NAT2*41 is assigned uncertain function based on inadequate evidence. NAT2*41 is characterized by the core SNV c.578C>T (p.T193M). Published in silico modeling predicts that c.578C>T (p.T193M) impairs protein function based on exposure of hydrophobic residues that may facilitate protein aggregation or targeted degradation (19909761). Similarly, six out of ten variant effect predictors tested by CPIC staff predict that c.578C>T (p.T193M) impairs protein function. There are no in vitro or in vivo functional studies for NAT2*41