-- Data for Name: gene; Type: TABLE DATA; Schema: cpic; Owner: -
--

COPY cpic.gene (symbol, chr, genesequenceid, proteinsequenceid, chromosequenceid, mrnasequenceid, hgncid, ncbiid, ensemblid, clinpgxid, frequencymethods, lookupmethod, version, notesondiplotype, url, functionmethods, notesonallelenaming, includephenotypefrequencies, includediplotypefrequencies) FROM stdin;
F5	chr1	NG_011806	NP_000121	\N	\N	HGNC:3542	2153	ENSG00000198734	PA159	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
CYB5R3	chr22	NG_012194	NP_000389	\N	\N	HGNC:2873	1727	ENSG00000100243	PA27331	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
CHRNA3	chr15	NG_016143	NP_000734	\N	\N	HGNC:1957	1136	ENSG00000080644	PA113	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
HMGCR	chr5	NG_011449	NP_000850	\N	\N	HGNC:5006	3156	ENSG00000113161	PA189	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
MTRR	chr5	NG_008856	NP_002445	\N	\N	HGNC:7473	4552	ENSG00000124275	PA31277	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
LPA	chr6	NG_016147	NP_005568	\N	\N	HGNC:6667	4018	ENSG00000198670	PA30432	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
ADRA2C	\N	\N	\N	\N	\N	HGNC:283	152	ENSG00000184160	PA37	\N	PHENOTYPE	27	\N	https://cpicpgx.org/gene/adra2c/	\N	\N	t	t
NAT1	chr8	NG_012245	NP_000653	\N	\N	HGNC:7645	9	ENSG00000171428	PA17	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
CPS1	chr2	NG_008285	NP_001866	\N	\N	HGNC:2323	1373	ENSG00000021826	PA26840	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
EGF	chr4	NG_011441	NP_001954	\N	\N	HGNC:3229	1950	ENSG00000138798	PA27664	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
CRHR1	chr17	NG_009902	NP_004373	\N	\N	HGNC:2357	1394	ENSG00000120088	PA26874	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
ACE	chr17	NG_011648	NP_000780	\N	\N	HGNC:2707	1636	ENSG00000159640	PA139	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
CALU	chr7	\N	NP_001210	\N	\N	HGNC:1458	813	ENSG00000128595	PA26047	\N	PHENOTYPE	115	\N	\N	\N	\N	t	t
ITPA	chr20	NG_012093	NP_258412	\N	\N	HGNC:6176	3704	ENSG00000125877	PA29973	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
MC4R	chr18	NG_016441	NP_005903	\N	\N	HGNC:6932	4160	ENSG00000166603	PA30676	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
COQ2	chr4	NG_015825	NP_056512	\N	\N	HGNC:25223	27235	ENSG00000173085	PA142672084	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
DYNC2H1	chr11	NG_016423	NP_001368	\N	\N	HGNC:2962	79659	ENSG00000187240	PA27433	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
GNB3	chr12	NG_009100	NP_002066	\N	\N	HGNC:4400	2784	ENSG00000111664	PA176	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
SEMA3C	chr7	\N	NP_006370	\N	\N	HGNC:10725	10512	ENSG00000075223	PA35647	\N	PHENOTYPE	4	\N	\N	\N	\N	t	t
KIF6	chr6	\N	NP_659464	\N	\N	HGNC:21202	221458	ENSG00000164627	PA134920075	\N	PHENOTYPE	4	\N	\N	\N	\N	t	t
CCHCR1	chr6	\N	NP_061925	\N	\N	HGNC:13930	54535	ENSG00000204536	PA134942738	\N	PHENOTYPE	4	\N	\N	\N	\N	t	t
FCGR3A	chr1	NG_009066	NP_000560	\N	\N	HGNC:3619	2214	ENSG00000203747	PA28065	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
NAGS	chr17	NG_008106	NP_694551	\N	\N	HGNC:17996	162417	ENSG00000161653	PA134968729	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
LDLR	chr19	NG_009060	NP_000518	\N	\N	HGNC:6547	3949	ENSG00000130164	PA227	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
ASL	chr7	NG_009288	NP_000039	\N	\N	HGNC:746	435	ENSG00000126522	PA25046	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
HPRT1	chrX	NG_012329	NP_000185	\N	\N	HGNC:5157	3251	ENSG00000165704	PA29427	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
ANKK1	chr11	NG_012976	NP_848605	\N	\N	HGNC:21027	255239	ENSG00000170209	PA134872551	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
XPC	chr3	NG_011763	NP_004619	\N	\N	HGNC:12816	7508	ENSG00000154767	PA37413	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
ADRB2	chr5	NG_016421	NP_000015	\N	\N	HGNC:286	154	ENSG00000169252	PA39	\N	PHENOTYPE	4	\N	https://cpicpgx.org/gene/adrb2/	\N	\N	t	t
FKBP5	chr6	NG_012645	NP_004108	\N	\N	HGNC:3721	2289	ENSG00000096060	PA28162	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
TXNRD2	chr22	NG_011835	NP_006431	\N	\N	HGNC:18155	10587	ENSG00000184470	PA38302	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
GBA	chr1	NG_009783	NP_000148	\N	\N	HGNC:4177	2629	ENSG00000177628	PA28591	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
HLA-DRB1	chr6	NG_002392	NP_002115	\N	\N	HGNC:4948	3123	ENSG00000196126	PA35072	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
CETP	chr16	NG_008952	NP_000069	\N	\N	HGNC:1869	1071	ENSG00000087237	PA108	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
UGT1A4	chr2	NG_002601	NP_009051	\N	\N	HGNC:12536	54657	ENSG00000244474	PA37179	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
TP53	chr17	NG_017013	NP_000537	\N	\N	HGNC:11998	7157	ENSG00000141510	PA36679	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
PRKCA	chr17	NG_012206	NP_002728	\N	\N	HGNC:9393	5578	ENSG00000154229	PA33759	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
HTR2C	chrX	NG_012082	NP_000859	\N	\N	HGNC:5295	3358	ENSG00000147246	PA194	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
OTC	chrX	NG_008471	NP_000522	\N	\N	HGNC:8512	5009	ENSG00000036473	PA32840	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
CES1	chr16	NG_012057	NP_001257	\N	\N	HGNC:1863	1066	ENSG00000198848	PA107	\N	PHENOTYPE	114	\N	\N	\N	\N	t	t
ERCC1	chr19	NG_015839	NP_001974	\N	\N	HGNC:3433	2067	ENSG00000012061	PA155	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
POLG	chr15	NG_008218	NP_002684	\N	\N	HGNC:9179	5428	ENSG00000140521	PA33500	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
ASS1	chr9	NG_011542	NP_000041	\N	\N	HGNC:758	445	ENSG00000130707	PA162376926	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
DRD2	chr11	NG_008841	NP_000786	\N	\N	HGNC:3023	1813	ENSG00000149295	PA27478	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
ATIC	chr2	NG_013002	NP_004035	\N	\N	HGNC:794	471	ENSG00000138363	PA25094	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
APOE	chr19	NG_007084	NP_000032	\N	\N	HGNC:613	348	ENSG00000130203	PA55	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
GSTM1	chr1	NG_009246	NP_000552	\N	\N	HGNC:4632	2944	ENSG00000134184	PA182	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
CYB5R1	chr1	\N	NP_057327	\N	\N	HGNC:13397	51706	ENSG00000159348	PA134979668	\N	PHENOTYPE	4	\N	\N	\N	\N	t	t
SLC28A3	chr9	\N	NP_071410	\N	\N	HGNC:16484	64078	ENSG00000197506	PA426	\N	PHENOTYPE	4	\N	\N	\N	\N	t	t
FDPS	chr1	\N	NP_001995	\N	\N	HGNC:3631	2224	ENSG00000160752	PA28075	\N	PHENOTYPE	4	\N	\N	\N	\N	t	t
PTGFR	chr1	\N	NP_000950	\N	\N	HGNC:9600	5737	ENSG00000122420	PA290	\N	PHENOTYPE	4	\N	\N	\N	\N	t	t
KCNIP4	chr4	\N	NP_671711	\N	\N	HGNC:30083	80333	ENSG00000185774	PA134893552	\N	PHENOTYPE	4	\N	\N	\N	\N	t	t
TCF7L2	chr10	NG_012631	NP_110383	\N	\N	HGNC:11641	6934	ENSG00000148737	PA36394	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
HLA-DQA1	chr6	\N	NP_002113	\N	\N	HGNC:4942	3117	ENSG00000196735	PA35066	\N	PHENOTYPE	4	\N	\N	\N	\N	t	t
ADD1	chr4	NG_012037	NP_001110	\N	\N	HGNC:243	118	ENSG00000087274	PA31	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
ABCC4	chr13	\N	NP_005836	\N	\N	HGNC:55	10257	ENSG00000125257	PA397	\N	PHENOTYPE	4	\N	\N	\N	\N	t	t
ABL2	chr1	\N	NP_005149	\N	\N	HGNC:77	27	ENSG00000143322	PA24414	\N	PHENOTYPE	4	\N	\N	\N	\N	t	t
UGT2B15	chr4	\N	NP_001067	\N	\N	HGNC:12546	7366	ENSG00000196620	PA37188	\N	PHENOTYPE	4	\N	\N	\N	\N	t	t
YEATS4	chr12	\N	NP_006521	\N	\N	HGNC:24859	8089	ENSG00000127337	PA134992686	\N	PHENOTYPE	4	\N	\N	\N	\N	t	t
TANC1	chr2	\N	NP_203752	\N	\N	HGNC:29364	85461	ENSG00000115183	PA142670838	\N	PHENOTYPE	4	\N	\N	\N	\N	t	t
TMEM43	chr3	NG_008975	NP_077310	\N	\N	HGNC:28472	79188	ENSG00000170876	PA134871907	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
CRHR2	chr7	\N	NP_001874	\N	\N	HGNC:2358	1395	ENSG00000106113	PA26875	\N	PHENOTYPE	4	\N	\N	\N	\N	t	t
SOD2	chr6	NG_008729	NP_000627	\N	\N	HGNC:11180	6648	ENSG00000112096	PA36017	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
SERPINC1	chr1	NG_012462	NP_000479	\N	\N	HGNC:775	462	ENSG00000117601	PA35026	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
TNF	chr6	NG_007462	NP_000585	\N	\N	HGNC:11892	7124	ENSG00000232810	PA435	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
C11orf65	chr11	\N	NP_689800	\N	\N	HGNC:28519	160140	ENSG00000166323	PA144596484	\N	PHENOTYPE	4	\N	\N	\N	\N	t	t
HAS3	chr16	\N	NP_005320	\N	\N	HGNC:4820	3038	ENSG00000103044	PA29196	\N	PHENOTYPE	4	\N	\N	\N	\N	t	t
CYB5R2	chr11	\N	NP_057313	\N	\N	HGNC:24376	51700	ENSG00000166394	PA142672060	\N	PHENOTYPE	4	\N	\N	\N	\N	t	t
SLC47A2	chr17	\N	NP_001093116	\N	\N	HGNC:26439	146802	ENSG00000180638	PA162403847	\N	PHENOTYPE	4	\N	\N	\N	\N	t	t
CBR3	chr21	\N	NP_001227	\N	\N	HGNC:1549	874	ENSG00000159231	PA26122	\N	PHENOTYPE	4	\N	\N	\N	\N	t	t
NT5C2	chr10	\N	NP_036361	\N	\N	HGNC:8022	22978	ENSG00000076685	PA31801	\N	PHENOTYPE	4	\N	\N	\N	\N	t	t
CYB5R4	chr6	\N	NP_057314	\N	\N	HGNC:20147	51167	ENSG00000065615	PA134904907	\N	PHENOTYPE	4	\N	\N	\N	\N	t	t
C8orf34	chr8	\N	NP_443190	\N	\N	HGNC:30905	116328	ENSG00000165084	PA142672353	\N	PHENOTYPE	4	\N	\N	\N	\N	t	t
ADRB1	\N	\N	\N	\N	\N	HGNC:285	153	ENSG00000043591	PA38	\N	PHENOTYPE	113	\N	https://cpicpgx.org/gene/adrb1/	\N	\N	t	t
ADORA2A	chr22	\N	NP_000666	\N	\N	HGNC:263	135	ENSG00000128271	PA24584	\N	PHENOTYPE	4	\N	\N	\N	\N	t	t
PTGS1	chr9	\N	NP_000953	\N	\N	HGNC:9604	5742	ENSG00000095303	PA24346	\N	PHENOTYPE	115	\N	\N	\N	\N	t	t
NAT2	chr8	NG_012246.1	NP_000006.2	NC_000008.11	NM_001042351.2	HGNC:7646	10	ENSG00000156006	PA18	\N	PHENOTYPE	140	\N	\N	\N	Common name	t	t
CYP2A7P1	chr19	NG_000008	\N	\N	\N	HGNC:2612	1550	ENSG00000213908	PA27103	\N	PHENOTYPE	115	\N	\N	\N	\N	t	t
FLOT1	chr6	\N	NP_005794	\N	\N	HGNC:3757	10211	ENSG00000137312	PA28175	\N	PHENOTYPE	115	\N	\N	\N	\N	t	t
GRIK4	chr11	\N	NP_055434	\N	\N	HGNC:4582	2900	ENSG00000149403	PA28976	\N	PHENOTYPE	115	\N	\N	\N	\N	t	t
NEDD4L	chr18	\N	NP_056092	\N	\N	HGNC:7728	23327	ENSG00000049759	PA31534	\N	PHENOTYPE	4	\N	\N	\N	\N	t	t
GRK4	\N	\N	\N	\N	\N	HGNC:4543	2868	ENSG00000125388	PA28941	\N	PHENOTYPE	27	\N	https://cpicpgx.org/gene/grk4/	\N	\N	t	t
GRK5	\N	\N	\N	\N	\N	HGNC:4544	2869	ENSG00000198873	PA180	\N	PHENOTYPE	113	\N	https://cpicpgx.org/gene/grk5/	\N	\N	t	t
HLA-C	chr6	NG_002397	NP_002108	\N	\N	HGNC:4933	3107	ENSG00000204525	PA35057	\N	PHENOTYPE	114	\N	\N	\N	\N	t	t
HLA-DPB1	chr6	\N	NP_002112	\N	\N	HGNC:4940	3115	ENSG00000223865	PA35064	\N	PHENOTYPE	115	\N	\N	\N	\N	t	t
HTR1A	chr5	\N	NP_000515	\N	\N	HGNC:5286	3350	ENSG00000178394	PA192	\N	PHENOTYPE	115	\N	\N	\N	\N	t	t
IFNL4	chr19	\N	\N	\N	\N	HGNC:44480	101180976	ENSG00000272395	PA166049147	\N	PHENOTYPE	117	\N	https://cpicpgx.org/gene/ifnl/	\N	\N	t	t
LTC4S	chr5	\N	NP_665874	\N	\N	HGNC:6719	4056	ENSG00000213316	PA235	\N	PHENOTYPE	115	\N	\N	\N	\N	t	t
OPRM1	chr6	NG_021208	NP_000905	\N	\N	HGNC:8156	4988	ENSG00000112038	PA31945	\N	PHENOTYPE	108	\N	https://cpicpgx.org/gene/oprm1/	\N	\N	t	t
XRCC1	chr19	\N	NP_006288	\N	\N	HGNC:12828	7515	ENSG00000073050	PA369	\N	PHENOTYPE	4	\N	\N	\N	\N	t	t
COL22A1	chr8	\N	NP_690848	\N	\N	HGNC:22989	169044	ENSG00000169436	PA134914705	\N	PHENOTYPE	4	\N	\N	\N	\N	t	t
DPYD	chr1	NG_008807.2	NP_000101.2	NC_000001.11	NM_000110.4	HGNC:3012	282617	ENSG00000188641	PA145	Methods:\nThe DPYD frequency table was created using data from ExAC (http://exac.broadinstitute.org/) and the 1000 Genomes project (http://www.ensembl.org/Homo_sapiens/Info/Index).\nThe average allele frequencies by race were calculated by taking the number with the variant in all studies divided by the total number of individuals tested for the variant in all studies.\nAll nucleotide changes are according to reference sequence NM_000110.3 and all protein changes are according to reference sequence NP_000101.2\nCaveats\nIf 1000 Genomes and/or ExAC did not return any frequency data for a given variant, cells were left blank\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details can be found at https://www.pharmgkb.org/page/biogeographicalGroups. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.\n\n\n\n\n\n\n\n	ACTIVITY_SCORE	447	The DPYD phenotype is assigned using a gene activity score (DPYD-AS; based on the DPYD Allele Functionality Table), calculated as the sum of the two DPYD variants with the lowest variant activity value. Briefly, carriers of two no function variants (DPYD-AS: 0) OR one decreased function variant (DPD-AS: 0.5) are classified as DPYD poor metabolizers; carriers of two decreased function variants OR carriers of only one no function variant (DPYD-AS: 1) OR carriers of only one decreased function variant (DPYD-AS: 1.5) are considered DPYD intermediate metabolizers , and those with only normal function variants are classified as DPYD normal metabolizers (DPYD-AS: 2). If two decreased/no function variants are present, each decreased/no function variant is considered to be on a different gene copy. Irrespective of the presence of decreased/no function variants, patients may carry multiple normal function variants. As an individual only carries a maximum of two fully functional DPYD copies, common normal function variants may be located on the same gene copy as other normal function variants or decreased/no function variants.	https://cpicpgx.org/gene/dpyd/	\N	Legacy Name/Class	f	f
HLA-A	chr6	NG_002398	NP_002107	\N	\N	HGNC:4931	3105	ENSG00000206503	PA35055	Methods\n\nThe allele frequency table was made by searching the PubMed® database (1995 to September 2019). The following criteria were used for HLA-A: (HLA-A) AND (allele OR frequency). In addition, reports were also identified from citations by others or review articles. Studies were considered for inclusion in the HLA-A frequency table if: (1) the ethnicity of the population was clearly indicated, (2) either allele frequencies or genotype frequencies were reported, (3) the method by which the genes were genotyped was indicated, (4) the sample population consisted of at least 50 individuals with a few exceptions (e.g., smaller cohorts that were part of larger studies) and (5) the study represented an original publication (no reviews or meta-analyses). Allele frequencies reported in phase 3 1000 Genomes (http://browser.1000genomes.org/index.html) and from allelefrequencies.net (https://www.allelefrequencies.net) were also included .\nCaveats to estimated allele frequencies:\n\nSampling. Allele frequencies collected by CPIC for the supplemental tables are based on published literature reports which typically study small groups of people based on a geographic location (e.g. Malaysia, Berlin, Cairo). Almost no studies use genetic markers to estimate ancestry. Manuscripts are often focused on a specific phenotype (e.g. disease) or study only individuals taking a particular drug. Such samples would not be considered a random sample of the general population. Another consideration is that sample size is important, and PGx studies are typically not large. The frequencies collected from these studies are then used to estimate general estimates of entire ethnic population allele frequencies. Therefore, frequencies from larger groups of subjects and frequencies averaged from many sample populations probably result in better estimates.\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details, including the definitions of each group, can be found at https://www.pharmgkb.org/page/biogeographicalGroups. We strongly recommend that users use either the publication or the PharmGKB link provided to familiarize themselves with the grouping system before using these allele frequencies. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.	ALLELE_STATUS	224	\N	https://cpicpgx.org/gene/hla/	\N	\N	f	f
NUDT15	chr13	NG_047021.1	NP_060753.1	NC_000013.11	NM_001042351.2	HGNC:23063	55270	ENSG00000136159	PA134963132	The allele frequency table was made by searching the PubMed® database (no start date to 1/2018). Allele frequencies reported in the gnomAD browser (http://gnomad.broadinstitute.org/ - exomes and genomes) and ensembl (grch37.ensembl.org - exomes or genomes) were also included. URLs are included in the "PMID" column.\n\nDiplotype and phenotype frequencies were estimated using the equation describing Hardy Weinberg equilibrium based on reported allele frequencies.\n\nCaveats to estimated allele, diplotype and phenotype frequencies:\n\nSampling. Allele frequencies collected by CPIC for the supplemental tables are based on published literature reports which typically study small groups of people based on a geographic location (e.g. Malaysia, Berlin, Cairo). Almost no studies use genetic markers to estimate ancestry. Manuscripts are often focused on a specific phenotype (e.g. disease) or study only individuals taking a particular drug. Such samples would not be considered a random sample of the general population. Another consideration is that sample size is important, and PGx studies are typically not large. The frequencies collected from these studies are then used to estimate general estimates of entire ethnic population allele frequencies. Therefore, frequencies from larger groups of subjects and frequencies averaged from many sample populations probably result in better estimates.\n\nEstimation of *1 frequency. In general, there are no population studies that test for all known variant alleles. Because *1 is not genotyped directly in many studies, all alleles that are negative for a sequence variation are defaulted to a *1 assignment. The inferred frequency for *1 is estimated as: 100 - (sum of averaged variant allele frequencies). For genes where many alleles are not tested for in any population, and frequency of 'common' alleles is not well documented in many understudied populations (Oceania, South Asian, Latino), the *1 frequency will deviate even more from true values.\n\nDiplotype/Phenotype frequency estimates. Diplotype and phenotype frequencies were estimated using the equation describing Hardy Weinberg equilibrium based on reported allele frequencies. When calculating diplotype frequencies from these allele frequencies, the margin of error is compounded based on the margin of error on each allele in the diplotype. So, the margin of error will necessarily increase for diplotype frequency estimates compared to allele frequency estimates. For allele frequencies with already large margins of error due to small and non-random sampling, the diplotype margin of error could potentially be quite large. On the other hand, for well-studied alleles, the margin of error is likely low.\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details can be found at https://www.pharmgkb.org/page/biogeographicalGroups. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.	PHENOTYPE	438	\N	https://cpicpgx.org/gene/nudt15/	\N	Common name	t	t
RYR1	chr19	NG_008866.1	NP_000531.2	NC_000019.10	NM_000540.2	HGNC:10483	6261	ENSG00000196218	PA34896	Methods\n\nTable includes variants based on an update of the CPIC guideline for potent volatile anesthetic agents and succinylcholine. The guideline update includes the published list of RYR1 variants (supplemental table S2), which are evaluated by the ClinGen malignant hyperthermia susceptibility (MHS) variant curation expert panel and classified for RYR1-related malignant hyperthermia susceptibility based on specified ACMG/AMP criteria (PMID 35849058).\n\ngnomAD v2.1.1 was queried with the variant positions or rsIDs.\ngnomAD population description - PharmGKB biogeographical group mapping:\nAfrican/African American - Sub-Saharan African\nSouth Asian - Central/South Asian\nLatino/Admixed American - Latino\nEast Asian - East Asian\nNon-Finnish European - European\nAshkenazi Jewish - Near Eastern\n\nCaveats to estimated allele, frequencies:\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details, including the definitions of each group, can be found at https://www.pharmgkb.org/page/biogeographicalGroups. We strongly recommend that users use either the publication or the PharmGKB link provided to familiarize themselves with the grouping system before using these allele frequencies. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.	PHENOTYPE	438	\N	https://cpicpgx.org/gene/ryr1/	\N	Common name	f	f
ABCB1	chr7	NG_011513	NP_000918	\N	\N	HGNC:40	5243	ENSG00000085563	PA267	\N	PHENOTYPE	114	\N	\N	\N	\N	t	t
MT-RNR1	chrM	NG_042193.1	NP_000101.2	NC_012920.1	NM_001042351.2	HGNC:7470	4549	ENSG00000211459	PA31274	Methods\n\nThe allele frequency table was made by searching the PubMed® database (1995 to September 2019). The following criteria were used for MT-RNR1: (Mitochondrial AND (A1555G OR C1494T OR T1095C) AND frequency). In addition, reports were also identified from citations by others or review articles. Studies were considered for inclusion in the MT-RNR1 frequency table if: (1) the ethnicity of the population was clearly indicated, (2) the method by which the genes were genotyped was indicated, (3) the sample population consisted of at least 50 individuals with a few exceptions (e.g., smaller cohorts that were part of larger studies) and (4) the study represented an original publication (no reviews or meta-analyses). Homoplasmic allele frequencies reported in gnomAD (https://gnomad.broadinstitute.org/) were also included .\nCaveats to estimated allele, diplotype and phenotype frequencies:\n\nSampling. Allele frequencies collected by CPIC for the supplemental tables are based on published literature reports which typically study small groups of people based on a geographic location (e.g. Malaysia, Berlin, Cairo). Almost no studies use genetic markers to estimate ancestry. Manuscripts are often focused on a specific phenotype (e.g. disease) or study only individuals taking a particular drug. Such samples would not be considered a random sample of the general population. Another consideration is that sample size is important, and PGx studies are typically not large. The frequencies collected from these studies are then used to estimate general estimates of entire ethnic population allele frequencies. Therefore, frequencies from larger groups of subjects and frequencies averaged from many sample populations probably result in better estimates.\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details, including the definitions of each group, can be found at https://www.pharmgkb.org/page/biogeographicalGroups. We strongly recommend that users use either the publication or the PharmGKB link provided to familiarize themselves with the grouping system before using these allele frequencies. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.	PHENOTYPE	402	\N	https://cpicpgx.org/gene/mt-rnr1/	\N	Common name	f	f
CYP4F2	chr19	NG_007971.2	NP_001073.3	NC_000019.10	NM_000069.2	HGNC:2645	8529	ENSG00000186115	PA27121	Methods\n\nThe allele frequency table was made by searching the PubMed® database (1995 to 2016). Allele frequencies reported in and gnomD browser and phase 3 1000 Genomes were also included (https://gnomad.broadinstitute.org/, http://browser.1000genomes.org/index.html) for alleles that contain single unique variant.\n\nCaveats to estimated allele, diplotype and phenotype frequencies:\n\nSampling. Allele frequencies collected by CPIC for the supplemental tables are based on published literature reports which typically study small groups of people based on a geographic location (e.g. Malaysia, Berlin, Cairo). Almost no studies use genetic markers to estimate ancestry. Manuscripts are often focused on a specific phenotype (e.g. disease) or study only individuals taking a particular drug. Such samples would not be considered a random sample of the general population. Another consideration is that sample size is important, and PGx studies are typically not large. The frequencies collected from these studies are then used to estimate general estimates of entire ethnic population allele frequencies. Therefore, frequencies from larger groups of subjects and frequencies averaged from many sample populations probably result in better estimates.\n\nEstimation of *1 frequency. In general, there are no population studies that test for all known variant alleles. Because *1 is not genotyped directly in many studies, all alleles that are negative for a sequence variation are defaulted to a *1 assignment. Because CYP4F2*1 is not genotyped directly, all alleles that are negative for a sequence variation are defaulted to a CYP4F2*1 assignment. Likewise, sequence variations of alleles that are not tested may default to a CYP4F2*1 assignment and hence contribute to the frequencies reported for this allele. Therefore, the inferred frequency for CYP4F2*1 was calculated as an average from studies describing allele frequencies for the most common alleles found in a particular biogeographical group.\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details can be found at https://www.pharmgkb.org/page/biogeographicalGroups. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.	PHENOTYPE	348	CYP4F2 diplotype to phenotype translation is not applicable to the warfarin guideline.	https://cpicpgx.org/gene/cyp4f2/	\N	Legacy Name/Class	f	f
BCHE	chr3	NG_009031	NP_000046	\N	\N	HGNC:983	590	ENSG00000114200	PA25294	\N	PHENOTYPE	114	\N	\N	\N	\N	t	t
TYMS	chr18	\N	NP_001062	\N	\N	HGNC:12441	7298	ENSG00000176890	PA359	\N	PHENOTYPE	115	\N	\N	\N	\N	t	t
ABCG2	chr4	NG_032067.2	NP_001335914.1	NC_000004.12	NM_004827.3	HGNC:74	9429	ENSG00000118777	PA390	Methods\n\nThe allele frequency table was made by searching the Genome Aggregation Database (gnomAD) and 1000 Genomes phase 3 data by rsID. In addition, pubmed were also searched to include frequencies for certain biogeographical groups (eg. Oceanian and American).\n\nCaveats to estimated allele, frequencies:\n\nSampling. Allele frequencies collected by CPIC for the supplemental tables are based on published literature reports which typically study small groups of people based on a geographic location (e.g. Malaysia, Berlin, Cairo). Almost no studies use genetic markers to estimate ancestry. Manuscripts are often focused on a specific phenotype (e.g. disease) or study only individuals taking a particular drug. Such samples would not be considered a random sample of the general population. Another consideration is that sample size is important, and PGx studies are typically not large. The frequencies collected from these studies are then used to estimate general estimates of entire ethnic population allele frequencies. Therefore, frequencies from larger groups of subjects and frequencies averaged from many sample populations probably result in better estimates.\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details, including the definitions of each group, can be found at https://www.pharmgkb.org/page/biogeographicalGroups. We strongly recommend that users use either the publication or the PharmGKB link provided to familiarize themselves with the grouping system before using these allele frequencies. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.	PHENOTYPE	345	\N	https://cpicpgx.org/gene/abcg2/	\N	\N	t	t
ACYP2	\N	\N	\N	\N	\N	HGNC:180	98	ENSG00000170634	PA24500	\N	PHENOTYPE	88	\N	\N	\N	\N	t	t
UMPS	chr3	NG_017037	NP_000364	\N	\N	HGNC:12563	7372	ENSG00000114491	PA363	\N	PHENOTYPE	114	\N	\N	\N	\N	t	t
CFTR	chr7	NG_016465.4	NP_000483.3	NC_000007.14	NM_000069.2	HGNC:1884	1080	ENSG00000001626	PA109	\N	PHENOTYPE	334	\N	https://cpicpgx.org/gene/cftr/	\N	Legacy Name/Class	t	t
CYP2C9	chr10	NG_008385.2	NP_000762.2	NC_000010.11	NM_000069.2	HGNC:2623	1559	ENSG00000138109	PA126	Methods\n\nThe allele frequency table was made by searching the PubMed® database (1995 to July 2019). The following criteria were used for CYP2C9: (CYP2C9 or 2C9 or cytochrome P4502C9) AND (genotype OR allele OR frequency OR minor allele OR variant OR ethnic OR race OR racial OR ethnicity OR population) with filter limits set to retrieve "full-text" and "English" literature. In addition, reports were also identified from citations by others or review articles. Studies were considered for inclusion in the CYP2C9 frequency table if: (1) the ethnicity of the population was clearly indicated, (2) either allele frequencies or genotype frequencies were reported, (3) the method by which the genes were genotyped was indicated, (4) the sample population consisted of at least 50 individuals with a few exceptions (e.g., smaller cohorts that were part of larger studies) and (5) the study represented an original publication (no reviews or meta-analyses). Allele frequencies reported in and gnomD browser and phase 3 1000 Genomes were also included (https://gnomad.broadinstitute.org/, http://browser.1000genomes.org/index.html) for alleles that contain single unique variant.\n\nDiplotype and Phenotype Calculations. Diplotype and phenotype frequencies were estimated using the equation describing Hardy Weinberg equilibrium based on reported allele frequencies.\n\nCaveats to estimated allele, diplotype and phenotype frequencies:\n\nSampling. Allele frequencies collected by CPIC for the supplemental tables are based on published literature reports which typically study small groups of people based on a geographic location (e.g. Malaysia, Berlin, Cairo). Almost no studies use genetic markers to estimate ancestry. Manuscripts are often focused on a specific phenotype (e.g. disease) or study only individuals taking a particular drug. Such samples would not be considered a random sample of the general population. Another consideration is that sample size is important, and PGx studies are typically not large. The frequencies collected from these studies are then used to estimate general estimates of entire ethnic population allele frequencies. Therefore, frequencies from larger groups of subjects and frequencies averaged from many sample populations probably result in better estimates.\n\nEstimation of *1 frequency. In general, there are no population studies that test for all known variant alleles. Because *1 is not genotyped directly in many studies, all alleles that are negative for a sequence variation are defaulted to a *1 assignment. Because CYP2C9*1 is not genotyped directly, all alleles that are negative for a sequence variation are defaulted to a CYP2C9*1 assignment. Likewise, sequence variations of alleles that are not tested may default to a CYP2C9*1 assignment and hence contribute to the frequencies reported for this allele. Therefore, the inferred frequency for CYP2C9*1 was calculated as an average from studies describing allele frequencies for the most common alleles found in a particular biogeographical group.\n\nDiplotype/Phenotype frequency estimates. When calculating diplotype frequencies from these allele frequencies, the margin of error is compounded based on the margin of error on each allele in the diplotype. So, the margin of error will necessarily increase for diplotype frequency estimates compared to allele frequency estimates. For allele frequencies with already large margins of error due to small and non-random sampling, the diplotype margin of error could potentially be quite large. On the other hand, for well-studied alleles, the margin of error is likely low.\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details can be found at https://www.pharmgkb.org/page/biogeographicalGroups. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.	ACTIVITY_SCORE	449	CYP2C9 diplotype to phenotype translation is not applicable to the warfarin guideline.	https://cpicpgx.org/gene/cyp2c9/	Methods:\nThe PubMed and PharmGKB databases were searched for the following keywords: (CYP2C9 OR cytochrome p450 2c9)AND [genomic identifiers (e.g. dbSNP rs number, star alleles, additional common names)] AND English [Language]. Study inclusion criteria included publications that incorporated analyses for the association between CYP2C9 genotype and drug pharmacokinetic parameters, clinical outcomes, or allele function.	Legacy Name/Class	t	t
UGT1A1	chr2	NG_002601.2	NP_000454.1	NC_000002.12	NM_000540.2	HGNC:12530	54658	ENSG00000241635	PA420	Methods\n\nThe allele frequency table was made by searching the PubMed® database (1995 to 2015). Allele frequencies reported in phase 3 1000 Genomes were also included (http://browser.1000genomes.org/index.html).\n\nCaveats to estimated allele, diplotype and phenotype frequencies:\n\nSampling. Allele frequencies collected by CPIC for the supplemental tables are based on published literature reports which typically study small groups of people based on a geographic location (e.g. Malaysia, Berlin, Cairo). Almost no studies use genetic markers to estimate ancestry. Manuscripts are often focused on a specific phenotype (e.g. disease) or study only individuals taking a particular drug. Such samples would not be considered a random sample of the general population. Another consideration is that sample size is important, and PGx studies are typically not large. The frequencies collected from these studies are then used to estimate general estimates of entire ethnic population allele frequencies. Therefore, frequencies from larger groups of subjects and frequencies averaged from many sample populations probably result in better estimates.\n\nEstimation of *1 frequency. In general, there are no population studies that test for all known variant alleles. Because *1 is not genotyped directly in many studies, all alleles that are negative for a sequence variation are defaulted to a *1 assignment. Because UGT1A1*1 is not genotyped directly, all alleles that are negative for a sequence variation are defaulted to a UGT1A1*1 assignment. Likewise, sequence variations of alleles that are not tested may default to a UGT1A1*1 assignment and hence contribute to the frequencies reported for this allele. Therefore, the inferred frequency for UGT1A1*1 was calculated as an average from studies describing allele frequencies for the most common alleles found in a particular biogeographical group.\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details can be found at https://www.pharmgkb.org/page/biogeographicalGroups. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.	PHENOTYPE	438	\N	https://cpicpgx.org/gene/ugt1a1/	\N	Nucleotide changes from the UGT nomenclature page: https://www.pharmacogenomics.pha.ulaval.ca/wp-content/uploads/2015/04/UGT1A1-allele-nomenclature.html	f	f
VDR	chr12	NG_008731	NP_000367	\N	\N	HGNC:12679	7421	ENSG00000111424	PA37301	\N	PHENOTYPE	114	\N	\N	\N	\N	t	t
COMT	chr22	NG_011526	NP_000745	\N	\N	HGNC:2228	1312	ENSG00000093010	PA117	\N	PHENOTYPE	108	\N	https://cpicpgx.org/gene/comt/	\N	\N	t	t
CYP2C8	chr10	NG_007972	NP_000761	\N	\N	HGNC:2622	1558	ENSG00000138115	PA125	\N	PHENOTYPE	114	\N	\N	\N	\N	t	t
CYP3A4	chr7	NG_000004	NP_059488	\N	\N	HGNC:2637	1576	ENSG00000160868	PA130	\N	PHENOTYPE	114	\N	\N	\N	\N	t	t
CYP2D6	chr22	NG_008376.4	NP_000097.3	NC_000022.11	NM_000069.2	HGNC:2625	1565	ENSG00000100197	PA128	Methods:\n\nThe CYP2D6 allele frequency tables (CYP2D6 frequency table; link to PharmGKB) are updates of those previously published in CPIC guidelines (PMID: 25974703, 24458010). Updates to the CYP2D6 allele frequency tables were made by searching the PubMed® database (1995 to 2018). The following criteria were used for CYP2D6: (CYP2D6 or 2D6 or cytochrome P4502D6) AND (genotype OR allele OR frequency OR minor allele OR variant OR ethnic OR race OR racial OR ethnicity) with filter limits set to retrieve "full-text" and "English" literature. In addition, reports were also identified from citations by others or review articles. Studies were considered for inclusion in the CYP2D6 frequency table if: (1) the ethnicity of the population was clearly indicated, (2) either allele frequencies or genotype frequencies were reported, (3) the method by which the genes were genotyped was indicated, (4) the sample population consisted of at least 50 individuals with a few exceptions (e.g., smaller cohorts that were part of larger studies) and (5) the study represented an original publication (no reviews or meta-analyses).\nDiplotype and phenotype frequencies were estimated using the equation describing Hardy Weinberg equilibrium based on reported allele frequencies. Because the frequencies for each allele are averages from all studies for that population, allele frequencies may not add up to100%. To account for this in diplotype and phenotype frequencies calculations, *1 frequency was calculated as 1 - sum (non *1 allele frequency).\n\n\nCaveats to estimated allele, diplotype and phenotype frequencies:\n\nSampling. Allele frequencies collected by CPIC for the supplemental tables are based on published literature reports which typically study small groups of people based on a geographic location (e.g. Malaysia, Berlin, Cairo). Almost no studies use genetic markers to estimate ancestry. Manuscripts are often focused on a specific phenotype (e.g. disease) or study only individuals taking a particular drug. Such samples would not be considered a random sample of the general population. Another consideration is that sample size is important, and PGx studies are typically not large. The frequencies collected from these studies are then used to estimate general estimates of entire ethnic population allele frequencies. Therefore, frequencies from larger groups of subjects and frequencies averaged from many sample populations probably result in better estimates.\n\nEstimation of *1 frequency. In general, there are no population studies that test for all known variant alleles. Because CYP2D6*1 is not genotyped directly, all alleles that are negative for a sequence variation are defaulted to a CYP2D6*1 assignment. Likewise, sequence variations of alleles that are not tested may default to a CYP2D6*1 assignment and hence contribute to the frequencies reported for this allele. Therefore, the inferred frequency for CYP2D6*1 was calculated as an average from studies describing allele frequencies for the most common alleles found in a particular ethnic group.\n\nDiplotype/Phenotype frequency estimates. When calculating diplotype frequencies from these allele frequencies, the margin of error is compounded based on the margin of error on each allele in the diplotype. So, the margin of error will necessarily increase for diplotype frequency estimates compared to allele frequency estimates. For allele frequencies with already large margins of error due to small and non-random sampling, the diplotype margin of error could potentially be quite large. On the other hand, for well-studied alleles, the margin of error is likely low.\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details, including the definitions of each group, can be found at https://www.pharmgkb.org/page/biogeographicalGroups. We strongly recommend that users use either the publication or the PharmGKB link provided to familiarize themselves with the grouping system before using these allele frequencies. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.\n\nOverestimation of allele frequencies. CYP2D6*2 is a 'default' assignment and, unless tested and discriminated for CYP2D6*8, *11, *17, *35,*41 and other variants, will default to a CYP2D6*2 assignment. The frequencies shown here may therefore be over-estimated. CYP2D6*10 is a 'default' assignment and, unless tested and discriminated for, CYP2D6*14 and *36 and other variants, will default to a CYP2D6*10 assignment. The frequencies shown here may therefore be over-estimated. CYP2D6*17 is a 'default' assignment and, unless tested and discriminated for, CYP2D6*40 and *58 will default to a CYP2D6*17 assignment. The frequencies shown here may therefore be over-estimated. CYP2D6*41 has not consistently been determined by its defining SNP (2988G>A) across studies; some platforms still use the -1584C>G SNP to discriminate between CYP2D6*2 and *41. This may lead to an overestimation of the CYP2D6*41 frequency, especially in those of African ancestry.\n\nCNV alleles. Many studies do not specify the exact copy number of duplicated alleles found in their study population and instead report the total frequency of observed CNVs as "xN". Where possible, these frequencies have been included in the CNV column for that allele (e.g. *1xN frequencies are included in the *1x2 column, *4xN frequencies are included in the *4x2 column). Users should be aware that this will lead to an overestimation of the frequency of that exact copy number in the population.	ACTIVITY_SCORE	444	\N	https://cpicpgx.org/gene/cyp2d6/	\N	Legacy Name/Class	t	t
HLA-B	chr6	NG_002397	NP_005505	\N	\N	HGNC:4932	3106	ENSG00000234745	PA35056	Methods\n\nThe allele frequency table was made by searching the PubMed® database (1995 to September 2019). The following criteria were used for HLA-B: (HLA-B) AND (allele OR frequency). In addition, reports were also identified from citations by others or review articles. Studies were considered for inclusion in the HLA-B frequency table if: (1) the ethnicity of the population was clearly indicated, (2) either allele frequencies or genotype frequencies were reported, (3) the method by which the genes were genotyped was indicated, (4) the sample population consisted of at least 50 individuals with a few exceptions (e.g., smaller cohorts that were part of larger studies) and (5) the study represented an original publication (no reviews or meta-analyses). Allele frequencies reported in phase 3 1000 Genomes (http://browser.1000genomes.org/index.html) and from allelefrequencies.net (https://www.allelefrequencies.net) were also included .\nCaveats to estimated allele, diplotype and phenotype frequencies:\n\nSampling. Allele frequencies collected by CPIC for the supplemental tables are based on published literature reports which typically study small groups of people based on a geographic location (e.g. Malaysia, Berlin, Cairo). Almost no studies use genetic markers to estimate ancestry. Manuscripts are often focused on a specific phenotype (e.g. disease) or study only individuals taking a particular drug. Such samples would not be considered a random sample of the general population. Another consideration is that sample size is important, and PGx studies are typically not large. The frequencies collected from these studies are then used to estimate general estimates of entire ethnic population allele frequencies. Therefore, frequencies from larger groups of subjects and frequencies averaged from many sample populations probably result in better estimates.\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details, including the definitions of each group, can be found at https://www.pharmgkb.org/page/biogeographicalGroups. We strongly recommend that users use either the publication or the PharmGKB link provided to familiarize themselves with the grouping system before using these allele frequencies. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.	ALLELE_STATUS	224	\N	https://cpicpgx.org/gene/hla/	\N	\N	f	f
EPHX1	chr1	NG_009776	NP_000111	\N	\N	HGNC:3401	2052	ENSG00000143819	PA27829	\N	PHENOTYPE	114	\N	\N	\N	\N	t	t
GGCX	chr2	NG_011811	NP_000812	\N	\N	HGNC:4247	2677	ENSG00000115486	PA28660	\N	PHENOTYPE	114	\N	\N	\N	\N	t	t
GP1BA	chr17	NG_008767	NP_000164	\N	\N	HGNC:4439	2811	ENSG00000185245	PA178	\N	PHENOTYPE	114	\N	\N	\N	\N	t	t
GSTP1	chr11	NG_012075	NP_000843	\N	\N	HGNC:4638	2950	ENSG00000084207	PA29028	\N	PHENOTYPE	114	\N	\N	\N	\N	t	t
HTR2A	chr13	NG_013011	NP_000612	\N	\N	HGNC:5293	3356	ENSG00000102468	PA193	\N	PHENOTYPE	114	\N	\N	\N	\N	t	t
MTHFR	chr1	NG_013351	NP_005948	\N	\N	HGNC:7436	4524	ENSG00000177000	PA245	\N	PHENOTYPE	114	\N	\N	\N	\N	t	t
NQO1	chr16	NG_011504	NP_000894	\N	\N	HGNC:2874	1728	ENSG00000181019	PA31744	\N	PHENOTYPE	114	\N	\N	\N	\N	t	t
PROC	chr2	NG_016323	NP_000303	\N	\N	HGNC:9451	5624	ENSG00000115718	PA33799	\N	PHENOTYPE	114	\N	\N	\N	\N	t	t
PROS1	chr3	NG_009813	NP_000304	\N	\N	HGNC:9456	5627	ENSG00000184500	PA33809	\N	PHENOTYPE	114	\N	\N	\N	\N	t	t
SCN1A	chr2	NG_011906	NP_008851	\N	\N	HGNC:10585	6323	ENSG00000144285	PA301	\N	PHENOTYPE	114	\N	\N	\N	\N	t	t
SLC6A4	chr17	NG_011747	NP_001036	\N	\N	HGNC:11050	6532	ENSG00000108576	PA312	\N	PHENOTYPE	114	\N	\N	\N	\N	t	t
CYP3A5	chr7	NG_007938.2	NP_000768.1	NC_000007.14	NM_000069.2	HGNC:2638	1577	ENSG00000106258	PA131	Methods\n\nThe allele frequency table was made by searching the PubMed® database (1995 to 2014).\n\nDiplotype and Phenotype Calculations. Diplotype and phenotype frequencies were estimated using the equation describing Hardy Weinberg equilibrium based on reported allele frequencies.\n\nCaveats to estimated allele frequencies:\n\nSampling. Allele frequencies collected by CPIC for the supplemental tables are based on published literature reports which typically study small groups of people based on a geographic location (e.g. Malaysia, Berlin, Cairo). Almost no studies use genetic markers to estimate ancestry. Manuscripts are often focused on a specific phenotype (e.g. disease) or study only individuals taking a particular drug. Such samples would not be considered a random sample of the general population. Another consideration is that sample size is important, and PGx studies are typically not large. The frequencies collected from these studies are then used to estimate general estimates of entire ethnic population allele frequencies. Therefore, frequencies from larger groups of subjects and frequencies averaged from many sample populations probably result in better estimates.\n\nEstimation of *1 frequency. In general, there are no population studies that test for all known variant alleles. Because *1 is not genotyped directly in many studies, all alleles that are negative for a sequence variation are defaulted to a *1 assignment. Because CYP3A5*1 is not genotyped directly, all alleles that are negative for a sequence variation are defaulted to a CYP3A5*1 assignment. Likewise, sequence variations of alleles that are not tested may default to a CYP3A5*1 assignment and hence contribute to the frequencies reported for this allele. Therefore, the inferred frequency for CYP3A5*1 was calculated as an average from studies describing allele frequencies for the most common alleles found in a particular biogeographical group.\n\nDiplotype/Phenotype frequency estimates. Diplotype and phenotype frequencies were estimated using the equation describing Hardy Weinberg equilibrium based on reported allele frequencies. When calculating diplotype frequencies from these allele frequencies, the margin of error is compounded based on the margin of error on each allele in the diplotype. So, the margin of error will necessarily increase for diplotype frequency estimates compared to allele frequency estimates. For allele frequencies with already large margins of error due to small and non-random sampling, the diplotype margin of error could potentially be quite large. On the other hand, for well-studied alleles, the margin of error is likely low.\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details, including the definitions of each group, can be found at https://www.pharmgkb.org/page/biogeographicalGroups. We strongly recommend that users use either the publication or the PharmGKB link provided to familiarize themselves with the grouping system before using these allele frequencies. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.\n	PHENOTYPE	443	\N	https://cpicpgx.org/gene/cyp3a5/	\N	Legacy Name/Class	t	t
SLCO1B1	chr12	NG_011745.1	NP_006437.3	NC_000012.12	NM_000540.2	HGNC:10959	10599	ENSG00000134538	PA134865839	Methods\n\nThe allele frequency table was made by searching the PubMed® database (1995 to 2021).\n\nCaveats to estimated allele frequencies:\n\nSampling. Allele frequencies collected by CPIC for the supplemental tables are based on published literature reports which typically study small groups of people based on a geographic location (e.g. Malaysia, Berlin, Cairo). Almost no studies use genetic markers to estimate ancestry. Manuscripts are often focused on a specific phenotype (e.g. disease) or study only individuals taking a particular drug. Such samples would not be considered a random sample of the general population. Another consideration is that sample size is important, and PGx studies are typically not large. The frequencies collected from these studies are then used to estimate general estimates of entire ethnic population allele frequencies. Therefore, frequencies from larger groups of subjects and frequencies averaged from many sample populations probably result in better estimates.\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details can be found at https://www.pharmgkb.org/page/biogeographicalGroups. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.	PHENOTYPE	436	\N	https://cpicpgx.org/gene/slco1b1/	\N	Common name	t	t
CYP2C19	chr10	NG_008384.3	NP_000760.1	NC_000010.11	NM_000069.2	HGNC:2621	1557	ENSG00000165841	PA124	Methods:\nThe CYP2C19 frequency table includes updates of those previously published in CPIC guidelines. Updates to the CYP2C19 frequency tables were made by searching the PubMed® database (1995 to 2015). The following criteria were used for CYP2C19: (CYP2C19 or 2C19 or cytochrome P4502C19) AND (genotype OR allele OR frequency OR minor allele OR variant OR ethnic OR race OR racial OR ethnicity) with filter limits set to retrieve "full-text" and "English" literature. In addition, reports were also identified from citations by others or review articles. Studies were considered for inclusion in the CYP2C19 frequency table if: (1) the ethnicity of the population was clearly indicated, (2) either allele frequencies or genotype frequencies were reported, (3) the method by which the genes were genotyped was indicated, (4) the sample population consisted of at least 50 individuals with a few exceptions (e.g., smaller cohorts that were part of larger studies) and (5) the study represented an original publication (no reviews or meta-analyses). Diplotype and phenotype frequencies were estimated using the equation describing Hardy Weinberg equilibrium based on reported allele frequencies.\n\nDiplotype and Phenotype Calculations. Diplotype and phenotype frequencies were estimated using the equation describing Hardy Weinberg equilibrium based on reported allele frequencies.\n\nCaveats to estimated allele, diplotype and phenotype frequencies:\n\nSampling. Allele frequencies collected by CPIC for the supplemental tables are based on published literature reports which typically study small groups of people based on a geographic location (e.g. Malaysia, Berlin, Cairo). Almost no studies use genetic markers to estimate ancestry. Manuscripts are often focused on a specific phenotype (e.g. disease) or study only individuals taking a particular drug. Such samples would not be considered a random sample of the general population. Another consideration is that sample size is important, and PGx studies are typically not large. The frequencies collected from these studies are then used to estimate general estimates of entire ethnic population allele frequencies. Therefore, frequencies from larger groups of subjects and frequencies averaged from many sample populations probably result in better estimates.\n\nEstimation of *1 frequency. In general, there are no population studies that test for all known variant alleles. Because *1 is not genotyped directly in many studies, all alleles that are negative for a sequence variation are defaulted to a *1 assignment. The inferred frequency for *1 is estimated as: 100 - (sum of averaged variant allele frequencies). For genes where many alleles are not tested for in any population, and frequency of 'common' alleles is not well documented in many understudied populations (Oceanian, Central/South Asian, Latino), the *1 frequency will deviate even more from true values.\n\nDiplotype/Phenotype frequency estimates. Diplotype and phenotype frequencies were estimated using the equation describing Hardy Weinberg equilibrium based on reported allele frequencies. When calculating diplotype frequencies from these allele frequencies, the margin of error is compounded based on the margin of error on each allele in the diplotype. So, the margin of error will necessarily increase for diplotype frequency estimates compared to allele frequency estimates. For allele frequencies with already large margins of error due to small and non-random sampling, the diplotype margin of error could potentially be quite large. On the other hand, for well-studied alleles, the margin of error is likely low.\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details, including the definitions of each group, can be found at https://www.pharmgkb.org/page/biogeographicalGroups. We strongly recommend that users use either the publication or the PharmGKB link provided to familiarize themselves with the grouping system before using these allele frequencies. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.	PHENOTYPE	447	\N	https://cpicpgx.org/gene/cyp2c19/	\N	Legacy Name/Class	t	t
IFNL3	chr19	NG_042193.1	NP_000101.2	NC_000019.10	NM_001042351.2	HGNC:18365	282617	ENSG00000197110	PA134952671	\N	ALLELE_STATUS	234	\N	https://cpicpgx.org/gene/ifnl/	\N	Common Name	t	t
G6PD	chrX	NG_009015.2	NP_000101.2	NC_000023.11	NM_001042351.2	HGNC:4057	2539	ENSG00000160211	PA28469	Methods\n\nThe allele frequency table was made by searching the gnomAD database.\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details can be found at https://www.pharmgkb.org/page/biogeographicalGroups. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n	PHENOTYPE	392	\N	https://cpicpgx.org/gene/g6pd/	\N	Legacy Name/Class	f	f
TPMT	chr6	NG_012137.3	NP_000358.1	NC_000006.12	NM_000540.2	HGNC:12014	7172	ENSG00000137364	PA356	The allele frequency table was made by searching the PubMed® database (no start date to 1/2018). Allele frequencies reported in the gnomAD browser (http://gnomad.broadinstitute.org/ - exomes and genomes) and ensembl (grch37.ensembl.org - exomes or genomes) were also included. URLs are included in the "PMID" column.\n\nDiplotype and Phenotype Calculations. Diplotype and phenotype frequencies were estimated using the equation describing Hardy Weinberg equilibrium based on reported allele frequencies.\n\nCaveats to estimated allele, diplotype and phenotype frequencies:\n\nSampling. Allele frequencies collected by CPIC for the supplemental tables are based on published literature reports which typically study small groups of people based on a geographic location (e.g. Malaysia, Berlin, Cairo). Almost no studies use genetic markers to estimate ancestry. Manuscripts are often focused on a specific phenotype (e.g. disease) or study only individuals taking a particular drug. Such samples would not be considered a random sample of the general population. Another consideration is that sample size is important, and PGx studies are typically not large. The frequencies collected from these studies are then used to estimate general estimates of entire ethnic population allele frequencies. Therefore, frequencies from larger groups of subjects and frequencies averaged from many sample populations probably result in better estimates.\n\nEstimation of *1 frequency. In general, there are no population studies that test for all known variant alleles. Because *1 is not genotyped directly in many studies, all alleles that are negative for a sequence variation are defaulted to a *1 assignment. The inferred frequency for *1 is estimated as: 100 - (sum of averaged variant allele frequencies). For genes where many alleles are not tested for in any population, and frequency of 'common' alleles is not well documented in many understudied populations (Oceania, South Asian, Latino), the *1 frequency will deviate even more from true values.\n\nDiplotype/Phenotype frequency estimates. Diplotype and phenotype frequencies were estimated using the equation describing Hardy Weinberg equilibrium based on reported allele frequencies. When calculating diplotype frequencies from these allele frequencies, the margin of error is compounded based on the margin of error on each allele in the diplotype. So, the margin of error will necessarily increase for diplotype frequency estimates compared to allele frequency estimates. For allele frequencies with already large margins of error due to small and non-random sampling, the diplotype margin of error could potentially be quite large. On the other hand, for well-studied alleles, the margin of error is likely low.\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details can be found at https://www.pharmgkb.org/page/biogeographicalGroups. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.	PHENOTYPE	436	\N	https://cpicpgx.org/gene/tpmt/	\N	Nucleotide change on cDNA from https://liu.se/en/research/tpmt-nomenclature-committee	t	t
CYP2B6	chr19	NG_007929.1	NP_000758.1	NC_000019.10	NM_000069.2	HGNC:2615	1555	ENSG00000197408	PA123	Methods\n\nThe allele frequency table was made by searching the PubMed® database (no start date to May 2018). Studies were considered for inclusion in the CYP2B6 Frequency Table if (1) the ethnicity of the population was clearly indicated; (2) either allele frequencies or genotype frequencies were reported; and (3) the method by which genes were genotyped was indicated. Allele frequencies reported in the gnomAD browser (http://gnomad.broadinstitute.org/ - exomes and genomes) and 1000 Genomes Project phase 3 data on Ensemble browser (https://uswest.ensembl.org/index.html) were also included.\n\nDiplotype and Phenotype Calculations. Diplotype and phenotype frequencies were estimated using the equation describing Hardy Weinberg equilibrium based on reported allele frequencies.\n\nCaveats to estimated allele, diplotype and phenotype frequencies:\n\nSampling. Allele frequencies collected by CPIC for the supplemental tables are based on published literature reports which typically study small groups of people based on a geographic location (e.g. Malaysia, Berlin, Cairo). Almost no studies use genetic markers to estimate ancestry. Manuscripts are often focused on a specific phenotype (e.g. disease) or study only individuals taking a particular drug. Such samples would not be considered a random sample of the general population. Another consideration is that sample size is important, and PGx studies are typically not large. Studies were included in the frequency calculation regardless of number. The frequencies collected from these studies are then used to estimate general estimates of entire ethnic population allele frequencies. Therefore, frequencies from larger groups of subjects and frequencies averaged from many sample populations probably result in better estimates.\n\nEstimation of *1 frequency. In general, there are no population studies that test for all known variant alleles. Because *1 is not genotyped directly in many studies, all alleles that are negative for a sequence variation are defaulted to a *1 assignment. The inferred frequency for *1 is estimated as: 1 - (sum of averaged variant allele frequencies). For genes where many alleles are not tested for in any population, and frequency of 'common' alleles is not well documented in many understudied populations (Oceania, Middle eastern, South Asian, Latino), the *1 frequency will deviate even more from true values.\n\nDiplotype/Phenotype frequency estimates. Diplotype and phenotype frequencies were estimated using the equation describing Hardy Weinberg equilibrium based on reported allele frequencies. When calculating diplotype frequencies from these allele frequencies, the margin of error is compounded based on the margin of error on each allele in the diplotype. So, the margin of error will necessarily increase for diplotype frequency estimates compared to allele frequency estimates. For allele frequencies with already large margins of error due to small and non-random sampling, the diplotype margin of error could potentially be quite large. On the other hand, for well-studied alleles, the margin of error is likely low.\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details, including the definitions of each group, can be found at https://www.pharmgkb.org/page/biogeographicalGroups. We strongly recommend that users use either the publication or the PharmGKB link provided to familiarize themselves with the grouping system before using these allele frequencies. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.	PHENOTYPE	448	\N	https://cpicpgx.org/gene/cyp2b6/	\N	Legacy Name/Class	t	t
VKORC1	chr16	NG_011564.1	NP_076869.1	NC_000016.10	NM_000540.2	HGNC:23663	79001	ENSG00000167397	PA133787052	Methods\n\nThe allele frequency table was made by searching the PubMed® database (1995 to 2016). Allele frequencies reported in phase 3 1000 Genomes were also included (http://browser.1000genomes.org/index.html).\n\nCaveats to estimated allele, diplotype and phenotype frequencies:\n\nSampling. Allele frequencies collected by CPIC for the supplemental tables are based on published literature reports which typically study small groups of people based on a geographic location (e.g. Malaysia, Berlin, Cairo). Almost no studies use genetic markers to estimate ancestry. Manuscripts are often focused on a specific phenotype (e.g. disease) or study only individuals taking a particular drug. Such samples would not be considered a random sample of the general population. Another consideration is that sample size is important, and PGx studies are typically not large. The frequencies collected from these studies are then used to estimate general estimates of entire ethnic population allele frequencies. Therefore, frequencies from larger groups of subjects and frequencies averaged from many sample populations probably result in better estimates.\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details can be found at https://www.pharmgkb.org/page/biogeographicalGroups. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.	PHENOTYPE	343	VKORC1 diplotype to phenotype translation is not applicable to the warfarin guideline.	https://cpicpgx.org/gene/vkorc1/	\N	Common Name	f	f
CACNA1S	chr1	NG_009816.1	NP_000060.2	NC_000001.11	NM_000069.2	HGNC:1397	779	ENSG00000081248	PA85	Methods\n\nThe allele frequency table was made by searching the Genome Aggregation Database (gnomAD) by each rsID\n\nCaveats to estimated allele, frequencies:\n\nSampling. Allele frequencies collected by CPIC for the supplemental tables are based on published literature reports which typically study small groups of people based on a geographic location (e.g. Malaysia, Berlin, Cairo). Almost no studies use genetic markers to estimate ancestry. Manuscripts are often focused on a specific phenotype (e.g. disease) or study only individuals taking a particular drug. Such samples would not be considered a random sample of the general population. Another consideration is that sample size is important, and PGx studies are typically not large. The frequencies collected from these studies are then used to estimate general estimates of entire ethnic population allele frequencies. Therefore, frequencies from larger groups of subjects and frequencies averaged from many sample populations probably result in better estimates.\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details, including the definitions of each group, can be found at https://www.pharmgkb.org/page/biogeographicalGroups. We strongly recommend that users use either the publication or the PharmGKB link provided to familiarize themselves with the grouping system before using these allele frequencies. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.	PHENOTYPE	449	\N	https://cpicpgx.org/gene/cacna1s/	\N	\N	f	f
\.


--
-- Data for Name: gene_result; Type: TABLE DATA; Schema: cpic; Owner: -
--

COPY cpic.gene_result (id, genesymbol, result, activityscore, ehrpriority, consultationtext, version, frequency) FROM stdin;
7983656	CFTR	ivacaftor non-responsive in CF patients	n/a	\N	\N	1	\N
8087846	TPMT	Intermediate Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a normal function allele and one copy of a no function allele OR two copies of a decreased function allele. Based on the genotype result this patient is predicted to be a TPMT intermediate metabolizer. This patient may be at risk for an adverse reactions to medications that are metabolized by TPMT (eg. thiopurines). To avoid an untoward drug response, dose adjustments or alternative therapeutic agents may be necessary for medications metabolized by TPMT. However, thiopurines can be affected by a patient's TPMT and NUDT15 phenotype. Please consult a clinical pharmacist for more information about how TPMT and NUDT15 metabolic status influences drug selection and dosing.	3	{"Latino": 0.10138224, "European": 0.087302946, "East Asian": 0.039815668, "Near Eastern": 0.06641302, "Central/South Asian": 0.036385097, "Sub-Saharan African": 0.10365061, "African American/Afro-Caribbean": 0.069424435}
8087886	TPMT	Poor Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has two copies of a no function allele. Based on the genotype result this patient is predicted to be a TPMT poor metabolizer. This patient may be at a high risk for an adverse reactions to medications that are metabolized by TPMT (eg. thiopurines). To avoid an untoward drug response, dose adjustments or or alternative therapy may be necessary for medications metabolized by TPMT. However, thiopurines can be affected by a patient's TPMT and NUDT15 phenotype. Please consult a clinical pharmacist for more information about how TPMT and NUDT16 metabolic status influences drug selection and dosing.	3	{"Latino": 0.0028794738, "European": 0.0020956735, "East Asian": 0.00041297937, "Near Eastern": 0.0011826118, "Central/South Asian": 0.0003435882, "Sub-Saharan African": 0.002971174, "African American/Afro-Caribbean": 0.0013917874}
8088675	TPMT	Indeterminate	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a normal function allele and one copy of an uncertain or unknown function allele OR one copy of a decreased function allele and one copy of an uncertain or unknown function allele OR two copies of an uncertain or unknown function allele. The expected phenotype for this patient cannot be determined currently based on the TPMT diplotype result. Consider evaluating TPMT erythrocyte activity to assess TPMT phenotype. Erythrocyte TPMT activity test results can be falsely low at diagnosis of leukemia and is unreliable in the case of recent red blood cell transfusions. If thiopurines are required and TPMT status is unknown, monitor closely for toxicity. Please consult a clinical pharmacist for more specific information about how TPMT function influences drug dosing.	3	{"Latino": 0.0032013063, "European": 0.0013079308, "East Asian": 0.000104039, "Near Eastern": 0.0, "Central/South Asian": 0.0, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": 0.06207684}
7988646	CYP2D6	Ultrarapid Metabolizer	2.75	Abnormal/Priority/High Risk	This result signifies that this patient has [X copies of a normal function allele (*_xN)] [X copies of a decreased function allele (*_)] [X copies of a no function allele (*_)]. Based on the genotype result this patient is predicted to be an ultrarapid metabolizer of CYP2D6 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2D6. To avoid an untoward drug response, dose adjustments may be necessary for medications metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.0, "American": 0.0, "European": 0.0, "Oceanian": 0.0, "East Asian": 0.0, "Near Eastern": 0.0, "Central/South Asian": 0.0, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": 0.0}
7988832	CYP2D6	Normal Metabolizer	2.25	Normal/Routine/ Low Risk	This result signifies that this patient has two copies of a normal function allele (*_x2) and one copy of decreased function allele with an activity value of 0.25 (*_). Based on the genotype result this patient is predicted to be a normal metabolizer of CYP2D6 substrates. There is no reason to selectively adjust the dose of most medications that are metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.005172111, "American": 0.0031386076, "European": 0.004804125, "Oceanian": 0.021296859, "East Asian": 0.0072455397, "Near Eastern": 0.029094387, "Central/South Asian": 0.005050826, "Sub-Saharan African": 0.0048336256, "African American/Afro-Caribbean": 0.004428509}
7988900	CYP2D6	Normal Metabolizer	2.0	Normal/Routine/ Low Risk	This result signifies that this patient has [X copies of a normal function allele (*_xN)] [X copies of a decreased function allele (*_)] [X copies of a no function allele (*_)]. Based on the genotype result this patient is predicted to be a normal metabolizer of CYP2D6 substrates. There is no reason to selectively adjust the dose of most medications that are metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.42007107, "American": 0.57988566, "European": 0.32166475, "Oceanian": 0.48931405, "East Asian": 0.1527359, "Near Eastern": 0.2670007, "Central/South Asian": 0.34187043, "Sub-Saharan African": 0.15406683, "African American/Afro-Caribbean": 0.22171879}
7989190	CYP2D6	Normal Metabolizer	1.5	Normal/Routine/ Low Risk	This result signifies that this patient has [1 copy of a normal function allele (*_)] [X copies of a decreased function allele (*_)] [X copies of a no function allele (*_)]. Based on the genotype result this patient is predicted to be a normal metabolizer of CYP2D6 substrates. There is no reason to selectively adjust the dose of most medications that are metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.051568672, "American": 0.012521543, "European": 0.010339902, "Oceanian": 0.00143701, "East Asian": 0.017062929, "Near Eastern": 0.045171212, "Central/South Asian": 0.0029989334, "Sub-Saharan African": 0.23161727, "African American/Afro-Caribbean": 0.23827769}
7983852	CYP2B6	Poor Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has two copies of a no function allele OR two copies of a decreased function allele OR one copy of a no function allele and one copy of a decreased function allele. Based on the genotype result this patient is predicted to be a poor metabolizer of CYP2B6 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2B6. To avoid an untoward drug response, dose adjustments or or alternative therapy may be necessary for medications metabolized by CYP2B6. Please consult a clinical pharmacist for more information about how CYP2B6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.09452413, "European": 0.07428478, "Oceanian": 0.4096, "East Asian": 0.0436291, "Near Eastern": 0.127449, "Central/South Asian": 0.059536003, "Sub-Saharan African": 0.23673655, "African American/Afro-Caribbean": 0.15714757}
7984109	CYP2B6	Indeterminate	n/a	none	This result signifies that the patient has an allele combination with uncertain and/or unknown function alleles. The expected phenotype for this patient cannot be determined currently based on the CYP2B6 diplotype result. Please consult a clinical pharmacist for more specific information about how CYP2B6 function influences drug dosing.	3	{"Latino": 0.013596146, "European": 0.06145065, "Oceanian": 0.0, "East Asian": 0.020025712, "Near Eastern": 0.0, "Central/South Asian": 0.014973663, "Sub-Saharan African": 0.25210795, "African American/Afro-Caribbean": 0.031204166}
7983670	CYP2B6	Normal Metabolizer	n/a	Normal/Routine/Low Risk	This result signifies that the patient has two copies of normal function alleles. Based on the genotype result this patient is predicted to be an normal metabolizer of CYP2B6 substrates. There is no reason to selectively adjust the dose of most medications that are metabolized by CYP2B6. Please consult a clinical pharmacist for more information about how CYP2B6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.33582056, "European": 0.42950228, "Oceanian": 0.12960002, "East Asian": 0.48562673, "Near Eastern": 0.29052103, "Central/South Asian": 0.42183065, "Sub-Saharan African": 0.14307445, "African American/Afro-Caribbean": 0.333572}
7983662	CYP2B6	Rapid Metabolizer	n/a	Normal/Routine/Low Risk	This result signifies that the patient has one copy of a normal function allele and one copy of an increased function allele. Based on the genotype result this patient is predicted to be a rapid metabolizer of CYP2B6 substrates. There is no reason to selectively adjust the dose of most medications that are metabolized by CYP2B6. Please consult a clinical pharmacist for more information about how CYP2B6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.1231214, "European": 0.05357082, "Oceanian": 0.0, "East Asian": 0.11734093, "Near Eastern": 0.112112, "Central/South Asian": 0.12859802, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": 0.011896482}
8088791	UGT1A1	Indeterminate	n/a	none	This result signifies that the patient has an allele combination with uncertain and/or unknown function alleles. The expected phenotype for this patient cannot be determined currently based on the UGT1A1 diplotype result. UGT1A1*80 is in very high linkage disequilibrium with *28 and *37. In the rare event that *80 is detected but *28 and *37 are not, there are not enough clinical data to predict metabolizer status with certainty. However, if only *80 is interrogated and the patient is heterozygous or homozygous for *80, an intermediate or poor metabolizer phenotype may be inferred, respectively. Please consult a clinical pharmacist for more specific information about how UGT1A1 function influences drug dosing.	2	\N
8088753	UGT1A1	Intermediate Metabolizer	n/a	Normal/Routine/Low Risk	This result signifies that the patient has one copy of a normal function allele (*1) OR one copy of an increased function allele (*36), AND and one copy of a decreased function allele (*_). Based on the genotype result this patient is predicted to be an intermediate metabolizer of UGT1A1 substrates. There is no reason to selectively adjust the dose of most medications that inhibit or are inactivated by UGT1A1. Please consult a clinical pharmacist for more information about how UGT1A1 metabolic status influences drug selection and dosing.	2	\N
8088746	UGT1A1	Normal Metabolizer	n/a	Normal/Routine/Low Risk	This result signifies that the patient has two copies of a normal function allele (*1) OR one copy of a normal function allele (*1) and one copy of an increased function allele (*36) OR two copies of an increased function allele (*36). Based on the genotype result this patient is predicted to be an normal metabolizer of UGT1A1 substrates. There is no reason to selectively adjust the dose of most medications that inhibit or are inactivated by UGT1A1. Please consult a clinical pharmacist for more information about how UGT1A1 metabolic status influences drug selection and dosing.	2	\N
8088768	UGT1A1	Poor Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has two copies of decreased function alleles (*_ and *_). Based on the genotype result this patient is predicted to be a poor metabolizer of UGT1A1 substrates. This patient may be at risk for an adverse or poor response to medications that inhibit or are inactivated by UGT1A1. Based on the genotype result, this patient is predicted to have low UGT1A1 function, which is generally indicative of Gilbert syndrome. This patient may be at high risk for toxicity from select medications that inhibit or are inactivated by UGT1A1. Please consult a clinical pharmacist for more information about how UGT1A1 metabolic status influences drug selection and dosing.	2	\N
7983659	CYP2B6	Ultrarapid Metabolizer	n/a	Normal/Routine/Low Risk	This result signifies that the patient has two copies of increased function alleles. Based on the genotype result this patient is predicted to be an ultrarapid metabolizer of CYP2B6 substrates. There is no reason to selectively adjust the dose of most medications that are metabolized by CYP2B6. Please consult a clinical pharmacist for more information about how CYP2B6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.011284955, "European": 0.0016704409, "Oceanian": 0.0, "East Asian": 0.007088209, "Near Eastern": 0.010816, "Central/South Asian": 0.009801, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": 0.000106068765}
7988752	CYP2D6	Ultrarapid Metabolizer	2.5	Abnormal/Priority/High Risk	This result signifies that this patient has [X copies of a normal function allele (*_xN)] [X copies of a decreased function allele (*_)]. Based on the genotype result this patient is predicted to be an ultrarapid metabolizer of CYP2D6 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2D6. To avoid an untoward drug response, dose adjustments may be necessary for medications metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.0022434974, "American": 0.0005345896, "European": 0.0003203256, "Oceanian": 0.00024761492, "East Asian": 0.00034846712, "Near Eastern": 0.005864233, "Central/South Asian": 0.00006554563, "Sub-Saharan African": 0.015329994, "African American/Afro-Caribbean": 0.01435911}
7985070	CYP2C19	Likely Poor Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a decreased function allele and one copy of a no function allele. Based on the genotype result this patient MAY be a poor metabolizer of CYP2C19 substrates. This patient may be at a high risk for an adverse or poor response to medications that are metabolized by CYP2C19. To avoid an untoward drug response, dose adjustments or or alternative therapy may be necessary for medications metabolized by the CYP2C19. Please consult a clinical pharmacist for more information about how CYP2C19 metabolic status influences drug selection and dosing.	3	{"Latino": 0.0004440685, "American": 0.0, "European": 0.00020405183, "Oceanian": 0.0, "East Asian": 0.0004349198, "Near Eastern": 0.0, "Central/South Asian": 0.0, "Sub-Saharan African": 0.010332189, "African American/Afro-Caribbean": 0.007090685}
7984971	CYP2C19	Intermediate Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a normal function allele and one copy of a no function allele OR one copy of an increased function and one copy of a no function allele. Based on the genotype result this patient is predicted to be an intermediate metabolizer of CYP2C19 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2C19. To avoid an untoward drug response, dose adjustments or alternative therapeutic agents may be necessary for medications metabolized by CYP2C19. Please consult a clinical pharmacist for more information about how CYP2C19 metabolic status influences drug selection and dosing.	3	{"Latino": 0.19035932, "American": 0.21383229, "European": 0.26108757, "Oceanian": 0.36902928, "East Asian": 0.45928204, "Near Eastern": 0.2354828, "Central/South Asian": 0.40806636, "Sub-Saharan African": 0.29945874, "African American/Afro-Caribbean": 0.31398684}
7985144	CYP2C19	Poor Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has two copies of a no function allele. Based on the genotype result this patient is predicted to be a poor metabolizer of CYP2C19 substrates. This patient may be at a high risk for an adverse or poor response to medications that are metabolized by CYP2C19. To avoid an untoward drug response, dose adjustments or or alternative therapy may be necessary for medications metabolized by the CYP2C19. Please consult a clinical pharmacist for more information about how CYP2C19 metabolic status influences drug selection and dosing.	3	{"Latino": 0.011408395, "American": 0.014819587, "European": 0.02387743, "Oceanian": 0.5713864, "East Asian": 0.12978691, "Near Eastern": 0.018584846, "Central/South Asian": 0.08156806, "Sub-Saharan African": 0.036714304, "African American/Afro-Caribbean": 0.040512204}
7985224	CYP2C19	Indeterminate	n/a	none	This result signifies that the patient has an allele combination with uncertain and/or unknown function alleles. The expected phenotype for this patient cannot be determined currently based on the CYP2C19 diplotype result. Please consult a clinical pharmacist for more specific information about how CYP2C19 function influences drug dosing.	3	{"Latino": 0.0, "American": 0.0, "European": 0.0, "Oceanian": 0.0, "East Asian": 0.0034064606, "Near Eastern": 0.0, "Central/South Asian": 0.0, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": 0.0022393465}
7984868	CYP2C19	Normal Metabolizer	n/a	Normal/Routine/Low Risk	This result signifies that the patient has two copies of a normal function allele. Based on the genotype result this patient is predicted to be an normal metabolizer of CYP2C19 substrates. There is no reason to selectively adjust the dose of most medications that are metabolized by CYP2C19. Please consult a clinical pharmacist for more information about how CYP2C19 metabolic status influences drug selection and dosing.	3	{"Latino": 0.5249766, "American": 0.62755567, "European": 0.39611652, "Oceanian": 0.035006005, "East Asian": 0.38055435, "Near Eastern": 0.45192146, "Central/South Asian": 0.29552925, "Sub-Saharan African": 0.36977687, "African American/Afro-Caribbean": 0.32805592}
7984859	CYP2C19	Rapid Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a normal function allele and one copy of an increased function allele. Based on the genotype result this patient is predicted to be a rapid metabolizer of CYP2C19 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2C19. To avoid an untoward drug response, dose adjustments or alternative therapeutic agents may be necessary for medications metabolized by CYP2C19. Please consult a clinical pharmacist for more information about how CYP2C19 metabolic status influences drug selection and dosing.	3	{"Latino": 0.24136075, "American": 0.13638271, "European": 0.2711846, "Oceanian": 0.021329276, "East Asian": 0.025343522, "Near Eastern": 0.2573682, "Central/South Asian": 0.18567303, "Sub-Saharan African": 0.21080859, "African American/Afro-Caribbean": 0.2373838}
7989193	CYP2D6	Normal Metabolizer	1.75	Normal/Routine/ Low Risk	This result signifies that this patient has three copies of *41 (*41x3) and one copy of a normal function allele (*_) or [2 copies of a decreased function allele with an activity value of 0.5 (*_x2)]. Based on the genotype result this patient is predicted to be a normal metabolizer of CYP2D6 substrates. There is no reason to selectively adjust the dose of most medications that are metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.0, "American": 0.0, "European": 0.0, "Oceanian": 0.0, "East Asian": 0.0, "Near Eastern": 0.0, "Central/South Asian": 0.0, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": 0.0}
7989211	CYP2D6	Normal Metabolizer	1.25	Normal/Routine/ Low Risk	This result signifies that this patient has [1 copy of a normal function allele (*_)] or [2 copies of a decreased function allele with an activity value of 0.5 (*_x2)] and [1 copy of a decreased function allele with an activity value of 0.25 (*_)] OR *41x3 and [1 copy of a decreased function allele with an activity value of 0.5 (*_)] or [2 copies of a decreased function allele with an activity value of 0.25 (*_x2)]. Based on the genotype result this patient is predicted to be a normal metabolizer of CYP2D6 substrates. There is no reason to selectively adjust the dose of most medications that are metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.11888533, "American": 0.07351474, "European": 0.15507403, "Oceanian": 0.12359433, "East Asian": 0.3547828, "Near Eastern": 0.22410923, "Central/South Asian": 0.23109229, "Sub-Saharan African": 0.073030114, "African American/Afro-Caribbean": 0.07348749}
7989226	CYP2D6	Intermediate Metabolizer	1.0	Abnormal/Priority/High Risk	This result signifies that this patient has [1 copy of a normal function allele (*_)] [X copies of a decreased function allele (*_)] [X copies of a no function allele (*_)]. Based on the genotype result this patient is predicted to be an intermediate metabolizer of CYP2D6 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2D6. To avoid an untoward drug response, dose adjustments may be necessary for medications metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.2278144, "American": 0.21460281, "European": 0.28533316, "Oceanian": 0.077126324, "East Asian": 0.070599586, "Near Eastern": 0.14959782, "Central/South Asian": 0.17827679, "Sub-Saharan African": 0.20079781, "African American/Afro-Caribbean": 0.2080644}
7985550	CYP2C9	Intermediate Metabolizer	1.5	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a normal function allele and one copy of a decreased function allele. Based on the genotype result, this patient is predicted to be a CYP2C9 intermediate metabolizer (activity score of 1.5). This patient may be at risk for an adverse response to medications that are affected by CYP2C9. Please consult a clinical pharmacist for more specific information about how CYP2C9 intermediate metabolizer status influences drug dosing.	3	{"Latino": 0.1647683, "American": 0.10592343, "European": 0.20758142, "Oceanian": 0.05599055, "East Asian": 0.052658077, "Near Eastern": 0.2097067, "Central/South Asian": 0.17885593, "Sub-Saharan African": 0.21372117, "African American/Afro-Caribbean": 0.1863267}
7985854	CYP2C9	Poor Metabolizer	0.5	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a decreased function allele and one copy of a no function allele. Based on the genotype result, this patient is predicted to be a CYP2C9 poor metabolizer. This patient may be at high risk for an adverse response to medications that are affected by CYP2C9. Please consult a clinical pharmacist for more specific information about how CYP2C9 intermediate metabolizer status influences drug dosing.	3	{"Latino": 0.007974847, "American": 0.0034911723, "European": 0.019907156, "Oceanian": 0.0009130932, "East Asian": 0.0030826868, "Near Eastern": 0.022547128, "Central/South Asian": 0.025517693, "Sub-Saharan African": 0.0049882242, "African American/Afro-Caribbean": 0.004712071}
7986129	CYP2C9	Poor Metabolizer	0.0	Abnormal/Priority/High Risk	This result signifies that the patient has two copies of no function alleles. Based on the genotype result, this patient is predicted to be a CYP2C9 poor metabolizer. This patient may be at high risk for an adverse response to medications that are affected by CYP2C9. Please consult a clinical pharmacist for more specific information about how CYP2C9 intermediate metabolizer status influences drug dosing.	3	{"Latino": 0.0017415384, "American": 0.00090327376, "European": 0.0057798154, "Oceanian": 0.00024261088, "East Asian": 0.0028714235, "Near Eastern": 0.007066085, "Central/South Asian": 0.012135133, "Sub-Saharan African": 0.0003982905, "African American/Afro-Caribbean": 0.00048520204}
7986222	CYP2C9	Indeterminate	n/a	none	This result signifies that the patient has an allele combination with uncertain and/or unknown function alleles. The expected phenotype for this patient cannot be determined currently based on the CYP2C9 diplotype result. Please consult a clinical pharmacist for more specific information about how CYP2C9 function influences drug dosing.	3	{"Latino": 0.0009997501, "American": 0.0, "European": 0.00059991, "Oceanian": 0.0, "East Asian": 0.0046076896, "Near Eastern": 0.0, "Central/South Asian": 0.0037963898, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": 0.0}
7988439	CYP2D6	Ultrarapid Metabolizer	≥4.0	Abnormal/Priority/High Risk	This result signifies that this patient has [X copies of a normal function allele (*_xN)] [X copies of a decreased function allele (*_)] [X copies of a no function allele (*_)]. Based on the genotype result this patient is predicted to be an ultrarapid metabolizer of CYP2D6 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2D6. To avoid an untoward drug response, dose adjustments may be necessary for medications metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.0012809848, "American": 0.0015109289, "European": 0.0018874556, "Oceanian": 0.0, "East Asian": 0.0007779561, "Near Eastern": 0.0, "Central/South Asian": 0.0, "Sub-Saharan African": 0.0038317435, "African American/Afro-Caribbean": 0.0}
7988435	CYP2D6	Ultrarapid Metabolizer	≥3.75	Abnormal/Priority/High Risk	This result signifies that this patient has [X copies of a normal function allele (*_xN)] [X copies of a decreased function allele (*_)] [X copies of a no function allele (*_)]. Based on the genotype result this patient is predicted to be an ultrarapid metabolizer of CYP2D6 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2D6. To avoid an untoward drug response, dose adjustments may be necessary for medications metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.0, "American": 0.0, "European": 0.0, "Oceanian": 0.0, "East Asian": 0.0, "Near Eastern": 0.0, "Central/South Asian": 0.0, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": 0.0}
7988473	CYP2D6	Ultrarapid Metabolizer	≥3.5	Abnormal/Priority/High Risk	This result signifies that this patient has [X copies of a normal function allele (*_xN)] [X copies of a decreased function allele (*_)] [X copies of a no function allele (*_)]. Based on the genotype result this patient is predicted to be an ultrarapid metabolizer of CYP2D6 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2D6. To avoid an untoward drug response, dose adjustments may be necessary for medications metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.00008051411, "American": 0.00001657463, "European": 0.000031193038, "Oceanian": 0.0, "East Asian": 0.00004386605, "Near Eastern": 0.0, "Central/South Asian": 0.0, "Sub-Saharan African": 0.0030223487, "African American/Afro-Caribbean": 0.0}
7988525	CYP2D6	Ultrarapid Metabolizer	≥3.0	Abnormal/Priority/High Risk	This result signifies that this patient has [X copies of a normal function allele (*_xN)] [X copies of a decreased function allele (*_)] [X copies of a no function allele (*_)]. Based on the genotype result this patient is predicted to be an ultrarapid metabolizer of CYP2D6 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2D6. To avoid an untoward drug response, dose adjustments may be necessary for medications metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.00035315607, "American": 0.0002839765, "European": 0.0008605249, "Oceanian": 0.0, "East Asian": 0.00018026348, "Near Eastern": 0.0, "Central/South Asian": 0.0, "Sub-Saharan African": 0.001428226, "African American/Afro-Caribbean": 0.0}
7993218	CYP2D6	Indeterminate	n/a	none	This result signifies that the patient has an allele combination with uncertain and/or unknown function alleles. The expected phenotype for this patient cannot be determined currently based on the CYP2D6 diplotype result. Please consult a clinical pharmacist for more specific information about how CYP2D6 function influences drug dosing.	3	{"Latino": 0.041558996, "American": 0.02454997, "European": 0.03725156, "Oceanian": 0.087338224, "East Asian": 0.066782884, "Near Eastern": 0.03744279, "Central/South Asian": 0.09993659, "Sub-Saharan African": 0.09009597, "African American/Afro-Caribbean": 0.038868744}
7988654	CYP2D6	Ultrarapid Metabolizer	3.0	Abnormal/Priority/High Risk	This result signifies that this patient has [X copies of a normal function allele (*_xN)] [X copies of a decreased function allele (*_)] [X copies of a no function allele (*_)]. Based on the genotype result this patient is predicted to be an ultrarapid metabolizer of CYP2D6 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2D6. To avoid an untoward drug response, dose adjustments may be necessary for medications metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.035694193, "American": 0.048732717, "European": 0.019382542, "Oceanian": 0.16405001, "East Asian": 0.006179998, "Near Eastern": 0.06435209, "Central/South Asian": 0.014773737, "Sub-Saharan African": 0.019435417, "African American/Afro-Caribbean": 0.025694855}
7991510	CYP2D6	Intermediate Metabolizer	0.25	Abnormal/Priority/High Risk	This result signifies that this patient has one copy of a decreased function allele with an activity value of 0.25 (*_) and one copy of a no function allele (*_). Based on the genotype result this patient is predicted to be an intermediate metabolizer of CYP2D6 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2D6. To avoid an untoward drug response, dose adjustments may be necessary for medications metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.03277562, "American": 0.0138169695, "European": 0.07070104, "Oceanian": 0.010012345, "East Asian": 0.08220821, "Near Eastern": 0.06670452, "Central/South Asian": 0.060946763, "Sub-Saharan African": 0.027220901, "African American/Afro-Caribbean": 0.024385082}
8005322	CYP3A5	Intermediate Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a normal function allele and one copy of a no function allele. Patients with this genotype are expected to require higher starting tacrolimus dosing (1.5 times to 2 times the standard dose-maximum starting dose not to exceed 0.3mg/kg/day). Further dose adjustments or selection of alternative therapy may be necessary due to other clinical factors (e.g., medication interactions, or hepatic function). Please consult a clinical pharmacist for more specific dosing information.	3	{"Latino": 0.28587034, "European": 0.13722531, "East Asian": 0.37852672, "Near Eastern": 0.21414419, "Central/South Asian": 0.43994826, "Sub-Saharan African": 0.499152, "African American/Afro-Caribbean": 0.4955547}
8005327	CYP3A5	Poor Metabolizer	n/a	Normal/Routine/Low Risk	This result signifies that the patient has two copies of a no function allele. Patients with this genotype are expected to require standard tacrolimus dosing. Please consult a clinical pharmacist for more specific dosing information.	3	{"Latino": 0.68427247, "European": 0.85728335, "East Asian": 0.5571847, "Near Eastern": 0.770986, "Central/South Asian": 0.45330563, "Sub-Saharan African": 0.2710154, "African American/Afro-Caribbean": 0.2993679}
8005335	CYP3A5	Possible Intermediate Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a normal function allele and one copy of an uncertain or unknown function allele. Patients with this genotype are expected to require higher starting tacrolimus dosing (1.5 times to 2 times the standard dose-maximum starting dose not to exceed 0.3mg/kg/day). Further dose adjustments or selection of alternative therapy may be necessary due to other clinical factors (e.g., medication interactions, or hepatic function). Please consult a clinical pharmacist for more specific dosing information.	3	{"Latino": 0.0, "European": 0.0, "East Asian": 0.0, "Near Eastern": 0.0, "Central/South Asian": 0.0, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": 0.0}
7989239	CYP2D6	Intermediate Metabolizer	0.75	Abnormal/Priority/High Risk	This result signifies that this patient has has three copies of *41 (*41x3) and one copy of a no function allele (*_) OR [1 copy of a decreased function allele with an activity value of 0.25 (*_)] and [1 copy of a decreased function allele with an activity value of 0.5 (*_)] or [2 copies of a decreased function allele with an activity value of 0.25 (*_x2)] . Based on the genotype result this patient is predicted to be an intermediate metabolizer of CYP2D6 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2D6. To avoid an untoward drug response, dose adjustments may be necessary for medications metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.0074723335, "American": 0.00080644403, "European": 0.0025628314, "Oceanian": 0.00018655165, "East Asian": 0.020004882, "Near Eastern": 0.02042247, "Central/South Asian": 0.0010252715, "Sub-Saharan African": 0.05760366, "African American/Afro-Caribbean": 0.041067164}
7988416	CYP2D6	Ultrarapid Metabolizer	≥6.0	Abnormal/Priority/High Risk	This result signifies that this patient has [X copies of a normal function allele (*_xN)] [X copies of a decreased function allele (*_)] [X copies of a no function allele (*_)]. Based on the genotype result this patient is predicted to be an ultrarapid metabolizer of CYP2D6 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2D6. To avoid an untoward drug response, dose adjustments may be necessary for medications metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.0000010000001, "American": 0.0000010000001, "European": 0.0000028470035, "Oceanian": 0.0, "East Asian": 0.0000010000001, "Near Eastern": 0.0, "Central/South Asian": 0.0, "Sub-Saharan African": 0.000025000001, "African American/Afro-Caribbean": 0.0}
7988421	CYP2D6	Ultrarapid Metabolizer	≥5.0	Abnormal/Priority/High Risk	This result signifies that this patient has [X copies of a normal function allele (*_xN)] [X copies of a decreased function allele (*_)] [X copies of a no function allele (*_)]. Based on the genotype result this patient is predicted to be an ultrarapid metabolizer of CYP2D6 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2D6. To avoid an untoward drug response, dose adjustments may be necessary for medications metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.000055729302, "American": 0.00006450697, "European": 0.000058472542, "Oceanian": 0.0, "East Asian": 0.000015887783, "Near Eastern": 0.0, "Central/South Asian": 0.0, "Sub-Saharan African": 0.00025361063, "African American/Afro-Caribbean": 0.0}
7992040	CYP2D6	Poor Metabolizer	0.0	Abnormal/Priority/High Risk	This result signifies that the patient has two copies of a no function allele (*_/*_). Based on the genotype result this patient is predicted to be a poor metabolizer of CYP2D6 substrates. This patient may be at a high risk for an adverse or poor response to medications that are metabolized by CYP2D6. To avoid an untoward drug response, dose adjustments or alternative therapeutic agents may be necessary for medications metabolized by the CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.0311798, "American": 0.020160662, "European": 0.065024786, "Oceanian": 0.0031239481, "East Asian": 0.008123729, "Near Eastern": 0.021957064, "Central/South Asian": 0.023507897, "Sub-Saharan African": 0.020398295, "African American/Afro-Caribbean": 0.023474354}
8005339	CYP3A5	Indeterminate	n/a	none	This result signifies that the patient has an allele combination with uncertain and/or unknown function alleles. The expected phenotype for this patient cannot be determined currently based on the CYP3A5 diplotype result. Please consult a clinical pharmacist for more specific information about how CYP3A5 function influences drug dosing.	3	{"Latino": 0.0, "European": 0.0, "East Asian": 0.0, "Near Eastern": 0.0, "Central/South Asian": 0.0, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": 0.0}
8005351	DPYD	Normal Metabolizer	2.0	Normal/Routine/Low Risk	This result signifies that the patient has two copies of normal function DPYD alleles. Based on the genotype result this patient is predicted to be DPYD Normal Metabolizer with a DPYD activity score of 2. For this genotype, no selective dose adjustment is indicated for medications that are metabolized by DPD. Please consult a clinical pharmacist for more information about how DPD metabolic status influences drug selection and dosing.	2	\N
8006949	DPYD	Intermediate Metabolizer	1.5	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a normal function allele and one copy of a decreased function allele of the DPYD gene. Based on the genotype result this patient is predicted to be a DPYD Intermediate Metabolizer with a DPYD activity score of 1.5. This patient may be at risk for adverse drug reactions to medications that are metabolized by DPD (i.e. 5-fluorouracil, capecitabine, and tegafur) and a dose adjustment may be indicated. Please consult a clinical pharmacist for more information about how DPD metabolic status influences drug selection and dosing.	2	\N
8007343	DPYD	Intermediate Metabolizer	1.0	Abnormal/Priority/High Risk	This result signifies that the patient has either one copy of a normal function allele and one copy of a no function allele of the DPYD gene OR two copies of decreased function alleles of the DPYD gene. Based on the genotype result this patient is predicted to be a DPYD Intermediate Metabolizer with a DPYD activity score of 1. This patient may be at risk for adverse drug reactions to medications that are metabolized by DPD (i.e. 5-fluorouracil, capecitabine, and tegafur) and a dose adjustment may be indicated. Please consult a clinical pharmacist for more information about how DPD metabolic status influences drug selection and dosing.	2	\N
8008550	DPYD	Poor Metabolizer	0.5	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a decreased function allele and one copy of a no function allele of the DPYD gene. Based on the genotype result this patient is predicted to be a DPYD Poor Metabolizer with a DPYD activity score of 0.5. This patient may be at risk for adverse drug reactions to medications that are metabolized by DPD (i.e. 5-fluorouracil, capecitabine, and tegafur) and a dose adjustment or alternative therapeutic agents may be indicated. Please consult a clinical pharmacist for more information about how DPD metabolic status influences drug selection and dosing.	2	\N
8008699	DPYD	Poor Metabolizer	0.0	Abnormal/Priority/High Risk	This result signifies that the patient has two copies of no function alleles of the DPYD gene. Based on the genotype result this patient is predicted to be a DPYD Poor Metabolizer with a DPYD activity score of 0. This patient may be at risk for adverse drug reactions to medications that are metabolized by DPD (i.e. 5-fluorouracil, capecitabine, and tegafur) and alternative therapeutic agents may be indicated. Please consult a clinical pharmacist for more information about how DPD metabolic status influences drug selection and dosing.	2	\N
8088805	HLA-A	*31:01 negative	n/a	Routine/Low-Risk	The HLA-A*31:01 allele, which is associated with severe cutaneous adverse reactions among patients taking certain aromatic anticonvulsants, was not detected in this patient. No change in therapy is warranted based on these results. It should be noted that a negative HLA-A*31:01 result does not absolutely rule out the possibility of an adverse drug reaction. Please consult a clinical pharmacist for more information.	1	\N
8088808	HLA-A	*31:01 positive	n/a	Priority/High-Risk	This result signifies that the patient has one or two copies of HLA-A*31:01. Patients with this genotype are at increased risk of severe cutaneous adverse reactions, including Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN), drug reaction with eosinophilia and systemic symptoms (DRESS), and maculopapular exanthema (MPE), with certain aromatic anticonvulsants (e.g., carbamazepine). Alternative therapy may be warranted. Please consult a clinical pharmacist for more information.	1	\N
7988501	CYP2D6	Ultrarapid Metabolizer	≥3.25	Abnormal/Priority/High Risk	This result signifies that this patient has [X copies of a normal function allele (*_xN)] [X copies of a decreased function allele (*_)] [X copies of a no function allele (*_)]. Based on the genotype result this patient is predicted to be an ultrarapid metabolizer of CYP2D6 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2D6. To avoid an untoward drug response, dose adjustments may be necessary for medications metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.00018561553, "American": 0.00009731066, "European": 0.00046782166, "Oceanian": 0.0, "East Asian": 0.0009120896, "Near Eastern": 0.0, "Central/South Asian": 0.0, "Sub-Saharan African": 0.000952962, "African American/Afro-Caribbean": 0.0}
7988623	CYP2D6	Ultrarapid Metabolizer	4.0	Abnormal/Priority/High Risk	This result signifies that this patient has [X copies of a normal function allele (*_xN)] [X copies of a decreased function allele (*_)] [X copies of a no function allele (*_)]. Based on the genotype result this patient is predicted to be an ultrarapid metabolizer of CYP2D6 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2D6. To avoid an untoward drug response, dose adjustments may be necessary for medications metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.0007764387, "American": 0.0010402872, "European": 0.0003002313, "Oceanian": 0.014133941, "East Asian": 0.000063105406, "Near Eastern": 0.0041771694, "Central/South Asian": 0.00016144973, "Sub-Saharan African": 0.0006431835, "African American/Afro-Caribbean": 0.0007742127}
7990817	CYP2D6	Intermediate Metabolizer	0.5	Abnormal/Priority/High Risk	This result signifies that this patient has [1 copy of a decreased function allele with an activity value of 0.5 (*_)] or [2 copies of a decreased function allele with an activity value of 0.25 (*_x2)] and one copy of a no function allele (*_) OR two copies for a decreased function allele with an activity value of 0.25 (*_/*_). Based on the genotype result this patient is predicted to be an intermediate metabolizer of CYP2D6 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2D6. To avoid an untoward drug response, dose adjustments may be necessary for medications metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.022830304, "American": 0.0047207433, "European": 0.023932345, "Oceanian": 0.008138877, "East Asian": 0.21193053, "Near Eastern": 0.06410619, "Central/South Asian": 0.040293686, "Sub-Saharan African": 0.0954133, "African American/Afro-Caribbean": 0.08539959}
8008939	G6PD	Deficient	n/a	Abnormal/Priority/High Risk	Based on the genotype result, this patient is predicted to be G6PD deficient and is at risk for developing hemolytic anemia when exposed to certain medications (such as dapsone, methylene blue, pegloticase, primaquine (at certain doses), rasburicase, tafenoquine, toluidine blue) or foods (such as fava beans). Please consult a clinical pharmacist for more information.	2	\N
8009032	G6PD	Deficient with CNSHA	n/a	Abnormal/Priority/High Risk	Based on the genotype result, this patient is predicted to be G6PD deficient with CNSHA and is at risk for developing or worsening hemolytic anemia when exposed to certain medications (such as dapsone, methylene blue, pegloticase, primaquine (at certain doses), rasburicase, tafenoquine, toluidine blue) or foods (such as fava beans). Please consult a clinical pharmacist for more information.	2	\N
8025602	G6PD	Indeterminate	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has an allele combination with uncertain and/or unknown function alleles. The expected phenotype for this patient cannot be determined currently based on genotype alone. A G6PD enzyme activity test is recommended to assess for G6PD deficiency. Please consult a clinical pharmacist for more specific information about how G6PD function influences drug dosing.	2	\N
8008932	G6PD	Normal	n/a	Normal Risk	Based on the genotype result, this patient is predicted to have normal G6PD enzyme activity. This means there is no reason to selectively avoid G6PD associated medications based on the G6PD status alone. Please consult a clinical pharmacist for more information.	2	\N
8009136	G6PD	Variable	n/a	Abnormal/Priority/High Risk	This patient carries one copy of a deficient G6PD allele and one copy of a normal G6PD allele. Due to X inactivation, patients who are heterozygous with one deficient allele and one normal allele may exhibit G6PD activity ranging from normal to deficient. A G6PD enzyme activity test is recommended to assess for G6PD deficiency. Please consult a clinical pharmacist for more information.	2	\N
8088811	HLA-B	*15:02 negative	n/a	Routine/Low-Risk	The HLA-B*15:02 allele, which is associated with severe cutaneous adverse reactions among patients taking certain aromatic anticonvulsants, was not detected in this patient. No change in therapy is warranted based on these results. It should be noted that a negative HLA-B*15:02 result does not absolutely rule out the possibility of an adverse drug reaction. Please consult a clinical pharmacist for more information.	1	\N
8088814	HLA-B	*15:02 positive	n/a	Priority/High-Risk	This result signifies that the patient has one or two copies of HLA-B*15:02. Patients with this genotype are at increased risk of severe cutaneous adverse reactions, including Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN), with certain aromatic anticonvulsants (e.g., carbamazepine, oxcarbazepine, phenytoin/fosphenytoin). Alternative therapy may be warranted. Please consult a clinical pharmacist for more information.	1	\N
8088817	HLA-B	*57:01 negative	n/a	Normal/Routine/Low Risk	The HLA-B*57:01 allele, associated with abacavir hypersensitivity, was not detected in this patient. The patient may be prescribed abacavir. Please refer to the hospital formulary guidelines for specific dosing information. It should be noted that a negative HLA-B*57:01 result does not absolutely rule out the possibility of some form of abacavir hypersensitivity. Administration of abacavir therapy requires close observation including immediate discontinuation of therapy should any signs or symptoms of hypersensitivity develop.	1	\N
8088820	HLA-B	*57:01 positive	n/a	Abnormal/Priority/High Risk	The HLA-B*57:01 allele, associated with abacavir hypersensitivity, was detected in this patient. HLA-B*5701 positive patients should NOT be prescribed abacavir.	1	\N
8088823	HLA-B	*58:01 negative	n/a	Normal/Routine/Low Risk	The HLA-B*58:01 allele, associated with allopurinol hypersensitivity, was not detected in this patient. Allopurinol can be used per standard dosing guidelines. Patients should be monitored closely for any signs of sensitivity reactions, especially those patients receiving allopurinol (of >300 mg/day), concomitant medications (i.e. thiazide diuretics or penicillin/cephalosporin) or with medical conditions (i.e. chronic kidney disease) that increase the non-genetic risk for allopurinol-related hypersensitivity reactions.	1	\N
8088826	HLA-B	*58:01 positive	n/a	Abnormal/Priority/High Risk	The HLA-B*58:01 allele, associated with allopurinol hypersensitivity, was detected in this patient. Allopurinol is contraindicated.	1	\N
8005319	CYP3A5	Normal Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has two copies of a normal function allele. Patients with this genotype are expected to require higher starting tacrolimus dosing (1.5 times to 2 times the standard dose-maximum starting dose not to exceed 0.3mg/kg/day). Further dose adjustments or selection of alternative therapy may be necessary due to other clinical factors (e.g., medication interactions, or hepatic function). Please consult a clinical pharmacist for more specific dosing information.	3	{"Latino": 0.029857205, "European": 0.005491413, "East Asian": 0.064288594, "Near Eastern": 0.014869832, "Central/South Asian": 0.106746115, "Sub-Saharan African": 0.22983262, "African American/Afro-Caribbean": 0.20507748}
8026722	MT-RNR1	increased risk of aminoglycoside-induced hearing loss	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has a copy of the MT-RNR1 [variant]. Based on this genotype result, the patient is predicted to be at increased risk of aminoglycoside-induced hearing loss. This means that the patient is likely to develop irreversible hearing loss if aminoglycosides (e.g. amikacin, gentamicin, tobramycin) are prescribed. Please consult a clinical pharmacist or Infectious Diseases Service for help selecting alternative therapies.	2	\N
8026727	MT-RNR1	normal risk of aminoglycoside-induced hearing loss	n/a	Normal/Routine/Low Risk	This result signifies that MT-RNR1 variants associated with aminoglycoside-induced hearing loss were not detected in this patient. Based on this genotype result, no change in aminoglycoside therapy is warranted. It should be noted that this result does not absolutely rule out the possibility of the patient developing ototoxicity with aminoglycoside use.	2	\N
8026730	MT-RNR1	uncertain risk of aminoglycoside-induced hearing loss	n/a	Normal/Routine/Low Risk	This result signifies that the patient has a copy of MT-RNR1 [variant]. At this time, the association of this allele with aminoglycoside-induced hearing loss is unknown/uncertain. Based on this genotype result, no change in aminoglycoside therapy is warranted. It should be noted that this result does not absolutely rule out the possibility of the patient developing ototoxicity with aminoglycoside use.	2	\N
7983693	CYP2B6	Intermediate Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a normal function allele and one copy of a no function allele OR one copy of a normal function allele and one copy of a decreased function allele OR one copy of an increased function allele and one copy of a no function allele OR one copy of an increased function allele and one copy of a decreased function allele. Based on the genotype result this patient is predicted to be an intermediate metabolizer of CYP2B6 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2B6. To avoid an untoward drug response, dose adjustments or alternative therapeutic agents may be necessary for medications metabolized by CYP2B6. Please consult a clinical pharmacist for more information about how CYP2B6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.42165288, "European": 0.37952113, "Oceanian": 0.46080005, "East Asian": 0.32628936, "Near Eastern": 0.459102, "Central/South Asian": 0.36526063, "Sub-Saharan African": 0.36808127, "African American/Afro-Caribbean": 0.4660738}
8028559	NUDT15	Possible Intermediate Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of an uncertain function allele and one copy of a no function allele. Based on the genotype result this patient is predicted to be a NUDT15 possible intermediate metabolizer. This patient may be at risk for an adverse reactions to medications that are metabolized by NUDT15 (eg thiopurines). To avoid an untoward drug response, dose adjustments or alternative therapeutic agents may be necessary for medications metabolized by NUDT15. Please consult a clinical pharmacist for more information about how NUDT15 metabolic status influences drug selection and dosing.	3	{"Latino": 0.0, "European": 0.0, "East Asian": 0.0, "Central/South Asian": 0.0}
8026752	NAT2	Rapid Metabolizer	n/a	Priority/High Risk	This result signifies that the patient has inherited two increased function alleles. Based on the genotype result this patient is predicted to be a rapid metabolizer of NAT2 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by NAT2. To avoid an untoward drug response, dose adjustments or alternative therapeutic agents may be necessary for medications metabolized by NAT2. Please consult a clinical pharmacist for more information about how NAT2 metabolic status influences drug selection and dosing.	2	\N
8026757	NAT2	Intermediate Metabolizer	n/a	Priority/High Risk	This result signifies that the patient has inherited one increased function allele and one decreased function allele. Based on the genotype result this patient is predicted to be an intermediate metabolizer of NAT2 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by NAT2. To avoid an untoward drug response, dose adjustments or alternative therapeutic agents may be necessary for medications metabolized by NAT2. Please consult a clinical pharmacist for more information about how NAT2 metabolic status influences drug selection and dosing.	2	\N
8026839	NAT2	Poor Metabolizer	n/a	Priority/High Risk	This result signifies that the patient has inherited two decreased function alleles. Based on the genotype result this patient is predicted to be a poor metabolizer of NAT2 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by NAT2. To avoid an untoward drug response, dose adjustments or alternative therapeutic agents may be necessary for medications metabolized by NAT2. Please consult a clinical pharmacist for more information about how NAT2 metabolic status influences drug selection and dosing.	2	\N
8027661	NAT2	Indeterminate	n/a	none	This result signifies that the patient has inhertied an allele combination with uncertain and/or unknown function alleles. The expected phenotype for this patient cannot be determined currently based on the NAT2 diplotype result. Please consult a clinical pharmacist for more specific information about how NAT2 function influences drug dosing.	2	\N
7984856	CYP2C19	Ultrarapid Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has two copies of an increased function allele. Based on the genotype result this patient is predicted to be an ultrarapid metabolizer of CYP2C19 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2C19. To avoid an untoward drug response, dose adjustments or alternative therapeutic agents may be necessary for medications metabolized by CYP2C19. Please consult a clinical pharmacist for more information about how CYP2C19 metabolic status influences drug selection and dosing.	3	{"Latino": 0.02774172, "American": 0.0074097984, "European": 0.04641379, "Oceanian": 0.003249, "East Asian": 0.00042194634, "Near Eastern": 0.036642652, "Central/South Asian": 0.029163336, "Sub-Saharan African": 0.030045323, "African American/Afro-Caribbean": 0.042943195}
7984898	CYP2C19	Likely Intermediate Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a normal function allele and one copy of a decreased function allele OR one copy of an increased function allele and one copy of a decreased function allele OR two copies of a decreased function allele. Based on the genotype result this patient MAY be an intermediate metabolizer of CYP2C19 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2C19. To avoid an untoward drug response, dose adjustments or alternative therapeutic agents may be necessary for medications metabolized by CYP2C19. Please consult a clinical pharmacist for more information about how CYP2C19 metabolic status influences drug selection and dosing.	3	{"Latino": 0.003709162, "American": 0.0, "European": 0.0011160374, "Oceanian": 0.0, "East Asian": 0.00076989824, "Near Eastern": 0.0, "Central/South Asian": 0.0, "Sub-Saharan African": 0.042863965, "African American/Afro-Caribbean": 0.027788177}
8088629	TPMT	Normal Metabolizer	n/a	Normal/Routine/Low Risk	This result signifies that the patient has two copies of a normal function allele OR one copy of a normal function allele and one copy of a decreased function allele. Based on the genotype result this patient is predicted to be a TPMT normal metabolizer. There is no reason to selectively adjust the dose of most medications that are metabolized by TPMT. However, thiopurines can be affected by a patient's TPMT and NUDT15 phenotype. Please consult a clinical pharmacist for more information about how TPMT and NUDT15 metabolic status influences drug selection and dosing.	3	{"Latino": 0.8923553, "European": 0.90923065, "East Asian": 0.9596651, "Near Eastern": 0.93240434, "Central/South Asian": 0.96327126, "Sub-Saharan African": 0.8933782, "African American/Afro-Caribbean": 0.8646596}
8087501	TPMT	Possible Intermediate Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of an uncertain or unknown function allele and one copy of a no function allele OR one copy of a no function allele and one copy of a decreased function allele. Based on the genotype result this patient has a priority result (TPMT possible intermediate metabolizer) because their activity is not likely to be any higher than that of an intermediate metabolizer; if the uncertain/unknown function allele is also low, activity may be even lower than that of an intermediate metabolizer. This patient may be at risk for an adverse reactions to medications that are metabolized by TPMT (eg. thiopurines). To avoid an untoward drug response, dose adjustments or alternative therapeutic agents may be necessary for medications metabolized by TPMT. However, thiopurines can be affected by a patient's TPMT and NUDT15 phenotype. Please consult a clinical pharmacist for more information about how TPMT and NUDT15metabolic status influences drug selection and dosing.	3	{"Latino": 0.00018168772, "European": 0.000062770196, "East Asian": 0.0000021581852, "Near Eastern": 0.0, "Central/South Asian": 0.0, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": 0.0024473174}
7978180	ABCG2	Normal Function	n/a	Normal/Routine/Low Risk	This result signifies that the patient has two copies of a normal function allele. Based on the genotype result, this patient is predicted to have normal ABCG2 function. This means that there is no reason to adjust the dose of most medications that are affected by ABCG2 on the basis of ABCG2 genetic status. Please consult a clinical pharmacist for more specific information about how ABCG2 function influences drug dosing.	3	{"Latino": 0.6015554, "American": 0.64000005, "European": 0.8035329, "Oceanian": 0.63246274, "East Asian": 0.4801104, "Near Eastern": 0.87366414, "Central/South Asian": 0.8222862, "Sub-Saharan African": 0.9883421, "African American/Afro-Caribbean": 0.9314832}
8028536	NUDT15	Normal Metabolizer	n/a	Normal/Routine/Low Risk	This result signifies that the patient has two copies of a normal function allele OR one copy of a normal function allele and one copy of a decreased function allele. Based on the genotype result this patient is predicted to be a NUDT15 normal metabolizer. There is no reason to selectively adjust the dose of most medications that are metabolized by NUDT15. Please consult a clinical pharmacist for more information about how NUDT15 metabolic status influences drug selection and dosing.	3	{"Latino": 0.94649667, "European": 0.98632336, "East Asian": 0.8551724, "Central/South Asian": 0.8657786}
7985545	CYP2C9	Normal Metabolizer	2.0	Normal/Routine/Low Risk	This result signifies that the patient has two copies of a normal function allele. Based on the genotype result, this patient is predicted to be a CYP2C9 Normal metabolizer. Based only on the CYP2C9 genotype, there is no reason to adjust the dose of most medications that are affected by CYP2C9. Please consult a clinical pharmacist for more specific information about how CYP2C9 function influences drug dosing.	3	{"Latino": 0.74342215, "American": 0.83149743, "European": 0.62845254, "Oceanian": 0.9122409, "East Asian": 0.8378542, "Near Eastern": 0.61125296, "Central/South Asian": 0.5961676, "Sub-Saharan African": 0.73114437, "African American/Afro-Caribbean": 0.75866354}
8028542	NUDT15	Intermediate Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a normal function allele and one copy of a no function allele OR two copies of a decreased function allele. Based on the genotype result this patient is predicted to be a NUDT15 intermediate metabolizer. This patient may be at risk for an adverse reactions to medications that are metabolized by NUDT15 (eg thiopurines). To avoid an untoward drug response, dose adjustments or alternative therapeutic agents may be necessary for medications metabolized by NUDT15. Please consult a clinical pharmacist for more information about how NUDT15 metabolic status influences drug selection and dosing.	3	{"Latino": 0.0527679, "European": 0.013629507, "East Asian": 0.13750981, "Central/South Asian": 0.12932494}
8028627	NUDT15	Poor Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has two copies of a no function allele OR one copy of a no function allele and one copy of a decreased function allele. Based on the genotype result this patient is predicted to be a NUDT15 poor metabolizer. This patient may be at a high risk for an adverse reactions to medications that are metabolized by NUDT15 (eg. thiopurines). To avoid an untoward drug response, dose adjustments or or alternative therapy may be necessary for medications metabolized by NUDT15. Please consult a clinical pharmacist for more information about how NUDT15 metabolic status influences drug selection and dosing.	3	{"Latino": 0.00073546247, "European": 0.000047192545, "East Asian": 0.0073177223, "Central/South Asian": 0.004896416}
8028718	NUDT15	Indeterminate	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a normal function allele and one copy of an uncertain function allele OR one copy of a decreased function allele and one copy of an uncertain function allele OR two copies of an uncertain function allele. The expected phenotype for this patient cannot be determined currently based on the NUDT15 diplotype result. If thiopurines are required and NUDT15 status is unknown, monitor closely for toxicity. Please consult a clinical pharmacist for more specific information about how NUDT15 function influences drug dosing.	3	{"Latino": 0.0, "European": 0.0, "East Asian": 0.0, "Central/South Asian": 0.0}
7978174	ABCG2	Poor Function	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has two copies of a decreased function allele. Based on the genotype result, this patient is predicted to have poor ABCG2 function. This patient may be at a high risk for an adverse response to medications that are affected by ABCG2 (i.e. statins). To avoid an untoward drug response, dose adjustments or alternative therapeutic agents may be necessary for medications affected by ABCG2. Please consult a clinical pharmacist for more specific information about how ABCG2 function influences drug dosing.	3	{"Latino": 0.05035536, "American": 0.040000003, "European": 0.010732961, "Oceanian": 0.0419122, "East Asian": 0.09431041, "Near Eastern": 0.00426409, "Central/South Asian": 0.00868624, "Sub-Saharan African": 0.000034175762, "African American/Afro-Caribbean": 0.0012156549}
7978177	ABCG2	Decreased Function	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a normal function allele and one copy of a no decreased allele . Based on the genotype result, this patient is predicted to have decreased ABCG2 function. This patient may be at risk for an adverse response to medications that are affected by ABCG2. To avoid an untoward drug response, dose adjustments may be necessary for medications affected by ABCG2 (i.e. statins). Please consult a clinical pharmacist for more specific information about how ABCG2 function influences drug dosing.	3	{"Latino": 0.34808928, "American": 0.32000002, "European": 0.18573408, "Oceanian": 0.32562497, "East Asian": 0.4255792, "Near Eastern": 0.122071825, "Central/South Asian": 0.1690275, "Sub-Saharan African": 0.011623656, "African American/Afro-Caribbean": 0.06730118}
7978183	CACNA1S	Malignant Hyperthermia Susceptibility	n/a	Abnormal/Priority/High Risk	This result signifies that this patient has one copy of a variant [variant] associated with malignant hyperthermia susceptibility. Halogenated volatile anesthetics or depolarizing muscle relaxants are relatively contraindicated in persons with MHS. They should not be used, except in extraordinary circumstances where the benefits outweigh the risks. Please consult a MHS specialist or contact MHAUS (https://www.mhaus.org/healthcare-professionals/) for further information.	2	\N
7978191	CACNA1S	Uncertain Susceptibility	n/a	Normal Risk	Variation in RYR1 and/or CACNA1S genes is associated with increased risk of Malignant hyperthermia after administration of depolarizing muscle relaxants and potent volatile anesthetics. Although listed causative CACNA1S variants were NOT detected in this patient, it should be noted that this finding does not absolutely rule out the possibility of malignant hyperthermia. These results should be interpreted in the context of other genetic and clinical findings, family history and other laboratory data.	2	\N
8060391	RYR1	Malignant Hyperthermia Susceptibility	n/a	Abnormal/Priority/High Risk	This result signifies that this patient has one copy of a variant [variant] associated with malignant hyperthermia susceptibility. Halogenated volatile anesthetics or depolarizing muscle relaxants are relatively contraindicated in persons with MHS. They should not be used, except in extraordinary circumstances where the benefits outweigh the risks. Please consult a MHS specialist or contact MHAUS (https://www.mhaus.org/healthcare-professionals/) for further information.	2	\N
8028761	RYR1	Uncertain Susceptibility	n/a	Normal Risk	Variation in RYR1 and/or CACNA1S genes is associated with increased risk of Malignant hyperthermia after administration of depolarizing muscle relaxants and potent volatile anesthetics. Although listed causative RYR1 variants were NOT detected in this patient, it should be noted that this finding does not absolutely rule out the possibility of malignant hyperthermia. These results should be interpreted in the context of other genetic and clinical findings, family history and other laboratory data.	2	\N
7985594	CYP2C9	Intermediate Metabolizer	1.0	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a normal function allele and one copy of a no function allele OR two copies of decreased function alleles. Based on the genotype result, this patient is predicted to be a CYP2C9 intermediate metabolizer (activity score of 1). This patient may be at risk for an adverse response to medications that are affected by CYP2C9. Please consult a clinical pharmacist for more specific information about how CYP2C9 intermediate metabolizer status influences drug dosing.	3	{"Latino": 0.08109343, "American": 0.05818467, "European": 0.13767911, "Oceanian": 0.03061276, "East Asian": 0.098925985, "Near Eastern": 0.1494271, "Central/South Asian": 0.18352722, "Sub-Saharan African": 0.049747862, "African American/Afro-Caribbean": 0.049812526}
7978194	CFTR	ivacaftor responsive in CF patients	n/a	\N	\N	1	\N
8086918	SLCO1B1	Possible Decreased Function	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a uncertain or unknown function allele (*_) and one copy of a no function allele (*_). Based on the genotype result, this patient is predicted to have possible decreased SLCO1B1 function. This patient may be at risk for an adverse response to medications that are affected by SLCO1B1. To avoid an untoward drug response, dose adjustments may be necessary for medications affected by SLCO1B1 (i.e. statins). Please consult a clinical pharmacist for more specific information about how SLCO1B1 function influences drug dosing.	3	{"American": 0.0, "European": 0.00026362084, "Oceanian": 0.0, "East Asian": 0.0011306308, "Near Eastern": 0.0, "Central/South Asian": 0.0000418451, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": 0.0}
8086744	SLCO1B1	Decreased Function	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a normal function allele (*_) and one copy of a no function allele (*_). Based on the genotype result, this patient is predicted to have decreased SLCO1B1 function. This patient may be at risk for an adverse response to medications that are affected by SLCO1B1. To avoid an untoward drug response, dose adjustments may be necessary for medications affected by SLCO1B1 (i.e. statins). Please consult a clinical pharmacist for more specific information about how SLCO1B1 function influences drug dosing.	3	{"American": 0.3648, "European": 0.28296122, "Oceanian": 0.0, "East Asian": 0.21842287, "Near Eastern": 0.32000002, "Central/South Asian": 0.12971397, "Sub-Saharan African": 0.054308295, "African American/Afro-Caribbean": 0.0198}
8086739	SLCO1B1	Increased Function	n/a	Normal/Routine/Low Risk	This result signifies that the patient has two copies of an increased function allele. Based on the genotype result, this patient is predicted to have increased SLCO1B1 function. This means that there is no reason to adjust the dose of most medications that are affected by SLCO1B1 on the basis of SLCO1B1 genetic status at this time. Please consult a clinical pharmacist for more specific information about how SLCO1B1 function influences drug dosing.	3	{"American": 0.0, "European": 0.029916462, "Oceanian": 0.0, "East Asian": 0.0, "Near Eastern": 0.0, "Central/South Asian": 0.0, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": 0.0}
8086774	SLCO1B1	Indeterminate	n/a	none	This result signifies that the patient has an allele combination with unknown or uncertain function alleles. The expected phenotype for this patient cannot be determined currently based on the SLCO1B1 diplotype result. Please consult a clinical pharmacist for more specific information about how SLCO1B1 function influences drug dosing.	3	{"American": 0.0, "European": 0.001279436, "Oceanian": 0.0, "East Asian": 0.007855513, "Near Eastern": 0.0, "Central/South Asian": 0.0005580649, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": 0.0}
8086768	SLCO1B1	Normal Function	n/a	Normal/Routine/Low Risk	This result signifies that the patient has two copies of a normal function allele. Based on the genotype result, this patient is predicted to have normal SLCO1B1 function. This means that there is no reason to adjust the dose of most medications that are affected by SLCO1B1 on the basis of SLCO1B1 genetic status. Please consult a clinical pharmacist for more specific information about how SLCO1B1 function influences drug dosing.	3	{"American": 0.5776, "European": 0.6564144, "Oceanian": 1.0, "East Asian": 0.75683165, "Near Eastern": 0.64000005, "Central/South Asian": 0.8648222, "Sub-Saharan African": 0.94491136, "African American/Afro-Caribbean": 0.98010004}
8086823	SLCO1B1	Poor Function	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has two copies of a no function allele. Based on the genotype result, this patient is predicted to have low SLCO1B1 function. This patient may be at a high risk for an adverse response to medications that are affected by SLCO1B1 (i.e. statins). To avoid an untoward drug response, dose adjustments or alternative therapeutic agents may be necessary for medications affected by SLCO1B1. Please consult a clinical pharmacist for more specific information about how SLCO1B1 function influences drug dosing.	3	{"American": 0.0576, "European": 0.02916489, "Oceanian": 0.0, "East Asian": 0.015759302, "Near Eastern": 0.040000003, "Central/South Asian": 0.004863923, "Sub-Saharan African": 0.0007803353, "African American/Afro-Caribbean": 0.00010}
\.


--
-- Data for Name: gene_result_diplotype; Type: TABLE DATA; Schema: cpic; Owner: -
--

COPY cpic.gene_result_diplotype (id, functionphenotypeid, diplotype, diplotypekey, frequency) FROM stdin;
7984111	7984110	*4/*11	{"CYP2B6": {"*4": 1, "*11": 1}}	{"Latino": 0.0003571671, "European": 0.0002463573, "Oceanian": null, "East Asian": 0.0, "Near Eastern": null, "Central/South Asian": 0.00043431963, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": 0.000050804247}
7989508	7989426	*9x2/*13+*2	{"CYP2D6": {"*9x2": 1, "*13+*2": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7989509	7989426	*9x2/*13+*1	{"CYP2D6": {"*9x2": 1, "*13+*1": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7989510	7989426	*13+*1/*54	{"CYP2D6": {"*54": 1, "*13+*1": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7989511	7989426	*13+*1/*55	{"CYP2D6": {"*55": 1, "*13+*1": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7989512	7989426	*1/*14	{"CYP2D6": {"*1": 1, "*14": 1}}	{"Latino": 0.0, "American": 0.0, "European": 0.0, "Oceanian": 0.0, "East Asian": 0.0023903432, "Near Eastern": null, "Central/South Asian": 0.0, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": 0.0}
7989513	7989426	*13+*1/*50	{"CYP2D6": {"*50": 1, "*13+*1": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7989514	7989426	*29x2/*41x2	{"CYP2D6": {"*29x2": 1, "*41x2": 1}}	{"Latino": 0.00000003110168, "American": 0.0, "European": 0.0, "Oceanian": null, "East Asian": 0.0, "Near Eastern": null, "Central/South Asian": 0.0, "Sub-Saharan African": 0.0000025322554, "African American/Afro-Caribbean": 0.0000013091071}
7989515	7989426	*33/*50	{"CYP2D6": {"*33": 1, "*50": 1}}	{"Latino": null, "American": null, "European": 0.0, "Oceanian": null, "East Asian": 0.00000017051144, "Near Eastern": 0.0, "Central/South Asian": null, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": null}
7989516	7989426	*59/*68+*2	{"CYP2D6": {"*59": 1, "*68+*2": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7989517	7989426	*1/*17	{"CYP2D6": {"*1": 1, "*17": 1}}	{"Latino": 0.016959814, "American": 0.005443348, "European": 0.002235409, "Oceanian": 0.001285121, "East Asian": 0.0000473795, "Near Eastern": 0.015408477, "Central/South Asian": 0.00028186452, "Sub-Saharan African": 0.060686175, "African American/Afro-Caribbean": 0.07129697}
7989518	7989426	*45/*54	{"CYP2D6": {"*45": 1, "*54": 1}}	{"Latino": null, "American": null, "European": 0.0, "Oceanian": null, "East Asian": 0.0, "Near Eastern": 0.0, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7989519	7989426	*13+*1/*59	{"CYP2D6": {"*59": 1, "*13+*1": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7989520	7989426	*13+*2/*49	{"CYP2D6": {"*49": 1, "*13+*2": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7989521	7989426	*45/*50	{"CYP2D6": {"*45": 1, "*50": 1}}	{"Latino": null, "American": null, "European": 0.0, "Oceanian": null, "East Asian": 0.0, "Near Eastern": 0.0, "Central/South Asian": null, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": null}
7989522	7989426	*45/*49	{"CYP2D6": {"*45": 1, "*49": 1}}	{"Latino": null, "American": 0.0, "European": 0.0, "Oceanian": null, "East Asian": 0.0, "Near Eastern": 0.0, "Central/South Asian": 0.0, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": 0.0}
7989523	7989426	*33/*49	{"CYP2D6": {"*33": 1, "*49": 1}}	{"Latino": null, "American": 0.0, "European": 0.0, "Oceanian": null, "East Asian": 0.000004247159, "Near Eastern": 0.0, "Central/South Asian": 0.0, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": 0.0}
7989524	7989426	*36+*10x2/*53	{"CYP2D6": {"*53": 1, "*36+*10x2": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7989525	7989426	*13+*2/*50	{"CYP2D6": {"*50": 1, "*13+*2": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7989526	7989426	*13+*2/*14	{"CYP2D6": {"*14": 1, "*13+*2": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7989527	7989426	*2/*14	{"CYP2D6": {"*2": 1, "*14": 1}}	{"Latino": 0.0, "American": 0.0, "European": 0.0, "Oceanian": 0.0, "East Asian": 0.0011235516, "Near Eastern": null, "Central/South Asian": 0.0, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": 0.0}
7989528	7989426	*2/*17	{"CYP2D6": {"*2": 1, "*17": 1}}	{"Latino": 0.010553134, "American": 0.00229186, "European": 0.0014538466, "Oceanian": 0.00012729941, "East Asian": 0.000022270155, "Near Eastern": 0.011771717, "Central/South Asian": 0.00026380664, "Sub-Saharan African": 0.06731764, "African American/Afro-Caribbean": 0.052229498}
7989529	7989426	*1/*29	{"CYP2D6": {"*1": 1, "*29": 1}}	{"Latino": 0.011117264, "American": 0.0020838433, "European": 0.0005964751, "Oceanian": 0.0, "East Asian": 0.000049645565, "Near Eastern": 0.0038588236, "Central/South Asian": 0.0009421928, "Sub-Saharan African": 0.033941653, "African American/Afro-Caribbean": 0.036926452}
7989530	7989426	*13+*1/*29	{"CYP2D6": {"*29": 1, "*13+*1": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984115	7984110	*4/*10	{"CYP2B6": {"*4": 1, "*10": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984118	7984110	*3/*4	{"CYP2B6": {"*3": 1, "*4": 1}}	{"Latino": 0.0003918298, "European": 0.00017432802, "Oceanian": 0.0, "East Asian": 0.0, "Near Eastern": null, "Central/South Asian": 0.00048329527, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": 0.000046536086}
7984122	7984110	*4/*45	{"CYP2B6": {"*4": 1, "*45": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984124	7984110	*4/*48	{"CYP2B6": {"*4": 1, "*48": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984127	7984110	*4/*47	{"CYP2B6": {"*4": 1, "*47": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984131	7984130	*5/*45	{"CYP2B6": {"*5": 1, "*45": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984134	7984130	*5/*46	{"CYP2B6": {"*5": 1, "*46": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984137	7984130	*17/*45	{"CYP2B6": {"*17": 1, "*45": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984139	7984130	*17/*47	{"CYP2B6": {"*17": 1, "*47": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984142	7984130	*17/*44	{"CYP2B6": {"*17": 1, "*44": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984145	7984130	*32/*48	{"CYP2B6": {"*32": 1, "*48": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984147	7984130	*32/*49	{"CYP2B6": {"*32": 1, "*49": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984150	7984130	*32/*44	{"CYP2B6": {"*32": 1, "*44": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984153	7984130	*1/*11	{"CYP2B6": {"*1": 1, "*11": 1}}	{"Latino": 0.001672233, "European": 0.0029577888, "Oceanian": null, "East Asian": 0.0, "Near Eastern": null, "Central/South Asian": 0.0026694643, "Sub-Saharan African": 0.044635024, "African American/Afro-Caribbean": 0.0020395957}
7984156	7984130	*23/*31	{"CYP2B6": {"*23": 1, "*31": 1}}	{"Latino": 0.0, "European": 0.00000000082433327, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": 0.0, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984159	7984130	*10/*31	{"CYP2B6": {"*10": 1, "*31": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984162	7984130	*10/*32	{"CYP2B6": {"*10": 1, "*32": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984165	7984130	*2/*10	{"CYP2B6": {"*2": 1, "*10": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984168	7984130	*2/*15	{"CYP2B6": {"*2": 1, "*15": 1}}	{"Latino": 0.0001420494, "European": 0.00068091933, "Oceanian": null, "East Asian": 0.0, "Near Eastern": null, "Central/South Asian": 0.0000076653505, "Sub-Saharan African": 0.00090117624, "African American/Afro-Caribbean": 0.0}
7984171	7984130	*1/*24	{"CYP2B6": {"*1": 1, "*24": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984174	7984130	*24/*32	{"CYP2B6": {"*24": 1, "*32": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984177	7984130	*2/*21	{"CYP2B6": {"*2": 1, "*21": 1}}	{"Latino": 0.0, "European": 0.0, "Oceanian": null, "East Asian": 0.0, "Near Eastern": null, "Central/South Asian": 0.0, "Sub-Saharan African": 0.0007892432, "African American/Afro-Caribbean": 0.0}
7984180	7984130	*1/*33	{"CYP2B6": {"*1": 1, "*33": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984183	7984130	*25/*31	{"CYP2B6": {"*25": 1, "*31": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984188	7984130	*2/*33	{"CYP2B6": {"*2": 1, "*33": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984191	7984130	*1/*44	{"CYP2B6": {"*1": 1, "*44": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984194	7984130	*14/*31	{"CYP2B6": {"*14": 1, "*31": 1}}	{"Latino": 0.0, "European": 0.000000076038354, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": 0.0, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984197	7984130	*1/*48	{"CYP2B6": {"*1": 1, "*48": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984200	7984130	*3/*32	{"CYP2B6": {"*3": 1, "*32": 1}}	{"Latino": 0.000000109842965, "European": 0.0, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": 0.0, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
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7984209	7984130	*2/*48	{"CYP2B6": {"*2": 1, "*48": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984212	7984130	*2/*49	{"CYP2B6": {"*2": 1, "*49": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984215	7984130	*27/*32	{"CYP2B6": {"*27": 1, "*32": 1}}	{"Latino": 0.0, "European": 0.0, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": 0.0, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984218	7984130	*5/*22	{"CYP2B6": {"*5": 1, "*22": 1}}	{"Latino": null, "European": 0.003233395, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": 0.0012399999, "African American/Afro-Caribbean": 0.0013653608}
7984221	7984130	*5/*24	{"CYP2B6": {"*5": 1, "*24": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984224	7984130	*17/*24	{"CYP2B6": {"*17": 1, "*24": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984227	7984130	*17/*22	{"CYP2B6": {"*17": 1, "*22": 1}}	{"Latino": null, "European": 0.0, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": 0.0007812, "African American/Afro-Caribbean": 0.001562}
7984230	7984130	*5/*33	{"CYP2B6": {"*5": 1, "*33": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984232	7984130	*5/*35	{"CYP2B6": {"*5": 1, "*35": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984235	7984130	*32/*35	{"CYP2B6": {"*32": 1, "*35": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984238	7984130	*31/*47	{"CYP2B6": {"*31": 1, "*47": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984241	7984130	*32/*33	{"CYP2B6": {"*32": 1, "*33": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984243	7984130	*10/*17	{"CYP2B6": {"*10": 1, "*17": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984247	7984245	*6/*35	{"CYP2B6": {"*6": 1, "*35": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984250	7984245	*19/*25	{"CYP2B6": {"*19": 1, "*25": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984252	7984245	*29/*47	{"CYP2B6": {"*29": 1, "*47": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984255	7984245	*29/*49	{"CYP2B6": {"*29": 1, "*49": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984258	7984245	*19/*23	{"CYP2B6": {"*19": 1, "*23": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": 0.0, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": 0.0}
7984261	7984245	*29/*45	{"CYP2B6": {"*29": 1, "*45": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984265	7984245	*6/*44	{"CYP2B6": {"*6": 1, "*44": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984267	7984245	*6/*46	{"CYP2B6": {"*6": 1, "*46": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984270	7984245	*6/*45	{"CYP2B6": {"*6": 1, "*45": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984273	7984245	*6/*49	{"CYP2B6": {"*6": 1, "*49": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984276	7984245	*9/*21	{"CYP2B6": {"*9": 1, "*21": 1}}	{"Latino": 0.0, "European": 0.0, "Oceanian": null, "East Asian": 0.0, "Near Eastern": null, "Central/South Asian": 0.0, "Sub-Saharan African": null, "African American/Afro-Caribbean": 0.0}
7984279	7984245	*9/*25	{"CYP2B6": {"*9": 1, "*25": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984282	7984245	*7/*44	{"CYP2B6": {"*7": 1, "*44": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984285	7984245	*7/*46	{"CYP2B6": {"*7": 1, "*46": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984287	7984245	*7/*48	{"CYP2B6": {"*7": 1, "*48": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984290	7984245	*19/*49	{"CYP2B6": {"*19": 1, "*49": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984293	7984245	*19/*46	{"CYP2B6": {"*19": 1, "*46": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984296	7984245	*9/*45	{"CYP2B6": {"*9": 1, "*45": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984298	7984245	*9/*47	{"CYP2B6": {"*9": 1, "*47": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984301	7984245	*9/*48	{"CYP2B6": {"*9": 1, "*48": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984304	7984245	*40/*46	{"CYP2B6": {"*40": 1, "*46": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984307	7984245	*40/*49	{"CYP2B6": {"*40": 1, "*49": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984309	7984245	*41/*45	{"CYP2B6": {"*41": 1, "*45": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984312	7984245	*41/*48	{"CYP2B6": {"*41": 1, "*48": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984315	7984245	*42/*45	{"CYP2B6": {"*42": 1, "*45": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984318	7984245	*20/*25	{"CYP2B6": {"*20": 1, "*25": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984320	7984245	*42/*48	{"CYP2B6": {"*42": 1, "*48": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984323	7984245	*42/*44	{"CYP2B6": {"*42": 1, "*44": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984326	7984245	*3/*6	{"CYP2B6": {"*3": 1, "*6": 1}}	{"Latino": 0.00078059925, "European": 0.0009937272, "Oceanian": 0.0, "East Asian": 0.0, "Near Eastern": null, "Central/South Asian": 0.00090312754, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": 0.001432221}
7984329	7984245	*43/*46	{"CYP2B6": {"*43": 1, "*46": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7989531	7989426	*46/*54	{"CYP2D6": {"*46": 1, "*54": 1}}	{"Latino": null, "American": null, "European": 0.0, "Oceanian": null, "East Asian": 0.0, "Near Eastern": 0.0, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984334	7984245	*43/*49	{"CYP2B6": {"*43": 1, "*49": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984336	7984245	*20/*33	{"CYP2B6": {"*20": 1, "*33": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984339	7984245	*10/*19	{"CYP2B6": {"*10": 1, "*19": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984342	7984245	*33/*41	{"CYP2B6": {"*33": 1, "*41": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984344	7984245	*21/*41	{"CYP2B6": {"*21": 1, "*41": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984347	7984245	*20/*45	{"CYP2B6": {"*20": 1, "*45": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984350	7984245	*33/*37	{"CYP2B6": {"*33": 1, "*37": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984352	7984245	*10/*26	{"CYP2B6": {"*10": 1, "*26": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984355	7984245	*33/*39	{"CYP2B6": {"*33": 1, "*39": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984358	7984245	*33/*34	{"CYP2B6": {"*33": 1, "*34": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984361	7984245	*21/*39	{"CYP2B6": {"*21": 1, "*39": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984363	7984245	*20/*49	{"CYP2B6": {"*20": 1, "*49": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984366	7984245	*22/*40	{"CYP2B6": {"*22": 1, "*40": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984369	7984245	*10/*41	{"CYP2B6": {"*10": 1, "*41": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984371	7984245	*22/*36	{"CYP2B6": {"*22": 1, "*36": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984374	7984245	*11/*26	{"CYP2B6": {"*11": 1, "*26": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984377	7984245	*22/*39	{"CYP2B6": {"*22": 1, "*39": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984379	7984245	*21/*42	{"CYP2B6": {"*21": 1, "*42": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984382	7984245	*22/*34	{"CYP2B6": {"*22": 1, "*34": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984385	7984245	*10/*39	{"CYP2B6": {"*10": 1, "*39": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984387	7984245	*23/*40	{"CYP2B6": {"*23": 1, "*40": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984390	7984245	*23/*41	{"CYP2B6": {"*23": 1, "*41": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984393	7984245	*23/*42	{"CYP2B6": {"*23": 1, "*42": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984395	7984245	*11/*42	{"CYP2B6": {"*11": 1, "*42": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984398	7984245	*11/*36	{"CYP2B6": {"*11": 1, "*36": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7989532	7989426	*34/*54	{"CYP2D6": {"*34": 1, "*54": 1}}	{"Latino": null, "American": null, "European": 0.0, "Oceanian": null, "East Asian": 0.0000078280345, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984403	7984245	*34/*49	{"CYP2B6": {"*34": 1, "*49": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984406	7984245	*11/*39	{"CYP2B6": {"*11": 1, "*39": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984409	7984245	*34/*44	{"CYP2B6": {"*34": 1, "*44": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984411	7984245	*23/*34	{"CYP2B6": {"*23": 1, "*34": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984414	7984245	*35/*36	{"CYP2B6": {"*35": 1, "*36": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984417	7984245	*24/*26	{"CYP2B6": {"*24": 1, "*26": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984419	7984245	*34/*47	{"CYP2B6": {"*34": 1, "*47": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984422	7984245	*24/*42	{"CYP2B6": {"*24": 1, "*42": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984425	7984245	*25/*34	{"CYP2B6": {"*25": 1, "*34": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984427	7984245	*36/*45	{"CYP2B6": {"*36": 1, "*45": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984430	7984245	*25/*29	{"CYP2B6": {"*25": 1, "*29": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984433	7984245	*24/*34	{"CYP2B6": {"*24": 1, "*34": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984435	7984245	*25/*26	{"CYP2B6": {"*25": 1, "*26": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984438	7984245	*3/*26	{"CYP2B6": {"*3": 1, "*26": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984441	7984245	*25/*43	{"CYP2B6": {"*25": 1, "*43": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984444	7984245	*37/*45	{"CYP2B6": {"*37": 1, "*45": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984446	7984245	*26/*35	{"CYP2B6": {"*26": 1, "*35": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984449	7984245	*15/*20	{"CYP2B6": {"*15": 1, "*20": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": 0.0, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": 0.00046512324, "African American/Afro-Caribbean": 0.0}
7984452	7984245	*14/*29	{"CYP2B6": {"*14": 1, "*29": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984455	7984245	*25/*36	{"CYP2B6": {"*25": 1, "*36": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984457	7984245	*14/*26	{"CYP2B6": {"*14": 1, "*26": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984460	7984245	*36/*48	{"CYP2B6": {"*36": 1, "*48": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984463	7984245	*3/*36	{"CYP2B6": {"*3": 1, "*36": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984466	7984245	*14/*43	{"CYP2B6": {"*14": 1, "*43": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984468	7984245	*3/*39	{"CYP2B6": {"*3": 1, "*39": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984471	7984245	*26/*45	{"CYP2B6": {"*26": 1, "*45": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984472	7984245	*27/*36	{"CYP2B6": {"*27": 1, "*36": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984473	7984245	*26/*46	{"CYP2B6": {"*26": 1, "*46": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984474	7984245	*14/*40	{"CYP2B6": {"*14": 1, "*40": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984475	7984245	*14/*41	{"CYP2B6": {"*14": 1, "*41": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984476	7984245	*14/*39	{"CYP2B6": {"*14": 1, "*39": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984477	7984245	*15/*29	{"CYP2B6": {"*15": 1, "*29": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984478	7984245	*37/*47	{"CYP2B6": {"*37": 1, "*47": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984479	7984245	*14/*36	{"CYP2B6": {"*14": 1, "*36": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984480	7984245	*15/*26	{"CYP2B6": {"*15": 1, "*26": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984481	7984245	*37/*48	{"CYP2B6": {"*37": 1, "*48": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984482	7984245	*14/*37	{"CYP2B6": {"*14": 1, "*37": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984483	7984245	*37/*49	{"CYP2B6": {"*37": 1, "*49": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984484	7984245	*27/*29	{"CYP2B6": {"*27": 1, "*29": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984485	7984245	*6/*11	{"CYP2B6": {"*6": 1, "*11": 1}}	{"Latino": 0.0007115446, "European": 0.0014043179, "Oceanian": null, "East Asian": 0.0, "Near Eastern": null, "Central/South Asian": 0.00081160746, "Sub-Saharan African": 0.05317751, "African American/Afro-Caribbean": 0.0015635805}
7984486	7984245	*3/*41	{"CYP2B6": {"*3": 1, "*41": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984487	7984245	*6/*10	{"CYP2B6": {"*6": 1, "*10": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984488	7984245	*3/*40	{"CYP2B6": {"*3": 1, "*40": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984489	7984245	*3/*43	{"CYP2B6": {"*3": 1, "*43": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984490	7984245	*3/*42	{"CYP2B6": {"*3": 1, "*42": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984491	7984245	*6/*15	{"CYP2B6": {"*6": 1, "*15": 1}}	{"Latino": 0.0006832306, "European": 0.0032258877, "Oceanian": null, "East Asian": 0.0, "Near Eastern": null, "Central/South Asian": 0.000034587556, "Sub-Saharan African": 0.010897593, "African American/Afro-Caribbean": 0.0}
7984492	7984245	*6/*14	{"CYP2B6": {"*6": 1, "*14": 1}}	{"Latino": 0.00071184745, "European": 0.0023706146, "Oceanian": null, "East Asian": 0.0, "Near Eastern": null, "Central/South Asian": 0.0010153396, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": 0.0}
7984493	7984245	*15/*43	{"CYP2B6": {"*15": 1, "*43": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984494	7984245	*39/*45	{"CYP2B6": {"*39": 1, "*45": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7989533	7989426	*46/*55	{"CYP2D6": {"*46": 1, "*55": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": 0.0, "Near Eastern": 0.0, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7989534	7989426	*13+*2/*17	{"CYP2D6": {"*17": 1, "*13+*2": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984498	7984245	*27/*40	{"CYP2B6": {"*27": 1, "*40": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984501	7984245	*15/*41	{"CYP2B6": {"*15": 1, "*41": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984504	7984245	*27/*43	{"CYP2B6": {"*27": 1, "*43": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984506	7984245	*15/*36	{"CYP2B6": {"*15": 1, "*36": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984509	7984245	*15/*37	{"CYP2B6": {"*15": 1, "*37": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984512	7984245	*26/*49	{"CYP2B6": {"*26": 1, "*49": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984514	7984245	*7/*10	{"CYP2B6": {"*7": 1, "*10": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984518	7984245	*7/*14	{"CYP2B6": {"*7": 1, "*14": 1}}	{"Latino": 0.000026908925, "European": 0.00025242462, "Oceanian": null, "East Asian": 0.0, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": 0.0}
7984521	7984245	*7/*15	{"CYP2B6": {"*7": 1, "*15": 1}}	{"Latino": 0.000025827163, "European": 0.0003434947, "Oceanian": null, "East Asian": 0.0, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": 0.00046512324, "African American/Afro-Caribbean": 0.0}
7984524	7984245	*29/*35	{"CYP2B6": {"*29": 1, "*35": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984527	7984245	*7/*21	{"CYP2B6": {"*7": 1, "*21": 1}}	{"Latino": 0.0, "European": 0.0, "Oceanian": null, "East Asian": 0.0, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": 0.00040735136, "African American/Afro-Caribbean": 0.0}
7984530	7984245	*7/*22	{"CYP2B6": {"*7": 1, "*22": 1}}	{"Latino": null, "European": 0.00069461536, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": 0.000992, "African American/Afro-Caribbean": 0.0}
7984534	7984531	*18/*35	{"CYP2B6": {"*18": 1, "*35": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984537	7984531	*18/*33	{"CYP2B6": {"*18": 1, "*33": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984539	7984531	*21/*38	{"CYP2B6": {"*21": 1, "*38": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984542	7984531	*11/*12	{"CYP2B6": {"*11": 1, "*12": 1}}	{"Latino": 0.0000018190628, "European": 0.00000039968606, "Oceanian": null, "East Asian": 0.0, "Near Eastern": null, "Central/South Asian": 0.0, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": 0.0}
7984546	7984531	*8/*22	{"CYP2B6": {"*8": 1, "*22": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": 0.0}
7984548	7984531	*8/*24	{"CYP2B6": {"*8": 1, "*24": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984551	7984531	*8/*27	{"CYP2B6": {"*8": 1, "*27": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984554	7984531	*18/*47	{"CYP2B6": {"*18": 1, "*47": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984556	7984531	*18/*48	{"CYP2B6": {"*18": 1, "*48": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984559	7984531	*18/*44	{"CYP2B6": {"*18": 1, "*44": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984562	7984531	*22/*38	{"CYP2B6": {"*22": 1, "*38": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984564	7984531	*10/*38	{"CYP2B6": {"*10": 1, "*38": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984567	7984531	*8/*33	{"CYP2B6": {"*8": 1, "*33": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984571	7984531	*13/*22	{"CYP2B6": {"*13": 1, "*22": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984574	7984531	*24/*28	{"CYP2B6": {"*24": 1, "*28": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984576	7984531	*11/*38	{"CYP2B6": {"*11": 1, "*38": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
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7984582	7984531	*12/*25	{"CYP2B6": {"*12": 1, "*25": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984584	7984531	*8/*46	{"CYP2B6": {"*8": 1, "*46": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984587	7984531	*8/*47	{"CYP2B6": {"*8": 1, "*47": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984590	7984531	*3/*13	{"CYP2B6": {"*3": 1, "*13": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984593	7984531	*25/*30	{"CYP2B6": {"*25": 1, "*30": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984596	7984531	*13/*27	{"CYP2B6": {"*13": 1, "*27": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984598	7984531	*13/*23	{"CYP2B6": {"*13": 1, "*23": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984601	7984531	*13/*25	{"CYP2B6": {"*13": 1, "*25": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
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7984612	7984531	*12/*45	{"CYP2B6": {"*12": 1, "*45": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984615	7984531	*12/*47	{"CYP2B6": {"*12": 1, "*47": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984618	7984531	*38/*44	{"CYP2B6": {"*38": 1, "*44": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984620	7984531	*38/*46	{"CYP2B6": {"*38": 1, "*46": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
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7984626	7984531	*30/*35	{"CYP2B6": {"*30": 1, "*35": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984628	7984531	*13/*46	{"CYP2B6": {"*13": 1, "*46": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
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7984636	7984531	*30/*44	{"CYP2B6": {"*30": 1, "*44": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984641	7984531	*27/*38	{"CYP2B6": {"*27": 1, "*38": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
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7984649	7984531	*18/*25	{"CYP2B6": {"*18": 1, "*25": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
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7984719	7984665	*33/*46	{"CYP2B6": {"*33": 1, "*46": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
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7984780	7984665	*47/*49	{"CYP2B6": {"*47": 1, "*49": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
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7984786	7984665	*3/*27	{"CYP2B6": {"*3": 1, "*27": 1}}	{"Latino": 0.0, "European": 0.0, "Oceanian": null, "East Asian": 0.0, "Near Eastern": null, "Central/South Asian": 0.0, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": null}
7984789	7984665	*14/*33	{"CYP2B6": {"*14": 1, "*33": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
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7984816	7984665	*25/*46	{"CYP2B6": {"*25": 1, "*46": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984819	7984665	*49/*49	{"CYP2B6": {"*49": 2}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984822	7984665	*25/*49	{"CYP2B6": {"*25": 1, "*49": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984825	7984665	*3/*47	{"CYP2B6": {"*3": 1, "*47": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984827	7984665	*3/*49	{"CYP2B6": {"*3": 1, "*49": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984830	7984665	*15/*44	{"CYP2B6": {"*15": 1, "*44": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984833	7984665	*27/*46	{"CYP2B6": {"*27": 1, "*46": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984836	7984665	*14/*46	{"CYP2B6": {"*14": 1, "*46": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984838	7984665	*14/*48	{"CYP2B6": {"*14": 1, "*48": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
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7984847	7984665	*27/*48	{"CYP2B6": {"*27": 1, "*48": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984849	7984665	*15/*48	{"CYP2B6": {"*15": 1, "*48": 1}}	{"Latino": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
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7989556	7989426	*17x2/*41x2	{"CYP2D6": {"*17x2": 1, "*41x2": 1}}	{"Latino": 0.0000014507777, "American": 0.0, "European": 0.0, "Oceanian": null, "East Asian": 0.0, "Near Eastern": 0.0, "Central/South Asian": 0.0, "Sub-Saharan African": 0.0000016881703, "African American/Afro-Caribbean": 0.0000023776365}
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7984894	7984869	*28/*38	{"CYP2C19": {"*28": 1, "*38": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
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7984909	7984899	*16/*28	{"CYP2C19": {"*16": 1, "*28": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": 0.0, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984911	7984899	*26/*28	{"CYP2C19": {"*26": 1, "*28": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": 0.0, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
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7984924	7984899	*18/*26	{"CYP2C19": {"*18": 1, "*26": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": 0.0, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984927	7984899	*11/*25	{"CYP2C19": {"*11": 1, "*25": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": 0.0, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984930	7984899	*10/*15	{"CYP2C19": {"*10": 1, "*15": 1}}	{"Latino": 0.000009918797, "American": null, "European": 0.0, "Oceanian": null, "East Asian": 0.0000002846039, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": 0.00009148276}
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7984940	7984899	*13/*26	{"CYP2C19": {"*13": 1, "*26": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": 0.0, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984945	7984942	*17/*19	{"CYP2C19": {"*17": 1, "*19": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": 0.00000808236, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984947	7984942	*17/*26	{"CYP2C19": {"*17": 1, "*26": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": 0.0, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984951	7984949	*9/*26	{"CYP2C19": {"*9": 1, "*26": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": 0.0, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984955	7984949	*19/*26	{"CYP2C19": {"*19": 1, "*26": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": 0.0, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984957	7984949	*16/*19	{"CYP2C19": {"*16": 1, "*19": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": 0.0, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984961	7984949	*16/*26	{"CYP2C19": {"*16": 1, "*26": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": 0.0, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984963	7984949	*16/*16	{"CYP2C19": {"*16": 2}}	{"Latino": 0.0, "American": null, "European": 0.0, "Oceanian": null, "East Asian": 0.0, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": 0.0}
7984967	7984949	*25/*26	{"CYP2C19": {"*25": 1, "*26": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": 0.0, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984970	7984949	*9/*25	{"CYP2C19": {"*9": 1, "*25": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": 0.000000043057007, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984976	7984972	*4/*15	{"CYP2C19": {"*4": 1, "*15": 1}}	{"Latino": 0.000004162331, "American": null, "European": 0.000009438988, "Oceanian": null, "East Asian": 0.0000004820327, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": 0.0}
7984979	7984972	*6/*38	{"CYP2C19": {"*6": 1, "*38": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984982	7984972	*18/*36	{"CYP2C19": {"*18": 1, "*36": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984985	7984972	*2/*38	{"CYP2C19": {"*2": 1, "*38": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7984988	7984972	*22/*28	{"CYP2C19": {"*22": 1, "*28": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": 0.0, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
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7984996	7984972	*7/*38	{"CYP2C19": {"*7": 1, "*38": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7985000	7984972	*1/*5	{"CYP2C19": {"*1": 1, "*5": 1}}	{"Latino": 0.0, "American": 0.0, "European": 0.00003596772, "Oceanian": null, "East Asian": 0.0038415769, "Near Eastern": 0.0, "Central/South Asian": 0.0, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": 0.0}
7985003	7984972	*5/*18	{"CYP2C19": {"*5": 1, "*18": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": 0.00012815688, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7985007	7984972	*1/*8	{"CYP2C19": {"*1": 1, "*8": 1}}	{"Latino": 0.0018256119, "American": 0.0, "European": 0.0042001726, "Oceanian": null, "East Asian": 0.0, "Near Eastern": 0.0, "Central/South Asian": 0.0, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": 0.0012250749}
7985010	7984972	*11/*22	{"CYP2C19": {"*11": 1, "*22": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": 0.0, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7985013	7984972	*6/*13	{"CYP2C19": {"*6": 1, "*13": 1}}	{"Latino": 0.0, "American": null, "European": 0.0000013429261, "Oceanian": null, "East Asian": 0.00000012886431, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": 0.0}
7985018	7984972	*1/*22	{"CYP2C19": {"*1": 1, "*22": 1}}	{"Latino": 0.0, "American": null, "European": 0.0, "Oceanian": null, "East Asian": 0.0, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": 0.0}
7985021	7984972	*6/*18	{"CYP2C19": {"*6": 1, "*18": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": 0.000022253706, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7985025	7984972	*28/*36	{"CYP2C19": {"*28": 1, "*36": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
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7985251	7985225	*30/*39	{"CYP2C19": {"*30": 1, "*39": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7985253	7985225	*12/*31	{"CYP2C19": {"*12": 1, "*31": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": 0.000000042307125, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7985256	7985225	*23/*39	{"CYP2C19": {"*23": 1, "*39": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7985259	7985225	*12/*23	{"CYP2C19": {"*12": 1, "*23": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": 0.00000012333602, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7985262	7985225	*39/*39	{"CYP2C19": {"*39": 2}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7985265	7985225	*31/*39	{"CYP2C19": {"*31": 1, "*39": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7985268	7985225	*29/*31	{"CYP2C19": {"*29": 1, "*31": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": 0.00000006814625, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7985271	7985225	*29/*34	{"CYP2C19": {"*29": 1, "*34": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": 0.0, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7985274	7985225	*12/*34	{"CYP2C19": {"*12": 1, "*34": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": 0.0, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7985277	7985225	*32/*32	{"CYP2C19": {"*32": 2}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": 0.00000003072033, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7985280	7985225	*32/*39	{"CYP2C19": {"*32": 1, "*39": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7985284	7985281	*17/*39	{"CYP2C19": {"*17": 1, "*39": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7985287	7985281	*17/*34	{"CYP2C19": {"*17": 1, "*34": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": 0.0, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7985290	7985281	*17/*32	{"CYP2C19": {"*17": 1, "*32": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": 0.0000072006474, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7985294	7985292	*15/*23	{"CYP2C19": {"*15": 1, "*23": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": 0.000001540351, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7985297	7985292	*18/*33	{"CYP2C19": {"*18": 1, "*33": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": 0.000006964547, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7985300	7985292	*14/*28	{"CYP2C19": {"*14": 1, "*28": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": 0.0, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": null}
7985303	7985292	*13/*34	{"CYP2C19": {"*13": 1, "*34": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": 0.0, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7985305	7985292	*11/*12	{"CYP2C19": {"*11": 1, "*12": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": 0.0, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7985309	7985292	*15/*33	{"CYP2C19": {"*15": 1, "*33": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": 0.000000476384, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7985311	7985292	*15/*34	{"CYP2C19": {"*15": 1, "*34": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": 0.0, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7985314	7985292	*15/*31	{"CYP2C19": {"*15": 1, "*31": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": 0.00000052837623, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7985317	7985292	*34/*38	{"CYP2C19": {"*34": 1, "*38": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7989557	7989426	*36+*10x2/*39	{"CYP2D6": {"*39": 1, "*36+*10x2": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7985322	7985292	*11/*23	{"CYP2C19": {"*11": 1, "*23": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": 0.0, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7985324	7985292	*14/*38	{"CYP2C19": {"*14": 1, "*38": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7985327	7985292	*1/*23	{"CYP2C19": {"*1": 1, "*23": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": 0.0006750299, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7985330	7985292	*28/*30	{"CYP2C19": {"*28": 1, "*30": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": 0.0, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7985333	7985292	*28/*33	{"CYP2C19": {"*28": 1, "*33": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": 0.0, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7985336	7985292	*11/*39	{"CYP2C19": {"*11": 1, "*39": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7985339	7985292	*13/*14	{"CYP2C19": {"*13": 1, "*14": 1}}	{"Latino": 0.0, "American": null, "European": 0.0, "Oceanian": null, "East Asian": 0.000000026350968, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": 0.0}
7985342	7985292	*15/*39	{"CYP2C19": {"*15": 1, "*39": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7985345	7985292	*1/*32	{"CYP2C19": {"*1": 1, "*32": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": 0.00020876633, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7985348	7985292	*1/*33	{"CYP2C19": {"*1": 1, "*33": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": 0.00020876633, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7985351	7985292	*13/*32	{"CYP2C19": {"*13": 1, "*32": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": 0.000000040329535, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7985354	7985292	*1/*39	{"CYP2C19": {"*1": 1, "*39": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7985357	7985292	*14/*18	{"CYP2C19": {"*14": 1, "*18": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": 0.0000045505744, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7985360	7985292	*13/*23	{"CYP2C19": {"*13": 1, "*23": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": 0.00000013040246, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7985364	7985363	*26/*32	{"CYP2C19": {"*26": 1, "*32": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": 0.0, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7985367	7985363	*10/*30	{"CYP2C19": {"*10": 1, "*30": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": 0.0000000407123, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7985369	7985363	*26/*30	{"CYP2C19": {"*26": 1, "*30": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": 0.0, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7985372	7985363	*25/*39	{"CYP2C19": {"*25": 1, "*39": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7985375	7985363	*10/*23	{"CYP2C19": {"*10": 1, "*23": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": 0.00000011868671, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7985379	7985363	*19/*30	{"CYP2C19": {"*19": 1, "*30": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": 0.00000007649069, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7985381	7985363	*16/*23	{"CYP2C19": {"*16": 1, "*23": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": 0.0, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7985384	7985363	*19/*33	{"CYP2C19": {"*19": 1, "*33": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": 0.000000068964006, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7985387	7985363	*12/*16	{"CYP2C19": {"*12": 1, "*16": 1}}	{"Latino": 0.0, "American": null, "European": 0.0, "Oceanian": null, "East Asian": 0.0, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": 0.0}
7985393	7985363	*10/*34	{"CYP2C19": {"*10": 1, "*34": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": 0.0, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7985396	7985363	*9/*23	{"CYP2C19": {"*9": 1, "*23": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": 0.00000013040246, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7985399	7985363	*16/*33	{"CYP2C19": {"*16": 1, "*33": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": 0.0, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7985402	7985363	*16/*31	{"CYP2C19": {"*16": 1, "*31": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": 0.0, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7985405	7985363	*12/*25	{"CYP2C19": {"*12": 1, "*25": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": 0.000000040723776, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7985408	7985363	*9/*32	{"CYP2C19": {"*9": 1, "*32": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": 0.000000040329535, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7985411	7985363	*9/*33	{"CYP2C19": {"*9": 1, "*33": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": 0.000000040329535, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7985414	7985363	*25/*32	{"CYP2C19": {"*25": 1, "*32": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": 0.00000006559587, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7985417	7985363	*25/*30	{"CYP2C19": {"*25": 1, "*30": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": 0.00000007275496, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7985420	7985363	*14/*19	{"CYP2C19": {"*14": 1, "*19": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": 0.00000004506048, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7985423	7985363	*14/*16	{"CYP2C19": {"*14": 1, "*16": 1}}	{"Latino": 0.0, "American": null, "European": 0.0, "Oceanian": null, "East Asian": 0.0, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": 0.0}
7985427	7985424	*7/*29	{"CYP2C19": {"*7": 1, "*29": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": 0.0000000398799, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7985430	7985424	*22/*31	{"CYP2C19": {"*22": 1, "*31": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": 0.0, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7985433	7985424	*22/*23	{"CYP2C19": {"*22": 1, "*23": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": 0.0, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7985436	7985424	*22/*29	{"CYP2C19": {"*22": 1, "*29": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": 0.0, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7985439	7985424	*7/*34	{"CYP2C19": {"*7": 1, "*34": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": 0.0, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7985442	7985424	*8/*29	{"CYP2C19": {"*8": 1, "*29": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": 0.0, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7985445	7985424	*22/*39	{"CYP2C19": {"*22": 1, "*39": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7985448	7985424	*23/*24	{"CYP2C19": {"*23": 1, "*24": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": 0.00000021209921, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7985451	7985424	*34/*36	{"CYP2C19": {"*34": 1, "*36": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7985454	7985424	*8/*33	{"CYP2C19": {"*8": 1, "*33": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": 0.0, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7985457	7985424	*8/*39	{"CYP2C19": {"*8": 1, "*39": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7985460	7985424	*24/*30	{"CYP2C19": {"*24": 1, "*30": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": 0.00000007275496, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7989558	7989426	*14/*29x2	{"CYP2D6": {"*14": 1, "*29x2": 1}}	{"Latino": 0.0, "American": 0.0, "European": 0.0, "Oceanian": null, "East Asian": 0.0, "Near Eastern": null, "Central/South Asian": 0.0, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": 0.0}
7985466	7985424	*24/*29	{"CYP2C19": {"*24": 1, "*29": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": 0.00000006559587, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7985469	7985424	*23/*35	{"CYP2C19": {"*23": 1, "*35": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": 0.0, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7985472	7985424	*3/*14	{"CYP2C19": {"*3": 1, "*14": 1}}	{"Latino": 0.0, "American": 0.0, "European": 0.0, "Oceanian": null, "East Asian": 0.000016599484, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": 0.0}
7985475	7985424	*2/*29	{"CYP2C19": {"*2": 1, "*29": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": 0.000099387245, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7985478	7985424	*24/*39	{"CYP2C19": {"*24": 1, "*39": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7985481	7985424	*12/*36	{"CYP2C19": {"*12": 1, "*36": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7985484	7985424	*3/*23	{"CYP2C19": {"*3": 1, "*23": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": 0.0000821455, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7985487	7985424	*2/*32	{"CYP2C19": {"*2": 1, "*32": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": 0.000099387245, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7985490	7985424	*3/*29	{"CYP2C19": {"*3": 1, "*29": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": 0.00002540512, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7985493	7985424	*37/*39	{"CYP2C19": {"*37": 1, "*39": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7985496	7985424	*3/*32	{"CYP2C19": {"*3": 1, "*32": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": 0.00002540512, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7985499	7985424	*3/*34	{"CYP2C19": {"*3": 1, "*34": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": 0.0, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7985502	7985424	*4/*29	{"CYP2C19": {"*4": 1, "*29": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": 0.000000062169185, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7985505	7985424	*30/*36	{"CYP2C19": {"*30": 1, "*36": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7985508	7985424	*14/*37	{"CYP2C19": {"*14": 1, "*37": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7985511	7985424	*4/*30	{"CYP2C19": {"*4": 1, "*30": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": 0.00000006895429, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7985515	7985424	*4/*32	{"CYP2C19": {"*4": 1, "*32": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": 0.000000062169185, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7985517	7985424	*4/*34	{"CYP2C19": {"*4": 1, "*34": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": 0.0, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7985520	7985424	*31/*35	{"CYP2C19": {"*31": 1, "*35": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": 0.0, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
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7985571	7985551	*9/*14	{"CYP2C9": {"*9": 1, "*14": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": 0.0, "Near Eastern": 0.0, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
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7985581	7985551	*1/*5	{"CYP2C9": {"*1": 1, "*5": 1}}	{"Latino": 0.015036881, "American": 0.0027197485, "European": 0.00027664241, "Oceanian": null, "East Asian": 0.0, "Near Eastern": 0.0008172695, "Central/South Asian": 0.0, "Sub-Saharan African": 0.014983015, "African American/Afro-Caribbean": 0.020254381}
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7985626	7985622	*28/*50	{"CYP2C9": {"*28": 1, "*50": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7985630	7985622	*16/*55	{"CYP2C9": {"*16": 1, "*55": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": 0.000039054517, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
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7985683	7985622	*55/*61	{"CYP2C9": {"*55": 1, "*61": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
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7985689	7985622	*55/*55	{"CYP2C9": {"*55": 2}}	{"Latino": 0.0, "American": null, "European": 0.0, "Oceanian": null, "East Asian": 0.00010816, "Near Eastern": 0.0, "Central/South Asian": 0.0, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7985693	7985622	*5/*5	{"CYP2C9": {"*5": 2}}	{"Latino": 0.00007603613, "American": 0.0000022240092, "European": 0.000000030444234, "Oceanian": null, "East Asian": 0.0, "Near Eastern": 0.00000027318043, "Central/South Asian": 0.0, "Sub-Saharan African": 0.000106623, "African American/Afro-Caribbean": 0.0001351851}
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7985848	7985622	*28/*38	{"CYP2C9": {"*28": 1, "*38": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
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7985902	7985855	*3/*5	{"CYP2C9": {"*3": 1, "*5": 1}}	{"Latino": 0.0007003223, "American": 0.00008964127, "European": 0.000026362544, "Oceanian": null, "East Asian": 0.0, "Near Eastern": 0.00008625532, "Central/South Asian": 0.0, "Sub-Saharan African": 0.00023037891, "African American/Afro-Caribbean": 0.0003140643}
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7985928	7985855	*33/*44	{"CYP2C9": {"*33": 1, "*44": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": 0.0, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
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7987432	7987122	*15/*34	{"CYP2C9": {"*15": 1, "*34": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7987434	7987122	*24/*65	{"CYP2C9": {"*24": 1, "*65": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
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