	\N	f	f
8102820	1	RYR1	c.4999C>T	\N	f	f
3685504	43	RYR1	c.5033A>G	\N	f	f
3685534	43	RYR1	c.6349G>C	\N	f	f
3685554	43	RYR1	c.6544A>T	\N	f	f
3685586	43	RYR1	c.6847A>C	\N	f	f
3685594	43	RYR1	c.7025A>G	\N	f	f
3685596	43	RYR1	c.7032G>C	\N	f	f
3685598	43	RYR1	c.7035C>A	\N	f	f
3685600	43	RYR1	c.7036G>A	\N	f	f
779198	104	RYR1	c.7042_7044delGAG	\N	f	f
3685604	43	RYR1	c.7043A>G	\N	f	f
779200	104	RYR1	c.7048G>A	\N	f	f
3685608	43	RYR1	c.7060G>A	\N	f	f
3685612	43	RYR1	c.7073T>A	\N	f	f
3685614	43	RYR1	c.7076G>A	\N	f	f
3685616	43	RYR1	c.7075C>T	\N	f	f
3685622	43	RYR1	c.7089C>G	\N	f	f
3685656	43	RYR1	c.7310C>T	\N	f	f
3685688	43	RYR1	c.7528T>C	\N	f	f
8103010	1	RYR1	c.7625G>A	\N	f	f
3685722	43	RYR1	c.8327C>T	\N	f	f
779228	104	RYR1	c.9310G>A	\N	f	f
8103068	1	RYR1	c.9353C>T	\N	f	f
3685746	43	RYR1	c.9356G>A	\N	f	f
3685748	43	RYR1	c.9499C>T	\N	f	f
3685750	43	RYR1	c.9635A>G	\N	f	f
3685752	43	RYR1	c.9649T>C	\N	f	f
3685754	43	RYR1	c.9652G>A	\N	f	f
3685756	43	RYR1	c.9676G>C	\N	f	f
3685760	43	RYR1	c.9797T>C	\N	f	f
3685762	43	RYR1	c.9848G>A	\N	f	f
3685764	43	RYR1	c.9850T>A	\N	f	f
3685766	43	RYR1	c.9868G>A	\N	f	f
3685768	43	RYR1	c.10042C>T	\N	f	f
3685770	43	RYR1	c.10043G>A	\N	f	f
3685772	43	RYR1	c.10097G>A	\N	f	f
3685774	43	RYR1	c.10100A>G	\N	f	f
3685776	43	RYR1	c.10229C>A	\N	f	f
3685778	43	RYR1	c.10237A>T	\N	f	f
3685780	43	RYR1	c.10252A>G	\N	f	f
3685782	43	RYR1	c.10556C>T	\N	f	f
3685784	43	RYR1	c.10616G>A	\N	f	f
3685786	43	RYR1	c.10747G>C	\N	f	f
3685788	43	RYR1	c.10750G>C	\N	f	f
3685792	43	RYR1	c.11086G>C	\N	f	f
3685796	43	RYR1	c.11126C>T	\N	f	f
3685798	43	RYR1	c.11132C>T	\N	f	f
3685800	43	RYR1	c.11266C>G	\N	f	f
3685802	43	RYR1	c.11315G>A	\N	f	f
3685804	43	RYR1	c.11314C>T	\N	f	f
3685806	43	RYR1	c.11416G>A	\N	f	f
3685808	43	RYR1	c.11518G>A	\N	f	f
3685810	43	RYR1	c.11708G>A	\N	f	f
3685812	43	RYR1	c.11723A>T	\N	f	f
3685814	43	RYR1	c.11748T>G	\N	f	f
3685816	43	RYR1	c.11798A>G	\N	f	f
3685818	43	RYR1	c.11813G>A	\N	f	f
3685820	43	RYR1	c.11947C>T	\N	f	f
779230	104	RYR1	c.11969G>T	\N	f	f
3685828	43	RYR1	c.12028G>A	\N	f	f
3685830	43	RYR1	c.12064A>G	\N	f	f
3685832	43	RYR1	c.12115A>T	\N	f	f
3685834	43	RYR1	c.12121C>T	\N	f	f
3685836	43	RYR1	c.12149C>A	\N	f	f
3685838	43	RYR1	c.12242C>T	\N	f	f
3685840	43	RYR1	c.12310G>C	\N	f	f
3685842	43	RYR1	c.12355A>T	\N	f	f
3685844	43	RYR1	c.12383C>T	\N	f	f
3685846	43	RYR1	c.12398A>G	\N	f	f
3685848	43	RYR1	c.12406C>A	\N	f	f
3685850	43	RYR1	c.12413T>C	\N	f	f
3685852	43	RYR1	c.12532G>A	\N	f	f
3685858	43	RYR1	c.12689T>G	\N	f	f
3685860	43	RYR1	c.12700G>C	\N	f	f
3685862	43	RYR1	c.12700G>T	\N	f	f
3685864	43	RYR1	c.12848A>T	\N	f	f
3685866	43	RYR1	c.12881C>T	\N	f	f
3685868	43	RYR1	c.12884C>T	\N	f	f
8103194	1	RYR1	c.13502C>T	\N	f	f
3685870	43	RYR1	c.13505A>G	\N	f	f
3685872	43	RYR1	c.13513G>C	\N	f	f
779500	104	UGT1A1	*80	\N	f	f
8104052	1	CYP2D6	*68+*4	\N	f	f
8104054	1	CYP2D6	*36+*10	\N	f	f
8104056	1	CYP2D6	*13+*1	\N	f	f
8104059	1	CYP2D6	*13+*2	\N	f	f
8104061	1	CYP2D6	*13+*68x2+*4	\N	f	f
8104063	1	CYP2D6	*36x2+*10	\N	f	f
8104066	1	CYP2D6	*68+*2	\N	f	f
\.


--
-- Data for Name: allele_frequency; Type: TABLE DATA; Schema: cpic; Owner: -
--

COPY cpic.allele_frequency (alleleid, population, frequency, label, version) FROM stdin;
1508725	8217608	0.926	0.9260	1
1508727	8217608	0.074	0.0740	1
1508725	8217609	0.99	0.9900	1
1508727	8217609	0.01	0.0100	1
1508725	8217610	0.8	0.8000	1
1508727	8217610	0.2	0.2000	1
1508725	8217611	0.9068	0.9068	1
1508727	8217611	0.0932	0.0932	1
1508725	8217612	0.6929	0.6929	1
1508727	8217612	0.3071	0.3071	1
1508725	8217613	0.8964	0.8964	1
1508727	8217613	0.1036	0.1036	1
1508725	8217614	0.7756	0.7756	1
1508727	8217614	0.2244	0.2244	1
1508725	8217615	0.9347	0.9347	1
1508727	8217615	0.0653	0.0653	1
1508725	8217616	0.903	0.9030	1
1508727	8217616	0.097	0.0970	1
1508725	8217617	0.893	0.8930	1
1508727	8217617	0.107	0.1070	1
1508725	8217618	0.798	0.7980	1
1508727	8217618	0.202	0.2020	1
1508725	8217619	0.561	0.5610	1
1508727	8217619	0.439	0.4390	1
1508725	8217620	1	1.0000	1
1508727	8217620	0	0.0	1
1508725	8217621	1	1.0000	1
1508727	8217621	0	0.0	1
1508725	8217622	0.987	0.9870	1
1508727	8217622	0.013	0.0130	1
1508725	8217623	0.982	0.9820	1
1508727	8217623	0.018	0.0180	1
1508725	8217624	1	1.0000	1
1508727	8217624	0	0.0	1
777265	8217625	0.00003267	3.267E-5	1
777267	8217625	\N	\N	1
777265	8217626	\N	\N	1
777267	8217626	0	0.0	1
777265	8217627	0.0001087	1.087E-4	1
777267	8217627	0	0.0	1
777265	8217628	0.00001759	1.759E-5	1
777267	8217628	\N	\N	1
777265	8217629	0	0.0	1
777267	8217629	\N	\N	1
777265	8217630	\N	\N	1
777267	8217630	0	0.0	1
777265	8217631	\N	\N	1
777267	8217631	0	0.0	1
777265	8217632	0.00005783	5.783E-5	1
777267	8217632	\N	\N	1
777265	8217633	\N	\N	1
777267	8217633	0.00002891	2.891E-5	1
777265	8217634	0	0.0	1
777267	8217634	\N	\N	1
777265	8217635	\N	\N	1
777267	8217635	0	0.0	1
777425	8217636	\N	\N	1
777427	8217636	0	0.0	1
777429	8217636	\N	\N	1
777431	8217636	\N	\N	1
777433	8217636	\N	\N	1
777435	8217636	\N	\N	1
777437	8217636	\N	\N	1
777439	8217636	\N	\N	1
777441	8217636	\N	\N	1
777443	8217636	\N	\N	1
777445	8217636	\N	\N	1
777447	8217636	\N	\N	1
777449	8217636	\N	\N	1
777451	8217636	\N	\N	1
777453	8217636	\N	\N	1
777455	8217636	\N	\N	1
777457	8217636	\N	\N	1
777459	8217636	\N	\N	1
777461	8217636	\N	\N	1
777463	8217636	\N	\N	1
777465	8217636	\N	\N	1
777467	8217636	\N	\N	1
777469	8217636	\N	\N	1
777471	8217636	\N	\N	1
777473	8217636	\N	\N	1
777475	8217636	\N	\N	1
777477	8217636	\N	\N	1
777479	8217636	\N	\N	1
777481	8217636	\N	\N	1
777483	8217636	\N	\N	1
777485	8217636	\N	\N	1
777487	8217636	\N	\N	1
777489	8217636	\N	\N	1
777491	8217636	\N	\N	1
777493	8217636	\N	\N	1
777495	8217636	\N	\N	1
778233	8218957	\N	\N	1
777425	8217637	\N	\N	1
777427	8217637	\N	\N	1
777429	8217637	\N	\N	1
777431	8217637	\N	\N	1
777433	8217637	0.35	0.35	1
777435	8217637	\N	\N	1
777437	8217637	\N	\N	1
777439	8217637	\N	\N	1
777441	8217637	\N	\N	1
777443	8217637	\N	\N	1
777445	8217637	\N	\N	1
777447	8217637	\N	\N	1
777449	8217637	\N	\N	1
777451	8217637	\N	\N	1
777453	8217637	\N	\N	1
777455	8217637	0.04	0.04	1
777457	8217637	\N	\N	1
777459	8217637	\N	\N	1
777461	8217637	\N	\N	1
777463	8217637	\N	\N	1
777465	8217637	\N	\N	1
777467	8217637	\N	\N	1
777469	8217637	\N	\N	1
777471	8217637	\N	\N	1
777473	8217637	\N	\N	1
777475	8217637	\N	\N	1
777477	8217637	\N	\N	1
777479	8217637	\N	\N	1
777481	8217637	\N	\N	1
777483	8217637	\N	\N	1
777485	8217637	\N	\N	1
777487	8217637	\N	\N	1
777489	8217637	\N	\N	1
777491	8217637	\N	\N	1
777493	8217637	\N	\N	1
777495	8217637	\N	\N	1
777425	8217638	\N	\N	1
777427	8217638	\N	\N	1
777429	8217638	\N	\N	1
777431	8217638	\N	\N	1
777433	8217638	\N	\N	1
777435	8217638	\N	\N	1
777437	8217638	\N	\N	1
777439	8217638	\N	\N	1
777441	8217638	\N	\N	1
777443	8217638	0.003	0.003	1
777445	8217638	\N	\N	1
777447	8217638	\N	\N	1
777449	8217638	\N	\N	1
777451	8217638	\N	\N	1
777453	8217638	\N	\N	1
777455	8217638	\N	\N	1
777457	8217638	\N	\N	1
777459	8217638	\N	\N	1
777461	8217638	\N	\N	1
777463	8217638	\N	\N	1
777465	8217638	\N	\N	1
777467	8217638	\N	\N	1
777469	8217638	\N	\N	1
777471	8217638	\N	\N	1
777473	8217638	\N	\N	1
777475	8217638	\N	\N	1
777477	8217638	\N	\N	1
777479	8217638	\N	\N	1
777481	8217638	\N	\N	1
777483	8217638	\N	\N	1
777485	8217638	\N	\N	1
777487	8217638	\N	\N	1
777489	8217638	\N	\N	1
777491	8217638	\N	\N	1
777493	8217638	\N	\N	1
777495	8217638	\N	\N	1
777425	8217639	0.043	0.043	1
777427	8217639	0	0.0	1
777429	8217639	0	0.0	1
777431	8217639	0.086	0.086	1
777433	8217639	0.328	0.328	1
777435	8217639	0	0.0	1
777423	8217636	1	1.0	2
777423	8217638	0.997	0.997	2
777437	8217639	0	0.0	1
777439	8217639	0	0.0	1
777441	8217639	\N	\N	1
777443	8217639	\N	\N	1
777445	8217639	\N	\N	1
777447	8217639	\N	\N	1
777449	8217639	\N	\N	1
777451	8217639	\N	\N	1
777453	8217639	0.071	0.071	1
777455	8217639	0.029	0.029	1
777457	8217639	0	0.0	1
777459	8217639	0	0.0	1
777461	8217639	0	0.0	1
777463	8217639	0.011	0.011	1
777465	8217639	\N	\N	1
777467	8217639	\N	\N	1
777469	8217639	\N	\N	1
777471	8217639	\N	\N	1
777473	8217639	\N	\N	1
777475	8217639	\N	\N	1
777477	8217639	\N	\N	1
777479	8217639	\N	\N	1
777481	8217639	\N	\N	1
777483	8217639	\N	\N	1
777485	8217639	\N	\N	1
777487	8217639	\N	\N	1
777489	8217639	\N	\N	1
777491	8217639	\N	\N	1
777493	8217639	\N	\N	1
777495	8217639	\N	\N	1
777425	8217640	0	0.0	1
777427	8217640	\N	\N	1
777429	8217640	0.037	0.037	1
777431	8217640	0	0.0	1
777433	8217640	0.259	0.259	1
777435	8217640	0	0.0	1
777437	8217640	\N	\N	1
777439	8217640	0.167	0.167	1
777441	8217640	\N	\N	1
777443	8217640	\N	\N	1
777445	8217640	\N	\N	1
777447	8217640	\N	\N	1
777449	8217640	\N	\N	1
777451	8217640	\N	\N	1
777453	8217640	\N	\N	1
777455	8217640	0.037	0.037	1
777457	8217640	\N	\N	1
777459	8217640	\N	\N	1
777461	8217640	\N	\N	1
777463	8217640	\N	\N	1
777465	8217640	\N	\N	1
777467	8217640	\N	\N	1
777469	8217640	\N	\N	1
777471	8217640	\N	\N	1
777473	8217640	\N	\N	1
777475	8217640	\N	\N	1
777477	8217640	\N	\N	1
777479	8217640	\N	\N	1
777481	8217640	\N	\N	1
777483	8217640	\N	\N	1
777485	8217640	\N	\N	1
777487	8217640	\N	\N	1
777489	8217640	\N	\N	1
777491	8217640	\N	\N	1
777493	8217640	\N	\N	1
777495	8217640	\N	\N	1
777425	8217641	\N	\N	1
777427	8217641	0.008	0.008	1
777429	8217641	\N	\N	1
777431	8217641	\N	\N	1
777433	8217641	\N	\N	1
777435	8217641	\N	\N	1
777437	8217641	\N	\N	1
777439	8217641	\N	\N	1
777441	8217641	\N	\N	1
777443	8217641	0	0.0	1
777445	8217641	0	0.0	1
777447	8217641	\N	\N	1
777449	8217641	0	0.0	1
777451	8217641	0	0.0	1
777453	8217641	\N	\N	1
777455	8217641	\N	\N	1
777457	8217641	\N	\N	1
777459	8217641	\N	\N	1
777461	8217641	\N	\N	1
777463	8217641	\N	\N	1
777465	8217641	0	0.0	1
777467	8217641	\N	\N	1
777469	8217641	\N	\N	1
777471	8217641	\N	\N	1
777473	8217641	\N	\N	1
777475	8217641	\N	\N	1
777477	8217641	\N	\N	1
777479	8217641	\N	\N	1
777481	8217641	\N	\N	1
777483	8217641	\N	\N	1
777485	8217641	\N	\N	1
777487	8217641	\N	\N	1
777489	8217641	\N	\N	1
777491	8217641	\N	\N	1
777493	8217641	\N	\N	1
777495	8217641	\N	\N	1
777425	8217642	\N	\N	1
777427	8217642	0	0.0	1
777429	8217642	\N	\N	1
777431	8217642	\N	\N	1
777433	8217642	\N	\N	1
777435	8217642	\N	\N	1
777437	8217642	\N	\N	1
777439	8217642	\N	\N	1
777441	8217642	\N	\N	1
777443	8217642	0	0.0	1
777445	8217642	0	0.0	1
777447	8217642	\N	\N	1
777449	8217642	0	0.0	1
777451	8217642	0	0.0	1
777453	8217642	\N	\N	1
777455	8217642	\N	\N	1
777457	8217642	\N	\N	1
777459	8217642	\N	\N	1
777461	8217642	\N	\N	1
777463	8217642	\N	\N	1
777465	8217642	0.005	0.005	1
777467	8217642	\N	\N	1
777469	8217642	\N	\N	1
777471	8217642	\N	\N	1
777473	8217642	\N	\N	1
777475	8217642	\N	\N	1
777477	8217642	\N	\N	1
777479	8217642	\N	\N	1
777481	8217642	\N	\N	1
777483	8217642	\N	\N	1
777485	8217642	\N	\N	1
777487	8217642	\N	\N	1
777489	8217642	\N	\N	1
777491	8217642	\N	\N	1
777493	8217642	\N	\N	1
777495	8217642	\N	\N	1
778235	8218957	\N	\N	1
777425	8217643	\N	\N	1
777427	8217643	0	0.0	1
777429	8217643	\N	\N	1
777431	8217643	\N	\N	1
777433	8217643	\N	\N	1
777435	8217643	\N	\N	1
777437	8217643	\N	\N	1
777439	8217643	\N	\N	1
777441	8217643	\N	\N	1
777443	8217643	0	0.0	1
777445	8217643	0	0.0	1
777447	8217643	\N	\N	1
777449	8217643	0	0.0	1
777451	8217643	0	0.0	1
777453	8217643	\N	\N	1
777455	8217643	\N	\N	1
777457	8217643	\N	\N	1
777459	8217643	\N	\N	1
777461	8217643	\N	\N	1
777463	8217643	\N	\N	1
777465	8217643	0	0.0	1
777467	8217643	\N	\N	1
777469	8217643	\N	\N	1
777471	8217643	\N	\N	1
777473	8217643	\N	\N	1
777475	8217643	\N	\N	1
777477	8217643	\N	\N	1
777479	8217643	\N	\N	1
777481	8217643	\N	\N	1
777483	8217643	\N	\N	1
777485	8217643	\N	\N	1
777487	8217643	\N	\N	1
777489	8217643	\N	\N	1
777491	8217643	\N	\N	1
777493	8217643	\N	\N	1
777495	8217643	\N	\N	1
777423	8217641	0.992	0.992	2
777423	8217640	0.5	0.5	2
777423	8217642	0.995	0.995	2
777425	8217644	\N	\N	1
777427	8217644	0	0.0	1
777429	8217644	\N	\N	1
777431	8217644	\N	\N	1
777433	8217644	\N	\N	1
777435	8217644	\N	\N	1
777437	8217644	\N	\N	1
777439	8217644	\N	\N	1
777441	8217644	\N	\N	1
777443	8217644	0.006	0.006	1
777445	8217644	0	0.0	1
777447	8217644	\N	\N	1
777449	8217644	0	0.0	1
777451	8217644	0	0.0	1
777453	8217644	\N	\N	1
777455	8217644	\N	\N	1
777457	8217644	\N	\N	1
777459	8217644	\N	\N	1
777461	8217644	\N	\N	1
777463	8217644	\N	\N	1
777465	8217644	0	0.0	1
777467	8217644	\N	\N	1
777469	8217644	\N	\N	1
777471	8217644	\N	\N	1
777473	8217644	\N	\N	1
777475	8217644	\N	\N	1
777477	8217644	\N	\N	1
777479	8217644	\N	\N	1
777481	8217644	\N	\N	1
777483	8217644	\N	\N	1
777485	8217644	\N	\N	1
777487	8217644	\N	\N	1
777489	8217644	\N	\N	1
777491	8217644	\N	\N	1
777493	8217644	\N	\N	1
777495	8217644	\N	\N	1
777425	8217645	\N	\N	1
777427	8217645	0.005	0.005	1
777429	8217645	\N	\N	1
777431	8217645	\N	\N	1
777433	8217645	\N	\N	1
777435	8217645	\N	\N	1
777437	8217645	\N	\N	1
777439	8217645	\N	\N	1
777441	8217645	\N	\N	1
777443	8217645	0	0.0	1
777445	8217645	0	0.0	1
777447	8217645	\N	\N	1
777449	8217645	0	0.0	1
777451	8217645	0	0.0	1
777453	8217645	\N	\N	1
777455	8217645	\N	\N	1
777457	8217645	\N	\N	1
777459	8217645	\N	\N	1
777461	8217645	\N	\N	1
777463	8217645	\N	\N	1
777465	8217645	0	0.0	1
777467	8217645	\N	\N	1
777469	8217645	\N	\N	1
777471	8217645	\N	\N	1
777473	8217645	\N	\N	1
777475	8217645	\N	\N	1
777477	8217645	\N	\N	1
777479	8217645	\N	\N	1
777481	8217645	\N	\N	1
777483	8217645	\N	\N	1
777485	8217645	\N	\N	1
777487	8217645	\N	\N	1
777489	8217645	\N	\N	1
777491	8217645	\N	\N	1
777493	8217645	\N	\N	1
777495	8217645	\N	\N	1
777425	8217646	\N	\N	1
777427	8217646	0.005	0.005	1
777429	8217646	\N	\N	1
777431	8217646	\N	\N	1
777433	8217646	\N	\N	1
777435	8217646	\N	\N	1
777437	8217646	\N	\N	1
777439	8217646	\N	\N	1
777441	8217646	\N	\N	1
777443	8217646	0	0.0	1
777445	8217646	0	0.0	1
777447	8217646	\N	\N	1
777449	8217646	0	0.0	1
777451	8217646	0	0.0	1
777453	8217646	\N	\N	1
777455	8217646	\N	\N	1
777457	8217646	\N	\N	1
777459	8217646	\N	\N	1
777461	8217646	\N	\N	1
777463	8217646	\N	\N	1
777465	8217646	0	0.0	1
777467	8217646	\N	\N	1
777469	8217646	\N	\N	1
777471	8217646	\N	\N	1
777473	8217646	\N	\N	1
777475	8217646	\N	\N	1
777477	8217646	\N	\N	1
777479	8217646	\N	\N	1
777481	8217646	\N	\N	1
777483	8217646	\N	\N	1
777485	8217646	\N	\N	1
777487	8217646	\N	\N	1
777489	8217646	\N	\N	1
777491	8217646	\N	\N	1
777493	8217646	\N	\N	1
777495	8217646	\N	\N	1
777425	8217647	\N	\N	1
777427	8217647	0.002456	0.002456	1
777429	8217647	\N	\N	1
777431	8217647	\N	\N	1
777433	8217647	\N	\N	1
777435	8217647	\N	\N	1
777437	8217647	\N	\N	1
777439	8217647	\N	\N	1
777441	8217647	\N	\N	1
777443	8217647	0.002242	0.002242	1
777445	8217647	0	0.0	1
777447	8217647	\N	\N	1
777449	8217647	0.002861	0.002861	1
777451	8217647	0.00009746	9.746E-5	1
777453	8217647	\N	\N	1
777455	8217647	\N	\N	1
777457	8217647	\N	\N	1
777459	8217647	\N	\N	1
777461	8217647	0	0.0	1
777463	8217647	\N	\N	1
777465	8217647	0	0.0	1
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777573	8218031	\N	\N	1
777575	8218031	\N	\N	1
777577	8218031	\N	\N	1
777579	8218031	\N	\N	1
777581	8218031	\N	\N	1
777583	8218031	\N	\N	1
777585	8218031	\N	\N	1
777587	8218031	\N	\N	1
777589	8218031	\N	\N	1
777591	8218031	\N	\N	1
777593	8218031	\N	\N	1
777595	8218031	\N	\N	1
777597	8218031	\N	\N	1
777599	8218031	\N	\N	1
777531	8218031	\N	\N	1
777601	8218031	\N	\N	1
777535	8218032	0.1116	0.1116	1
777537	8218032	\N	\N	1
777539	8218032	\N	\N	1
777541	8218032	\N	\N	1
777543	8218032	\N	\N	1
777545	8218032	\N	\N	1
777547	8218032	\N	\N	1
777549	8218032	\N	\N	1
777551	8218032	\N	\N	1
777553	8218032	\N	\N	1
777555	8218032	\N	\N	1
777557	8218032	\N	\N	1
777559	8218032	\N	\N	1
777561	8218032	\N	\N	1
777563	8218032	\N	\N	1
777565	8218032	\N	\N	1
777567	8218032	\N	\N	1
777569	8218032	\N	\N	1
777571	8218032	\N	\N	1
777573	8218032	\N	\N	1
777575	8218032	\N	\N	1
777577	8218032	\N	\N	1
777579	8218032	\N	\N	1
777581	8218032	\N	\N	1
777583	8218032	\N	\N	1
777585	8218032	\N	\N	1
777587	8218032	\N	\N	1
777589	8218032	\N	\N	1
777591	8218032	\N	\N	1
777593	8218032	\N	\N	1
777595	8218032	\N	\N	1
777597	8218032	\N	\N	1
777599	8218032	\N	\N	1
777531	8218032	\N	\N	1
777601	8218032	\N	\N	1
777535	8218033	0.1312	0.1312	1
777537	8218033	\N	\N	1
777539	8218033	\N	\N	1
777541	8218033	\N	\N	1
777543	8218033	\N	\N	1
777545	8218033	\N	\N	1
777547	8218033	\N	\N	1
777549	8218033	\N	\N	1
777551	8218033	\N	\N	1
777553	8218033	\N	\N	1
777555	8218033	\N	\N	1
777557	8218033	\N	\N	1
777559	8218033	\N	\N	1
777561	8218033	\N	\N	1
777563	8218033	\N	\N	1
777565	8218033	0.1989	0.1989	1
777567	8218033	\N	\N	1
777569	8218033	\N	\N	1
777571	8218033	\N	\N	1
777573	8218033	\N	\N	1
777575	8218033	\N	\N	1
777577	8218033	\N	\N	1
777579	8218033	\N	\N	1
777581	8218033	\N	\N	1
777583	8218033	\N	\N	1
777585	8218033	\N	\N	1
777587	8218033	\N	\N	1
777589	8218033	\N	\N	1
777591	8218033	\N	\N	1
777593	8218033	\N	\N	1
777595	8218033	\N	\N	1
777597	8218033	\N	\N	1
777599	8218033	\N	\N	1
777531	8218033	\N	\N	1
777601	8218033	\N	\N	1
777535	8218034	0.1474	0.1474	1
777537	8218034	\N	\N	1
777539	8218034	\N	\N	1
777541	8218034	\N	\N	1
777543	8218034	\N	\N	1
777545	8218034	\N	\N	1
777547	8218034	\N	\N	1
777549	8218034	\N	\N	1
777551	8218034	\N	\N	1
777553	8218034	\N	\N	1
777555	8218034	\N	\N	1
777557	8218034	\N	\N	1
777559	8218034	\N	\N	1
777561	8218034	\N	\N	1
777563	8218034	\N	\N	1
777565	8218034	0.1987	0.1987	1
777567	8218034	\N	\N	1
777569	8218034	\N	\N	1
777571	8218034	\N	\N	1
777573	8218034	\N	\N	1
777575	8218034	\N	\N	1
777577	8218034	\N	\N	1
777579	8218034	\N	\N	1
777581	8218034	\N	\N	1
777583	8218034	\N	\N	1
777585	8218034	\N	\N	1
777587	8218034	\N	\N	1
777589	8218034	\N	\N	1
777591	8218034	\N	\N	1
777593	8218034	\N	\N	1
777595	8218034	\N	\N	1
777597	8218034	\N	\N	1
777599	8218034	\N	\N	1
777531	8218034	\N	\N	1
777601	8218034	\N	\N	1
777535	8218035	0.2727	0.2727	1
777537	8218035	0	0.0	1
777539	8218035	0.005	0.0050	1
777541	8218035	\N	\N	1
777543	8218035	0.0101	0.0101	1
777545	8218035	\N	\N	1
777547	8218035	\N	\N	1
777549	8218035	\N	\N	1
777551	8218035	\N	\N	1
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777557	8218035	\N	\N	1
777559	8218035	\N	\N	1
777561	8218035	\N	\N	1
777533	8218032	0.8884	0.8884	2
777533	8218034	0.6539	0.6539	2
777533	8218031	0.859	0.85899997	2
777563	8218035	\N	\N	1
777565	8218035	0.1818	0.1818	1
777567	8218035	\N	\N	1
777569	8218035	\N	\N	1
777571	8218035	\N	\N	1
777573	8218035	\N	\N	1
777575	8218035	\N	\N	1
777577	8218035	\N	\N	1
777579	8218035	\N	\N	1
777581	8218035	\N	\N	1
777583	8218035	\N	\N	1
777585	8218035	\N	\N	1
777587	8218035	\N	\N	1
