removed G85E, N1303K, W1282X, I507del, R347P, R560T, R334W ivacaftor label states"... mutations in the CFTR gene do not meet the threshold of change in CFTR mediated chloride transport of at least 10% of normal over baseline" However, variants are part of the variants recommended by the American College of Medical Genetics (ACMG) Cystic Fibrosis Carrier Screening Working Group that should be tested to determine carrier status as a part of population screening programs PMID 15371902.