--
--

\restrict W4MDyxXge2cmt2KjTdm6PCggicmUwiig7hX2Sv1FDgYUdXfbmGWxPKpv2OQ7aac


SELECT pg_catalog.set_config('search_path', '', false);

--
-- Name: cpic; Type: SCHEMA; Schema: -; Owner: -
--

CREATE SCHEMA cpic;


--
-- Name: increment_version(); Type: FUNCTION; Schema: cpic; Owner: -
--

CREATE FUNCTION cpic.increment_version() RETURNS trigger
    LANGUAGE plpgsql
    AS $$
BEGIN
  new.version := new.version + 1;
  return new;
END;
$$;


--
-- Name: pharmgkb_guideline_alleles(text); Type: FUNCTION; Schema: cpic; Owner: -
--

CREATE FUNCTION cpic.pharmgkb_guideline_alleles(pharmgkbdrugid text) RETURNS TABLE(genesymbol text, chr text, lookupmethod text, alleles text[])
    LANGUAGE sql STABLE
    AS $$
select
    a.genesymbol,
    g.chr,
    g.lookupmethod,
    array_agg(distinct a.name order by a.name) as alleles
from allele a join gene g on a.genesymbol=g.symbol
where
    a.clinicalfunctionalstatus is not null
    and g.lookupmethod!='ALLELE_STATUS'
    and a.genesymbol in (
        select distinct jsonb_object_keys(p.lookupkey) as genes
        from recommendation p join guideline g on p.guidelineid = g.id join drug d on p.drugid=d.drugid
        where d.pharmgkbid=pharmgkbdrugid
    )
group by a.genesymbol, g.chr, g.lookupmethod
union all
select
    g.symbol as genesymbol,
    g.chr,
    g.lookupmethod,
    array_agg(distinct a.value order by a.value) as alleles
from
    recommendation r
    join drug d on r.drugid = d.drugid,
    jsonb_each_text(r.lookupkey) a
    join gene g on (a.key=g.symbol)
where
    r.allelestatus is not null
    and g.lookupmethod='ALLELE_STATUS'
    and d.pharmgkbid=pharmgkbdrugid
    and upper(a.value) != 'NO RESULT'
group by g.symbol, g.chr, g.lookupmethod
$$;


--
-- Name: FUNCTION pharmgkb_guideline_alleles(pharmgkbdrugid text); Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON FUNCTION cpic.pharmgkb_guideline_alleles(pharmgkbdrugid text) IS 'For a given PharmGKB drug ID, list the alleles that are options for looking up recommendations';


--
-- Name: pharmgkb_guideline_recommendation(text, text); Type: FUNCTION; Schema: cpic; Owner: -
--

CREATE FUNCTION cpic.pharmgkb_guideline_recommendation(drugidarg text, lookupkeyarg text) RETURNS TABLE(drugname text, recommendationid integer, implications jsonb, drugrecommendation text, classification text, phenotypes jsonb, activityscore jsonb, allelestatus jsonb, population text, comments text)
    LANGUAGE sql STABLE
    AS $$
select
    d.name as drugname,
    r.id as recommendationid,
    r.implications,
    r.drugrecommendation,
    r.classification,
    r.phenotypes,
    r.activityscore,
    r.allelestatus,
    r.population,
    r.comments
from recommendation r join drug d on r.drugid = d.drugid join guideline g on r.guidelineid = g.id
where lookupkey <@ (
    select jsonb_object_agg(a.key, coalesce(d.lookupkey -> a.key, a.value)) as lookup
    from
        json_each(lookupkeyArg::json) a
            left join diplotype d on (d.diplotypekey=jsonb_build_object(a.key, a.value))
)
  and d.pharmgkbid=drugidArg
$$;


--
-- Name: FUNCTION pharmgkb_guideline_recommendation(drugidarg text, lookupkeyarg text); Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON FUNCTION cpic.pharmgkb_guideline_recommendation(drugidarg text, lookupkeyarg text) IS 'For a given PharmGKB guideline and genotype lookup JSON key, give the matching recommendations';


--
-- Name: pharmgkb_recommendation(text); Type: FUNCTION; Schema: cpic; Owner: -
--

CREATE FUNCTION cpic.pharmgkb_recommendation(lookupkeyarg text) RETURNS TABLE(drugname text, drugid text, recommendationid integer, implications jsonb, drugrecommendation text, classification text, phenotypes jsonb, activityscore jsonb, allelestatus jsonb, population text, comments text, guidelineurl text)
    LANGUAGE sql STABLE
    AS $$
select
    d.name as drugname,
    d.pharmgkbid as drugid,
    r.id as recommendationid,
    r.implications,
    r.drugrecommendation,
    r.classification,
    r.phenotypes,
    r.activityscore,
    r.allelestatus,
    r.population,
    r.comments,
    g.url as guidelineurl
from recommendation r join drug d on r.drugid = d.drugid join guideline g on r.guidelineid = g.id
where lookupkey <@ (
    select jsonb_object_agg(a.key, coalesce(d.lookupkey -> a.key, a.value)) as lookup
    from
        json_each(lookupKeyArg::json) a
            left join diplotype d on (d.diplotypekey=jsonb_build_object(a.key, a.value))
)
$$;


--
-- Name: FUNCTION pharmgkb_recommendation(lookupkeyarg text); Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON FUNCTION cpic.pharmgkb_recommendation(lookupkeyarg text) IS 'For a given genotype lookup JSON key, give the matching recommendations for all available drugs';


--
-- Name: cpic_id; Type: SEQUENCE; Schema: cpic; Owner: -
--

CREATE SEQUENCE cpic.cpic_id
    START WITH 110000
    INCREMENT BY 1
    NO MINVALUE
    NO MAXVALUE
    CACHE 1;




--
-- Name: drug; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.drug (
    drugid character varying(20) NOT NULL,
    name text NOT NULL,
    clinpgxid character varying(20),
    rxnormid character varying(20),
    drugbankid character varying(20),
    atcid text[],
    umlscui character varying(20),
    flowchart text,
    version integer DEFAULT 1,
    guidelineid integer
);


--
-- Name: TABLE drug; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.drug IS 'A clinically-used drug.';


--
-- Name: COLUMN drug.drugid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.drug.drugid IS 'A unique identifier for this drug in the form "source:id" where source is some outside knowledge resource and id is their identifier, primary key';


--
-- Name: COLUMN drug.name; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.drug.name IS 'The generic name for this drug, lower-cased, required';


--
-- Name: COLUMN drug.clinpgxid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.drug.clinpgxid IS 'The ClinPGx ID for this drug, optional';


--
-- Name: COLUMN drug.rxnormid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.drug.rxnormid IS 'The RxNorm ID for this drug, optional';


--
-- Name: COLUMN drug.drugbankid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.drug.drugbankid IS 'The DrugBank ID for this drug, optional';


--
-- Name: COLUMN drug.atcid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.drug.atcid IS 'One or more ATC IDs for this drug in an array, optional';


--
-- Name: COLUMN drug.umlscui; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.drug.umlscui IS 'The UMLS Concept Unique ID for this drug, optional';


--
-- Name: COLUMN drug.flowchart; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.drug.flowchart IS 'URL for the flow chart image of this drug';


--
-- Name: COLUMN drug.guidelineid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.drug.guidelineid IS 'The guideline this drug is part of a guideline, null means not a part of any guideline';


--
-- Name: guideline; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.guideline (
    id integer DEFAULT nextval('cpic.cpic_id'::regclass) NOT NULL,
    version integer DEFAULT 1,
    name text NOT NULL,
    url text,
    genes text[],
    notesonusage text,
    clinpgxid text
);


--
-- Name: TABLE guideline; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.guideline IS 'A guideline for a drug or group of drugs';


--
-- Name: COLUMN guideline.id; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.guideline.id IS 'A synthetic numerical ID, primary key';


--
-- Name: COLUMN guideline.version; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.guideline.version IS 'The version number, iterates on modification';


--
-- Name: COLUMN guideline.name; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.guideline.name IS 'The name (title) of this guideline, required';


--
-- Name: COLUMN guideline.url; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.guideline.url IS 'The URL of this guideline on the cpicpgx.org domain, optional';


--
-- Name: COLUMN guideline.genes; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.guideline.genes IS 'The subject genes of this guideline';


--
-- Name: COLUMN guideline.notesonusage; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.guideline.notesonusage IS 'Notes about using a particular guideline within this system. This may include. You may find information here when data for a guideline seems missing or incomplete.';


--
-- Name: COLUMN guideline.clinpgxid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.guideline.clinpgxid IS 'The accession ID in ClinPGx for the guideline';


--
-- Name: recommendation; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.recommendation (
    id integer DEFAULT nextval('cpic.cpic_id'::regclass) NOT NULL,
    guidelineid integer,
    drugid character varying(20),
    implications jsonb,
    drugrecommendation text,
    classification character varying(20),
    phenotypes jsonb,
    activityscore jsonb,
    allelestatus jsonb,
    lookupkey jsonb,
    population text,
    comments text,
    version integer DEFAULT 1,
    dosinginformation boolean DEFAULT false,
    alternatedrugavailable boolean DEFAULT false,
    otherprescribingguidance boolean DEFAULT false
);


--
-- Name: TABLE recommendation; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.recommendation IS 'Recommendations for a gene result pulled from a guideline';


--
-- Name: COLUMN recommendation.id; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.recommendation.id IS 'A synthetic numerical ID, auto-assigned, primary key';


--
-- Name: COLUMN recommendation.guidelineid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.recommendation.guidelineid IS 'The guideline this recommendation appears in';


--
-- Name: COLUMN recommendation.drugid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.recommendation.drugid IS 'The drug this recommendation is for';


--
-- Name: COLUMN recommendation.implications; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.recommendation.implications IS 'Implications for phenotypic measures, this is a JSON mapping of gene to implication';


--
-- Name: COLUMN recommendation.drugrecommendation; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.recommendation.drugrecommendation IS 'Dosing or therapeutic recommendations, depending on particular drug';


--
-- Name: COLUMN recommendation.classification; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.recommendation.classification IS 'Classification of recommendations, described in supplementary meterial';


--
-- Name: COLUMN recommendation.phenotypes; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.recommendation.phenotypes IS 'Phenotypes that this recommendation applies to, this is a JSON mapping of gene to phenotype';


--
-- Name: COLUMN recommendation.activityscore; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.recommendation.activityscore IS 'Activity score that this recommendation applies to, this is a JSON mapping of gene to score value';


--
-- Name: COLUMN recommendation.allelestatus; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.recommendation.allelestatus IS 'Whether or not an allele is present, used mainly for HLA genes, and used for recommendation lookups. This is a JSON mapping of gene to allele status (positive/negative)';


--
-- Name: COLUMN recommendation.lookupkey; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.recommendation.lookupkey IS 'A key to use for finding a specific recommendation. Made of a JSON object of gene symbol to key value. The key value can be one of phenotype, activity score, or allele status depending on the gene.';


--
-- Name: COLUMN recommendation.population; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.recommendation.population IS 'The population this recommendation is applicable to';


--
-- Name: COLUMN recommendation.comments; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.recommendation.comments IS 'Optional comments about the recommendation';


--
-- Name: COLUMN recommendation.dosinginformation; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.recommendation.dosinginformation IS 'The guideline recommends a dose adjustment based on genetic variants or phenotypes (e.g. "poor metabolizers") as a primary course of action. However, the guideline may also describe extenuating circumstances where this action is not appropriate.';


--
-- Name: COLUMN recommendation.alternatedrugavailable; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.recommendation.alternatedrugavailable IS 'The guideline recommends that an alternate drug be selected for patients based on genetic variants or phenotypes (e.g. "poor metabolizers") as a primary course of action. However, the guideline may also describe extenuating circumstances where this action is not appropriate.';


--
-- Name: COLUMN recommendation.otherprescribingguidance; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.recommendation.otherprescribingguidance IS 'The guideline and other prescribing guidance not described as either dose adjustment or alternate drug.';


--
-- Name: recommendation_view; Type: VIEW; Schema: cpic; Owner: -
--

CREATE VIEW cpic.recommendation_view AS
 SELECT r.id AS recommendationid,
    r.lookupkey,
    d.name AS drugname,
    g.name AS guidelinename,
    g.url AS guidelineurl,
    r.implications,
    r.drugrecommendation,
    r.classification,
    r.phenotypes,
    r.activityscore,
    r.population,
    r.comments
   FROM ((cpic.recommendation r
     JOIN cpic.drug d ON (((r.drugid)::text = (d.drugid)::text)))
     JOIN cpic.guideline g ON ((r.guidelineid = g.id)));


--
-- Name: VIEW recommendation_view; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON VIEW cpic.recommendation_view IS 'A view to help find recommendation data when querying by the lookupKey';


--
-- Name: recommendation_lookup(text); Type: FUNCTION; Schema: cpic; Owner: -
--

CREATE FUNCTION cpic.recommendation_lookup(diplotypelookup text) RETURNS SETOF cpic.recommendation_view
    LANGUAGE sql STABLE SECURITY DEFINER
    AS $$
select * from cpic.recommendation_view where lookupkey <@ (
    select jsonb_object_agg(key, value) as lookupkey
    from (select lookupkey from cpic.diplotype where diplotypekey <@ diplotypelookup::jsonb) x,
        json_each(x.lookupkey)
)
$$;


--
-- Name: FUNCTION recommendation_lookup(diplotypelookup text); Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON FUNCTION cpic.recommendation_lookup(diplotypelookup text) IS 'This function helps translate diplotypes into recommendation data. This relies on the recommendation_view to gather and filter relevant information. The diplotypelookup parameter is a JSON object of gene symbol to JSON allele representation.';


--
-- Name: test_alert; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.test_alert (
    id integer DEFAULT nextval('cpic.cpic_id'::regclass) NOT NULL,
    population text,
    cdscontext text NOT NULL,
    genes text[],
    phenotype jsonb,
    activityscore jsonb,
    allelestatus jsonb,
    lookupkey jsonb,
    drugid character varying(20),
    alerttext text[] NOT NULL,
    version integer DEFAULT 1
);


--
-- Name: TABLE test_alert; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.test_alert IS 'Example CDS test alert language';


--
-- Name: COLUMN test_alert.id; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.test_alert.id IS 'A synthetic numerical ID, primary key';


--
-- Name: COLUMN test_alert.population; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.test_alert.population IS 'The population this test alert is applicable to: general, adult, pediatrics, unspecified';


--
-- Name: COLUMN test_alert.cdscontext; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.test_alert.cdscontext IS 'This should be either "Pre-test", "Post-test" or "No CDS". This field is non-null';


--
-- Name: COLUMN test_alert.genes; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.test_alert.genes IS 'One or more genes this test alert uses for trigger conditions';


--
-- Name: COLUMN test_alert.phenotype; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.test_alert.phenotype IS 'A JSON object of gene symbol keys to phenotype description';


--
-- Name: COLUMN test_alert.activityscore; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.test_alert.activityscore IS 'A JSON object of gene symbol keys to gene activity score';


--
-- Name: COLUMN test_alert.allelestatus; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.test_alert.allelestatus IS 'Whether or not an allele is present, used mainly for HLA genes. This is a JSON mapping of gene to allele status (positive/negative)';


--
-- Name: COLUMN test_alert.lookupkey; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.test_alert.lookupkey IS 'A key to use for finding a specific test alert. Made of a JSON object of gene symbol to key value. The key value can be one of phenotype, activity score, or allele status depending on the gene.';


--
-- Name: COLUMN test_alert.drugid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.test_alert.drugid IS 'The ID of a drug this alert text is for';


--
-- Name: COLUMN test_alert.alerttext; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.test_alert.alerttext IS 'An array of one or more pieces of alert text';


--
-- Name: test_alert_view; Type: VIEW; Schema: cpic; Owner: -
--

CREATE VIEW cpic.test_alert_view AS
 SELECT t.id AS testalertid,
    t.lookupkey,
    d.name AS drugname,
    t.population,
    t.alerttext,
    t.cdscontext
   FROM (cpic.test_alert t
     JOIN cpic.drug d ON (((t.drugid)::text = (d.drugid)::text)));


--
-- Name: VIEW test_alert_view; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON VIEW cpic.test_alert_view IS 'A view to help find test alert data when querying by the lookupKey';


--
-- Name: test_alert_lookup(text); Type: FUNCTION; Schema: cpic; Owner: -
--

CREATE FUNCTION cpic.test_alert_lookup(lookup text) RETURNS SETOF cpic.test_alert_view
    LANGUAGE sql STABLE SECURITY DEFINER
    AS $$
select * from cpic.test_alert_view where lookupkey <@ (
    select jsonb_object_agg(key, value) as lookupkey
    from (select lookupkey from cpic.diplotype where diplotypekey <@ lookup::jsonb) x,
        json_each(x.lookupkey)
)
$$;


--
-- Name: FUNCTION test_alert_lookup(lookup text); Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON FUNCTION cpic.test_alert_lookup(lookup text) IS 'This function helps translate diplotypes into test alert data. This relies on the test_alert_view to gather and filter relevant information. The lookup parameter is a JSON object of gene symbol to JSON allele representation.';


--
-- Name: allele; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.allele (
    id integer DEFAULT nextval('cpic.cpic_id'::regclass) NOT NULL,
    version integer DEFAULT 1,
    genesymbol character varying(50) NOT NULL,
    name text NOT NULL,
    functionalstatus text,
    clinicalfunctionalstatus text,
    clinicalfunctionalsubstrate text,
    activityvalue character varying(50),
    definitionid integer NOT NULL,
    citations text[],
    strength text,
    functioncomments text,
    findings text,
    frequency jsonb,
    inferredfrequency boolean DEFAULT false
);


--
-- Name: TABLE allele; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.allele IS 'An allele of a gene';


--
-- Name: COLUMN allele.id; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele.id IS 'A synthetic numerical ID, auto-assigned, primary key';


--
-- Name: COLUMN allele.version; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele.version IS 'The version number, iterates on modification';


--
-- Name: COLUMN allele.genesymbol; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele.genesymbol IS 'The HGNC symbol of the gene the allele is for, required';


--
-- Name: COLUMN allele.name; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele.name IS 'The name of this allele, required';


--
-- Name: COLUMN allele.functionalstatus; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele.functionalstatus IS 'The functional phenotype of this allele';


--
-- Name: COLUMN allele.clinicalfunctionalstatus; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele.clinicalfunctionalstatus IS 'The functional phenotype of this allele used for clinical systems';


--
-- Name: COLUMN allele.clinicalfunctionalsubstrate; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele.clinicalfunctionalsubstrate IS 'Allele clinical function substrate specificity, optional';


--
-- Name: COLUMN allele.activityvalue; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele.activityvalue IS 'Descriptor of activity score, optional';


--
-- Name: COLUMN allele.definitionid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele.definitionid IS 'The reference to the definition for this allele';


--
-- Name: COLUMN allele.citations; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele.citations IS 'An array of PubMed IDs use as citations for this functional assignment';


--
-- Name: COLUMN allele.strength; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele.strength IS 'The strength of evidence';


--
-- Name: COLUMN allele.functioncomments; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele.functioncomments IS 'Comments this functional assignment of this allele';


--
-- Name: COLUMN allele.inferredfrequency; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele.inferredfrequency IS 'Indicates (with "true") that the frequencies for this allele have been inferred by an algorithm that aggregates the frequencies for other alleles of this gene and is not based on direct data, defaults to false, should only be 1 per gene';


--
-- Name: allele_definition; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.allele_definition (
    id integer DEFAULT nextval('cpic.cpic_id'::regclass) NOT NULL,
    version integer DEFAULT 1,
    genesymbol character varying(50) NOT NULL,
    name text NOT NULL,
    pharmvarid character varying(50),
    matchesreferencesequence boolean DEFAULT false,
    structuralvariation boolean DEFAULT false
);


--
-- Name: TABLE allele_definition; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.allele_definition IS 'The definition for an allele of a gene';


--
-- Name: COLUMN allele_definition.id; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele_definition.id IS 'A synthetic numerical ID, auto-assigned, primary key';


--
-- Name: COLUMN allele_definition.genesymbol; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele_definition.genesymbol IS 'The HGNC symbol of the gene the allele is for, required';


--
-- Name: COLUMN allele_definition.name; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele_definition.name IS 'The name of this allele, required';


--
-- Name: COLUMN allele_definition.pharmvarid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele_definition.pharmvarid IS 'The PharmVar core allele ID for this allele';


--
-- Name: COLUMN allele_definition.matchesreferencesequence; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele_definition.matchesreferencesequence IS 'Indicates (with "true") the variants that define the named allele will match the reference sequence for the gene, defaults to false, should only be 1 per gene';


--
-- Name: COLUMN allele_definition.structuralvariation; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele_definition.structuralvariation IS 'Indicates whether this allele definition is a structural variant, default is false. If true, look in the pharmvarid field for the PharmVar ID that defines the structural variation.';


--
-- Name: allele_frequency; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.allele_frequency (
    alleleid integer NOT NULL,
    population integer NOT NULL,
    frequency numeric,
    label text,
    version integer DEFAULT 1
);


--
-- Name: TABLE allele_frequency; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.allele_frequency IS 'A frequency observation for a particular allele in a particular population';


--
-- Name: COLUMN allele_frequency.alleleid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele_frequency.alleleid IS 'The ID of the allele for this observation';


--
-- Name: COLUMN allele_frequency.population; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele_frequency.population IS 'The ID of the population for this observation';


--
-- Name: COLUMN allele_frequency.frequency; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele_frequency.frequency IS 'The numeric representation of this frequency';


--
-- Name: COLUMN allele_frequency.label; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele_frequency.label IS 'The textual label for this frequency, "-" means no observation made';


--
-- Name: COLUMN allele_frequency.version; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele_frequency.version IS 'The version number, iterates on modification';


--
-- Name: pair; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.pair (
    pairid integer DEFAULT nextval('cpic.cpic_id'::regclass) NOT NULL,
    genesymbol character varying(20),
    drugid character varying(20),
    guidelineid integer,
    usedforrecommendation boolean DEFAULT false,
    version integer DEFAULT 1,
    cpiclevel text NOT NULL,
    clinpgxlevel character varying(5),
    pgxtesting text,
    citations text[],
    removed boolean DEFAULT false,
    removeddate date,
    removedreason text,
    CONSTRAINT valid_cpiclevel_check CHECK ((cpiclevel = ANY (ARRAY[('A'::character varying)::text, ('A/B'::character varying)::text, ('B'::character varying)::text, ('B/C'::character varying)::text, ('C'::character varying)::text, ('C/D'::character varying)::text, ('D'::character varying)::text, ('Retired'::character varying)::text]))),
    CONSTRAINT valid_pgkblevel_check CHECK (((clinpgxlevel)::text = ANY (ARRAY[('1A'::character varying)::text, ('1B'::character varying)::text, ('2A'::character varying)::text, ('2B'::character varying)::text, ('3'::character varying)::text, ('4'::character varying)::text]))),
    CONSTRAINT valid_pmids CHECK ((array_to_string(citations, ''::text) ~ '\d+'::text)),
    CONSTRAINT valid_used_check CHECK (((NOT usedforrecommendation) OR (guidelineid IS NOT NULL)))
);


--
-- Name: TABLE pair; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.pair IS 'A pair of a gene and a drug that is notable to CPIC';


--
-- Name: COLUMN pair.pairid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair.pairid IS 'A synthetic numerical id, automatically assigned, primary key';


--
-- Name: COLUMN pair.genesymbol; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair.genesymbol IS 'The HGNC symbol of the gene in this pair, required';


--
-- Name: COLUMN pair.drugid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair.drugid IS 'The ID of the drug in this pair, required';


--
-- Name: COLUMN pair.guidelineid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair.guidelineid IS 'The ID of a guideline this pair is described in, optional';


--
-- Name: COLUMN pair.usedforrecommendation; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair.usedforrecommendation IS 'Whether the gene is used for recommendation lookup for the drug if this pair is part of a guideline, default false';


--
-- Name: COLUMN pair.version; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair.version IS 'The version number, iterates on modification';


--
-- Name: COLUMN pair.cpiclevel; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair.cpiclevel IS 'The CPIC level of this pair, required';


--
-- Name: COLUMN pair.clinpgxlevel; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair.clinpgxlevel IS 'The top level of PharmGKB Clinical Annotation for this pair, optional';


--
-- Name: COLUMN pair.pgxtesting; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair.pgxtesting IS 'The top level of PGx testing recommendation from PharmGKB label annotations, optional';


--
-- Name: COLUMN pair.citations; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair.citations IS 'The PMID citations in an array for this pair, optional';


--
-- Name: COLUMN pair.removed; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair.removed IS 'Has this pair been "removed", eg is no longer a valid pair, default false';


--
-- Name: COLUMN pair.removeddate; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair.removeddate IS 'If removed, when was this pair "removed"';


--
-- Name: COLUMN pair.removedreason; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair.removedreason IS 'If removed, why was this pair "removed"';


--
-- Name: allele_guideline_view; Type: VIEW; Schema: cpic; Owner: -
--

CREATE VIEW cpic.allele_guideline_view AS
 SELECT DISTINCT a.genesymbol,
    a.name AS allele_name,
    g.name AS guideline_name,
    g.url AS guideline_url
   FROM ((cpic.allele a
     JOIN cpic.pair p ON (((a.genesymbol)::text = (p.genesymbol)::text)))
     JOIN cpic.guideline g ON ((g.id = p.guidelineid)))
  WHERE (a.clinicalfunctionalstatus IS NOT NULL);


--
-- Name: VIEW allele_guideline_view; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON VIEW cpic.allele_guideline_view IS 'A combination of alleles and the guidelines they appear in';


--
-- Name: COLUMN allele_guideline_view.genesymbol; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele_guideline_view.genesymbol IS 'The HGNC symbol of the gene';


--
-- Name: COLUMN allele_guideline_view.allele_name; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele_guideline_view.allele_name IS 'The name of the allele';


--
-- Name: COLUMN allele_guideline_view.guideline_name; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele_guideline_view.guideline_name IS 'The name of the guideline this allele appears in';


--
-- Name: COLUMN allele_guideline_view.guideline_url; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele_guideline_view.guideline_url IS 'The URL to the guideline';


--
-- Name: allele_location_value; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.allele_location_value (
    alleledefinitionid integer NOT NULL,
    locationid integer NOT NULL,
    variantallele text NOT NULL,
    version integer DEFAULT 1
);


--
-- Name: TABLE allele_location_value; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.allele_location_value IS 'The change at a specific location for a specific allele';


--
-- Name: COLUMN allele_location_value.alleledefinitionid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele_location_value.alleledefinitionid IS 'The reference to the allele this variant is on';


--
-- Name: COLUMN allele_location_value.locationid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele_location_value.locationid IS 'The reference to the location this variant is for';


--
-- Name: COLUMN allele_location_value.variantallele; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele_location_value.variantallele IS 'The allele of this location for the allele';


--
-- Name: COLUMN allele_location_value.version; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele_location_value.version IS 'The version number, iterates on modification';


--
-- Name: change_log; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.change_log (
    date date NOT NULL,
    type text NOT NULL,
    entityid text,
    note text NOT NULL,
    version integer DEFAULT 1,
    deployedrelease text
);


--
-- Name: TABLE change_log; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.change_log IS 'A dated freeform text description of a change made to a type of information and optionally for a specific entity';


--
-- Name: COLUMN change_log.date; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.change_log.date IS 'The date the log note is applicable';


--
-- Name: COLUMN change_log.type; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.change_log.type IS 'The type of data this log message is about';


--
-- Name: COLUMN change_log.entityid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.change_log.entityid IS 'Optional, the specific entity this note is about. For example, could be a gene symbol or drug ID';


--
-- Name: COLUMN change_log.note; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.change_log.note IS 'The freeform text note about what the change was';


--
-- Name: COLUMN change_log.version; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.change_log.version IS 'The version number, iterates on modification';


--
-- Name: COLUMN change_log.deployedrelease; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.change_log.deployedrelease IS 'The release this change was deployed with';


--
-- Name: gene; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.gene (
    symbol character varying(20) NOT NULL,
    chr character varying(20),
    genesequenceid text,
    proteinsequenceid text,
    chromosequenceid text,
    mrnasequenceid text,
    hgncid text,
    ncbiid text,
    ensemblid text,
    clinpgxid text,
    frequencymethods text,
    lookupmethod text DEFAULT 'PHENOTYPE'::text,
    version integer DEFAULT 1,
    notesondiplotype text,
    url text,
    functionmethods text,
    notesonallelenaming text,
    includephenotypefrequencies boolean DEFAULT true NOT NULL,
    includediplotypefrequencies boolean DEFAULT true NOT NULL,
    CONSTRAINT gene_chr_check CHECK (((chr)::text ~ '^chr\S+$'::text)),
    CONSTRAINT gene_chromosequenceid_check CHECK ((chromosequenceid ~ '^(NC_\S+)?$'::text)),
    CONSTRAINT gene_ensemblid_check CHECK ((ensemblid ~ '^(ENSG\d+)?$'::text)),
    CONSTRAINT gene_genesequenceid_check CHECK ((genesequenceid ~ '^(NG_\S+)?$'::text)),
    CONSTRAINT gene_hgncid_check CHECK ((hgncid ~ '^(HGNC:\d+)?$'::text)),
    CONSTRAINT gene_mrnasequenceid_check CHECK ((mrnasequenceid ~ '^(NM_\S+)?$'::text)),
    CONSTRAINT gene_pharmgkbid_check CHECK ((clinpgxid ~ '^(PA\d+)?$'::text)),
    CONSTRAINT gene_proteinsequenceid_check CHECK ((proteinsequenceid ~ '^(NP_\S+)?$'::text))
);


--
-- Name: TABLE gene; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.gene IS 'Gene information with a primary key of the approved HGNC symbol for the gene. This means any gene used in the table must be approved by HGNC.';


--
-- Name: COLUMN gene.symbol; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene.symbol IS 'Approved HGNC symbol, primary key.';


--
-- Name: COLUMN gene.chr; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene.chr IS 'Chromosome symbol. In the form chr##, where ## is the number or X/Y.';


--
-- Name: COLUMN gene.genesequenceid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene.genesequenceid IS 'The RefSeq ID for the sequence that represents this gene, starts with "NG_". No version suffix.';


--
-- Name: COLUMN gene.proteinsequenceid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene.proteinsequenceid IS 'The RefSeq ID for the sequence that represents the protein product of this gene, starts with "NP_". No version suffix.';


--
-- Name: COLUMN gene.chromosequenceid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene.chromosequenceid IS 'The RefSeq ID for the sequence that represents the chromosome this gene is on, starts with "NC_". No version suffix.';


--
-- Name: COLUMN gene.mrnasequenceid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene.mrnasequenceid IS 'The RefSeq ID for the sequence that represents the translation of this gene, starts with "NM_". No version suffix.';


--
-- Name: COLUMN gene.hgncid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene.hgncid IS 'The HGNC numerical ID number for this gene prefixed by "HGNC:"';


--
-- Name: COLUMN gene.ncbiid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene.ncbiid IS 'The NCBI Gene (Entrez) ID number for this gene';


--
-- Name: COLUMN gene.ensemblid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene.ensemblid IS 'The Ensembl ID for this gene';


--
-- Name: COLUMN gene.clinpgxid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene.clinpgxid IS 'The ID for this gene in ClinPGx';


--
-- Name: COLUMN gene.frequencymethods; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene.frequencymethods IS 'Text documentation of the methods and caveats for allele frequency data';


--
-- Name: COLUMN gene.lookupmethod; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene.lookupmethod IS 'The way to lookup information about diplotypes of this gene, should use ACTIVITY_SCORE, PHENOTYPE, or ALLELE_STATUS';


--
-- Name: COLUMN gene.notesondiplotype; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene.notesondiplotype IS 'Optional notes about the diplotypes of the gene';


--
-- Name: COLUMN gene.includephenotypefrequencies; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene.includephenotypefrequencies IS 'if allele frequencies exist for this gene, whether to calculate and display phenotype-level frequencies. a true value does not imply existence frequency data';


--
-- Name: COLUMN gene.includediplotypefrequencies; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene.includediplotypefrequencies IS 'if allele frequencies exist for this gene, whether to calculate and display diplotype-level frequencies. a true value does not imply existence frequency data';


--
-- Name: change_log_view; Type: VIEW; Schema: cpic; Owner: -
--

CREATE VIEW cpic.change_log_view AS
 WITH x AS (
         SELECT gene.symbol AS entityid,
            gene.symbol AS entityname
           FROM cpic.gene
        UNION ALL
         SELECT drug.drugid AS entityid,
            drug.name AS entityname
           FROM cpic.drug
        )
 SELECT l.date,
    l.type,
    x.entityname,
    l.note,
    l.deployedrelease
   FROM (cpic.change_log l
     LEFT JOIN x ON ((l.entityid = (x.entityid)::text)));


--
-- Name: VIEW change_log_view; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON VIEW cpic.change_log_view IS 'This view of the change_log table add the entity name to make it more readable';


--
-- Name: gene_result; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.gene_result (
    id integer DEFAULT nextval('cpic.cpic_id'::regclass) NOT NULL,
    genesymbol character varying(50) NOT NULL,
    result text NOT NULL,
    activityscore text,
    ehrpriority text,
    consultationtext text,
    version integer DEFAULT 1,
    frequency jsonb
);


--
-- Name: TABLE gene_result; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.gene_result IS 'Possible phenotype values for a gene. The gene + phenotype + activity score should be unique.';


--
-- Name: COLUMN gene_result.id; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene_result.id IS 'A synthetic numerical ID, auto-assigned, primary key';


--
-- Name: COLUMN gene_result.genesymbol; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene_result.genesymbol IS 'The HGNC symbol of the gene in this pair, required';


--
-- Name: COLUMN gene_result.result; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene_result.result IS 'The result for a gene, can either be a phenotype or "allele status" depending on the lookup method for the gene (see lookupMethod in gene table), required';


--
-- Name: COLUMN gene_result.activityscore; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene_result.activityscore IS 'Activity score, optional';


--
-- Name: COLUMN gene_result.ehrpriority; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene_result.ehrpriority IS 'EHR Priority Result, optional';


--
-- Name: COLUMN gene_result.consultationtext; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene_result.consultationtext IS 'Consultation (Interpretation) Text Provided with Test Result';


--
-- Name: COLUMN gene_result.frequency; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene_result.frequency IS 'JSON map of frequencies for this gene result with keys being biogeographical groups';


--
-- Name: gene_result_diplotype; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.gene_result_diplotype (
    id integer DEFAULT nextval('cpic.cpic_id'::regclass) NOT NULL,
    functionphenotypeid integer NOT NULL,
    diplotype text NOT NULL,
    diplotypekey jsonb NOT NULL,
    frequency jsonb
);


--
-- Name: TABLE gene_result_diplotype; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.gene_result_diplotype IS 'Specific diplotypes that are associated with a gene result. This table is a child of gene_result_lookup and distantly of gene_result';


--
-- Name: COLUMN gene_result_diplotype.id; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene_result_diplotype.id IS 'A synthetic numerical ID, auto-assigned, primary key';


--
-- Name: COLUMN gene_result_diplotype.functionphenotypeid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene_result_diplotype.functionphenotypeid IS 'An ID referencing a gene_result_lookup record, required';


--
-- Name: COLUMN gene_result_diplotype.diplotype; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene_result_diplotype.diplotype IS 'A diplotype for the gene in the form Allele1/Allele2, required';


--
-- Name: COLUMN gene_result_diplotype.diplotypekey; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene_result_diplotype.diplotypekey IS 'A normalized JSON version of the diplotype for use in lookups. Should be an object with the allele names as properties and the counts as the values. Required';


--
-- Name: gene_result_lookup; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.gene_result_lookup (
    id integer DEFAULT nextval('cpic.cpic_id'::regclass) NOT NULL,
    phenotypeid integer NOT NULL,
    lookupkey jsonb NOT NULL,
    function1 text,
    function2 text,
    activityvalue1 text,
    activityvalue2 text,
    totalactivityscore text,
    description text
);


--
-- Name: TABLE gene_result_lookup; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.gene_result_lookup IS 'Gene descriptions that, when combined, link to a gene result. This table is a child of gene_result.';


--
-- Name: COLUMN gene_result_lookup.id; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene_result_lookup.id IS 'A synthetic numerical ID, auto-assigned, primary key';


--
-- Name: COLUMN gene_result_lookup.phenotypeid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene_result_lookup.phenotypeid IS 'An ID referencing the gene_result this is associated with, required';


--
-- Name: COLUMN gene_result_lookup.lookupkey; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene_result_lookup.lookupkey IS 'A normalized JSON format of the data used to lookup a diplotype. The keys of this field are either the functions, activity scores, or allele statuses depending on what the gene requires. Required.';


--
-- Name: COLUMN gene_result_lookup.function1; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene_result_lookup.function1 IS 'The first allele function';


--
-- Name: COLUMN gene_result_lookup.function2; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene_result_lookup.function2 IS 'The second allele function';


--
-- Name: COLUMN gene_result_lookup.activityvalue1; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene_result_lookup.activityvalue1 IS 'The activity score for the first allele function';


--
-- Name: COLUMN gene_result_lookup.activityvalue2; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene_result_lookup.activityvalue2 IS 'The activity score for the second allele function';


--
-- Name: COLUMN gene_result_lookup.totalactivityscore; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene_result_lookup.totalactivityscore IS 'The sum activity score for the functions';


--
-- Name: COLUMN gene_result_lookup.description; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene_result_lookup.description IS 'A description of the diplotypes associated with this phenotype';


--
-- Name: diplotype; Type: VIEW; Schema: cpic; Owner: -
--

CREATE VIEW cpic.diplotype AS
 SELECT gp.genesymbol,
    d.diplotype,
    pf.function1,
    pf.function2,
    pf.activityvalue1,
    pf.activityvalue2,
    pf.totalactivityscore,
    pf.description,
    d.diplotypekey,
    gp.result AS generesult,
    gp.ehrpriority,
    gp.consultationtext,
    json_build_object(gp.genesymbol,
        CASE
            WHEN (g.lookupmethod = 'ACTIVITY_SCORE'::text) THEN pf.totalactivityscore
            ELSE gp.result
        END) AS lookupkey
   FROM (((cpic.gene_result_diplotype d
     JOIN cpic.gene_result_lookup pf ON ((d.functionphenotypeid = pf.id)))
     JOIN cpic.gene_result gp ON ((pf.phenotypeid = gp.id)))
     JOIN cpic.gene g ON (((gp.genesymbol)::text = (g.symbol)::text)));


--
-- Name: VIEW diplotype; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON VIEW cpic.diplotype IS 'A combination of gene_result and gene_result_diplotype that allows you to easily query by diplotype and see the phenotype-related data for it';


--
-- Name: COLUMN diplotype.genesymbol; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.diplotype.genesymbol IS 'The HGNC symbol of the gene in this pair, required';


--
-- Name: COLUMN diplotype.diplotype; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.diplotype.diplotype IS 'A diplotype for the gene in the form Allele1/Allele2, required';


--
-- Name: COLUMN diplotype.function1; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.diplotype.function1 IS 'A functional assignment of one of the alleles, optional';


--
-- Name: COLUMN diplotype.function2; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.diplotype.function2 IS 'A functional assignment of one of the alleles, optional';


--
-- Name: COLUMN diplotype.activityvalue1; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.diplotype.activityvalue1 IS 'An activity value assignment of one of the alleles, optional';


--
-- Name: COLUMN diplotype.activityvalue2; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.diplotype.activityvalue2 IS 'An activity value assignment of one of the alleles, optional';


--
-- Name: COLUMN diplotype.totalactivityscore; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.diplotype.totalactivityscore IS 'The total Activity Score number, optional';


--
-- Name: COLUMN diplotype.description; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.diplotype.description IS 'The long-form description of the diplotype';


--
-- Name: COLUMN diplotype.diplotypekey; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.diplotype.diplotypekey IS 'A normalized version of the diplotype that can be used for DB lookups';


--
-- Name: COLUMN diplotype.generesult; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.diplotype.generesult IS 'The result for a gene, can either be a phenotype or "allele status" depending on the lookup method for the gene (see lookupMethod in gene table), required';


--
-- Name: COLUMN diplotype.lookupkey; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.diplotype.lookupkey IS 'A normalized version of the gene phenotype that can be used for recommendation or test alert lookup';


--
-- Name: data_progress; Type: VIEW; Schema: cpic; Owner: -
--

CREATE VIEW cpic.data_progress AS
 SELECT 'Gene'::text AS object_class,
    'Allele Definition Data'::text AS data_type,
    allele_definition.genesymbol AS object_name,
    count(*) AS n
   FROM cpic.allele_definition
  GROUP BY allele_definition.genesymbol
UNION ALL
 SELECT 'Gene'::text AS object_class,
    'Allele Functionality Data'::text AS data_type,
    a.genesymbol AS object_name,
    count(*) AS n
   FROM cpic.allele a
  WHERE (a.clinicalfunctionalstatus IS NOT NULL)
  GROUP BY a.genesymbol
UNION ALL
 SELECT 'Gene'::text AS object_class,
    'Diplotype to Phenotype Data'::text AS data_type,
    diplotype.genesymbol AS object_name,
    count(*) AS n
   FROM cpic.diplotype
  GROUP BY diplotype.genesymbol
UNION ALL
 SELECT 'Gene'::text AS object_class,
    'Frequency Data'::text AS data_type,
    a.genesymbol AS object_name,
    count(*) AS n
   FROM (cpic.allele_frequency f
     JOIN cpic.allele a ON ((f.alleleid = a.id)))
  GROUP BY a.genesymbol
UNION ALL
 SELECT 'Gene'::text AS object_class,
    'Gene CDS Data'::text AS data_type,
    gene_result.genesymbol AS object_name,
    count(*) AS n
   FROM cpic.gene_result
  WHERE (gene_result.consultationtext IS NOT NULL)
  GROUP BY gene_result.genesymbol
UNION ALL
 SELECT 'Gene'::text AS object_class,
    'Gene Phenotype Data'::text AS data_type,
    g.genesymbol AS object_name,
    count(*) AS n
   FROM (cpic.gene_result g
     JOIN cpic.gene_result_lookup pf ON ((g.id = pf.phenotypeid)))
  GROUP BY g.genesymbol
UNION ALL
 SELECT 'Gene'::text AS object_class,
    'PharmVar Allele IDs'::text AS data_type,
    a.genesymbol AS object_name,
    count(*) AS n
   FROM cpic.allele_definition a
  WHERE (a.pharmvarid IS NOT NULL)
  GROUP BY a.genesymbol
UNION ALL
 SELECT 'Drug'::text AS object_class,
    'Flowcharts'::text AS data_type,
    drug.name AS object_name,
    count(*) AS n
   FROM cpic.drug
  WHERE (drug.flowchart IS NOT NULL)
  GROUP BY drug.name
UNION ALL
 SELECT 'Drug'::text AS object_class,
    'Table 2 Recommendations'::text AS data_type,
    d.name AS object_name,
    count(DISTINCT r.id) AS n
   FROM (cpic.recommendation r
     JOIN cpic.drug d ON (((r.drugid)::text = (d.drugid)::text)))
  GROUP BY d.name
UNION ALL
 SELECT 'Drug'::text AS object_class,
    'Drug Test Alerts'::text AS data_type,
    d.name AS object_name,
    count(DISTINCT t.id) AS n
   FROM (cpic.test_alert t
     JOIN cpic.drug d ON (((t.drugid)::text = (d.drugid)::text)))
  GROUP BY d.name
UNION ALL
 SELECT 'Drug'::text AS object_class,
    'Guideline'::text AS data_type,
    d.name AS object_name,
    count(DISTINCT g.id) AS n
   FROM ((cpic.guideline g
     JOIN cpic.pair p ON ((g.id = p.guidelineid)))
     JOIN cpic.drug d ON (((p.drugid)::text = (d.drugid)::text)))
  GROUP BY d.name;


--
-- Name: file_artifact; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.file_artifact (
    id integer DEFAULT nextval('cpic.cpic_id'::regclass) NOT NULL,
    entityids text[],
    type text NOT NULL,
    filename text NOT NULL,
    url text
);


--
-- Name: TABLE file_artifact; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.file_artifact IS 'File artifact information. Each entry is a different file artifact generated by the system';


--
-- Name: COLUMN file_artifact.id; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.file_artifact.id IS 'A synthetic numerical ID, auto-assigned, primary key';


--
-- Name: COLUMN file_artifact.entityids; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.file_artifact.entityids IS 'The IDs of the entities the file is for, required';


--
-- Name: COLUMN file_artifact.type; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.file_artifact.type IS 'The type of file';


--
-- Name: COLUMN file_artifact.filename; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.file_artifact.filename IS 'The name of the file (no path)';


--
-- Name: COLUMN file_artifact.url; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.file_artifact.url IS 'The permanent URL of the current version of this file';


--
-- Name: file_artifact_history; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.file_artifact_history (
    id integer DEFAULT nextval('cpic.cpic_id'::regclass) NOT NULL,
    fileid integer NOT NULL,
    source text NOT NULL,
    changedate timestamp without time zone DEFAULT CURRENT_TIMESTAMP NOT NULL,
    changemessage text
);


--
-- Name: TABLE file_artifact_history; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.file_artifact_history IS 'History information for a related file artifact';


--
-- Name: COLUMN file_artifact_history.id; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.file_artifact_history.id IS 'A synthetic numerical ID, auto-assigned, primary key';


--
-- Name: COLUMN file_artifact_history.fileid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.file_artifact_history.fileid IS 'The ID of the related File Artifact';


--
-- Name: COLUMN file_artifact_history.source; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.file_artifact_history.source IS 'Where this history message originated from';


--
-- Name: COLUMN file_artifact_history.changedate; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.file_artifact_history.changedate IS 'The date the change was applied';


--
-- Name: COLUMN file_artifact_history.changemessage; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.file_artifact_history.changemessage IS 'A message describing the change that occurred';


--
-- Name: file_note; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.file_note (
    type text NOT NULL,
    entityid text,
    note text NOT NULL,
    ordinal integer NOT NULL,
    version integer DEFAULT 1
);


--
-- Name: TABLE file_note; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.file_note IS 'An ordered note that should appear with the type of information specified';


--
-- Name: COLUMN file_note.type; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.file_note.type IS 'The type of information this note is about';


--
-- Name: COLUMN file_note.entityid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.file_note.entityid IS 'Optional, the specific entity this note is about. For example, could be a gene symbol or drug ID';


--
-- Name: COLUMN file_note.note; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.file_note.note IS 'The freeform text note about the type/entity';


--
-- Name: COLUMN file_note.ordinal; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.file_note.ordinal IS 'The index number for ordering notes of a given type/entity';


--
-- Name: COLUMN file_note.version; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.file_note.version IS 'The version number, iterates on modification';


--
-- Name: file_status; Type: VIEW; Schema: cpic; Owner: -
--

CREATE VIEW cpic.file_status AS
 SELECT a.id,
    a.entityids,
    a.type,
    a.filename,
    a.url,
    history.latest_change
   FROM (cpic.file_artifact a
     LEFT JOIN ( SELECT h.fileid,
            max(h.changedate) AS latest_change
           FROM cpic.file_artifact_history h
          GROUP BY h.fileid) history ON ((a.id = history.fileid)))
  ORDER BY a.type, a.filename;


--
-- Name: flyway_schema_history; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.flyway_schema_history (
    installed_rank integer NOT NULL,
    version character varying(50),
    description character varying(200) NOT NULL,
    type character varying(20) NOT NULL,
    script character varying(1000) NOT NULL,
    checksum integer,
    installed_by character varying(100) NOT NULL,
    installed_on timestamp without time zone DEFAULT now() NOT NULL,
    execution_time integer NOT NULL,
    success boolean NOT NULL
);


--
-- Name: guideline_summary_view; Type: VIEW; Schema: cpic; Owner: -
--

CREATE VIEW cpic.guideline_summary_view AS
 SELECT g.name AS guideline_name,
    g.url AS guideline_url,
    array_agg(DISTINCT d.name) AS drugs,
    jsonb_agg(DISTINCT jsonb_build_object('symbol', p.genesymbol, 'url', (('https://cpicpgx.org/gene/'::text || lower((p.genesymbol)::text)) || '/'::text))) AS genes
   FROM ((cpic.guideline g
     JOIN cpic.pair p ON ((g.id = p.guidelineid)))
     JOIN cpic.drug d ON (((p.drugid)::text = (d.drugid)::text)))
  GROUP BY g.name, g.url;


--
-- Name: VIEW guideline_summary_view; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON VIEW cpic.guideline_summary_view IS 'This view lists guidelines and the genes and drugs that are associated with them';


--
-- Name: COLUMN guideline_summary_view.guideline_name; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.guideline_summary_view.guideline_name IS 'The title of the guideline';


--
-- Name: COLUMN guideline_summary_view.guideline_url; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.guideline_summary_view.guideline_url IS 'The URL of the guideline on the CPIC website';


--
-- Name: COLUMN guideline_summary_view.drugs; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.guideline_summary_view.drugs IS 'An array of drug names associated with this guideline';


--
-- Name: COLUMN guideline_summary_view.genes; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.guideline_summary_view.genes IS 'An array of gene data associated with this guideline, each object will have a symbol and a URL for the gene on the CPIC website';


--
-- Name: pair_view; Type: VIEW; Schema: cpic; Owner: -
--

CREATE VIEW cpic.pair_view AS
 SELECT p.pairid,
    p.drugid,
    d.name AS drugname,
    p.genesymbol,
    g.name AS guidelinename,
    g.url AS guidelineurl,
    p.cpiclevel,
    p.clinpgxlevel,
    p.pgxtesting,
    p.citations AS pmids,
        CASE
            WHEN (p.usedforrecommendation AND (p.guidelineid IS NOT NULL)) THEN 'Yes'::text
            WHEN ((NOT p.usedforrecommendation) AND (p.guidelineid IS NOT NULL)) THEN 'No'::text
            ELSE 'n/a'::text
        END AS usedforrecommendation,
        CASE
            WHEN (p.guidelineid IS NULL) THEN true
            ELSE false
        END AS provisional
   FROM ((cpic.pair p
     JOIN cpic.drug d ON (((p.drugid)::text = (d.drugid)::text)))
     LEFT JOIN cpic.guideline g ON ((p.guidelineid = g.id)))
  WHERE (p.removed IS FALSE);


--
-- Name: VIEW pair_view; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON VIEW cpic.pair_view IS 'This pairs view combines information from the pair, drug, and guideline tables to make a more readable view of pair data. This also limits result to pairs which have NOT been removed.';


--
-- Name: COLUMN pair_view.pairid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair_view.pairid IS 'The primary key ID of this pair';


--
-- Name: COLUMN pair_view.drugid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair_view.drugid IS 'The ID of the drug in the pair';


--
-- Name: COLUMN pair_view.drugname; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair_view.drugname IS 'The name of the drug in the pair';


--
-- Name: COLUMN pair_view.genesymbol; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair_view.genesymbol IS 'The symbol of the drug in the pair';


--
-- Name: COLUMN pair_view.guidelinename; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair_view.guidelinename IS 'The name for the guideline of this pair';


--
-- Name: COLUMN pair_view.guidelineurl; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair_view.guidelineurl IS 'The URL for the guideline of this pair';


--
-- Name: COLUMN pair_view.cpiclevel; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair_view.cpiclevel IS 'The CPIC-assigned level of the pair';


--
-- Name: COLUMN pair_view.clinpgxlevel; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair_view.clinpgxlevel IS 'The top level of ClinPGx Summary Annotation of the pair';


--
-- Name: COLUMN pair_view.pgxtesting; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair_view.pgxtesting IS 'The testing level of the label annotation from ClinPGx for this pair';


--
-- Name: COLUMN pair_view.pmids; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair_view.pmids IS 'The PMIDs for guideline publications of this pair';


--
-- Name: COLUMN pair_view.provisional; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair_view.provisional IS 'The CPIC level assigned to this pair is provisional, true if this pair is not part of a guideline';


--
-- Name: population; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.population (
    id integer DEFAULT nextval('cpic.cpic_id'::regclass) NOT NULL,
    publicationid integer,
    ethnicity text NOT NULL,
    population text,
    populationinfo text,
    subjecttype text,
    subjectcount integer DEFAULT 0,
    version integer DEFAULT 1
);


--
-- Name: TABLE population; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.population IS 'A population description of a group of subjects';


--
-- Name: COLUMN population.id; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.population.id IS 'A synthetic primary key ID';


--
-- Name: COLUMN population.publicationid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.population.publicationid IS 'A reference to a publication';


--
-- Name: COLUMN population.ethnicity; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.population.ethnicity IS 'The major ethnicity grouping of this population';


--
-- Name: COLUMN population.population; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.population.population IS 'The descriptive name of this population, optional';


--
-- Name: COLUMN population.populationinfo; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.population.populationinfo IS 'Further information about this population, optional';


--
-- Name: COLUMN population.subjecttype; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.population.subjecttype IS 'Information about the types of subjects in this population';


--
-- Name: COLUMN population.subjectcount; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.population.subjectcount IS 'The total number of subjects in this population';


--
-- Name: COLUMN population.version; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.population.version IS 'The version number, iterates on modification';


--
-- Name: population_frequency_view; Type: VIEW; Schema: cpic; Owner: -
--

CREATE VIEW cpic.population_frequency_view AS
 WITH x AS (
         SELECT a.id AS alleleid,
            a.genesymbol,
            a.name,
            f.key AS population_group,
                CASE
                    WHEN (jsonb_typeof(f.value) = 'null'::text) THEN NULL::numeric
                    ELSE (f.value)::numeric
                END AS freq_weighted_avg
           FROM (cpic.allele a
             CROSS JOIN LATERAL jsonb_each(a.frequency) f(key, value))
        ), y AS (
         SELECT f.alleleid,
            p.ethnicity,
            max(f.frequency) AS freq_max,
            min(f.frequency) AS freq_min,
            avg(f.frequency) AS freq_avg,
            sum(p.subjectcount) AS subjectcount
           FROM (cpic.population p
             JOIN cpic.allele_frequency f ON ((p.id = f.population)))
          GROUP BY f.alleleid, p.ethnicity
        )
 SELECT x.genesymbol,
    x.name,
    x.population_group,
    y.subjectcount,
    x.freq_weighted_avg,
    y.freq_avg,
    y.freq_max,
    y.freq_min
   FROM (x
     JOIN y ON (((x.alleleid = y.alleleid) AND (x.population_group = y.ethnicity))));


--
-- Name: VIEW population_frequency_view; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON VIEW cpic.population_frequency_view IS 'A summary of frequency data by allele and major population group';


--
-- Name: COLUMN population_frequency_view.genesymbol; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.population_frequency_view.genesymbol IS 'The HGNC symbol of the gene';


--
-- Name: COLUMN population_frequency_view.name; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.population_frequency_view.name IS 'The allele name';


--
-- Name: COLUMN population_frequency_view.population_group; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.population_frequency_view.population_group IS 'The major grouping of population';


--
-- Name: COLUMN population_frequency_view.subjectcount; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.population_frequency_view.subjectcount IS 'The count of subjects assigned the population group for the given allele';


--
-- Name: COLUMN population_frequency_view.freq_weighted_avg; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.population_frequency_view.freq_weighted_avg IS 'The average frequency weighted by total subjects';


--
-- Name: COLUMN population_frequency_view.freq_avg; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.population_frequency_view.freq_avg IS 'The unweighted average frequency (use with caution)';


--
-- Name: COLUMN population_frequency_view.freq_max; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.population_frequency_view.freq_max IS 'The maximum frequency observed';


--
-- Name: COLUMN population_frequency_view.freq_min; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.population_frequency_view.freq_min IS 'The minimum frequency observed';


--
-- Name: publication; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.publication (
    id integer DEFAULT nextval('cpic.cpic_id'::regclass) NOT NULL,
    guidelineid integer,
    title text,
    authors text[],
    journal text,
    month integer,
    page character varying(50),
    volume character varying(50),
    year integer,
    pmid text,
    pmcid text,
    doi text,
    url text,
    version integer DEFAULT 1,
    highlightedonsite boolean DEFAULT false,
    fulltextfile text
);


--
-- Name: TABLE publication; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.publication IS 'Documents published to an external resource';


--
-- Name: COLUMN publication.id; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.publication.id IS 'A synthetic numerical ID, auto-assigned, primary key';


--
-- Name: COLUMN publication.guidelineid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.publication.guidelineid IS 'The ID for the guideline this publication is about, optional';


--
-- Name: COLUMN publication.pmid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.publication.pmid IS 'The PubMed identifier for this publication';


--
-- Name: COLUMN publication.pmcid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.publication.pmcid IS 'The PubMed Central identifier for this publication';


--
-- Name: COLUMN publication.doi; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.publication.doi IS 'The Document Object Identifier (DOI) for this publication';


--
-- Name: COLUMN publication.url; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.publication.url IS 'The URL for this publication';


--
-- Name: COLUMN publication.highlightedonsite; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.publication.highlightedonsite IS 'true means this publication will show in the CPIC site Publications page, defaults to false';


--
-- Name: COLUMN publication.fulltextfile; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.publication.fulltextfile IS 'publicly-accessible URL to full text of publication';


--
-- Name: publication_supplement; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.publication_supplement (
    id integer DEFAULT nextval('cpic.cpic_id'::regclass) NOT NULL,
    publicationid integer NOT NULL,
    description text,
    url text NOT NULL,
    version integer DEFAULT 1
);


--
-- Name: TABLE publication_supplement; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.publication_supplement IS 'A table to hold optional supplemental files for publications';


--
-- Name: COLUMN publication_supplement.id; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.publication_supplement.id IS 'A synthetic numerical ID, primary key';


--
-- Name: COLUMN publication_supplement.publicationid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.publication_supplement.publicationid IS 'A foreign-key reference to the publication this is a supplement for';


--
-- Name: COLUMN publication_supplement.description; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.publication_supplement.description IS 'An optional free text description of the supplemental file';


--
-- Name: COLUMN publication_supplement.url; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.publication_supplement.url IS 'The publicly-accessible URL to the supplemental file';


--
-- Name: COLUMN publication_supplement.version; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.publication_supplement.version IS 'The version number, iterates on modification';


--
-- Name: recommendation_alleles_view; Type: VIEW; Schema: cpic; Owner: -
--

CREATE VIEW cpic.recommendation_alleles_view AS
 SELECT a.genesymbol,
    g.chr,
    g.lookupmethod,
    array_agg(DISTINCT a.name ORDER BY a.name) AS alleles,
    count(DISTINCT a.name) AS allele_count
   FROM (cpic.allele a
     JOIN cpic.gene g ON (((a.genesymbol)::text = (g.symbol)::text)))
  WHERE ((a.clinicalfunctionalstatus IS NOT NULL) AND (g.lookupmethod <> 'ALLELE_STATUS'::text))
  GROUP BY a.genesymbol, g.chr, g.lookupmethod
UNION
 SELECT g.symbol AS genesymbol,
    g.chr,
    g.lookupmethod,
    array_agg(DISTINCT a.value ORDER BY a.value) AS alleles,
    count(DISTINCT a.value) AS allele_count
   FROM (cpic.recommendation r
     JOIN cpic.drug d ON (((r.drugid)::text = (d.drugid)::text))),
    (LATERAL jsonb_each_text(r.lookupkey) a(key, value)
     JOIN cpic.gene g ON ((a.key = (g.symbol)::text)))
  WHERE ((r.allelestatus IS NOT NULL) AND (g.lookupmethod = 'ALLELE_STATUS'::text) AND (upper(a.value) !~~ '%NO%RESULT%'::text))
  GROUP BY g.symbol, g.chr, g.lookupmethod;


--
-- Name: VIEW recommendation_alleles_view; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON VIEW cpic.recommendation_alleles_view IS 'A list of genes that are used for recommendation lookup and the alleles to use for those lookups';


--
-- Name: sequence_location; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.sequence_location (
    id integer DEFAULT nextval('cpic.cpic_id'::regclass) NOT NULL,
    version integer DEFAULT 1,
    name text,
    chromosomelocation text,
    genelocation text,
    proteinlocation text,
    genesymbol character varying(50) NOT NULL,
    dbsnpid text,
    "position" integer,
    CONSTRAINT chromosomelocation_nn CHECK ((chromosomelocation IS NOT NULL)),
    CONSTRAINT position_nn CHECK (("position" IS NOT NULL))
);


--
-- Name: TABLE sequence_location; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.sequence_location IS 'A location on a sequence';


--
-- Name: COLUMN sequence_location.name; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.sequence_location.name IS 'The short name of this sequence location, arbitrary but often the gene location and nucleotide change';


--
-- Name: COLUMN sequence_location.chromosomelocation; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.sequence_location.chromosomelocation IS 'The partial HGVS representation of the location on the chromosomal sequence';


--
-- Name: COLUMN sequence_location.genelocation; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.sequence_location.genelocation IS 'The partial HGVS representation of the location on the gene sequence';


--
-- Name: COLUMN sequence_location.proteinlocation; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.sequence_location.proteinlocation IS 'The partial HGVS representation of the location on the protein sequence';


--
-- Name: COLUMN sequence_location.genesymbol; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.sequence_location.genesymbol IS 'The HGNC symbol fo the gene this squence location falls in';


--
-- Name: COLUMN sequence_location.dbsnpid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.sequence_location.dbsnpid IS 'The DBSNP identifier (rs#) for this location, optional';


--
-- Name: COLUMN sequence_location."position"; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.sequence_location."position" IS 'The position, or starting position, of this variation on the chromosomal/mitochondrial sequence';


--
-- Name: statistic; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.statistic (
    createdon timestamp without time zone NOT NULL,
    stattype text NOT NULL,
    statvalue numeric NOT NULL
);


--
-- Name: TABLE statistic; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.statistic IS 'A collection of numerical statistics with metadata about this database and other CPIC data';


--
-- Name: term; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.term (
    id integer DEFAULT nextval('cpic.cpic_id'::regclass) NOT NULL,
    category text NOT NULL,
    term text NOT NULL,
    functionaldef text,
    geneticdef text,
    loinc text,
    version integer DEFAULT 1
);


--
-- Name: TABLE term; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.term IS 'Standardized terms for clinical PGx test results';


--
-- Name: COLUMN term.id; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.term.id IS 'A synthetic numerical ID, auto-assigned, primary key';


--
-- Name: COLUMN term.category; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.term.category IS 'Category group this term falls into';


--
-- Name: COLUMN term.term; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.term.term IS 'The term name';


--
-- Name: COLUMN term.functionaldef; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.term.functionaldef IS 'The functional definition of the term';


--
-- Name: COLUMN term.geneticdef; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.term.geneticdef IS 'The genetic definition of the term';


--
-- Name: COLUMN term.loinc; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.term.loinc IS 'The LOINC identifier for the term';




--
-- Data for Name: allele_definition; Type: TABLE DATA; Schema: cpic; Owner: -
--

COPY cpic.allele_definition (id, version, genesymbol, name, pharmvarid, matchesreferencesequence, structuralvariation) FROM stdin;
9000	1	HLA-A	*31:01	\N	f	f
9001	1	HLA-B	*15:02	\N	f	f
9002	1	HLA-B	*57:01	\N	f	f
9003	1	HLA-B	*58:01	\N	f	f
6355249	13	CFTR	F508C	\N	f	f
6355257	13	CFTR	G178E	\N	f	f
777436	185	CYP2B6	*8	PV00746	f	f
6235065	28	CYP2C19	*41	PV02896	f	f
6355263	13	CFTR	G194R(G>C)	\N	f	f
6355265	13	CFTR	G314E	\N	f	f
2091246	129	CYP2D6	*157	PV01947	f	f
778208	185	CYP2D6	*145	PV01437	f	f
6970387	18	SLCO1B1	*56	PV03020	f	f
777592	185	CYP2C19	*34	PV02143	f	f
777716	185	CYP2C9	*25	PV00561	f	f
7721584	6	CYP2C19	*42	PV03036	f	t
777460	185	CYP2B6	*21	PV00759	f	f
777794	185	CYP2C9	*64	PV01419	f	f
778182	185	CYP2D6	*132	PV00687	f	f
1933003	135	CYP2C9	*85	PV01798	f	f
778188	185	CYP2D6	*135	PV00690	f	f
777776	185	CYP2C9	*55	PV00591	f	f
778196	185	CYP2D6	*139	PV00728	f	f
777680	185	CYP2C9	*7	PV00543	f	f
778202	185	CYP2D6	*142	PV01434	f	f
777704	185	CYP2C9	*19	PV00555	f	f
1609527	148	CYP2D6	*148	PV01745	f	f
777732	185	CYP2C9	*33	PV00569	f	f
777492	185	CYP2B6	*37	PV00777	f	f
777766	185	CYP2C9	*50	PV00586	f	f
777494	185	CYP2B6	*38	PV00778	f	f
2091236	129	CYP2D6	*152	PV02155	f	f
777678	185	CYP2C9	*6	PV00542	f	f
6970385	18	SLCO1B1	*55	PV03018	f	f
1406321	155	CYP2C9	*75	PV01742	f	f
777958	185	CYP2D6	*12	PV00437	f	f
2899154	99	CYP2B6	*45	PV02278	f	f
778180	185	CYP2D6	*131	PV00686	f	f
2091238	129	CYP2D6	*153	PV02157	f	f
7977340	1	CYP2D6	*68+*4	\N	f	f
6355213	13	CFTR	A120T	\N	f	f
778184	185	CYP2D6	*133	PV00688	f	f
777450	185	CYP2B6	*15	PV00753	f	f
777440	185	CYP2B6	*10	PV00748	f	f
777452	185	CYP2B6	*17	PV00755	f	f
778206	185	CYP2D6	*144	PV01436	f	f
777454	185	CYP2B6	*18	PV00756	f	f
7094208	8	MT-RNR1	m.930G>A	\N	f	f
2899162	99	CYP2B6	*49	PV02286	f	f
6355217	13	CFTR	A349V	\N	f	f
7977342	1	CYP2D6	*36+*10	\N	f	f
777462	185	CYP2B6	*22	PV00760	f	f
777468	185	CYP2B6	*25	PV00763	f	f
6355215	13	CFTR	A234D	\N	f	f
777470	185	CYP2B6	*26	PV00764	f	f
6355271	13	CFTR	G576A	\N	f	f
777474	185	CYP2B6	*28	PV00766	f	f
6355273	13	CFTR	G970D	\N	f	f
777476	180	CYP2B6	*29	PV00767	f	t
6355279	13	CFTR	G1249R(G>A)	\N	f	f
777478	180	CYP2B6	*30	PV00770	f	t
6355281	13	CFTR	G1249R(G>C)	\N	f	f
6355285	13	CFTR	H939R	\N	f	f
6355231	13	CFTR	D924N	\N	f	f
777333	103	CFTR	E56K	\N	f	f
6355247	13	CFTR	F311L	\N	f	f
777442	185	CYP2B6	*11	PV00749	f	f
6355227	13	CFTR	D192G	\N	f	f
6355241	13	CFTR	E822K	\N	f	f
6355287	13	CFTR	H1375P	\N	f	f
777480	185	CYP2B6	*31	PV00771	f	f
777482	185	CYP2B6	*32	PV00772	f	f
6355289	13	CFTR	I148T	\N	f	f
2899156	99	CYP2B6	*46	PV02280	f	f
2899158	99	CYP2B6	*47	PV02282	f	f
6355293	13	CFTR	I807M	\N	f	f
6355295	13	CFTR	I1027T	\N	f	f
5997308	32	CYP2B6	*50	PV02841	f	f
777578	185	CYP2C19	*26	PV00621	f	f
1103379	167	CYP2D6	*147	PV01805	f	f
6355245	13	CFTR	F311del	\N	f	f
777432	185	CYP2B6	*6	PV00744	f	f
777580	185	CYP2C19	*28	PV00622	f	f
6355297	13	CFTR	I1139V	\N	f	f
777444	185	CYP2B6	*12	PV00750	f	f
6355303	13	CFTR	L320V	\N	f	f
6355305	13	CFTR	L967S	\N	f	f
6355307	13	CFTR	L997F(G>C)	\N	f	f
6355309	13	CFTR	L997F(G>T)	\N	f	f
6355311	13	CFTR	L1480P	\N	f	f
6355313	13	CFTR	M152V	\N	f	f
6355315	13	CFTR	M952I(G>A)	\N	f	f
6355319	13	CFTR	M952I(G>T)	\N	f	f
6355357	13	CFTR	R668C	\N	f	f
777690	185	CYP2C9	*12	PV00548	f	f
777484	185	CYP2B6	*33	PV00848	f	f
6355321	13	CFTR	M952T	\N	f	f
777357	103	CFTR	P67L	\N	f	f
6355325	13	CFTR	Q237E	\N	f	f
6355327	13	CFTR	Q237H	\N	f	f
6355329	13	CFTR	Q359R	\N	f	f
6355331	13	CFTR	Q1291R	\N	f	f
6355335	13	CFTR	R75Q	\N	f	f
6355339	13	CFTR	R117G	\N	f	f
6355343	13	CFTR	R117L	\N	f	f
6355345	13	CFTR	R117P	\N	f	f
6355347	13	CFTR	R170H	\N	f	f
777486	185	CYP2B6	*34	PV00774	f	f
6355351	13	CFTR	R347L	\N	f	f
6355355	13	CFTR	R553Q	\N	f	f
6355359	13	CFTR	R792G	\N	f	f
6355361	13	CFTR	R933G	\N	f	f
777434	185	CYP2B6	*7	PV00745	f	f
777438	185	CYP2B6	*9	PV00747	f	f
777448	185	CYP2B6	*14	PV00752	f	f
777746	185	CYP2C9	*40	PV00576	f	f
777464	185	CYP2B6	*23	PV00761	f	f
2091244	129	CYP2D6	*156	PV01943	f	f
777490	185	CYP2B6	*36	PV00776	f	f
778178	185	CYP2D6	*130	PV00685	f	f
778192	185	CYP2D6	*137	PV00692	f	f
777456	185	CYP2B6	*19	PV00757	f	f
777466	185	CYP2B6	*24	PV00762	f	f
778200	185	CYP2D6	*141	PV02389	f	f
1103381	167	CYP2D6	*149	PV01730	f	f
2677013	107	CYP2D6	*151	PV02194	f	f
7977344	1	CYP2D6	*13+*1	\N	f	f
6970389	18	SLCO1B1	*57	PV03022	f	f
7977347	1	CYP2D6	*13+*2	\N	f	f
6970391	18	SLCO1B1	*58	PV03024	f	f
7977349	1	CYP2D6	*13+*68x2+*4	\N	f	f
7977351	1	CYP2D6	*36x2+*10	\N	f	f
7977354	1	CYP2D6	*68+*2	\N	f	f
778094	185	CYP2D6	*88	PV00505	f	f
5763832	36	CYP2D6	*177	PV02522	f	f
777532	185	CYP2C19	*1	PV00598	f	f
5998158	32	CYP2D6	*178	PV02809	f	f
2784576	103	CYP4F2	*6	PV02225	f	f
778112	185	CYP2D6	*97	PV00514	f	f
779315	178	SLCO1B1	*20	PV01635	f	f
779343	178	SLCO1B1	*34	PV01647	f	f
779347	178	SLCO1B1	*36	PV01648	f	f
778044	185	CYP2D6	*56	PV00480	f	f
779283	178	SLCO1B1	*4	PV01621	f	f
778038	185	CYP2D6	*53	PV00477	f	f
6235063	28	CYP2C19	*40	PV02894	f	f
778086	185	CYP2D6	*84	PV00501	f	f
777758	185	CYP2C9	*46	PV00582	f	f
1002695	169	SLCO1B1	*42	PV01654	f	f
778040	185	CYP2D6	*54	PV00478	f	f
777946	185	CYP2D6	*6	PV00431	f	f
779321	178	SLCO1B1	*23	PV01636	f	f
778048	185	CYP2D6	*58	PV00482	f	f
2784578	103	CYP4F2	*7	PV02227	f	f
778068	185	CYP2D6	*70	PV00492	f	f
5998168	32	CYP2D6	*183	PV02819	f	f
778050	185	CYP2D6	*59	PV00483	f	f
777682	185	CYP2C9	*8	PV00544	f	f
778058	180	CYP2D6	*63	PV00487	f	t
778072	185	CYP2D6	*72	PV00494	f	f
6235320	28	CYP2C9	*86	PV02929	f	f
778052	185	CYP2D6	*60	PV00484	f	f
2677049	107	CYP2D6	*169	PV02163	f	f
778014	185	CYP2D6	*41	PV00465	f	f
778114	185	CYP2D6	*98	PV00515	f	f
778078	185	CYP2D6	*75	PV00497	f	f
2091250	129	CYP2D6	*159	PV01954	f	f
778082	185	CYP2D6	*82	PV00499	f	f
2677051	107	CYP2D6	*170	PV02165	f	f
778096	185	CYP2D6	*89	PV00506	f	f
778090	185	CYP2D6	*86	PV00503	f	f
2677053	107	CYP2D6	*171	PV02189	f	f
3318585	84	CYP4F2	*8	PV02314	f	f
777952	185	CYP2D6	*9	PV00434	f	f
5998170	32	CYP2D6	*184	PV02821	f	f
1002697	169	SLCO1B1	*43	PV01655	f	f
5998172	32	CYP2D6	*185	PV02823	f	f
778016	185	CYP2D6	*42	PV02297	f	f
778024	185	CYP2D6	*46	PV00470	f	f
3318593	84	CYP4F2	*12	PV02322	f	f
3318601	84	CYP4F2	*16	PV02312	f	t
778026	185	CYP2D6	*47	PV00471	f	f
778054	180	CYP2D6	*61	PV00485	f	t
778028	185	CYP2D6	*48	PV00472	f	f
779323	178	SLCO1B1	*24	PV01637	f	f
778032	185	CYP2D6	*50	PV00474	f	f
2091252	129	CYP2D6	*160	PV01958	f	f
778056	185	CYP2D6	*62	PV00486	f	f
1357091	157	SLCO1B1	*48	PV01732	f	t
778060	185	CYP2D6	*64	PV00488	f	f
2091254	129	CYP2D6	*161	PV01963	f	f
778062	185	CYP2D6	*65	PV00489	f	f
777970	185	CYP2D6	*19	PV02196	f	f
778064	180	CYP2D6	*68	PV00490	f	t
4058604	61	CYP4F2	*17	PV02391	f	f
778076	185	CYP2D6	*74	PV00496	f	f
2091256	129	CYP2D6	*162	PV01967	f	f
778066	185	CYP2D6	*69	PV00491	f	f
778030	185	CYP2D6	*49	PV00473	f	f
777948	185	CYP2D6	*7	PV00432	f	f
778018	185	CYP2D6	*43	PV00467	f	f
777950	185	CYP2D6	*8	PV00433	f	f
778020	185	CYP2D6	*44	PV00468	f	f
778070	185	CYP2D6	*71	PV00493	f	f
777978	185	CYP2D6	*23	PV00447	f	f
778080	185	CYP2D6	*81	PV00498	f	f
6235322	28	CYP2C9	*87	PV02931	f	f
778088	185	CYP2D6	*85	PV00502	f	f
778074	185	CYP2D6	*73	PV00495	f	f
779325	178	SLCO1B1	*25	PV01638	f	f
6235324	28	CYP2C9	*88	PV02933	f	f
778186	185	CYP2D6	*134	PV00689	f	f
778108	185	CYP2D6	*95	PV00512	f	f
778084	185	CYP2D6	*83	PV02385	f	f
778204	185	CYP2D6	*143	PV01435	f	f
778092	185	CYP2D6	*87	PV00504	f	f
778240	184	CYP4F2	*2	PV02213	f	f
778022	185	CYP2D6	*45	PV00469	f	f
779297	178	SLCO1B1	*11	PV01628	f	f
3318595	84	CYP4F2	*13	PV02324	f	f
779327	178	SLCO1B1	*26	PV01639	f	f
2677011	107	CYP2D6	*150	PV02524	f	f
778034	185	CYP2D6	*51	PV00475	f	f
5998160	32	CYP2D6	*179	PV02811	f	f
778036	185	CYP2D6	*52	PV00476	f	f
778042	185	CYP2D6	*55	PV00479	f	f
3318599	84	CYP4F2	*15	PV02328	f	f
2091258	129	CYP2D6	*163	PV01969	f	f
3318587	84	CYP4F2	*9	PV02316	f	f
2784572	103	CYP4F2	*4	PV02221	f	f
779080	184	NUDT15	*9	PV01605	f	f
6355367	13	CFTR	R1162L	\N	f	f
2677039	107	CYP2D6	*164	PV02199	f	f
779303	178	SLCO1B1	*14	PV01631	f	f
779331	178	SLCO1B1	*28	PV01641	f	f
2677043	107	CYP2D6	*166	PV02203	f	f
2677045	107	CYP2D6	*167	PV02159	f	f
779305	178	SLCO1B1	*15	PV01632	f	f
3318539	84	CYP2D6	*172	PV02301	f	f
5998162	32	CYP2D6	*180	PV02813	f	f
5175550	46	CYP2D6	*173	PV02498	f	f
5998164	32	CYP2D6	*181	PV02815	f	f
5998166	32	CYP2D6	*182	PV02817	f	f
777988	185	CYP2D6	*28	PV00452	f	f
1002693	169	SLCO1B1	*41	PV01653	f	f
779307	178	SLCO1B1	*16	PV01633	f	f
779335	178	SLCO1B1	*30	PV01643	f	f
779337	178	SLCO1B1	*31	PV01644	f	f
2677047	107	CYP2D6	*168	PV02161	f	f
779339	178	SLCO1B1	*32	PV01645	f	f
5175552	46	CYP2D6	*174	PV02500	f	f
5175554	46	CYP2D6	*175	PV02502	f	f
5409119	42	CYP2D6	*176	PV02519	f	f
3685960	42	RYR1	c.14782A>G	\N	f	f
3685972	42	RYR1	c.14825G>T	\N	f	f
6355395	13	CFTR	T1053I	\N	f	f
6355397	13	CFTR	V232D	\N	f	f
778780	105	G6PD	Taipei, Chinese-3	\N	f	f
778337	103	DPYD	c.295_298delTCAT (*7)	\N	f	f
778242	184	CYP4F2	*3	PV02214	f	f
777552	185	CYP2C19	*11	PV00608	f	f
779333	178	SLCO1B1	*29	PV01642	f	f
777576	185	CYP2C19	*25	PV00620	f	f
1002701	169	SLCO1B1	*45	PV01657	f	f
3685898	42	RYR1	c.14168G>A	\N	f	f
779285	178	SLCO1B1	*5	PV01622	f	f
3685900	42	RYR1	c.14186A>C	\N	f	f
3685902	42	RYR1	c.14197T>G	\N	f	f
3685910	42	RYR1	c.14270G>A	\N	f	f
779232	103	RYR1	c.14387A>G	\N	f	f
3685924	42	RYR1	c.14471T>C	\N	f	f
3685882	42	RYR1	c.13913G>A	\N	f	f
779234	103	RYR1	c.14477C>T	\N	f	f
779236	103	RYR1	c.14497C>T	\N	f	f
778872	103	G6PD	West Virginia	\N	f	f
3685936	42	RYR1	c.14524G>A	\N	f	f
3685938	42	RYR1	c.14539G>C	\N	f	f
3685948	42	RYR1	c.14581C>T	\N	f	f
3685950	42	RYR1	c.14627A>G	\N	f	f
3685952	42	RYR1	c.14639T>C	\N	f	f
3685962	42	RYR1	c.14803G>A	\N	f	f
7096542	16	NAT2	*65	PV02991	f	f
3685974	42	RYR1	c.14879T>A	\N	f	f
777556	185	CYP2C19	*13	PV00610	f	f
778116	185	CYP2D6	*99	PV00516	f	f
777600	185	CYP2C19	*39	PV01528	f	f
779291	178	SLCO1B1	*8	PV01625	f	f
3685954	42	RYR1	c.14678G>A	\N	f	f
6355399	13	CFTR	V562I	\N	f	f
777560	185	CYP2C19	*15	PV00612	f	f
778485	103	DPYD	c.2983G>T (*10)	\N	f	f
3685904	42	RYR1	c.14201G>A	\N	f	f
3685930	42	RYR1	c.14510delA	\N	f	f
3685932	42	RYR1	c.14509C>G	\N	f	f
779240	103	RYR1	c.14545G>A	\N	f	f
3685976	42	RYR1	c.14918C>T	\N	f	f
3685978	42	RYR1	c.14968A>G	\N	f	f
3685916	42	RYR1	c.14424C>A	\N	f	f
3685980	42	RYR1	c.15059G>C	\N	f	f
779279	178	SLCO1B1	*2	PV01619	f	f
779287	178	SLCO1B1	*6	PV01623	f	f
779293	178	SLCO1B1	*9	PV01626	f	f
1002685	169	SLCO1B1	*37	PV01649	f	f
1357093	157	SLCO1B1	*49	PV01734	f	t
7726082	3	TPMT	*45	\N	f	f
6355369	13	CFTR	R1283M	\N	f	f
6355385	13	CFTR	S1159F	\N	f	f
6355377	13	CFTR	S589N	\N	f	f
6355387	13	CFTR	S1159P	\N	f	f
777538	185	CYP2C19	*4	PV00601	f	f
777566	185	CYP2C19	*18	PV00615	f	f
1103377	167	CYP2D6	*146	PV01717	f	f
777568	185	CYP2C19	*19	PV00616	f	f
6355393	13	CFTR	T338I	\N	f	f
777542	185	CYP2C19	*6	PV00603	f	f
777944	180	CYP2D6	*5	PV00430	f	t
778190	185	CYP2D6	*136	PV00691	f	f
777548	185	CYP2C19	*9	PV00606	f	f
2091242	129	CYP2D6	*155	PV01936	f	f
6355401	13	CFTR	V754M	\N	f	f
6355403	13	CFTR	V1293G	\N	f	f
6355405	13	CFTR	W1282R	\N	f	f
7096546	16	NAT2	*67	PV02995	f	f
777564	185	CYP2C19	*17	PV00614	f	f
3685878	42	RYR1	c.13702C>G	\N	f	f
7096550	16	NAT2	*69	PV02999	f	f
6355407	13	CFTR	Y1014C	\N	f	f
6355409	13	CFTR	Y1032C	\N	f	f
777570	185	CYP2C19	*22	PV00617	f	f
778954	103	G6PD	Puerto Limon	\N	f	f
778990	103	G6PD	Santiago de Cuba, Morioka	\N	f	f
777574	185	CYP2C19	*24	PV00619	f	f
777536	185	CYP2C19	*3	PV00600	f	f
777540	185	CYP2C19	*5	PV02131	f	f
777544	185	CYP2C19	*7	PV02134	f	f
779238	103	RYR1	c.14512C>G	\N	f	f
778435	103	DPYD	c.1905C>G	\N	f	f
777598	180	CYP2C19	*37	PV00732	f	t
3685880	42	RYR1	c.13760C>T	\N	f	f
3685906	42	RYR1	c.14209C>T	\N	f	f
3685886	42	RYR1	c.13934G>A	\N	f	f
3685956	42	RYR1	c.14680G>A	\N	f	f
3685964	42	RYR1	c.14813T>C	\N	f	f
3685966	42	RYR1	c.14814C>G	\N	f	f
3685968	42	RYR1	c.14817C>A	\N	f	f
3685970	42	RYR1	c.14818G>A	\N	f	f
3685888	42	RYR1	c.13990T>C	\N	f	f
777534	185	CYP2C19	*2	PV00599	f	f
777572	185	CYP2C19	*23	PV00618	f	f
777594	185	CYP2C19	*35	PV00629	f	f
778453	103	DPYD	c.2279C>T	\N	f	f
6355379	13	CFTR	S737F	\N	f	f
779041	103	IFNL3	rs12979860 reference (C)	\N	t	f
3685908	42	RYR1	c.14210G>A	\N	f	f
779043	103	IFNL3	rs12979860 variant (T)	\N	f	f
3685942	42	RYR1	c.14558C>T	\N	f	f
7096544	16	NAT2	*66	PV02993	f	f
7096548	16	NAT2	*68	PV02997	f	f
1002623	169	SLCO1B1	*1	PV01618	t	f
3685894	42	RYR1	c.14051T>C	\N	f	f
3685944	42	RYR1	c.14567C>G	\N	f	f
779244	103	RYR1	c.14693T>C	\N	f	f
3685918	42	RYR1	c.14449A>T	\N	f	f
3685920	42	RYR1	c.14458G>A	\N	f	f
3685896	42	RYR1	c.14126C>T	\N	f	f
779242	103	RYR1	c.14582G>A	\N	f	f
3685890	42	RYR1	c.13994_13995delTCinsCT	\N	f	f
3685892	42	RYR1	c.14002C>T	\N	f	f
3685922	42	RYR1	c.14458G>T	\N	f	f
777562	185	CYP2C19	*16	PV02139	f	f
3685874	42	RYR1	c.13673G>A	\N	f	f
3685876	42	RYR1	c.13672C>T	\N	f	f
7726084	3	TPMT	*46	\N	f	f
777558	185	CYP2C19	*14	PV00611	f	f
7726086	3	TPMT	*47	\N	f	f
777550	185	CYP2C19	*10	PV00607	f	f
777554	185	CYP2C19	*12	PV00609	f	f
777684	185	CYP2C9	*9	PV00545	f	f
777994	185	CYP2D6	*31	PV00455	f	f
778483	103	DPYD	c.2977C>T	\N	f	f
777770	185	CYP2C9	*52	PV00588	f	f
6235905	28	CYP4F2	*18	PV02945	f	f
777772	185	CYP2C9	*53	PV00589	f	f
777428	185	CYP2B6	*4	PV00742	f	f
777686	185	CYP2C9	*10	PV00546	f	f
6235907	28	CYP4F2	*19	PV02947	f	f
777774	185	CYP2C9	*54	PV00590	f	f
6235909	28	CYP4F2	*20	PV02949	f	f
6235911	28	CYP4F2	*21	PV02951	f	f
778714	103	G6PD	202G>A_376A>G_1264C>G	\N	f	f
777778	185	CYP2C9	*56	PV00592	f	f
777780	185	CYP2C9	*57	PV00593	f	f
6235913	28	CYP4F2	*22	PV02953	f	f
778752	103	G6PD	A	\N	f	f
778712	103	G6PD	A- 202A_376G	\N	f	f
778742	103	G6PD	Acrokorinthos	\N	f	f
779002	103	G6PD	Andalus	\N	f	f
777782	185	CYP2C9	*58	PV00594	f	f
777784	185	CYP2C9	*59	PV00595	f	f
777786	185	CYP2C9	*60	PV00596	f	f
778826	103	G6PD	Asahikawa	\N	f	f
777788	185	CYP2C9	*61	PV00597	f	f
778938	103	G6PD	Beverly Hills, Genova, Iwate, Niigata, Yamaguchi	\N	f	f
777790	185	CYP2C9	*62	PV00851	f	f
777792	185	CYP2C9	*63	PV01418	f	f
777796	185	CYP2C9	*65	PV01420	f	f
779038	103	G6PD	Brighton	\N	f	f
777798	185	CYP2C9	*66	PV01421	f	f
777692	185	CYP2C9	*13	PV00549	f	f
778774	103	G6PD	Gond	\N	f	f
777800	185	CYP2C9	*67	PV01422	f	f
777802	185	CYP2C9	*68	PV01423	f	f
778906	103	G6PD	Ierapetra	\N	f	f
778724	103	G6PD	Lagosanto	\N	f	f
777694	185	CYP2C9	*14	PV00550	f	f
777698	185	CYP2C9	*16	PV00552	f	f
778800	104	G6PD	Mediterranean, Dallas, Panama, Sassari, Cagliari, Birmingham	\N	f	f
778802	103	G6PD	Pedoplis-Ckaro	\N	f	f
778744	103	G6PD	Santa Maria	\N	f	f
3685694	42	RYR1	c.7771C>T	\N	f	f
777804	185	CYP2C9	*69	PV01424	f	f
777806	185	CYP2C9	*70	PV01425	f	f
1406315	155	CYP2C9	*72	PV01736	f	f
1406317	155	CYP2C9	*73	PV01738	f	f
1406319	155	CYP2C9	*74	PV01803	f	f
1932985	135	CYP2C9	*76	PV01780	f	f
6235915	28	CYP4F2	*23	PV02955	f	f
1002689	169	SLCO1B1	*39	PV01651	f	f
1932987	135	CYP2C9	*77	PV01782	f	f
3685726	42	RYR1	c.8518C>T	\N	f	f
777700	185	CYP2C9	*17	PV00553	f	f
1932989	135	CYP2C9	*78	PV01784	f	f
1932991	135	CYP2C9	*79	PV01786	f	f
1932993	135	CYP2C9	*80	PV01788	f	f
777702	185	CYP2C9	*18	PV00554	f	f
777670	185	CYP2C9	*2	PV00538	f	f
6355261	13	CFTR	G194R(G>A)	\N	f	f
6355291	13	CFTR	I175V	\N	f	f
3685758	42	RYR1	c.9758T>C	\N	f	f
3685790	42	RYR1	c.10891G>T	\N	f	f
3685822	42	RYR1	c.11953T>C	\N	f	f
6355317	13	CFTR	M952I(G>C)	\N	f	f
3685856	42	RYR1	c.12553G>A	\N	f	f
777706	185	CYP2C9	*20	PV00556	f	f
777712	185	CYP2C9	*23	PV00559	f	f
777714	185	CYP2C9	*24	PV00560	f	f
777720	185	CYP2C9	*27	PV00563	f	f
777722	185	CYP2C9	*28	PV00564	f	f
777724	185	CYP2C9	*29	PV00565	f	f
777672	185	CYP2C9	*3	PV00539	f	f
777726	185	CYP2C9	*30	PV00566	f	f
777728	185	CYP2C9	*31	PV00567	f	f
777730	185	CYP2C9	*32	PV00568	f	f
777734	185	CYP2C9	*34	PV00570	f	f
1932997	135	CYP2C9	*82	PV01792	f	f
777738	185	CYP2C9	*36	PV00572	f	f
777740	185	CYP2C9	*37	PV00573	f	f
777742	185	CYP2C9	*38	PV00574	f	f
777744	185	CYP2C9	*39	PV00575	f	f
1932999	135	CYP2C9	*83	PV01794	f	f
1933001	135	CYP2C9	*84	PV01796	f	f
777748	185	CYP2C9	*41	PV00577	f	f
777750	185	CYP2C9	*42	PV00578	f	f
777752	185	CYP2C9	*43	PV00579	f	f
777756	185	CYP2C9	*45	PV00581	f	f
777760	185	CYP2C9	*47	PV00583	f	f
777762	185	CYP2C9	*48	PV00584	f	f
777764	185	CYP2C9	*49	PV00585	f	f
777676	185	CYP2C9	*5	PV00541	f	f
777768	185	CYP2C9	*51	PV00587	f	f
777472	185	CYP2B6	*27	PV00765	f	f
2899142	99	CYP2B6	*39	PV02266	f	f
2899146	99	CYP2B6	*41	PV02270	f	f
2899148	99	CYP2B6	*42	PV02272	f	f
2899150	99	CYP2B6	*43	PV02274	f	f
2899152	99	CYP2B6	*44	PV02276	f	f
777430	185	CYP2B6	*5	PV00743	f	f
777530	185	CYP2C19	*38	PV02145	t	f
777936	185	CYP2D6	*1	PV00426	t	f
777954	185	CYP2D6	*10	PV00435	f	f
778118	185	CYP2D6	*100	PV00517	f	f
778120	185	CYP2D6	*101	PV00518	f	f
778122	185	CYP2D6	*102	PV00519	f	f
778124	185	CYP2D6	*103	PV00520	f	f
778126	185	CYP2D6	*104	PV00521	f	f
778128	185	CYP2D6	*105	PV00522	f	f
778130	185	CYP2D6	*106	PV00523	f	f
778132	185	CYP2D6	*107	PV00524	f	f
778136	185	CYP2D6	*109	PV00526	f	f
777956	185	CYP2D6	*11	PV00436	f	f
778138	185	CYP2D6	*110	PV00527	f	f
778140	185	CYP2D6	*111	PV00528	f	f
778142	185	CYP2D6	*112	PV00529	f	f
778144	185	CYP2D6	*113	PV00530	f	f
777962	185	CYP2D6	*14	PV00439	f	f
777964	185	CYP2D6	*15	PV00440	f	f
777966	185	CYP2D6	*17	PV00441	f	f
777968	185	CYP2D6	*18	PV01591	f	f
777938	185	CYP2D6	*2	PV00427	f	f
777972	185	CYP2D6	*20	PV01749	f	f
777974	185	CYP2D6	*21	PV02825	f	f
777976	185	CYP2D6	*22	PV00446	f	f
777980	185	CYP2D6	*24	PV00448	f	f
777982	185	CYP2D6	*25	PV00449	f	f
777984	185	CYP2D6	*26	PV00450	f	f
777986	185	CYP2D6	*27	PV00451	f	f
777990	185	CYP2D6	*29	PV00453	f	f
777940	185	CYP2D6	*3	PV00428	f	f
777992	185	CYP2D6	*30	PV00454	f	f
777996	185	CYP2D6	*32	PV00456	f	f
777998	185	CYP2D6	*33	PV00457	f	f
778000	185	CYP2D6	*34	PV00458	f	f
778002	185	CYP2D6	*35	PV00459	f	f
778004	185	CYP2D6	*36	PV02379	f	f
778006	185	CYP2D6	*37	PV00461	f	f
778008	185	CYP2D6	*38	PV01592	f	f
778010	185	CYP2D6	*39	PV00463	f	f
777942	185	CYP2D6	*4	PV00429	f	f
778012	185	CYP2D6	*40	PV00464	f	f
7219570	14	NAT2	*70	PV03001	f	f
7219572	14	NAT2	*71	PV03003	f	f
7219574	14	NAT2	*72	PV03005	f	f
7219576	14	NAT2	*73	PV03007	f	f
7219578	14	NAT2	*74	PV03011	f	f
7219580	14	NAT2	*75	PV03009	f	f
6237969	28	SLCO1B1	*50	PV02969	f	f
6237971	28	SLCO1B1	*51	PV02971	f	f
6237973	28	SLCO1B1	*52	PV02973	f	f
6237975	28	SLCO1B1	*53	PV02975	f	f
6237977	28	SLCO1B1	*54	PV02977	f	f
6481218	24	NAT2	*31	PV02409	f	f
6481220	24	NAT2	*32	PV02410	f	f
6481228	24	NAT2	*36	PV02414	f	f
6481230	24	NAT2	*37	PV02415	f	f
6481192	24	NAT2	*4	PV02396	f	f
6481256	24	NAT2	*50	PV02428	f	f
6481262	24	NAT2	*53	PV02644	f	f
6481272	24	NAT2	*58	PV02787	f	f
777446	185	CYP2B6	*13	PV00751	f	f
777696	185	CYP2C9	*15	PV00551	f	f
777710	185	CYP2C9	*22	PV00558	f	f
828095	102	MT-RNR1	Reference	\N	t	f
777266	103	CACNA1S	c.3257G>A	\N	f	f
777339	103	CFTR	F1074L	\N	f	f
777379	103	CFTR	S549R(A>C)	\N	f	f
778164	185	CYP2D6	*123	PV00633	f	f
778170	185	CYP2D6	*126	PV00682	f	f
778098	185	CYP2D6	*90	PV00507	f	f
3318597	84	CYP4F2	*14	PV02326	f	f
6481190	24	NAT2	*1	PV02395	t	f
778150	185	CYP2D6	*116	PV00533	f	f
6481240	24	NAT2	*42	PV02420	f	f
6481200	24	NAT2	*10	PV02400	f	f
6481236	24	NAT2	*40	PV02418	f	f
6481208	24	NAT2	*19	PV02404	f	f
778166	185	CYP2D6	*124	PV00634	f	f
3827872	36	MT-RNR1	m.663A>G	\N	f	f
6481210	24	NAT2	*21	PV02405	f	f
3827876	36	MT-RNR1	m.747A>G	\N	f	f
6481264	24	NAT2	*54	PV02771	f	f
6481212	24	NAT2	*27	PV02406	f	f
6481216	24	NAT2	*30	PV02408	f	f
2784574	103	CYP4F2	*5	PV02223	f	f
3827874	36	MT-RNR1	m.669T>C	\N	f	f
6481246	24	NAT2	*45	PV02423	f	f
778152	185	CYP2D6	*117	PV00534	f	f
6481222	24	NAT2	*33	PV02411	f	f
778168	185	CYP2D6	*125	PV00681	f	f
3827880	36	MT-RNR1	m.807A>C	\N	f	f
778172	185	CYP2D6	*127	PV00635	f	f
6481226	24	NAT2	*35	PV02413	f	f
3827882	36	MT-RNR1	m.807A>G	\N	f	f
6481238	24	NAT2	*41	PV02419	f	f
6481244	24	NAT2	*44	PV02422	f	f
3827884	36	MT-RNR1	m.827A>G	\N	f	f
6481254	24	NAT2	*49	PV02427	f	f
6481194	24	NAT2	*5	PV02397	f	f
6481258	24	NAT2	*51	PV02640	f	f
3827878	36	MT-RNR1	m.786G>A	\N	f	f
6481266	24	NAT2	*55	PV02776	f	f
3827886	36	MT-RNR1	m.839A>G	\N	f	f
6481274	24	NAT2	*59	PV02789	f	f
6481196	24	NAT2	*6	PV02398	f	f
6481204	24	NAT2	*15	PV02402	f	f
6481282	24	NAT2	*63	PV02797	f	f
1002691	169	SLCO1B1	*40	PV01652	f	f
6481284	24	NAT2	*64	PV02799	f	f
6481198	24	NAT2	*7	PV02399	f	f
779313	178	SLCO1B1	*19	PV01634	f	f
1002705	169	SLCO1B1	*47	PV01659	f	f
777262	103	CACNA1S	Reference	\N	t	f
779398	103	TPMT	*3B	\N	f	f
3827888	36	MT-RNR1	m.896A>G	\N	f	f
3827892	36	MT-RNR1	m.951G>A	\N	f	f
3827894	36	MT-RNR1	m.960C>del	\N	f	f
3827896	36	MT-RNR1	m.961T>G	\N	f	f
3827898	36	MT-RNR1	m.961T>del	\N	f	f
779392	103	TPMT	*1	\N	t	f
3827900	36	MT-RNR1	m.961T>del+Cn	\N	f	f
3827902	36	MT-RNR1	m.988G>A	\N	f	f
3827904	36	MT-RNR1	m.1095T>C	\N	f	f
3827906	36	MT-RNR1	m.1189T>C	\N	f	f
6481248	24	NAT2	*46	PV02424	f	f
3827908	36	MT-RNR1	m.1243T>C	\N	f	f
3827910	36	MT-RNR1	m.1494C>T	\N	f	f
779400	103	TPMT	*3C	\N	f	f
3827912	36	MT-RNR1	m.1520T>C	\N	f	f
3827914	36	MT-RNR1	m.1537C>T	\N	f	f
779410	103	TPMT	*8	\N	f	f
779402	103	TPMT	*4	\N	f	f
6481232	24	NAT2	*38	PV02416	f	f
3827916	36	MT-RNR1	m.1555A>G	\N	f	f
3827918	36	MT-RNR1	m.1556C>T	\N	f	f
6481206	24	NAT2	*16	PV02403	f	f
6481276	24	NAT2	*60	PV02791	f	f
6481280	24	NAT2	*62	PV02795	f	f
779412	103	TPMT	*9	\N	f	f
779404	103	TPMT	*5	\N	f	f
778176	185	CYP2D6	*129	PV00684	f	f
779406	103	TPMT	*6	\N	f	f
779434	103	TPMT	*20	\N	f	f
779414	103	TPMT	*10	\N	f	f
777674	185	CYP2C9	*4	PV00540	f	f
779416	103	TPMT	*11	\N	f	f
779422	103	TPMT	*14	\N	f	f
779424	103	TPMT	*15	\N	f	f
778156	185	CYP2D6	*119	PV00536	f	f
6481250	24	NAT2	*47	PV02425	f	f
779329	178	SLCO1B1	*27	PV01640	f	f
779426	103	TPMT	*16	\N	f	f
779428	103	TPMT	*17	\N	f	f
779394	103	TPMT	*2	\N	f	f
779430	103	TPMT	*18	\N	f	f
779408	103	TPMT	*7	\N	f	f
778146	185	CYP2D6	*114	PV00531	f	f
778148	185	CYP2D6	*115	PV00532	f	f
778162	185	CYP2D6	*122	PV00632	f	f
779418	103	TPMT	*12	\N	f	f
6481268	24	NAT2	*56	PV02783	f	f
779436	103	TPMT	*21	\N	f	f
779438	103	TPMT	*22	\N	f	f
779440	103	TPMT	*23	\N	f	f
779442	103	TPMT	*24	\N	f	f
779444	103	TPMT	*25	\N	f	f
777458	185	CYP2B6	*20	PV00758	f	f
777488	185	CYP2B6	*35	PV00775	f	f
777546	185	CYP2C19	*8	PV02136	f	f
777688	185	CYP2C9	*11	PV00547	f	f
779341	178	SLCO1B1	*33	PV01646	f	f
779396	103	TPMT	*3A	\N	f	f
779420	103	TPMT	*13	\N	f	f
779432	103	TPMT	*19	\N	f	f
778218	185	CYP3A5	*1	PV01323	t	f
778222	185	CYP3A5	*3	PV01325	f	f
778230	185	CYP3A5	*7	PV01329	f	f
778232	185	CYP3A5	*8	PV01330	f	f
778234	185	CYP3A5	*9	PV01331	f	f
779064	184	NUDT15	*1	PV01597	t	f
779082	184	NUDT15	*10	PV01606	f	f
779084	184	NUDT15	*11	PV01607	f	f
779086	184	NUDT15	*12	PV01608	f	f
779088	184	NUDT15	*13	PV01609	f	f
779090	184	NUDT15	*14	PV01610	f	f
779092	184	NUDT15	*15	PV01611	f	f
779094	184	NUDT15	*16	PV01612	f	f
779096	184	NUDT15	*17	PV01613	f	f
779098	184	NUDT15	*18	PV01614	f	f
779100	184	NUDT15	*19	PV01615	f	f
779102	184	NUDT15	*20	PV01616	f	f
5881976	34	NUDT15	*21	PV02804	f	f
779068	184	NUDT15	*3	PV01599	f	f
779070	184	NUDT15	*4	PV01600	f	f
779072	184	NUDT15	*5	PV01601	f	f
779074	184	NUDT15	*6	PV01602	f	f
779076	184	NUDT15	*7	PV01603	f	f
779078	184	NUDT15	*8	PV01604	f	f
1002699	169	SLCO1B1	*44	PV01656	f	f
779446	103	TPMT	*26	\N	f	f
779448	103	TPMT	*27	\N	f	f
779450	103	TPMT	*28	\N	f	f
779452	103	TPMT	*29	\N	f	f
779454	103	TPMT	*30	\N	f	f
779456	103	TPMT	*31	\N	f	f
779458	103	TPMT	*32	\N	f	f
779460	103	TPMT	*33	\N	f	f
779462	103	TPMT	*34	\N	f	f
779464	103	TPMT	*35	\N	f	f
779466	103	TPMT	*36	\N	f	f
779468	103	TPMT	*37	\N	f	f
779470	103	TPMT	*38	\N	f	f
779472	103	TPMT	*39	\N	f	f
779474	103	TPMT	*40	\N	f	f
779476	103	TPMT	*41	\N	f	f
1508724	84	ABCG2	rs2231142 reference (G)	\N	t	f
779478	103	TPMT	*42	\N	f	f
779480	103	TPMT	*43	\N	f	f
779482	103	TPMT	*44	\N	f	f
779488	103	UGT1A1	*1	\N	t	f
779160	103	RYR1	c.742G>A	\N	f	f
3685398	42	RYR1	c.1144C>A	\N	f	f
3685428	42	RYR1	c.1565A>G	\N	f	f
3685458	42	RYR1	c.2537C>T	\N	f	f
3685488	42	RYR1	c.4024A>G	\N	f	f
3685520	42	RYR1	c.5440A>G	\N	f	f
3685550	42	RYR1	c.6488G>T	\N	f	f
779490	103	UGT1A1	*6	\N	f	f
779492	103	UGT1A1	*27	\N	f	f
779494	103	UGT1A1	*28	\N	f	f
779496	103	UGT1A1	*36	\N	f	f
779498	103	UGT1A1	*37	\N	f	f
779500	103	UGT1A1	*80	\N	f	f
3685580	42	RYR1	c.6743G>A	\N	f	f
779502	103	UGT1A1	*80+*28	\N	f	f
779202	103	RYR1	c.7063C>T	\N	f	f
779206	103	RYR1	c.7282G>A	\N	f	f
779504	103	UGT1A1	*80+*37	\N	f	f
779507	103	VKORC1	rs9923231 reference (C)	\N	t	f
779509	103	VKORC1	rs9923231 variant (T)	\N	f	f
3685646	42	RYR1	c.7292A>T	\N	f	f
779220	103	RYR1	c.7373G>A	\N	f	f
3685704	42	RYR1	c.7879G>C	\N	f	f
3685734	42	RYR1	c.8654C>G	\N	f	f
3685764	42	RYR1	c.9850T>A	\N	f	f
3685794	42	RYR1	c.11120G>T	\N	f	f
3685824	42	RYR1	c.11958C>G	\N	f	f
3685854	42	RYR1	c.12533G>T	\N	f	f
3685884	42	RYR1	c.13918A>G	\N	f	f
3685914	42	RYR1	c.14422_14423delinsAA	\N	f	f
3685334	42	RYR1	c.418G>A	\N	f	f
778228	185	CYP3A5	*6	PV01328	f	f
3685332	42	RYR1	c.251C>T	\N	f	f
3685336	42	RYR1	c.455C>A	\N	f	f
3685338	42	RYR1	c.463C>A	\N	f	f
3318589	84	CYP4F2	*10	PV02318	f	f
3685340	42	RYR1	c.467G>A	\N	f	f
3685342	42	RYR1	c.479A>G	\N	f	f
779154	103	RYR1	c.487C>T	\N	f	f
779156	103	RYR1	c.488G>T	\N	f	f
3685348	42	RYR1	c.488G>A	\N	f	f
3685350	42	RYR1	c.493G>A	\N	f	f
3685352	42	RYR1	c.496G>A	\N	f	f
3685354	42	RYR1	c.497A>G	\N	f	f
3685356	42	RYR1	c.526G>A	\N	f	f
3685358	42	RYR1	c.528G>T	\N	f	f
3685360	42	RYR1	c.529C>T	\N	f	f
3685362	42	RYR1	c.533A>G	\N	f	f
3685364	42	RYR1	c.533A>C	\N	f	f
3685368	42	RYR1	c.641C>T	\N	f	f
3685370	42	RYR1	c.652G>A	\N	f	f
3685372	42	RYR1	c.677T>A	\N	f	f
779190	103	RYR1	c.6502G>A	\N	f	f
3685374	42	RYR1	c.680A>T	\N	f	f
779158	103	RYR1	c.742G>C	\N	f	f
3685380	42	RYR1	c.946C>T	\N	f	f
3685382	42	RYR1	c.947G>T	\N	f	f
779162	103	RYR1	c.982C>T	\N	f	f
3685386	42	RYR1	c.992_994dup	\N	f	f
779164	103	RYR1	c.1021G>A	\N	f	f
779166	103	RYR1	c.1021G>C	\N	f	f
3685392	42	RYR1	c.1024G>A	\N	f	f
3685394	42	RYR1	c.1100G>A	\N	f	f
3685396	42	RYR1	c.1100G>T	\N	f	f
779168	103	RYR1	c.1201C>T	\N	f	f
3685402	42	RYR1	c.1201C>A	\N	f	f
3685404	42	RYR1	c.1201C>G	\N	f	f
3685406	42	RYR1	c.1202G>T	\N	f	f
3685408	42	RYR1	c.1202G>A	\N	f	f
779170	103	RYR1	c.1209C>G	\N	f	f
3685412	42	RYR1	c.1411C>T	\N	f	f
3685414	42	RYR1	c.1422G>T	\N	f	f
3685416	42	RYR1	c.1453A>G	\N	f	f
3685418	42	RYR1	c.1459C>G	\N	f	f
3685420	42	RYR1	c.1460T>C	\N	f	f
3685422	42	RYR1	c.1475G>A	\N	f	f
3685424	42	RYR1	c.1553T>C	\N	f	f
779172	103	RYR1	c.1565A>C	\N	f	f
779174	103	RYR1	c.1589G>A	\N	f	f
779176	103	RYR1	c.1597C>T	\N	f	f
3685434	42	RYR1	c.1597C>A	\N	f	f
779178	103	RYR1	c.1598G>A	\N	f	f
3685438	42	RYR1	c.1615T>C	\N	f	f
3685440	42	RYR1	c.1615T>G	\N	f	f
3685442	42	RYR1	c.1630G>T	\N	f	f
779180	103	RYR1	c.1654C>T	\N	f	f
3685446	42	RYR1	c.1834G>C	\N	f	f
779182	103	RYR1	c.1840C>T	\N	f	f
779184	103	RYR1	c.1841G>T	\N	f	f
3685452	42	RYR1	c.2050G>C	\N	f	f
3685454	42	RYR1	c.2122G>A	\N	f	f
3685456	42	RYR1	c.2447C>T	\N	f	f
3685460	42	RYR1	c.2654G>A	\N	f	f
3685462	42	RYR1	c.2797G>A	\N	f	f
3685464	42	RYR1	c.2924G>A	\N	f	f
3685466	42	RYR1	c.2996G>A	\N	f	f
3685468	42	RYR1	c.3095G>A	\N	f	f
3685470	42	RYR1	c.3127C>T	\N	f	f
3685472	42	RYR1	c.3166G>C	\N	f	f
3685474	42	RYR1	c.3166G>A	\N	f	f
3685476	42	RYR1	c.3172G>A	\N	f	f
3685478	42	RYR1	c.3224G>A	\N	f	f
3685480	42	RYR1	c.3418C>T	\N	f	f
3685482	42	RYR1	c.3527C>T	\N	f	f
3685484	42	RYR1	c.3656A>C	\N	f	f
3685486	42	RYR1	c.3667G>A	\N	f	f
3685490	42	RYR1	c.4178A>G	\N	f	f
3685492	42	RYR1	c.4400A>G	\N	f	f
3685494	42	RYR1	c.4711A>G	\N	f	f
3685496	42	RYR1	c.4747C>T	\N	f	f
3685498	42	RYR1	c.4763C>T	\N	f	f
3685500	42	RYR1	c.4775C>T	\N	f	f
3685502	42	RYR1	c.5024T>C	\N	f	f
3685504	42	RYR1	c.5033A>G	\N	f	f
3685506	42	RYR1	c.5036G>A	\N	f	f
3685508	42	RYR1	c.5132A>G	\N	f	f
3685510	42	RYR1	c.5183C>T	\N	f	f
3685512	42	RYR1	c.5186T>G	\N	f	f
3685514	42	RYR1	c.5317C>T	\N	f	f
3685516	42	RYR1	c.5341T>C	\N	f	f
3685518	42	RYR1	c.5360C>T	\N	f	f
3685522	42	RYR1	c.5441T>A	\N	f	f
3685524	42	RYR1	c.5890C>T	\N	f	f
3685526	42	RYR1	c.6037A>C	\N	f	f
3685528	42	RYR1	c.6178G>T	\N	f	f
3685530	42	RYR1	c.6302T>A	\N	f	f
3685532	42	RYR1	c.6304G>C	\N	f	f
3685534	42	RYR1	c.6349G>C	\N	f	f
3685536	42	RYR1	c.6377G>A	\N	f	f
3685538	42	RYR1	c.6387C>G	\N	f	f
3685540	42	RYR1	c.6388G>A	\N	f	f
3685542	42	RYR1	c.6478G>A	\N	f	f
779186	103	RYR1	c.6487C>T	\N	f	f
779188	103	RYR1	c.6488G>A	\N	f	f
3685548	42	RYR1	c.6488G>C	\N	f	f
3685554	42	RYR1	c.6544A>T	\N	f	f
3685556	42	RYR1	c.6548G>A	\N	f	f
3685558	42	RYR1	c.6599C>T	\N	f	f
3685982	42	RYR1	c.15060G>C	\N	f	f
3685984	42	RYR1	c.14364+1G>T	\N	f	f
778104	185	CYP2D6	*93	PV00510	f	f
778238	184	CYP4F2	*1	PV02212	t	f
3318591	84	CYP4F2	*11	PV02320	f	f
779148	103	RYR1	Reference	\N	t	f
3685308	42	RYR1	c.38T>G	\N	f	f
3685310	42	RYR1	c.51_53del	\N	f	f
3685312	42	RYR1	c.97A>G	\N	f	f
779150	103	RYR1	c.103T>C	\N	f	f
3685316	42	RYR1	c.119G>C	\N	f	f
3685324	42	RYR1	c.178G>A	\N	f	f
3685326	42	RYR1	c.178G>T	\N	f	f
3685328	42	RYR1	c.190T>C	\N	f	f
3685330	42	RYR1	c.212C>A	\N	f	f
3685322	42	RYR1	c.152C>A	\N	f	f
779152	103	RYR1	c.130C>T	\N	f	f
3685320	42	RYR1	c.131G>A	\N	f	f
778459	103	DPYD	c.2482G>A	\N	f	f
778491	103	DPYD	c.3067C>A	\N	f	f
3685570	42	RYR1	c.6640G>A	\N	f	f
3685586	42	RYR1	c.6847A>C	\N	f	f
3685588	42	RYR1	c.6961A>G	\N	f	f
779196	103	RYR1	c.7007G>A	\N	f	f
2899144	99	CYP2B6	*40	PV02268	f	f
2899160	99	CYP2B6	*48	PV02284	f	f
777586	185	CYP2C19	*31	PV00625	f	f
778473	103	DPYD	c.2872A>G	\N	f	f
3685572	42	RYR1	c.6671G>A	\N	f	f
3685574	42	RYR1	c.6670C>T	\N	f	f
777736	185	CYP2C9	*35	PV00571	f	f
777754	185	CYP2C9	*44	PV00580	f	f
778421	103	DPYD	c.1682G>T	\N	f	f
778158	185	CYP2D6	*120	PV00630	f	f
2091248	129	CYP2D6	*158	PV01951	f	f
2677041	107	CYP2D6	*165	PV02201	f	f
778437	103	DPYD	c.1905+1G>A (*2A)	\N	f	f
778445	103	DPYD	c.2161G>A	\N	f	f
777596	180	CYP2C19	*36	PV00730	f	t
777960	180	CYP2D6	*13	PV00438	f	t
3685366	42	RYR1	c.625G>A	\N	f	f
778461	103	DPYD	c.2582A>G	\N	f	f
778194	185	CYP2D6	*138	PV00722	f	f
778333	103	DPYD	c.62G>A	\N	f	f
778335	103	DPYD	c.85T>C (*9A)	\N	f	f
778339	103	DPYD	c.313G>A	\N	f	f
778341	103	DPYD	c.343A>G	\N	f	f
777808	185	CYP2C9	*71	PV01444	f	f
1932995	135	CYP2C9	*81	PV01790	f	f
778134	185	CYP2D6	*108	PV00525	f	f
778351	103	DPYD	c.557A>G	\N	f	f
778353	103	DPYD	c.601A>C	\N	f	f
778198	185	CYP2D6	*140	PV01361	f	f
778355	103	DPYD	c.632A>G	\N	f	f
2091240	129	CYP2D6	*154	PV01934	f	f
778407	103	DPYD	c.1519G>A	\N	f	f
778357	103	DPYD	c.703C>T (*8)	\N	f	f
778367	103	DPYD	c.967G>A	\N	f	f
778369	103	DPYD	c.1003G>T (*11)	\N	f	f
778371	103	DPYD	c.1024G>A	\N	f	f
778154	185	CYP2D6	*118	PV00535	f	f
778373	103	DPYD	c.1057C>T	\N	f	f
778343	103	DPYD	c.451A>G	\N	f	f
778375	103	DPYD	c.1108A>G	\N	f	f
778379	103	DPYD	c.1156G>T (*12)	\N	f	f
778381	103	DPYD	c.1180C>T	\N	f	f
778383	103	DPYD	c.1181G>T	\N	f	f
778385	103	DPYD	c.1218G>A	\N	f	f
778327	103	DPYD	Reference	\N	t	f
778387	103	DPYD	c.1260T>A	\N	f	f
778393	103	DPYD	c.1314T>G	\N	f	f
778395	103	DPYD	c.1349C>T	\N	f	f
778397	103	DPYD	c.1358C>G	\N	f	f
778399	103	DPYD	c.1371C>T	\N	f	f
778345	103	DPYD	c.496A>G	\N	f	f
778401	103	DPYD	c.1403C>A	\N	f	f
778409	103	DPYD	c.1543G>A	\N	f	f
778411	103	DPYD	c.1577C>G	\N	f	f
778413	103	DPYD	c.1601G>A (*4)	\N	f	f
778415	103	DPYD	c.1615G>A	\N	f	f
778417	103	DPYD	c.1627A>G (*5)	\N	f	f
778419	103	DPYD	c.1679T>G (*13)	\N	f	f
778329	103	DPYD	c.46C>G	\N	f	f
778423	103	DPYD	c.1774C>T	\N	f	f
778425	103	DPYD	c.1775G>A	\N	f	f
778427	103	DPYD	c.1777G>A	\N	f	f
778429	103	DPYD	c.1796T>C	\N	f	f
778431	103	DPYD	c.1896T>C	\N	f	f
778433	103	DPYD	c.1898delC (*3)	\N	f	f
778447	103	DPYD	c.2186C>T	\N	f	f
778449	103	DPYD	c.2194G>A (*6)	\N	f	f
778451	103	DPYD	c.2195T>G	\N	f	f
3942827	35	DPYD	c.1129-5923C>G	\N	f	f
778455	103	DPYD	c.2303C>A	\N	f	f
778463	103	DPYD	c.2623A>C	\N	f	f
778359	103	DPYD	c.775A>G	\N	f	f
778465	103	DPYD	c.2639G>T	\N	f	f
778467	103	DPYD	c.2656C>T	\N	f	f
778403	103	DPYD	c.1475C>T	\N	f	f
778457	103	DPYD	c.2336C>A	\N	f	f
778469	103	DPYD	c.2657G>A (*9B)	\N	f	f
778361	103	DPYD	c.868A>G	\N	f	f
778389	103	DPYD	c.1278G>T	\N	f	f
778471	103	DPYD	c.2846A>T	\N	f	f
778475	103	DPYD	c.2915A>G	\N	f	f
778377	103	DPYD	c.1129-5923C>G, c.1236G>A (HapB3)	\N	f	f
778477	103	DPYD	c.2921A>T	\N	f	f
778391	103	DPYD	c.1294G>A	\N	f	f
778479	103	DPYD	c.2933A>G	\N	f	f
778481	103	DPYD	c.2978T>G	\N	f	f
3685560	42	RYR1	c.6612C>G	\N	f	f
778487	103	DPYD	c.3049G>A	\N	f	f
3685576	42	RYR1	c.6710G>A	\N	f	f
3685578	42	RYR1	c.6742C>T	\N	f	f
3685582	42	RYR1	c.6757C>T	\N	f	f
3685592	42	RYR1	c.7018T>C	\N	f	f
778489	103	DPYD	c.3061G>C	\N	f	f
779192	103	RYR1	c.6617C>G	\N	f	f
779194	103	RYR1	c.6617C>T	\N	f	f
3685566	42	RYR1	c.6628G>T	\N	f	f
3685568	42	RYR1	c.6635T>A	\N	f	f
777668	185	CYP2C9	*1	PV00537	t	f
3685584	42	RYR1	c.6838G>A	\N	f	f
777708	185	CYP2C9	*21	PV00557	f	f
778347	103	DPYD	c.498G>A	\N	f	f
777718	185	CYP2C9	*26	PV00562	f	f
778331	103	DPYD	c.61C>T	\N	f	f
778363	103	DPYD	c.929T>C	\N	f	f
778405	103	DPYD	c.1484A>G	\N	f	f
778349	103	DPYD	c.525G>A	\N	f	f
778365	103	DPYD	c.934C>T	\N	f	f
777422	185	CYP2B6	*1	PV00738	t	f
777424	185	CYP2B6	*2	PV00740	f	f
777426	185	CYP2B6	*3	PV00741	f	f
1508726	84	ABCG2	rs2231142 variant (T)	\N	f	f
777264	103	CACNA1S	c.520C>T	\N	f	f
777315	103	CFTR	711+3A->G	\N	f	f
777309	103	CFTR	2789+5G->A	\N	f	f
777311	103	CFTR	3272-26A->G	\N	f	f
777313	103	CFTR	3849+10kbC->T	\N	f	f
777319	103	CFTR	A455E	\N	f	f
777317	103	CFTR	A1067T	\N	f	f
777321	103	CFTR	D110E	\N	f	f
777323	103	CFTR	D110H	\N	f	f
777329	103	CFTR	D579G	\N	f	f
777325	103	CFTR	D1152H	\N	f	f
777327	103	CFTR	D1270N	\N	f	f
777331	103	CFTR	E193K	\N	f	f
777335	103	CFTR	E831X	\N	f	f
777337	103	CFTR	F1052V	\N	f	f
777347	103	CFTR	G178R	\N	f	f
777349	103	CFTR	G551D	\N	f	f
777351	103	CFTR	G551S	\N	f	f
777341	103	CFTR	G1069R	\N	f	f
777343	103	CFTR	G1244E	\N	f	f
777345	103	CFTR	G1349D	\N	f	f
777353	103	CFTR	K1060T	\N	f	f
777355	103	CFTR	L206W	\N	f	f
777371	103	CFTR	R74W	\N	f	f
777363	103	CFTR	R117C	\N	f	f
777365	103	CFTR	R117H	\N	f	f
777367	103	CFTR	R347H	\N	f	f
777369	103	CFTR	R352Q	\N	f	f
777359	103	CFTR	R1070Q	\N	f	f
777361	103	CFTR	R1070W	\N	f	f
777377	103	CFTR	S549N	\N	f	f
777381	103	CFTR	S549R(T>G)	\N	f	f
777383	103	CFTR	S945L	\N	f	f
777385	103	CFTR	S977F	\N	f	f
777373	103	CFTR	S1251N	\N	f	f
777375	103	CFTR	S1255P	\N	f	f
777582	185	CYP2C19	*29	PV00623	f	f
777584	185	CYP2C19	*30	PV02141	f	f
777588	185	CYP2C19	*32	PV00626	f	f
777590	185	CYP2C19	*33	PV00627	f	f
778160	185	CYP2D6	*121	PV00631	f	f
778174	185	CYP2D6	*128	PV01408	f	f
6481202	24	NAT2	*14	PV02401	f	f
6481214	24	NAT2	*29	PV02407	f	f
6481224	24	NAT2	*34	PV02412	f	f
6481234	24	NAT2	*39	PV02417	f	f
6481242	24	NAT2	*43	PV02421	f	f
6481252	24	NAT2	*48	PV02426	f	f
6481260	24	NAT2	*52	PV02642	f	f
6481270	24	NAT2	*57	PV02785	f	f
6481278	24	NAT2	*61	PV02793	f	f
779295	178	SLCO1B1	*10	PV01627	f	f
778100	185	CYP2D6	*91	PV00508	f	f
778102	185	CYP2D6	*92	PV00509	f	f
778106	185	CYP2D6	*94	PV00511	f	f
778110	185	CYP2D6	*96	PV00513	f	f
777307	103	CFTR	ivacaftor non-responsive CFTR sequence	\N	t	f
6606011	11	CFTR	F508C,S1251N	\N	f	f
778439	103	DPYD	c.1906A>C	\N	f	f
778441	103	DPYD	c.1990G>T	\N	f	f
778443	103	DPYD	c.2021G>A	\N	f	f
778666	104	G6PD	B (reference)	\N	t	f
778748	103	G6PD	A- 680T_376G	\N	f	f
778750	103	G6PD	A- 968C_376G	\N	f	f
778916	103	G6PD	Aachen	\N	f	f
778962	103	G6PD	Abeno	\N	f	f
778950	103	G6PD	Alhambra	\N	f	f
778702	103	G6PD	Amazonia	\N	f	f
779006	103	G6PD	Amiens	\N	f	f
778700	103	G6PD	Amsterdam	\N	f	f
778956	103	G6PD	Anadia	\N	f	f
778746	103	G6PD	Ananindeua	\N	f	f
779036	103	G6PD	Arakawa	\N	f	f
778708	103	G6PD	Asahi	\N	f	f
778686	103	G6PD	Aures	\N	f	f
778836	103	G6PD	Aveiro	\N	f	f
778858	103	G6PD	Bajo Maumere	\N	f	f
778844	103	G6PD	Bangkok	\N	f	f
779008	103	G6PD	Bangkok Noi	\N	f	f
778738	103	G6PD	Bao Loc	\N	f	f
778952	103	G6PD	Bari	\N	f	f
778766	103	G6PD	Belem	\N	f	f
779034	103	G6PD	Buenos Aires	\N	f	f
778762	103	G6PD	Cairo	\N	f	f
778922	103	G6PD	Calvo Mackenna	\N	f	f
779032	103	G6PD	Campinas	\N	f	f
779012	103	G6PD	Canton, Taiwan-Hakka, Gifu-like, Agrigento-like	\N	f	f
778994	103	G6PD	Cassano	\N	f	f
778894	103	G6PD	Chatham	\N	f	f
778794	103	G6PD	Chikugo	\N	f	f
778854	103	G6PD	Chinese-1	\N	f	f
778900	103	G6PD	Chinese-5	\N	f	f
778816	103	G6PD	Cincinnati	\N	f	f
778840	103	G6PD	Cleveland Corum	\N	f	f
778936	103	G6PD	Guadalajara	\N	f	f
778726	103	G6PD	Guangzhou	\N	f	f
778852	103	G6PD	Haikou	\N	f	f
778734	103	G6PD	Hammersmith	\N	f	f
778818	103	G6PD	Harilaou	\N	f	f
778998	103	G6PD	Harima	\N	f	f
778940	103	G6PD	Hartford	\N	f	f
778710	103	G6PD	Hechi	\N	f	f
778996	103	G6PD	Hermoupolis	\N	f	f
778676	103	G6PD	Honiara	\N	f	f
778770	103	G6PD	Ilesha	\N	f	f
778890	103	G6PD	Insuli	\N	f	f
778674	103	G6PD	Gaohe	\N	f	f
778978	103	G6PD	Georgia	\N	f	f
778934	103	G6PD	Iowa, Walter Reed, Springfield	\N	f	f
778908	103	G6PD	Iwatsuki	\N	f	f
778970	103	G6PD	Japan, Shinagawa	\N	f	f
779022	103	G6PD	Kaiping, Anant, Dhon, Sapporo-like, Wosera	\N	f	f
778880	103	G6PD	Kalyan-Kerala, Jamnaga, Rohini	\N	f	f
778688	103	G6PD	Kambos	\N	f	f
779016	103	G6PD	Kamiube, Keelung	\N	f	f
778692	103	G6PD	Kamogawa	\N	f	f
778972	103	G6PD	Kawasaki	\N	f	f
778690	103	G6PD	Kozukata	\N	f	f
778944	103	G6PD	Krakow	\N	f	f
778848	103	G6PD	La Jolla	\N	f	f
778672	103	G6PD	Lages	\N	f	f
779026	103	G6PD	Laibin	\N	f	f
778842	103	G6PD	Lille	\N	f	f
778768	103	G6PD	Liuzhou	\N	f	f
778914	103	G6PD	Loma Linda	\N	f	f
778878	103	G6PD	Ludhiana	\N	f	f
778930	103	G6PD	Lynwood	\N	f	f
778932	103	G6PD	Madrid	\N	f	f
778776	103	G6PD	Mahidol	\N	f	f
778796	103	G6PD	Malaga	\N	f	f
778884	103	G6PD	Manhattan	\N	f	f
778984	103	G6PD	Mediterranean Haplotype	\N	f	f
778696	103	G6PD	Metaponto	\N	f	f
778822	103	G6PD	Mexico City	\N	f	f
778790	103	G6PD	Miaoli	\N	f	f
778814	103	G6PD	Minnesota, Marion, Gastonia, LeJeune	\N	f	f
778902	103	G6PD	Mira d'Aire	\N	f	f
778860	103	G6PD	Mizushima	\N	f	f
778868	103	G6PD	Montalbano	\N	f	f
778920	103	G6PD	Montpellier	\N	f	f
778754	103	G6PD	Mt Sinai	\N	f	f
778974	103	G6PD	Munich	\N	f	f
778718	103	G6PD	Murcia Oristano	\N	f	f
778704	103	G6PD	Musashino	\N	f	f
778716	103	G6PD	Namouru	\N	f	f
778788	103	G6PD	Nankang	\N	f	f
778828	103	G6PD	Nanning	\N	f	f
778784	103	G6PD	Naone	\N	f	f
778882	103	G6PD	Nara	\N	f	f
778948	103	G6PD	Nashville, Anaheim, Portici	\N	f	f
779024	103	G6PD	Neapolis	\N	f	f
779014	103	G6PD	Nice	\N	f	f
778808	103	G6PD	Nilgiri	\N	f	f
778668	103	G6PD	No name	\N	f	f
778824	103	G6PD	North Dallas	\N	f	f
778926	103	G6PD	Olomouc	\N	f	f
778876	103	G6PD	Omiya	\N	f	f
778684	103	G6PD	Orissa	\N	f	f
778866	103	G6PD	Osaka	\N	f	f
778694	103	G6PD	Palestrina	\N	f	f
778862	103	G6PD	Papua	\N	f	f
778904	103	G6PD	Partenope	\N	f	f
778986	103	G6PD	Pawnee	\N	f	f
778864	103	G6PD	Piotrkow	\N	f	f
778778	103	G6PD	Plymouth	\N	f	f
778942	103	G6PD	Praha	\N	f	f
778760	103	G6PD	Quing Yan	\N	f	f
778820	103	G6PD	Radlowo	\N	f	f
778886	103	G6PD	Rehevot	\N	f	f
778682	103	G6PD	Rignano	\N	f	f
778924	103	G6PD	Riley	\N	f	f
778968	103	G6PD	Riverside	\N	f	f
778838	103	G6PD	Roubaix	\N	f	f
778992	103	G6PD	S. Antioco	\N	f	f
778758	103	G6PD	Salerno Pyrgos	\N	f	f
778806	103	G6PD	Santiago	\N	f	f
778736	103	G6PD	Sao Borja	\N	f	f
778856	103	G6PD	Seattle, Lodi, Modena, Ferrara II, Athens-like	\N	f	f
778874	103	G6PD	Seoul	\N	f	f
778910	103	G6PD	Serres	\N	f	f
778772	103	G6PD	Shenzen	\N	f	f
778792	103	G6PD	Shinshu	\N	f	f
778812	103	G6PD	Sibari	\N	f	f
778730	103	G6PD	Sierra Leone	\N	f	f
778670	103	G6PD	Sinnai	\N	f	f
778706	103	G6PD	Songklanagarind	\N	f	f
779028	103	G6PD	Split	\N	f	f
778832	103	G6PD	Stonybrook	\N	f	f
778846	103	G6PD	Sugao	\N	f	f
778982	103	G6PD	Sumare	\N	f	f
778678	103	G6PD	Sunderland	\N	f	f
778980	103	G6PD	Surabaya	\N	f	f
778966	103	G6PD	Suwalki	\N	f	f
778720	103	G6PD	Swansea	\N	f	f
3564276	44	G6PD	Telti, Kobe	\N	f	f
778918	103	G6PD	Tenri	\N	f	f
778976	103	G6PD	Tokyo, Fukushima	\N	f	f
778782	103	G6PD	Toledo	\N	f	f
778928	103	G6PD	Tomah	\N	f	f
778912	103	G6PD	Tondela	\N	f	f
778898	103	G6PD	Torun	\N	f	f
778798	103	G6PD	Tsukui	\N	f	f
778722	103	G6PD	Ube Konan	\N	f	f
779000	103	G6PD	Union,Maewo, Chinese-2, Kalo	\N	f	f
778728	103	G6PD	Urayasu	\N	f	f
778964	103	G6PD	Utrecht	\N	f	f
778764	103	G6PD	Valladolid	\N	f	f
778732	103	G6PD	Vancouver	\N	f	f
778756	103	G6PD	Vanua Lava	\N	f	f
778870	103	G6PD	Viangchan, Jammu	\N	f	f
778892	103	G6PD	Villeurbanne	\N	f	f
778786	103	G6PD	Volendam	\N	f	f
778834	103	G6PD	Wayne	\N	f	f
778850	103	G6PD	Wexham	\N	f	f
778960	103	G6PD	Clinic	\N	f	f
778804	103	G6PD	Coimbra Shunde	\N	f	f
779010	103	G6PD	Cosenza	\N	f	f
778698	103	G6PD	Costanzo	\N	f	f
778958	103	G6PD	Covao do Lobo	\N	f	f
778740	103	G6PD	Crispim	\N	f	f
778810	103	G6PD	Dagua	\N	f	f
778830	103	G6PD	Durham	\N	f	f
778888	103	G6PD	Farroupilha	\N	f	f
779004	103	G6PD	Figuera da Foz	\N	f	f
779018	103	G6PD	Flores	\N	f	f
779030	103	G6PD	Fukaya	\N	f	f
778896	103	G6PD	Fushan	\N	f	f
778680	103	G6PD	Gidra	\N	f	f
3685622	42	RYR1	c.7089C>G	\N	f	f
3685624	42	RYR1	c.7090T>G	\N	f	f
3685626	42	RYR1	c.7097C>G	\N	f	f
3685628	42	RYR1	c.7099G>A	\N	f	f
3685630	42	RYR1	c.7112A>G	\N	f	f
3685632	42	RYR1	c.7123G>A	\N	f	f
3685618	42	RYR1	c.7084G>A	\N	f	f
3685620	42	RYR1	c.7085A>G	\N	f	f
779204	103	RYR1	c.7124G>C	\N	f	f
3685636	42	RYR1	c.7199A>G	\N	f	f
3685638	42	RYR1	c.7210G>A	\N	f	f
3685642	42	RYR1	c.7291G>A	\N	f	f
3685644	42	RYR1	c.7291G>T	\N	f	f
779208	103	RYR1	c.7300G>A	\N	f	f
779210	103	RYR1	c.7304G>A	\N	f	f
3685652	42	RYR1	c.7304G>T	\N	f	f
3685654	42	RYR1	c.7307G>A	\N	f	f
3685656	42	RYR1	c.7310C>T	\N	f	f
3685658	42	RYR1	c.7317G>C	\N	f	f
779212	103	RYR1	c.7354C>T	\N	f	f
3685662	42	RYR1	c.7355G>A	\N	f	f
3685664	42	RYR1	c.7355G>C	\N	f	f
3685666	42	RYR1	c.7358T>C	\N	f	f
779214	103	RYR1	c.7360C>T	\N	f	f
779216	103	RYR1	c.7361G>A	\N	f	f
779218	103	RYR1	c.7372C>T	\N	f	f
3685676	42	RYR1	c.7373G>T	\N	f	f
3685678	42	RYR1	c.7385C>T	\N	f	f
3685680	42	RYR1	c.7487C>T	\N	f	f
779222	103	RYR1	c.7522C>T	\N	f	f
779224	103	RYR1	c.7522C>G	\N	f	f
779226	103	RYR1	c.7523G>A	\N	f	f
3685688	42	RYR1	c.7528T>C	\N	f	f
3685690	42	RYR1	c.7760A>G	\N	f	f
3685692	42	RYR1	c.7771C>G	\N	f	f
3685696	42	RYR1	c.7777C>G	\N	f	f
3685698	42	RYR1	c.7778G>A	\N	f	f
3685700	42	RYR1	c.7787C>T	\N	f	f
3685702	42	RYR1	c.7816T>A	\N	f	f
3685706	42	RYR1	c.7879G>A	\N	f	f
3685708	42	RYR1	c.8005G>A	\N	f	f
3685710	42	RYR1	c.8026C>T	\N	f	f
3685712	42	RYR1	c.8054C>T	\N	f	f
3685714	42	RYR1	c.8188G>C	\N	f	f
3685716	42	RYR1	c.8189A>G	\N	f	f
3685718	42	RYR1	c.8198G>A	\N	f	f
3685720	42	RYR1	c.8290G>A	\N	f	f
3685722	42	RYR1	c.8327C>T	\N	f	f
3685724	42	RYR1	c.8360C>G	\N	f	f
3685728	42	RYR1	c.8527T>C	\N	f	f
3685730	42	RYR1	c.8600T>A	\N	f	f
3685732	42	RYR1	c.8638G>A	\N	f	f
3685736	42	RYR1	c.8729C>T	\N	f	f
3685738	42	RYR1	c.8926C>T	\N	f	f
3685740	42	RYR1	c.9152G>A	\N	f	f
3685742	42	RYR1	c.9268G>A	\N	f	f
779228	103	RYR1	c.9310G>A	\N	f	f
3685746	42	RYR1	c.9356G>A	\N	f	f
3685748	42	RYR1	c.9499C>T	\N	f	f
3685750	42	RYR1	c.9635A>G	\N	f	f
3685752	42	RYR1	c.9649T>C	\N	f	f
3685754	42	RYR1	c.9652G>A	\N	f	f
3685756	42	RYR1	c.9676G>C	\N	f	f
3685760	42	RYR1	c.9797T>C	\N	f	f
3685762	42	RYR1	c.9848G>A	\N	f	f
3685766	42	RYR1	c.9868G>A	\N	f	f
3685768	42	RYR1	c.10042C>T	\N	f	f
3685770	42	RYR1	c.10043G>A	\N	f	f
3685772	42	RYR1	c.10097G>A	\N	f	f
3685774	42	RYR1	c.10100A>G	\N	f	f
3685776	42	RYR1	c.10229C>A	\N	f	f
3685778	42	RYR1	c.10237A>T	\N	f	f
3685780	42	RYR1	c.10252A>G	\N	f	f
3685782	42	RYR1	c.10556C>T	\N	f	f
3685784	42	RYR1	c.10616G>A	\N	f	f
3685786	42	RYR1	c.10747G>C	\N	f	f
3685788	42	RYR1	c.10750G>C	\N	f	f
3685792	42	RYR1	c.11086G>C	\N	f	f
3685796	42	RYR1	c.11126C>T	\N	f	f
3685798	42	RYR1	c.11132C>T	\N	f	f
3685800	42	RYR1	c.11266C>G	\N	f	f
3685802	42	RYR1	c.11315G>A	\N	f	f
3685804	42	RYR1	c.11314C>T	\N	f	f
3685806	42	RYR1	c.11416G>A	\N	f	f
3685808	42	RYR1	c.11518G>A	\N	f	f
3685810	42	RYR1	c.11708G>A	\N	f	f
3685812	42	RYR1	c.11723A>T	\N	f	f
3685814	42	RYR1	c.11748T>G	\N	f	f
3685816	42	RYR1	c.11798A>G	\N	f	f
3685818	42	RYR1	c.11813G>A	\N	f	f
3685820	42	RYR1	c.11947C>T	\N	f	f
779230	103	RYR1	c.11969G>T	\N	f	f
3685828	42	RYR1	c.12028G>A	\N	f	f
3685830	42	RYR1	c.12064A>G	\N	f	f
3685832	42	RYR1	c.12115A>T	\N	f	f
3685834	42	RYR1	c.12121C>T	\N	f	f
3685836	42	RYR1	c.12149C>A	\N	f	f
3685838	42	RYR1	c.12242C>T	\N	f	f
3685840	42	RYR1	c.12310G>C	\N	f	f
3685842	42	RYR1	c.12355A>T	\N	f	f
3685844	42	RYR1	c.12383C>T	\N	f	f
3685846	42	RYR1	c.12398A>G	\N	f	f
3685848	42	RYR1	c.12406C>A	\N	f	f
3685850	42	RYR1	c.12413T>C	\N	f	f
3685852	42	RYR1	c.12532G>A	\N	f	f
3685858	42	RYR1	c.12689T>G	\N	f	f
3685860	42	RYR1	c.12700G>C	\N	f	f
3685862	42	RYR1	c.12700G>T	\N	f	f
3685864	42	RYR1	c.12848A>T	\N	f	f
3685866	42	RYR1	c.12881C>T	\N	f	f
3685868	42	RYR1	c.12884C>T	\N	f	f
3685870	42	RYR1	c.13505A>G	\N	f	f
3685872	42	RYR1	c.13513G>C	\N	f	f
778946	103	G6PD	Wisconsin	\N	f	f
779020	103	G6PD	Yunan	\N	f	f
3685594	42	RYR1	c.7025A>G	\N	f	f
3685596	42	RYR1	c.7032G>C	\N	f	f
3685598	42	RYR1	c.7035C>A	\N	f	f
3685600	42	RYR1	c.7036G>A	\N	f	f
779198	103	RYR1	c.7042_7044delGAG	\N	f	f
3685604	42	RYR1	c.7043A>G	\N	f	f
779200	103	RYR1	c.7048G>A	\N	f	f
3685608	42	RYR1	c.7060G>A	\N	f	f
3685612	42	RYR1	c.7073T>A	\N	f	f
3685614	42	RYR1	c.7076G>A	\N	f	f
3685616	42	RYR1	c.7075C>T	\N	f	f
\.


--
-- Data for Name: allele_frequency; Type: TABLE DATA; Schema: cpic; Owner: -
--

COPY cpic.allele_frequency (alleleid, population, frequency, label, version) FROM stdin;
1508725	8088829	0.926	0.9260	1
1508727	8088829	0.074	0.0740	1
1508725	8088830	0.99	0.9900	1
1508727	8088830	0.01	0.0100	1
1508725	8088831	0.8	0.8000	1
1508727	8088831	0.2	0.2000	1
1508725	8088832	0.9068	0.9068	1
1508727	8088832	0.0932	0.0932	1
1508725	8088833	0.6929	0.6929	1
1508727	8088833	0.3071	0.3071	1
1508725	8088834	0.8964	0.8964	1
1508727	8088834	0.1036	0.1036	1
1508725	8088835	0.7756	0.7756	1
1508727	8088835	0.2244	0.2244	1
1508725	8088836	0.9347	0.9347	1
1508727	8088836	0.0653	0.0653	1
1508725	8088837	0.903	0.9030	1
1508727	8088837	0.097	0.0970	1
1508725	8088838	0.893	0.8930	1
1508727	8088838	0.107	0.1070	1
1508725	8088839	0.798	0.7980	1
1508727	8088839	0.202	0.2020	1
1508725	8088840	0.561	0.5610	1
1508727	8088840	0.439	0.4390	1
1508725	8088841	1	1.0000	1
1508727	8088841	0	0.0	1
1508725	8088842	1	1.0000	1
1508727	8088842	0	0.0	1
1508725	8088843	0.987	0.9870	1
1508727	8088843	0.013	0.0130	1
1508725	8088844	0.982	0.9820	1
1508727	8088844	0.018	0.0180	1
1508725	8088845	1	1.0000	1
1508727	8088845	0	0.0	1
777265	8088846	0.00003267	3.267E-5	1
777267	8088846	\N	\N	1
777265	8088847	\N	\N	1
777267	8088847	0	0.0	1
777265	8088848	0.0001087	1.087E-4	1
777267	8088848	0	0.0	1
777265	8088849	0.00001759	1.759E-5	1
777267	8088849	\N	\N	1
777265	8088850	0	0.0	1
777267	8088850	\N	\N	1
777265	8088851	\N	\N	1
777267	8088851	0	0.0	1
777265	8088852	\N	\N	1
777267	8088852	0	0.0	1
777265	8088853	0.00005783	5.783E-5	1
777267	8088853	\N	\N	1
777265	8088854	\N	\N	1
777267	8088854	0.00002891	2.891E-5	1
777265	8088855	0	0.0	1
777267	8088855	\N	\N	1
777265	8088856	\N	\N	1
777267	8088856	0	0.0	1
777425	8088857	\N	\N	1
777427	8088857	0	0.0	1
777429	8088857	\N	\N	1
777431	8088857	\N	\N	1
777433	8088857	\N	\N	1
777435	8088857	\N	\N	1
777437	8088857	\N	\N	1
777439	8088857	\N	\N	1
777441	8088857	\N	\N	1
777443	8088857	\N	\N	1
777445	8088857	\N	\N	1
777447	8088857	\N	\N	1
777449	8088857	\N	\N	1
777451	8088857	\N	\N	1
777453	8088857	\N	\N	1
777455	8088857	\N	\N	1
777457	8088857	\N	\N	1
777459	8088857	\N	\N	1
777461	8088857	\N	\N	1
777463	8088857	\N	\N	1
777465	8088857	\N	\N	1
777467	8088857	\N	\N	1
777469	8088857	\N	\N	1
777471	8088857	\N	\N	1
777473	8088857	\N	\N	1
777475	8088857	\N	\N	1
777477	8088857	\N	\N	1
777479	8088857	\N	\N	1
777481	8088857	\N	\N	1
777483	8088857	\N	\N	1
777485	8088857	\N	\N	1
777487	8088857	\N	\N	1
777489	8088857	\N	\N	1
777491	8088857	\N	\N	1
777493	8088857	\N	\N	1
777495	8088857	\N	\N	1
777425	8088858	\N	\N	1
777427	8088858	\N	\N	1
777429	8088858	\N	\N	1
777431	8088858	\N	\N	1
777433	8088858	0.35	0.35	1
777435	8088858	\N	\N	1
777437	8088858	\N	\N	1
777439	8088858	\N	\N	1
777441	8088858	\N	\N	1
777443	8088858	\N	\N	1
777445	8088858	\N	\N	1
777447	8088858	\N	\N	1
777449	8088858	\N	\N	1
777451	8088858	\N	\N	1
777453	8088858	\N	\N	1
777455	8088858	0.04	0.04	1
777457	8088858	\N	\N	1
777459	8088858	\N	\N	1
777461	8088858	\N	\N	1
777463	8088858	\N	\N	1
777465	8088858	\N	\N	1
777467	8088858	\N	\N	1
777469	8088858	\N	\N	1
777471	8088858	\N	\N	1
777473	8088858	\N	\N	1
777475	8088858	\N	\N	1
777477	8088858	\N	\N	1
777479	8088858	\N	\N	1
777481	8088858	\N	\N	1
777483	8088858	\N	\N	1
777485	8088858	\N	\N	1
777487	8088858	\N	\N	1
777489	8088858	\N	\N	1
777491	8088858	\N	\N	1
777493	8088858	\N	\N	1
777495	8088858	\N	\N	1
778233	8090178	\N	\N	1
777425	8088859	\N	\N	1
777427	8088859	\N	\N	1
777429	8088859	\N	\N	1
777431	8088859	\N	\N	1
777433	8088859	\N	\N	1
777435	8088859	\N	\N	1
777437	8088859	\N	\N	1
777439	8088859	\N	\N	1
777441	8088859	\N	\N	1
777443	8088859	0.003	0.003	1
777445	8088859	\N	\N	1
777447	8088859	\N	\N	1
777449	8088859	\N	\N	1
777451	8088859	\N	\N	1
777453	8088859	\N	\N	1
777455	8088859	\N	\N	1
777457	8088859	\N	\N	1
777459	8088859	\N	\N	1
777461	8088859	\N	\N	1
777463	8088859	\N	\N	1
777465	8088859	\N	\N	1
777467	8088859	\N	\N	1
777469	8088859	\N	\N	1
777471	8088859	\N	\N	1
777473	8088859	\N	\N	1
777475	8088859	\N	\N	1
777477	8088859	\N	\N	1
777479	8088859	\N	\N	1
777481	8088859	\N	\N	1
777483	8088859	\N	\N	1
777485	8088859	\N	\N	1
777487	8088859	\N	\N	1
777489	8088859	\N	\N	1
777491	8088859	\N	\N	1
777493	8088859	\N	\N	1
777495	8088859	\N	\N	1
777425	8088860	0.043	0.043	1
777427	8088860	0	0.0	1
777429	8088860	0	0.0	1
777431	8088860	0.086	0.086	1
777433	8088860	0.328	0.328	1
777435	8088860	0	0.0	1
777423	8088858	0.61	0.61	2
777423	8088857	1	1.0	2
777437	8088860	0	0.0	1
777439	8088860	0	0.0	1
777441	8088860	\N	\N	1
777443	8088860	\N	\N	1
777445	8088860	\N	\N	1
777447	8088860	\N	\N	1
777449	8088860	\N	\N	1
777451	8088860	\N	\N	1
777453	8088860	0.071	0.071	1
777455	8088860	0.029	0.029	1
777457	8088860	0	0.0	1
777459	8088860	0	0.0	1
777461	8088860	0	0.0	1
777463	8088860	0.011	0.011	1
777465	8088860	\N	\N	1
777467	8088860	\N	\N	1
777469	8088860	\N	\N	1
777471	8088860	\N	\N	1
777473	8088860	\N	\N	1
777475	8088860	\N	\N	1
777477	8088860	\N	\N	1
777479	8088860	\N	\N	1
777481	8088860	\N	\N	1
777483	8088860	\N	\N	1
777485	8088860	\N	\N	1
777487	8088860	\N	\N	1
777489	8088860	\N	\N	1
777491	8088860	\N	\N	1
777493	8088860	\N	\N	1
777495	8088860	\N	\N	1
777425	8088861	0	0.0	1
777427	8088861	\N	\N	1
777429	8088861	0.037	0.037	1
777431	8088861	0	0.0	1
777433	8088861	0.259	0.259	1
777435	8088861	0	0.0	1
777437	8088861	\N	\N	1
777439	8088861	0.167	0.167	1
777441	8088861	\N	\N	1
777443	8088861	\N	\N	1
777445	8088861	\N	\N	1
777447	8088861	\N	\N	1
777449	8088861	\N	\N	1
777451	8088861	\N	\N	1
777453	8088861	\N	\N	1
777455	8088861	0.037	0.037	1
777457	8088861	\N	\N	1
777459	8088861	\N	\N	1
777461	8088861	\N	\N	1
777463	8088861	\N	\N	1
777465	8088861	\N	\N	1
777467	8088861	\N	\N	1
777469	8088861	\N	\N	1
777471	8088861	\N	\N	1
777473	8088861	\N	\N	1
777475	8088861	\N	\N	1
777477	8088861	\N	\N	1
777479	8088861	\N	\N	1
777481	8088861	\N	\N	1
777483	8088861	\N	\N	1
777485	8088861	\N	\N	1
777487	8088861	\N	\N	1
777489	8088861	\N	\N	1
777491	8088861	\N	\N	1
777493	8088861	\N	\N	1
777495	8088861	\N	\N	1
778235	8090178	\N	\N	1
777425	8088862	\N	\N	1
777427	8088862	0.008	0.008	1
777429	8088862	\N	\N	1
777431	8088862	\N	\N	1
777433	8088862	\N	\N	1
777435	8088862	\N	\N	1
777437	8088862	\N	\N	1
777439	8088862	\N	\N	1
777441	8088862	\N	\N	1
777443	8088862	0	0.0	1
777445	8088862	0	0.0	1
777447	8088862	\N	\N	1
777449	8088862	0	0.0	1
777451	8088862	0	0.0	1
777453	8088862	\N	\N	1
777455	8088862	\N	\N	1
777457	8088862	\N	\N	1
777459	8088862	\N	\N	1
777461	8088862	\N	\N	1
777463	8088862	\N	\N	1
777465	8088862	0	0.0	1
777467	8088862	\N	\N	1
777469	8088862	\N	\N	1
777471	8088862	\N	\N	1
777473	8088862	\N	\N	1
777475	8088862	\N	\N	1
777477	8088862	\N	\N	1
777479	8088862	\N	\N	1
777481	8088862	\N	\N	1
777483	8088862	\N	\N	1
777485	8088862	\N	\N	1
777487	8088862	\N	\N	1
777489	8088862	\N	\N	1
777491	8088862	\N	\N	1
777493	8088862	\N	\N	1
777495	8088862	\N	\N	1
777425	8088863	\N	\N	1
777427	8088863	0	0.0	1
777429	8088863	\N	\N	1
777431	8088863	\N	\N	1
777433	8088863	\N	\N	1
777435	8088863	\N	\N	1
777437	8088863	\N	\N	1
777439	8088863	\N	\N	1
777441	8088863	\N	\N	1
777443	8088863	0	0.0	1
777445	8088863	0	0.0	1
777447	8088863	\N	\N	1
777449	8088863	0	0.0	1
777451	8088863	0	0.0	1
777453	8088863	\N	\N	1
777455	8088863	\N	\N	1
777457	8088863	\N	\N	1
777459	8088863	\N	\N	1
777461	8088863	\N	\N	1
777463	8088863	\N	\N	1
777465	8088863	0.005	0.005	1
777467	8088863	\N	\N	1
777469	8088863	\N	\N	1
777471	8088863	\N	\N	1
777473	8088863	\N	\N	1
777475	8088863	\N	\N	1
777477	8088863	\N	\N	1
777479	8088863	\N	\N	1
777481	8088863	\N	\N	1
777483	8088863	\N	\N	1
777485	8088863	\N	\N	1
777487	8088863	\N	\N	1
777489	8088863	\N	\N	1
777491	8088863	\N	\N	1
777493	8088863	\N	\N	1
777495	8088863	\N	\N	1
777425	8088864	\N	\N	1
777427	8088864	0	0.0	1
777429	8088864	\N	\N	1
777431	8088864	\N	\N	1
777433	8088864	\N	\N	1
777435	8088864	\N	\N	1
777437	8088864	\N	\N	1
777439	8088864	\N	\N	1
777441	8088864	\N	\N	1
777443	8088864	0	0.0	1
777445	8088864	0	0.0	1
777447	8088864	\N	\N	1
777449	8088864	0	0.0	1
777451	8088864	0	0.0	1
777453	8088864	\N	\N	1
777455	8088864	\N	\N	1
777457	8088864	\N	\N	1
777459	8088864	\N	\N	1
777461	8088864	\N	\N	1
777463	8088864	\N	\N	1
777465	8088864	0	0.0	1
777467	8088864	\N	\N	1
777469	8088864	\N	\N	1
777471	8088864	\N	\N	1
777473	8088864	\N	\N	1
777475	8088864	\N	\N	1
777477	8088864	\N	\N	1
777479	8088864	\N	\N	1
777481	8088864	\N	\N	1
777483	8088864	\N	\N	1
777485	8088864	\N	\N	1
777487	8088864	\N	\N	1
777489	8088864	\N	\N	1
777491	8088864	\N	\N	1
777493	8088864	\N	\N	1
777495	8088864	\N	\N	1
777423	8088864	1	1.0	2
777423	8088863	0.995	0.995	2
777423	8088861	0.5	0.5	2
777425	8088865	\N	\N	1
777427	8088865	0	0.0	1
777429	8088865	\N	\N	1
777431	8088865	\N	\N	1
777433	8088865	\N	\N	1
777435	8088865	\N	\N	1
777437	8088865	\N	\N	1
777439	8088865	\N	\N	1
777441	8088865	\N	\N	1
777443	8088865	0.006	0.006	1
777445	8088865	0	0.0	1
777447	8088865	\N	\N	1
777449	8088865	0	0.0	1
777451	8088865	0	0.0	1
777453	8088865	\N	\N	1
777455	8088865	\N	\N	1
777457	8088865	\N	\N	1
777459	8088865	\N	\N	1
777461	8088865	\N	\N	1
777463	8088865	\N	\N	1
777465	8088865	0	0.0	1
777467	8088865	\N	\N	1
777469	8088865	\N	\N	1
777471	8088865	\N	\N	1
777473	8088865	\N	\N	1
777475	8088865	\N	\N	1
777477	8088865	\N	\N	1
777479	8088865	\N	\N	1
777481	8088865	\N	\N	1
777483	8088865	\N	\N	1
777485	8088865	\N	\N	1
777487	8088865	\N	\N	1
777489	8088865	\N	\N	1
777491	8088865	\N	\N	1
777493	8088865	\N	\N	1
777495	8088865	\N	\N	1
777425	8088866	\N	\N	1
777427	8088866	0.005	0.005	1
777429	8088866	\N	\N	1
777431	8088866	\N	\N	1
777433	8088866	\N	\N	1
777435	8088866	\N	\N	1
777437	8088866	\N	\N	1
777439	8088866	\N	\N	1
777441	8088866	\N	\N	1
777443	8088866	0	0.0	1
777445	8088866	0	0.0	1
777447	8088866	\N	\N	1
777449	8088866	0	0.0	1
777451	8088866	0	0.0	1
777453	8088866	\N	\N	1
777455	8088866	\N	\N	1
777457	8088866	\N	\N	1
777459	8088866	\N	\N	1
777461	8088866	\N	\N	1
777463	8088866	\N	\N	1
777465	8088866	0	0.0	1
777467	8088866	\N	\N	1
777469	8088866	\N	\N	1
777471	8088866	\N	\N	1
777473	8088866	\N	\N	1
777475	8088866	\N	\N	1
777477	8088866	\N	\N	1
777479	8088866	\N	\N	1
777481	8088866	\N	\N	1
777483	8088866	\N	\N	1
777485	8088866	\N	\N	1
777487	8088866	\N	\N	1
777489	8088866	\N	\N	1
777491	8088866	\N	\N	1
777493	8088866	\N	\N	1
777495	8088866	\N	\N	1
777425	8088867	\N	\N	1
777427	8088867	0.005	0.005	1
777429	8088867	\N	\N	1
777431	8088867	\N	\N	1
777433	8088867	\N	\N	1
777435	8088867	\N	\N	1
777437	8088867	\N	\N	1
777439	8088867	\N	\N	1
777441	8088867	\N	\N	1
777443	8088867	0	0.0	1
777445	8088867	0	0.0	1
777447	8088867	\N	\N	1
777449	8088867	0	0.0	1
777451	8088867	0	0.0	1
777453	8088867	\N	\N	1
777455	8088867	\N	\N	1
777457	8088867	\N	\N	1
777459	8088867	\N	\N	1
777461	8088867	\N	\N	1
777463	8088867	\N	\N	1
777465	8088867	0	0.0	1
777467	8088867	\N	\N	1
777469	8088867	\N	\N	1
777471	8088867	\N	\N	1
777473	8088867	\N	\N	1
777475	8088867	\N	\N	1
777477	8088867	\N	\N	1
777479	8088867	\N	\N	1
777481	8088867	\N	\N	1
777483	8088867	\N	\N	1
777485	8088867	\N	\N	1
777487	8088867	\N	\N	1
777489	8088867	\N	\N	1
777491	8088867	\N	\N	1
777493	8088867	\N	\N	1
777495	8088867	\N	\N	1
777425	8088868	\N	\N	1
777427	8088868	0.002456	0.002456	1
777429	8088868	\N	\N	1
777431	8088868	\N	\N	1
777433	8088868	\N	\N	1
777435	8088868	\N	\N	1
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777535	8089252	0.141	0.1410	1
777537	8089252	\N	\N	1
777539	8089252	\N	\N	1
777541	8089252	\N	\N	1
777543	8089252	\N	\N	1
777545	8089252	\N	\N	1
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777549	8089252	\N	\N	1
777551	8089252	\N	\N	1
777553	8089252	\N	\N	1
777555	8089252	\N	\N	1
777557	8089252	\N	\N	1
777559	8089252	\N	\N	1
777561	8089252	\N	\N	1
777563	8089252	\N	\N	1
777565	8089252	\N	\N	1
777567	8089252	\N	\N	1
777569	8089252	\N	\N	1
777571	8089252	\N	\N	1
777573	8089252	\N	\N	1
777575	8089252	\N	\N	1
777577	8089252	\N	\N	1
777579	8089252	\N	\N	1
777581	8089252	\N	\N	1
777583	8089252	\N	\N	1
777585	8089252	\N	\N	1
777587	8089252	\N	\N	1
777589	8089252	\N	\N	1
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777535	8089253	0.1116	0.1116	1
777537	8089253	\N	\N	1
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777535	8089254	0.1312	0.1312	1
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777543	8089254	\N	\N	1
777545	8089254	\N	\N	1
777547	8089254	\N	\N	1
