NUDT15*11 is assigned uncertain function based on inadequate evidence. An in vitro study expressed NUDT15*11 in HEK293 cells and found that protein expression and thiopurine sensitivity were comparable to cells expressing NUDT15*1 (32094176). Nine out of nine variant effect predictors tested by CPIC staff predict that the NUDT15*11-defining SNV (c.139G>A (p.G47R)) impairs protein function.