-- Data for Name: file_note; Type: TABLE DATA; Schema: cpic; Owner: -
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ALLELE_DEFINITION	CACNA1S	Variant selection based on the CPIC guideline for potent volatile anesthetic agents and succinylcholine and RYR1 and CACNA1S.	0	1
ALLELE_FUNCTION_REFERENCE	CYP2D6	CNV alleles are based on Table 2 'CYP2D6 Identical Gene Duplications/Multiplications' from the PharmVar CYP2D6 structural variation document (https://a.storyblok.com/f/70677/x/d80b535e9c/cyp2d6_structural-variation_v3-2.pdf).	0	1
GENE_CDS	ABCG2	The phenotype is used to store an interpretation of the test result. This is a design decision that may differ among sites.	0	1
GENE_CDS	ABCG2	For this example, a priority result is defined as a genetic test result that results in a change in drug, drug dose, or drug monitoring.	1	1
GENE_CDS	ABCG2	The specific wording of the interpretive text may differ among sites.	2	1
FREQUENCY	MT-RNR1	For full references see "References" tab.	0	1
FREQUENCY	MT-RNR1	aAverage frequencies based on the reported frequencies in one or multiple studies.	1	1
FREQUENCY	MT-RNR1	bBased on the PharmGKB biogeographical groups https://www.pharmgkb.org/page/biogeographicalGroups	2	1
TEST_ALERT	RxNorm:17128	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:17128	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:17128	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:17128	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:1191	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:1191	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:1191	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:1191	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:6878	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:6878	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:10638	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:10638	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
ALLELE_DEFINITION	CFTR	rsID=RefSNP accession ID number (http://www.ncbi.nlm.nih.gov/snp/)	0	1
ALLELE_DEFINITION	CFTR	All variants are annotated to the positive chromosomal strand.	1	1
ALLELE_DEFINITION	CFTR	Class is defined in PMID: 20932301.	2	1
ALLELE_DEFINITION	CFTR	Table includes variants listed as ivacaftor responsive on FDA-approved ivacaftor (Kalydeco) label (see change log for updates).	3	1
ALLELE_DEFINITION	CFTR	The ivacaftor (Kalydeco) label includes the CFTR variants as amino acid changes. Based on information in dbSNP, for four variants, the amino acid change can be coded by >1 nucleotide change at the same genomic position. In these cases the variant was named with the protein change and the nucleotide change in parentheses.	4	1
ALLELE_DEFINITION	CFTR	The ivacaftor label includes F311del. The variant is caused by a 3 bp deletion within a repetitive sequence C TTC TTC TTC T at nucleotide position 1059-1069. This results in a deletion of one of the phenylalanine residues at either position 311, 312 or 313.	5	1
ALLELE_DEFINITION	CFTR	F508C;S1251N includes the following footnote for Table 3 of the FDA-approved ivacaftor label (annotated by ClinPGx 10/05/2023): "Complex/compound mutations where a single allele of the CFTR gene has multiple mutations; these exist independent of the presence of mutations on the other allele."	6	1
ALLELE_FUNCTION_REFERENCE	NAT2	The NAT gene nomenclature committee has curated, annotated, and assigned function to NAT2 star alleles since 1997. In March 2024, NAT2 nomenclature was transferred to PharmVar with some major changes. Most notably, the creation of NAT2*1 as the reference allele in accordance with the reference genome GRCh38. NAT2*4, the former reference allele, is defined by the presence of the SNV c.803G>A. Historically, acetylation function was assigned to NAT2 * alleles as either "rapid" or "slow". Under the CPIC allele function terminology, rapid acetylation alleles are categorized as "Increased Function" and slow acetylation alleles are categorized as "Decreased Function". More information can be found at the NAT gene nomenclature committee website, including legacy allele nomenclature and functional assignments (see links below). Additionally, see the PharmVar NAT2 Read Me document (link below)	0	1
ALLELE_FUNCTION_REFERENCE	NAT2	NAT Gene Nomenclature Committee Homepage, https://nat.mbg.duth.gr/Homepage.htm	1	1
ALLELE_FUNCTION_REFERENCE	NAT2	Legacy NAT2 allele nomenclature and functional assignments, https://nat.mbg.duth.gr/Human_NAT2_alleles.htm	2	1
ALLELE_FUNCTION_REFERENCE	NAT2	PharmVar NAT2 Read Me, https://a.storyblok.com/f/70677/x/047a3728ff/gene-info_nat2_v1-2.pdf.	3	1
GENE_CDS	CACNA1S	The phenotype is used to store an interpretation of the test result. This is a design decision that may differ among sites.	0	1
GENE_CDS	CACNA1S	For this example, a priority result is defined as a genetic test result that results in a change in drug, drug dose, or drug monitoring.	1	1
GENE_CDS	CACNA1S	The specific wording of the interpretive text may differ among sites.	2	1
FREQUENCY	NUDT15	For full references see "References" tab.	0	1
FREQUENCY	NUDT15	Average frequencies based on the reported frequencies in one or multiple studies.	1	1
FREQUENCY	NUDT15	Based on the PharmGKB biogeographical groups https://www.pharmgkb.org/page/biogeographicalGroups	2	1
FREQUENCY	NUDT15	See allele definition table (https://www.pharmgkb.org/page/nudt15RefMaterials) for allele definitions	3	1
FREQUENCY	NUDT15	Because NUDT15*1 is not genotyped directly, all alleles that are negative for a sequence variation are defaulted to a NUDT15*1 assignment. The inferred frequency for NUDT15*1 is calculated as: 1 - (sum of averaged variant allele frequencies).	4	1
TEST_ALERT	RxNorm:6472	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:6472	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:38400	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:38400	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:38400	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:38400	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:6918	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:6918	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:10689	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:10689	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
ALLELE_DEFINITION	CYP2B6	rsID=RefSNP accession ID number (http://www.ncbi.nlm.nih.gov/snp/)	0	1
ALLELE_DEFINITION	CYP2B6	All variants are annotated to the positive chromosomal strand.	1	1
ALLELE_DEFINITION	CYP2B6	See PharmVar website (http://www.pharmvar.org) for comprehensive haplotype definitions of CYP2B6 variant alleles and updated allele information.	2	1
ALLELE_DEFINITION	CYP2B6	An important caveat for all genotyping tests is that the decision to assign an allele a "wild-type" status is based upon a genotyping test that interrogates only the most common and already-proven sites of functional variation. In human DNA, it is always possible that a new, previously undiscovered (and therefore un-interrogated) site of variation may confer loss-of-function in an individual, and thus lead to the rare possibility of a non-functional allele being erroneously called as "wild-type."	3	1
ALLELE_FUNCTION_REFERENCE	RYR1	Variant selection based on an update of the CPIC guideline for potent volatile anesthetic agents and succinylcholine. The guideline update includes the published list of RYR1 variants (supplemental Table S2), which are evaluated by the ClinGen malignant hyperthermia susceptibility (MHS) variant curation expert panel (VCEP) and classified for RYR1-related malignant hyperthermia susceptibility based on specified ACMG/AMP criteria (PMID 35849058). The entries in the column 'Allele Functional Status (Optional)' are from the 'Pathogenicity' column and the entries in the column 'Findings (Optional)' are from the ACMG/AMP Criteria column in Table S2 (PMID 35849058).	0	1
ALLELE_FUNCTION_REFERENCE	RYR1	Variants 1209C>G, 7522C>G, 14387A>G, 14693T>C are not included in the PMID 35849058 and are classified as VUS by the RYR1 VCEP in May 2023.	1	1
ALLELE_FUNCTION_REFERENCE	RYR1	Variant classification was re-evaluated and updated by the RYR1 VCEP in May 2023 for the following variants: c.488G>T, c.1589G>A, c.7522C>T, c.14210G>A, c.14582G>A, c.6612C>G, c.14918C>T, c.5183C>T, c.5132A>G, c.6838G>A	2	1
ALLELE_FUNCTION_REFERENCE	RYR1	Variant classification was re-evaluated and updated by the RYR1 VCEP in Nov 2023 for the following variants: c.6488G>T, c.14627A>G, c.14813T>C	3	1
ALLELE_FUNCTION_REFERENCE	RYR1	Allele Clinical Functional Status is mapped to the classification by the ClinGen malignant hyperthermia susceptibility (MHS) variant curation expert panel PMID: 35849058 as follows:	4	1
ALLELE_FUNCTION_REFERENCE	RYR1	Pathogenic = Malignant Hyperthermia associated	5	1
ALLELE_FUNCTION_REFERENCE	RYR1	Likely Pathogenic = Malignant Hyperthermia associated	6	1
ALLELE_FUNCTION_REFERENCE	RYR1	Variant of uncertain significance = Uncertain function	7	1
ALLELE_FUNCTION_REFERENCE	RYR1	Likely Benign = Normal function	8	1
ALLELE_FUNCTION_REFERENCE	RYR1	Benign = Normal function	9	1
ALLELE_FUNCTION_REFERENCE	RYR1	"Reference" is included in the CPIC RYR1 allele definition table. Allele Clinical Functional Status is assigned Normal function.	10	1
GENE_CDS	CYP2B6	The phenotype is used to store an interpretation of the test result. This is a design decision that may differ among sites.	0	1
GENE_CDS	CYP2B6	For this example, a priority result is defined as a genetic test result that results in a change in drug, drug dose, or drug monitoring.	1	1
GENE_CDS	CYP2B6	The specific wording of the interpretive text may differ among sites.	2	1
GENE_CDS	CYP2B6	Although two CYP2B6 alleles, *4 and *22, are categorized as increased function alleles, the effect of *4 and *22 on CYP2B6 function with respect to efavirenz plasma exposure appears to be modest based on current evidence. However, the phenotype categories of CYP2B6 rapid metabolizer (RM; one normal function allele and one increased function allele) and CYP2B6 ultra-rapid metabolizer (UM; two increased function alleles) were created to allow for the possibility that these may be clinically relevant for CYP2B6 substrates other than efavirenz. As there is no recommendation for altering dosing for CYP2B6 RMs or UMs for efavirenz, the EHR priority is sent to "normal" for these metabolizers.	3	1
FREQUENCY	RYR1	For full references see "References" tab.	0	1
TEST_ALERT	RxNorm:6857	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:6857	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:1256	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:1256	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:7240	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:7240	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:7240	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:7240	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:27392	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:27392	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
ALLELE_DEFINITION	CYP2C19	The variants included in the alleles are based on the PharmVar core alleles (for core allele definitions only, see https://www.pharmvar.org/gene/CYP2C19). In addition, variants that present in the core allele for one star allele but also present in some but not allsuballeles of another star allele are included in the other star allele as ambiguous changes using the IUPAC nucleotide code (https://www.bioinformatics.org/sms/iupac.html), e.g. the *4 consensus allele includes a "Y" being either C or T at the -806C>T position since this variant is part of the *17 core allele but is not part of the *4 core allele at PharmVar since it is not present in all *4 suballeles. These postions are represented in grey in the Comparative Allele ViewEr (CAVE) tool at PharmVar.	0	1
ALLELE_DEFINITION	CYP2C19	PharmVAR releases new alleles based on received submissions, see https://www.pharmvar.org for comprehensive haplotype definitions of CYP2C19 variant alleles, including sub-alleles, and updated allele information.	1	1
ALLELE_DEFINITION	CYP2C19	rsID=RefSNP accession ID number (http://www.ncbi.nlm.nih.gov/snp/)	2	1
ALLELE_DEFINITION	CYP2C19	All variants are annotated to the positive DNA strand.	3	1
ALLELE_DEFINITION	CYP2C19	An important caveat for all genotyping tests is that the decision to assign an allele a wild-type status is based upon a genotyping test that interrogates only the most common and already- proven sites of functional variation. It is always possible that a novel, previously undiscovered (and therefore un-interrogated) site of variation may confer loss-of-function in an individual, and thus lead to the rare possibility of a non-functional allele being erroneously called as wild-type.	4	1
ALLELE_DEFINITION	CYP2C19	The deterimental CYP2C19*4-defining SNP (rs28399504) has been identified to be linked (i.e. on the same chromosome) with *17 (-806C>T; rs12248560) in certain ethnic subpopulations. To distinguish the *4 (no function) and *17 (increased function) alleles, both rs28399504 and rs12248560 needs to be genotyped [PMID: 21358751, PMID: 24012947]). This haplotype is designated CYP2C19*4B [PMID: 21716271, PMID: 21358751].	5	1
ALLELE_DEFINITION	CYP2C19	The SNP c.463G>T (rs374036992) has been identified to occur in linkage with the *17-defining SNP (- 806C>T; rs12248560). To distinguish *17 from this haplotype, c.463G>T needs to be genotyped [PMID: 25141895]. This allele has not been submitted to PharmVar for a star allele designation.	6	1
ALLELE_DEFINITION	CYP2C19	CYP2C19*27 was reassigned to CYP2C19*1.006 with PharmVar Version 4.0 Last Updated May 7 2019	7	1
ALLELE_DEFINITION	CYP2C19	CYP2C19*36 is a full gene deletion and *37 is a partial gene deletion that includes at least exon 1; for details see the PharmVar CYP2C19 GeneFocus (PMID 32602114) and the CYP2C19 Structural Variation document at https://www.pharmvar.org/gene/CYP2C19).	8	1
ALLELE_DEFINITION	CYP2C19	CYP2C19*38 was set as reference allele as this allele matches the human genome CYP2C19 Reference sequence LRG_584 / NG_008384.3. The RefSeq (LRG_584 / NG_008384.3) has 80161A while many of star alleles, including all *1 suballeles have 80161G. Thus, the CYP2C19*1 core allele is defined by one amino acid (I331V), while the *38 core allele definition does not have any amino acid changes.	9	1
GENE_CDS	CYP2C19	The phenotype is used to store an interpretation of the test result. This is a design decision that may differ among sites.	0	1
GENE_CDS	CYP2C19	For this example, a priority result is defined as a genetic test result that results in a change in drug, drug dose, or drug monitoring.	1	1
GENE_CDS	CYP2C19	The specific wording of the interpretive text may differ among sites.	2	1
FREQUENCY	SLCO1B1	For full references see "References" tab.	0	1
FREQUENCY	SLCO1B1	Average frequencies based on the reported frequencies in one or multiple studies.	1	1
FREQUENCY	SLCO1B1	Based on the PharmGKB biogeographical groups https://www.pharmgkb.org/page/biogeographicalGroups	2	1
FREQUENCY	SLCO1B1	See allele definition table (https://www.pharmgkb.org/page/slco1b1RefMaterials) for allele definitions	3	1
FREQUENCY	SLCO1B1	Because SLCO1B1*1 is not genotyped directly, all alleles that are negative for a sequence variation are defaulted to a SLCO1B!*1 assignment. The inferred frequency for SLCO1B1*1 is calculated as: 1 - (sum of averaged variant allele frequencies).	4	1
TEST_ALERT	RxNorm:7531	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:7531	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:194000	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:194000	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:7299	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:7299	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:39786	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:39786	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
ALLELE_DEFINITION	CYP2C9	PharmVAR releases new alleles based on received submissions, see https://www.pharmvar.org for comprehensive haplotype definitions of CYP2C9 variant alleles, including sub-alleles, and updated allele information.	0	1
ALLELE_DEFINITION	CYP2C9	rsID=RefSNP accession ID number (http://www.ncbi.nlm.nih.gov/snp/)	1	1
ALLELE_DEFINITION	CYP2C9	All variants are annotated to the positive DNA strand.	2	1
ALLELE_DEFINITION	CYP2C9	An important caveat for all genotyping tests is that the decision to assign an allele a "wild-type" status is based upon a genotyping test that interrogates only the most common and already-proven sites of functional variation. In human DNA, it is always possible that a new, previously undiscovered (and therefore un-interrogated) site of variation may confer loss-of-function in an individual, and thus lead to the rare possibility of a non-functional allele being erroneously called as "wild-type."	3	1
ALLELE_DEFINITION	CYP2C9	Citations for assignment of function can be found at https://www.pharmgkb.org/page/cyp2c9RefMaterials	4	1
ALLELE_DEFINITION	CYP2C9	Content is accessed through the PharmVar API. HGVS and 'PharmVar-style' (accessible on the PharmVar website) positions may differ for indels in some instances which is most likely explained by differences in sequence alignments. Also, PharmVar displays single nucleotide insertions as 'ins' while the HGVS display is as duplications or 'dub' if the insertion is the same base as the prior base.	5	1
GENE_CDS	CYP2C9	The phenotype is used to store an interpretation of the test result. This is a design decision that may differ among sites. Assignment of all Genotype/Phenotype Summaries based on diplotype is available on the 'Possible CYP2C19' Diplotype tab.	0	1
GENE_CDS	CYP2C9	A priority result is defined as a genetic test result that results in a change in drug, drug dose, or drug monitoring.	1	1
GENE_CDS	CYP2C9	The specific wording of the interpretive text may differ among sites.	2	1
FREQUENCY	TPMT	For full references see "References" tab.	0	1
FREQUENCY	TPMT	Average frequencies based on the reported frequencies in one or multiple studies.	1	1
FREQUENCY	TPMT	Based on the PharmGKB biogeographical groups https://www.pharmgkb.org/page/biogeographicalGroups	2	1
FREQUENCY	TPMT	See the Allele Definition Tables at https://www.pharmgkb.org/page/tpmtRefMaterials for allele definitions	3	1
FREQUENCY	TPMT	Because TPMT*1 is not genotyped directly, all alleles that are negative for a sequence variation are defaulted to a TPMT*1 assignment. The inferred frequency for TPMT*1 is calculated as: 1 - (sum of averaged variant allele frequencies).	4	1
TEST_ALERT	RxNorm:7646	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:7646	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:7646	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:7646	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:140587	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:140587	Pharmacist, pharmacologist, or a clinician with pharmacogenetic expertise/training.	1	1
TEST_ALERT	RxNorm:7337	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:7337	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:1151	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:1151	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:1151	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:1151	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
ALLELE_DEFINITION	CYP2D6	The variants included in the alleles are based on the PharmVar core alleles (for core allele definitions only, see https://www.pharmvar.org/gene/CYP2D6). In addition, variants that present in the core allele for one star allele but also present in some but not all suballeles of another star allele are included in the other star allele as ambiguous changes using the IUPAC nucleotide code (https://www.bioinformatics.org/sms/iupac.html), e.g. the *4 consensus allele includes a "R" being either G or A (positive strand) at the 100C>T (P34S) position since this variant is part of other core star alleles, e.g. *10, but is not part of the *4 core allele at PharmVar since it is not present in all *4 suballeles. These postions are represented in grey (G) in the Comparative Allele ViewEr (CAVE) tool at PharmVar. The g.42129130C>G position is an exception. The SNP by itself causes a synonymous change, therefore by itself the SNP would not be part of a core allele based on the core allele definition. However, in *29 and *70 the SNP is needed for the amino acid change and therefore part of the *29 and *70 core allele definition in PharmVar. To follow the above, "S" is added at the position for star alleles in which not all suballeles carry the SNP. In case all suballeles have the SNP "G" is added.	0	1
ALLELE_DEFINITION	CYP2D6	At PharmVar, information about duplications and gene hybrids are available through https://www.pharmvar.org/gene-support/Variation_CYP2D6.pdf.	1	1
ALLELE_DEFINITION	CYP2D6	PharmVAR releases new alleles based on received submissions, see https://www.pharmvar.org for comprehensive haplotype definitions of CYP2D6 variant alleles, including sub-alleles, and updated allele information.	2	1
ALLELE_DEFINITION	CYP2D6	Amino acid changes are displayed per single variantion. However, in some alleles the 2 consecutive variants together cause a different amino acid change as each by itself. *29, *70: 1660G>A and 1662G>C result in V136I; *82: 1021A>T and 1022C>A result in T107Y; in exon 9 conversion: 4156C>T and 4157A>T result in H478S, 4168G>A and 4169C>G result in A482S	3	1
ALLELE_DEFINITION	CYP2D6	All variants are annotated to the positive DNA strand	4	1
ALLELE_DEFINITION	CYP2D6	rsID are RefSNP accession ID number (http://www.ncbi.nlm.nih.gov/snp/).	5	1
ALLELE_DEFINITION	CYP2D6	The CYP2D6*1 allele is characterized by the absence of any sequence variations. Consequently, this allele cannot be identified by a SNP; rather CYP2D6*1 is assigned by default when no SNPs are detected during testing.	6	1
ALLELE_DEFINITION	CYP2D6	The CYP2D6*2 allele is typically characterized by two amino acid changes; both, however also occur in many other CYP2D6 alleles. Therefore, if an allele carries these two SNPs exclusively, it is designated CYP2D6*2. Interrogating for additional SNPs is the only way to distinguish CYP2D6*2 from other alleles (e.g., CYP2D6*17 and *41).	7	1
ALLELE_DEFINITION	CYP2D6	4180G>C is present on many allelic variants including functional and non-functional variants. Specifically, it has been found on some CYP2D6*4 subvariants. While some tests include this SNP, it cannot be utilized to identify an allelic variant with certainty.	8	1
ALLELE_DEFINITION	CYP2D6	An important caveat for all genotyping tests is that the decision to assign an allele a wild-type status is based upon a genotyping test that interrogates only the most common and already- proven sites of functional variation. It is always possible that a novel, previously undiscovered (and therefore un-interrogated) site of variation may confer loss-of-function in an individual, and thus lead to the rare possibility of a non-functional allele being erroneously called as wild-type.	9	1
ALLELE_DEFINITION	CYP2D6	Content is accessed through the PharmVar API. HGVS and 'PharmVar-style' (accessible on the PharmVar website) positions may differ for indels in some instances which is most likely explained by differences in sequence alignments. Also, PharmVar displays single nucleotide insertions as 'ins' while the HGVS display is as duplications or 'dup' if the insertion is the same base as the prior base. The entries in the 'Free Text' field in row 2 reflect the default variant names on the CYP2D6 PharmVar page (https://www.pharmvar.org/gene/CYP2D6). Additional variant coordinates are consistent with the content displayed on the upper section of the 'Variant Positions' window which can be accessed by clicking on the variant of interest on the CYP2D6 PharmVar page.	10	1
GENE_CDS	CYP3A5	The coded diplotype/phenotype summary is used to store an interpretation of the test result. This is a design decision that may differ among sites. Assignment of all Genotype/Phenotype Summaries based on diplotype is available on the 'Possible CYP2C19' Diplotype tab.	0	1
GENE_CDS	CYP3A5	For this example, a priority result is defined as a genetic test result that results in a change in drug, drug dose, or drug monitoring.	1	1
GENE_CDS	CYP3A5	The specific wording of the interpretive text may differ among sites.	2	1
FREQUENCY	UGT1A1	For full references see "References" tab.	0	1
FREQUENCY	UGT1A1	Average frequencies are based on the actual number of subjects with each allele as reported in one or multiple studies.	1	1
FREQUENCY	UGT1A1	Based on the PharmGKB biogeographical groups https://www.pharmgkb.org/page/biogeographicalGroups	2	1
FREQUENCY	UGT1A1	See allele definition table (https://www.pharmgkb.org/page/ugt1a1RefMaterials) for allele definitions	3	1
FREQUENCY	UGT1A1	Because UGT1A1*1 is not genotyped directly, all alleles that are negative for a sequence variation are defaulted to a UGT1A1*1 assignment. The inferred frequency for UGT1A1*1 is calculated as: 1 - (sum of averaged variant allele frequencies).	4	1
TEST_ALERT	RxNorm:26225	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:26225	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:2348	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:2348	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:2348	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:2348	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:7454	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:7454	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:11258	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:11258	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:11258	The specific wording of the alert text may differ among sites.	2	1
ALLELE_DEFINITION	CYP3A5	The variants included are based on the PharmVar core alleles (for core alleles only see https://www.pharmvar.org/gene/CYP3a5).	0	1
ALLELE_DEFINITION	CYP3A5	See PharmVar website (http://www.pharmvar.org) for comprehensive haplotype definitions of CYP3A5 variant alleles, including sub-alleles, and updated allele information.	1	1
ALLELE_DEFINITION	CYP3A5	rsID=RefSNP accession ID number (http://www.ncbi.nlm.nih.gov/snp/)	2	1
ALLELE_DEFINITION	CYP3A5	All variants are annotated to the positive DNA strand.	3	1
ALLELE_DEFINITION	CYP3A5	An important caveat for all genotyping tests is that the decision to assign an allele a "wild- type" status is based upon a genotyping test that interrogates only the most common and already-proven sites of functional variation. In human DNA, it is always possible that a new, previously undiscovered (and therefore un-interrogated) site of variation may confer loss-of- function in an individual, and thus lead to the rare possibility of a non-functional allele being erroneously called as "wild-type"	4	1
ALLELE_DEFINITION	CYP3A5	Citations for assignment of function can be found at https://www.pharmgkb.org/page/cyp3a5RefMaterials	5	1
ALLELE_DEFINITION	CYP3A5	Content is accessed through the PharmVar API. HGVS and 'PharmVar-style' (accessible on the PharmVar website) positions may differ for indels in some instances which is most likely explained by differences in sequence alignments. Also, PharmVar displays single nucleotide insertions as 'ins' while the HGVS display is as duplications or 'dub' if the insertion is the same base as the prior base.	6	1
GENE_CDS	DPYD	The phenotype is used to store an interpretation of the test result. This is a design decision that may differ among sites.	0	1
GENE_CDS	DPYD	For this example, a priority result is defined as a genetic test result that results in a change in drug, drug dose, or drug monitoring.	1	1
GENE_CDS	DPYD	The specific wording of the interpretive text may differ among sites.	2	1
FREQUENCY	VKORC1	For full references see "References" tab.	0	1
FREQUENCY	VKORC1	Average frequencies based on the reported frequencies in one or multiple studies.	1	1
FREQUENCY	VKORC1	Based on the PharmGKB biogeographical groups https://www.pharmgkb.org/page/biogeographicalGroups	2	1
TEST_ALERT	RxNorm:32624	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:32624	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:2393	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:2393	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:2393	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:2393	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:7517	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:7517	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:7517	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:7517	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:11258	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
DIPLOTYPE_PHENOTYPE	RYR1	The CPIC guideline includes RYR1 variants assigned a Allele Clinical Functional Status of Normal function, Uncertain function, and Malignant Hyperthermia associated (see the "RYR1_allele_functionality_reference" file). A translation of Allele Function combinations to Phenotype is available in the "RYR1_phenotypes" file. It might be possible that a subject could have more than 2 RYR1 variants and this RYR1_Diplotype_Phenotype_Table is a representation of possible RYR1 genotypes considering the two functionally most impacted RYR1 variants.	0	1
ALLELE_DEFINITION	CYP4F2	rsID=RefSNP accession ID number (http://www.ncbi.nlm.nih.gov/snp/)	0	1
ALLELE_DEFINITION	CYP4F2	All variants are annotated to the positive DNA strand.	1	1
ALLELE_DEFINITION	CYP4F2	See PharmVar website (http://pharmvar.org) for comprehensive haplotype definitions of CYP4F2 variant alleles and updated allele information.	2	1
ALLELE_DEFINITION	CYP4F2	An important caveat for all genotyping tests is that the decision to assign an allele a "wild-type" status is based upon a genotyping test that interrogates only the most common and already-proven sites of functional variation. In human DNA, it is always possible that a new, previously undiscovered (and therefore un-interrogated) site of variation may confer loss-of-function in an individual, and thus lead to the rare possibility of a non-functional allele being erroneously called as "wild-type."	3	1
GENE_CDS	G6PD	For this example, a priority result is defined as a genetic test result that results in a change in drug, drug dose, or drug monitoring.	0	1
GENE_CDS	G6PD	The specific wording of the interpretive text may differ among sites.	1	1
TEST_ALERT	RxNorm:704	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:704	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:40790	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:40790	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:40790	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:40790	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:2551	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:2551	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:2551	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:2551	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:7623	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:7623	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:7623	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:7623	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:1455099	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:1455099	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
ALLELE_DEFINITION	DPYD	Variant selection is based on the CPIC guideline for Fluoropyrimidines and DPYD (https://cpicpgx.org/guidelines/guideline-for-fluoropyrimidines-and-dpyd/) and sourced from PharmVar (https://www.pharmvar.org/gene/DPYD).	0	1
ALLELE_DEFINITION	DPYD	All variants are annotated to the positive DNA strand.	1	1
ALLELE_DEFINITION	DPYD	As an individual only carries a maximum of two fully functional DPYD copies, common normal function variants may be located on the same gene copy as other normal	2	1
ALLELE_DEFINITION	DPYD	c.1129-5923C>G is likely the HapB3 haplotype causal variant. c.1236G>A (E412E) is a proxy SNP for HapB3.	3	1
ALLELE_DEFINITION	DPYD	Individual patients have been reported (PMID 38129972) to carry only one of the two SNPs in the HapB3 haplotype (i.e., c.1236G>A without c.1129-5923C>G), suggesting that the two variants are not in complete linkage disequilibrium. CPIC updated the allele definition to include the c.1129-5923C>G SNP separately as this is likely the causal variant leading to decreased function. CPIC also retained the HapB3 haplotype definition for cases where only the c.1236G>A variant is tested (e.g. whole exome sequencing). While CPIC recommends to directly test the causal SNP if possible, in cases where only c.1236G>A is tested or results are available for, it should be clearly stated in the test report that "decreased function" was inferred by detecting the exonic tag SNP, and disclose that in rare cases, the causal decreased function variant c.1129-5923C>G may not be present despite having this tag SNP.	4	1
ALLELE_DEFINITION	DPYD	c.680+139G>A is not exclusive to HapB3 and therefore not a suitable proxy.	5	1
ALLELE_DEFINITION	DPYD	rsID rs3918290, when combined with rs1801159, makes up DPYD*2B	6	1
ALLELE_DEFINITION	DPYD	rs56293913, rs3790387, rs2811202 are all part of a common haplotype that also encompasses c.496A>G (M166V).	7	1
ALLELE_DEFINITION	DPYD	The rs115632870 variant was found to be in linkage disequilibrium (D'=1) with the decreased function variant rs115232898 (Y186C); the decreased function associated with this variant is likely due to this linkage.	8	1
ALLELE_DEFINITION	DPYD	Content is accessed through the PharmVar API. HGVS and 'PharmVar-style' (accessible on the PharmVar website) positions may differ for indels in some instances which is most likely explained by differences in sequence alignments. Also, PharmVar displays single nucleotide insertions as 'ins' while the HGVS display is as duplications or 'dub' if the insertion is the same base as the prior base.	9	1
GENE_CDS	HLA-A	The phenotype is used to store an interpretation of the test result. This is a design decision that may differ among sites.	0	1
GENE_CDS	HLA-A	For this example, a priority result is defined as a genetic test result that results in a change in drug, drug dose, or drug monitoring.	1	1
GENE_CDS	HLA-A	The specific wording of the interpretive text may differ among sites.	2	1
TEST_ALERT	RxNorm:343047	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:343047	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:32937	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:32937	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:2670	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:2670	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:7934	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:7934	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
ALLELE_DEFINITION	G6PD	This modified table of G6PD variants is from PMID:22293322, https://grenada.lumc.nl/LOVD2/MR/home.php?select_db=G6PD, with several additional variants.	0	1
ALLELE_DEFINITION	G6PD	rsID=RefSNP accession ID number (http://www.ncbi.nlm.nih.gov/snp/)	1	1
ALLELE_DEFINITION	G6PD	All variants are annotated to the positive DNA strand.	2	1
ALLELE_DEFINITION	G6PD	Please note; WHO class as reported in PMID:22293322 and Luzzatto, L. & Poggi, V. Glucose-6-Phosphate Dehydrogenase Deficiency In: Nathan and Oski's Hematology of Infancy and Childhood, 7th Edition (ed. Meloni, D., Anderson, A. Authors of the book: Orkin, S.H., Fisher, D.E., Look, A.T., Lux IV, S.E., Ginsburg, D., Nathan, D.G. ) (Saunders, Elsevier., 2009) or individual references. This class may have been assigned based on just clinical\nmanifestations and not enzyme activity level or characterization of the enzyme variant.	3	1
ALLELE_DEFINITION	G6PD	Likely phenotype as referenced in this guideline, based on converting assigned WHO class to 3 phenotypes. "Normal" defined as very mild or no enzyme deficiency (>60% normal enzyme levels); "Deficient" defined as mild to severely deficient (<10-60% normal) enzyme levels; "Deficient with CNSHA" defined as severe G6PD enzyme deficiency (<10% activity) with chronic non-spherocytic hemolytic anemia based on Luzzatto, L. & Poggi, V. Glucose-6-Phosphate Dehydrogenase Deficiency In: Nathan and Oski's Hematology of Infancy and Childhood, 7th Edition (ed. Meloni, D., Anderson, A. Authors of the book: Orkin, S.H., Fisher, D.E., Look, A.T., Lux IV, S.E., Ginsburg, D., Nathan, D.G. ) (Saunders, Elsevier., 2009).	4	1
GENE_CDS	HLA-B	The phenotype is used to store an interpretation of the test result. This is a design decision that may differ among sites.	0	1
GENE_CDS	HLA-B	For this example, a priority result is defined as a genetic test result that results in a change in drug, drug dose, or drug monitoring.	1	1
GENE_CDS	HLA-B	The specific wording of the interpretive text may differ among sites.	2	1
TEST_ALERT	RxNorm:83367	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:83367	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:8183	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:8183	Pharmacist, pharmacologist, or a clinician with pharmacogenetic expertise/training.	1	1
TEST_ALERT	RxNorm:3108	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:3108	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:1011650	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:1011650	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
ALLELE_DEFINITION	IFNL3	rsID=RefSNP accession ID number (http://www.ncbi.nlm.nih.gov/snp/)	0	1
ALLELE_DEFINITION	IFNL3	All variants are annotated to the positive DNA strand.	1	1
GENE_CDS	MT-RNR1	The phenotype is used to store an interpretation of the test result. This is a design decision that may differ among sites.	0	1
GENE_CDS	MT-RNR1	For this example, a priority result is defined as a genetic test result that results in a change in drug, drug dose, or drug monitoring.	1	1
GENE_CDS	MT-RNR1	The specific wording of the interpretive text may differ among sites.	2	1
TEST_ALERT	RxNorm:2002	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:2002	"Clinical Pharmacist" could be a pharmacist, pharmacologist, or a clinician with pharmacogenetic expertise/training.	1	1
TEST_ALERT	RxNorm:8356	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:8356	Pharmacist, pharmacologist, or a clinician with pharmacogenetic expertise/training.	1	1
TEST_ALERT	RxNorm:3328	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:3328	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:8120	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:8120	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:8120	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:8120	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
ALLELE_DEFINITION	MT-RNR1	Variant selection based on the CPIC guideline for aminoglycoside antibiotics and MT-RNR1.	0	1
GENE_CDS	NAT2	The phenotype is used to store an interpretation of the test result. This is a design decision that may differ among sites.	0	1
GENE_CDS	NAT2	For this example, a priority result is defined as a genetic test result that results in a change in drug, drug dose, or drug monitoring.	1	1
GENE_CDS	NAT2	The specific wording of the interpretive text may differ among sites.	2	1
TEST_ALERT	RxNorm:2556	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:2556	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:861634	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:861634	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:3445	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:3445	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:3445	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:3445	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:2049549	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:2049549	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
DIPLOTYPE_PHENOTYPE	DPYD	It is possible that a subject has > 2 DPYD variants and this DPYD_Diplotype_Phenotype_Table is a representation of possible DPYD genotypes considering the two functionally most impacted (lowest activity value) variants. Based on the CPIC guideline for Dihydropyrimidine Dehydrogenase Genotype and Fluoropyrimidine Dosing: 2017 Update (PMID: 29152729), the DPD phenotype is assigned using a gene activity score (DPYD-AS; based on the DPYD Allele Functionality Table), calculated as the sum of the two DPYD variants with the lowest variant activity value. A translation of Allele Function combinations to Phenotype is available in the "DPYD_phenotypes" file. If two decreased/no function variants are present, each decreased/no function variant is considered to be on a different gene copy when the phase is not known.	0	1
ALLELE_DEFINITION	NAT2	rsID = RefSNP accession ID number (http://www.ncbi.nlm.nih.gov/snp/)	0	1
ALLELE_DEFINITION	NAT2	All variants are annotated to the positive DNA strand.	1	1
ALLELE_DEFINITION	NAT2	Structural variants are represented using the PharmVar ID.	2	1
ALLELE_DEFINITION	NAT2	See PharmVar website (http://www.pharmvar.org) for comprehensive haplotype definitions of NAT2 variant alleles and updated allele information.	3	1
ALLELE_DEFINITION	NAT2	An important caveat for all genotyping tests is that the decision to assign an allele a "wild-type" status is based upon a genotyping test that interrogates only the most common and already-proven sites of functional variation. In human DNA, it is always possible that a new, previously undiscovered (and therefore un-interrogated) site of variation may confer loss-of-function in an individual, and thus lead to the rare possibility of a non-functional allele being erroneously called as "wild-type."	4	1
ALLELE_DEFINITION	NAT2	Some drastic changes have been made to NAT2 nomenclature during transition from the original (Database of Arylamine N-Acetyltransferases (NATs)) to the new (https://www.pharmvar.org/gene/NAT2) "star" allele definitions:	5	1
ALLELE_DEFINITION	NAT2	The NAT2 reference allele has now changed: The NG_012246.1 RefSeq differs from X14672.1 (which was used in the past to define star alleles) at the position that corresponds to c.803 (rs1208), where X14672.1 has "A" while NG_012246.1 has "G". Thus, depending on which reference sequence is utilized, this position is reported as either reference or variant. The transition of allele definitions to the NG_012246.1 RefSeq caused "variant switching", meaning that all star alleles which were previously described as having c.803A>G lost this variant, as "G" is now considered reference, while all other star alleles gained c.803G>A, as "A" is now considered variant.	6	1
ALLELE_DEFINITION	NAT2	The new reference allele is now catalogued as NAT2*1: The sequence of NG_012246.1 RefSeq corresponds to the allele that was formerly described as NAT2*12A. Its renaming as NAT2*1.001 facilitates the application of PharmVar rules to NAT2 allelic nomenclature, while it also enables the use of NAT2*1 name to describe the reference allele, in line with the star allele nomenclature of other pharmacogenes. To avoid confusion during the transition from the legacy to the new nomenclature, *12 is now retired. Having a NAT2*1 allele grouping in place also facilitates NGS analyses using GRCh38 as a reference.	7	1
GENE_CDS	NUDT15	The phenotype is used to store an interpretation of the test result. This is a design decision that may differ among sites.	0	1
GENE_CDS	NUDT15	For this example, a priority result is defined as a genetic test result that results in a change in drug, drug dose, or drug monitoring.	1	1
GENE_CDS	NUDT15	The specific wording of the interpretive text may differ among sites.	2	1
TEST_ALERT	RxNorm:2597	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:2597	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:42463	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:42463	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:3639	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:3639	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:3639	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:3639	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:8687	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:8687	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:8687	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:8687	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
ALLELE_DEFINITION	NAT2	NAT2*4 is no longer considered as the reference allele: Alleles carrying c.803G>A as their only amino acid changing SNV will be called as *4 according to the new nomenclature. This includes the former NAT2*4 reference allele of sequence X14672.1, now considered a variant and listed as NAT2*4.001. Although this will no longer be used as a reference, it is considered to be functionally equivalent to NAT2*1.001 (formerly NAT2*12A) and may still be used to compare the enzymatic or structural properties of polymorphic NAT2 proteins.	8	1
ALLELE_DEFINITION	NAT2	Not all previously defined star alleles have been transferred: In the past, it has not always been clear how a NAT2 haplotype was determined. Many have been inferred via computational phase analysis and were not verified experimentally. In the case of haplotypes where the available evidence from the literature was deemed insufficient to support confident allele definition, those haplotypes were not transferred to PharmVar, but they will remain posted on the original Database of Arylamine N-Acetyltransferases (NATs).	9	1
ALLELE_DEFINITION	NAT2	This file contains the PharmVar NAT2 core allele definitions.	10	1
ALLELE_DEFINITION	NAT2	Alleles with content annotated in PharmGKB but not included in PharmVar (*5G, *5J, *5M, *5U, *6J, *7G, *17) are added using the the original Database of Arylamine N-Acetyltransferases (NATs, http://nat.mbg.duth.gr/Human%20NAT2%20alleles_2013.htm) definitions. This results in the inclusion of 2 synonymous SNPs (added in grey). PharmVar NAT2 core alleles do not include these SNPs although those are part of many NAT2 suballeles and the cells in the core alleles are therefore left blank in this file (see PharmVar for all transitioned NAT2 suballeles and about what is included in a core allele definition). Additionally, with transitioning to PharmVar, the change at p.268 is now according to the reference sequence R268K (see above information). Therefore, original definitions that include K268R will have a blank cell, while alleles that did not include the SNP will now have an "A" at this position.\nPositions added: \n226T>G part of *7G\n434A>C part of *17\n282C>T and 481C>T synonymous SNPs\n*5G has K268R - 803G =ref at this position, therefore blank\n*5J has 803A \n*5M has K268R - 803G =ref at this position, therefore blank\n*5U has K268R - 803G =ref at this position, therefore blank\n*6J has 803A \n*7G has 803A \n*17 has 803A	11	1
GENE_CDS	RYR1	The phenotype is used to store an interpretation of the test result. This is a design decision that may differ among sites.	0	1
GENE_CDS	RYR1	For this example, a priority result is defined as a genetic test result that results in a change in drug, drug dose, or drug monitoring.	1	1
GENE_CDS	RYR1	The specific wording of the interpretive text may differ among sites.	2	1
TEST_ALERT	RxNorm:32968	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:32968	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:301542	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:301542	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:4492	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:4492	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:9071	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:9071	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:9071	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:9071	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
ALLELE_DEFINITION	NUDT15	PharmVAR releases new alleles based on received submissions, see https://www.pharmvar.org/gene/NUDT15 for comprehensive haplotype definitions of NUDT15 variant alleles, including sub-alleles, and updated allele information.	0	1
ALLELE_DEFINITION	NUDT15	The variants included in the alleles are based on the PharmVar core alleles (for core allele definitions only, see https://www.pharmvar.org/gene/NUDT15). In addition, variants that present in the core allele for one star allele but also present in some but not all suballeles of another star allele are included in the other star allele as ambiguous changes, e.g. the *3 consensus allele includes a "GAGTCG(3) or GAGTCG(4)" at the position 55_56insGAGTCG since this variant defines the *6 core allele but is not part of the *3 core allele definition in PharmVar since it is not present in all *3 suballeles. These postions are represented in grey (G) in the Comparative Allele ViewEr (CAVE) tool at PharmVar.	1	1
ALLELE_DEFINITION	NUDT15	rsID=RefSNP accession ID number (http://www.ncbi.nlm.nih.gov/snp/)	2	1
ALLELE_DEFINITION	NUDT15	All variants are annotated to the positive DNA strand.	3	1
ALLELE_DEFINITION	NUDT15	rs554405994 was merged into rs869320766 which was merged into rs746071566	4	1
ALLELE_DEFINITION	NUDT15	Content is accessed through the PharmVar API. HGVS and 'PharmVar-style' (accessible on the PharmVar website) positions may differ for indels in some instances which is most likely explained by differences in sequence alignments. Also, PharmVar displays single nucleotide insertions as 'ins' while the HGVS display is as duplications or 'dub' if the insertion is the same base as the prior base.	5	1
GENE_CDS	SLCO1B1	The phenotype is used to store an interpretation of the test result. This is a design decision that may differ among sites.	0	1
GENE_CDS	SLCO1B1	For this example, a priority result is defined as a genetic test result that results in a change in drug, drug dose, or drug monitoring.	1	1
GENE_CDS	SLCO1B1	The specific wording of the interpretive text may differ among sites.	2	1
TEST_ALERT	RxNorm:27340	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:27340	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:36437	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:36437	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:4502	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:4502	Pharmacist, pharmacologist, or a clinician with pharmacogenetic expertise/training.	1	1
TEST_ALERT	RxNorm:283821	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:283821	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
ALLELE_DEFINITION	RYR1	Variant selection based on an update of the CPIC guideline for potent volatile anesthetic agents and succinylcholine. The guideline update includes the published list of RYR1 variants (supplemental table S2), which are evaluated by the ClinGen malignant hyperthermia susceptibility (MHS) variant curation expert panel and classified for RYR1-related malignant hyperthermia susceptibility based on specified the ACMG/AMP criteria (PMID 35849058).	0	1
ALLELE_DEFINITION	RYR1	The deletion of an E can be represented as E2347del orE2348del (c.7039_7041delGAG or c.7042_7044delGAG, respectivly). c.7042_7044delGAG is used to name the variant in the file to reflect the ClinGen naming, however the mapping of the variant is done according to the corresponding rsID rs121918596.	1	1
GENE_CDS	TPMT	The phenotype is used to store an interpretation of the test result. This is a design decision that may differ among sites.	0	1
GENE_CDS	TPMT	For this example, a priority result is defined as a genetic test result that results in a change in drug, drug dose, or drug monitoring.	1	1
GENE_CDS	TPMT	The specific wording of the interpretive text may differ among sites.	2	1
TEST_ALERT	RxNorm:3247	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:3247	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:36453	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:36453	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:4601	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:4601	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:4601	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:4601	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:NA	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:NA	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
ALLELE_DEFINITION	SLCO1B1	rsID=RefSNP accession ID number (http://www.ncbi.nlm.nih.gov/snp/)	0	1
ALLELE_DEFINITION	SLCO1B1	All variants are annotated to the positive DNA strand.	1	1
ALLELE_DEFINITION	SLCO1B1	An important caveat for all genotyping tests is that the decision to assign an allele a "wild-type" status is based upon a genotyping test that interrogates only the most common and already-proven sites of functional variation. In human DNA, it is always possible that a new, previously undiscovered (and therefore un-interrogated) site of variation may confer loss-of-function in an individual, and thus lead to the rare possibility of a non-functional allele being erroneously called as "wild-type."	2	1
ALLELE_DEFINITION	SLCO1B1	Citations for assignment of function can be found at https://www.pharmgkb.org/page/slco1b1RefMaterials	3	1
GENE_CDS	UGT1A1	The phenotype is used to store an interpretation of the test result. This is a design decision that may differ among sites.	0	1
GENE_CDS	UGT1A1	For this example, a priority result is defined as a genetic test result that results in a change in drug, drug dose, or drug monitoring.	1	1
GENE_CDS	UGT1A1	The specific wording of the interpretive text may differ among sites.	2	1
TEST_ALERT	RxNorm:816346	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:816346	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:816346	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:816346	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:36567	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:36567	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	ATC:D06AX07	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	ATC:D06AX07	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:10109	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:10109	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
FREQUENCY	CACNA1S	For full references see "References" tab.	0	1
TEST_ALERT	RxNorm:3638	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:3638	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:10154	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:10154	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:4815	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:4815	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:4815	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:4815	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:10171	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:10171	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:10171	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:10171	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
ALLELE_DEFINITION	TPMT	rsID=RefSNP accession ID number (http://www.ncbi.nlm.nih.gov/snp/)	0	1
ALLELE_DEFINITION	TPMT	All variants are annotated to the positive DNA strand.	1	1
ALLELE_DEFINITION	TPMT	Variants are sourced from the TPMT nomenclature committee (TPMT Alleles), see https://liu.se/en/research/tpmt-nomenclature-committee	2	1
FREQUENCY	CYP2B6	For full references see "references" tab.	0	1
FREQUENCY	CYP2B6	Average frequencies based on the reported frequencies in one or multiple studies.	1	1
ALLELE_DEFINITION	UGT1A1	rsID=RefSNP accession ID number (http://www.ncbi.nlm.nih.gov/snp/)	0	1
ALLELE_DEFINITION	UGT1A1	All variants are annotated to the positive DNA strand.	1	1
ALLELE_DEFINITION	UGT1A1	To see a full list of known UGT1A1 alleles see https://www.pharmacogenomics.pha.ulaval.ca/wp-content/uploads/2015/04/UGT1A1-allele-nomenclature.html	2	1
ALLELE_DEFINITION	UGT1A1	An important caveat for all genotyping tests is that the decision to assign an allele a "wild-type" status is based upon a genotyping test that interrogates only the most common and already- proven sites of functional variation. In human DNA, it is always possible that a new, previously undiscovered (and therefore un-interrogated) site of variation may confer loss-of-function in an individual, and thus lead to the rare possibility of a non-functional allele being erroneously called as "wild-type".	3	1
ALLELE_DEFINITION	UGT1A1	Citations for assignment of function can be found at https://www.pharmgkb.org/page/ugt1a1RefMaterials	4	1
ALLELE_DEFINITION	UGT1A1	UGT1A1*80 is in very high linkage disequilibrium with *28 and *37. However, the function of the *80 allele alone, in the absence of *28 or *37, is uncertain. If a patient is only tested for *80, decreased function may be inferred, though linkage is not 100%.	5	1
ALLELE_DEFINITION	UGT1A1	TA repeat: Historically in the literature and at the UGT nomenclature website, the TA repeat is referred to as TA(6) for *1, TA(7) for *28, TA(5) for *36, etc. The UGT allele nomenclature website (https://www.pharmacogenomics.pha.ulaval.ca/wp-content/uploads/2015/04/UGT1A1-allele-nomenclature.html) defines them in more detail as for example: A(TA)6TAA to A(TA)7TAA for *28 and A(TA)6TAA to A(TA)5TAA for *36. Note that after the repeat and number, there is an additional TA listed in the flanking sequence as "TAA". Similar nomenclature/representation is in cell C2 of the table on the "Alleles" tab as historical referencing ("CA" in front as an anchor for the point in the sequence that the TA repeats are starting from). Rows 4 and 5 align with the indicated reference sequences. In cells C4 and C5, when counting from the first TA at the given position in the sequence and including the last TA, the 5, 6, 7, 8 repeats become 6, 7, 8, 9 because there are actually 6 to 9 "TA" repeats in the genomic and gene reference sequences.	6	1
FREQUENCY	CYP2B6	Based on the PharmGKB biogeographical groups https://www.pharmgkb.org/page/biogeographicalGroups	2	1
FREQUENCY	CYP2B6	See allele definition table (https://www.pharmgkb.org/page/cyp2b6RefMaterials) for allele definitions	3	1
FREQUENCY	CYP2B6	Because CYP2B6*1 is not genotyped directly, all alleles that are negative for a sequence variation are defaulted to a CYP2B6*1 assignment. The inferred frequency for CYP2B6*1 is calculated as: 1 - (sum of averaged variant allele frequencies).	4	1
TEST_ALERT	RxNorm:195085	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:195085	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:42316	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:42316	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:5470	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:5470	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:10178	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:10178	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:10178	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:10178	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
FREQUENCY	CYP2C9	For full references see "References" tab.	0	1
FREQUENCY	CYP2C9	Average frequencies based on the reported frequencies in one or multiple studies.	1	1
FREQUENCY	CYP2C9	Based on the PharmGKB biogeographical groups https://www.pharmgkb.org/page/biogeographicalGroups	2	1
FREQUENCY	CYP2C9	See allele definition table (https://www.pharmgkb.org/page/cyp2c9RefMaterials) for allele definitions	3	1
FREQUENCY	CYP2C9	Because CYP2C9*1 is not genotyped directly, all alleles that are negative for a sequence variation are defaulted to a CYP2C9*1 assignment. The inferred frequency for CYP2C9*1 is calculated as: 1 - (sum of averaged variant allele frequencies).	4	1
ALLELE_DEFINITION	VKORC1	rsID=RefSNP accession ID number (http://www.ncbi.nlm.nih.gov/snp/)	0	1
ALLELE_DEFINITION	VKORC1	All variants are annotated to the positive DNA strand.	1	1
TEST_ALERT	RxNorm:3920	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:3920	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:10324	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:10324	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:5489	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:5489	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:10831	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:10831	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:10831	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:10831	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
FREQUENCY	CYP2D6	In the Sub-Saharan African group, presented data for Twesigomwe et al., 2022 PMID 36111505 is a combination of frequencies from PMID 36111505 and Wang et al. 2022 PMID 36294714. See the Methods and Caveats tab for how *1 frequencies are determined for this file.	0	1
TEST_ALERT	RxNorm:321988	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:321988	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:37790	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:37790	Pharmacist, pharmacologist, or a clinician with pharmacogenetic expertise/training.	1	1
TEST_ALERT	RxNorm:5521	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:5521	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:5521	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:5521	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:10184	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:10184	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:10184	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:10184	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
FREQUENCY	CYP3A5	For full references see "References" tab.	0	1
FREQUENCY	CYP3A5	Average frequencies based on the reported frequencies in one or multiple studies.	1	1
FREQUENCY	CYP3A5	Based on the PharmGKB biogeographical groups https://www.pharmgkb.org/page/biogeographicalGroups	2	1
FREQUENCY	CYP3A5	See the Allele Definition Table at http://www.pharmgkb.org/cyp3a5RefMaterials for allele definitions	3	1
FREQUENCY	CYP3A5	Because CYP3A5*1 is not genotyped directly, all alleles that are negative for a sequence variation are defaulted to a CYP3A5*1 assignment. The inferred frequency for CYP3A5*1 is calculated as: 1 - (sum of averaged variant allele frequencies).	4	1
TEST_ALERT	RxNorm:41127	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:41127	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:10834	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:10834	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:5640	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:5640	Pharmacist, pharmacologist, or a clinician with pharmacogenetic expertise/training.	1	1
TEST_ALERT	RxNorm:9524	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:9524	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:9524	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:9524	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
FREQUENCY	CYP4F2	For full references see "references" tab.	0	1
FREQUENCY	CYP4F2	Average frequencies based on the reported frequencies in one or multiple studies.	1	1
FREQUENCY	CYP4F2	Based on the PharmGKB biogeographical groups https://www.pharmgkb.org/page/biogeographicalGroups	2	1
FREQUENCY	CYP4F2	See allele definition table (https://www.pharmgkb.org/page/cyp4f2RefMaterials) for allele definitions	3	1
FREQUENCY	CYP4F2	Because CYP4F2*1 is not genotyped directly, all alleles that are negative for a sequence variation are defaulted to a CYP4F2*1 assignment. The inferred frequency for CYP4F2*1 is calculated as: 1 - (sum of averaged variant allele frequencies).	4	1
TEST_ALERT	RxNorm:42355	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:42355	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:121243	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:121243	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:121243	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:121243	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:6099	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:6099	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:10207	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:10207	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:10207	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:10207	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
FREQUENCY	DPYD	Both variants in c.1129-5923C>G, c.1236G>A (HapB3) are listed with identical frequencies in 1000 Genomes	0	1
FREQUENCY	DPYD	For full references see "References" tab.	1	1
FREQUENCY	DPYD	Average frequencies based on the reported frequencies in one or multiple studies.	2	1
FREQUENCY	DPYD	Based on the PharmGKB biogeographical groups https://www.pharmgkb.org/page/biogeographicalGroups	3	1
FREQUENCY	DPYD	See allele definition table (https://www.pharmgkb.org/page/dpydRefMaterials) for allele definitions	4	1
TEST_ALERT	RxNorm:72236	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:72236	Pharmacist, pharmacologist, or a clinician with pharmacogenetic expertise/training.	1	1
TEST_ALERT	RxNorm:190521	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:190521	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:20890	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:20890	Pharmacist, pharmacologist, or a clinician with pharmacogenetic expertise/training.	1	1
TEST_ALERT	RxNorm:2054023	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:2054023	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
FREQUENCY	G6PD	The allele frequency table was made by searching the gnomAD database v2.1.1 except for Cairo from v3.1.2	0	1
FREQUENCY	G6PD	Based on the PharmGKB biogeographical groups https://www.pharmgkb.org/page/biogeographicalGroups	1	1
FREQUENCY	G6PD	See allele definition table (https://www.pharmgkb.org/page/g6pdRefMaterials) for allele definitions	2	1
FREQUENCY	G6PD	Because B(reference) is not genotyped directly, all alleles that are negative for a sequence variation are defaulted to a B (reference) assignment. The inferred frequency for B(reference) is calculated as: 1 - (sum of averaged variant allele frequencies) but this may not be accurate since there are many variants with no known frequency.	3	1
FREQUENCY	G6PD	Note that gnomAD does not calculate haploytpe frequencies. Some haplotypes have frequencies in this spreadsheet if a unique allele in the haplotype has frequency information in gnomAD AND if the other variant in the haplotype is known to have normal function	4	1
FREQUENCY	G6PD	Note that some variants in this spreadsheet can either be found alone or in a haplotype (in combination with other variants). Therefore the frequency reported MAY NOT BE FOR THE VARIANT ALONE, BUT ALSO FOR THE VARIANT IF FOUND IN A HAPLOTYPE.	5	1
TEST_ALERT	RxNorm:5095	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:5095	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:519	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:519	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:6572	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:6572	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:6572	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:6572	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:10485	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:10485	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
FREQUENCY	HLA-A	For full references see "References" tab.	0	1
FREQUENCY	HLA-A	Average frequencies based on the reported frequencies in one or multiple studies.	1	1
FREQUENCY	HLA-A	Based on the PharmGKB biogeographical groups https://www.pharmgkb.org/page/biogeographicalGroups	2	1
TEST_ALERT	RxNorm:5691	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:5691	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:641	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:641	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:41493	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:41493	Pharmacist, pharmacologist, or a clinician with pharmacogenetic expertise/training.	1	1
TEST_ALERT	RxNorm:10627	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:10627	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
FREQUENCY	HLA-B	For full references see "References" tab.	0	1
FREQUENCY	HLA-B	aAverage frequencies based on the reported frequencies in one or multiple studies.	1	1
FREQUENCY	HLA-B	bBased on the PharmGKB biogeographical groups https://www.pharmgkb.org/page/biogeographicalGroups	2	1
TEST_ALERT	RxNorm:6026	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:6026	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:7833	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:7833	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:7833	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:7833	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:103	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:103	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:10635	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:10635	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:10635	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:10635	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
ALLELE_FUNCTION_REFERENCE	CYP2B6	CYP2B6 functional metabolic effects may be substrate specific (and extrapolations to other substrates may not be reliable).	0	1
\.


--
-- Data for Name: flyway_schema_history; Type: TABLE DATA; Schema: cpic; Owner: -
--

COPY cpic.flyway_schema_history (installed_rank, version, description, type, script, checksum, installed_by, installed_on, execution_time, success) FROM stdin;
1	1	Initial bootstrap	SQL	V1__Initial_bootstrap.sql	1343833882	cpic	2020-09-30 21:02:41.398674	17646	t
2	2	initial data	SQL	V2__initial_data.sql	1569953039	cpic	2020-09-30 21:03:00.181244	1464	t
3	3	views	SQL	V3__views.sql	1637573145	cpic	2020-09-30 21:03:02.68466	2906	t
4	4	flow charts	SQL	V4__flow_charts.sql	-461764197	cpic	2020-09-30 21:03:06.637242	3674	t
5	6	nsaid release	SQL	V6__nsaid_release.sql	1899796322	cpic	2020-09-30 21:03:11.349979	2479	t
6	7	nsaid pair data	SQL	V7__nsaid_pair_data.sql	-1759040576	cpic	2020-09-30 21:03:14.862537	1507	t
7	8	data progress view	SQL	V8__data_progress_view.sql	-583739949	cpic	2020-09-30 21:03:17.405314	325	t
8	9	file view	SQL	V9__file_view.sql	-435728782	cpic	2020-09-30 21:03:18.784115	320	t
9	10	pair data update	SQL	V10__pair_data_update.sql	1561416759	cpic	2020-09-30 21:03:20.133162	720	t
10	11	guideline in drug model	SQL	V11__guideline_in_drug_model.sql	1721141764	cpic	2020-09-30 21:03:21.898691	476	t
11	12	pair data update	SQL	V12__pair_data_update.sql	-1970090295	cpic	2020-09-30 21:03:23.402028	233	t
12	13	add publications	SQL	V13__add_publications.sql	1291951866	cpic	2020-09-30 21:03:24.679997	320	t
13	14	add highlighted publications	SQL	V14__add_highlighted_publications.sql	759335679	cpic	2020-09-30 21:03:26.044179	399	t
14	15	pair data update	SQL	V15__pair_data_update.sql	81113836	cpic	2020-09-30 21:03:27.481903	243	t
15	16	update ibuprofen ATC	SQL	V16__update_ibuprofen_ATC.sql	1407599949	cpic	2020-09-30 21:03:28.777477	243	t
16	18	allele status lookup	SQL	V18__allele_status_lookup.sql	-859499970	cpic	2020-09-30 21:03:30.070317	482	t
17	19	new publication	SQL	V19__new_publication.sql	-1342471317	cpic	2020-09-30 21:03:31.581321	315	t
18	20	update sequence IDs	SQL	V20__update_sequence_IDs.sql	-75396910	cpic	2020-09-30 21:03:32.939966	480	t
19	21	recommendation lookup fn	SQL	V21__recommendation_lookup_fn.sql	-1422255981	cpic	2020-09-30 21:03:34.466215	478	t
20	22	ppi release	SQL	V22__ppi_release.sql	-1608844545	cpic	2020-09-30 21:03:35.973984	885	t
21	23	helpful views	SQL	V23__helpful_views.sql	1737227498	cpic	2020-09-30 21:03:37.894656	1362	t
22	24	new drug flowcharts	SQL	V24__new_drug_flowcharts.sql	426101726	cpic	2020-09-30 21:03:40.286768	888	t
23	25	phenytoin guideline update	SQL	V25__phenytoin_guideline_update.sql	-746232628	cpic	2020-09-30 21:03:42.235826	481	t
24	26	validate pair pmids	SQL	V26__validate_pair_pmids.sql	-1806818774	cpic	2020-09-30 21:03:43.755407	240	t
25	27	reference allele	SQL	V27__reference_allele.sql	849245471	cpic	2020-09-30 21:03:45.03582	1701	t
26	\N	apply permissions	SQL	R__apply_permissions.sql	-1445996752	cpic	2020-09-30 21:03:47.781042	1352	t
27	28	more allele frequency	SQL	V28__more_allele_frequency.sql	805701621	cpic	2020-10-06 04:45:31.882019	65	t
28	29	gene notes on diplotype	SQL	V29__gene_notes_on_diplotype.sql	-32272162	cpic	2020-10-06 04:45:31.979835	39	t
29	30	fix diplotype note column name	SQL	V30__fix_diplotype_note_column_name.sql	-1780194441	cpic	2020-10-06 20:33:55.825135	12	t
30	31	structural variant alleles	SQL	V31__structural_variant_alleles.sql	907385290	cpic	2020-10-21 16:33:11.171586	21	t
31	32	more notes	SQL	V32__more_notes.sql	946380705	cpic	2020-10-26 04:13:26.606463	33	t
32	33	remove allele frequency	SQL	V33__remove_allele_frequency.sql	370457724	cpic	2020-10-29 02:34:55.945477	28	t
33	34	add constraints to publication	SQL	V34__add_constraints_to_publication.sql	1822736403	cpic	2020-12-07 19:33:55.270759	86	t
34	35	opioid release	SQL	V35__opioid_release.sql	-334675632	cpic	2021-01-08 00:30:17.865038	51	t
35	36	update allele view	SQL	V36__update_allele_view.sql	-926799802	cpic	2021-01-15 23:54:12.278947	96	t
36	37	remove unused column	SQL	V37__remove_unused column.sql	-2122981860	cpic	2021-03-25 17:42:36.558878	134	t
37	38	gene urls	SQL	V38__gene_urls.sql	1563545318	cpic	2021-03-25 17:42:36.742551	62	t
38	\N	apply permissions	SQL	R__apply_permissions.sql	-575065814	cpic	2021-03-25 17:42:36.82488	28	t
39	39	guideline summary view	SQL	V39__guideline_summary_view.sql	480060255	cpic	2021-03-26 20:19:53.149371	58	t
40	\N	apply permissions	SQL	R__apply_permissions.sql	-1861354715	cpic	2021-03-26 20:19:53.225004	31	t
41	40	fix flowchart urls	SQL	V40__fix_flowchart_urls.sql	-1456884835	cpic	2021-05-11 18:22:43.25079	46	t
43	42	aminoglycosides guideline	SQL	V42__aminoglycosides_guideline.sql	540949488	cpic	2021-06-14 04:40:37.690857	93	t
44	43	seq loc unique key	SQL	V43__seq_loc_unique_key.sql	-1638696174	cpic	2021-06-14 04:40:37.808891	52	t
45	44	functionmethods	SQL	V44__functionmethods.sql	2079604482	cpic	2021-06-29 15:43:53.422219	16	t
46	45	sequence location position	SQL	V45__sequence_location_position.sql	1314277241	cpic	2021-07-09 21:30:29.833003	102	t
47	46	fix dbsnpid column	SQL	V46__fix_dbsnpid_column.sql	-1850897598	cpic	2021-08-05 17:38:43.759722	21	t
48	47	guideline fns	SQL	V47__guideline_fns.sql	-1198346012	cpic	2021-08-18 22:14:26.14922	30	t
49	48	update guideline allele fn	SQL	V48__update_guideline_allele_fn.sql	-1854568090	cpic	2021-09-09 21:03:26.214156	30	t
50	49	fix allele findings	SQL	V49__fix_allele_findings.sql	976892510	cpic	2021-09-09 21:03:26.268771	65	t
51	50	fix IFNL3 lookup	SQL	V50__fix_IFNL3_lookup.sql	119727388	cpic	2021-10-13 17:22:27.82421	9	t
52	51	fix guideline allele fn	SQL	V51__fix_guideline_allele_fn.sql	798068262	cpic	2021-11-10 05:57:09.346894	62	t
53	52	recommendation alleles view	SQL	V52__recommendation_alleles_view.sql	-1879594301	cpic	2021-12-07 15:59:50.932388	98	t
54	\N	apply permissions	SQL	R__apply_permissions.sql	-1576403970	cpic	2021-12-07 15:59:51.080556	20	t
55	53	statins guideline	SQL	V53__statins_guideline.sql	-374639719	cpic	2022-02-16 23:10:42.374259	18	t
56	54	publication index	SQL	V54__publication_index.sql	-1084867310	cpic	2022-02-18 22:16:35.644864	11	t
57	55	allele frequency cache	SQL	V55__allele_frequency_cache.sql	778761699	cpic	2022-03-09 23:20:36.042025	13	t
58	56	gene legacy names	SQL	V56__gene_legacy_names.sql	-442391864	cpic	2022-03-17 23:13:23.411535	13	t
59	57	pgkb recs fn update	SQL	V57__pgkb_recs_fn_update.sql	415609266	cpic	2022-06-10 14:24:09.906199	22	t
42	41	publication files	SQL	V41__publication_files.sql	389573953	cpic	2021-05-11 18:22:43.398622	319	t
60	\N	apply permissions	DELETE	R__apply_permissions.sql	-1576403970	cpic	2022-08-16 07:29:30.595272	0	t
61	58	stats table	SQL	V58__stats_table.sql	1603923816	cpic	2022-08-16 07:35:43.159887	60	t
62	59	remove allele guideline	SQL	V59__remove_allele_guideline.sql	-1144551837	cpic	2022-09-14 17:55:53.477071	21	t
63	60	reference allele	SQL	V60__reference_allele.sql	1296637883	cpic	2022-09-14 17:55:53.52649	26	t
64	61	G6PD guideline prep	SQL	V61__G6PD_guideline_prep.sql	1983975991	cpic	2022-09-14 17:55:53.577532	28	t
65	62	G6PD flow charts	SQL	V62__G6PD_flow_charts.sql	626814934	cpic	2022-09-22 16:42:28.143006	29	t
66	63	fosphenytoin flow chart	SQL	V63__fosphenytoin_flow_chart.sql	1952328724	cpic	2022-09-30 13:34:29.608278	28	t
67	64	recommendation flags	SQL	V64__recommendation_flags.sql	-797174188	cpic	2023-02-27 19:42:13.143746	42	t
68	65	frequency flags	SQL	V65__frequency_flags.sql	-477833361	cpic	2023-03-23 11:54:36.147354	42	t
69	66	ssri snri guideline	SQL	V66__ssri_snri_guideline.sql	-1949888557	cpic	2023-04-12 19:43:47.434594	34	t
70	67	frequency view fix	SQL	V67__frequency_view_fix.sql	-1816979743	cpic	2023-09-01 14:42:15.154823	41	t
71	68	fix function definitions	SQL	V68__fix_function_definitions.sql	1243132888	cpic	2024-01-12 20:33:40.207106	11	t
72	69	change log releases	SQL	V69__change_log_releases.sql	1272931372	cpic	2024-05-09 15:03:57.003783	276	t
73	70	fix allele freq view	SQL	V70__fix_allele_freq_view.sql	-957778206	cpic	2024-10-03 15:13:15.938037	9	t
74	71	fix guideline summary view	SQL	V71__fix_guideline_summary_view.sql	-1334280856	cpic	2025-03-07 16:21:39.906989	8	t
75	72	gene cds changelog	SQL	V72__gene_cds_changelog.sql	1161542228	cpic	2025-08-13 13:08:11.731509	7	t
76	73	clinpgx guideline update	SQL	V73__clinpgx_guideline_update.sql	-1024347267	cpic	2025-08-13 13:08:11.764363	15	t
77	74	supplemental file cleanup	SQL	V74__supplemental_file_cleanup.sql	822347170	cpic	2025-08-21 13:23:06.297301	15	t
78	75	hydrazaline guideline	SQL	V75__hydrazaline_guideline.sql	1311712376	cpic	2025-09-08 15:29:54.084279	6	t
79	76	rename summary level	SQL	V76__rename_summary_level.sql	-1125398572	cpic	2026-03-13 12:58:42.488466	8	t
80	77	pharmgkb rename	SQL	V77__pharmgkb_rename.sql	1687555689	cpic	2026-03-13 12:58:42.52321	13	t
\.


--
-- Data for Name: gene; Type: TABLE DATA; Schema: cpic; Owner: -
--

COPY cpic.gene (symbol, chr, genesequenceid, proteinsequenceid, chromosequenceid, mrnasequenceid, hgncid, ncbiid, ensemblid, clinpgxid, frequencymethods, lookupmethod, version, notesondiplotype, url, functionmethods, notesonallelenaming, includephenotypefrequencies, includediplotypefrequencies) FROM stdin;
DRD2	chr11	NG_008841	NP_000786	\N	\N	HGNC:3023	1813	ENSG00000149295	PA27478	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
ATIC	chr2	NG_013002	NP_004035	\N	\N	HGNC:794	471	ENSG00000138363	PA25094	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
APOE	chr19	NG_007084	NP_000032	\N	\N	HGNC:613	348	ENSG00000130203	PA55	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
GSTM1	chr1	NG_009246	NP_000552	\N	\N	HGNC:4632	2944	ENSG00000134184	PA182	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
F5	chr1	NG_011806	NP_000121	\N	\N	HGNC:3542	2153	ENSG00000198734	PA159	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
CYB5R3	chr22	NG_012194	NP_000389	\N	\N	HGNC:2873	1727	ENSG00000100243	PA27331	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
PRKCA	chr17	NG_012206	NP_002728	\N	\N	HGNC:9393	5578	ENSG00000154229	PA33759	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
CHRNA3	chr15	NG_016143	NP_000734	\N	\N	HGNC:1957	1136	ENSG00000080644	PA113	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
HMGCR	chr5	NG_011449	NP_000850	\N	\N	HGNC:5006	3156	ENSG00000113161	PA189	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
CRHR1	chr17	NG_009902	NP_004373	\N	\N	HGNC:2357	1394	ENSG00000120088	PA26874	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
ADRB2	chr5	NG_016421	NP_000015	\N	\N	HGNC:286	154	ENSG00000169252	PA39	\N	PHENOTYPE	4	\N	https://cpicpgx.org/gene/adrb2/	\N	\N	t	t
ADRA2C	\N	\N	\N	\N	\N	HGNC:283	152	ENSG00000184160	\N	\N	PHENOTYPE	24	\N	https://cpicpgx.org/gene/adra2c/	\N	\N	t	t
ERCC1	chr19	NG_015839	NP_001974	\N	\N	HGNC:3433	2067	ENSG00000012061	PA155	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
POLG	chr15	NG_008218	NP_002684	\N	\N	HGNC:9179	5428	ENSG00000140521	PA33500	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
ASS1	chr9	NG_011542	NP_000041	\N	\N	HGNC:758	445	ENSG00000130707	PA162376926	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
ITPA	chr20	NG_012093	NP_258412	\N	\N	HGNC:6176	3704	ENSG00000125877	PA29973	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
MC4R	chr18	NG_016441	NP_005903	\N	\N	HGNC:6932	4160	ENSG00000166603	PA30676	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
COQ2	chr4	NG_015825	NP_056512	\N	\N	HGNC:25223	27235	ENSG00000173085	PA142672084	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
HTR2C	chrX	NG_012082	NP_000859	\N	\N	HGNC:5295	3358	ENSG00000147246	PA194	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
OTC	chrX	NG_008471	NP_000522	\N	\N	HGNC:8512	5009	ENSG00000036473	PA32840	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
MTRR	chr5	NG_008856	NP_002445	\N	\N	HGNC:7473	4552	ENSG00000124275	PA31277	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
LPA	chr6	NG_016147	NP_005568	\N	\N	HGNC:6667	4018	ENSG00000198670	PA30432	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
NAT1	chr8	NG_012245	NP_000653	\N	\N	HGNC:7645	9	ENSG00000171428	PA17	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
CPS1	chr2	NG_008285	NP_001866	\N	\N	HGNC:2323	1373	ENSG00000021826	PA26840	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
EGF	chr4	NG_011441	NP_001954	\N	\N	HGNC:3229	1950	ENSG00000138798	PA27664	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
DYNC2H1	chr11	NG_016423	NP_001368	\N	\N	HGNC:2962	79659	ENSG00000187240	PA27433	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
GNB3	chr12	NG_009100	NP_002066	\N	\N	HGNC:4400	2784	ENSG00000111664	PA176	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
SEMA3C	chr7	\N	NP_006370	\N	\N	HGNC:10725	10512	ENSG00000075223	PA35647	\N	PHENOTYPE	4	\N	\N	\N	\N	t	t
KIF6	chr6	\N	NP_659464	\N	\N	HGNC:21202	221458	ENSG00000164627	PA134920075	\N	PHENOTYPE	4	\N	\N	\N	\N	t	t
CCHCR1	chr6	\N	NP_061925	\N	\N	HGNC:13930	54535	ENSG00000204536	PA134942738	\N	PHENOTYPE	4	\N	\N	\N	\N	t	t
FCGR3A	chr1	NG_009066	NP_000560	\N	\N	HGNC:3619	2214	ENSG00000203747	PA28065	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
NAGS	chr17	NG_008106	NP_694551	\N	\N	HGNC:17996	162417	ENSG00000161653	PA134968729	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
LDLR	chr19	NG_009060	NP_000518	\N	\N	HGNC:6547	3949	ENSG00000130164	PA227	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
ASL	chr7	NG_009288	NP_000039	\N	\N	HGNC:746	435	ENSG00000126522	PA25046	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
HPRT1	chrX	NG_012329	NP_000185	\N	\N	HGNC:5157	3251	ENSG00000165704	PA29427	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
ANKK1	chr11	NG_012976	NP_848605	\N	\N	HGNC:21027	255239	ENSG00000170209	PA134872551	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
XPC	chr3	NG_011763	NP_004619	\N	\N	HGNC:12816	7508	ENSG00000154767	PA37413	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
FKBP5	chr6	NG_012645	NP_004108	\N	\N	HGNC:3721	2289	ENSG00000096060	PA28162	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
ACE	chr17	NG_011648	NP_000780	\N	\N	HGNC:2707	1636	ENSG00000159640	PA139	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
TXNRD2	chr22	NG_011835	NP_006431	\N	\N	HGNC:18155	10587	ENSG00000184470	PA38302	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
GBA	chr1	NG_009783	NP_000148	\N	\N	HGNC:4177	2629	ENSG00000177628	PA28591	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
HLA-DRB1	chr6	NG_002392	NP_002115	\N	\N	HGNC:4948	3123	ENSG00000196126	PA35072	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
CETP	chr16	NG_008952	NP_000069	\N	\N	HGNC:1869	1071	ENSG00000087237	PA108	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
UGT1A4	chr2	NG_002601	NP_009051	\N	\N	HGNC:12536	54657	ENSG00000244474	PA37179	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
TP53	chr17	NG_017013	NP_000537	\N	\N	HGNC:11998	7157	ENSG00000141510	PA36679	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
CALU	chr7	\N	NP_001210	\N	\N	HGNC:1458	813	ENSG00000128595	\N	\N	PHENOTYPE	112	\N	\N	\N	\N	t	t
CES1	chr16	NG_012057	NP_001257	\N	\N	HGNC:1863	1066	ENSG00000198848	\N	\N	PHENOTYPE	111	\N	\N	\N	\N	t	t
TCF7L2	chr10	NG_012631	NP_110383	\N	\N	HGNC:11641	6934	ENSG00000148737	PA36394	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
ADD1	chr4	NG_012037	NP_001110	\N	\N	HGNC:243	118	ENSG00000087274	PA31	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
TMEM43	chr3	NG_008975	NP_077310	\N	\N	HGNC:28472	79188	ENSG00000170876	PA134871907	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
SOD2	chr6	NG_008729	NP_000627	\N	\N	HGNC:11180	6648	ENSG00000112096	PA36017	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
NAT2	chr8	NG_012246.1	NP_000006.2	NC_000008.11	NM_001042351.2	HGNC:7646	10	ENSG00000156006	\N	\N	PHENOTYPE	133	\N	\N	\N	Common name	t	t
SERPINC1	chr1	NG_012462	NP_000479	\N	\N	HGNC:775	462	ENSG00000117601	PA35026	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
ADRB1	\N	\N	\N	\N	\N	HGNC:285	153	ENSG00000043591	\N	\N	PHENOTYPE	110	\N	https://cpicpgx.org/gene/adrb1/	\N	\N	t	t
TNF	chr6	NG_007462	NP_000585	\N	\N	HGNC:11892	7124	ENSG00000232810	PA435	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
C11orf65	chr11	\N	NP_689800	\N	\N	HGNC:28519	160140	ENSG00000166323	PA144596484	\N	PHENOTYPE	4	\N	\N	\N	\N	t	t
HAS3	chr16	\N	NP_005320	\N	\N	HGNC:4820	3038	ENSG00000103044	PA29196	\N	PHENOTYPE	4	\N	\N	\N	\N	t	t
SLC47A2	chr17	\N	NP_001093116	\N	\N	HGNC:26439	146802	ENSG00000180638	PA162403847	\N	PHENOTYPE	4	\N	\N	\N	\N	t	t
CBR3	chr21	\N	NP_001227	\N	\N	HGNC:1549	874	ENSG00000159231	PA26122	\N	PHENOTYPE	4	\N	\N	\N	\N	t	t
NT5C2	chr10	\N	NP_036361	\N	\N	HGNC:8022	22978	ENSG00000076685	PA31801	\N	PHENOTYPE	4	\N	\N	\N	\N	t	t
NEDD4L	chr18	\N	NP_056092	\N	\N	HGNC:7728	23327	ENSG00000049759	PA31534	\N	PHENOTYPE	4	\N	\N	\N	\N	t	t
CYB5R1	chr1	\N	NP_057327	\N	\N	HGNC:13397	51706	ENSG00000159348	PA134979668	\N	PHENOTYPE	4	\N	\N	\N	\N	t	t
SLC28A3	chr9	\N	NP_071410	\N	\N	HGNC:16484	64078	ENSG00000197506	PA426	\N	PHENOTYPE	4	\N	\N	\N	\N	t	t
CYP2A7P1	chr19	NG_000008	\N	\N	\N	HGNC:2612	1550	ENSG00000213908	\N	\N	PHENOTYPE	112	\N	\N	\N	\N	t	t
FDPS	chr1	\N	NP_001995	\N	\N	HGNC:3631	2224	ENSG00000160752	PA28075	\N	PHENOTYPE	4	\N	\N	\N	\N	t	t
PTGFR	chr1	\N	NP_000950	\N	\N	HGNC:9600	5737	ENSG00000122420	PA290	\N	PHENOTYPE	4	\N	\N	\N	\N	t	t
KCNIP4	chr4	\N	NP_671711	\N	\N	HGNC:30083	80333	ENSG00000185774	PA134893552	\N	PHENOTYPE	4	\N	\N	\N	\N	t	t
HLA-DQA1	chr6	\N	NP_002113	\N	\N	HGNC:4942	3117	ENSG00000196735	PA35066	\N	PHENOTYPE	4	\N	\N	\N	\N	t	t
ABCC4	chr13	\N	NP_005836	\N	\N	HGNC:55	10257	ENSG00000125257	PA397	\N	PHENOTYPE	4	\N	\N	\N	\N	t	t
ABL2	chr1	\N	NP_005149	\N	\N	HGNC:77	27	ENSG00000143322	PA24414	\N	PHENOTYPE	4	\N	\N	\N	\N	t	t
UGT2B15	chr4	\N	NP_001067	\N	\N	HGNC:12546	7366	ENSG00000196620	PA37188	\N	PHENOTYPE	4	\N	\N	\N	\N	t	t
YEATS4	chr12	\N	NP_006521	\N	\N	HGNC:24859	8089	ENSG00000127337	PA134992686	\N	PHENOTYPE	4	\N	\N	\N	\N	t	t
TANC1	chr2	\N	NP_203752	\N	\N	HGNC:29364	85461	ENSG00000115183	PA142670838	\N	PHENOTYPE	4	\N	\N	\N	\N	t	t
CRHR2	chr7	\N	NP_001874	\N	\N	HGNC:2358	1395	ENSG00000106113	PA26875	\N	PHENOTYPE	4	\N	\N	\N	\N	t	t
CYB5R2	chr11	\N	NP_057313	\N	\N	HGNC:24376	51700	ENSG00000166394	PA142672060	\N	PHENOTYPE	4	\N	\N	\N	\N	t	t
XRCC1	chr19	\N	NP_006288	\N	\N	HGNC:12828	7515	ENSG00000073050	PA369	\N	PHENOTYPE	4	\N	\N	\N	\N	t	t
COL22A1	chr8	\N	NP_690848	\N	\N	HGNC:22989	169044	ENSG00000169436	PA134914705	\N	PHENOTYPE	4	\N	\N	\N	\N	t	t
CYB5R4	chr6	\N	NP_057314	\N	\N	HGNC:20147	51167	ENSG00000065615	PA134904907	\N	PHENOTYPE	4	\N	\N	\N	\N	t	t
C8orf34	chr8	\N	NP_443190	\N	\N	HGNC:30905	116328	ENSG00000165084	PA142672353	\N	PHENOTYPE	4	\N	\N	\N	\N	t	t
ADORA2A	chr22	\N	NP_000666	\N	\N	HGNC:263	135	ENSG00000128271	PA24584	\N	PHENOTYPE	4	\N	\N	\N	\N	t	t
FLOT1	chr6	\N	NP_005794	\N	\N	HGNC:3757	10211	ENSG00000137312	\N	\N	PHENOTYPE	112	\N	\N	\N	\N	t	t
GRIK4	chr11	\N	NP_055434	\N	\N	HGNC:4582	2900	ENSG00000149403	\N	\N	PHENOTYPE	112	\N	\N	\N	\N	t	t
GRK4	\N	\N	\N	\N	\N	HGNC:4543	2868	ENSG00000125388	\N	\N	PHENOTYPE	24	\N	https://cpicpgx.org/gene/grk4/	\N	\N	t	t
GRK5	\N	\N	\N	\N	\N	HGNC:4544	2869	ENSG00000198873	\N	\N	PHENOTYPE	110	\N	https://cpicpgx.org/gene/grk5/	\N	\N	t	t
HLA-C	chr6	NG_002397	NP_002108	\N	\N	HGNC:4933	3107	ENSG00000204525	\N	\N	PHENOTYPE	111	\N	\N	\N	\N	t	t
HLA-DPB1	chr6	\N	NP_002112	\N	\N	HGNC:4940	3115	ENSG00000223865	\N	\N	PHENOTYPE	112	\N	\N	\N	\N	t	t
HTR1A	chr5	\N	NP_000515	\N	\N	HGNC:5286	3350	ENSG00000178394	\N	\N	PHENOTYPE	112	\N	\N	\N	\N	t	t
IFNL4	chr19	\N	\N	\N	\N	HGNC:44480	101180976	ENSG00000272395	\N	\N	PHENOTYPE	114	\N	https://cpicpgx.org/gene/ifnl/	\N	\N	t	t
LTC4S	chr5	\N	NP_665874	\N	\N	HGNC:6719	4056	ENSG00000213316	\N	\N	PHENOTYPE	112	\N	\N	\N	\N	t	t
OPRM1	chr6	NG_021208	NP_000905	\N	\N	HGNC:8156	4988	ENSG00000112038	\N	\N	PHENOTYPE	105	\N	https://cpicpgx.org/gene/oprm1/	\N	\N	t	t
PTGS1	chr9	\N	NP_000953	\N	\N	HGNC:9604	5742	ENSG00000095303	\N	\N	PHENOTYPE	112	\N	\N	\N	\N	t	t
DPYD	chr1	NG_008807.2	NP_000101.2	NC_000001.11	NM_000110.4	HGNC:3012	282617	ENSG00000188641	\N	Methods:\nThe DPYD frequency table was created using data from ExAC (http://exac.broadinstitute.org/) and the 1000 Genomes project (http://www.ensembl.org/Homo_sapiens/Info/Index).\nThe average allele frequencies by race were calculated by taking the number with the variant in all studies divided by the total number of individuals tested for the variant in all studies.\nAll nucleotide changes are according to reference sequence NM_000110.3 and all protein changes are according to reference sequence NP_000101.2\nCaveats\nIf 1000 Genomes and/or ExAC did not return any frequency data for a given variant, cells were left blank\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details can be found at https://www.pharmgkb.org/page/biogeographicalGroups. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.\n\n\n\n\n\n\n\n	ACTIVITY_SCORE	437	The DPYD phenotype is assigned using a gene activity score (DPYD-AS; based on the DPYD Allele Functionality Table), calculated as the sum of the two DPYD variants with the lowest variant activity value. Briefly, carriers of two no function variants (DPYD-AS: 0) OR one decreased function variant (DPD-AS: 0.5) are classified as DPYD poor metabolizers; carriers of two decreased function variants OR carriers of only one no function variant (DPYD-AS: 1) OR carriers of only one decreased function variant (DPYD-AS: 1.5) are considered DPYD intermediate metabolizers , and those with only normal function variants are classified as DPYD normal metabolizers (DPYD-AS: 2). If two decreased/no function variants are present, each decreased/no function variant is considered to be on a different gene copy. Irrespective of the presence of decreased/no function variants, patients may carry multiple normal function variants. As an individual only carries a maximum of two fully functional DPYD copies, common normal function variants may be located on the same gene copy as other normal function variants or decreased/no function variants.	https://cpicpgx.org/gene/dpyd/	\N	Legacy Name/Class	f	f
HLA-A	chr6	NG_002398	NP_002107	\N	\N	HGNC:4931	3105	ENSG00000206503	\N	Methods\n\nThe allele frequency table was made by searching the PubMed® database (1995 to September 2019). The following criteria were used for HLA-A: (HLA-A) AND (allele OR frequency). In addition, reports were also identified from citations by others or review articles. Studies were considered for inclusion in the HLA-A frequency table if: (1) the ethnicity of the population was clearly indicated, (2) either allele frequencies or genotype frequencies were reported, (3) the method by which the genes were genotyped was indicated, (4) the sample population consisted of at least 50 individuals with a few exceptions (e.g., smaller cohorts that were part of larger studies) and (5) the study represented an original publication (no reviews or meta-analyses). Allele frequencies reported in phase 3 1000 Genomes (http://browser.1000genomes.org/index.html) and from allelefrequencies.net (https://www.allelefrequencies.net) were also included .\nCaveats to estimated allele frequencies:\n\nSampling. Allele frequencies collected by CPIC for the supplemental tables are based on published literature reports which typically study small groups of people based on a geographic location (e.g. Malaysia, Berlin, Cairo). Almost no studies use genetic markers to estimate ancestry. Manuscripts are often focused on a specific phenotype (e.g. disease) or study only individuals taking a particular drug. Such samples would not be considered a random sample of the general population. Another consideration is that sample size is important, and PGx studies are typically not large. The frequencies collected from these studies are then used to estimate general estimates of entire ethnic population allele frequencies. Therefore, frequencies from larger groups of subjects and frequencies averaged from many sample populations probably result in better estimates.\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details, including the definitions of each group, can be found at https://www.pharmgkb.org/page/biogeographicalGroups. We strongly recommend that users use either the publication or the PharmGKB link provided to familiarize themselves with the grouping system before using these allele frequencies. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.	ALLELE_STATUS	218	\N	https://cpicpgx.org/gene/hla/	\N	\N	f	f
NUDT15	chr13	NG_047021.1	NP_060753.1	NC_000013.11	NM_001042351.2	HGNC:23063	55270	ENSG00000136159	\N	The allele frequency table was made by searching the PubMed® database (no start date to 1/2018). Allele frequencies reported in the gnomAD browser (http://gnomad.broadinstitute.org/ - exomes and genomes) and ensembl (grch37.ensembl.org - exomes or genomes) were also included. URLs are included in the "PMID" column.\n\nDiplotype and phenotype frequencies were estimated using the equation describing Hardy Weinberg equilibrium based on reported allele frequencies.\n\nCaveats to estimated allele, diplotype and phenotype frequencies:\n\nSampling. Allele frequencies collected by CPIC for the supplemental tables are based on published literature reports which typically study small groups of people based on a geographic location (e.g. Malaysia, Berlin, Cairo). Almost no studies use genetic markers to estimate ancestry. Manuscripts are often focused on a specific phenotype (e.g. disease) or study only individuals taking a particular drug. Such samples would not be considered a random sample of the general population. Another consideration is that sample size is important, and PGx studies are typically not large. The frequencies collected from these studies are then used to estimate general estimates of entire ethnic population allele frequencies. Therefore, frequencies from larger groups of subjects and frequencies averaged from many sample populations probably result in better estimates.\n\nEstimation of *1 frequency. In general, there are no population studies that test for all known variant alleles. Because *1 is not genotyped directly in many studies, all alleles that are negative for a sequence variation are defaulted to a *1 assignment. The inferred frequency for *1 is estimated as: 100 - (sum of averaged variant allele frequencies). For genes where many alleles are not tested for in any population, and frequency of 'common' alleles is not well documented in many understudied populations (Oceania, South Asian, Latino), the *1 frequency will deviate even more from true values.\n\nDiplotype/Phenotype frequency estimates. Diplotype and phenotype frequencies were estimated using the equation describing Hardy Weinberg equilibrium based on reported allele frequencies. When calculating diplotype frequencies from these allele frequencies, the margin of error is compounded based on the margin of error on each allele in the diplotype. So, the margin of error will necessarily increase for diplotype frequency estimates compared to allele frequency estimates. For allele frequencies with already large margins of error due to small and non-random sampling, the diplotype margin of error could potentially be quite large. On the other hand, for well-studied alleles, the margin of error is likely low.\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details can be found at https://www.pharmgkb.org/page/biogeographicalGroups. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.	PHENOTYPE	428	\N	https://cpicpgx.org/gene/nudt15/	\N	Common name	t	t
ABCB1	chr7	NG_011513	NP_000918	\N	\N	HGNC:40	5243	ENSG00000085563	\N	\N	PHENOTYPE	111	\N	\N	\N	\N	t	t
MT-RNR1	chrM	NG_042193.1	NP_000101.2	NC_012920.1	NM_001042351.2	HGNC:7470	4549	ENSG00000211459	\N	Methods\n\nThe allele frequency table was made by searching the PubMed® database (1995 to September 2019). The following criteria were used for MT-RNR1: (Mitochondrial AND (A1555G OR C1494T OR T1095C) AND frequency). In addition, reports were also identified from citations by others or review articles. Studies were considered for inclusion in the MT-RNR1 frequency table if: (1) the ethnicity of the population was clearly indicated, (2) the method by which the genes were genotyped was indicated, (3) the sample population consisted of at least 50 individuals with a few exceptions (e.g., smaller cohorts that were part of larger studies) and (4) the study represented an original publication (no reviews or meta-analyses). Homoplasmic allele frequencies reported in gnomAD (https://gnomad.broadinstitute.org/) were also included .\nCaveats to estimated allele, diplotype and phenotype frequencies:\n\nSampling. Allele frequencies collected by CPIC for the supplemental tables are based on published literature reports which typically study small groups of people based on a geographic location (e.g. Malaysia, Berlin, Cairo). Almost no studies use genetic markers to estimate ancestry. Manuscripts are often focused on a specific phenotype (e.g. disease) or study only individuals taking a particular drug. Such samples would not be considered a random sample of the general population. Another consideration is that sample size is important, and PGx studies are typically not large. The frequencies collected from these studies are then used to estimate general estimates of entire ethnic population allele frequencies. Therefore, frequencies from larger groups of subjects and frequencies averaged from many sample populations probably result in better estimates.\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details, including the definitions of each group, can be found at https://www.pharmgkb.org/page/biogeographicalGroups. We strongly recommend that users use either the publication or the PharmGKB link provided to familiarize themselves with the grouping system before using these allele frequencies. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.	PHENOTYPE	392	\N	https://cpicpgx.org/gene/mt-rnr1/	\N	Common name	f	f
RYR1	chr19	NG_008866.1	NP_000531.2	NC_000019.10	NM_000540.2	HGNC:10483	6261	ENSG00000196218	\N	Methods\n\nTable includes variants based on an update of the CPIC guideline for potent volatile anesthetic agents and succinylcholine. The guideline update includes the published list of RYR1 variants (supplemental table S2), which are evaluated by the ClinGen malignant hyperthermia susceptibility (MHS) variant curation expert panel and classified for RYR1-related malignant hyperthermia susceptibility based on specified ACMG/AMP criteria (PMID 35849058).\n\ngnomAD v2.1.1 was queried with the variant positions or rsIDs.\ngnomAD population description - PharmGKB biogeographical group mapping:\nAfrican/African American - Sub-Saharan African\nSouth Asian - Central/South Asian\nLatino/Admixed American - Latino\nEast Asian - East Asian\nNon-Finnish European - European\nAshkenazi Jewish - Near Eastern\n\nCaveats to estimated allele, frequencies:\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details, including the definitions of each group, can be found at https://www.pharmgkb.org/page/biogeographicalGroups. We strongly recommend that users use either the publication or the PharmGKB link provided to familiarize themselves with the grouping system before using these allele frequencies. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.	PHENOTYPE	428	\N	https://cpicpgx.org/gene/ryr1/	\N	Common name	f	f
CYP4F2	chr19	NG_007971.2	NP_001073.3	NC_000019.10	NM_000069.2	HGNC:2645	8529	ENSG00000186115	\N	Methods\n\nThe allele frequency table was made by searching the PubMed® database (1995 to 2016). Allele frequencies reported in and gnomD browser and phase 3 1000 Genomes were also included (https://gnomad.broadinstitute.org/, http://browser.1000genomes.org/index.html) for alleles that contain single unique variant.\n\nCaveats to estimated allele, diplotype and phenotype frequencies:\n\nSampling. Allele frequencies collected by CPIC for the supplemental tables are based on published literature reports which typically study small groups of people based on a geographic location (e.g. Malaysia, Berlin, Cairo). Almost no studies use genetic markers to estimate ancestry. Manuscripts are often focused on a specific phenotype (e.g. disease) or study only individuals taking a particular drug. Such samples would not be considered a random sample of the general population. Another consideration is that sample size is important, and PGx studies are typically not large. The frequencies collected from these studies are then used to estimate general estimates of entire ethnic population allele frequencies. Therefore, frequencies from larger groups of subjects and frequencies averaged from many sample populations probably result in better estimates.\n\nEstimation of *1 frequency. In general, there are no population studies that test for all known variant alleles. Because *1 is not genotyped directly in many studies, all alleles that are negative for a sequence variation are defaulted to a *1 assignment. Because CYP4F2*1 is not genotyped directly, all alleles that are negative for a sequence variation are defaulted to a CYP4F2*1 assignment. Likewise, sequence variations of alleles that are not tested may default to a CYP4F2*1 assignment and hence contribute to the frequencies reported for this allele. Therefore, the inferred frequency for CYP4F2*1 was calculated as an average from studies describing allele frequencies for the most common alleles found in a particular biogeographical group.\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details can be found at https://www.pharmgkb.org/page/biogeographicalGroups. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.	PHENOTYPE	340	CYP4F2 diplotype to phenotype translation is not applicable to the warfarin guideline.	https://cpicpgx.org/gene/cyp4f2/	\N	Legacy Name/Class	f	f
BCHE	chr3	NG_009031	NP_000046	\N	\N	HGNC:983	590	ENSG00000114200	\N	\N	PHENOTYPE	111	\N	\N	\N	\N	t	t
TYMS	chr18	\N	NP_001062	\N	\N	HGNC:12441	7298	ENSG00000176890	\N	\N	PHENOTYPE	112	\N	\N	\N	\N	t	t
ABCG2	chr4	NG_032067.2	NP_001335914.1	NC_000004.12	NM_004827.3	HGNC:74	9429	ENSG00000118777	\N	Methods\n\nThe allele frequency table was made by searching the Genome Aggregation Database (gnomAD) and 1000 Genomes phase 3 data by rsID. In addition, pubmed were also searched to include frequencies for certain biogeographical groups (eg. Oceanian and American).\n\nCaveats to estimated allele, frequencies:\n\nSampling. Allele frequencies collected by CPIC for the supplemental tables are based on published literature reports which typically study small groups of people based on a geographic location (e.g. Malaysia, Berlin, Cairo). Almost no studies use genetic markers to estimate ancestry. Manuscripts are often focused on a specific phenotype (e.g. disease) or study only individuals taking a particular drug. Such samples would not be considered a random sample of the general population. Another consideration is that sample size is important, and PGx studies are typically not large. The frequencies collected from these studies are then used to estimate general estimates of entire ethnic population allele frequencies. Therefore, frequencies from larger groups of subjects and frequencies averaged from many sample populations probably result in better estimates.\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details, including the definitions of each group, can be found at https://www.pharmgkb.org/page/biogeographicalGroups. We strongly recommend that users use either the publication or the PharmGKB link provided to familiarize themselves with the grouping system before using these allele frequencies. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.	PHENOTYPE	335	\N	https://cpicpgx.org/gene/abcg2/	\N	\N	t	t
ACYP2	\N	\N	\N	\N	\N	HGNC:180	98	ENSG00000170634	\N	\N	PHENOTYPE	85	\N	\N	\N	\N	t	t
UMPS	chr3	NG_017037	NP_000364	\N	\N	HGNC:12563	7372	ENSG00000114491	\N	\N	PHENOTYPE	111	\N	\N	\N	\N	t	t
CFTR	chr7	NG_016465.4	NP_000483.3	NC_000007.14	NM_000069.2	HGNC:1884	1080	ENSG00000001626	\N	\N	PHENOTYPE	327	\N	https://cpicpgx.org/gene/cftr/	\N	Legacy Name/Class	t	t
CYP2C9	chr10	NG_008385.2	NP_000762.2	NC_000010.11	NM_000069.2	HGNC:2623	1559	ENSG00000138109	\N	Methods\n\nThe allele frequency table was made by searching the PubMed® database (1995 to July 2019). The following criteria were used for CYP2C9: (CYP2C9 or 2C9 or cytochrome P4502C9) AND (genotype OR allele OR frequency OR minor allele OR variant OR ethnic OR race OR racial OR ethnicity OR population) with filter limits set to retrieve "full-text" and "English" literature. In addition, reports were also identified from citations by others or review articles. Studies were considered for inclusion in the CYP2C9 frequency table if: (1) the ethnicity of the population was clearly indicated, (2) either allele frequencies or genotype frequencies were reported, (3) the method by which the genes were genotyped was indicated, (4) the sample population consisted of at least 50 individuals with a few exceptions (e.g., smaller cohorts that were part of larger studies) and (5) the study represented an original publication (no reviews or meta-analyses). Allele frequencies reported in and gnomD browser and phase 3 1000 Genomes were also included (https://gnomad.broadinstitute.org/, http://browser.1000genomes.org/index.html) for alleles that contain single unique variant.\n\nDiplotype and Phenotype Calculations. Diplotype and phenotype frequencies were estimated using the equation describing Hardy Weinberg equilibrium based on reported allele frequencies.\n\nCaveats to estimated allele, diplotype and phenotype frequencies:\n\nSampling. Allele frequencies collected by CPIC for the supplemental tables are based on published literature reports which typically study small groups of people based on a geographic location (e.g. Malaysia, Berlin, Cairo). Almost no studies use genetic markers to estimate ancestry. Manuscripts are often focused on a specific phenotype (e.g. disease) or study only individuals taking a particular drug. Such samples would not be considered a random sample of the general population. Another consideration is that sample size is important, and PGx studies are typically not large. The frequencies collected from these studies are then used to estimate general estimates of entire ethnic population allele frequencies. Therefore, frequencies from larger groups of subjects and frequencies averaged from many sample populations probably result in better estimates.\n\nEstimation of *1 frequency. In general, there are no population studies that test for all known variant alleles. Because *1 is not genotyped directly in many studies, all alleles that are negative for a sequence variation are defaulted to a *1 assignment. Because CYP2C9*1 is not genotyped directly, all alleles that are negative for a sequence variation are defaulted to a CYP2C9*1 assignment. Likewise, sequence variations of alleles that are not tested may default to a CYP2C9*1 assignment and hence contribute to the frequencies reported for this allele. Therefore, the inferred frequency for CYP2C9*1 was calculated as an average from studies describing allele frequencies for the most common alleles found in a particular biogeographical group.\n\nDiplotype/Phenotype frequency estimates. When calculating diplotype frequencies from these allele frequencies, the margin of error is compounded based on the margin of error on each allele in the diplotype. So, the margin of error will necessarily increase for diplotype frequency estimates compared to allele frequency estimates. For allele frequencies with already large margins of error due to small and non-random sampling, the diplotype margin of error could potentially be quite large. On the other hand, for well-studied alleles, the margin of error is likely low.\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details can be found at https://www.pharmgkb.org/page/biogeographicalGroups. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.	ACTIVITY_SCORE	439	CYP2C9 diplotype to phenotype translation is not applicable to the warfarin guideline.	https://cpicpgx.org/gene/cyp2c9/	Methods:\nThe PubMed and PharmGKB databases were searched for the following keywords: (CYP2C9 OR cytochrome p450 2c9)AND [genomic identifiers (e.g. dbSNP rs number, star alleles, additional common names)] AND English [Language]. Study inclusion criteria included publications that incorporated analyses for the association between CYP2C9 genotype and drug pharmacokinetic parameters, clinical outcomes, or allele function.	Legacy Name/Class	t	t
VDR	chr12	NG_008731	NP_000367	\N	\N	HGNC:12679	7421	ENSG00000111424	\N	\N	PHENOTYPE	111	\N	\N	\N	\N	t	t
UGT1A1	chr2	NG_002601.2	NP_000454.1	NC_000002.12	NM_000540.2	HGNC:12530	54658	ENSG00000241635	\N	Methods\n\nThe allele frequency table was made by searching the PubMed® database (1995 to 2015). Allele frequencies reported in phase 3 1000 Genomes were also included (http://browser.1000genomes.org/index.html).\n\nCaveats to estimated allele, diplotype and phenotype frequencies:\n\nSampling. Allele frequencies collected by CPIC for the supplemental tables are based on published literature reports which typically study small groups of people based on a geographic location (e.g. Malaysia, Berlin, Cairo). Almost no studies use genetic markers to estimate ancestry. Manuscripts are often focused on a specific phenotype (e.g. disease) or study only individuals taking a particular drug. Such samples would not be considered a random sample of the general population. Another consideration is that sample size is important, and PGx studies are typically not large. The frequencies collected from these studies are then used to estimate general estimates of entire ethnic population allele frequencies. Therefore, frequencies from larger groups of subjects and frequencies averaged from many sample populations probably result in better estimates.\n\nEstimation of *1 frequency. In general, there are no population studies that test for all known variant alleles. Because *1 is not genotyped directly in many studies, all alleles that are negative for a sequence variation are defaulted to a *1 assignment. Because UGT1A1*1 is not genotyped directly, all alleles that are negative for a sequence variation are defaulted to a UGT1A1*1 assignment. Likewise, sequence variations of alleles that are not tested may default to a UGT1A1*1 assignment and hence contribute to the frequencies reported for this allele. Therefore, the inferred frequency for UGT1A1*1 was calculated as an average from studies describing allele frequencies for the most common alleles found in a particular biogeographical group.\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details can be found at https://www.pharmgkb.org/page/biogeographicalGroups. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.	PHENOTYPE	428	\N	https://cpicpgx.org/gene/ugt1a1/	\N	Nucleotide changes from the UGT nomenclature page: https://www.pharmacogenomics.pha.ulaval.ca/wp-content/uploads/2015/04/UGT1A1-allele-nomenclature.html	f	f
COMT	chr22	NG_011526	NP_000745	\N	\N	HGNC:2228	1312	ENSG00000093010	\N	\N	PHENOTYPE	105	\N	https://cpicpgx.org/gene/comt/	\N	\N	t	t
CYP2C8	chr10	NG_007972	NP_000761	\N	\N	HGNC:2622	1558	ENSG00000138115	\N	\N	PHENOTYPE	111	\N	\N	\N	\N	t	t
CYP3A4	chr7	NG_000004	NP_059488	\N	\N	HGNC:2637	1576	ENSG00000160868	\N	\N	PHENOTYPE	111	\N	\N	\N	\N	t	t
CYP2D6	chr22	NG_008376.4	NP_000097.3	NC_000022.11	NM_000069.2	HGNC:2625	1565	ENSG00000100197	\N	Methods:\n\nThe CYP2D6 allele frequency tables (CYP2D6 frequency table; link to PharmGKB) are updates of those previously published in CPIC guidelines (PMID: 25974703, 24458010). Updates to the CYP2D6 allele frequency tables were made by searching the PubMed® database (1995 to 2018). The following criteria were used for CYP2D6: (CYP2D6 or 2D6 or cytochrome P4502D6) AND (genotype OR allele OR frequency OR minor allele OR variant OR ethnic OR race OR racial OR ethnicity) with filter limits set to retrieve "full-text" and "English" literature. In addition, reports were also identified from citations by others or review articles. Studies were considered for inclusion in the CYP2D6 frequency table if: (1) the ethnicity of the population was clearly indicated, (2) either allele frequencies or genotype frequencies were reported, (3) the method by which the genes were genotyped was indicated, (4) the sample population consisted of at least 50 individuals with a few exceptions (e.g., smaller cohorts that were part of larger studies) and (5) the study represented an original publication (no reviews or meta-analyses).\nDiplotype and phenotype frequencies were estimated using the equation describing Hardy Weinberg equilibrium based on reported allele frequencies. Because the frequencies for each allele are averages from all studies for that population, allele frequencies may not add up to100%. To account for this in diplotype and phenotype frequencies calculations, *1 frequency was calculated as 1 - sum (non *1 allele frequency).\n\n\nCaveats to estimated allele, diplotype and phenotype frequencies:\n\nSampling. Allele frequencies collected by CPIC for the supplemental tables are based on published literature reports which typically study small groups of people based on a geographic location (e.g. Malaysia, Berlin, Cairo). Almost no studies use genetic markers to estimate ancestry. Manuscripts are often focused on a specific phenotype (e.g. disease) or study only individuals taking a particular drug. Such samples would not be considered a random sample of the general population. Another consideration is that sample size is important, and PGx studies are typically not large. The frequencies collected from these studies are then used to estimate general estimates of entire ethnic population allele frequencies. Therefore, frequencies from larger groups of subjects and frequencies averaged from many sample populations probably result in better estimates.\n\nEstimation of *1 frequency. In general, there are no population studies that test for all known variant alleles. Because CYP2D6*1 is not genotyped directly, all alleles that are negative for a sequence variation are defaulted to a CYP2D6*1 assignment. Likewise, sequence variations of alleles that are not tested may default to a CYP2D6*1 assignment and hence contribute to the frequencies reported for this allele. Therefore, the inferred frequency for CYP2D6*1 was calculated as an average from studies describing allele frequencies for the most common alleles found in a particular ethnic group.\n\nDiplotype/Phenotype frequency estimates. When calculating diplotype frequencies from these allele frequencies, the margin of error is compounded based on the margin of error on each allele in the diplotype. So, the margin of error will necessarily increase for diplotype frequency estimates compared to allele frequency estimates. For allele frequencies with already large margins of error due to small and non-random sampling, the diplotype margin of error could potentially be quite large. On the other hand, for well-studied alleles, the margin of error is likely low.\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details, including the definitions of each group, can be found at https://www.pharmgkb.org/page/biogeographicalGroups. We strongly recommend that users use either the publication or the PharmGKB link provided to familiarize themselves with the grouping system before using these allele frequencies. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.\n\nOverestimation of allele frequencies. CYP2D6*2 is a 'default' assignment and, unless tested and discriminated for CYP2D6*8, *11, *17, *35,*41 and other variants, will default to a CYP2D6*2 assignment. The frequencies shown here may therefore be over-estimated. CYP2D6*10 is a 'default' assignment and, unless tested and discriminated for, CYP2D6*14 and *36 and other variants, will default to a CYP2D6*10 assignment. The frequencies shown here may therefore be over-estimated. CYP2D6*17 is a 'default' assignment and, unless tested and discriminated for, CYP2D6*40 and *58 will default to a CYP2D6*17 assignment. The frequencies shown here may therefore be over-estimated. CYP2D6*41 has not consistently been determined by its defining SNP (2988G>A) across studies; some platforms still use the -1584C>G SNP to discriminate between CYP2D6*2 and *41. This may lead to an overestimation of the CYP2D6*41 frequency, especially in those of African ancestry.\n\nCNV alleles. Many studies do not specify the exact copy number of duplicated alleles found in their study population and instead report the total frequency of observed CNVs as "xN". Where possible, these frequencies have been included in the CNV column for that allele (e.g. *1xN frequencies are included in the *1x2 column, *4xN frequencies are included in the *4x2 column). Users should be aware that this will lead to an overestimation of the frequency of that exact copy number in the population.	ACTIVITY_SCORE	434	\N	https://cpicpgx.org/gene/cyp2d6/	\N	Legacy Name/Class	t	t
HLA-B	chr6	NG_002397	NP_005505	\N	\N	HGNC:4932	3106	ENSG00000234745	\N	Methods\n\nThe allele frequency table was made by searching the PubMed® database (1995 to September 2019). The following criteria were used for HLA-B: (HLA-B) AND (allele OR frequency). In addition, reports were also identified from citations by others or review articles. Studies were considered for inclusion in the HLA-B frequency table if: (1) the ethnicity of the population was clearly indicated, (2) either allele frequencies or genotype frequencies were reported, (3) the method by which the genes were genotyped was indicated, (4) the sample population consisted of at least 50 individuals with a few exceptions (e.g., smaller cohorts that were part of larger studies) and (5) the study represented an original publication (no reviews or meta-analyses). Allele frequencies reported in phase 3 1000 Genomes (http://browser.1000genomes.org/index.html) and from allelefrequencies.net (https://www.allelefrequencies.net) were also included .\nCaveats to estimated allele, diplotype and phenotype frequencies:\n\nSampling. Allele frequencies collected by CPIC for the supplemental tables are based on published literature reports which typically study small groups of people based on a geographic location (e.g. Malaysia, Berlin, Cairo). Almost no studies use genetic markers to estimate ancestry. Manuscripts are often focused on a specific phenotype (e.g. disease) or study only individuals taking a particular drug. Such samples would not be considered a random sample of the general population. Another consideration is that sample size is important, and PGx studies are typically not large. The frequencies collected from these studies are then used to estimate general estimates of entire ethnic population allele frequencies. Therefore, frequencies from larger groups of subjects and frequencies averaged from many sample populations probably result in better estimates.\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details, including the definitions of each group, can be found at https://www.pharmgkb.org/page/biogeographicalGroups. We strongly recommend that users use either the publication or the PharmGKB link provided to familiarize themselves with the grouping system before using these allele frequencies. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.	ALLELE_STATUS	218	\N	https://cpicpgx.org/gene/hla/	\N	\N	f	f
EPHX1	chr1	NG_009776	NP_000111	\N	\N	HGNC:3401	2052	ENSG00000143819	\N	\N	PHENOTYPE	111	\N	\N	\N	\N	t	t
GGCX	chr2	NG_011811	NP_000812	\N	\N	HGNC:4247	2677	ENSG00000115486	\N	\N	PHENOTYPE	111	\N	\N	\N	\N	t	t
GP1BA	chr17	NG_008767	NP_000164	\N	\N	HGNC:4439	2811	ENSG00000185245	\N	\N	PHENOTYPE	111	\N	\N	\N	\N	t	t
GSTP1	chr11	NG_012075	NP_000843	\N	\N	HGNC:4638	2950	ENSG00000084207	\N	\N	PHENOTYPE	111	\N	\N	\N	\N	t	t
HTR2A	chr13	NG_013011	NP_000612	\N	\N	HGNC:5293	3356	ENSG00000102468	\N	\N	PHENOTYPE	111	\N	\N	\N	\N	t	t
MTHFR	chr1	NG_013351	NP_005948	\N	\N	HGNC:7436	4524	ENSG00000177000	\N	\N	PHENOTYPE	111	\N	\N	\N	\N	t	t
NQO1	chr16	NG_011504	NP_000894	\N	\N	HGNC:2874	1728	ENSG00000181019	\N	\N	PHENOTYPE	111	\N	\N	\N	\N	t	t
PROC	chr2	NG_016323	NP_000303	\N	\N	HGNC:9451	5624	ENSG00000115718	\N	\N	PHENOTYPE	111	\N	\N	\N	\N	t	t
PROS1	chr3	NG_009813	NP_000304	\N	\N	HGNC:9456	5627	ENSG00000184500	\N	\N	PHENOTYPE	111	\N	\N	\N	\N	t	t
SCN1A	chr2	NG_011906	NP_008851	\N	\N	HGNC:10585	6323	ENSG00000144285	\N	\N	PHENOTYPE	111	\N	\N	\N	\N	t	t
SLC6A4	chr17	NG_011747	NP_001036	\N	\N	HGNC:11050	6532	ENSG00000108576	\N	\N	PHENOTYPE	111	\N	\N	\N	\N	t	t
CYP3A5	chr7	NG_007938.2	NP_000768.1	NC_000007.14	NM_000069.2	HGNC:2638	1577	ENSG00000106258	\N	Methods\n\nThe allele frequency table was made by searching the PubMed® database (1995 to 2014).\n\nDiplotype and Phenotype Calculations. Diplotype and phenotype frequencies were estimated using the equation describing Hardy Weinberg equilibrium based on reported allele frequencies.\n\nCaveats to estimated allele frequencies:\n\nSampling. Allele frequencies collected by CPIC for the supplemental tables are based on published literature reports which typically study small groups of people based on a geographic location (e.g. Malaysia, Berlin, Cairo). Almost no studies use genetic markers to estimate ancestry. Manuscripts are often focused on a specific phenotype (e.g. disease) or study only individuals taking a particular drug. Such samples would not be considered a random sample of the general population. Another consideration is that sample size is important, and PGx studies are typically not large. The frequencies collected from these studies are then used to estimate general estimates of entire ethnic population allele frequencies. Therefore, frequencies from larger groups of subjects and frequencies averaged from many sample populations probably result in better estimates.\n\nEstimation of *1 frequency. In general, there are no population studies that test for all known variant alleles. Because *1 is not genotyped directly in many studies, all alleles that are negative for a sequence variation are defaulted to a *1 assignment. Because CYP3A5*1 is not genotyped directly, all alleles that are negative for a sequence variation are defaulted to a CYP3A5*1 assignment. Likewise, sequence variations of alleles that are not tested may default to a CYP3A5*1 assignment and hence contribute to the frequencies reported for this allele. Therefore, the inferred frequency for CYP3A5*1 was calculated as an average from studies describing allele frequencies for the most common alleles found in a particular biogeographical group.\n\nDiplotype/Phenotype frequency estimates. Diplotype and phenotype frequencies were estimated using the equation describing Hardy Weinberg equilibrium based on reported allele frequencies. When calculating diplotype frequencies from these allele frequencies, the margin of error is compounded based on the margin of error on each allele in the diplotype. So, the margin of error will necessarily increase for diplotype frequency estimates compared to allele frequency estimates. For allele frequencies with already large margins of error due to small and non-random sampling, the diplotype margin of error could potentially be quite large. On the other hand, for well-studied alleles, the margin of error is likely low.\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details, including the definitions of each group, can be found at https://www.pharmgkb.org/page/biogeographicalGroups. We strongly recommend that users use either the publication or the PharmGKB link provided to familiarize themselves with the grouping system before using these allele frequencies. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.\n	PHENOTYPE	433	\N	https://cpicpgx.org/gene/cyp3a5/	\N	Legacy Name/Class	t	t
SLCO1B1	chr12	NG_011745.1	NP_006437.3	NC_000012.12	NM_000540.2	HGNC:10959	10599	ENSG00000134538	\N	Methods\n\nThe allele frequency table was made by searching the PubMed® database (1995 to 2021).\n\nCaveats to estimated allele frequencies:\n\nSampling. Allele frequencies collected by CPIC for the supplemental tables are based on published literature reports which typically study small groups of people based on a geographic location (e.g. Malaysia, Berlin, Cairo). Almost no studies use genetic markers to estimate ancestry. Manuscripts are often focused on a specific phenotype (e.g. disease) or study only individuals taking a particular drug. Such samples would not be considered a random sample of the general population. Another consideration is that sample size is important, and PGx studies are typically not large. The frequencies collected from these studies are then used to estimate general estimates of entire ethnic population allele frequencies. Therefore, frequencies from larger groups of subjects and frequencies averaged from many sample populations probably result in better estimates.\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details can be found at https://www.pharmgkb.org/page/biogeographicalGroups. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.	PHENOTYPE	426	\N	https://cpicpgx.org/gene/slco1b1/	\N	Common name	t	t
CYP2C19	chr10	NG_008384.3	NP_000760.1	NC_000010.11	NM_000069.2	HGNC:2621	1557	ENSG00000165841	\N	Methods:\nThe CYP2C19 frequency table includes updates of those previously published in CPIC guidelines. Updates to the CYP2C19 frequency tables were made by searching the PubMed® database (1995 to 2015). The following criteria were used for CYP2C19: (CYP2C19 or 2C19 or cytochrome P4502C19) AND (genotype OR allele OR frequency OR minor allele OR variant OR ethnic OR race OR racial OR ethnicity) with filter limits set to retrieve "full-text" and "English" literature. In addition, reports were also identified from citations by others or review articles. Studies were considered for inclusion in the CYP2C19 frequency table if: (1) the ethnicity of the population was clearly indicated, (2) either allele frequencies or genotype frequencies were reported, (3) the method by which the genes were genotyped was indicated, (4) the sample population consisted of at least 50 individuals with a few exceptions (e.g., smaller cohorts that were part of larger studies) and (5) the study represented an original publication (no reviews or meta-analyses). Diplotype and phenotype frequencies were estimated using the equation describing Hardy Weinberg equilibrium based on reported allele frequencies.\n\nDiplotype and Phenotype Calculations. Diplotype and phenotype frequencies were estimated using the equation describing Hardy Weinberg equilibrium based on reported allele frequencies.\n\nCaveats to estimated allele, diplotype and phenotype frequencies:\n\nSampling. Allele frequencies collected by CPIC for the supplemental tables are based on published literature reports which typically study small groups of people based on a geographic location (e.g. Malaysia, Berlin, Cairo). Almost no studies use genetic markers to estimate ancestry. Manuscripts are often focused on a specific phenotype (e.g. disease) or study only individuals taking a particular drug. Such samples would not be considered a random sample of the general population. Another consideration is that sample size is important, and PGx studies are typically not large. The frequencies collected from these studies are then used to estimate general estimates of entire ethnic population allele frequencies. Therefore, frequencies from larger groups of subjects and frequencies averaged from many sample populations probably result in better estimates.\n\nEstimation of *1 frequency. In general, there are no population studies that test for all known variant alleles. Because *1 is not genotyped directly in many studies, all alleles that are negative for a sequence variation are defaulted to a *1 assignment. The inferred frequency for *1 is estimated as: 100 - (sum of averaged variant allele frequencies). For genes where many alleles are not tested for in any population, and frequency of 'common' alleles is not well documented in many understudied populations (Oceanian, Central/South Asian, Latino), the *1 frequency will deviate even more from true values.\n\nDiplotype/Phenotype frequency estimates. Diplotype and phenotype frequencies were estimated using the equation describing Hardy Weinberg equilibrium based on reported allele frequencies. When calculating diplotype frequencies from these allele frequencies, the margin of error is compounded based on the margin of error on each allele in the diplotype. So, the margin of error will necessarily increase for diplotype frequency estimates compared to allele frequency estimates. For allele frequencies with already large margins of error due to small and non-random sampling, the diplotype margin of error could potentially be quite large. On the other hand, for well-studied alleles, the margin of error is likely low.\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details, including the definitions of each group, can be found at https://www.pharmgkb.org/page/biogeographicalGroups. We strongly recommend that users use either the publication or the PharmGKB link provided to familiarize themselves with the grouping system before using these allele frequencies. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.	PHENOTYPE	437	\N	https://cpicpgx.org/gene/cyp2c19/	\N	Legacy Name/Class	t	t
IFNL3	chr19	NG_042193.1	NP_000101.2	NC_000019.10	NM_001042351.2	HGNC:18365	282617	ENSG00000197110	\N	\N	ALLELE_STATUS	229	\N	https://cpicpgx.org/gene/ifnl/	\N	Common Name	t	t
G6PD	chrX	NG_009015.2	NP_000101.2	NC_000023.11	NM_001042351.2	HGNC:4057	2539	ENSG00000160211	\N	Methods\n\nThe allele frequency table was made by searching the gnomAD database.\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details can be found at https://www.pharmgkb.org/page/biogeographicalGroups. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n	PHENOTYPE	382	\N	https://cpicpgx.org/gene/g6pd/	\N	Legacy Name/Class	f	f
TPMT	chr6	NG_012137.3	NP_000358.1	NC_000006.12	NM_000540.2	HGNC:12014	7172	ENSG00000137364	\N	The allele frequency table was made by searching the PubMed® database (no start date to 1/2018). Allele frequencies reported in the gnomAD browser (http://gnomad.broadinstitute.org/ - exomes and genomes) and ensembl (grch37.ensembl.org - exomes or genomes) were also included. URLs are included in the "PMID" column.\n\nDiplotype and Phenotype Calculations. Diplotype and phenotype frequencies were estimated using the equation describing Hardy Weinberg equilibrium based on reported allele frequencies.\n\nCaveats to estimated allele, diplotype and phenotype frequencies:\n\nSampling. Allele frequencies collected by CPIC for the supplemental tables are based on published literature reports which typically study small groups of people based on a geographic location (e.g. Malaysia, Berlin, Cairo). Almost no studies use genetic markers to estimate ancestry. Manuscripts are often focused on a specific phenotype (e.g. disease) or study only individuals taking a particular drug. Such samples would not be considered a random sample of the general population. Another consideration is that sample size is important, and PGx studies are typically not large. The frequencies collected from these studies are then used to estimate general estimates of entire ethnic population allele frequencies. Therefore, frequencies from larger groups of subjects and frequencies averaged from many sample populations probably result in better estimates.\n\nEstimation of *1 frequency. In general, there are no population studies that test for all known variant alleles. Because *1 is not genotyped directly in many studies, all alleles that are negative for a sequence variation are defaulted to a *1 assignment. The inferred frequency for *1 is estimated as: 100 - (sum of averaged variant allele frequencies). For genes where many alleles are not tested for in any population, and frequency of 'common' alleles is not well documented in many understudied populations (Oceania, South Asian, Latino), the *1 frequency will deviate even more from true values.\n\nDiplotype/Phenotype frequency estimates. Diplotype and phenotype frequencies were estimated using the equation describing Hardy Weinberg equilibrium based on reported allele frequencies. When calculating diplotype frequencies from these allele frequencies, the margin of error is compounded based on the margin of error on each allele in the diplotype. So, the margin of error will necessarily increase for diplotype frequency estimates compared to allele frequency estimates. For allele frequencies with already large margins of error due to small and non-random sampling, the diplotype margin of error could potentially be quite large. On the other hand, for well-studied alleles, the margin of error is likely low.\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details can be found at https://www.pharmgkb.org/page/biogeographicalGroups. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.	PHENOTYPE	426	\N	https://cpicpgx.org/gene/tpmt/	\N	Nucleotide change on cDNA from https://liu.se/en/research/tpmt-nomenclature-committee	t	t
CYP2B6	chr19	NG_007929.1	NP_000758.1	NC_000019.10	NM_000069.2	HGNC:2615	1555	ENSG00000197408	\N	Methods\n\nThe allele frequency table was made by searching the PubMed® database (no start date to May 2018). Studies were considered for inclusion in the CYP2B6 Frequency Table if (1) the ethnicity of the population was clearly indicated; (2) either allele frequencies or genotype frequencies were reported; and (3) the method by which genes were genotyped was indicated. Allele frequencies reported in the gnomAD browser (http://gnomad.broadinstitute.org/ - exomes and genomes) and 1000 Genomes Project phase 3 data on Ensemble browser (https://uswest.ensembl.org/index.html) were also included.\n\nDiplotype and Phenotype Calculations. Diplotype and phenotype frequencies were estimated using the equation describing Hardy Weinberg equilibrium based on reported allele frequencies.\n\nCaveats to estimated allele, diplotype and phenotype frequencies:\n\nSampling. Allele frequencies collected by CPIC for the supplemental tables are based on published literature reports which typically study small groups of people based on a geographic location (e.g. Malaysia, Berlin, Cairo). Almost no studies use genetic markers to estimate ancestry. Manuscripts are often focused on a specific phenotype (e.g. disease) or study only individuals taking a particular drug. Such samples would not be considered a random sample of the general population. Another consideration is that sample size is important, and PGx studies are typically not large. Studies were included in the frequency calculation regardless of number. The frequencies collected from these studies are then used to estimate general estimates of entire ethnic population allele frequencies. Therefore, frequencies from larger groups of subjects and frequencies averaged from many sample populations probably result in better estimates.\n\nEstimation of *1 frequency. In general, there are no population studies that test for all known variant alleles. Because *1 is not genotyped directly in many studies, all alleles that are negative for a sequence variation are defaulted to a *1 assignment. The inferred frequency for *1 is estimated as: 1 - (sum of averaged variant allele frequencies). For genes where many alleles are not tested for in any population, and frequency of 'common' alleles is not well documented in many understudied populations (Oceania, Middle eastern, South Asian, Latino), the *1 frequency will deviate even more from true values.\n\nDiplotype/Phenotype frequency estimates. Diplotype and phenotype frequencies were estimated using the equation describing Hardy Weinberg equilibrium based on reported allele frequencies. When calculating diplotype frequencies from these allele frequencies, the margin of error is compounded based on the margin of error on each allele in the diplotype. So, the margin of error will necessarily increase for diplotype frequency estimates compared to allele frequency estimates. For allele frequencies with already large margins of error due to small and non-random sampling, the diplotype margin of error could potentially be quite large. On the other hand, for well-studied alleles, the margin of error is likely low.\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details, including the definitions of each group, can be found at https://www.pharmgkb.org/page/biogeographicalGroups. We strongly recommend that users use either the publication or the PharmGKB link provided to familiarize themselves with the grouping system before using these allele frequencies. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.	PHENOTYPE	438	\N	https://cpicpgx.org/gene/cyp2b6/	\N	Legacy Name/Class	t	t
VKORC1	chr16	NG_011564.1	NP_076869.1	NC_000016.10	NM_000540.2	HGNC:23663	79001	ENSG00000167397	\N	Methods\n\nThe allele frequency table was made by searching the PubMed® database (1995 to 2016). Allele frequencies reported in phase 3 1000 Genomes were also included (http://browser.1000genomes.org/index.html).\n\nCaveats to estimated allele, diplotype and phenotype frequencies:\n\nSampling. Allele frequencies collected by CPIC for the supplemental tables are based on published literature reports which typically study small groups of people based on a geographic location (e.g. Malaysia, Berlin, Cairo). Almost no studies use genetic markers to estimate ancestry. Manuscripts are often focused on a specific phenotype (e.g. disease) or study only individuals taking a particular drug. Such samples would not be considered a random sample of the general population. Another consideration is that sample size is important, and PGx studies are typically not large. The frequencies collected from these studies are then used to estimate general estimates of entire ethnic population allele frequencies. Therefore, frequencies from larger groups of subjects and frequencies averaged from many sample populations probably result in better estimates.\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details can be found at https://www.pharmgkb.org/page/biogeographicalGroups. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.	PHENOTYPE	335	VKORC1 diplotype to phenotype translation is not applicable to the warfarin guideline.	https://cpicpgx.org/gene/vkorc1/	\N	Common Name	f	f
CACNA1S	chr1	NG_009816.1	NP_000060.2	NC_000001.11	NM_000069.2	HGNC:1397	779	ENSG00000081248	\N	Methods\n\nThe allele frequency table was made by searching the Genome Aggregation Database (gnomAD) by each rsID\n\nCaveats to estimated allele, frequencies:\n\nSampling. Allele frequencies collected by CPIC for the supplemental tables are based on published literature reports which typically study small groups of people based on a geographic location (e.g. Malaysia, Berlin, Cairo). Almost no studies use genetic markers to estimate ancestry. Manuscripts are often focused on a specific phenotype (e.g. disease) or study only individuals taking a particular drug. Such samples would not be considered a random sample of the general population. Another consideration is that sample size is important, and PGx studies are typically not large. The frequencies collected from these studies are then used to estimate general estimates of entire ethnic population allele frequencies. Therefore, frequencies from larger groups of subjects and frequencies averaged from many sample populations probably result in better estimates.\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details, including the definitions of each group, can be found at https://www.pharmgkb.org/page/biogeographicalGroups. We strongly recommend that users use either the publication or the PharmGKB link provided to familiarize themselves with the grouping system before using these allele frequencies. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.	PHENOTYPE	439	\N	https://cpicpgx.org/gene/cacna1s/	\N	\N	f	f
\.


--
-- Data for Name: gene_result; Type: TABLE DATA; Schema: cpic; Owner: -
--

COPY cpic.gene_result (id, genesymbol, result, activityscore, ehrpriority, consultationtext, version, frequency) FROM stdin;
7934352	RYR1	Malignant Hyperthermia Susceptibility	n/a	Abnormal/Priority/High Risk	This result signifies that this patient has one copy of a variant [variant] associated with malignant hyperthermia susceptibility. Halogenated volatile anesthetics or depolarizing muscle relaxants are relatively contraindicated in persons with MHS. They should not be used, except in extraordinary circumstances where the benefits outweigh the risks. Please consult a MHS specialist or contact MHAUS (https://www.mhaus.org/healthcare-professionals/) for further information.	2	\N
7902722	RYR1	Uncertain Susceptibility	n/a	Normal Risk	Variation in RYR1 and/or CACNA1S genes is associated with increased risk of Malignant hyperthermia after administration of depolarizing muscle relaxants and potent volatile anesthetics. Although listed causative RYR1 variants were NOT detected in this patient, it should be noted that this finding does not absolutely rule out the possibility of malignant hyperthermia. These results should be interpreted in the context of other genetic and clinical findings, family history and other laboratory data.	2	\N
7960735	SLCO1B1	Indeterminate	n/a	none	This result signifies that the patient has an allele combination with unknown or uncertain function alleles. The expected phenotype for this patient cannot be determined currently based on the SLCO1B1 diplotype result. Please consult a clinical pharmacist for more specific information about how SLCO1B1 function influences drug dosing.	3	{"American": 0.0, "European": 0.001279436, "Oceanian": 0.0, "East Asian": 0.007855513, "Near Eastern": 0.0, "Central/South Asian": 0.0005580649, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": 0.0}
7960705	SLCO1B1	Decreased Function	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a normal function allele (*_) and one copy of a no function allele (*_). Based on the genotype result, this patient is predicted to have decreased SLCO1B1 function. This patient may be at risk for an adverse response to medications that are affected by SLCO1B1. To avoid an untoward drug response, dose adjustments may be necessary for medications affected by SLCO1B1 (i.e. statins). Please consult a clinical pharmacist for more specific information about how SLCO1B1 function influences drug dosing.	3	{"American": 0.3648, "European": 0.28296122, "Oceanian": 0.0, "East Asian": 0.21842287, "Near Eastern": 0.32000002, "Central/South Asian": 0.12971397, "Sub-Saharan African": 0.054308295, "African American/Afro-Caribbean": 0.0198}
7960784	SLCO1B1	Poor Function	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has two copies of a no function allele. Based on the genotype result, this patient is predicted to have low SLCO1B1 function. This patient may be at a high risk for an adverse response to medications that are affected by SLCO1B1 (i.e. statins). To avoid an untoward drug response, dose adjustments or alternative therapeutic agents may be necessary for medications affected by SLCO1B1. Please consult a clinical pharmacist for more specific information about how SLCO1B1 function influences drug dosing.	3	{"American": 0.0576, "European": 0.02916489, "Oceanian": 0.0, "East Asian": 0.015759302, "Near Eastern": 0.040000003, "Central/South Asian": 0.004863923, "Sub-Saharan African": 0.0007803353, "African American/Afro-Caribbean": 0.00010}
7862607	CYP2D6	Ultrarapid Metabolizer	2.75	Abnormal/Priority/High Risk	This result signifies that this patient has [X copies of a normal function allele (*_xN)] [X copies of a decreased function allele (*_)] [X copies of a no function allele (*_)]. Based on the genotype result this patient is predicted to be an ultrarapid metabolizer of CYP2D6 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2D6. To avoid an untoward drug response, dose adjustments may be necessary for medications metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.0, "American": 0.0, "European": 0.0, "Oceanian": 0.0, "East Asian": 0.0, "Near Eastern": 0.0, "Central/South Asian": 0.0, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": 0.0}
7862713	CYP2D6	Ultrarapid Metabolizer	2.5	Abnormal/Priority/High Risk	This result signifies that this patient has [X copies of a normal function allele (*_xN)] [X copies of a decreased function allele (*_)]. Based on the genotype result this patient is predicted to be an ultrarapid metabolizer of CYP2D6 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2D6. To avoid an untoward drug response, dose adjustments may be necessary for medications metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.0022434974, "American": 0.0005345896, "European": 0.0003203256, "Oceanian": 0.00024761492, "East Asian": 0.00034846712, "Near Eastern": 0.005864233, "Central/South Asian": 0.00006554563, "Sub-Saharan African": 0.015329994, "African American/Afro-Caribbean": 0.01435911}
7863151	CYP2D6	Normal Metabolizer	1.5	Normal/Routine/ Low Risk	This result signifies that this patient has [1 copy of a normal function allele (*_)] [X copies of a decreased function allele (*_)] [X copies of a no function allele (*_)]. Based on the genotype result this patient is predicted to be a normal metabolizer of CYP2D6 substrates. There is no reason to selectively adjust the dose of most medications that are metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.051568672, "American": 0.012521543, "European": 0.010339902, "Oceanian": 0.00143701, "East Asian": 0.017062929, "Near Eastern": 0.045171212, "Central/South Asian": 0.0029989334, "Sub-Saharan African": 0.23161727, "African American/Afro-Caribbean": 0.23827769}
7961467	TPMT	Intermediate Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a normal function allele and one copy of a no function allele OR two copies of a decreased function allele. Based on the genotype result this patient is predicted to be a TPMT intermediate metabolizer. This patient may be at risk for an adverse reactions to medications that are metabolized by TPMT (eg. thiopurines). To avoid an untoward drug response, dose adjustments or alternative therapeutic agents may be necessary for medications metabolized by TPMT. However, thiopurines can be affected by a patient's TPMT and NUDT15 phenotype. Please consult a clinical pharmacist for more information about how TPMT and NUDT15 metabolic status influences drug selection and dosing.	3	{"Latino": 0.10125442, "European": 0.08729337, "East Asian": 0.039815668, "Near Eastern": 0.06641302, "Central/South Asian": 0.03638162, "Sub-Saharan African": 0.1010342, "African American/Afro-Caribbean": 0.06894094}
7961893	TPMT	Poor Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has two copies of a no function allele. Based on the genotype result this patient is predicted to be a TPMT poor metabolizer. This patient may be at a high risk for an adverse reactions to medications that are metabolized by TPMT (eg. thiopurines). To avoid an untoward drug response, dose adjustments or or alternative therapy may be necessary for medications metabolized by TPMT. However, thiopurines can be affected by a patient's TPMT and NUDT15 phenotype. Please consult a clinical pharmacist for more information about how TPMT and NUDT16 metabolic status influences drug selection and dosing.	3	{"Latino": 0.0028794738, "European": 0.0020956735, "East Asian": 0.00041297937, "Near Eastern": 0.0011826118, "Central/South Asian": 0.0003435882, "Sub-Saharan African": 0.002971174, "African American/Afro-Caribbean": 0.0013917874}
7962636	TPMT	Indeterminate	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a normal function allele and one copy of an uncertain or unknown function allele OR one copy of a decreased function allele and one copy of an uncertain or unknown function allele OR two copies of an uncertain or unknown function allele. The expected phenotype for this patient cannot be determined currently based on the TPMT diplotype result. Consider evaluating TPMT erythrocyte activity to assess TPMT phenotype. Erythrocyte TPMT activity test results can be falsely low at diagnosis of leukemia and is unreliable in the case of recent red blood cell transfusions. If thiopurines are required and TPMT status is unknown, monitor closely for toxicity. Please consult a clinical pharmacist for more specific information about how TPMT function influences drug dosing.	3	{"Latino": 0.0032013063, "European": 0.0013079308, "East Asian": 0.000104039, "Near Eastern": 0.0, "Central/South Asian": 0.0, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": 0.06207684}
7863187	CYP2D6	Intermediate Metabolizer	1.0	Abnormal/Priority/High Risk	This result signifies that this patient has [1 copy of a normal function allele (*_)] [X copies of a decreased function allele (*_)] [X copies of a no function allele (*_)]. Based on the genotype result this patient is predicted to be an intermediate metabolizer of CYP2D6 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2D6. To avoid an untoward drug response, dose adjustments may be necessary for medications metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.2278144, "American": 0.21460281, "European": 0.28533316, "Oceanian": 0.077126324, "East Asian": 0.070599586, "Near Eastern": 0.14959782, "Central/South Asian": 0.17827679, "Sub-Saharan African": 0.20079781, "African American/Afro-Caribbean": 0.2080644}
7862377	CYP2D6	Ultrarapid Metabolizer	≥6.0	Abnormal/Priority/High Risk	This result signifies that this patient has [X copies of a normal function allele (*_xN)] [X copies of a decreased function allele (*_)] [X copies of a no function allele (*_)]. Based on the genotype result this patient is predicted to be an ultrarapid metabolizer of CYP2D6 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2D6. To avoid an untoward drug response, dose adjustments may be necessary for medications metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.0000010000001, "American": 0.0000010000001, "European": 0.0000028470035, "Oceanian": 0.0, "East Asian": 0.0000010000001, "Near Eastern": 0.0, "Central/South Asian": 0.0, "Sub-Saharan African": 0.000025000001, "African American/Afro-Caribbean": 0.0}
7862382	CYP2D6	Ultrarapid Metabolizer	≥5.0	Abnormal/Priority/High Risk	This result signifies that this patient has [X copies of a normal function allele (*_xN)] [X copies of a decreased function allele (*_)] [X copies of a no function allele (*_)]. Based on the genotype result this patient is predicted to be an ultrarapid metabolizer of CYP2D6 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2D6. To avoid an untoward drug response, dose adjustments may be necessary for medications metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.000055729302, "American": 0.00006450697, "European": 0.000058472542, "Oceanian": 0.0, "East Asian": 0.000015887783, "Near Eastern": 0.0, "Central/South Asian": 0.0, "Sub-Saharan African": 0.00025361063, "African American/Afro-Caribbean": 0.0}
7962752	UGT1A1	Indeterminate	n/a	none	This result signifies that the patient has an allele combination with uncertain and/or unknown function alleles. The expected phenotype for this patient cannot be determined currently based on the UGT1A1 diplotype result. UGT1A1*80 is in very high linkage disequilibrium with *28 and *37. In the rare event that *80 is detected but *28 and *37 are not, there are not enough clinical data to predict metabolizer status with certainty. However, if only *80 is interrogated and the patient is heterozygous or homozygous for *80, an intermediate or poor metabolizer phenotype may be inferred, respectively. Please consult a clinical pharmacist for more specific information about how UGT1A1 function influences drug dosing.	2	\N
7962714	UGT1A1	Intermediate Metabolizer	n/a	Normal/Routine/Low Risk	This result signifies that the patient has one copy of a normal function allele (*1) OR one copy of an increased function allele (*36), AND and one copy of a decreased function allele (*_). Based on the genotype result this patient is predicted to be an intermediate metabolizer of UGT1A1 substrates. There is no reason to selectively adjust the dose of most medications that inhibit or are inactivated by UGT1A1. Please consult a clinical pharmacist for more information about how UGT1A1 metabolic status influences drug selection and dosing.	2	\N
7962707	UGT1A1	Normal Metabolizer	n/a	Normal/Routine/Low Risk	This result signifies that the patient has two copies of a normal function allele (*1) OR one copy of a normal function allele (*1) and one copy of an increased function allele (*36) OR two copies of an increased function allele (*36). Based on the genotype result this patient is predicted to be an normal metabolizer of UGT1A1 substrates. There is no reason to selectively adjust the dose of most medications that inhibit or are inactivated by UGT1A1. Please consult a clinical pharmacist for more information about how UGT1A1 metabolic status influences drug selection and dosing.	2	\N
7962729	UGT1A1	Poor Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has two copies of decreased function alleles (*_ and *_). Based on the genotype result this patient is predicted to be a poor metabolizer of UGT1A1 substrates. This patient may be at risk for an adverse or poor response to medications that inhibit or are inactivated by UGT1A1. Based on the genotype result, this patient is predicted to have low UGT1A1 function, which is generally indicative of Gilbert syndrome. This patient may be at high risk for toxicity from select medications that inhibit or are inactivated by UGT1A1. Please consult a clinical pharmacist for more information about how UGT1A1 metabolic status influences drug selection and dosing.	2	\N
7862462	CYP2D6	Ultrarapid Metabolizer	≥3.25	Abnormal/Priority/High Risk	This result signifies that this patient has [X copies of a normal function allele (*_xN)] [X copies of a decreased function allele (*_)] [X copies of a no function allele (*_)]. Based on the genotype result this patient is predicted to be an ultrarapid metabolizer of CYP2D6 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2D6. To avoid an untoward drug response, dose adjustments may be necessary for medications metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.00018561553, "American": 0.00009731066, "European": 0.00046782166, "Oceanian": 0.0, "East Asian": 0.0009120896, "Near Eastern": 0.0, "Central/South Asian": 0.0, "Sub-Saharan African": 0.000952962, "African American/Afro-Caribbean": 0.0}
7862584	CYP2D6	Ultrarapid Metabolizer	4.0	Abnormal/Priority/High Risk	This result signifies that this patient has [X copies of a normal function allele (*_xN)] [X copies of a decreased function allele (*_)] [X copies of a no function allele (*_)]. Based on the genotype result this patient is predicted to be an ultrarapid metabolizer of CYP2D6 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2D6. To avoid an untoward drug response, dose adjustments may be necessary for medications metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.0007764387, "American": 0.0010402872, "European": 0.0003002313, "Oceanian": 0.014133941, "East Asian": 0.000063105406, "Near Eastern": 0.0041771694, "Central/South Asian": 0.00016144973, "Sub-Saharan African": 0.0006431835, "African American/Afro-Caribbean": 0.0007742127}
7862793	CYP2D6	Normal Metabolizer	2.25	Normal/Routine/ Low Risk	This result signifies that this patient has two copies of a normal function allele (*_x2) and one copy of decreased function allele with an activity value of 0.25 (*_). Based on the genotype result this patient is predicted to be a normal metabolizer of CYP2D6 substrates. There is no reason to selectively adjust the dose of most medications that are metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.005172111, "American": 0.0031386076, "European": 0.004804125, "Oceanian": 0.021296859, "East Asian": 0.0072455397, "Near Eastern": 0.029094387, "Central/South Asian": 0.005050826, "Sub-Saharan African": 0.0048336256, "African American/Afro-Caribbean": 0.004428509}
7862861	CYP2D6	Normal Metabolizer	2.0	Normal/Routine/ Low Risk	This result signifies that this patient has [X copies of a normal function allele (*_xN)] [X copies of a decreased function allele (*_)] [X copies of a no function allele (*_)]. Based on the genotype result this patient is predicted to be a normal metabolizer of CYP2D6 substrates. There is no reason to selectively adjust the dose of most medications that are metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.42007107, "American": 0.57988566, "European": 0.32166475, "Oceanian": 0.48931405, "East Asian": 0.1527359, "Near Eastern": 0.2670007, "Central/South Asian": 0.34187043, "Sub-Saharan African": 0.15406683, "African American/Afro-Caribbean": 0.22171879}
7863154	CYP2D6	Normal Metabolizer	1.75	Normal/Routine/ Low Risk	This result signifies that this patient has three copies of *41 (*41x3) and one copy of a normal function allele (*_) or [2 copies of a decreased function allele with an activity value of 0.5 (*_x2)]. Based on the genotype result this patient is predicted to be a normal metabolizer of CYP2D6 substrates. There is no reason to selectively adjust the dose of most medications that are metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.0, "American": 0.0, "European": 0.0, "Oceanian": 0.0, "East Asian": 0.0, "Near Eastern": 0.0, "Central/South Asian": 0.0, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": 0.0}
7863172	CYP2D6	Normal Metabolizer	1.25	Normal/Routine/ Low Risk	This result signifies that this patient has [1 copy of a normal function allele (*_)] or [2 copies of a decreased function allele with an activity value of 0.5 (*_x2)] and [1 copy of a decreased function allele with an activity value of 0.25 (*_)] OR *41x3 and [1 copy of a decreased function allele with an activity value of 0.5 (*_)] or [2 copies of a decreased function allele with an activity value of 0.25 (*_x2)]. Based on the genotype result this patient is predicted to be a normal metabolizer of CYP2D6 substrates. There is no reason to selectively adjust the dose of most medications that are metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.11888533, "American": 0.07351474, "European": 0.15507403, "Oceanian": 0.12359433, "East Asian": 0.3547828, "Near Eastern": 0.22410923, "Central/South Asian": 0.23109229, "Sub-Saharan African": 0.073030114, "African American/Afro-Caribbean": 0.07348749}
7863200	CYP2D6	Intermediate Metabolizer	0.75	Abnormal/Priority/High Risk	This result signifies that this patient has has three copies of *41 (*41x3) and one copy of a no function allele (*_) OR [1 copy of a decreased function allele with an activity value of 0.25 (*_)] and [1 copy of a decreased function allele with an activity value of 0.5 (*_)] or [2 copies of a decreased function allele with an activity value of 0.25 (*_x2)] . Based on the genotype result this patient is predicted to be an intermediate metabolizer of CYP2D6 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2D6. To avoid an untoward drug response, dose adjustments may be necessary for medications metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.0074723335, "American": 0.00080644403, "European": 0.0025628314, "Oceanian": 0.00018655165, "East Asian": 0.020004882, "Near Eastern": 0.02042247, "Central/South Asian": 0.0010252715, "Sub-Saharan African": 0.05760366, "African American/Afro-Caribbean": 0.041067164}
7864778	CYP2D6	Intermediate Metabolizer	0.5	Abnormal/Priority/High Risk	This result signifies that this patient has [1 copy of a decreased function allele with an activity value of 0.5 (*_)] or [2 copies of a decreased function allele with an activity value of 0.25 (*_x2)] and one copy of a no function allele (*_) OR two copies for a decreased function allele with an activity value of 0.25 (*_/*_). Based on the genotype result this patient is predicted to be an intermediate metabolizer of CYP2D6 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2D6. To avoid an untoward drug response, dose adjustments may be necessary for medications metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.022830304, "American": 0.0047207433, "European": 0.023932345, "Oceanian": 0.008138877, "East Asian": 0.21193053, "Near Eastern": 0.06410619, "Central/South Asian": 0.040293686, "Sub-Saharan African": 0.0954133, "African American/Afro-Caribbean": 0.08539959}
7866001	CYP2D6	Poor Metabolizer	0.0	Abnormal/Priority/High Risk	This result signifies that the patient has two copies of a no function allele (*_/*_). Based on the genotype result this patient is predicted to be a poor metabolizer of CYP2D6 substrates. This patient may be at a high risk for an adverse or poor response to medications that are metabolized by CYP2D6. To avoid an untoward drug response, dose adjustments or alternative therapeutic agents may be necessary for medications metabolized by the CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.0311798, "American": 0.020160662, "European": 0.065024786, "Oceanian": 0.0031239481, "East Asian": 0.008123729, "Near Eastern": 0.021957064, "Central/South Asian": 0.023507897, "Sub-Saharan African": 0.020398295, "African American/Afro-Caribbean": 0.023474354}
7962766	HLA-A	*31:01 negative	n/a	Routine/Low-Risk	The HLA-A*31:01 allele, which is associated with severe cutaneous adverse reactions among patients taking certain aromatic anticonvulsants, was not detected in this patient. No change in therapy is warranted based on these results. It should be noted that a negative HLA-A*31:01 result does not absolutely rule out the possibility of an adverse drug reaction. Please consult a clinical pharmacist for more information.	1	\N
7962769	HLA-A	*31:01 positive	n/a	Priority/High-Risk	This result signifies that the patient has one or two copies of HLA-A*31:01. Patients with this genotype are at increased risk of severe cutaneous adverse reactions, including Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN), drug reaction with eosinophilia and systemic symptoms (DRESS), and maculopapular exanthema (MPE), with certain aromatic anticonvulsants (e.g., carbamazepine). Alternative therapy may be warranted. Please consult a clinical pharmacist for more information.	1	\N
7960700	SLCO1B1	Increased Function	n/a	Normal/Routine/Low Risk	This result signifies that the patient has two copies of an increased function allele. Based on the genotype result, this patient is predicted to have increased SLCO1B1 function. This means that there is no reason to adjust the dose of most medications that are affected by SLCO1B1 on the basis of SLCO1B1 genetic status at this time. Please consult a clinical pharmacist for more specific information about how SLCO1B1 function influences drug dosing.	3	{"American": 0.0, "European": 0.029916462, "Oceanian": 0.0, "East Asian": 0.0, "Near Eastern": 0.0, "Central/South Asian": 0.0, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": 0.0}
7960729	SLCO1B1	Normal Function	n/a	Normal/Routine/Low Risk	This result signifies that the patient has two copies of a normal function allele. Based on the genotype result, this patient is predicted to have normal SLCO1B1 function. This means that there is no reason to adjust the dose of most medications that are affected by SLCO1B1 on the basis of SLCO1B1 genetic status. Please consult a clinical pharmacist for more specific information about how SLCO1B1 function influences drug dosing.	3	{"American": 0.5776, "European": 0.6564144, "Oceanian": 1.0, "East Asian": 0.75683165, "Near Eastern": 0.64000005, "Central/South Asian": 0.8648222, "Sub-Saharan African": 0.94491136, "African American/Afro-Caribbean": 0.98010004}
7960879	SLCO1B1	Possible Decreased Function	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a uncertain or unknown function allele (*_) and one copy of a no function allele (*_). Based on the genotype result, this patient is predicted to have possible decreased SLCO1B1 function. This patient may be at risk for an adverse response to medications that are affected by SLCO1B1. To avoid an untoward drug response, dose adjustments may be necessary for medications affected by SLCO1B1 (i.e. statins). Please consult a clinical pharmacist for more specific information about how SLCO1B1 function influences drug dosing.	3	{"American": 0.0, "European": 0.00026362084, "Oceanian": 0.0, "East Asian": 0.0011306308, "Near Eastern": 0.0, "Central/South Asian": 0.0000418451, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": 0.0}
7962772	HLA-B	*15:02 negative	n/a	Routine/Low-Risk	The HLA-B*15:02 allele, which is associated with severe cutaneous adverse reactions among patients taking certain aromatic anticonvulsants, was not detected in this patient. No change in therapy is warranted based on these results. It should be noted that a negative HLA-B*15:02 result does not absolutely rule out the possibility of an adverse drug reaction. Please consult a clinical pharmacist for more information.	1	\N
7962775	HLA-B	*15:02 positive	n/a	Priority/High-Risk	This result signifies that the patient has one or two copies of HLA-B*15:02. Patients with this genotype are at increased risk of severe cutaneous adverse reactions, including Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN), with certain aromatic anticonvulsants (e.g., carbamazepine, oxcarbazepine, phenytoin/fosphenytoin). Alternative therapy may be warranted. Please consult a clinical pharmacist for more information.	1	\N
7962778	HLA-B	*57:01 negative	n/a	Normal/Routine/Low Risk	The HLA-B*57:01 allele, associated with abacavir hypersensitivity, was not detected in this patient. The patient may be prescribed abacavir. Please refer to the hospital formulary guidelines for specific dosing information. It should be noted that a negative HLA-B*57:01 result does not absolutely rule out the possibility of some form of abacavir hypersensitivity. Administration of abacavir therapy requires close observation including immediate discontinuation of therapy should any signs or symptoms of hypersensitivity develop.	1	\N
7962781	HLA-B	*57:01 positive	n/a	Abnormal/Priority/High Risk	The HLA-B*57:01 allele, associated with abacavir hypersensitivity, was detected in this patient. HLA-B*5701 positive patients should NOT be prescribed abacavir.	1	\N
7962784	HLA-B	*58:01 negative	n/a	Normal/Routine/Low Risk	The HLA-B*58:01 allele, associated with allopurinol hypersensitivity, was not detected in this patient. Allopurinol can be used per standard dosing guidelines. Patients should be monitored closely for any signs of sensitivity reactions, especially those patients receiving allopurinol (of >300 mg/day), concomitant medications (i.e. thiazide diuretics or penicillin/cephalosporin) or with medical conditions (i.e. chronic kidney disease) that increase the non-genetic risk for allopurinol-related hypersensitivity reactions.	1	\N
7962787	HLA-B	*58:01 positive	n/a	Abnormal/Priority/High Risk	The HLA-B*58:01 allele, associated with allopurinol hypersensitivity, was detected in this patient. Allopurinol is contraindicated.	1	\N
7961462	TPMT	Normal Metabolizer	n/a	Normal/Routine/Low Risk	This result signifies that the patient has two copies of a normal function allele OR one copy of a normal function allele and one copy of a decreased function allele. Based on the genotype result this patient is predicted to be a TPMT normal metabolizer. There is no reason to selectively adjust the dose of most medications that are metabolized by TPMT. However, thiopurines can be affected by a patient's TPMT and NUDT15 phenotype. Please consult a clinical pharmacist for more information about how TPMT and NUDT15 metabolic status influences drug selection and dosing.	3	{"Latino": 0.8923553, "European": 0.90923065, "East Asian": 0.9596651, "Near Eastern": 0.93240434, "Central/South Asian": 0.96327126, "Sub-Saharan African": 0.8933782, "African American/Afro-Caribbean": 0.8646596}
7961509	TPMT	Possible Intermediate Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of an uncertain or unknown function allele and one copy of a no function allele OR one copy of a no function allele and one copy of a decreased function allele. Based on the genotype result this patient has a priority result (TPMT possible intermediate metabolizer) because their activity is not likely to be any higher than that of an intermediate metabolizer; if the uncertain/unknown function allele is also low, activity may be even lower than that of an intermediate metabolizer. This patient may be at risk for an adverse reactions to medications that are metabolized by TPMT (eg. thiopurines). To avoid an untoward drug response, dose adjustments or alternative therapeutic agents may be necessary for medications metabolized by TPMT. However, thiopurines can be affected by a patient's TPMT and NUDT15 phenotype. Please consult a clinical pharmacist for more information about how TPMT and NUDT15metabolic status influences drug selection and dosing.	3	{"Latino": 0.0003095076, "European": 0.00007234227, "East Asian": 0.0000021581852, "Near Eastern": 0.0, "Central/South Asian": 0.0000034757581, "Sub-Saharan African": 0.0026164071, "African American/Afro-Caribbean": 0.0029308118}
7859105	CYP2C19	Poor Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has two copies of a no function allele. Based on the genotype result this patient is predicted to be a poor metabolizer of CYP2C19 substrates. This patient may be at a high risk for an adverse or poor response to medications that are metabolized by CYP2C19. To avoid an untoward drug response, dose adjustments or or alternative therapy may be necessary for medications metabolized by the CYP2C19. Please consult a clinical pharmacist for more information about how CYP2C19 metabolic status influences drug selection and dosing.	3	{"Latino": 0.011408395, "American": 0.014819587, "European": 0.02387743, "Oceanian": 0.5713864, "East Asian": 0.12978691, "Near Eastern": 0.018584846, "Central/South Asian": 0.08156806, "Sub-Saharan African": 0.036714304, "African American/Afro-Caribbean": 0.040512204}
7852135	ABCG2	Poor Function	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has two copies of a decreased function allele. Based on the genotype result, this patient is predicted to have poor ABCG2 function. This patient may be at a high risk for an adverse response to medications that are affected by ABCG2 (i.e. statins). To avoid an untoward drug response, dose adjustments or alternative therapeutic agents may be necessary for medications affected by ABCG2. Please consult a clinical pharmacist for more specific information about how ABCG2 function influences drug dosing.	3	{"Latino": 0.05035536, "American": 0.040000003, "European": 0.010732961, "Oceanian": 0.0419122, "East Asian": 0.09431041, "Near Eastern": 0.00426409, "Central/South Asian": 0.00868624, "Sub-Saharan African": 0.000034175762, "African American/Afro-Caribbean": 0.0012156549}
7852138	ABCG2	Decreased Function	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a normal function allele and one copy of a no decreased allele . Based on the genotype result, this patient is predicted to have decreased ABCG2 function. This patient may be at risk for an adverse response to medications that are affected by ABCG2. To avoid an untoward drug response, dose adjustments may be necessary for medications affected by ABCG2 (i.e. statins). Please consult a clinical pharmacist for more specific information about how ABCG2 function influences drug dosing.	3	{"Latino": 0.34808928, "American": 0.32000002, "European": 0.18573408, "Oceanian": 0.32562497, "East Asian": 0.4255792, "Near Eastern": 0.122071825, "Central/South Asian": 0.1690275, "Sub-Saharan African": 0.011623656, "African American/Afro-Caribbean": 0.06730118}
7852141	ABCG2	Normal Function	n/a	Normal/Routine/Low Risk	This result signifies that the patient has two copies of a normal function allele. Based on the genotype result, this patient is predicted to have normal ABCG2 function. This means that there is no reason to adjust the dose of most medications that are affected by ABCG2 on the basis of ABCG2 genetic status. Please consult a clinical pharmacist for more specific information about how ABCG2 function influences drug dosing.	3	{"Latino": 0.6015554, "American": 0.64000005, "European": 0.8035329, "Oceanian": 0.63246274, "East Asian": 0.4801104, "Near Eastern": 0.87366414, "Central/South Asian": 0.8222862, "Sub-Saharan African": 0.9883421, "African American/Afro-Caribbean": 0.9314832}
7852144	CACNA1S	Malignant Hyperthermia Susceptibility	n/a	Abnormal/Priority/High Risk	This result signifies that this patient has one copy of a variant [variant] associated with malignant hyperthermia susceptibility. Halogenated volatile anesthetics or depolarizing muscle relaxants are relatively contraindicated in persons with MHS. They should not be used, except in extraordinary circumstances where the benefits outweigh the risks. Please consult a MHS specialist or contact MHAUS (https://www.mhaus.org/healthcare-professionals/) for further information.	2	\N
7852152	CACNA1S	Uncertain Susceptibility	n/a	Normal Risk	Variation in RYR1 and/or CACNA1S genes is associated with increased risk of Malignant hyperthermia after administration of depolarizing muscle relaxants and potent volatile anesthetics. Although listed causative CACNA1S variants were NOT detected in this patient, it should be noted that this finding does not absolutely rule out the possibility of malignant hyperthermia. These results should be interpreted in the context of other genetic and clinical findings, family history and other laboratory data.	2	\N
7852155	CFTR	ivacaftor responsive in CF patients	n/a	\N	\N	1	\N
7857617	CFTR	ivacaftor non-responsive in CF patients	n/a	\N	\N	1	\N
7857813	CYP2B6	Poor Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has two copies of a no function allele OR two copies of a decreased function allele OR one copy of a no function allele and one copy of a decreased function allele. Based on the genotype result this patient is predicted to be a poor metabolizer of CYP2B6 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2B6. To avoid an untoward drug response, dose adjustments or or alternative therapy may be necessary for medications metabolized by CYP2B6. Please consult a clinical pharmacist for more information about how CYP2B6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.09452413, "European": 0.07428478, "Oceanian": 0.4096, "East Asian": 0.0436291, "Near Eastern": 0.127449, "Central/South Asian": 0.059536003, "Sub-Saharan African": 0.23673655, "African American/Afro-Caribbean": 0.15714757}
7858070	CYP2B6	Indeterminate	n/a	none	This result signifies that the patient has an allele combination with uncertain and/or unknown function alleles. The expected phenotype for this patient cannot be determined currently based on the CYP2B6 diplotype result. Please consult a clinical pharmacist for more specific information about how CYP2B6 function influences drug dosing.	3	{"Latino": 0.013596146, "European": 0.06145065, "Oceanian": 0.0, "East Asian": 0.020025712, "Near Eastern": 0.0, "Central/South Asian": 0.014973663, "Sub-Saharan African": 0.25210795, "African American/Afro-Caribbean": 0.031204166}
7857620	CYP2B6	Ultrarapid Metabolizer	n/a	Normal/Routine/Low Risk	This result signifies that the patient has two copies of increased function alleles. Based on the genotype result this patient is predicted to be an ultrarapid metabolizer of CYP2B6 substrates. There is no reason to selectively adjust the dose of most medications that are metabolized by CYP2B6. Please consult a clinical pharmacist for more information about how CYP2B6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.011284955, "European": 0.0016704409, "Oceanian": 0.0, "East Asian": 0.007088209, "Near Eastern": 0.010816, "Central/South Asian": 0.009801, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": 0.000106068765}
7857623	CYP2B6	Rapid Metabolizer	n/a	Normal/Routine/Low Risk	This result signifies that the patient has one copy of a normal function allele and one copy of an increased function allele. Based on the genotype result this patient is predicted to be a rapid metabolizer of CYP2B6 substrates. There is no reason to selectively adjust the dose of most medications that are metabolized by CYP2B6. Please consult a clinical pharmacist for more information about how CYP2B6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.1231214, "European": 0.05357082, "Oceanian": 0.0, "East Asian": 0.11734093, "Near Eastern": 0.112112, "Central/South Asian": 0.12859802, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": 0.011896482}
7857631	CYP2B6	Normal Metabolizer	n/a	Normal/Routine/Low Risk	This result signifies that the patient has two copies of normal function alleles. Based on the genotype result this patient is predicted to be an normal metabolizer of CYP2B6 substrates. There is no reason to selectively adjust the dose of most medications that are metabolized by CYP2B6. Please consult a clinical pharmacist for more information about how CYP2B6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.33582056, "European": 0.42950228, "Oceanian": 0.12960002, "East Asian": 0.48562673, "Near Eastern": 0.29052103, "Central/South Asian": 0.42183065, "Sub-Saharan African": 0.14307445, "African American/Afro-Caribbean": 0.333572}
7857654	CYP2B6	Intermediate Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a normal function allele and one copy of a no function allele OR one copy of a normal function allele and one copy of a decreased function allele OR one copy of an increased function allele and one copy of a no function allele OR one copy of an increased function allele and one copy of a decreased function allele. Based on the genotype result this patient is predicted to be an intermediate metabolizer of CYP2B6 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2B6. To avoid an untoward drug response, dose adjustments or alternative therapeutic agents may be necessary for medications metabolized by CYP2B6. Please consult a clinical pharmacist for more information about how CYP2B6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.42165288, "European": 0.37952113, "Oceanian": 0.46080005, "East Asian": 0.32628936, "Near Eastern": 0.459102, "Central/South Asian": 0.36526063, "Sub-Saharan African": 0.36808127, "African American/Afro-Caribbean": 0.4660738}
7859031	CYP2C19	Likely Poor Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a decreased function allele and one copy of a no function allele. Based on the genotype result this patient MAY be a poor metabolizer of CYP2C19 substrates. This patient may be at a high risk for an adverse or poor response to medications that are metabolized by CYP2C19. To avoid an untoward drug response, dose adjustments or or alternative therapy may be necessary for medications metabolized by the CYP2C19. Please consult a clinical pharmacist for more information about how CYP2C19 metabolic status influences drug selection and dosing.	3	{"Latino": 0.0004440685, "American": 0.0, "European": 0.00020405183, "Oceanian": 0.0, "East Asian": 0.0004349198, "Near Eastern": 0.0, "Central/South Asian": 0.0, "Sub-Saharan African": 0.010332189, "African American/Afro-Caribbean": 0.007090685}
7858932	CYP2C19	Intermediate Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a normal function allele and one copy of a no function allele OR one copy of an increased function and one copy of a no function allele. Based on the genotype result this patient is predicted to be an intermediate metabolizer of CYP2C19 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2C19. To avoid an untoward drug response, dose adjustments or alternative therapeutic agents may be necessary for medications metabolized by CYP2C19. Please consult a clinical pharmacist for more information about how CYP2C19 metabolic status influences drug selection and dosing.	3	{"Latino": 0.19035932, "American": 0.21383229, "European": 0.26108757, "Oceanian": 0.36902928, "East Asian": 0.45928204, "Near Eastern": 0.2354828, "Central/South Asian": 0.40806636, "Sub-Saharan African": 0.29945874, "African American/Afro-Caribbean": 0.31398684}
7859185	CYP2C19	Indeterminate	n/a	none	This result signifies that the patient has an allele combination with uncertain and/or unknown function alleles. The expected phenotype for this patient cannot be determined currently based on the CYP2C19 diplotype result. Please consult a clinical pharmacist for more specific information about how CYP2C19 function influences drug dosing.	3	{"Latino": 0.0, "American": 0.0, "European": 0.0, "Oceanian": 0.0, "East Asian": 0.0034064606, "Near Eastern": 0.0, "Central/South Asian": 0.0, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": 0.0022393465}
7858829	CYP2C19	Normal Metabolizer	n/a	Normal/Routine/Low Risk	This result signifies that the patient has two copies of a normal function allele. Based on the genotype result this patient is predicted to be an normal metabolizer of CYP2C19 substrates. There is no reason to selectively adjust the dose of most medications that are metabolized by CYP2C19. Please consult a clinical pharmacist for more information about how CYP2C19 metabolic status influences drug selection and dosing.	3	{"Latino": 0.5249766, "American": 0.62755567, "European": 0.39611652, "Oceanian": 0.035006005, "East Asian": 0.38055435, "Near Eastern": 0.45192146, "Central/South Asian": 0.29552925, "Sub-Saharan African": 0.36977687, "African American/Afro-Caribbean": 0.32805592}
7858859	CYP2C19	Likely Intermediate Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a normal function allele and one copy of a decreased function allele OR one copy of an increased function allele and one copy of a decreased function allele OR two copies of a decreased function allele. Based on the genotype result this patient MAY be an intermediate metabolizer of CYP2C19 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2C19. To avoid an untoward drug response, dose adjustments or alternative therapeutic agents may be necessary for medications metabolized by CYP2C19. Please consult a clinical pharmacist for more information about how CYP2C19 metabolic status influences drug selection and dosing.	3	{"Latino": 0.003709162, "American": 0.0, "European": 0.0011160374, "Oceanian": 0.0, "East Asian": 0.00076989824, "Near Eastern": 0.0, "Central/South Asian": 0.0, "Sub-Saharan African": 0.042863965, "African American/Afro-Caribbean": 0.027788177}
7858817	CYP2C19	Ultrarapid Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has two copies of an increased function allele. Based on the genotype result this patient is predicted to be an ultrarapid metabolizer of CYP2C19 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2C19. To avoid an untoward drug response, dose adjustments or alternative therapeutic agents may be necessary for medications metabolized by CYP2C19. Please consult a clinical pharmacist for more information about how CYP2C19 metabolic status influences drug selection and dosing.	3	{"Latino": 0.02774172, "American": 0.0074097984, "European": 0.04641379, "Oceanian": 0.003249, "East Asian": 0.00042194634, "Near Eastern": 0.036642652, "Central/South Asian": 0.029163336, "Sub-Saharan African": 0.030045323, "African American/Afro-Caribbean": 0.042943195}
7858820	CYP2C19	Rapid Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a normal function allele and one copy of an increased function allele. Based on the genotype result this patient is predicted to be a rapid metabolizer of CYP2C19 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2C19. To avoid an untoward drug response, dose adjustments or alternative therapeutic agents may be necessary for medications metabolized by CYP2C19. Please consult a clinical pharmacist for more information about how CYP2C19 metabolic status influences drug selection and dosing.	3	{"Latino": 0.24136075, "American": 0.13638271, "European": 0.2711846, "Oceanian": 0.021329276, "East Asian": 0.025343522, "Near Eastern": 0.2573682, "Central/South Asian": 0.18567303, "Sub-Saharan African": 0.21080859, "African American/Afro-Caribbean": 0.2373838}
7860183	CYP2C9	Indeterminate	n/a	none	This result signifies that the patient has an allele combination with uncertain and/or unknown function alleles. The expected phenotype for this patient cannot be determined currently based on the CYP2C9 diplotype result. Please consult a clinical pharmacist for more specific information about how CYP2C9 function influences drug dosing.	3	{"Latino": 0.0009997501, "American": 0.0, "European": 0.00059991, "Oceanian": 0.0, "East Asian": 0.0046076896, "Near Eastern": 0.0, "Central/South Asian": 0.0037963898, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": 0.0}
7859506	CYP2C9	Normal Metabolizer	2.0	Normal/Routine/Low Risk	This result signifies that the patient has two copies of a normal function allele. Based on the genotype result, this patient is predicted to be a CYP2C9 Normal metabolizer. Based only on the CYP2C9 genotype, there is no reason to adjust the dose of most medications that are affected by CYP2C9. Please consult a clinical pharmacist for more specific information about how CYP2C9 function influences drug dosing.	3	{"Latino": 0.74342215, "American": 0.83149743, "European": 0.62845254, "Oceanian": 0.9122409, "East Asian": 0.8378542, "Near Eastern": 0.61125296, "Central/South Asian": 0.5961676, "Sub-Saharan African": 0.73114437, "African American/Afro-Caribbean": 0.75866354}
7859511	CYP2C9	Intermediate Metabolizer	1.5	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a normal function allele and one copy of a decreased function allele. Based on the genotype result, this patient is predicted to be a CYP2C9 intermediate metabolizer (activity score of 1.5). This patient may be at risk for an adverse response to medications that are affected by CYP2C9. Please consult a clinical pharmacist for more specific information about how CYP2C9 intermediate metabolizer status influences drug dosing.	3	{"Latino": 0.1647683, "American": 0.10592343, "European": 0.20758142, "Oceanian": 0.05599055, "East Asian": 0.052658077, "Near Eastern": 0.2097067, "Central/South Asian": 0.17885593, "Sub-Saharan African": 0.21372117, "African American/Afro-Caribbean": 0.1863267}
7859555	CYP2C9	Intermediate Metabolizer	1.0	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a normal function allele and one copy of a no function allele OR two copies of decreased function alleles. Based on the genotype result, this patient is predicted to be a CYP2C9 intermediate metabolizer (activity score of 1). This patient may be at risk for an adverse response to medications that are affected by CYP2C9. Please consult a clinical pharmacist for more specific information about how CYP2C9 intermediate metabolizer status influences drug dosing.	3	{"Latino": 0.08109343, "American": 0.05818467, "European": 0.13767911, "Oceanian": 0.03061276, "East Asian": 0.098925985, "Near Eastern": 0.1494271, "Central/South Asian": 0.18352722, "Sub-Saharan African": 0.049747862, "African American/Afro-Caribbean": 0.049812526}
7859815	CYP2C9	Poor Metabolizer	0.5	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a decreased function allele and one copy of a no function allele. Based on the genotype result, this patient is predicted to be a CYP2C9 poor metabolizer. This patient may be at high risk for an adverse response to medications that are affected by CYP2C9. Please consult a clinical pharmacist for more specific information about how CYP2C9 intermediate metabolizer status influences drug dosing.	3	{"Latino": 0.007974847, "American": 0.0034911723, "European": 0.019907156, "Oceanian": 0.0009130932, "East Asian": 0.0030826868, "Near Eastern": 0.022547128, "Central/South Asian": 0.025517693, "Sub-Saharan African": 0.0049882242, "African American/Afro-Caribbean": 0.004712071}
7860090	CYP2C9	Poor Metabolizer	0.0	Abnormal/Priority/High Risk	This result signifies that the patient has two copies of no function alleles. Based on the genotype result, this patient is predicted to be a CYP2C9 poor metabolizer. This patient may be at high risk for an adverse response to medications that are affected by CYP2C9. Please consult a clinical pharmacist for more specific information about how CYP2C9 intermediate metabolizer status influences drug dosing.	3	{"Latino": 0.0017415384, "American": 0.00090327376, "European": 0.0057798154, "Oceanian": 0.00024261088, "East Asian": 0.0028714235, "Near Eastern": 0.007066085, "Central/South Asian": 0.012135133, "Sub-Saharan African": 0.0003982905, "African American/Afro-Caribbean": 0.00048520204}
7862400	CYP2D6	Ultrarapid Metabolizer	≥4.0	Abnormal/Priority/High Risk	This result signifies that this patient has [X copies of a normal function allele (*_xN)] [X copies of a decreased function allele (*_)] [X copies of a no function allele (*_)]. Based on the genotype result this patient is predicted to be an ultrarapid metabolizer of CYP2D6 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2D6. To avoid an untoward drug response, dose adjustments may be necessary for medications metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.0012809848, "American": 0.0015109289, "European": 0.0018874556, "Oceanian": 0.0, "East Asian": 0.0007779561, "Near Eastern": 0.0, "Central/South Asian": 0.0, "Sub-Saharan African": 0.0038317435, "African American/Afro-Caribbean": 0.0}
7862396	CYP2D6	Ultrarapid Metabolizer	≥3.75	Abnormal/Priority/High Risk	This result signifies that this patient has [X copies of a normal function allele (*_xN)] [X copies of a decreased function allele (*_)] [X copies of a no function allele (*_)]. Based on the genotype result this patient is predicted to be an ultrarapid metabolizer of CYP2D6 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2D6. To avoid an untoward drug response, dose adjustments may be necessary for medications metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.0, "American": 0.0, "European": 0.0, "Oceanian": 0.0, "East Asian": 0.0, "Near Eastern": 0.0, "Central/South Asian": 0.0, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": 0.0}
7862434	CYP2D6	Ultrarapid Metabolizer	≥3.5	Abnormal/Priority/High Risk	This result signifies that this patient has [X copies of a normal function allele (*_xN)] [X copies of a decreased function allele (*_)] [X copies of a no function allele (*_)]. Based on the genotype result this patient is predicted to be an ultrarapid metabolizer of CYP2D6 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2D6. To avoid an untoward drug response, dose adjustments may be necessary for medications metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.00008051411, "American": 0.00001657463, "European": 0.000031193038, "Oceanian": 0.0, "East Asian": 0.00004386605, "Near Eastern": 0.0, "Central/South Asian": 0.0, "Sub-Saharan African": 0.0030223487, "African American/Afro-Caribbean": 0.0}
7862486	CYP2D6	Ultrarapid Metabolizer	≥3.0	Abnormal/Priority/High Risk	This result signifies that this patient has [X copies of a normal function allele (*_xN)] [X copies of a decreased function allele (*_)] [X copies of a no function allele (*_)]. Based on the genotype result this patient is predicted to be an ultrarapid metabolizer of CYP2D6 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2D6. To avoid an untoward drug response, dose adjustments may be necessary for medications metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.00035315607, "American": 0.0002839765, "European": 0.0008605249, "Oceanian": 0.0, "East Asian": 0.00018026348, "Near Eastern": 0.0, "Central/South Asian": 0.0, "Sub-Saharan African": 0.001428226, "African American/Afro-Caribbean": 0.0}
7867179	CYP2D6	Indeterminate	n/a	none	This result signifies that the patient has an allele combination with uncertain and/or unknown function alleles. The expected phenotype for this patient cannot be determined currently based on the CYP2D6 diplotype result. Please consult a clinical pharmacist for more specific information about how CYP2D6 function influences drug dosing.	3	{"Latino": 0.041558996, "American": 0.02454997, "European": 0.03725156, "Oceanian": 0.087338224, "East Asian": 0.066782884, "Near Eastern": 0.03744279, "Central/South Asian": 0.09993659, "Sub-Saharan African": 0.09009597, "African American/Afro-Caribbean": 0.038868744}
7862615	CYP2D6	Ultrarapid Metabolizer	3.0	Abnormal/Priority/High Risk	This result signifies that this patient has [X copies of a normal function allele (*_xN)] [X copies of a decreased function allele (*_)] [X copies of a no function allele (*_)]. Based on the genotype result this patient is predicted to be an ultrarapid metabolizer of CYP2D6 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2D6. To avoid an untoward drug response, dose adjustments may be necessary for medications metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.035694193, "American": 0.048732717, "European": 0.019382542, "Oceanian": 0.16405001, "East Asian": 0.006179998, "Near Eastern": 0.06435209, "Central/South Asian": 0.014773737, "Sub-Saharan African": 0.019435417, "African American/Afro-Caribbean": 0.025694855}
7865471	CYP2D6	Intermediate Metabolizer	0.25	Abnormal/Priority/High Risk	This result signifies that this patient has one copy of a decreased function allele with an activity value of 0.25 (*_) and one copy of a no function allele (*_). Based on the genotype result this patient is predicted to be an intermediate metabolizer of CYP2D6 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2D6. To avoid an untoward drug response, dose adjustments may be necessary for medications metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.03277562, "American": 0.0138169695, "European": 0.07070104, "Oceanian": 0.010012345, "East Asian": 0.08220821, "Near Eastern": 0.06670452, "Central/South Asian": 0.060946763, "Sub-Saharan African": 0.027220901, "African American/Afro-Caribbean": 0.024385082}
7879280	CYP3A5	Normal Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has two copies of a normal function allele. Patients with this genotype are expected to require higher starting tacrolimus dosing (1.5 times to 2 times the standard dose-maximum starting dose not to exceed 0.3mg/kg/day). Further dose adjustments or selection of alternative therapy may be necessary due to other clinical factors (e.g., medication interactions, or hepatic function). Please consult a clinical pharmacist for more specific dosing information.	3	{"Latino": 0.029857205, "European": 0.005491413, "East Asian": 0.064288594, "Near Eastern": 0.014869832, "Central/South Asian": 0.106746115, "Sub-Saharan African": 0.22983262, "African American/Afro-Caribbean": 0.20507748}
7879283	CYP3A5	Intermediate Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a normal function allele and one copy of a no function allele. Patients with this genotype are expected to require higher starting tacrolimus dosing (1.5 times to 2 times the standard dose-maximum starting dose not to exceed 0.3mg/kg/day). Further dose adjustments or selection of alternative therapy may be necessary due to other clinical factors (e.g., medication interactions, or hepatic function). Please consult a clinical pharmacist for more specific dosing information.	3	{"Latino": 0.28587034, "European": 0.13722531, "East Asian": 0.37852672, "Near Eastern": 0.21414419, "Central/South Asian": 0.43994826, "Sub-Saharan African": 0.499152, "African American/Afro-Caribbean": 0.4955547}
7879288	CYP3A5	Poor Metabolizer	n/a	Normal/Routine/Low Risk	This result signifies that the patient has two copies of a no function allele. Patients with this genotype are expected to require standard tacrolimus dosing. Please consult a clinical pharmacist for more specific dosing information.	3	{"Latino": 0.68427247, "European": 0.85728335, "East Asian": 0.5571847, "Near Eastern": 0.770986, "Central/South Asian": 0.45330563, "Sub-Saharan African": 0.2710154, "African American/Afro-Caribbean": 0.2993679}
7879296	CYP3A5	Possible Intermediate Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a normal function allele and one copy of an uncertain or unknown function allele. Patients with this genotype are expected to require higher starting tacrolimus dosing (1.5 times to 2 times the standard dose-maximum starting dose not to exceed 0.3mg/kg/day). Further dose adjustments or selection of alternative therapy may be necessary due to other clinical factors (e.g., medication interactions, or hepatic function). Please consult a clinical pharmacist for more specific dosing information.	3	{"Latino": 0.0, "European": 0.0, "East Asian": 0.0, "Near Eastern": 0.0, "Central/South Asian": 0.0, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": 0.0}
7879300	CYP3A5	Indeterminate	n/a	none	This result signifies that the patient has an allele combination with uncertain and/or unknown function alleles. The expected phenotype for this patient cannot be determined currently based on the CYP3A5 diplotype result. Please consult a clinical pharmacist for more specific information about how CYP3A5 function influences drug dosing.	3	{"Latino": 0.0, "European": 0.0, "East Asian": 0.0, "Near Eastern": 0.0, "Central/South Asian": 0.0, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": 0.0}
7879312	DPYD	Normal Metabolizer	2.0	Normal/Routine/Low Risk	This result signifies that the patient has two copies of normal function DPYD alleles. Based on the genotype result this patient is predicted to be DPYD Normal Metabolizer with a DPYD activity score of 2. For this genotype, no selective dose adjustment is indicated for medications that are metabolized by DPD. Please consult a clinical pharmacist for more information about how DPD metabolic status influences drug selection and dosing.	2	\N
7880910	DPYD	Intermediate Metabolizer	1.5	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a normal function allele and one copy of a decreased function allele of the DPYD gene. Based on the genotype result this patient is predicted to be a DPYD Intermediate Metabolizer with a DPYD activity score of 1.5. This patient may be at risk for adverse drug reactions to medications that are metabolized by DPD (i.e. 5-fluorouracil, capecitabine, and tegafur) and a dose adjustment may be indicated. Please consult a clinical pharmacist for more information about how DPD metabolic status influences drug selection and dosing.	2	\N
7881304	DPYD	Intermediate Metabolizer	1.0	Abnormal/Priority/High Risk	This result signifies that the patient has either one copy of a normal function allele and one copy of a no function allele of the DPYD gene OR two copies of decreased function alleles of the DPYD gene. Based on the genotype result this patient is predicted to be a DPYD Intermediate Metabolizer with a DPYD activity score of 1. This patient may be at risk for adverse drug reactions to medications that are metabolized by DPD (i.e. 5-fluorouracil, capecitabine, and tegafur) and a dose adjustment may be indicated. Please consult a clinical pharmacist for more information about how DPD metabolic status influences drug selection and dosing.	2	\N
7882511	DPYD	Poor Metabolizer	0.5	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a decreased function allele and one copy of a no function allele of the DPYD gene. Based on the genotype result this patient is predicted to be a DPYD Poor Metabolizer with a DPYD activity score of 0.5. This patient may be at risk for adverse drug reactions to medications that are metabolized by DPD (i.e. 5-fluorouracil, capecitabine, and tegafur) and a dose adjustment or alternative therapeutic agents may be indicated. Please consult a clinical pharmacist for more information about how DPD metabolic status influences drug selection and dosing.	2	\N
7882660	DPYD	Poor Metabolizer	0.0	Abnormal/Priority/High Risk	This result signifies that the patient has two copies of no function alleles of the DPYD gene. Based on the genotype result this patient is predicted to be a DPYD Poor Metabolizer with a DPYD activity score of 0. This patient may be at risk for adverse drug reactions to medications that are metabolized by DPD (i.e. 5-fluorouracil, capecitabine, and tegafur) and alternative therapeutic agents may be indicated. Please consult a clinical pharmacist for more information about how DPD metabolic status influences drug selection and dosing.	2	\N
7882900	G6PD	Deficient	n/a	Abnormal/Priority/High Risk	Based on the genotype result, this patient is predicted to be G6PD deficient and is at risk for developing hemolytic anemia when exposed to certain medications (such as dapsone, methylene blue, pegloticase, primaquine (at certain doses), rasburicase, tafenoquine, toluidine blue) or foods (such as fava beans). Please consult a clinical pharmacist for more information.	2	\N
7882993	G6PD	Deficient with CNSHA	n/a	Abnormal/Priority/High Risk	Based on the genotype result, this patient is predicted to be G6PD deficient with CNSHA and is at risk for developing or worsening hemolytic anemia when exposed to certain medications (such as dapsone, methylene blue, pegloticase, primaquine (at certain doses), rasburicase, tafenoquine, toluidine blue) or foods (such as fava beans). Please consult a clinical pharmacist for more information.	2	\N
7899563	G6PD	Indeterminate	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has an allele combination with uncertain and/or unknown function alleles. The expected phenotype for this patient cannot be determined currently based on genotype alone. A G6PD enzyme activity test is recommended to assess for G6PD deficiency. Please consult a clinical pharmacist for more specific information about how G6PD function influences drug dosing.	2	\N
7882893	G6PD	Normal	n/a	Normal Risk	Based on the genotype result, this patient is predicted to have normal G6PD enzyme activity. This means there is no reason to selectively avoid G6PD associated medications based on the G6PD status alone. Please consult a clinical pharmacist for more information.	2	\N
7883097	G6PD	Variable	n/a	Abnormal/Priority/High Risk	This patient carries one copy of a deficient G6PD allele and one copy of a normal G6PD allele. Due to X inactivation, patients who are heterozygous with one deficient allele and one normal allele may exhibit G6PD activity ranging from normal to deficient. A G6PD enzyme activity test is recommended to assess for G6PD deficiency. Please consult a clinical pharmacist for more information.	2	\N
7900683	MT-RNR1	increased risk of aminoglycoside-induced hearing loss	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has a copy of the MT-RNR1 [variant]. Based on this genotype result, the patient is predicted to be at increased risk of aminoglycoside-induced hearing loss. This means that the patient is likely to develop irreversible hearing loss if aminoglycosides (e.g. amikacin, gentamicin, tobramycin) are prescribed. Please consult a clinical pharmacist or Infectious Diseases Service for help selecting alternative therapies.	2	\N
7900688	MT-RNR1	normal risk of aminoglycoside-induced hearing loss	n/a	Normal/Routine/Low Risk	This result signifies that MT-RNR1 variants associated with aminoglycoside-induced hearing loss were not detected in this patient. Based on this genotype result, no change in aminoglycoside therapy is warranted. It should be noted that this result does not absolutely rule out the possibility of the patient developing ototoxicity with aminoglycoside use.	2	\N
7900691	MT-RNR1	uncertain risk of aminoglycoside-induced hearing loss	n/a	Normal/Routine/Low Risk	This result signifies that the patient has a copy of MT-RNR1 [variant]. At this time, the association of this allele with aminoglycoside-induced hearing loss is unknown/uncertain. Based on this genotype result, no change in aminoglycoside therapy is warranted. It should be noted that this result does not absolutely rule out the possibility of the patient developing ototoxicity with aminoglycoside use.	2	\N
7900713	NAT2	Rapid Metabolizer	n/a	Priority/High Risk	This result signifies that the patient has inherited two increased function alleles. Based on the genotype result this patient is predicted to be a rapid metabolizer of NAT2 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by NAT2. To avoid an untoward drug response, dose adjustments or alternative therapeutic agents may be necessary for medications metabolized by NAT2. Please consult a clinical pharmacist for more information about how NAT2 metabolic status influences drug selection and dosing.	2	\N
7900718	NAT2	Intermediate Metabolizer	n/a	Priority/High Risk	This result signifies that the patient has inherited one increased function allele and one decreased function allele. Based on the genotype result this patient is predicted to be an intermediate metabolizer of NAT2 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by NAT2. To avoid an untoward drug response, dose adjustments or alternative therapeutic agents may be necessary for medications metabolized by NAT2. Please consult a clinical pharmacist for more information about how NAT2 metabolic status influences drug selection and dosing.	2	\N
7900800	NAT2	Poor Metabolizer	n/a	Priority/High Risk	This result signifies that the patient has inherited two decreased function alleles. Based on the genotype result this patient is predicted to be a poor metabolizer of NAT2 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by NAT2. To avoid an untoward drug response, dose adjustments or alternative therapeutic agents may be necessary for medications metabolized by NAT2. Please consult a clinical pharmacist for more information about how NAT2 metabolic status influences drug selection and dosing.	2	\N
7901622	NAT2	Indeterminate	n/a	none	This result signifies that the patient has inhertied an allele combination with uncertain and/or unknown function alleles. The expected phenotype for this patient cannot be determined currently based on the NAT2 diplotype result. Please consult a clinical pharmacist for more specific information about how NAT2 function influences drug dosing.	2	\N
7902497	NUDT15	Normal Metabolizer	n/a	Normal/Routine/Low Risk	This result signifies that the patient has two copies of a normal function allele OR one copy of a normal function allele and one copy of a decreased function allele. Based on the genotype result this patient is predicted to be a NUDT15 normal metabolizer. There is no reason to selectively adjust the dose of most medications that are metabolized by NUDT15. Please consult a clinical pharmacist for more information about how NUDT15 metabolic status influences drug selection and dosing.	3	{"Latino": 0.94649667, "European": 0.98632336, "East Asian": 0.8551724, "Central/South Asian": 0.8657786}
7902503	NUDT15	Intermediate Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a normal function allele and one copy of a no function allele OR two copies of a decreased function allele. Based on the genotype result this patient is predicted to be a NUDT15 intermediate metabolizer. This patient may be at risk for an adverse reactions to medications that are metabolized by NUDT15 (eg thiopurines). To avoid an untoward drug response, dose adjustments or alternative therapeutic agents may be necessary for medications metabolized by NUDT15. Please consult a clinical pharmacist for more information about how NUDT15 metabolic status influences drug selection and dosing.	3	{"Latino": 0.0527679, "European": 0.013629507, "East Asian": 0.13750981, "Central/South Asian": 0.12932494}
7902520	NUDT15	Possible Intermediate Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of an uncertain function allele and one copy of a no function allele. Based on the genotype result this patient is predicted to be a NUDT15 possible intermediate metabolizer. This patient may be at risk for an adverse reactions to medications that are metabolized by NUDT15 (eg thiopurines). To avoid an untoward drug response, dose adjustments or alternative therapeutic agents may be necessary for medications metabolized by NUDT15. Please consult a clinical pharmacist for more information about how NUDT15 metabolic status influences drug selection and dosing.	3	{"Latino": 0.0, "European": 0.0, "East Asian": 0.0, "Central/South Asian": 0.0}
7902588	NUDT15	Poor Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has two copies of a no function allele OR one copy of a no function allele and one copy of a decreased function allele. Based on the genotype result this patient is predicted to be a NUDT15 poor metabolizer. This patient may be at a high risk for an adverse reactions to medications that are metabolized by NUDT15 (eg. thiopurines). To avoid an untoward drug response, dose adjustments or or alternative therapy may be necessary for medications metabolized by NUDT15. Please consult a clinical pharmacist for more information about how NUDT15 metabolic status influences drug selection and dosing.	3	{"Latino": 0.00073546247, "European": 0.000047192545, "East Asian": 0.0073177223, "Central/South Asian": 0.004896416}
7902679	NUDT15	Indeterminate	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a normal function allele and one copy of an uncertain function allele OR one copy of a decreased function allele and one copy of an uncertain function allele OR two copies of an uncertain function allele. The expected phenotype for this patient cannot be determined currently based on the NUDT15 diplotype result. If thiopurines are required and NUDT15 status is unknown, monitor closely for toxicity. Please consult a clinical pharmacist for more specific information about how NUDT15 function influences drug dosing.	3	{"Latino": 0.0, "European": 0.0, "East Asian": 0.0, "Central/South Asian": 0.0}
\.


--
-- Data for Name: gene_result_diplotype; Type: TABLE DATA; Schema: cpic; Owner: -
--

COPY cpic.gene_result_diplotype (id, functionphenotypeid, diplotype, diplotypekey, frequency) FROM stdin;
7941221	7941119	c.4747C>T/c.14210G>A	{"RYR1": {"c.4747C>T": 1, "c.14210G>A": 1}}	\N
7941222	7941119	c.6743G>A/c.7360C>T	{"RYR1": {"c.6743G>A": 1, "c.7360C>T": 1}}	\N
7941223	7941119	c.6488G>C/c.7210G>A	{"RYR1": {"c.6488G>C": 1, "c.7210G>A": 1}}	\N
7941224	7941119	c.7354C>T/c.11953T>C	{"RYR1": {"c.7354C>T": 1, "c.11953T>C": 1}}	\N
7941225	7941119	c.1840C>T/c.14126C>T	{"RYR1": {"c.1840C>T": 1, "c.14126C>T": 1}}	\N
7941226	7941119	c.152C>A/c.1840C>T	{"RYR1": {"c.152C>A": 1, "c.1840C>T": 1}}	\N
7941227	7941119	c.479A>G/c.7123G>A	{"RYR1": {"c.479A>G": 1, "c.7123G>A": 1}}	\N
7941228	7941119	c.7048G>A/c.9676G>C	{"RYR1": {"c.7048G>A": 1, "c.9676G>C": 1}}	\N
7941229	7941119	c.2122G>A/c.7372C>T	{"RYR1": {"c.2122G>A": 1, "c.7372C>T": 1}}	\N
7941230	7941119	c.947G>T/c.7522C>T	{"RYR1": {"c.947G>T": 1, "c.7522C>T": 1}}	\N
7941231	7941119	c.7523G>A/c.8638G>A	{"RYR1": {"c.7523G>A": 1, "c.8638G>A": 1}}	\N
7941232	7941119	c.7123G>A/c.13760C>T	{"RYR1": {"c.7123G>A": 1, "c.13760C>T": 1}}	\N
7941233	7941119	c.6037A>C/c.7123G>A	{"RYR1": {"c.6037A>C": 1, "c.7123G>A": 1}}	\N
7941234	7941119	c.992_994dup/c.12149C>A	{"RYR1": {"c.12149C>A": 1, "c.992_994dup": 1}}	\N
7941235	7941119	c.1597C>T/c.6847A>C	{"RYR1": {"c.1597C>T": 1, "c.6847A>C": 1}}	\N
7941236	7941119	c.526G>A/c.982C>T	{"RYR1": {"c.526G>A": 1, "c.982C>T": 1}}	\N
7941237	7941119	c.7089C>G/c.7282G>A	{"RYR1": {"c.7089C>G": 1, "c.7282G>A": 1}}	\N
7941238	7941119	c.652G>A/c.14209C>T	{"RYR1": {"c.652G>A": 1, "c.14209C>T": 1}}	\N
7941239	7941119	c.3166G>A/c.3166G>C	{"RYR1": {"c.3166G>A": 1, "c.3166G>C": 1}}	\N
7941240	7941119	c.1565A>G/c.6544A>T	{"RYR1": {"c.1565A>G": 1, "c.6544A>T": 1}}	\N
7941241	7941119	c.103T>C/c.7112A>G	{"RYR1": {"c.103T>C": 1, "c.7112A>G": 1}}	\N
7941242	7941119	c.5183C>T/c.14968A>G	{"RYR1": {"c.5183C>T": 1, "c.14968A>G": 1}}	\N
7941243	7941119	c.38T>G/c.4775C>T	{"RYR1": {"c.38T>G": 1, "c.4775C>T": 1}}	\N
7941244	7941119	c.7123G>A/c.12242C>T	{"RYR1": {"c.7123G>A": 1, "c.12242C>T": 1}}	\N
7941245	7941119	c.742G>A/c.8600T>A	{"RYR1": {"c.742G>A": 1, "c.8600T>A": 1}}	\N
7941246	7941119	c.1597C>T/c.14782A>G	{"RYR1": {"c.1597C>T": 1, "c.14782A>G": 1}}	\N
7941247	7941119	c.12064A>G/c.14918C>T	{"RYR1": {"c.12064A>G": 1, "c.14918C>T": 1}}	\N
7941248	7941119	c.12242C>T/c.14477C>T	{"RYR1": {"c.12242C>T": 1, "c.14477C>T": 1}}	\N
7941249	7941119	c.3166G>C/c.12533G>T	{"RYR1": {"c.3166G>C": 1, "c.12533G>T": 1}}	\N
7941250	7941119	c.7048G>A/c.12064A>G	{"RYR1": {"c.7048G>A": 1, "c.12064A>G": 1}}	\N
7941251	7941119	c.1565A>C/c.13990T>C	{"RYR1": {"c.1565A>C": 1, "c.13990T>C": 1}}	\N
7941252	7941119	c.742G>C/c.7355G>A	{"RYR1": {"c.742G>C": 1, "c.7355G>A": 1}}	\N
7941253	7941119	c.2654G>A/c.7007G>A	{"RYR1": {"c.2654G>A": 1, "c.7007G>A": 1}}	\N
7941254	7941119	c.742G>C/c.7355G>C	{"RYR1": {"c.742G>C": 1, "c.7355G>C": 1}}	\N
7941255	7941119	c.7076G>A/c.9797T>C	{"RYR1": {"c.7076G>A": 1, "c.9797T>C": 1}}	\N
7941256	7941119	c.1021G>C/c.14825G>T	{"RYR1": {"c.1021G>C": 1, "c.14825G>T": 1}}	\N
7941257	7941119	c.130C>T/c.7522C>G	{"RYR1": {"c.130C>T": 1, "c.7522C>G": 1}}	\N
7941258	7941119	c.7032G>C/c.11969G>T	{"RYR1": {"c.7032G>C": 1, "c.11969G>T": 1}}	\N
7941259	7941119	c.13918A>G/c.14539G>C	{"RYR1": {"c.13918A>G": 1, "c.14539G>C": 1}}	\N
7941260	7941119	c.3527C>T/c.7035C>A	{"RYR1": {"c.3527C>T": 1, "c.7035C>A": 1}}	\N
7941261	7941119	c.12700G>C/c.14509C>G	{"RYR1": {"c.12700G>C": 1, "c.14509C>G": 1}}	\N
7941262	7941119	c.533A>G/c.13990T>C	{"RYR1": {"c.533A>G": 1, "c.13990T>C": 1}}	\N
7941263	7941119	c.3166G>A/c.7300G>A	{"RYR1": {"c.3166G>A": 1, "c.7300G>A": 1}}	\N
7941264	7941119	c.38T>G/c.14817C>A	{"RYR1": {"c.38T>G": 1, "c.14817C>A": 1}}	\N
7941265	7941119	c.7048G>A/c.14509C>G	{"RYR1": {"c.7048G>A": 1, "c.14509C>G": 1}}	\N
7941266	7941119	c.7291G>A/c.13934G>A	{"RYR1": {"c.7291G>A": 1, "c.13934G>A": 1}}	\N
7941267	7941119	c.130C>T/c.7787C>T	{"RYR1": {"c.130C>T": 1, "c.7787C>T": 1}}	\N
7941268	7941119	c.7075C>T/c.7361G>A	{"RYR1": {"c.7075C>T": 1, "c.7361G>A": 1}}	\N
7941269	7941119	c.7210G>A/c.9310G>A	{"RYR1": {"c.7210G>A": 1, "c.9310G>A": 1}}	\N
7941270	7941119	c.1597C>A/c.9310G>A	{"RYR1": {"c.1597C>A": 1, "c.9310G>A": 1}}	\N
7941271	7941119	c.3172G>A/c.14627A>G	{"RYR1": {"c.3172G>A": 1, "c.14627A>G": 1}}	\N
7941272	7941119	c.2122G>A/c.7360C>T	{"RYR1": {"c.2122G>A": 1, "c.7360C>T": 1}}	\N
7941273	7941119	c.130C>T/c.13672C>T	{"RYR1": {"c.130C>T": 1, "c.13672C>T": 1}}	\N
7941274	7941119	c.11708G>A/c.14680G>A	{"RYR1": {"c.11708G>A": 1, "c.14680G>A": 1}}	\N
7941275	7941119	c.1615T>G/c.2122G>A	{"RYR1": {"c.1615T>G": 1, "c.2122G>A": 1}}	\N
7941276	7941119	c.1201C>G/c.7124G>C	{"RYR1": {"c.1201C>G": 1, "c.7124G>C": 1}}	\N
7941277	7941119	c.742G>C/c.8600T>A	{"RYR1": {"c.742G>C": 1, "c.8600T>A": 1}}	\N
7941278	7941119	c.493G>A/c.14627A>G	{"RYR1": {"c.493G>A": 1, "c.14627A>G": 1}}	\N
7941279	7941119	c.1840C>T/c.9850T>A	{"RYR1": {"c.1840C>T": 1, "c.9850T>A": 1}}	\N
7941280	7941119	c.14186A>C/c.14497C>T	{"RYR1": {"c.14186A>C": 1, "c.14497C>T": 1}}	\N
7941281	7941119	c.6349G>C/c.12532G>A	{"RYR1": {"c.6349G>C": 1, "c.12532G>A": 1}}	\N
7941282	7941119	c.6628G>T/c.7112A>G	{"RYR1": {"c.6628G>T": 1, "c.7112A>G": 1}}	\N
7941283	7941119	c.742G>C/c.7112A>G	{"RYR1": {"c.742G>C": 1, "c.7112A>G": 1}}	\N
7941284	7941119	c.7199A>G/c.14512C>G	{"RYR1": {"c.7199A>G": 1, "c.14512C>G": 1}}	\N
7941285	7941119	c.7304G>T/c.14567C>G	{"RYR1": {"c.7304G>T": 1, "c.14567C>G": 1}}	\N
7941286	7941119	c.3527C>T/c.14210G>A	{"RYR1": {"c.3527C>T": 1, "c.14210G>A": 1}}	\N
7941287	7941119	c.12398A>G/c.14210G>A	{"RYR1": {"c.12398A>G": 1, "c.14210G>A": 1}}	\N
7941288	7941119	c.6743G>A/c.7090T>G	{"RYR1": {"c.6743G>A": 1, "c.7090T>G": 1}}	\N
7941289	7941119	c.1202G>A/c.14186A>C	{"RYR1": {"c.1202G>A": 1, "c.14186A>C": 1}}	\N
7941290	7941119	c.130C>T/c.9649T>C	{"RYR1": {"c.130C>T": 1, "c.9649T>C": 1}}	\N
7941291	7941119	c.493G>A/c.14497C>T	{"RYR1": {"c.493G>A": 1, "c.14497C>T": 1}}	\N
7941292	7941119	c.625G>A/c.7007G>A	{"RYR1": {"c.625G>A": 1, "c.7007G>A": 1}}	\N
7941293	7941119	c.1459C>G/c.14512C>G	{"RYR1": {"c.1459C>G": 1, "c.14512C>G": 1}}	\N
7941294	7941119	c.14545G>A/c.14782A>G	{"RYR1": {"c.14545G>A": 1, "c.14782A>G": 1}}	\N
7941295	7941119	c.3667G>A/c.7358T>C	{"RYR1": {"c.3667G>A": 1, "c.7358T>C": 1}}	\N
7941296	7941119	c.7373G>T/c.13994_13995delTCinsCT	{"RYR1": {"c.7373G>T": 1, "c.13994_13995delTCinsCT": 1}}	\N
7941297	7941119	c.455C>A/c.7373G>T	{"RYR1": {"c.455C>A": 1, "c.7373G>T": 1}}	\N
7941298	7941119	c.7097C>G/c.11708G>A	{"RYR1": {"c.7097C>G": 1, "c.11708G>A": 1}}	\N
7941299	7941119	c.982C>T/c.14817C>A	{"RYR1": {"c.982C>T": 1, "c.14817C>A": 1}}	\N
7941300	7941119	c.7360C>T/c.8054C>T	{"RYR1": {"c.7360C>T": 1, "c.8054C>T": 1}}	\N
7941301	7941119	c.1589G>A/c.1597C>A	{"RYR1": {"c.1589G>A": 1, "c.1597C>A": 1}}	\N
7941302	7941119	c.7210G>A/c.11708G>A	{"RYR1": {"c.7210G>A": 1, "c.11708G>A": 1}}	\N
7941303	7941119	c.6488G>C/c.9499C>T	{"RYR1": {"c.6488G>C": 1, "c.9499C>T": 1}}	\N
7941304	7941119	c.455C>A/c.7373G>A	{"RYR1": {"c.455C>A": 1, "c.7373G>A": 1}}	\N
7941305	7941119	c.130C>T/c.12689T>G	{"RYR1": {"c.130C>T": 1, "c.12689T>G": 1}}	\N
7941306	7941119	c.7042_7044delGAG/c.8638G>A	{"RYR1": {"c.8638G>A": 1, "c.7042_7044delGAG": 1}}	\N
7941307	7941119	c.533A>G/c.9848G>A	{"RYR1": {"c.533A>G": 1, "c.9848G>A": 1}}	\N
7941308	7941119	c.6488G>A/c.7089C>G	{"RYR1": {"c.6488G>A": 1, "c.7089C>G": 1}}	\N
7941309	7941119	c.11969G>T/c.13994_13995delTCinsCT	{"RYR1": {"c.11969G>T": 1, "c.13994_13995delTCinsCT": 1}}	\N
7941310	7941119	c.10043G>A/c.14627A>G	{"RYR1": {"c.10043G>A": 1, "c.14627A>G": 1}}	\N
7941311	7941119	c.7372C>T/c.13672C>T	{"RYR1": {"c.7372C>T": 1, "c.13672C>T": 1}}	\N
7941312	7941119	c.11723A>T/c.14210G>A	{"RYR1": {"c.11723A>T": 1, "c.14210G>A": 1}}	\N
7941313	7941119	c.1201C>T/c.12355A>T	{"RYR1": {"c.1201C>T": 1, "c.12355A>T": 1}}	\N
7941314	7941119	c.742G>A/c.7112A>G	{"RYR1": {"c.742G>A": 1, "c.7112A>G": 1}}	\N
7941315	7941119	c.14449A>T/c.14497C>T	{"RYR1": {"c.14449A>T": 1, "c.14497C>T": 1}}	\N
7941316	7941119	c.1630G>T/c.14680G>A	{"RYR1": {"c.1630G>T": 1, "c.14680G>A": 1}}	\N
7941317	7941119	c.7361G>A/c.10042C>T	{"RYR1": {"c.7361G>A": 1, "c.10042C>T": 1}}	\N
7941318	7941119	c.130C>T/c.8188G>C	{"RYR1": {"c.130C>T": 1, "c.8188G>C": 1}}	\N
7941319	7941119	c.7035C>A/c.13918A>G	{"RYR1": {"c.7035C>A": 1, "c.13918A>G": 1}}	\N
7941320	7941119	c.9676G>C/c.14209C>T	{"RYR1": {"c.9676G>C": 1, "c.14209C>T": 1}}	\N
7941321	7941119	c.1589G>A/c.3095G>A	{"RYR1": {"c.1589G>A": 1, "c.3095G>A": 1}}	\N
7941322	7941119	c.1654C>T/c.7089C>G	{"RYR1": {"c.1654C>T": 1, "c.7089C>G": 1}}	\N
7941323	7941119	c.12700G>T/c.14449A>T	{"RYR1": {"c.12700G>T": 1, "c.14449A>T": 1}}	\N
7941324	7941119	c.6487C>T/c.6548G>A	{"RYR1": {"c.6487C>T": 1, "c.6548G>A": 1}}	\N
7941325	7941119	c.1654C>T/c.9499C>T	{"RYR1": {"c.1654C>T": 1, "c.9499C>T": 1}}	\N
7941326	7941119	c.7373G>A/c.8198G>A	{"RYR1": {"c.7373G>A": 1, "c.8198G>A": 1}}	\N
7941327	7941119	c.38T>G/c.7778G>A	{"RYR1": {"c.38T>G": 1, "c.7778G>A": 1}}	\N
7941328	7941119	c.1840C>T/c.9268G>A	{"RYR1": {"c.1840C>T": 1, "c.9268G>A": 1}}	\N
7941329	7941119	c.7123G>A/c.14002C>T	{"RYR1": {"c.7123G>A": 1, "c.14002C>T": 1}}	\N
7941330	7941119	c.7317G>C/c.14210G>A	{"RYR1": {"c.7317G>C": 1, "c.14210G>A": 1}}	\N
7941331	7941119	c.251C>T/c.1202G>T	{"RYR1": {"c.251C>T": 1, "c.1202G>T": 1}}	\N
7941332	7941119	c.3166G>C/c.10229C>A	{"RYR1": {"c.3166G>C": 1, "c.10229C>A": 1}}	\N
7941333	7941119	c.7090T>G/c.11518G>A	{"RYR1": {"c.7090T>G": 1, "c.11518G>A": 1}}	\N
7941334	7941119	c.251C>T/c.1202G>A	{"RYR1": {"c.251C>T": 1, "c.1202G>A": 1}}	\N
7941335	7941119	c.7123G>A/c.11518G>A	{"RYR1": {"c.7123G>A": 1, "c.11518G>A": 1}}	\N
7941336	7941119	c.467G>A/c.6487C>T	{"RYR1": {"c.467G>A": 1, "c.6487C>T": 1}}	\N
7941337	7941119	c.6488G>A/c.9499C>T	{"RYR1": {"c.6488G>A": 1, "c.9499C>T": 1}}	\N
7941338	7941119	c.6487C>T/c.11120G>T	{"RYR1": {"c.6487C>T": 1, "c.11120G>T": 1}}	\N
7941339	7941119	c.742G>A/c.9356G>A	{"RYR1": {"c.742G>A": 1, "c.9356G>A": 1}}	\N
7941340	7941119	c.6488G>C/c.7089C>G	{"RYR1": {"c.6488G>C": 1, "c.7089C>G": 1}}	\N
7941341	7941119	c.3656A>C/c.6612C>G	{"RYR1": {"c.3656A>C": 1, "c.6612C>G": 1}}	\N
7941342	7941119	c.7373G>A/c.14639T>C	{"RYR1": {"c.7373G>A": 1, "c.14639T>C": 1}}	\N
7941343	7941119	c.533A>G/c.6544A>T	{"RYR1": {"c.533A>G": 1, "c.6544A>T": 1}}	\N
7941344	7941119	c.1630G>T/c.2996G>A	{"RYR1": {"c.1630G>T": 1, "c.2996G>A": 1}}	\N
7941345	7941119	c.7112A>G/c.7522C>T	{"RYR1": {"c.7112A>G": 1, "c.7522C>T": 1}}	\N
7941346	7941119	c.742G>C/c.6635T>A	{"RYR1": {"c.742G>C": 1, "c.6635T>A": 1}}	\N
7941347	7941119	c.178G>A/c.6628G>T	{"RYR1": {"c.178G>A": 1, "c.6628G>T": 1}}	\N
7941348	7941119	c.7372C>T/c.11953T>C	{"RYR1": {"c.7372C>T": 1, "c.11953T>C": 1}}	\N
7941349	7941119	c.8054C>T/c.14497C>T	{"RYR1": {"c.8054C>T": 1, "c.14497C>T": 1}}	\N
7941350	7941119	c.1202G>A/c.13702C>G	{"RYR1": {"c.1202G>A": 1, "c.13702C>G": 1}}	\N
7941351	7941119	c.742G>A/c.14364+1G>T	{"RYR1": {"c.742G>A": 1, "c.14364+1G>T": 1}}	\N
7941352	7941119	c.6628G>T/c.8054C>T	{"RYR1": {"c.6628G>T": 1, "c.8054C>T": 1}}	\N
7941353	7941119	c.7123G>A/c.14582G>A	{"RYR1": {"c.7123G>A": 1, "c.14582G>A": 1}}	\N
7941354	7941119	c.7090T>G/c.14002C>T	{"RYR1": {"c.7090T>G": 1, "c.14002C>T": 1}}	\N
7941355	7941119	c.7282G>A/c.12121C>T	{"RYR1": {"c.7282G>A": 1, "c.12121C>T": 1}}	\N
7941356	7941119	c.6387C>G/c.11947C>T	{"RYR1": {"c.6387C>G": 1, "c.11947C>T": 1}}	\N
7941357	7941119	c.8026C>T/c.14201G>A	{"RYR1": {"c.8026C>T": 1, "c.14201G>A": 1}}	\N
7941358	7941119	c.2654G>A/c.6487C>T	{"RYR1": {"c.2654G>A": 1, "c.6487C>T": 1}}	\N
7941359	7941119	c.178G>A/c.5183C>T	{"RYR1": {"c.178G>A": 1, "c.5183C>T": 1}}	\N
7941360	7941119	c.103T>C/c.14197T>G	{"RYR1": {"c.103T>C": 1, "c.14197T>G": 1}}	\N
7941361	7941119	c.7304G>A/c.11086G>C	{"RYR1": {"c.7304G>A": 1, "c.11086G>C": 1}}	\N
7941362	7941119	c.533A>G/c.641C>T	{"RYR1": {"c.533A>G": 1, "c.641C>T": 1}}	\N
7941363	7941119	c.1565A>C/c.8527T>C	{"RYR1": {"c.1565A>C": 1, "c.8527T>C": 1}}	\N
7941364	7941119	c.51_53del/c.14545G>A	{"RYR1": {"c.14545G>A": 1, "c.51_53del": 1}}	\N
7941365	7941119	c.2050G>C/c.6488G>T	{"RYR1": {"c.2050G>C": 1, "c.6488G>T": 1}}	\N
7941366	7941119	c.1201C>A/c.7124G>C	{"RYR1": {"c.1201C>A": 1, "c.7124G>C": 1}}	\N
7941367	7941119	c.103T>C/c.9152G>A	{"RYR1": {"c.103T>C": 1, "c.9152G>A": 1}}	\N
7941368	7941119	c.1597C>T/c.1834G>C	{"RYR1": {"c.1597C>T": 1, "c.1834G>C": 1}}	\N
7941369	7941119	c.677T>A/c.7123G>A	{"RYR1": {"c.677T>A": 1, "c.7123G>A": 1}}	\N
7941370	7941119	c.1654C>T/c.9152G>A	{"RYR1": {"c.1654C>T": 1, "c.9152G>A": 1}}	\N
7941371	7941119	c.5183C>T/c.6640G>A	{"RYR1": {"c.5183C>T": 1, "c.6640G>A": 1}}	\N
7941372	7941119	c.7304G>T/c.8189A>G	{"RYR1": {"c.7304G>T": 1, "c.8189A>G": 1}}	\N
7941373	7941119	c.742G>C/c.9356G>A	{"RYR1": {"c.742G>C": 1, "c.9356G>A": 1}}	\N
7941374	7941119	c.6349G>C/c.12398A>G	{"RYR1": {"c.6349G>C": 1, "c.12398A>G": 1}}	\N
7941375	7941119	c.1209C>G/c.1654C>T	{"RYR1": {"c.1209C>G": 1, "c.1654C>T": 1}}	\N
7941376	7941119	c.2050G>C/c.6488G>A	{"RYR1": {"c.2050G>C": 1, "c.6488G>A": 1}}	\N
7941377	7941119	c.130C>T/c.12383C>T	{"RYR1": {"c.130C>T": 1, "c.12383C>T": 1}}	\N
7941378	7941119	c.2050G>C/c.6488G>C	{"RYR1": {"c.2050G>C": 1, "c.6488G>C": 1}}	\N
7941379	7941119	c.6478G>A/c.6838G>A	{"RYR1": {"c.6478G>A": 1, "c.6838G>A": 1}}	\N
7941380	7941119	c.680A>T/c.7282G>A	{"RYR1": {"c.680A>T": 1, "c.7282G>A": 1}}	\N
7941381	7941119	c.1654C>T/c.14197T>G	{"RYR1": {"c.1654C>T": 1, "c.14197T>G": 1}}	\N
7941382	7941119	c.479A>G/c.529C>T	{"RYR1": {"c.479A>G": 1, "c.529C>T": 1}}	\N
7941383	7941119	c.1202G>T/c.7018T>C	{"RYR1": {"c.1202G>T": 1, "c.7018T>C": 1}}	\N
7941384	7941119	c.178G>A/c.7304G>T	{"RYR1": {"c.178G>A": 1, "c.7304G>T": 1}}	\N
7941385	7941119	c.4775C>T/c.11708G>A	{"RYR1": {"c.4775C>T": 1, "c.11708G>A": 1}}	\N
7941386	7941119	c.3667G>A/c.14803G>A	{"RYR1": {"c.3667G>A": 1, "c.14803G>A": 1}}	\N
7941387	7941119	c.528G>T/c.1201C>T	{"RYR1": {"c.528G>T": 1, "c.1201C>T": 1}}	\N
7941388	7941119	c.533A>G/c.7210G>A	{"RYR1": {"c.533A>G": 1, "c.7210G>A": 1}}	\N
7941389	7941119	c.7354C>T/c.7487C>T	{"RYR1": {"c.7354C>T": 1, "c.7487C>T": 1}}	\N
7941390	7941119	c.7879G>C/c.14782A>G	{"RYR1": {"c.7879G>C": 1, "c.14782A>G": 1}}	\N
7941391	7941119	c.487C>T/c.5441T>A	{"RYR1": {"c.487C>T": 1, "c.5441T>A": 1}}	\N
7941392	7941119	c.38T>G/c.6847A>C	{"RYR1": {"c.38T>G": 1, "c.6847A>C": 1}}	\N
7941393	7941119	c.6488G>C/c.13990T>C	{"RYR1": {"c.6488G>C": 1, "c.13990T>C": 1}}	\N
7941394	7941119	c.13673G>A/c.14545G>A	{"RYR1": {"c.13673G>A": 1, "c.14545G>A": 1}}	\N
7941395	7941119	c.742G>C/c.13673G>A	{"RYR1": {"c.742G>C": 1, "c.13673G>A": 1}}	\N
7941396	7941119	c.1565A>C/c.8654C>G	{"RYR1": {"c.1565A>C": 1, "c.8654C>G": 1}}	\N
7941397	7941119	c.9310G>A/c.14567C>G	{"RYR1": {"c.9310G>A": 1, "c.14567C>G": 1}}	\N
7941398	7941119	c.6612C>G/c.12064A>G	{"RYR1": {"c.6612C>G": 1, "c.12064A>G": 1}}	\N
7941399	7941119	c.7084G>A/c.8638G>A	{"RYR1": {"c.7084G>A": 1, "c.8638G>A": 1}}	\N
7941400	7941119	c.1615T>G/c.13994_13995delTCinsCT	{"RYR1": {"c.1615T>G": 1, "c.13994_13995delTCinsCT": 1}}	\N
7941401	7941119	c.641C>T/c.7007G>A	{"RYR1": {"c.641C>T": 1, "c.7007G>A": 1}}	\N
7941402	7941119	c.251C>T/c.14209C>T	{"RYR1": {"c.251C>T": 1, "c.14209C>T": 1}}	\N
7941403	7941119	c.12553G>A/c.14497C>T	{"RYR1": {"c.12553G>A": 1, "c.14497C>T": 1}}	\N
7941404	7941119	c.1100G>A/c.7043A>G	{"RYR1": {"c.1100G>A": 1, "c.7043A>G": 1}}	\N
7941405	7941119	c.1597C>T/c.14817C>A	{"RYR1": {"c.1597C>T": 1, "c.14817C>A": 1}}	\N
7941406	7941119	c.6488G>T/c.9356G>A	{"RYR1": {"c.6488G>T": 1, "c.9356G>A": 1}}	\N
7941407	7941119	c.12553G>A/c.14627A>G	{"RYR1": {"c.12553G>A": 1, "c.14627A>G": 1}}	\N
7941408	7941119	c.178G>A/c.7304G>A	{"RYR1": {"c.178G>A": 1, "c.7304G>A": 1}}	\N
7941409	7941119	c.947G>T/c.7354C>T	{"RYR1": {"c.947G>T": 1, "c.7354C>T": 1}}	\N
7941410	7941119	c.11416G>A/c.12149C>A	{"RYR1": {"c.11416G>A": 1, "c.12149C>A": 1}}	\N
7941411	7941119	c.455C>A/c.7361G>A	{"RYR1": {"c.455C>A": 1, "c.7361G>A": 1}}	\N
7941412	7941119	c.455C>A/c.14497C>T	{"RYR1": {"c.455C>A": 1, "c.14497C>T": 1}}	\N
7941413	7941119	c.1021G>C/c.13918A>G	{"RYR1": {"c.1021G>C": 1, "c.13918A>G": 1}}	\N
7941414	7941119	c.497A>G/c.1841G>T	{"RYR1": {"c.497A>G": 1, "c.1841G>T": 1}}	\N
7941415	7941119	c.7522C>T/c.14471T>C	{"RYR1": {"c.7522C>T": 1, "c.14471T>C": 1}}	\N
7941416	7941119	c.1589G>A/c.12028G>A	{"RYR1": {"c.1589G>A": 1, "c.12028G>A": 1}}	\N
7941417	7941119	c.4775C>T/c.9310G>A	{"RYR1": {"c.4775C>T": 1, "c.9310G>A": 1}}	\N
7941418	7941119	c.1565A>G/c.9499C>T	{"RYR1": {"c.1565A>G": 1, "c.9499C>T": 1}}	\N
7941419	7941119	c.487C>T/c.6304G>C	{"RYR1": {"c.487C>T": 1, "c.6304G>C": 1}}	\N
7941420	7941119	c.1202G>A/c.6757C>T	{"RYR1": {"c.1202G>A": 1, "c.6757C>T": 1}}	\N
7941421	7941119	c.6037A>C/c.8026C>T	{"RYR1": {"c.6037A>C": 1, "c.8026C>T": 1}}	\N
7941422	7941119	c.6387C>G/c.12553G>A	{"RYR1": {"c.6387C>G": 1, "c.12553G>A": 1}}	\N
7941423	7941119	c.7373G>T/c.12848A>T	{"RYR1": {"c.7373G>T": 1, "c.12848A>T": 1}}	\N
7941424	7941119	c.7310C>T/c.9868G>A	{"RYR1": {"c.7310C>T": 1, "c.9868G>A": 1}}	\N
7941425	7941119	c.13505A>G/c.14210G>A	{"RYR1": {"c.13505A>G": 1, "c.14210G>A": 1}}	\N
7941426	7941119	c.1615T>C/c.6377G>A	{"RYR1": {"c.1615T>C": 1, "c.6377G>A": 1}}	\N
7941427	7941119	c.7358T>C/c.7777C>G	{"RYR1": {"c.7358T>C": 1, "c.7777C>G": 1}}	\N
7941428	7941119	c.5440A>G/c.14477C>T	{"RYR1": {"c.5440A>G": 1, "c.14477C>T": 1}}	\N
7941429	7941119	c.7373G>T/c.11813G>A	{"RYR1": {"c.7373G>T": 1, "c.11813G>A": 1}}	\N
7941430	7941119	c.7084G>A/c.14558C>T	{"RYR1": {"c.7084G>A": 1, "c.14558C>T": 1}}	\N
7941431	7941119	c.7097C>G/c.9310G>A	{"RYR1": {"c.7097C>G": 1, "c.9310G>A": 1}}	\N
7941432	7941119	c.7372C>T/c.7522C>G	{"RYR1": {"c.7372C>T": 1, "c.7522C>G": 1}}	\N
7941433	7941119	c.12700G>T/c.14509C>G	{"RYR1": {"c.12700G>T": 1, "c.14509C>G": 1}}	\N
7941434	7941119	c.742G>C/c.9152G>A	{"RYR1": {"c.742G>C": 1, "c.9152G>A": 1}}	\N
7941435	7941119	c.487C>T/c.8198G>A	{"RYR1": {"c.487C>T": 1, "c.8198G>A": 1}}	\N
7941436	7941119	c.529C>T/c.7778G>A	{"RYR1": {"c.529C>T": 1, "c.7778G>A": 1}}	\N
7941437	7941119	c.103T>C/c.497A>G	{"RYR1": {"c.103T>C": 1, "c.497A>G": 1}}	\N
7941438	7941119	c.14509C>G/c.14918C>T	{"RYR1": {"c.14509C>G": 1, "c.14918C>T": 1}}	\N
7941439	7941119	c.7048G>A/c.7385C>T	{"RYR1": {"c.7048G>A": 1, "c.7385C>T": 1}}	\N
7941440	7941119	c.7310C>T/c.14186A>C	{"RYR1": {"c.7310C>T": 1, "c.14186A>C": 1}}	\N
7941441	7941119	c.487C>T/c.7292A>T	{"RYR1": {"c.487C>T": 1, "c.7292A>T": 1}}	\N
7941442	7941119	c.7879G>C/c.14817C>A	{"RYR1": {"c.7879G>C": 1, "c.14817C>A": 1}}	\N
7941443	7941119	c.1144C>A/c.6617C>G	{"RYR1": {"c.1144C>A": 1, "c.6617C>G": 1}}	\N
7941444	7941119	c.1841G>T/c.5033A>G	{"RYR1": {"c.1841G>T": 1, "c.5033A>G": 1}}	\N
7941445	7941119	c.1144C>A/c.6617C>T	{"RYR1": {"c.1144C>A": 1, "c.6617C>T": 1}}	\N
7941446	7941119	c.7522C>T/c.14879T>A	{"RYR1": {"c.7522C>T": 1, "c.14879T>A": 1}}	\N
7941447	7941119	c.5033A>G/c.7372C>T	{"RYR1": {"c.5033A>G": 1, "c.7372C>T": 1}}	\N
7941448	7941119	c.7007G>A/c.7099G>A	{"RYR1": {"c.7007G>A": 1, "c.7099G>A": 1}}	\N
7941449	7941119	c.97A>G/c.10043G>A	{"RYR1": {"c.97A>G": 1, "c.10043G>A": 1}}	\N
7941450	7941119	c.7354C>T/c.9758T>C	{"RYR1": {"c.7354C>T": 1, "c.9758T>C": 1}}	\N
7941451	7941119	c.1201C>T/c.11126C>T	{"RYR1": {"c.1201C>T": 1, "c.11126C>T": 1}}	\N
7941452	7941119	c.1630G>T/c.5341T>C	{"RYR1": {"c.1630G>T": 1, "c.5341T>C": 1}}	\N
7941453	7941119	c.7354C>T/c.12689T>G	{"RYR1": {"c.7354C>T": 1, "c.12689T>G": 1}}	\N
7941454	7941119	c.3656A>C/c.14918C>T	{"RYR1": {"c.3656A>C": 1, "c.14918C>T": 1}}	\N
7941455	7941119	c.982C>T/c.5024T>C	{"RYR1": {"c.982C>T": 1, "c.5024T>C": 1}}	\N
7941456	7941119	c.463C>A/c.6388G>A	{"RYR1": {"c.463C>A": 1, "c.6388G>A": 1}}	\N
7941457	7941119	c.7076G>A/c.11132C>T	{"RYR1": {"c.7076G>A": 1, "c.11132C>T": 1}}	\N
7941458	7941119	c.6488G>A/c.8527T>C	{"RYR1": {"c.6488G>A": 1, "c.8527T>C": 1}}	\N
7941459	7941119	c.1201C>G/c.14477C>T	{"RYR1": {"c.1201C>G": 1, "c.14477C>T": 1}}	\N
7941460	7941119	c.1201C>A/c.6387C>G	{"RYR1": {"c.1201C>A": 1, "c.6387C>G": 1}}	\N
7941461	7941119	c.6628G>T/c.13673G>A	{"RYR1": {"c.6628G>T": 1, "c.13673G>A": 1}}	\N
7941462	7941119	c.533A>G/c.9499C>T	{"RYR1": {"c.533A>G": 1, "c.9499C>T": 1}}	\N
7941463	7941119	c.1201C>T/c.7292A>T	{"RYR1": {"c.1201C>T": 1, "c.7292A>T": 1}}	\N
7941464	7941119	c.2122G>A/c.7036G>A	{"RYR1": {"c.2122G>A": 1, "c.7036G>A": 1}}	\N
7941465	7941119	c.14477C>T/c.14814C>G	{"RYR1": {"c.14477C>T": 1, "c.14814C>G": 1}}	\N
7941466	7941119	c.7032G>C/c.7304G>T	{"RYR1": {"c.7032G>C": 1, "c.7304G>T": 1}}	\N
7941467	7941119	c.7099G>A/c.9310G>A	{"RYR1": {"c.7099G>A": 1, "c.9310G>A": 1}}	\N
7941468	7941119	c.9499C>T/c.11969G>T	{"RYR1": {"c.9499C>T": 1, "c.11969G>T": 1}}	\N
7941469	7941119	c.1630G>T/c.3095G>A	{"RYR1": {"c.1630G>T": 1, "c.3095G>A": 1}}	\N
7941470	7941119	c.742G>A/c.8054C>T	{"RYR1": {"c.742G>A": 1, "c.8054C>T": 1}}	\N
7941471	7941119	c.1565A>G/c.8654C>G	{"RYR1": {"c.1565A>G": 1, "c.8654C>G": 1}}	\N
7941472	7941119	c.488G>T/c.7771C>T	{"RYR1": {"c.488G>T": 1, "c.7771C>T": 1}}	\N
7941473	7941119	c.14197T>G/c.14918C>T	{"RYR1": {"c.14197T>G": 1, "c.14918C>T": 1}}	\N
7941474	7941119	c.178G>T/c.5183C>T	{"RYR1": {"c.178G>T": 1, "c.5183C>T": 1}}	\N
7941475	7941119	c.463C>A/c.496G>A	{"RYR1": {"c.463C>A": 1, "c.496G>A": 1}}	\N
7941476	7941119	c.6487C>T/c.14458G>T	{"RYR1": {"c.6487C>T": 1, "c.14458G>T": 1}}	\N
7941477	7941119	c.742G>A/c.9152G>A	{"RYR1": {"c.742G>A": 1, "c.9152G>A": 1}}	\N
7941478	7941119	c.497A>G/c.529C>T	{"RYR1": {"c.497A>G": 1, "c.529C>T": 1}}	\N
7941479	7941119	c.1589G>A/c.14680G>A	{"RYR1": {"c.1589G>A": 1, "c.14680G>A": 1}}	\N
7941480	7941119	c.5440A>G/c.11969G>T	{"RYR1": {"c.5440A>G": 1, "c.11969G>T": 1}}	\N
7941481	7941119	c.533A>G/c.7089C>G	{"RYR1": {"c.533A>G": 1, "c.7089C>G": 1}}	\N
7941482	7941119	c.7372C>T/c.7787C>T	{"RYR1": {"c.7372C>T": 1, "c.7787C>T": 1}}	\N
7941483	7941119	c.7084G>A/c.10750G>C	{"RYR1": {"c.7084G>A": 1, "c.10750G>C": 1}}	\N
7941484	7941119	c.7361G>A/c.7760A>G	{"RYR1": {"c.7361G>A": 1, "c.7760A>G": 1}}	\N
7941485	7941119	c.7372C>T/c.7487C>T	{"RYR1": {"c.7372C>T": 1, "c.7487C>T": 1}}	\N
7941486	7941119	c.2537C>T/c.12149C>A	{"RYR1": {"c.2537C>T": 1, "c.12149C>A": 1}}	\N
7941487	7941119	c.6487C>T/c.14458G>A	{"RYR1": {"c.6487C>T": 1, "c.14458G>A": 1}}	\N
7941488	7941119	c.1202G>A/c.14524G>A	{"RYR1": {"c.1202G>A": 1, "c.14524G>A": 1}}	\N
7941489	7941119	c.533A>C/c.1565A>C	{"RYR1": {"c.533A>C": 1, "c.1565A>C": 1}}	\N
7941490	7941119	c.1654C>T/c.8600T>A	{"RYR1": {"c.1654C>T": 1, "c.8600T>A": 1}}	\N
7941491	7941119	c.652G>A/c.1201C>T	{"RYR1": {"c.652G>A": 1, "c.1201C>T": 1}}	\N
7941492	7941119	c.529C>T/c.14817C>A	{"RYR1": {"c.529C>T": 1, "c.14817C>A": 1}}	\N
7941493	7941119	c.6640G>A/c.7358T>C	{"RYR1": {"c.6640G>A": 1, "c.7358T>C": 1}}	\N
7941494	7941119	c.6640G>A/c.14803G>A	{"RYR1": {"c.6640G>A": 1, "c.14803G>A": 1}}	\N
7941495	7941119	c.529C>T/c.680A>T	{"RYR1": {"c.529C>T": 1, "c.680A>T": 1}}	\N
7941496	7941119	c.5033A>G/c.7360C>T	{"RYR1": {"c.5033A>G": 1, "c.7360C>T": 1}}	\N
7941497	7941119	c.97A>G/c.7075C>T	{"RYR1": {"c.97A>G": 1, "c.7075C>T": 1}}	\N
7941498	7941119	c.742G>C/c.8054C>T	{"RYR1": {"c.742G>C": 1, "c.8054C>T": 1}}	\N
7941499	7941119	c.7310C>T/c.10556C>T	{"RYR1": {"c.7310C>T": 1, "c.10556C>T": 1}}	\N
7941500	7941119	c.6612C>G/c.14449A>T	{"RYR1": {"c.6612C>G": 1, "c.14449A>T": 1}}	\N
7941501	7941119	c.1202G>T/c.7771C>T	{"RYR1": {"c.1202G>T": 1, "c.7771C>T": 1}}	\N
7941502	7941119	c.533A>C/c.1565A>G	{"RYR1": {"c.533A>C": 1, "c.1565A>G": 1}}	\N
7941503	7941119	c.529C>T/c.14693T>C	{"RYR1": {"c.529C>T": 1, "c.14693T>C": 1}}	\N
7941504	7941119	c.6640G>A/c.7282G>A	{"RYR1": {"c.6640G>A": 1, "c.7282G>A": 1}}	\N
7941505	7941119	c.6377G>A/c.7522C>T	{"RYR1": {"c.6377G>A": 1, "c.7522C>T": 1}}	\N
7941506	7941119	c.487C>T/c.2122G>A	{"RYR1": {"c.487C>T": 1, "c.2122G>A": 1}}	\N
7941507	7941119	c.2122G>A/c.7048G>A	{"RYR1": {"c.2122G>A": 1, "c.7048G>A": 1}}	\N
7941508	7941119	c.1459C>G/c.6387C>G	{"RYR1": {"c.1459C>G": 1, "c.6387C>G": 1}}	\N
7941509	7941119	c.1411C>T/c.6612C>G	{"RYR1": {"c.1411C>T": 1, "c.6612C>G": 1}}	\N
7941510	7941119	c.7291G>A/c.14201G>A	{"RYR1": {"c.7291G>A": 1, "c.14201G>A": 1}}	\N
7941511	7941119	c.1630G>T/c.12028G>A	{"RYR1": {"c.1630G>T": 1, "c.12028G>A": 1}}	\N
7941512	7941119	c.6387C>G/c.7073T>A	{"RYR1": {"c.6387C>G": 1, "c.7073T>A": 1}}	\N
7941513	7941119	c.6635T>A/c.7042_7044delGAG	{"RYR1": {"c.6635T>A": 1, "c.7042_7044delGAG": 1}}	\N
7941514	7941119	c.7358T>C/c.9797T>C	{"RYR1": {"c.7358T>C": 1, "c.9797T>C": 1}}	\N
7941515	7941119	c.3166G>A/c.7360C>T	{"RYR1": {"c.3166G>A": 1, "c.7360C>T": 1}}	\N
7941516	7941119	c.5024T>C/c.7043A>G	{"RYR1": {"c.5024T>C": 1, "c.7043A>G": 1}}	\N
7941517	7941119	c.488G>T/c.7771C>G	{"RYR1": {"c.488G>T": 1, "c.7771C>G": 1}}	\N
7941518	7941119	c.1202G>A/c.1453A>G	{"RYR1": {"c.1202G>A": 1, "c.1453A>G": 1}}	\N
7941519	7941119	c.528G>T/c.12149C>A	{"RYR1": {"c.528G>T": 1, "c.12149C>A": 1}}	\N
7941520	7941119	c.6743G>A/c.7036G>A	{"RYR1": {"c.6743G>A": 1, "c.7036G>A": 1}}	\N
7941521	7941119	c.12383C>T/c.14512C>G	{"RYR1": {"c.12383C>T": 1, "c.14512C>G": 1}}	\N
7941522	7941119	c.5341T>C/c.9310G>A	{"RYR1": {"c.5341T>C": 1, "c.9310G>A": 1}}	\N
7941523	7941119	c.1202G>T/c.7771C>G	{"RYR1": {"c.1202G>T": 1, "c.7771C>G": 1}}	\N
7941524	7941119	c.103T>C/c.7355G>C	{"RYR1": {"c.103T>C": 1, "c.7355G>C": 1}}	\N
7941525	7941119	c.97A>G/c.11126C>T	{"RYR1": {"c.97A>G": 1, "c.11126C>T": 1}}	\N
7941526	7941119	c.103T>C/c.7355G>A	{"RYR1": {"c.103T>C": 1, "c.7355G>A": 1}}	\N
7941527	7941119	c.7760A>G/c.12700G>T	{"RYR1": {"c.7760A>G": 1, "c.12700G>T": 1}}	\N
7941528	7941119	c.6628G>T/c.11958C>G	{"RYR1": {"c.6628G>T": 1, "c.11958C>G": 1}}	\N
7941529	7941119	c.7360C>T/c.11958C>G	{"RYR1": {"c.7360C>T": 1, "c.11958C>G": 1}}	\N
7941530	7941119	c.4763C>T/c.6487C>T	{"RYR1": {"c.4763C>T": 1, "c.6487C>T": 1}}	\N
7941531	7941119	c.13760C>T/c.14918C>T	{"RYR1": {"c.13760C>T": 1, "c.14918C>T": 1}}	\N
7941532	7941119	c.467G>A/c.7007G>A	{"RYR1": {"c.467G>A": 1, "c.7007G>A": 1}}	\N
7941533	7941119	c.533A>G/c.14197T>G	{"RYR1": {"c.533A>G": 1, "c.14197T>G": 1}}	\N
7941534	7941119	c.14497C>T/c.14567C>G	{"RYR1": {"c.14497C>T": 1, "c.14567C>G": 1}}	\N
7941535	7941119	c.6349G>C/c.12242C>T	{"RYR1": {"c.6349G>C": 1, "c.12242C>T": 1}}	\N
7941536	7941119	c.12115A>T/c.14497C>T	{"RYR1": {"c.12115A>T": 1, "c.14497C>T": 1}}	\N
7941537	7941119	c.10750G>C/c.14539G>C	{"RYR1": {"c.10750G>C": 1, "c.14539G>C": 1}}	\N
7941538	7941119	c.7076G>A/c.8729C>T	{"RYR1": {"c.7076G>A": 1, "c.8729C>T": 1}}	\N
7941539	7941119	c.6349G>C/c.13760C>T	{"RYR1": {"c.6349G>C": 1, "c.13760C>T": 1}}	\N
7941540	7941119	c.7304G>T/c.12121C>T	{"RYR1": {"c.7304G>T": 1, "c.12121C>T": 1}}	\N
7941541	7941119	c.7310C>T/c.14509C>G	{"RYR1": {"c.7310C>T": 1, "c.14509C>G": 1}}	\N
7941542	7941119	c.7018T>C/c.14545G>A	{"RYR1": {"c.7018T>C": 1, "c.14545G>A": 1}}	\N
7941543	7941119	c.6838G>A/c.14879T>A	{"RYR1": {"c.6838G>A": 1, "c.14879T>A": 1}}	\N
7941544	7941119	c.1201C>T/c.8198G>A	{"RYR1": {"c.1201C>T": 1, "c.8198G>A": 1}}	\N
7941545	7941119	c.7112A>G/c.7354C>T	{"RYR1": {"c.7112A>G": 1, "c.7354C>T": 1}}	\N
7941546	7941119	c.7007G>A/c.7771C>G	{"RYR1": {"c.7007G>A": 1, "c.7771C>G": 1}}	\N
7941547	7941119	c.12149C>A/c.12383C>T	{"RYR1": {"c.12149C>A": 1, "c.12383C>T": 1}}	\N
7941548	7941119	c.2122G>A/c.3166G>C	{"RYR1": {"c.2122G>A": 1, "c.3166G>C": 1}}	\N
7941549	7941119	c.1422G>T/c.6487C>T	{"RYR1": {"c.1422G>T": 1, "c.6487C>T": 1}}	\N
7941550	7941119	c.7354C>T/c.13672C>T	{"RYR1": {"c.7354C>T": 1, "c.13672C>T": 1}}	\N
7941551	7941119	c.1201C>A/c.14477C>T	{"RYR1": {"c.1201C>A": 1, "c.14477C>T": 1}}	\N
7941552	7941119	c.463C>A/c.14968A>G	{"RYR1": {"c.463C>A": 1, "c.14968A>G": 1}}	\N
7941553	7941119	c.1201C>G/c.6387C>G	{"RYR1": {"c.1201C>G": 1, "c.6387C>G": 1}}	\N
7941554	7941119	c.7879G>C/c.14693T>C	{"RYR1": {"c.7879G>C": 1, "c.14693T>C": 1}}	\N
7941555	7941119	c.6488G>C/c.8527T>C	{"RYR1": {"c.6488G>C": 1, "c.8527T>C": 1}}	\N
7941556	7941119	c.1598G>A/c.7523G>A	{"RYR1": {"c.1598G>A": 1, "c.7523G>A": 1}}	\N
7941557	7941119	c.6743G>A/c.7048G>A	{"RYR1": {"c.6743G>A": 1, "c.7048G>A": 1}}	\N
7941558	7941119	c.7007G>A/c.7771C>T	{"RYR1": {"c.7007G>A": 1, "c.7771C>T": 1}}	\N
7941559	7941119	c.455C>A/c.11315G>A	{"RYR1": {"c.455C>A": 1, "c.11315G>A": 1}}	\N
7941560	7941119	c.1411C>T/c.7879G>C	{"RYR1": {"c.1411C>T": 1, "c.7879G>C": 1}}	\N
7941561	7941119	c.982C>T/c.14782A>G	{"RYR1": {"c.982C>T": 1, "c.14782A>G": 1}}	\N
7941562	7941119	c.5132A>G/c.6502G>A	{"RYR1": {"c.5132A>G": 1, "c.6502G>A": 1}}	\N
7941563	7941119	c.5033A>G/c.7090T>G	{"RYR1": {"c.5033A>G": 1, "c.7090T>G": 1}}	\N
7941564	7941119	c.5033A>G/c.14497C>T	{"RYR1": {"c.5033A>G": 1, "c.14497C>T": 1}}	\N
7941565	7941119	c.529C>T/c.5024T>C	{"RYR1": {"c.529C>T": 1, "c.5024T>C": 1}}	\N
7941566	7941119	c.6612C>G/c.7385C>T	{"RYR1": {"c.6612C>G": 1, "c.7385C>T": 1}}	\N
7941567	7941119	c.488G>T/c.13918A>G	{"RYR1": {"c.488G>T": 1, "c.13918A>G": 1}}	\N
7941568	7941119	c.7300G>A/c.11723A>T	{"RYR1": {"c.7300G>A": 1, "c.11723A>T": 1}}	\N
7941569	7941119	c.97A>G/c.12355A>T	{"RYR1": {"c.97A>G": 1, "c.12355A>T": 1}}	\N
7941570	7941119	c.7124G>C/c.7385C>T	{"RYR1": {"c.7124G>C": 1, "c.7385C>T": 1}}	\N
7941571	7941119	c.4747C>T/c.7035C>A	{"RYR1": {"c.4747C>T": 1, "c.7035C>A": 1}}	\N
7941572	7941119	c.7042_7044delGAG/c.7385C>T	{"RYR1": {"c.7385C>T": 1, "c.7042_7044delGAG": 1}}	\N
7941573	7941119	c.1202G>A/c.3418C>T	{"RYR1": {"c.1202G>A": 1, "c.3418C>T": 1}}	\N
7941574	7941119	c.7373G>T/c.14639T>C	{"RYR1": {"c.7373G>T": 1, "c.14639T>C": 1}}	\N
7941575	7941119	c.1475G>A/c.6617C>T	{"RYR1": {"c.1475G>A": 1, "c.6617C>T": 1}}	\N
7941576	7941119	c.7291G>A/c.10043G>A	{"RYR1": {"c.7291G>A": 1, "c.10043G>A": 1}}	\N
7941577	7941119	c.5341T>C/c.7043A>G	{"RYR1": {"c.5341T>C": 1, "c.7043A>G": 1}}	\N
7941578	7941119	c.982C>T/c.7778G>A	{"RYR1": {"c.982C>T": 1, "c.7778G>A": 1}}	\N
7941579	7941119	c.1144C>A/c.7522C>T	{"RYR1": {"c.1144C>A": 1, "c.7522C>T": 1}}	\N
7941580	7941119	c.13672C>T/c.14918C>T	{"RYR1": {"c.13672C>T": 1, "c.14918C>T": 1}}	\N
7941581	7941119	c.7361G>A/c.14201G>A	{"RYR1": {"c.7361G>A": 1, "c.14201G>A": 1}}	\N
7941582	7941119	c.6617C>T/c.12028G>A	{"RYR1": {"c.6617C>T": 1, "c.12028G>A": 1}}	\N
7941583	7941119	c.7291G>T/c.7760A>G	{"RYR1": {"c.7291G>T": 1, "c.7760A>G": 1}}	\N
7941584	7941119	c.1201C>G/c.5183C>T	{"RYR1": {"c.1201C>G": 1, "c.5183C>T": 1}}	\N
7941585	7941119	c.103T>C/c.6635T>A	{"RYR1": {"c.103T>C": 1, "c.6635T>A": 1}}	\N
7941586	7941119	c.6302T>A/c.11708G>A	{"RYR1": {"c.6302T>A": 1, "c.11708G>A": 1}}	\N
7941587	7941119	c.7084G>A/c.9676G>C	{"RYR1": {"c.7084G>A": 1, "c.9676G>C": 1}}	\N
7941588	7941119	c.992_994dup/c.1201C>T	{"RYR1": {"c.1201C>T": 1, "c.992_994dup": 1}}	\N
7941589	7941119	c.11969G>T/c.14639T>C	{"RYR1": {"c.11969G>T": 1, "c.14639T>C": 1}}	\N
7941590	7941119	c.12413T>C/c.14210G>A	{"RYR1": {"c.12413T>C": 1, "c.14210G>A": 1}}	\N
7941591	7941119	c.7075C>T/c.7300G>A	{"RYR1": {"c.7075C>T": 1, "c.7300G>A": 1}}	\N
7941592	7941119	c.7360C>T/c.13673G>A	{"RYR1": {"c.7360C>T": 1, "c.13673G>A": 1}}	\N
7941593	7941119	c.12700G>T/c.14186A>C	{"RYR1": {"c.12700G>T": 1, "c.14186A>C": 1}}	\N
7941594	7941119	c.12700G>C/c.14558C>T	{"RYR1": {"c.12700G>C": 1, "c.14558C>T": 1}}	\N
7941595	7941119	c.7304G>A/c.14567C>G	{"RYR1": {"c.7304G>A": 1, "c.14567C>G": 1}}	\N
7941596	7941119	c.1021G>A/c.8518C>T	{"RYR1": {"c.1021G>A": 1, "c.8518C>T": 1}}	\N
7941597	7941119	c.12115A>T/c.14627A>G	{"RYR1": {"c.12115A>T": 1, "c.14627A>G": 1}}	\N
7941598	7941119	c.1615T>C/c.6304G>C	{"RYR1": {"c.1615T>C": 1, "c.6304G>C": 1}}	\N
7941599	7941119	c.1841G>T/c.12533G>T	{"RYR1": {"c.1841G>T": 1, "c.12533G>T": 1}}	\N
7941600	7941119	c.982C>T/c.14693T>C	{"RYR1": {"c.982C>T": 1, "c.14693T>C": 1}}	\N
7941601	7941119	c.1475G>A/c.6617C>G	{"RYR1": {"c.1475G>A": 1, "c.6617C>G": 1}}	\N
7941602	7941119	c.1597C>T/c.7199A>G	{"RYR1": {"c.1597C>T": 1, "c.7199A>G": 1}}	\N
7941603	7941119	c.1411C>T/c.14918C>T	{"RYR1": {"c.1411C>T": 1, "c.14918C>T": 1}}	\N
7941604	7941119	c.1202G>T/c.13702C>G	{"RYR1": {"c.1202G>T": 1, "c.13702C>G": 1}}	\N
7941605	7941119	c.6628G>T/c.9356G>A	{"RYR1": {"c.6628G>T": 1, "c.9356G>A": 1}}	\N
7941606	7941119	c.3166G>A/c.7372C>T	{"RYR1": {"c.3166G>A": 1, "c.7372C>T": 1}}	\N
7941607	7941119	c.6304G>C/c.14512C>G	{"RYR1": {"c.6304G>C": 1, "c.14512C>G": 1}}	\N
7941608	7941119	c.7123G>A/c.13505A>G	{"RYR1": {"c.7123G>A": 1, "c.13505A>G": 1}}	\N
7941609	7941119	c.12848A>T/c.14545G>A	{"RYR1": {"c.12848A>T": 1, "c.14545G>A": 1}}	\N
7941610	7941119	c.467G>A/c.488G>T	{"RYR1": {"c.467G>A": 1, "c.488G>T": 1}}	\N
7941611	7941119	c.487C>T/c.14051T>C	{"RYR1": {"c.487C>T": 1, "c.14051T>C": 1}}	\N
7941612	7941119	c.11126C>T/c.14918C>T	{"RYR1": {"c.11126C>T": 1, "c.14918C>T": 1}}	\N
7941613	7941119	c.38T>G/c.7199A>G	{"RYR1": {"c.38T>G": 1, "c.7199A>G": 1}}	\N
7941614	7941119	c.7304G>T/c.11086G>C	{"RYR1": {"c.7304G>T": 1, "c.11086G>C": 1}}	\N
7941615	7941119	c.8026C>T/c.14879T>A	{"RYR1": {"c.8026C>T": 1, "c.14879T>A": 1}}	\N
7941616	7941119	c.488G>T/c.3527C>T	{"RYR1": {"c.488G>T": 1, "c.3527C>T": 1}}	\N
7941617	7941119	c.7048G>A/c.14449A>T	{"RYR1": {"c.7048G>A": 1, "c.14449A>T": 1}}	\N
7941618	7941119	c.487C>T/c.11416G>A	{"RYR1": {"c.487C>T": 1, "c.11416G>A": 1}}	\N
7941619	7941119	c.10891G>T/c.14803G>A	{"RYR1": {"c.10891G>T": 1, "c.14803G>A": 1}}	\N
7941620	7941119	c.5440A>G/c.7076G>A	{"RYR1": {"c.5440A>G": 1, "c.7076G>A": 1}}	\N
7941621	7941119	c.7307G>A/c.11969G>T	{"RYR1": {"c.7307G>A": 1, "c.11969G>T": 1}}	\N
7941622	7941119	c.680A>T/c.14803G>A	{"RYR1": {"c.680A>T": 1, "c.14803G>A": 1}}	\N
7941623	7941119	c.1201C>T/c.14051T>C	{"RYR1": {"c.1201C>T": 1, "c.14051T>C": 1}}	\N
7941624	7941119	c.7036G>A/c.14680G>A	{"RYR1": {"c.7036G>A": 1, "c.14680G>A": 1}}	\N
7941625	7941119	c.8189A>G/c.14209C>T	{"RYR1": {"c.8189A>G": 1, "c.14209C>T": 1}}	\N
7941626	7941119	c.7360C>T/c.8600T>A	{"RYR1": {"c.7360C>T": 1, "c.8600T>A": 1}}	\N
7941627	7941119	c.7090T>G/c.14813T>C	{"RYR1": {"c.7090T>G": 1, "c.14813T>C": 1}}	\N
7941628	7941119	c.7089C>G/c.7304G>T	{"RYR1": {"c.7089C>G": 1, "c.7304G>T": 1}}	\N
7941629	7941119	c.38T>G/c.14782A>G	{"RYR1": {"c.38T>G": 1, "c.14782A>G": 1}}	\N
7941630	7941119	c.251C>T/c.7879G>C	{"RYR1": {"c.251C>T": 1, "c.7879G>C": 1}}	\N
7941631	7941119	c.9310G>A/c.13505A>G	{"RYR1": {"c.9310G>A": 1, "c.13505A>G": 1}}	\N
7941632	7941119	c.7522C>T/c.14201G>A	{"RYR1": {"c.7522C>T": 1, "c.14201G>A": 1}}	\N
7941633	7941119	c.5033A>G/c.11315G>A	{"RYR1": {"c.5033A>G": 1, "c.11315G>A": 1}}	\N
7941634	7941119	c.7304G>A/c.8729C>T	{"RYR1": {"c.7304G>A": 1, "c.8729C>T": 1}}	\N
7941635	7941119	c.1597C>T/c.14693T>C	{"RYR1": {"c.1597C>T": 1, "c.14693T>C": 1}}	\N
7941636	7941119	c.7043A>G/c.7778G>A	{"RYR1": {"c.7043A>G": 1, "c.7778G>A": 1}}	\N
7941637	7941119	c.529C>T/c.6847A>C	{"RYR1": {"c.529C>T": 1, "c.6847A>C": 1}}	\N
7941638	7941119	c.7089C>G/c.7304G>A	{"RYR1": {"c.7089C>G": 1, "c.7304G>A": 1}}	\N
7941639	7941119	c.1840C>T/c.5890C>T	{"RYR1": {"c.1840C>T": 1, "c.5890C>T": 1}}	\N
7941640	7941119	c.7063C>T/c.14270G>A	{"RYR1": {"c.7063C>T": 1, "c.14270G>A": 1}}	\N
7941641	7941119	c.6487C>T/c.10237A>T	{"RYR1": {"c.6487C>T": 1, "c.10237A>T": 1}}	\N
7941642	7941119	c.5186T>G/c.7123G>A	{"RYR1": {"c.5186T>G": 1, "c.7123G>A": 1}}	\N
7941643	7941119	c.14201G>A/c.14209C>T	{"RYR1": {"c.14201G>A": 1, "c.14209C>T": 1}}	\N
7941644	7941119	c.6488G>T/c.13990T>C	{"RYR1": {"c.6488G>T": 1, "c.13990T>C": 1}}	\N
7941645	7941119	c.1202G>T/c.9850T>A	{"RYR1": {"c.1202G>T": 1, "c.9850T>A": 1}}	\N
7941646	7941119	c.11132C>T/c.14210G>A	{"RYR1": {"c.11132C>T": 1, "c.14210G>A": 1}}	\N
7941647	7941119	c.1840C>T/c.8926C>T	{"RYR1": {"c.1840C>T": 1, "c.8926C>T": 1}}	\N
7941648	7941119	c.6388G>A/c.7042_7044delGAG	{"RYR1": {"c.6388G>A": 1, "c.7042_7044delGAG": 1}}	\N
7941649	7941119	c.11969G>T/c.15060G>C	{"RYR1": {"c.11969G>T": 1, "c.15060G>C": 1}}	\N
7941650	7941119	c.1202G>A/c.7018T>C	{"RYR1": {"c.1202G>A": 1, "c.7018T>C": 1}}	\N
7941651	7941119	c.680A>T/c.6628G>T	{"RYR1": {"c.680A>T": 1, "c.6628G>T": 1}}	\N
7941652	7941119	c.7032G>C/c.7304G>A	{"RYR1": {"c.7032G>C": 1, "c.7304G>A": 1}}	\N
7941653	7941119	c.1453A>G/c.7282G>A	{"RYR1": {"c.1453A>G": 1, "c.7282G>A": 1}}	\N
7941654	7941119	c.7007G>A/c.9850T>A	{"RYR1": {"c.7007G>A": 1, "c.9850T>A": 1}}	\N
7941655	7941119	c.1553T>C/c.9310G>A	{"RYR1": {"c.1553T>C": 1, "c.9310G>A": 1}}	\N
7941656	7941119	c.488G>T/c.9850T>A	{"RYR1": {"c.488G>T": 1, "c.9850T>A": 1}}	\N
7941657	7941119	c.152C>A/c.529C>T	{"RYR1": {"c.152C>A": 1, "c.529C>T": 1}}	\N
7941658	7941119	c.11708G>A/c.11723A>T	{"RYR1": {"c.11708G>A": 1, "c.11723A>T": 1}}	\N
7941659	7941119	c.487C>T/c.13994_13995delTCinsCT	{"RYR1": {"c.487C>T": 1, "c.13994_13995delTCinsCT": 1}}	\N
7941660	7941119	c.7036G>A/c.7385C>T	{"RYR1": {"c.7036G>A": 1, "c.7385C>T": 1}}	\N
7941661	7941119	c.4400A>G/c.7035C>A	{"RYR1": {"c.4400A>G": 1, "c.7035C>A": 1}}	\N
7941662	7941119	c.1201C>T/c.11416G>A	{"RYR1": {"c.1201C>T": 1, "c.11416G>A": 1}}	\N
7941663	7941119	c.12149C>A/c.12689T>G	{"RYR1": {"c.12149C>A": 1, "c.12689T>G": 1}}	\N
7941664	7941119	c.1615T>G/c.6304G>C	{"RYR1": {"c.1615T>G": 1, "c.6304G>C": 1}}	\N
7941665	7941119	c.6502G>A/c.10229C>A	{"RYR1": {"c.6502G>A": 1, "c.10229C>A": 1}}	\N
7941666	7941119	c.7060G>A/c.11314C>T	{"RYR1": {"c.7060G>A": 1, "c.11314C>T": 1}}	\N
7941667	7941119	c.6488G>T/c.9152G>A	{"RYR1": {"c.6488G>T": 1, "c.9152G>A": 1}}	\N
7941668	7941119	c.12689T>G/c.14627A>G	{"RYR1": {"c.12689T>G": 1, "c.14627A>G": 1}}	\N
7941669	7941119	c.1654C>T/c.9356G>A	{"RYR1": {"c.1654C>T": 1, "c.9356G>A": 1}}	\N
7941670	7941119	c.1834G>C/c.6502G>A	{"RYR1": {"c.1834G>C": 1, "c.6502G>A": 1}}	\N
7941671	7941119	c.6349G>C/c.14581C>T	{"RYR1": {"c.6349G>C": 1, "c.14581C>T": 1}}	\N
7941672	7941119	c.7304G>A/c.8189A>G	{"RYR1": {"c.7304G>A": 1, "c.8189A>G": 1}}	\N
7941673	7941119	c.131G>A/c.5183C>T	{"RYR1": {"c.131G>A": 1, "c.5183C>T": 1}}	\N
7941674	7941119	c.463C>A/c.14879T>A	{"RYR1": {"c.463C>A": 1, "c.14879T>A": 1}}	\N
7941675	7941119	c.6617C>T/c.14680G>A	{"RYR1": {"c.6617C>T": 1, "c.14680G>A": 1}}	\N
7941676	7941119	c.12689T>G/c.14497C>T	{"RYR1": {"c.12689T>G": 1, "c.14497C>T": 1}}	\N
7941677	7941119	c.6838G>A/c.14968A>G	{"RYR1": {"c.6838G>A": 1, "c.14968A>G": 1}}	\N
7941678	7941119	c.11969G>T/c.15059G>C	{"RYR1": {"c.11969G>T": 1, "c.15059G>C": 1}}	\N
7941679	7941119	c.6628G>T/c.8600T>A	{"RYR1": {"c.6628G>T": 1, "c.8600T>A": 1}}	\N
7941680	7941119	c.7373G>A/c.7760A>G	{"RYR1": {"c.7373G>A": 1, "c.7760A>G": 1}}	\N
7941681	7941119	c.1202G>A/c.7097C>G	{"RYR1": {"c.1202G>A": 1, "c.7097C>G": 1}}	\N
7941682	7941119	c.190T>C/c.7291G>T	{"RYR1": {"c.190T>C": 1, "c.7291G>T": 1}}	\N
7941683	7941119	c.533A>G/c.8654C>G	{"RYR1": {"c.533A>G": 1, "c.8654C>G": 1}}	\N
7941684	7941119	c.7360C>T/c.9356G>A	{"RYR1": {"c.7360C>T": 1, "c.9356G>A": 1}}	\N
7941685	7941119	c.487C>T/c.6377G>A	{"RYR1": {"c.487C>T": 1, "c.6377G>A": 1}}	\N
7941686	7941119	c.1459C>G/c.7063C>T	{"RYR1": {"c.1459C>G": 1, "c.7063C>T": 1}}	\N
7941687	7941119	c.1201C>A/c.5183C>T	{"RYR1": {"c.1201C>A": 1, "c.5183C>T": 1}}	\N
7941688	7941119	c.38T>G/c.7777C>G	{"RYR1": {"c.38T>G": 1, "c.7777C>G": 1}}	\N
7941689	7941119	c.496G>A/c.7523G>A	{"RYR1": {"c.496G>A": 1, "c.7523G>A": 1}}	\N
7941690	7941119	c.103T>C/c.13990T>C	{"RYR1": {"c.103T>C": 1, "c.13990T>C": 1}}	\N
7941691	7941119	c.1202G>A/c.7879G>A	{"RYR1": {"c.1202G>A": 1, "c.7879G>A": 1}}	\N
7941692	7941119	c.5183C>T/c.14825G>T	{"RYR1": {"c.5183C>T": 1, "c.14825G>T": 1}}	\N
7941693	7941119	c.487C>T/c.1422G>T	{"RYR1": {"c.487C>T": 1, "c.1422G>T": 1}}	\N
7941694	7941119	c.178G>T/c.7304G>T	{"RYR1": {"c.178G>T": 1, "c.7304G>T": 1}}	\N
7941695	7941119	c.103T>C/c.641C>T	{"RYR1": {"c.103T>C": 1, "c.641C>T": 1}}	\N
7941696	7941119	c.10043G>A/c.12700G>T	{"RYR1": {"c.10043G>A": 1, "c.12700G>T": 1}}	\N
7941697	7941119	c.7372C>T/c.7528T>C	{"RYR1": {"c.7372C>T": 1, "c.7528T>C": 1}}	\N
7941698	7941119	c.7304G>T/c.10252A>G	{"RYR1": {"c.7304G>T": 1, "c.10252A>G": 1}}	\N
7941699	7941119	c.742G>A/c.8188G>C	{"RYR1": {"c.742G>A": 1, "c.8188G>C": 1}}	\N
7941700	7941119	c.14477C>T/c.15060G>C	{"RYR1": {"c.14477C>T": 1, "c.15060G>C": 1}}	\N
7941701	7941119	c.7310C>T/c.10750G>C	{"RYR1": {"c.7310C>T": 1, "c.10750G>C": 1}}	\N
7941702	7941119	c.97A>G/c.14879T>A	{"RYR1": {"c.97A>G": 1, "c.14879T>A": 1}}	\N
7941703	7941119	c.7282G>A/c.11132C>T	{"RYR1": {"c.7282G>A": 1, "c.11132C>T": 1}}	\N
7941704	7941119	c.641C>T/c.9310G>A	{"RYR1": {"c.641C>T": 1, "c.9310G>A": 1}}	\N
7941705	7941119	c.178G>T/c.7304G>A	{"RYR1": {"c.178G>T": 1, "c.7304G>A": 1}}	\N
7941706	7941119	c.8198G>A/c.14918C>T	{"RYR1": {"c.8198G>A": 1, "c.14918C>T": 1}}	\N
7941707	7941119	c.51_53del/c.7310C>T	{"RYR1": {"c.7310C>T": 1, "c.51_53del": 1}}	\N
7941708	7941119	c.1202G>A/c.7085A>G	{"RYR1": {"c.1202G>A": 1, "c.7085A>G": 1}}	\N
7941709	7941119	c.12242C>T/c.14512C>G	{"RYR1": {"c.12242C>T": 1, "c.14512C>G": 1}}	\N
7941710	7941119	c.9652G>A/c.14210G>A	{"RYR1": {"c.9652G>A": 1, "c.14210G>A": 1}}	\N
7941711	7941119	c.7300G>A/c.14558C>T	{"RYR1": {"c.7300G>A": 1, "c.14558C>T": 1}}	\N
7941712	7941119	c.1589G>A/c.11723A>T	{"RYR1": {"c.1589G>A": 1, "c.11723A>T": 1}}	\N
7941713	7941119	c.12532G>A/c.14539G>C	{"RYR1": {"c.12532G>A": 1, "c.14539G>C": 1}}	\N
7941714	7941119	c.5033A>G/c.7048G>A	{"RYR1": {"c.5033A>G": 1, "c.7048G>A": 1}}	\N
7941715	7941119	c.6502G>A/c.12028G>A	{"RYR1": {"c.6502G>A": 1, "c.12028G>A": 1}}	\N
7941716	7941119	c.11315G>A/c.12533G>T	{"RYR1": {"c.11315G>A": 1, "c.12533G>T": 1}}	\N
7941717	7941119	c.5186T>G/c.7076G>A	{"RYR1": {"c.5186T>G": 1, "c.7076G>A": 1}}	\N
7941718	7941119	c.2996G>A/c.12700G>C	{"RYR1": {"c.2996G>A": 1, "c.12700G>C": 1}}	\N
7941719	7941119	c.2996G>A/c.12700G>T	{"RYR1": {"c.2996G>A": 1, "c.12700G>T": 1}}	\N
7941720	7941119	c.533A>G/c.9152G>A	{"RYR1": {"c.533A>G": 1, "c.9152G>A": 1}}	\N
7941721	7941119	c.6349G>C/c.11518G>A	{"RYR1": {"c.6349G>C": 1, "c.11518G>A": 1}}	\N
7941722	7941119	c.652G>A/c.6349G>C	{"RYR1": {"c.652G>A": 1, "c.6349G>C": 1}}	\N
7941723	7941119	c.4747C>T/c.7360C>T	{"RYR1": {"c.4747C>T": 1, "c.7360C>T": 1}}	\N
7941724	7941119	c.1597C>T/c.3667G>A	{"RYR1": {"c.1597C>T": 1, "c.3667G>A": 1}}	\N
7941725	7941119	c.1615T>G/c.7317G>C	{"RYR1": {"c.1615T>G": 1, "c.7317G>C": 1}}	\N
7941726	7941119	c.14477C>T/c.15059G>C	{"RYR1": {"c.14477C>T": 1, "c.15059G>C": 1}}	\N
7941727	7941119	c.652G>A/c.14918C>T	{"RYR1": {"c.652G>A": 1, "c.14918C>T": 1}}	\N
7941728	7941119	c.497A>G/c.8026C>T	{"RYR1": {"c.497A>G": 1, "c.8026C>T": 1}}	\N
7941729	7941119	c.10043G>A/c.12700G>C	{"RYR1": {"c.10043G>A": 1, "c.12700G>C": 1}}	\N
7941730	7941119	c.14422_14423delinsAA/c.14497C>T	{"RYR1": {"c.14497C>T": 1, "c.14422_14423delinsAA": 1}}	\N
7941731	7941119	c.7007G>A/c.8518C>T	{"RYR1": {"c.7007G>A": 1, "c.8518C>T": 1}}	\N
7941732	7941119	c.6037A>C/c.7076G>A	{"RYR1": {"c.6037A>C": 1, "c.7076G>A": 1}}	\N
7941733	7941119	c.1201C>T/c.14639T>C	{"RYR1": {"c.1201C>T": 1, "c.14639T>C": 1}}	\N
7941734	7941119	c.6487C>T/c.14817C>A	{"RYR1": {"c.6487C>T": 1, "c.14817C>A": 1}}	\N
7941735	7941119	c.7043A>G/c.14782A>G	{"RYR1": {"c.7043A>G": 1, "c.14782A>G": 1}}	\N
7941736	7941119	c.12064A>G/c.14209C>T	{"RYR1": {"c.12064A>G": 1, "c.14209C>T": 1}}	\N
7941737	7941119	c.7360C>T/c.14197T>G	{"RYR1": {"c.7360C>T": 1, "c.14197T>G": 1}}	\N
7941738	7941119	c.493G>A/c.12700G>C	{"RYR1": {"c.493G>A": 1, "c.12700G>C": 1}}	\N
7941739	7941119	c.1598G>A/c.7354C>T	{"RYR1": {"c.1598G>A": 1, "c.7354C>T": 1}}	\N
7941740	7941119	c.13702C>G/c.14803G>A	{"RYR1": {"c.13702C>G": 1, "c.14803G>A": 1}}	\N
7941741	7941119	c.1615T>G/c.4747C>T	{"RYR1": {"c.1615T>G": 1, "c.4747C>T": 1}}	\N
7941742	7941119	c.479A>G/c.1589G>A	{"RYR1": {"c.479A>G": 1, "c.1589G>A": 1}}	\N
7941743	7941119	c.533A>C/c.14539G>C	{"RYR1": {"c.533A>C": 1, "c.14539G>C": 1}}	\N
7941744	7941119	c.1615T>C/c.8198G>A	{"RYR1": {"c.1615T>C": 1, "c.8198G>A": 1}}	\N
7941745	7941119	c.7282G>A/c.10252A>G	{"RYR1": {"c.7282G>A": 1, "c.10252A>G": 1}}	\N
7941746	7941119	c.641C>T/c.6487C>T	{"RYR1": {"c.641C>T": 1, "c.6487C>T": 1}}	\N
7941747	7941119	c.6710G>A/c.14539G>C	{"RYR1": {"c.6710G>A": 1, "c.14539G>C": 1}}	\N
7941748	7941119	c.2996G>A/c.7084G>A	{"RYR1": {"c.2996G>A": 1, "c.7084G>A": 1}}	\N
7941749	7941119	c.463C>A/c.5132A>G	{"RYR1": {"c.463C>A": 1, "c.5132A>G": 1}}	\N
7941750	7941119	c.7304G>T/c.11132C>T	{"RYR1": {"c.7304G>T": 1, "c.11132C>T": 1}}	\N
7941751	7941119	c.533A>G/c.14364+1G>T	{"RYR1": {"c.533A>G": 1, "c.14364+1G>T": 1}}	\N
7941752	7941119	c.2996G>A/c.6502G>A	{"RYR1": {"c.2996G>A": 1, "c.6502G>A": 1}}	\N
7941753	7941119	c.7523G>A/c.14509C>G	{"RYR1": {"c.7523G>A": 1, "c.14509C>G": 1}}	\N
7941754	7941119	c.742G>C/c.8188G>C	{"RYR1": {"c.742G>C": 1, "c.8188G>C": 1}}	\N
7941755	7941119	c.1201C>G/c.7063C>T	{"RYR1": {"c.1201C>G": 1, "c.7063C>T": 1}}	\N
7941756	7941119	c.7090T>G/c.14567C>G	{"RYR1": {"c.7090T>G": 1, "c.14567C>G": 1}}	\N
7941757	7941119	c.7291G>A/c.14471T>C	{"RYR1": {"c.7291G>A": 1, "c.14471T>C": 1}}	\N
7941758	7941119	c.190T>C/c.1021G>C	{"RYR1": {"c.190T>C": 1, "c.1021G>C": 1}}	\N
7941759	7941119	c.190T>C/c.7035C>A	{"RYR1": {"c.190T>C": 1, "c.7035C>A": 1}}	\N
7941760	7941119	c.7304G>A/c.12121C>T	{"RYR1": {"c.7304G>A": 1, "c.12121C>T": 1}}	\N
7941761	7941119	c.11314C>T/c.12149C>A	{"RYR1": {"c.11314C>T": 1, "c.12149C>A": 1}}	\N
7941762	7941119	c.190T>C/c.1021G>A	{"RYR1": {"c.190T>C": 1, "c.1021G>A": 1}}	\N
7941763	7941119	c.7007G>A/c.14524G>A	{"RYR1": {"c.7007G>A": 1, "c.14524G>A": 1}}	\N
7941764	7941119	c.7084G>A/c.9868G>A	{"RYR1": {"c.7084G>A": 1, "c.9868G>A": 1}}	\N
7941765	7941119	c.8005G>A/c.14803G>A	{"RYR1": {"c.8005G>A": 1, "c.14803G>A": 1}}	\N
7941766	7941119	c.1615T>C/c.14814C>G	{"RYR1": {"c.1615T>C": 1, "c.14814C>G": 1}}	\N
7941767	7941119	c.742G>C/c.12383C>T	{"RYR1": {"c.742G>C": 1, "c.12383C>T": 1}}	\N
7941768	7941119	c.6487C>T/c.14782A>G	{"RYR1": {"c.6487C>T": 1, "c.14782A>G": 1}}	\N
7941769	7941119	c.51_53del/c.6502G>A	{"RYR1": {"c.6502G>A": 1, "c.51_53del": 1}}	\N
7941770	7941119	c.6628G>T/c.7787C>T	{"RYR1": {"c.6628G>T": 1, "c.7787C>T": 1}}	\N
7941771	7941119	c.7123G>A/c.12532G>A	{"RYR1": {"c.7123G>A": 1, "c.12532G>A": 1}}	\N
7941772	7941119	c.1565A>C/c.3172G>A	{"RYR1": {"c.1565A>C": 1, "c.3172G>A": 1}}	\N
7941773	7941119	c.479A>G/c.1840C>T	{"RYR1": {"c.479A>G": 1, "c.1840C>T": 1}}	\N
7941774	7941119	c.6488G>A/c.7112A>G	{"RYR1": {"c.6488G>A": 1, "c.7112A>G": 1}}	\N
7941775	7941119	c.7282G>A/c.8729C>T	{"RYR1": {"c.7282G>A": 1, "c.8729C>T": 1}}	\N
7941776	7941119	c.463C>A/c.14201G>A	{"RYR1": {"c.463C>A": 1, "c.14201G>A": 1}}	\N
7941777	7941119	c.1411C>T/c.7291G>T	{"RYR1": {"c.1411C>T": 1, "c.7291G>T": 1}}	\N
7941778	7941119	c.6612C>G/c.7879G>A	{"RYR1": {"c.6612C>G": 1, "c.7879G>A": 1}}	\N
7941779	7941119	c.14497C>T/c.14813T>C	{"RYR1": {"c.14497C>T": 1, "c.14813T>C": 1}}	\N
7941780	7941119	c.7291G>A/c.7760A>G	{"RYR1": {"c.7291G>A": 1, "c.7760A>G": 1}}	\N
7941781	7941119	c.6502G>A/c.8290G>A	{"RYR1": {"c.6502G>A": 1, "c.8290G>A": 1}}	\N
7941782	7941119	c.7084G>A/c.14449A>T	{"RYR1": {"c.7084G>A": 1, "c.14449A>T": 1}}	\N
7941783	7941119	c.5440A>G/c.7124G>C	{"RYR1": {"c.5440A>G": 1, "c.7124G>C": 1}}	\N
7941784	7941119	c.11315G>A/c.14270G>A	{"RYR1": {"c.11315G>A": 1, "c.14270G>A": 1}}	\N
7941785	7941119	c.455C>A/c.7372C>T	{"RYR1": {"c.455C>A": 1, "c.7372C>T": 1}}	\N
7941786	7941119	c.7360C>T/c.7787C>T	{"RYR1": {"c.7360C>T": 1, "c.7787C>T": 1}}	\N
7941787	7941119	c.7123G>A/c.10252A>G	{"RYR1": {"c.7123G>A": 1, "c.10252A>G": 1}}	\N
7941788	7941119	c.1589G>A/c.2996G>A	{"RYR1": {"c.1589G>A": 1, "c.2996G>A": 1}}	\N
7941789	7941119	c.1411C>T/c.7291G>A	{"RYR1": {"c.1411C>T": 1, "c.7291G>A": 1}}	\N
7941790	7941119	c.7355G>C/c.14803G>A	{"RYR1": {"c.7355G>C": 1, "c.14803G>A": 1}}	\N
7941791	7941119	c.529C>T/c.1834G>C	{"RYR1": {"c.529C>T": 1, "c.1834G>C": 1}}	\N
7941792	7941119	c.497A>G/c.1840C>T	{"RYR1": {"c.497A>G": 1, "c.1840C>T": 1}}	\N
7941793	7941119	c.7036G>A/c.12028G>A	{"RYR1": {"c.7036G>A": 1, "c.12028G>A": 1}}	\N
7941794	7941119	c.6387C>G/c.7032G>C	{"RYR1": {"c.6387C>G": 1, "c.7032G>C": 1}}	\N
7941795	7941119	c.1840C>T/c.14186A>C	{"RYR1": {"c.1840C>T": 1, "c.14186A>C": 1}}	\N
7941796	7941119	c.742G>A/c.12383C>T	{"RYR1": {"c.742G>A": 1, "c.12383C>T": 1}}	\N
7941797	7941119	c.12553G>A/c.12700G>C	{"RYR1": {"c.12553G>A": 1, "c.12700G>C": 1}}	\N
7941798	7941119	c.3166G>C/c.5033A>G	{"RYR1": {"c.3166G>C": 1, "c.5033A>G": 1}}	\N
7941799	7941119	c.677T>A/c.1840C>T	{"RYR1": {"c.677T>A": 1, "c.1840C>T": 1}}	\N
7941800	7941119	c.742G>A/c.7522C>G	{"RYR1": {"c.742G>A": 1, "c.7522C>G": 1}}	\N
7941801	7941119	c.178G>A/c.14477C>T	{"RYR1": {"c.178G>A": 1, "c.14477C>T": 1}}	\N
7941802	7941119	c.7300G>A/c.10750G>C	{"RYR1": {"c.7300G>A": 1, "c.10750G>C": 1}}	\N
7941803	7941119	c.493G>A/c.12700G>T	{"RYR1": {"c.493G>A": 1, "c.12700G>T": 1}}	\N
7941804	7941119	c.7084G>A/c.7879G>A	{"RYR1": {"c.7084G>A": 1, "c.7879G>A": 1}}	\N
7941805	7941119	c.7018T>C/c.12700G>T	{"RYR1": {"c.7018T>C": 1, "c.12700G>T": 1}}	\N
7941806	7941119	c.1597C>T/c.7777C>G	{"RYR1": {"c.1597C>T": 1, "c.7777C>G": 1}}	\N
7941807	7941119	c.6488G>T/c.8054C>T	{"RYR1": {"c.6488G>T": 1, "c.8054C>T": 1}}	\N
7941808	7941119	c.7360C>T/c.9499C>T	{"RYR1": {"c.7360C>T": 1, "c.9499C>T": 1}}	\N
7941809	7941119	c.2996G>A/c.7060G>A	{"RYR1": {"c.2996G>A": 1, "c.7060G>A": 1}}	\N
7941810	7941119	c.7042_7044delGAG/c.10750G>C	{"RYR1": {"c.10750G>C": 1, "c.7042_7044delGAG": 1}}	\N
7941811	7941119	c.7310C>T/c.13702C>G	{"RYR1": {"c.7310C>T": 1, "c.13702C>G": 1}}	\N
7941812	7941119	c.103T>C/c.9848G>A	{"RYR1": {"c.103T>C": 1, "c.9848G>A": 1}}	\N
7941813	7941119	c.1202G>A/c.14126C>T	{"RYR1": {"c.1202G>A": 1, "c.14126C>T": 1}}	\N
7941814	7941119	c.1459C>G/c.1589G>A	{"RYR1": {"c.1459C>G": 1, "c.1589G>A": 1}}	\N
7941815	7941119	c.1654C>T/c.7355G>A	{"RYR1": {"c.1654C>T": 1, "c.7355G>A": 1}}	\N
7941816	7941119	c.38T>G/c.14693T>C	{"RYR1": {"c.38T>G": 1, "c.14693T>C": 1}}	\N
7941817	7941119	c.7042_7044delGAG/c.12028G>A	{"RYR1": {"c.12028G>A": 1, "c.7042_7044delGAG": 1}}	\N
7941818	7941119	c.1453A>G/c.7304G>T	{"RYR1": {"c.1453A>G": 1, "c.7304G>T": 1}}	\N
7941819	7941119	c.1654C>T/c.7355G>C	{"RYR1": {"c.1654C>T": 1, "c.7355G>C": 1}}	\N
7941820	7941119	c.3172G>A/c.7373G>A	{"RYR1": {"c.3172G>A": 1, "c.7373G>A": 1}}	\N
7941821	7941119	c.7018T>C/c.12700G>C	{"RYR1": {"c.7018T>C": 1, "c.12700G>C": 1}}	\N
7941822	7941119	c.6488G>C/c.7112A>G	{"RYR1": {"c.6488G>C": 1, "c.7112A>G": 1}}	\N
7941823	7941119	c.5033A>G/c.7036G>A	{"RYR1": {"c.5033A>G": 1, "c.7036G>A": 1}}	\N
7941824	7941119	c.1615T>C/c.4747C>T	{"RYR1": {"c.1615T>C": 1, "c.4747C>T": 1}}	\N
7941825	7941119	c.12553G>A/c.12700G>T	{"RYR1": {"c.12553G>A": 1, "c.12700G>T": 1}}	\N
7941826	7941119	c.1615T>G/c.3172G>A	{"RYR1": {"c.1615T>G": 1, "c.3172G>A": 1}}	\N
7941827	7941119	c.2924G>A/c.7043A>G	{"RYR1": {"c.2924G>A": 1, "c.7043A>G": 1}}	\N
7941828	7941119	c.7355G>A/c.14803G>A	{"RYR1": {"c.7355G>A": 1, "c.14803G>A": 1}}	\N
7941829	7941119	c.5441T>A/c.7043A>G	{"RYR1": {"c.5441T>A": 1, "c.7043A>G": 1}}	\N
7941830	7941119	c.3172G>A/c.7373G>T	{"RYR1": {"c.3172G>A": 1, "c.7373G>T": 1}}	\N
7941831	7941119	c.1453A>G/c.7304G>A	{"RYR1": {"c.1453A>G": 1, "c.7304G>A": 1}}	\N
7941832	7941119	c.7523G>A/c.14558C>T	{"RYR1": {"c.7523G>A": 1, "c.14558C>T": 1}}	\N
7941833	7941119	c.1201C>A/c.7063C>T	{"RYR1": {"c.1201C>A": 1, "c.7063C>T": 1}}	\N
7941834	7941119	c.680A>T/c.7358T>C	{"RYR1": {"c.680A>T": 1, "c.7358T>C": 1}}	\N
7941835	7941119	c.130C>T/c.8054C>T	{"RYR1": {"c.130C>T": 1, "c.8054C>T": 1}}	\N
7941836	7941119	c.6628G>T/c.9499C>T	{"RYR1": {"c.6628G>T": 1, "c.9499C>T": 1}}	\N
7941837	7941119	c.6488G>T/c.8654C>G	{"RYR1": {"c.6488G>T": 1, "c.8654C>G": 1}}	\N
7941838	7941119	c.8026C>T/c.11126C>T	{"RYR1": {"c.8026C>T": 1, "c.11126C>T": 1}}	\N
7941839	7941119	c.4747C>T/c.7372C>T	{"RYR1": {"c.4747C>T": 1, "c.7372C>T": 1}}	\N
7941840	7941119	c.1202G>A/c.7771C>G	{"RYR1": {"c.1202G>A": 1, "c.7771C>G": 1}}	\N
7941841	7941119	c.6487C>T/c.7032G>C	{"RYR1": {"c.6487C>T": 1, "c.7032G>C": 1}}	\N
7941842	7941119	c.6488G>T/c.8527T>C	{"RYR1": {"c.6488G>T": 1, "c.8527T>C": 1}}	\N
7941843	7941119	c.119G>C/c.14539G>C	{"RYR1": {"c.119G>C": 1, "c.14539G>C": 1}}	\N
7941844	7941119	c.1459C>G/c.8026C>T	{"RYR1": {"c.1459C>G": 1, "c.8026C>T": 1}}	\N
7941845	7941119	c.742G>C/c.7522C>G	{"RYR1": {"c.742G>C": 1, "c.7522C>G": 1}}	\N
7941846	7941119	c.13918A>G/c.14803G>A	{"RYR1": {"c.13918A>G": 1, "c.14803G>A": 1}}	\N
7941847	7941119	c.1615T>G/c.8198G>A	{"RYR1": {"c.1615T>G": 1, "c.8198G>A": 1}}	\N
7941848	7941119	c.1654C>T/c.8054C>T	{"RYR1": {"c.1654C>T": 1, "c.8054C>T": 1}}	\N
7941849	7941119	c.7124G>C/c.14680G>A	{"RYR1": {"c.7124G>C": 1, "c.14680G>A": 1}}	\N
7941850	7941119	c.1202G>A/c.7771C>T	{"RYR1": {"c.1202G>A": 1, "c.7771C>T": 1}}	\N
7941851	7941119	c.1841G>T/c.12028G>A	{"RYR1": {"c.1841G>T": 1, "c.12028G>A": 1}}	\N
7941852	7941119	c.533A>G/c.3172G>A	{"RYR1": {"c.533A>G": 1, "c.3172G>A": 1}}	\N
7941853	7941119	c.7360C>T/c.13672C>T	{"RYR1": {"c.7360C>T": 1, "c.13672C>T": 1}}	\N
7941854	7941119	c.3166G>C/c.8290G>A	{"RYR1": {"c.3166G>C": 1, "c.8290G>A": 1}}	\N
7941855	7941119	c.7523G>A/c.11723A>T	{"RYR1": {"c.7523G>A": 1, "c.11723A>T": 1}}	\N
7941856	7941119	c.8654C>G/c.14512C>G	{"RYR1": {"c.8654C>G": 1, "c.14512C>G": 1}}	\N
7941857	7941119	c.3527C>T/c.7360C>T	{"RYR1": {"c.3527C>T": 1, "c.7360C>T": 1}}	\N
7941858	7941119	c.463C>A/c.10043G>A	{"RYR1": {"c.463C>A": 1, "c.10043G>A": 1}}	\N
7941859	7941119	c.3127C>T/c.6838G>A	{"RYR1": {"c.3127C>T": 1, "c.6838G>A": 1}}	\N
7941860	7941119	c.7300G>A/c.14509C>G	{"RYR1": {"c.7300G>A": 1, "c.14509C>G": 1}}	\N
7941861	7941119	c.2654G>A/c.6488G>T	{"RYR1": {"c.2654G>A": 1, "c.6488G>T": 1}}	\N
7941862	7941119	c.8026C>T/c.13934G>A	{"RYR1": {"c.8026C>T": 1, "c.13934G>A": 1}}	\N
7941863	7941119	c.7487C>T/c.12149C>A	{"RYR1": {"c.7487C>T": 1, "c.12149C>A": 1}}	\N
7941864	7941119	c.2654G>A/c.6488G>A	{"RYR1": {"c.2654G>A": 1, "c.6488G>A": 1}}	\N
7941865	7941119	c.6628G>T/c.13672C>T	{"RYR1": {"c.6628G>T": 1, "c.13672C>T": 1}}	\N
7941866	7941119	c.1565A>C/c.14197T>G	{"RYR1": {"c.1565A>C": 1, "c.14197T>G": 1}}	\N
7941867	7941119	c.487C>T/c.12355A>T	{"RYR1": {"c.487C>T": 1, "c.12355A>T": 1}}	\N
7941868	7941119	c.7084G>A/c.12064A>G	{"RYR1": {"c.7084G>A": 1, "c.12064A>G": 1}}	\N
7941869	7941119	c.533A>G/c.12115A>T	{"RYR1": {"c.533A>G": 1, "c.12115A>T": 1}}	\N
7941870	7941119	c.6488G>T/c.13673G>A	{"RYR1": {"c.6488G>T": 1, "c.13673G>A": 1}}	\N
7941871	7941119	c.103T>C/c.8054C>T	{"RYR1": {"c.103T>C": 1, "c.8054C>T": 1}}	\N
7941872	7941119	c.7354C>T/c.7522C>G	{"RYR1": {"c.7354C>T": 1, "c.7522C>G": 1}}	\N
7941873	7941119	c.14186A>C/c.14627A>G	{"RYR1": {"c.14186A>C": 1, "c.14627A>G": 1}}	\N
7941874	7941119	c.5033A>G/c.14627A>G	{"RYR1": {"c.5033A>G": 1, "c.14627A>G": 1}}	\N
7941875	7941119	c.2654G>A/c.6488G>C	{"RYR1": {"c.2654G>A": 1, "c.6488G>C": 1}}	\N
7941876	7941119	c.7360C>T/c.9649T>C	{"RYR1": {"c.7360C>T": 1, "c.9649T>C": 1}}	\N
7941877	7941119	c.1202G>T/c.6710G>A	{"RYR1": {"c.1202G>T": 1, "c.6710G>A": 1}}	\N
7941878	7941119	c.7084G>A/c.14509C>G	{"RYR1": {"c.7084G>A": 1, "c.14509C>G": 1}}	\N
7941879	7941119	c.9868G>A/c.14545G>A	{"RYR1": {"c.9868G>A": 1, "c.14545G>A": 1}}	\N
7941880	7941119	c.7372C>T/c.8054C>T	{"RYR1": {"c.7372C>T": 1, "c.8054C>T": 1}}	\N
7941881	7941119	c.6612C>G/c.10556C>T	{"RYR1": {"c.6612C>G": 1, "c.10556C>T": 1}}	\N
7941882	7941119	c.493G>A/c.7361G>A	{"RYR1": {"c.493G>A": 1, "c.7361G>A": 1}}	\N
7941883	7941119	c.6838G>A/c.13934G>A	{"RYR1": {"c.6838G>A": 1, "c.13934G>A": 1}}	\N
7941884	7941119	c.7076G>A/c.11086G>C	{"RYR1": {"c.7076G>A": 1, "c.11086G>C": 1}}	\N
7941885	7941119	c.1841G>T/c.8290G>A	{"RYR1": {"c.1841G>T": 1, "c.8290G>A": 1}}	\N
7941886	7941119	c.677T>A/c.7076G>A	{"RYR1": {"c.677T>A": 1, "c.7076G>A": 1}}	\N
7941887	7941119	c.7760A>G/c.12700G>C	{"RYR1": {"c.7760A>G": 1, "c.12700G>C": 1}}	\N
7941888	7941119	c.7042_7044delGAG/c.14558C>T	{"RYR1": {"c.14558C>T": 1, "c.7042_7044delGAG": 1}}	\N
7941889	7941119	c.6628G>T/c.9848G>A	{"RYR1": {"c.6628G>T": 1, "c.9848G>A": 1}}	\N
7941890	7941119	c.7354C>T/c.12383C>T	{"RYR1": {"c.7354C>T": 1, "c.12383C>T": 1}}	\N
7941891	7941119	c.488G>A/c.14209C>T	{"RYR1": {"c.488G>A": 1, "c.14209C>T": 1}}	\N
7941892	7941119	c.3172G>A/c.7361G>A	{"RYR1": {"c.3172G>A": 1, "c.7361G>A": 1}}	\N
7941893	7941119	c.1565A>C/c.4747C>T	{"RYR1": {"c.1565A>C": 1, "c.4747C>T": 1}}	\N
7941894	7941119	c.103T>C/c.9649T>C	{"RYR1": {"c.103T>C": 1, "c.9649T>C": 1}}	\N
7941895	7941119	c.493G>A/c.7090T>G	{"RYR1": {"c.493G>A": 1, "c.7090T>G": 1}}	\N
7941896	7941119	c.7007G>A/c.7018T>C	{"RYR1": {"c.7007G>A": 1, "c.7018T>C": 1}}	\N
7941897	7941119	c.6838G>A/c.7075C>T	{"RYR1": {"c.6838G>A": 1, "c.7075C>T": 1}}	\N
7941898	7941119	c.7300G>A/c.12064A>G	{"RYR1": {"c.7300G>A": 1, "c.12064A>G": 1}}	\N
7941899	7941119	c.455C>A/c.14627A>G	{"RYR1": {"c.455C>A": 1, "c.14627A>G": 1}}	\N
7941900	7941119	c.7304G>A/c.10891G>T	{"RYR1": {"c.7304G>A": 1, "c.10891G>T": 1}}	\N
7941901	7941119	c.7304G>T/c.8729C>T	{"RYR1": {"c.7304G>T": 1, "c.8729C>T": 1}}	\N
7941902	7941119	c.526G>A/c.742G>A	{"RYR1": {"c.526G>A": 1, "c.742G>A": 1}}	\N
7941903	7941119	c.103T>C/c.7089C>G	{"RYR1": {"c.103T>C": 1, "c.7089C>G": 1}}	\N
7941904	7941119	c.455C>A/c.3166G>C	{"RYR1": {"c.455C>A": 1, "c.3166G>C": 1}}	\N
7941905	7941119	c.526G>A/c.742G>C	{"RYR1": {"c.526G>A": 1, "c.742G>C": 1}}	\N
7941906	7941119	c.1654C>T/c.11958C>G	{"RYR1": {"c.1654C>T": 1, "c.11958C>G": 1}}	\N
7941907	7941119	c.6628G>T/c.14197T>G	{"RYR1": {"c.6628G>T": 1, "c.14197T>G": 1}}	\N
7941908	7941119	c.1841G>T/c.3095G>A	{"RYR1": {"c.1841G>T": 1, "c.3095G>A": 1}}	\N
7941909	7941119	c.7282G>A/c.11086G>C	{"RYR1": {"c.7282G>A": 1, "c.11086G>C": 1}}	\N
7941910	7941119	c.5183C>T/c.8518C>T	{"RYR1": {"c.5183C>T": 1, "c.8518C>T": 1}}	\N
7941911	7941119	c.7112A>G/c.7523G>A	{"RYR1": {"c.7112A>G": 1, "c.7523G>A": 1}}	\N
7941912	7941119	c.1615T>G/c.14051T>C	{"RYR1": {"c.1615T>G": 1, "c.14051T>C": 1}}	\N
7941913	7941119	c.38T>G/c.3667G>A	{"RYR1": {"c.38T>G": 1, "c.3667G>A": 1}}	\N
7941914	7941119	c.455C>A/c.7360C>T	{"RYR1": {"c.455C>A": 1, "c.7360C>T": 1}}	\N
7941915	7941119	c.12700G>T/c.14558C>T	{"RYR1": {"c.12700G>T": 1, "c.14558C>T": 1}}	\N
7941916	7941119	c.6387C>G/c.11748T>G	{"RYR1": {"c.6387C>G": 1, "c.11748T>G": 1}}	\N
7941917	7941119	c.7304G>T/c.14813T>C	{"RYR1": {"c.7304G>T": 1, "c.14813T>C": 1}}	\N
7941918	7941119	c.7063C>T/c.12532G>A	{"RYR1": {"c.7063C>T": 1, "c.12532G>A": 1}}	\N
7941919	7941119	c.742G>A/c.7210G>A	{"RYR1": {"c.742G>A": 1, "c.7210G>A": 1}}	\N
7941920	7941119	c.6617C>G/c.11723A>T	{"RYR1": {"c.6617C>G": 1, "c.11723A>T": 1}}	\N
7941921	7941119	c.6743G>A/c.14497C>T	{"RYR1": {"c.6743G>A": 1, "c.14497C>T": 1}}	\N
7941922	7941119	c.1615T>C/c.11416G>A	{"RYR1": {"c.1615T>C": 1, "c.11416G>A": 1}}	\N
7941923	7941119	c.3418C>T/c.7523G>A	{"RYR1": {"c.3418C>T": 1, "c.7523G>A": 1}}	\N
7941924	7941119	c.103T>C/c.8188G>C	{"RYR1": {"c.103T>C": 1, "c.8188G>C": 1}}	\N
7941925	7941119	c.1459C>G/c.11969G>T	{"RYR1": {"c.1459C>G": 1, "c.11969G>T": 1}}	\N
7941926	7941119	c.9868G>A/c.12700G>C	{"RYR1": {"c.9868G>A": 1, "c.12700G>C": 1}}	\N
7941927	7941119	c.11953T>C/c.14803G>A	{"RYR1": {"c.11953T>C": 1, "c.14803G>A": 1}}	\N
7941928	7941119	c.3172G>A/c.14545G>A	{"RYR1": {"c.3172G>A": 1, "c.14545G>A": 1}}	\N
7941929	7941119	c.1615T>C/c.3172G>A	{"RYR1": {"c.1615T>C": 1, "c.3172G>A": 1}}	\N
7941930	7941119	c.1021G>A/c.9268G>A	{"RYR1": {"c.1021G>A": 1, "c.9268G>A": 1}}	\N
7941931	7941119	c.9868G>A/c.12700G>T	{"RYR1": {"c.9868G>A": 1, "c.12700G>T": 1}}	\N
7941932	7941119	c.152C>A/c.1841G>T	{"RYR1": {"c.152C>A": 1, "c.1841G>T": 1}}	\N
7941933	7941119	c.212C>A/c.7522C>T	{"RYR1": {"c.212C>A": 1, "c.7522C>T": 1}}	\N
7941934	7941119	c.14449A>T/c.14627A>G	{"RYR1": {"c.14449A>T": 1, "c.14627A>G": 1}}	\N
7941935	7941119	c.488G>T/c.5132A>G	{"RYR1": {"c.488G>T": 1, "c.5132A>G": 1}}	\N
7941936	7941119	c.1453A>G/c.6628G>T	{"RYR1": {"c.1453A>G": 1, "c.6628G>T": 1}}	\N
7941937	7941119	c.6743G>A/c.11315G>A	{"RYR1": {"c.6743G>A": 1, "c.11315G>A": 1}}	\N
7941938	7941119	c.982C>T/c.14818G>A	{"RYR1": {"c.982C>T": 1, "c.14818G>A": 1}}	\N
7941939	7941119	c.6488G>A/c.9152G>A	{"RYR1": {"c.6488G>A": 1, "c.9152G>A": 1}}	\N
7941940	7941119	c.1615T>G/c.6377G>A	{"RYR1": {"c.1615T>G": 1, "c.6377G>A": 1}}	\N
7941941	7941119	c.2122G>A/c.14497C>T	{"RYR1": {"c.2122G>A": 1, "c.14497C>T": 1}}	\N
7941942	7941119	c.488G>A/c.1201C>T	{"RYR1": {"c.488G>A": 1, "c.1201C>T": 1}}	\N
7941943	7941119	c.1565A>G/c.14197T>G	{"RYR1": {"c.1565A>G": 1, "c.14197T>G": 1}}	\N
7941944	7941119	c.7777C>G/c.11708G>A	{"RYR1": {"c.7777C>G": 1, "c.11708G>A": 1}}	\N
7941945	7941119	c.7060G>A/c.14680G>A	{"RYR1": {"c.7060G>A": 1, "c.14680G>A": 1}}	\N
7941946	7941119	c.4763C>T/c.6488G>C	{"RYR1": {"c.4763C>T": 1, "c.6488G>C": 1}}	\N
7941947	7941119	c.2122G>A/c.14210G>A	{"RYR1": {"c.2122G>A": 1, "c.14210G>A": 1}}	\N
7941948	7941119	c.7090T>G/c.13760C>T	{"RYR1": {"c.7090T>G": 1, "c.13760C>T": 1}}	\N
7941949	7941119	c.4763C>T/c.6488G>A	{"RYR1": {"c.4763C>T": 1, "c.6488G>A": 1}}	\N
7941950	7941119	c.3172G>A/c.12700G>T	{"RYR1": {"c.3172G>A": 1, "c.12700G>T": 1}}	\N
7941951	7941119	c.7060G>A/c.14424C>A	{"RYR1": {"c.7060G>A": 1, "c.14424C>A": 1}}	\N
7941952	7941119	c.7291G>A/c.11126C>T	{"RYR1": {"c.7291G>A": 1, "c.11126C>T": 1}}	\N
7941953	7941119	c.7879G>A/c.11708G>A	{"RYR1": {"c.7879G>A": 1, "c.11708G>A": 1}}	\N
7941954	7941119	c.7048G>A/c.7879G>A	{"RYR1": {"c.7048G>A": 1, "c.7879G>A": 1}}	\N
7941955	7941119	c.6349G>C/c.14387A>G	{"RYR1": {"c.6349G>C": 1, "c.14387A>G": 1}}	\N
7941956	7941119	c.6387C>G/c.9758T>C	{"RYR1": {"c.6387C>G": 1, "c.9758T>C": 1}}	\N
7941957	7941119	c.11958C>G/c.12700G>T	{"RYR1": {"c.11958C>G": 1, "c.12700G>T": 1}}	\N
7941958	7941119	c.1630G>T/c.12533G>T	{"RYR1": {"c.1630G>T": 1, "c.12533G>T": 1}}	\N
7941959	7941119	c.14209C>T/c.14678G>A	{"RYR1": {"c.14209C>T": 1, "c.14678G>A": 1}}	\N
7941960	7941119	c.7007G>A/c.7085A>G	{"RYR1": {"c.7007G>A": 1, "c.7085A>G": 1}}	\N
7941961	7941119	c.7373G>T/c.11416G>A	{"RYR1": {"c.7373G>T": 1, "c.11416G>A": 1}}	\N
7941962	7941119	c.97A>G/c.2050G>C	{"RYR1": {"c.97A>G": 1, "c.2050G>C": 1}}	\N
7941963	7941119	c.7310C>T/c.14558C>T	{"RYR1": {"c.7310C>T": 1, "c.14558C>T": 1}}	\N
7941964	7941119	c.7199A>G/c.11969G>T	{"RYR1": {"c.7199A>G": 1, "c.11969G>T": 1}}	\N
7941965	7941119	c.6617C>G/c.12028G>A	{"RYR1": {"c.6617C>G": 1, "c.12028G>A": 1}}	\N
7941966	7941119	c.7300G>A/c.14449A>T	{"RYR1": {"c.7300G>A": 1, "c.14449A>T": 1}}	\N
7941967	7941119	c.9310G>A/c.14813T>C	{"RYR1": {"c.9310G>A": 1, "c.14813T>C": 1}}	\N
7941968	7941119	c.3172G>A/c.12700G>C	{"RYR1": {"c.3172G>A": 1, "c.12700G>C": 1}}	\N
7941969	7941119	c.1565A>G/c.4747C>T	{"RYR1": {"c.1565A>G": 1, "c.4747C>T": 1}}	\N
7941970	7941119	c.7124G>C/c.9676G>C	{"RYR1": {"c.7124G>C": 1, "c.9676G>C": 1}}	\N
7941971	7941119	c.6628G>T/c.12383C>T	{"RYR1": {"c.6628G>T": 1, "c.12383C>T": 1}}	\N
7941972	7941119	c.7282G>A/c.10891G>T	{"RYR1": {"c.7282G>A": 1, "c.10891G>T": 1}}	\N
7941973	7941119	c.6377G>A/c.7354C>T	{"RYR1": {"c.6377G>A": 1, "c.7354C>T": 1}}	\N
7941974	7941119	c.6304G>C/c.7123G>A	{"RYR1": {"c.6304G>C": 1, "c.7123G>A": 1}}	\N
7941975	7941119	c.7089C>G/c.7124G>C	{"RYR1": {"c.7089C>G": 1, "c.7124G>C": 1}}	\N
7941976	7941119	c.7372C>T/c.13673G>A	{"RYR1": {"c.7372C>T": 1, "c.13673G>A": 1}}	\N
7941977	7941119	c.11708G>A/c.12533G>T	{"RYR1": {"c.11708G>A": 1, "c.12533G>T": 1}}	\N
7941978	7941119	c.6628G>T/c.9649T>C	{"RYR1": {"c.6628G>T": 1, "c.9649T>C": 1}}	\N
7941979	7941119	c.493G>A/c.3166G>C	{"RYR1": {"c.493G>A": 1, "c.3166G>C": 1}}	\N
7941980	7941119	c.11958C>G/c.12700G>C	{"RYR1": {"c.11958C>G": 1, "c.12700G>C": 1}}	\N
7941981	7941119	c.528G>T/c.14209C>T	{"RYR1": {"c.528G>T": 1, "c.14209C>T": 1}}	\N
7941982	7941119	c.6612C>G/c.6710G>A	{"RYR1": {"c.6612C>G": 1, "c.6710G>A": 1}}	\N
7941983	7941119	c.1840C>T/c.5186T>G	{"RYR1": {"c.1840C>T": 1, "c.5186T>G": 1}}	\N
7941984	7941119	c.529C>T/c.14782A>G	{"RYR1": {"c.529C>T": 1, "c.14782A>G": 1}}	\N
7941985	7941119	c.8290G>A/c.11708G>A	{"RYR1": {"c.8290G>A": 1, "c.11708G>A": 1}}	\N
7941986	7941119	c.251C>T/c.1201C>T	{"RYR1": {"c.251C>T": 1, "c.1201C>T": 1}}	\N
7941987	7941119	c.6488G>C/c.9152G>A	{"RYR1": {"c.6488G>C": 1, "c.9152G>A": 1}}	\N
7941988	7941119	c.6487C>T/c.7778G>A	{"RYR1": {"c.6487C>T": 1, "c.7778G>A": 1}}	\N
7941989	7941119	c.7373G>A/c.12848A>T	{"RYR1": {"c.7373G>A": 1, "c.12848A>T": 1}}	\N
7941990	7941119	c.6743G>A/c.14210G>A	{"RYR1": {"c.6743G>A": 1, "c.14210G>A": 1}}	\N
7941991	7941119	c.1459C>G/c.14477C>T	{"RYR1": {"c.1459C>G": 1, "c.14477C>T": 1}}	\N
7941992	7941119	c.7522C>T/c.8518C>T	{"RYR1": {"c.7522C>T": 1, "c.8518C>T": 1}}	\N
7941993	7941119	c.7777C>G/c.9310G>A	{"RYR1": {"c.7777C>G": 1, "c.9310G>A": 1}}	\N
7941994	7941119	c.1202G>A/c.9676G>C	{"RYR1": {"c.1202G>A": 1, "c.9676G>C": 1}}	\N
7941995	7941119	c.1615T>C/c.14051T>C	{"RYR1": {"c.1615T>C": 1, "c.14051T>C": 1}}	\N
7941996	7941119	c.7360C>T/c.12383C>T	{"RYR1": {"c.7360C>T": 1, "c.12383C>T": 1}}	\N
7941997	7941119	c.1589G>A/c.1598G>A	{"RYR1": {"c.1589G>A": 1, "c.1598G>A": 1}}	\N
7941998	7941119	c.529C>T/c.7199A>G	{"RYR1": {"c.529C>T": 1, "c.7199A>G": 1}}	\N
7941999	7941119	c.8054C>T/c.14627A>G	{"RYR1": {"c.8054C>T": 1, "c.14627A>G": 1}}	\N
7942000	7941119	c.7007G>A/c.14825G>T	{"RYR1": {"c.7007G>A": 1, "c.14825G>T": 1}}	\N
7942001	7941119	c.6628G>T/c.7089C>G	{"RYR1": {"c.6628G>T": 1, "c.7089C>G": 1}}	\N
7942002	7941119	c.7879G>A/c.9310G>A	{"RYR1": {"c.7879G>A": 1, "c.9310G>A": 1}}	\N
7942003	7941119	c.9676G>C/c.14918C>T	{"RYR1": {"c.9676G>C": 1, "c.14918C>T": 1}}	\N
7942004	7941119	c.1202G>T/c.7099G>A	{"RYR1": {"c.1202G>T": 1, "c.7099G>A": 1}}	\N
7942005	7941119	c.251C>T/c.7291G>A	{"RYR1": {"c.251C>T": 1, "c.7291G>A": 1}}	\N
7942006	7941119	c.1840C>T/c.3527C>T	{"RYR1": {"c.1840C>T": 1, "c.3527C>T": 1}}	\N
7942007	7941119	c.6710G>A/c.7282G>A	{"RYR1": {"c.6710G>A": 1, "c.7282G>A": 1}}	\N
7942008	7941119	c.12848A>T/c.14627A>G	{"RYR1": {"c.12848A>T": 1, "c.14627A>G": 1}}	\N
7942009	7941119	c.641C>T/c.11708G>A	{"RYR1": {"c.641C>T": 1, "c.11708G>A": 1}}	\N
7942010	7941119	c.130C>T/c.13913G>A	{"RYR1": {"c.130C>T": 1, "c.13913G>A": 1}}	\N
7942011	7941119	c.130C>T/c.7487C>T	{"RYR1": {"c.130C>T": 1, "c.7487C>T": 1}}	\N
7942012	7941119	c.1615T>G/c.11416G>A	{"RYR1": {"c.1615T>G": 1, "c.11416G>A": 1}}	\N
7942013	7941119	c.8527T>C/c.12149C>A	{"RYR1": {"c.8527T>C": 1, "c.12149C>A": 1}}	\N
7942014	7941119	c.1201C>G/c.7282G>A	{"RYR1": {"c.1201C>G": 1, "c.7282G>A": 1}}	\N
7942015	7941119	c.493G>A/c.7373G>A	{"RYR1": {"c.493G>A": 1, "c.7373G>A": 1}}	\N
7942016	7941119	c.14458G>T/c.14545G>A	{"RYR1": {"c.14458G>T": 1, "c.14545G>A": 1}}	\N
7942017	7941119	c.1460T>C/c.1654C>T	{"RYR1": {"c.1460T>C": 1, "c.1654C>T": 1}}	\N
7942018	7941119	c.7084G>A/c.7097C>G	{"RYR1": {"c.7084G>A": 1, "c.7097C>G": 1}}	\N
7942019	7941119	c.7291G>A/c.12355A>T	{"RYR1": {"c.7291G>A": 1, "c.12355A>T": 1}}	\N
7942020	7941119	c.7373G>T/c.14051T>C	{"RYR1": {"c.7373G>T": 1, "c.14051T>C": 1}}	\N
7942021	7941119	c.7522C>G/c.14512C>G	{"RYR1": {"c.7522C>G": 1, "c.14512C>G": 1}}	\N
7942022	7941119	c.6488G>A/c.14197T>G	{"RYR1": {"c.6488G>A": 1, "c.14197T>G": 1}}	\N
7942023	7941119	c.493G>A/c.7373G>T	{"RYR1": {"c.493G>A": 1, "c.7373G>T": 1}}	\N
7942024	7941119	c.12149C>A/c.14364+1G>T	{"RYR1": {"c.12149C>A": 1, "c.14364+1G>T": 1}}	\N
7942025	7941119	c.190T>C/c.6612C>G	{"RYR1": {"c.190T>C": 1, "c.6612C>G": 1}}	\N
7942026	7941119	c.1654C>T/c.13990T>C	{"RYR1": {"c.1654C>T": 1, "c.13990T>C": 1}}	\N
7942027	7941119	c.455C>A/c.12700G>C	{"RYR1": {"c.455C>A": 1, "c.12700G>C": 1}}	\N
7942028	7941119	c.7042_7044delGAG/c.11723A>T	{"RYR1": {"c.11723A>T": 1, "c.7042_7044delGAG": 1}}	\N
7942029	7941119	c.8026C>T/c.12355A>T	{"RYR1": {"c.8026C>T": 1, "c.12355A>T": 1}}	\N
7942030	7941119	c.2654G>A/c.9310G>A	{"RYR1": {"c.2654G>A": 1, "c.9310G>A": 1}}	\N
7942031	7941119	c.7361G>A/c.14471T>C	{"RYR1": {"c.7361G>A": 1, "c.14471T>C": 1}}	\N
7942032	7941119	c.13913G>A/c.14497C>T	{"RYR1": {"c.13913G>A": 1, "c.14497C>T": 1}}	\N
7942033	7941119	c.7304G>T/c.14002C>T	{"RYR1": {"c.7304G>T": 1, "c.14002C>T": 1}}	\N
7942034	7941119	c.1654C>T/c.6544A>T	{"RYR1": {"c.1654C>T": 1, "c.6544A>T": 1}}	\N
7942035	7941119	c.1422G>T/c.6488G>T	{"RYR1": {"c.1422G>T": 1, "c.6488G>T": 1}}	\N
7942036	7941119	c.7522C>T/c.13934G>A	{"RYR1": {"c.7522C>T": 1, "c.13934G>A": 1}}	\N
7942037	7941119	c.1202G>A/c.5186T>G	{"RYR1": {"c.1202G>A": 1, "c.5186T>G": 1}}	\N
7942038	7941119	c.9499C>T/c.14477C>T	{"RYR1": {"c.9499C>T": 1, "c.14477C>T": 1}}	\N
7942039	7941119	c.992_994dup/c.1202G>A	{"RYR1": {"c.1202G>A": 1, "c.992_994dup": 1}}	\N
7942040	7941119	c.11314C>T/c.14209C>T	{"RYR1": {"c.11314C>T": 1, "c.14209C>T": 1}}	\N
7942041	7941119	c.7048G>A/c.10556C>T	{"RYR1": {"c.7048G>A": 1, "c.10556C>T": 1}}	\N
7942042	7941119	c.1565A>C/c.7089C>G	{"RYR1": {"c.1565A>C": 1, "c.7089C>G": 1}}	\N
7942043	7941119	c.1615T>G/c.15060G>C	{"RYR1": {"c.1615T>G": 1, "c.15060G>C": 1}}	\N
7942044	7941119	c.7123G>A/c.12121C>T	{"RYR1": {"c.7123G>A": 1, "c.12121C>T": 1}}	\N
7942045	7941119	c.455C>A/c.12700G>T	{"RYR1": {"c.455C>A": 1, "c.12700G>T": 1}}	\N
7942046	7941119	c.11315G>A/c.14581C>T	{"RYR1": {"c.11315G>A": 1, "c.14581C>T": 1}}	\N
7942047	7941119	c.1021G>C/c.5132A>G	{"RYR1": {"c.1021G>C": 1, "c.5132A>G": 1}}	\N
7942048	7941119	c.1597C>T/c.14458G>T	{"RYR1": {"c.1597C>T": 1, "c.14458G>T": 1}}	\N
7942049	7941119	c.6488G>T/c.9848G>A	{"RYR1": {"c.6488G>T": 1, "c.9848G>A": 1}}	\N
7942050	7941119	c.97A>G/c.190T>C	{"RYR1": {"c.97A>G": 1, "c.190T>C": 1}}	\N
7942051	7941119	c.10042C>T/c.12149C>A	{"RYR1": {"c.10042C>T": 1, "c.12149C>A": 1}}	\N
7942052	7941119	c.2050G>C/c.6487C>T	{"RYR1": {"c.2050G>C": 1, "c.6487C>T": 1}}	\N
7942053	7941119	c.6612C>G/c.9652G>A	{"RYR1": {"c.6612C>G": 1, "c.9652G>A": 1}}	\N
7942054	7941119	c.3172G>A/c.7060G>A	{"RYR1": {"c.3172G>A": 1, "c.7060G>A": 1}}	\N
7942055	7941119	c.467G>A/c.11708G>A	{"RYR1": {"c.467G>A": 1, "c.11708G>A": 1}}	\N
7942056	7941119	c.7060G>A/c.10229C>A	{"RYR1": {"c.7060G>A": 1, "c.10229C>A": 1}}	\N
7942057	7941119	c.190T>C/c.14918C>T	{"RYR1": {"c.190T>C": 1, "c.14918C>T": 1}}	\N
7942058	7941119	c.251C>T/c.1615T>G	{"RYR1": {"c.251C>T": 1, "c.1615T>G": 1}}	\N
7942059	7941119	c.1597C>T/c.14458G>A	{"RYR1": {"c.1597C>T": 1, "c.14458G>A": 1}}	\N
7942060	7941119	c.7075C>T/c.7090T>G	{"RYR1": {"c.7075C>T": 1, "c.7090T>G": 1}}	\N
7942061	7941119	c.251C>T/c.1615T>C	{"RYR1": {"c.251C>T": 1, "c.1615T>C": 1}}	\N
7942062	7941119	c.455C>A/c.7084G>A	{"RYR1": {"c.455C>A": 1, "c.7084G>A": 1}}	\N
7942063	7941119	c.14210G>A/c.14422_14423delinsAA	{"RYR1": {"c.14210G>A": 1, "c.14422_14423delinsAA": 1}}	\N
7942064	7941119	c.1565A>G/c.8527T>C	{"RYR1": {"c.1565A>G": 1, "c.8527T>C": 1}}	\N
7942065	7941119	c.7300G>A/c.7385C>T	{"RYR1": {"c.7300G>A": 1, "c.7385C>T": 1}}	\N
7942066	7941119	c.7304G>A/c.11132C>T	{"RYR1": {"c.7304G>A": 1, "c.11132C>T": 1}}	\N
7942067	7941119	c.6487C>T/c.12553G>A	{"RYR1": {"c.6487C>T": 1, "c.12553G>A": 1}}	\N
7942068	7941119	c.1202G>T/c.14126C>T	{"RYR1": {"c.1202G>T": 1, "c.14126C>T": 1}}	\N
7942069	7941119	c.742G>A/c.11958C>G	{"RYR1": {"c.742G>A": 1, "c.11958C>G": 1}}	\N
7942070	7941119	c.3656A>C/c.7879G>C	{"RYR1": {"c.3656A>C": 1, "c.7879G>C": 1}}	\N
7942071	7941119	c.1654C>T/c.7210G>A	{"RYR1": {"c.1654C>T": 1, "c.7210G>A": 1}}	\N
7942072	7941119	c.7063C>T/c.14387A>G	{"RYR1": {"c.7063C>T": 1, "c.14387A>G": 1}}	\N
7942073	7941119	c.1422G>T/c.6488G>C	{"RYR1": {"c.1422G>T": 1, "c.6488G>C": 1}}	\N
7942074	7941119	c.680A>T/c.7124G>C	{"RYR1": {"c.680A>T": 1, "c.7124G>C": 1}}	\N
7942075	7941119	c.6488G>C/c.14197T>G	{"RYR1": {"c.6488G>C": 1, "c.14197T>G": 1}}	\N
7942076	7941119	c.6388G>A/c.14539G>C	{"RYR1": {"c.6388G>A": 1, "c.14539G>C": 1}}	\N
7942077	7941119	c.1422G>T/c.6488G>A	{"RYR1": {"c.1422G>T": 1, "c.6488G>A": 1}}	\N
7942078	7941119	c.3667G>A/c.7042_7044delGAG	{"RYR1": {"c.3667G>A": 1, "c.7042_7044delGAG": 1}}	\N
7942079	7941119	c.13760C>T/c.14209C>T	{"RYR1": {"c.13760C>T": 1, "c.14209C>T": 1}}	\N
7942080	7941119	c.7063C>T/c.14678G>A	{"RYR1": {"c.7063C>T": 1, "c.14678G>A": 1}}	\N
7942081	7941119	c.7373G>T/c.7760A>G	{"RYR1": {"c.7373G>T": 1, "c.7760A>G": 1}}	\N
7942082	7941119	c.7090T>G/c.12532G>A	{"RYR1": {"c.7090T>G": 1, "c.12532G>A": 1}}	\N
7942083	7941119	c.982C>T/c.6548G>A	{"RYR1": {"c.982C>T": 1, "c.6548G>A": 1}}	\N
7942084	7941119	c.6617C>T/c.8638G>A	{"RYR1": {"c.6617C>T": 1, "c.8638G>A": 1}}	\N
7942085	7941119	c.1654C>T/c.14364+1G>T	{"RYR1": {"c.1654C>T": 1, "c.14364+1G>T": 1}}	\N
7942086	7941119	c.742G>C/c.14364+1G>T	{"RYR1": {"c.742G>C": 1, "c.14364+1G>T": 1}}	\N
7942087	7941119	c.1202G>T/c.7879G>A	{"RYR1": {"c.1202G>T": 1, "c.7879G>A": 1}}	\N
7942088	7941119	c.1615T>G/c.15059G>C	{"RYR1": {"c.1615T>G": 1, "c.15059G>C": 1}}	\N
7942089	7941119	c.7787C>T/c.14803G>A	{"RYR1": {"c.7787C>T": 1, "c.14803G>A": 1}}	\N
7942090	7941119	c.7124G>C/c.12064A>G	{"RYR1": {"c.7124G>C": 1, "c.12064A>G": 1}}	\N
7942091	7941119	c.7522C>T/c.14968A>G	{"RYR1": {"c.7522C>T": 1, "c.14968A>G": 1}}	\N
7942092	7941119	c.7199A>G/c.8026C>T	{"RYR1": {"c.7199A>G": 1, "c.8026C>T": 1}}	\N
7942093	7941119	c.7036G>A/c.8638G>A	{"RYR1": {"c.7036G>A": 1, "c.8638G>A": 1}}	\N
7942094	7941119	c.6488G>C/c.12115A>T	{"RYR1": {"c.6488G>C": 1, "c.12115A>T": 1}}	\N
7942095	7941119	c.4763C>T/c.6488G>T	{"RYR1": {"c.4763C>T": 1, "c.6488G>T": 1}}	\N
7942096	7941119	c.1615T>G/c.8005G>A	{"RYR1": {"c.1615T>G": 1, "c.8005G>A": 1}}	\N
7942097	7941119	c.742G>C/c.11958C>G	{"RYR1": {"c.742G>C": 1, "c.11958C>G": 1}}	\N
7942098	7941119	c.1202G>T/c.7085A>G	{"RYR1": {"c.1202G>T": 1, "c.7085A>G": 1}}	\N
7942099	7941119	c.1565A>C/c.9499C>T	{"RYR1": {"c.1565A>C": 1, "c.9499C>T": 1}}	\N
7942100	7941119	c.4747C>T/c.7048G>A	{"RYR1": {"c.4747C>T": 1, "c.7048G>A": 1}}	\N
7942101	7941119	c.1202G>T/c.2924G>A	{"RYR1": {"c.1202G>T": 1, "c.2924G>A": 1}}	\N
7942102	7941119	c.2122G>A/c.7090T>G	{"RYR1": {"c.2122G>A": 1, "c.7090T>G": 1}}	\N
7942103	7941119	c.7291G>A/c.10042C>T	{"RYR1": {"c.7291G>A": 1, "c.10042C>T": 1}}	\N
7942104	7941119	c.1565A>C/c.8005G>A	{"RYR1": {"c.1565A>C": 1, "c.8005G>A": 1}}	\N
7942105	7941119	c.8005G>A/c.11969G>T	{"RYR1": {"c.8005G>A": 1, "c.11969G>T": 1}}	\N
7942106	7941119	c.526G>A/c.1654C>T	{"RYR1": {"c.526G>A": 1, "c.1654C>T": 1}}	\N
7942107	7941119	c.6847A>C/c.7304G>T	{"RYR1": {"c.6847A>C": 1, "c.7304G>T": 1}}	\N
7942108	7941119	c.7354C>T/c.12553G>A	{"RYR1": {"c.7354C>T": 1, "c.12553G>A": 1}}	\N
7942109	7941119	c.6488G>A/c.8654C>G	{"RYR1": {"c.6488G>A": 1, "c.8654C>G": 1}}	\N
7942110	7941119	c.1565A>G/c.7089C>G	{"RYR1": {"c.1565A>G": 1, "c.7089C>G": 1}}	\N
7942111	7941119	c.6847A>C/c.7304G>A	{"RYR1": {"c.6847A>C": 1, "c.7304G>A": 1}}	\N
7942112	7941119	c.6349G>C/c.13505A>G	{"RYR1": {"c.6349G>C": 1, "c.13505A>G": 1}}	\N
7942113	7941119	c.13994_13995delTCinsCT/c.14209C>T	{"RYR1": {"c.14209C>T": 1, "c.13994_13995delTCinsCT": 1}}	\N
7942114	7941119	c.455C>A/c.7060G>A	{"RYR1": {"c.455C>A": 1, "c.7060G>A": 1}}	\N
7942115	7941119	c.1565A>G/c.7317G>C	{"RYR1": {"c.1565A>G": 1, "c.7317G>C": 1}}	\N
7942116	7941119	c.1565A>C/c.15059G>C	{"RYR1": {"c.1565A>C": 1, "c.15059G>C": 1}}	\N
7942117	7941119	c.7123G>A/c.14567C>G	{"RYR1": {"c.7123G>A": 1, "c.14567C>G": 1}}	\N
7942118	7941119	c.5440A>G/c.14512C>G	{"RYR1": {"c.5440A>G": 1, "c.14512C>G": 1}}	\N
7942119	7941119	c.487C>T/c.10042C>T	{"RYR1": {"c.487C>T": 1, "c.10042C>T": 1}}	\N
7942120	7941119	c.487C>T/c.7760A>G	{"RYR1": {"c.487C>T": 1, "c.7760A>G": 1}}	\N
7942121	7941119	c.103T>C/c.9499C>T	{"RYR1": {"c.103T>C": 1, "c.9499C>T": 1}}	\N
7942122	7941119	c.10043G>A/c.14497C>T	{"RYR1": {"c.10043G>A": 1, "c.14497C>T": 1}}	\N
7942123	7941119	c.742G>C/c.7210G>A	{"RYR1": {"c.742G>C": 1, "c.7210G>A": 1}}	\N
7942124	7941119	c.7060G>A/c.11723A>T	{"RYR1": {"c.7060G>A": 1, "c.11723A>T": 1}}	\N
7942125	7941119	c.6488G>A/c.12115A>T	{"RYR1": {"c.6488G>A": 1, "c.12115A>T": 1}}	\N
7942126	7941119	c.7291G>T/c.13934G>A	{"RYR1": {"c.7291G>T": 1, "c.13934G>A": 1}}	\N
7942127	7941119	c.742G>C/c.6544A>T	{"RYR1": {"c.742G>C": 1, "c.6544A>T": 1}}	\N
7942128	7941119	c.152C>A/c.7123G>A	{"RYR1": {"c.152C>A": 1, "c.7123G>A": 1}}	\N
7942129	7941119	c.6635T>A/c.14803G>A	{"RYR1": {"c.6635T>A": 1, "c.14803G>A": 1}}	\N
7942130	7941119	c.7354C>T/c.11958C>G	{"RYR1": {"c.7354C>T": 1, "c.11958C>G": 1}}	\N
7942131	7941119	c.1565A>C/c.15060G>C	{"RYR1": {"c.1565A>C": 1, "c.15060G>C": 1}}	\N
7942132	7941119	c.1209C>G/c.6502G>A	{"RYR1": {"c.1209C>G": 1, "c.6502G>A": 1}}	\N
7942133	7941119	c.1201C>A/c.7282G>A	{"RYR1": {"c.1201C>A": 1, "c.7282G>A": 1}}	\N
7942134	7941119	c.3127C>T/c.6502G>A	{"RYR1": {"c.3127C>T": 1, "c.6502G>A": 1}}	\N
7942135	7941119	c.7036G>A/c.11723A>T	{"RYR1": {"c.7036G>A": 1, "c.11723A>T": 1}}	\N
7942136	7941119	c.7063C>T/c.13760C>T	{"RYR1": {"c.7063C>T": 1, "c.13760C>T": 1}}	\N
7942137	7941119	c.5183C>T/c.10043G>A	{"RYR1": {"c.5183C>T": 1, "c.10043G>A": 1}}	\N
7942138	7941119	c.533A>G/c.6635T>A	{"RYR1": {"c.533A>G": 1, "c.6635T>A": 1}}	\N
7942139	7941119	c.7304G>T/c.10891G>T	{"RYR1": {"c.7304G>T": 1, "c.10891G>T": 1}}	\N
7942140	7941119	c.497A>G/c.7076G>A	{"RYR1": {"c.497A>G": 1, "c.7076G>A": 1}}	\N
7942141	7941119	c.7007G>A/c.14126C>T	{"RYR1": {"c.7007G>A": 1, "c.14126C>T": 1}}	\N
7942142	7941119	c.7358T>C/c.14693T>C	{"RYR1": {"c.7358T>C": 1, "c.14693T>C": 1}}	\N
7942143	7941119	c.6488G>C/c.8054C>T	{"RYR1": {"c.6488G>C": 1, "c.8054C>T": 1}}	\N
7942144	7941119	c.6617C>G/c.8290G>A	{"RYR1": {"c.6617C>G": 1, "c.8290G>A": 1}}	\N
7942145	7941119	c.6388G>A/c.7358T>C	{"RYR1": {"c.6388G>A": 1, "c.7358T>C": 1}}	\N
7942146	7941119	c.7036G>A/c.14558C>T	{"RYR1": {"c.7036G>A": 1, "c.14558C>T": 1}}	\N
7942147	7941119	c.130C>T/c.7528T>C	{"RYR1": {"c.130C>T": 1, "c.7528T>C": 1}}	\N
7942148	7941119	c.14545G>A/c.14817C>A	{"RYR1": {"c.14545G>A": 1, "c.14817C>A": 1}}	\N
7942149	7941119	c.6488G>C/c.8654C>G	{"RYR1": {"c.6488G>C": 1, "c.8654C>G": 1}}	\N
7942150	7941119	c.5033A>G/c.7373G>T	{"RYR1": {"c.5033A>G": 1, "c.7373G>T": 1}}	\N
7942151	7941119	c.7300G>A/c.9868G>A	{"RYR1": {"c.7300G>A": 1, "c.9868G>A": 1}}	\N
7942152	7941119	c.7361G>A/c.12355A>T	{"RYR1": {"c.7361G>A": 1, "c.12355A>T": 1}}	\N
7942153	7941119	c.7036G>A/c.10750G>C	{"RYR1": {"c.7036G>A": 1, "c.10750G>C": 1}}	\N
7942154	7941119	c.7075C>T/c.14497C>T	{"RYR1": {"c.7075C>T": 1, "c.14497C>T": 1}}	\N
7942155	7941119	c.7360C>T/c.9848G>A	{"RYR1": {"c.7360C>T": 1, "c.9848G>A": 1}}	\N
7942156	7941119	c.6488G>T/c.7112A>G	{"RYR1": {"c.6488G>T": 1, "c.7112A>G": 1}}	\N
7942157	7941119	c.7523G>A/c.10750G>C	{"RYR1": {"c.7523G>A": 1, "c.10750G>C": 1}}	\N
7942158	7941119	c.1840C>T/c.7771C>G	{"RYR1": {"c.1840C>T": 1, "c.7771C>G": 1}}	\N
7942159	7941119	c.7291G>A/c.14968A>G	{"RYR1": {"c.7291G>A": 1, "c.14968A>G": 1}}	\N
7942160	7941119	c.1201C>G/c.11969G>T	{"RYR1": {"c.1201C>G": 1, "c.11969G>T": 1}}	\N
7942161	7941119	c.7282G>A/c.14002C>T	{"RYR1": {"c.7282G>A": 1, "c.14002C>T": 1}}	\N
7942162	7941119	c.5033A>G/c.7373G>A	{"RYR1": {"c.5033A>G": 1, "c.7373G>A": 1}}	\N
7942163	7941119	c.1615T>C/c.8005G>A	{"RYR1": {"c.1615T>C": 1, "c.8005G>A": 1}}	\N
7942164	7941119	c.992_994dup/c.1202G>T	{"RYR1": {"c.1202G>T": 1, "c.992_994dup": 1}}	\N
7942165	7941119	c.6377G>A/c.6488G>T	{"RYR1": {"c.6377G>A": 1, "c.6488G>T": 1}}	\N
7942166	7941119	c.742G>A/c.6544A>T	{"RYR1": {"c.742G>A": 1, "c.6544A>T": 1}}	\N
7942167	7941119	c.11958C>G/c.14627A>G	{"RYR1": {"c.11958C>G": 1, "c.14627A>G": 1}}	\N
7942168	7941119	c.2996G>A/c.14545G>A	{"RYR1": {"c.2996G>A": 1, "c.14545G>A": 1}}	\N
7942169	7941119	c.7099G>A/c.11708G>A	{"RYR1": {"c.7099G>A": 1, "c.11708G>A": 1}}	\N
7942170	7941119	c.1840C>T/c.7771C>T	{"RYR1": {"c.1840C>T": 1, "c.7771C>T": 1}}	\N
7942171	7941119	c.5440A>G/c.8026C>T	{"RYR1": {"c.5440A>G": 1, "c.8026C>T": 1}}	\N
7942172	7941119	c.7124G>C/c.14449A>T	{"RYR1": {"c.7124G>C": 1, "c.14449A>T": 1}}	\N
7942173	7941119	c.5183C>T/c.14201G>A	{"RYR1": {"c.5183C>T": 1, "c.14201G>A": 1}}	\N
7942174	7941119	c.1021G>A/c.3527C>T	{"RYR1": {"c.1021G>A": 1, "c.3527C>T": 1}}	\N
7942175	7941119	c.1459C>G/c.7123G>A	{"RYR1": {"c.1459C>G": 1, "c.7123G>A": 1}}	\N
7942176	7941119	c.7487C>T/c.8026C>T	{"RYR1": {"c.7487C>T": 1, "c.8026C>T": 1}}	\N
7942177	7941119	c.488G>T/c.3418C>T	{"RYR1": {"c.488G>T": 1, "c.3418C>T": 1}}	\N
7942178	7941119	c.6377G>A/c.6488G>C	{"RYR1": {"c.6377G>A": 1, "c.6488G>C": 1}}	\N
7942179	7941119	c.103T>C/c.8654C>G	{"RYR1": {"c.103T>C": 1, "c.8654C>G": 1}}	\N
7942180	7941119	c.6377G>A/c.6488G>A	{"RYR1": {"c.6377G>A": 1, "c.6488G>A": 1}}	\N
7942181	7941119	c.3172G>A/c.7300G>A	{"RYR1": {"c.3172G>A": 1, "c.7300G>A": 1}}	\N
7942182	7941119	c.5341T>C/c.11708G>A	{"RYR1": {"c.5341T>C": 1, "c.11708G>A": 1}}	\N
7942183	7941119	c.529C>T/c.9797T>C	{"RYR1": {"c.529C>T": 1, "c.9797T>C": 1}}	\N
7942184	7941119	c.1201C>A/c.11969G>T	{"RYR1": {"c.1201C>A": 1, "c.11969G>T": 1}}	\N
7942185	7941119	c.1202G>A/c.14449A>T	{"RYR1": {"c.1202G>A": 1, "c.14449A>T": 1}}	\N
7942186	7941119	c.1630G>T/c.5033A>G	{"RYR1": {"c.1630G>T": 1, "c.5033A>G": 1}}	\N
7942187	7941119	c.6488G>A/c.8054C>T	{"RYR1": {"c.6488G>A": 1, "c.8054C>T": 1}}	\N
7942188	7941119	c.6488G>T/c.9499C>T	{"RYR1": {"c.6488G>T": 1, "c.9499C>T": 1}}	\N
7942189	7941119	c.6488G>C/c.13673G>A	{"RYR1": {"c.6488G>C": 1, "c.13673G>A": 1}}	\N
7942190	7941119	c.7787C>T/c.11969G>T	{"RYR1": {"c.7787C>T": 1, "c.11969G>T": 1}}	\N
7942191	7941119	c.7048G>A/c.9652G>A	{"RYR1": {"c.7048G>A": 1, "c.9652G>A": 1}}	\N
7942192	7941119	c.5033A>G/c.7361G>A	{"RYR1": {"c.5033A>G": 1, "c.7361G>A": 1}}	\N
7942193	7941119	c.130C>T/c.533A>C	{"RYR1": {"c.130C>T": 1, "c.533A>C": 1}}	\N
7942194	7941119	c.1597C>T/c.10237A>T	{"RYR1": {"c.1597C>T": 1, "c.10237A>T": 1}}	\N
7942195	7941119	c.38T>G/c.680A>T	{"RYR1": {"c.38T>G": 1, "c.680A>T": 1}}	\N
7942196	7941119	c.6617C>T/c.11723A>T	{"RYR1": {"c.6617C>T": 1, "c.11723A>T": 1}}	\N
7942197	7941119	c.1565A>C/c.7317G>C	{"RYR1": {"c.1565A>C": 1, "c.7317G>C": 1}}	\N
7942198	7941119	c.641C>T/c.1630G>T	{"RYR1": {"c.641C>T": 1, "c.1630G>T": 1}}	\N
7942199	7941119	c.7373G>A/c.11416G>A	{"RYR1": {"c.7373G>A": 1, "c.11416G>A": 1}}	\N
7942200	7941119	c.1565A>C/c.9848G>A	{"RYR1": {"c.1565A>C": 1, "c.9848G>A": 1}}	\N
7942201	7941119	c.8189A>G/c.14918C>T	{"RYR1": {"c.8189A>G": 1, "c.14918C>T": 1}}	\N
7942202	7941119	c.1615T>G/c.2050G>C	{"RYR1": {"c.1615T>G": 1, "c.2050G>C": 1}}	\N
7942203	7941119	c.6487C>T/c.7199A>G	{"RYR1": {"c.6487C>T": 1, "c.7199A>G": 1}}	\N
7942204	7941119	c.1589G>A/c.8638G>A	{"RYR1": {"c.1589G>A": 1, "c.8638G>A": 1}}	\N
7942205	7941119	c.38T>G/c.1834G>C	{"RYR1": {"c.38T>G": 1, "c.1834G>C": 1}}	\N
7942206	7941119	c.1209C>G/c.6838G>A	{"RYR1": {"c.1209C>G": 1, "c.6838G>A": 1}}	\N
7942207	7941119	c.130C>T/c.13673G>A	{"RYR1": {"c.130C>T": 1, "c.13673G>A": 1}}	\N
7942208	7941119	c.7035C>A/c.14968A>G	{"RYR1": {"c.7035C>A": 1, "c.14968A>G": 1}}	\N
7942209	7941119	c.7300G>A/c.14680G>A	{"RYR1": {"c.7300G>A": 1, "c.14680G>A": 1}}	\N
7942210	7941119	c.1597C>A/c.7007G>A	{"RYR1": {"c.1597C>A": 1, "c.7007G>A": 1}}	\N
7942211	7941119	c.1021G>A/c.7771C>T	{"RYR1": {"c.1021G>A": 1, "c.7771C>T": 1}}	\N
7942212	7941119	c.7373G>T/c.8198G>A	{"RYR1": {"c.7373G>T": 1, "c.8198G>A": 1}}	\N
7942213	7941119	c.1834G>C/c.14545G>A	{"RYR1": {"c.1834G>C": 1, "c.14545G>A": 1}}	\N
7942214	7941119	c.1615T>G/c.14639T>C	{"RYR1": {"c.1615T>G": 1, "c.14639T>C": 1}}	\N
7942215	7941119	c.6635T>A/c.14539G>C	{"RYR1": {"c.6635T>A": 1, "c.14539G>C": 1}}	\N
7942216	7941119	c.488G>A/c.12149C>A	{"RYR1": {"c.488G>A": 1, "c.12149C>A": 1}}	\N
7942217	7941119	c.1654C>T/c.6635T>A	{"RYR1": {"c.1654C>T": 1, "c.6635T>A": 1}}	\N
7942218	7941119	c.982C>T/c.1475G>A	{"RYR1": {"c.982C>T": 1, "c.1475G>A": 1}}	\N
7942219	7941119	c.487C>T/c.11813G>A	{"RYR1": {"c.487C>T": 1, "c.11813G>A": 1}}	\N
7942220	7941119	c.1021G>C/c.3527C>T	{"RYR1": {"c.1021G>C": 1, "c.3527C>T": 1}}	\N
7942221	7941119	c.487C>T/c.6037A>C	{"RYR1": {"c.487C>T": 1, "c.6037A>C": 1}}	\N
7942222	7941119	c.6757C>T/c.6838G>A	{"RYR1": {"c.6757C>T": 1, "c.6838G>A": 1}}	\N
7942223	7941119	c.3166G>C/c.12028G>A	{"RYR1": {"c.3166G>C": 1, "c.12028G>A": 1}}	\N
7942224	7941119	c.1021G>A/c.7771C>G	{"RYR1": {"c.1021G>A": 1, "c.7771C>G": 1}}	\N
7942225	7941119	c.38T>G/c.14458G>A	{"RYR1": {"c.38T>G": 1, "c.14458G>A": 1}}	\N
7942226	7941119	c.38T>G/c.14458G>T	{"RYR1": {"c.38T>G": 1, "c.14458G>T": 1}}	\N
7942227	7941119	c.463C>A/c.652G>A	{"RYR1": {"c.463C>A": 1, "c.652G>A": 1}}	\N
7942228	7941119	c.7373G>A/c.14051T>C	{"RYR1": {"c.7373G>A": 1, "c.14051T>C": 1}}	\N
7942229	7941119	c.5440A>G/c.6387C>G	{"RYR1": {"c.5440A>G": 1, "c.6387C>G": 1}}	\N
7942230	7941119	c.1475G>A/c.7523G>A	{"RYR1": {"c.1475G>A": 1, "c.7523G>A": 1}}	\N
7942231	7941119	c.7084G>A/c.14680G>A	{"RYR1": {"c.7084G>A": 1, "c.14680G>A": 1}}	\N
7942232	7941119	c.212C>A/c.7007G>A	{"RYR1": {"c.212C>A": 1, "c.7007G>A": 1}}	\N
7942233	7941119	c.6488G>T/c.9649T>C	{"RYR1": {"c.6488G>T": 1, "c.9649T>C": 1}}	\N
7942234	7941119	c.131G>A/c.6628G>T	{"RYR1": {"c.131G>A": 1, "c.6628G>T": 1}}	\N
7942235	7941119	c.7090T>G/c.14387A>G	{"RYR1": {"c.7090T>G": 1, "c.14387A>G": 1}}	\N
7942236	7941119	c.7373G>A/c.13994_13995delTCinsCT	{"RYR1": {"c.7373G>A": 1, "c.13994_13995delTCinsCT": 1}}	\N
7942237	7941119	c.130C>T/c.11953T>C	{"RYR1": {"c.130C>T": 1, "c.11953T>C": 1}}	\N
7942238	7941119	c.152C>A/c.1589G>A	{"RYR1": {"c.152C>A": 1, "c.1589G>A": 1}}	\N
7942239	7941119	c.212C>A/c.488G>T	{"RYR1": {"c.212C>A": 1, "c.488G>T": 1}}	\N
7942240	7941119	c.12553G>A/c.14545G>A	{"RYR1": {"c.12553G>A": 1, "c.14545G>A": 1}}	\N
7942241	7941119	c.1565A>C/c.7112A>G	{"RYR1": {"c.1565A>C": 1, "c.7112A>G": 1}}	\N
7942242	7941119	c.6037A>C/c.14512C>G	{"RYR1": {"c.6037A>C": 1, "c.14512C>G": 1}}	\N
7942243	7941119	c.7075C>T/c.14210G>A	{"RYR1": {"c.7075C>T": 1, "c.14210G>A": 1}}	\N
7942244	7941119	c.1840C>T/c.3418C>T	{"RYR1": {"c.1840C>T": 1, "c.3418C>T": 1}}	\N
7942245	7941119	c.7282G>A/c.14813T>C	{"RYR1": {"c.7282G>A": 1, "c.14813T>C": 1}}	\N
7942246	7941119	c.7372C>T/c.13913G>A	{"RYR1": {"c.7372C>T": 1, "c.13913G>A": 1}}	\N
7942247	7941119	c.7355G>A/c.11969G>T	{"RYR1": {"c.7355G>A": 1, "c.11969G>T": 1}}	\N
7942248	7941119	c.7291G>T/c.7292A>T	{"RYR1": {"c.7291G>T": 1, "c.7292A>T": 1}}	\N
7942249	7941119	c.6488G>T/c.7089C>G	{"RYR1": {"c.6488G>T": 1, "c.7089C>G": 1}}	\N
7942250	7941119	c.7310C>T/c.8926C>T	{"RYR1": {"c.7310C>T": 1, "c.8926C>T": 1}}	\N
7942251	7941119	c.14051T>C/c.14512C>G	{"RYR1": {"c.14051T>C": 1, "c.14512C>G": 1}}	\N
7942252	7941119	c.11315G>A/c.14678G>A	{"RYR1": {"c.11315G>A": 1, "c.14678G>A": 1}}	\N
7942253	7941119	c.1565A>G/c.14814C>G	{"RYR1": {"c.1565A>G": 1, "c.14814C>G": 1}}	\N
7942254	7941119	c.7361G>A/c.11126C>T	{"RYR1": {"c.7361G>A": 1, "c.11126C>T": 1}}	\N
7942255	7941119	c.11953T>C/c.14539G>C	{"RYR1": {"c.11953T>C": 1, "c.14539G>C": 1}}	\N
7942256	7941119	c.14458G>T/c.14627A>G	{"RYR1": {"c.14458G>T": 1, "c.14627A>G": 1}}	\N
7942257	7941119	c.982C>T/c.4763C>T	{"RYR1": {"c.982C>T": 1, "c.4763C>T": 1}}	\N
7942258	7941119	c.4747C>T/c.7361G>A	{"RYR1": {"c.4747C>T": 1, "c.7361G>A": 1}}	\N
7942259	7941119	c.1024G>A/c.6838G>A	{"RYR1": {"c.1024G>A": 1, "c.6838G>A": 1}}	\N
7942260	7941119	c.1100G>T/c.6838G>A	{"RYR1": {"c.1100G>T": 1, "c.6838G>A": 1}}	\N
7942261	7941119	c.8198G>A/c.14210G>A	{"RYR1": {"c.8198G>A": 1, "c.14210G>A": 1}}	\N
7942262	7941119	c.7372C>T/c.8188G>C	{"RYR1": {"c.7372C>T": 1, "c.8188G>C": 1}}	\N
7942263	7941119	c.7124G>C/c.7879G>A	{"RYR1": {"c.7124G>C": 1, "c.7879G>A": 1}}	\N
7942264	7941119	c.947G>T/c.6617C>G	{"RYR1": {"c.947G>T": 1, "c.6617C>G": 1}}	\N
7942265	7941119	c.7355G>C/c.7358T>C	{"RYR1": {"c.7355G>C": 1, "c.7358T>C": 1}}	\N
7942266	7941119	c.1615T>C/c.15060G>C	{"RYR1": {"c.1615T>C": 1, "c.15060G>C": 1}}	\N
7942267	7941119	c.190T>C/c.7048G>A	{"RYR1": {"c.190T>C": 1, "c.7048G>A": 1}}	\N
7942268	7941119	c.2537C>T/c.6349G>C	{"RYR1": {"c.2537C>T": 1, "c.6349G>C": 1}}	\N
7942269	7941119	c.947G>T/c.6617C>T	{"RYR1": {"c.947G>T": 1, "c.6617C>T": 1}}	\N
7942270	7941119	c.7075C>T/c.11315G>A	{"RYR1": {"c.7075C>T": 1, "c.11315G>A": 1}}	\N
7942271	7941119	c.7035C>A/c.8518C>T	{"RYR1": {"c.7035C>A": 1, "c.8518C>T": 1}}	\N
7942272	7941119	c.1565A>G/c.9848G>A	{"RYR1": {"c.1565A>G": 1, "c.9848G>A": 1}}	\N
7942273	7941119	c.9868G>A/c.14627A>G	{"RYR1": {"c.9868G>A": 1, "c.14627A>G": 1}}	\N
7942274	7941119	c.1615T>C/c.2050G>C	{"RYR1": {"c.1615T>C": 1, "c.2050G>C": 1}}	\N
7942275	7941119	c.1598G>A/c.6617C>G	{"RYR1": {"c.1598G>A": 1, "c.6617C>G": 1}}	\N
7942276	7941119	c.1202G>A/c.12064A>G	{"RYR1": {"c.1202G>A": 1, "c.12064A>G": 1}}	\N
7942277	7941119	c.7291G>T/c.12355A>T	{"RYR1": {"c.7291G>T": 1, "c.12355A>T": 1}}	\N
7942278	7941119	c.1615T>C/c.14639T>C	{"RYR1": {"c.1615T>C": 1, "c.14639T>C": 1}}	\N
7942279	7941119	c.152C>A/c.14477C>T	{"RYR1": {"c.152C>A": 1, "c.14477C>T": 1}}	\N
7942280	7941119	c.1598G>A/c.6617C>T	{"RYR1": {"c.1598G>A": 1, "c.6617C>T": 1}}	\N
7942281	7941119	c.6388G>A/c.14803G>A	{"RYR1": {"c.6388G>A": 1, "c.14803G>A": 1}}	\N
7942282	7941119	c.1841G>T/c.2996G>A	{"RYR1": {"c.1841G>T": 1, "c.2996G>A": 1}}	\N
7942283	7941119	c.6612C>G/c.9676G>C	{"RYR1": {"c.6612C>G": 1, "c.9676G>C": 1}}	\N
7942284	7941119	c.529C>T/c.7777C>G	{"RYR1": {"c.529C>T": 1, "c.7777C>G": 1}}	\N
7942285	7941119	c.1615T>C/c.15059G>C	{"RYR1": {"c.1615T>C": 1, "c.15059G>C": 1}}	\N
7942286	7941119	c.11969G>T/c.12115A>T	{"RYR1": {"c.11969G>T": 1, "c.12115A>T": 1}}	\N
7942287	7941119	c.455C>A/c.7300G>A	{"RYR1": {"c.455C>A": 1, "c.7300G>A": 1}}	\N
7942288	7941119	c.1202G>T/c.6757C>T	{"RYR1": {"c.1202G>T": 1, "c.6757C>T": 1}}	\N
7942289	7941119	c.7291G>T/c.14471T>C	{"RYR1": {"c.7291G>T": 1, "c.14471T>C": 1}}	\N
7942290	7941119	c.7361G>A/c.13934G>A	{"RYR1": {"c.7361G>A": 1, "c.13934G>A": 1}}	\N
7942291	7941119	c.982C>T/c.4775C>T	{"RYR1": {"c.982C>T": 1, "c.4775C>T": 1}}	\N
7942292	7941119	c.1615T>C/c.7317G>C	{"RYR1": {"c.1615T>C": 1, "c.7317G>C": 1}}	\N
7942293	7941119	c.7035C>A/c.14825G>T	{"RYR1": {"c.7035C>A": 1, "c.14825G>T": 1}}	\N
7942294	7941119	c.7372C>T/c.12689T>G	{"RYR1": {"c.7372C>T": 1, "c.12689T>G": 1}}	\N
7942295	7941119	c.533A>G/c.7355G>C	{"RYR1": {"c.533A>G": 1, "c.7355G>C": 1}}	\N
7942296	7941119	c.103T>C/c.13673G>A	{"RYR1": {"c.103T>C": 1, "c.13673G>A": 1}}	\N
7942297	7941119	c.7063C>T/c.14581C>T	{"RYR1": {"c.7063C>T": 1, "c.14581C>T": 1}}	\N
7942298	7941119	c.8026C>T/c.14471T>C	{"RYR1": {"c.8026C>T": 1, "c.14471T>C": 1}}	\N
7942299	7941119	c.533A>G/c.7355G>A	{"RYR1": {"c.533A>G": 1, "c.7355G>A": 1}}	\N
7942300	7941119	c.7879G>C/c.14818G>A	{"RYR1": {"c.7879G>C": 1, "c.14818G>A": 1}}	\N
7942301	7941119	c.2537C>T/c.14209C>T	{"RYR1": {"c.2537C>T": 1, "c.14209C>T": 1}}	\N
7942302	7941119	c.4747C>T/c.7036G>A	{"RYR1": {"c.4747C>T": 1, "c.7036G>A": 1}}	\N
7942303	7941119	c.7304G>A/c.10252A>G	{"RYR1": {"c.7304G>A": 1, "c.10252A>G": 1}}	\N
7942304	7941119	c.10043G>A/c.11315G>A	{"RYR1": {"c.10043G>A": 1, "c.11315G>A": 1}}	\N
7942305	7941119	c.7076G>A/c.7777C>G	{"RYR1": {"c.7076G>A": 1, "c.7777C>G": 1}}	\N
7942306	7941119	c.190T>C/c.7036G>A	{"RYR1": {"c.190T>C": 1, "c.7036G>A": 1}}	\N
7942307	7941119	c.6635T>A/c.7358T>C	{"RYR1": {"c.6635T>A": 1, "c.7358T>C": 1}}	\N
7942308	7941119	c.1202G>A/c.6710G>A	{"RYR1": {"c.1202G>A": 1, "c.6710G>A": 1}}	\N
7942309	7941119	c.14197T>G/c.14209C>T	{"RYR1": {"c.14197T>G": 1, "c.14209C>T": 1}}	\N
7942310	7941119	c.6488G>A/c.13673G>A	{"RYR1": {"c.6488G>A": 1, "c.13673G>A": 1}}	\N
7942311	7941119	c.6544A>T/c.9310G>A	{"RYR1": {"c.6544A>T": 1, "c.9310G>A": 1}}	\N
7942312	7941119	c.9310G>A/c.11086G>C	{"RYR1": {"c.9310G>A": 1, "c.11086G>C": 1}}	\N
7942313	7941119	c.13702C>G/c.14477C>T	{"RYR1": {"c.13702C>G": 1, "c.14477C>T": 1}}	\N
7942314	7941119	c.6612C>G/c.6757C>T	{"RYR1": {"c.6612C>G": 1, "c.6757C>T": 1}}	\N
7942315	7941119	c.496G>A/c.7522C>T	{"RYR1": {"c.496G>A": 1, "c.7522C>T": 1}}	\N
7942316	7941119	c.7355G>A/c.7358T>C	{"RYR1": {"c.7355G>A": 1, "c.7358T>C": 1}}	\N
7942317	7941119	c.1565A>G/c.7112A>G	{"RYR1": {"c.1565A>G": 1, "c.7112A>G": 1}}	\N
7942318	7941119	c.178G>T/c.6628G>T	{"RYR1": {"c.178G>T": 1, "c.6628G>T": 1}}	\N
7942319	7941119	c.131G>A/c.7304G>A	{"RYR1": {"c.131G>A": 1, "c.7304G>A": 1}}	\N
7942320	7941119	c.9310G>A/c.13760C>T	{"RYR1": {"c.9310G>A": 1, "c.13760C>T": 1}}	\N
7942321	7941119	c.1021G>A/c.5132A>G	{"RYR1": {"c.1021G>A": 1, "c.5132A>G": 1}}	\N
7942322	7941119	c.6617C>G/c.8638G>A	{"RYR1": {"c.6617C>G": 1, "c.8638G>A": 1}}	\N
7942323	7941119	c.6599C>T/c.7043A>G	{"RYR1": {"c.6599C>T": 1, "c.7043A>G": 1}}	\N
7942324	7941119	c.1615T>G/c.14814C>G	{"RYR1": {"c.1615T>G": 1, "c.14814C>G": 1}}	\N
7942325	7941119	c.119G>C/c.7358T>C	{"RYR1": {"c.119G>C": 1, "c.7358T>C": 1}}	\N
7942326	7941119	c.7043A>G/c.9797T>C	{"RYR1": {"c.7043A>G": 1, "c.9797T>C": 1}}	\N
7942327	7941119	c.1021G>C/c.7771C>T	{"RYR1": {"c.1021G>C": 1, "c.7771C>T": 1}}	\N
7942328	7941119	c.131G>A/c.7304G>T	{"RYR1": {"c.131G>A": 1, "c.7304G>T": 1}}	\N
7942329	7941119	c.7123G>A/c.12398A>G	{"RYR1": {"c.7123G>A": 1, "c.12398A>G": 1}}	\N
7942330	7941119	c.1840C>T/c.7097C>G	{"RYR1": {"c.1840C>T": 1, "c.7097C>G": 1}}	\N
7942331	7941119	c.3172G>A/c.7084G>A	{"RYR1": {"c.3172G>A": 1, "c.7084G>A": 1}}	\N
7942332	7941119	c.1615T>C/c.12848A>T	{"RYR1": {"c.1615T>C": 1, "c.12848A>T": 1}}	\N
7942333	7941119	c.38T>G/c.10237A>T	{"RYR1": {"c.38T>G": 1, "c.10237A>T": 1}}	\N
7942334	7941119	c.1565A>C/c.14814C>G	{"RYR1": {"c.1565A>C": 1, "c.14814C>G": 1}}	\N
7942335	7941119	c.467G>A/c.1630G>T	{"RYR1": {"c.467G>A": 1, "c.1630G>T": 1}}	\N
7942336	7941119	c.7760A>G/c.14627A>G	{"RYR1": {"c.7760A>G": 1, "c.14627A>G": 1}}	\N
7942337	7941119	c.488G>T/c.9268G>A	{"RYR1": {"c.488G>T": 1, "c.9268G>A": 1}}	\N
7942338	7941119	c.1021G>C/c.7771C>G	{"RYR1": {"c.1021G>C": 1, "c.7771C>G": 1}}	\N
7942339	7941119	c.7307G>A/c.14512C>G	{"RYR1": {"c.7307G>A": 1, "c.14512C>G": 1}}	\N
7942340	7941119	c.1100G>T/c.11708G>A	{"RYR1": {"c.1100G>T": 1, "c.11708G>A": 1}}	\N
7942341	7941119	c.455C>A/c.1597C>T	{"RYR1": {"c.455C>A": 1, "c.1597C>T": 1}}	\N
7942342	7941119	c.1411C>T/c.12149C>A	{"RYR1": {"c.1411C>T": 1, "c.12149C>A": 1}}	\N
7942343	7941119	c.1100G>T/c.1630G>T	{"RYR1": {"c.1100G>T": 1, "c.1630G>T": 1}}	\N
7942344	7941119	c.7048G>A/c.13702C>G	{"RYR1": {"c.7048G>A": 1, "c.13702C>G": 1}}	\N
7942345	7941119	c.3527C>T/c.7361G>A	{"RYR1": {"c.3527C>T": 1, "c.7361G>A": 1}}	\N
7942346	7941119	c.5024T>C/c.11708G>A	{"RYR1": {"c.5024T>C": 1, "c.11708G>A": 1}}	\N
7942347	7941119	c.7522C>G/c.11969G>T	{"RYR1": {"c.7522C>G": 1, "c.11969G>T": 1}}	\N
7942348	7941119	c.529C>T/c.14458G>T	{"RYR1": {"c.529C>T": 1, "c.14458G>T": 1}}	\N
7942349	7941119	c.8654C>G/c.12149C>A	{"RYR1": {"c.8654C>G": 1, "c.12149C>A": 1}}	\N
7942350	7941119	c.1202G>T/c.9676G>C	{"RYR1": {"c.1202G>T": 1, "c.9676G>C": 1}}	\N
7942351	7941119	c.11969G>T/c.12355A>T	{"RYR1": {"c.11969G>T": 1, "c.12355A>T": 1}}	\N
7942352	7941119	c.6387C>G/c.7787C>T	{"RYR1": {"c.6387C>G": 1, "c.7787C>T": 1}}	\N
7942353	7941119	c.1565A>C/c.13673G>A	{"RYR1": {"c.1565A>C": 1, "c.13673G>A": 1}}	\N
7942354	7941119	c.7199A>G/c.7304G>T	{"RYR1": {"c.7199A>G": 1, "c.7304G>T": 1}}	\N
7942355	7941119	c.14186A>C/c.14210G>A	{"RYR1": {"c.14186A>C": 1, "c.14210G>A": 1}}	\N
7942356	7941119	c.7373G>A/c.14814C>G	{"RYR1": {"c.7373G>A": 1, "c.14814C>G": 1}}	\N
7942357	7941119	c.14209C>T/c.14680G>A	{"RYR1": {"c.14209C>T": 1, "c.14680G>A": 1}}	\N
7942358	7941119	c.13702C>G/c.14539G>C	{"RYR1": {"c.13702C>G": 1, "c.14539G>C": 1}}	\N
7942359	7941119	c.1144C>A/c.6488G>T	{"RYR1": {"c.1144C>A": 1, "c.6488G>T": 1}}	\N
7942360	7941119	c.529C>T/c.14458G>A	{"RYR1": {"c.529C>T": 1, "c.14458G>A": 1}}	\N
7942361	7941119	c.7036G>A/c.10556C>T	{"RYR1": {"c.7036G>A": 1, "c.10556C>T": 1}}	\N
7942362	7941119	c.14803G>A/c.14813T>C	{"RYR1": {"c.14803G>A": 1, "c.14813T>C": 1}}	\N
7869818	7869334	*9x2/*146	{"CYP2D6": {"*146": 1, "*9x2": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7869819	7869334	*9x2/*145	{"CYP2D6": {"*145": 1, "*9x2": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7869820	7869334	*9x2/*142	{"CYP2D6": {"*142": 1, "*9x2": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7869821	7869334	*9x2/*141	{"CYP2D6": {"*141": 1, "*9x2": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7869822	7869334	*9x2/*140	{"CYP2D6": {"*140": 1, "*9x2": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7869823	7869334	*37/*41x2	{"CYP2D6": {"*37": 1, "*41x2": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": 0.0, "Near Eastern": 0.0, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7869824	7869334	*17/*43x2	{"CYP2D6": {"*17": 1, "*43x2": 1}}	{"Latino": null, "American": 0.000010539759, "European": 0.0, "Oceanian": null, "East Asian": 0.0, "Near Eastern": null, "Central/South Asian": 0.0, "Sub-Saharan African": 0.00038711375, "African American/Afro-Caribbean": 0.0}
7869825	7869334	*54/*61	{"CYP2D6": {"*54": 1, "*61": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": 0.0, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
7942363	7941119	c.742G>A/c.11953T>C	{"RYR1": {"c.742G>A": 1, "c.11953T>C": 1}}	\N
7942364	7941119	c.7036G>A/c.12533G>T	{"RYR1": {"c.7036G>A": 1, "c.12533G>T": 1}}	\N
7942365	7941119	c.6488G>T/c.14814C>G	{"RYR1": {"c.6488G>T": 1, "c.14814C>G": 1}}	\N
7942366	7941119	c.528G>T/c.6349G>C	{"RYR1": {"c.528G>T": 1, "c.6349G>C": 1}}	\N
7942367	7941119	c.11958C>G/c.14497C>T	{"RYR1": {"c.11958C>G": 1, "c.14497C>T": 1}}	\N
7942368	7941119	c.488G>A/c.7879G>C	{"RYR1": {"c.488G>A": 1, "c.7879G>C": 1}}	\N
7942369	7941119	c.97A>G/c.1144C>A	{"RYR1": {"c.97A>G": 1, "c.1144C>A": 1}}	\N
7942370	7941119	c.1840C>T/c.10556C>T	{"RYR1": {"c.1840C>T": 1, "c.10556C>T": 1}}	\N
7942371	7941119	c.1144C>A/c.6488G>C	{"RYR1": {"c.1144C>A": 1, "c.6488G>C": 1}}	\N
7942372	7941119	c.6302T>A/c.7007G>A	{"RYR1": {"c.6302T>A": 1, "c.7007G>A": 1}}	\N
7942373	7941119	c.1144C>A/c.6488G>A	{"RYR1": {"c.1144C>A": 1, "c.6488G>A": 1}}	\N
7942374	7941119	c.7073T>A/c.7300G>A	{"RYR1": {"c.7073T>A": 1, "c.7300G>A": 1}}	\N
7942375	7941119	c.4400A>G/c.6349G>C	{"RYR1": {"c.4400A>G": 1, "c.6349G>C": 1}}	\N
7942376	7941119	c.7123G>A/c.8189A>G	{"RYR1": {"c.7123G>A": 1, "c.8189A>G": 1}}	\N
7942377	7941119	c.12149C>A/c.13913G>A	{"RYR1": {"c.12149C>A": 1, "c.13913G>A": 1}}	\N
7942378	7941119	c.3166G>C/c.9635A>G	{"RYR1": {"c.3166G>C": 1, "c.9635A>G": 1}}	\N
7942379	7941119	c.11132C>T/c.14918C>T	{"RYR1": {"c.11132C>T": 1, "c.14918C>T": 1}}	\N
7942380	7941119	c.7879G>C/c.14422_14423delinsAA	{"RYR1": {"c.7879G>C": 1, "c.14422_14423delinsAA": 1}}	\N
7942381	7941119	c.6710G>A/c.7304G>T	{"RYR1": {"c.6710G>A": 1, "c.7304G>T": 1}}	\N
7942382	7941119	c.7035C>A/c.14201G>A	{"RYR1": {"c.7035C>A": 1, "c.14201G>A": 1}}	\N
7942383	7941119	c.7304G>A/c.11518G>A	{"RYR1": {"c.7304G>A": 1, "c.11518G>A": 1}}	\N
7942384	7941119	c.533A>C/c.7358T>C	{"RYR1": {"c.533A>C": 1, "c.7358T>C": 1}}	\N
7942385	7941119	c.8638G>A/c.11969G>T	{"RYR1": {"c.8638G>A": 1, "c.11969G>T": 1}}	\N
7942386	7941119	c.6612C>G/c.14680G>A	{"RYR1": {"c.6612C>G": 1, "c.14680G>A": 1}}	\N
7942387	7941119	c.526G>A/c.7043A>G	{"RYR1": {"c.526G>A": 1, "c.7043A>G": 1}}	\N
7942388	7941119	c.3166G>C/c.14270G>A	{"RYR1": {"c.3166G>C": 1, "c.14270G>A": 1}}	\N
7942389	7941119	c.14539G>C/c.14782A>G	{"RYR1": {"c.14539G>C": 1, "c.14782A>G": 1}}	\N
7942390	7941119	c.7373G>A/c.10043G>A	{"RYR1": {"c.7373G>A": 1, "c.10043G>A": 1}}	\N
7942391	7941119	c.3527C>T/c.7373G>T	{"RYR1": {"c.3527C>T": 1, "c.7373G>T": 1}}	\N
7942392	7941119	c.6710G>A/c.7304G>A	{"RYR1": {"c.6710G>A": 1, "c.7304G>A": 1}}	\N
7942393	7941119	c.496G>A/c.6617C>T	{"RYR1": {"c.496G>A": 1, "c.6617C>T": 1}}	\N
7942394	7941119	c.1834G>C/c.7084G>A	{"RYR1": {"c.1834G>C": 1, "c.7084G>A": 1}}	\N
7942395	7941119	c.7310C>T/c.7771C>G	{"RYR1": {"c.7310C>T": 1, "c.7771C>G": 1}}	\N
7942396	7941119	c.3527C>T/c.7373G>A	{"RYR1": {"c.3527C>T": 1, "c.7373G>A": 1}}	\N
7942397	7941119	c.2050G>C/c.6617C>T	{"RYR1": {"c.2050G>C": 1, "c.6617C>T": 1}}	\N
7942398	7941119	c.1202G>T/c.14509C>G	{"RYR1": {"c.1202G>T": 1, "c.14509C>G": 1}}	\N
7942399	7941119	c.9310G>A/c.14582G>A	{"RYR1": {"c.9310G>A": 1, "c.14582G>A": 1}}	\N
7942400	7941119	c.1834G>C/c.12700G>C	{"RYR1": {"c.1834G>C": 1, "c.12700G>C": 1}}	\N
7942401	7941119	c.1201C>G/c.1589G>A	{"RYR1": {"c.1201C>G": 1, "c.1589G>A": 1}}	\N
7942402	7941119	c.6628G>T/c.8527T>C	{"RYR1": {"c.6628G>T": 1, "c.8527T>C": 1}}	\N
7942403	7941119	c.1553T>C/c.6487C>T	{"RYR1": {"c.1553T>C": 1, "c.6487C>T": 1}}	\N
7942404	7941119	c.5033A>G/c.7060G>A	{"RYR1": {"c.5033A>G": 1, "c.7060G>A": 1}}	\N
7942405	7941119	c.1630G>T/c.10229C>A	{"RYR1": {"c.1630G>T": 1, "c.10229C>A": 1}}	\N
7942406	7941119	c.496G>A/c.6617C>G	{"RYR1": {"c.496G>A": 1, "c.6617C>G": 1}}	\N
7942407	7941119	c.7317G>C/c.7373G>A	{"RYR1": {"c.7317G>C": 1, "c.7373G>A": 1}}	\N
7942408	7941119	c.7879G>C/c.12413T>C	{"RYR1": {"c.7879G>C": 1, "c.12413T>C": 1}}	\N
7942409	7941119	c.1615T>C/c.8527T>C	{"RYR1": {"c.1615T>C": 1, "c.8527T>C": 1}}	\N
7942410	7941119	c.7199A>G/c.7304G>A	{"RYR1": {"c.7199A>G": 1, "c.7304G>A": 1}}	\N
7942411	7941119	c.2050G>C/c.6617C>G	{"RYR1": {"c.2050G>C": 1, "c.6617C>G": 1}}	\N
7942412	7941119	c.742G>C/c.11953T>C	{"RYR1": {"c.742G>C": 1, "c.11953T>C": 1}}	\N
7942413	7941119	c.7063C>T/c.11518G>A	{"RYR1": {"c.7063C>T": 1, "c.11518G>A": 1}}	\N
7942414	7941119	c.1630G>T/c.14558C>T	{"RYR1": {"c.1630G>T": 1, "c.14558C>T": 1}}	\N
7942415	7941119	c.1834G>C/c.12700G>T	{"RYR1": {"c.1834G>C": 1, "c.12700G>T": 1}}	\N
7942416	7941119	c.6488G>T/c.12115A>T	{"RYR1": {"c.6488G>T": 1, "c.12115A>T": 1}}	\N
7942417	7941119	c.7304G>T/c.12398A>G	{"RYR1": {"c.7304G>T": 1, "c.12398A>G": 1}}	\N
7942418	7941119	c.7354C>T/c.8600T>A	{"RYR1": {"c.7354C>T": 1, "c.8600T>A": 1}}	\N
7942419	7941119	c.1202G>T/c.12064A>G	{"RYR1": {"c.1202G>T": 1, "c.12064A>G": 1}}	\N
7942420	7941119	c.6617C>T/c.8290G>A	{"RYR1": {"c.6617C>T": 1, "c.8290G>A": 1}}	\N
7942421	7941119	c.7317G>C/c.7373G>T	{"RYR1": {"c.7317G>C": 1, "c.7373G>T": 1}}	\N
7942422	7941119	c.9310G>A/c.12398A>G	{"RYR1": {"c.9310G>A": 1, "c.12398A>G": 1}}	\N
7942423	7941119	c.7310C>T/c.8638G>A	{"RYR1": {"c.7310C>T": 1, "c.8638G>A": 1}}	\N
7942424	7941119	c.7358T>C/c.8189A>G	{"RYR1": {"c.7358T>C": 1, "c.8189A>G": 1}}	\N
7942425	7941119	c.13673G>A/c.14497C>T	{"RYR1": {"c.13673G>A": 1, "c.14497C>T": 1}}	\N
7942426	7941119	c.178G>T/c.14539G>C	{"RYR1": {"c.178G>T": 1, "c.14539G>C": 1}}	\N
7942427	7941119	c.14210G>A/c.14818G>A	{"RYR1": {"c.14210G>A": 1, "c.14818G>A": 1}}	\N
7942428	7941119	c.7310C>T/c.9850T>A	{"RYR1": {"c.7310C>T": 1, "c.9850T>A": 1}}	\N
7942429	7941119	c.1654C>T/c.13672C>T	{"RYR1": {"c.1654C>T": 1, "c.13672C>T": 1}}	\N
7942430	7941119	c.6304G>C/c.14477C>T	{"RYR1": {"c.6304G>C": 1, "c.14477C>T": 1}}	\N
7942431	7941119	c.7018T>C/c.11315G>A	{"RYR1": {"c.7018T>C": 1, "c.11315G>A": 1}}	\N
7942432	7941119	c.7043A>G/c.10237A>T	{"RYR1": {"c.7043A>G": 1, "c.10237A>T": 1}}	\N
7942433	7941119	c.6349G>C/c.12121C>T	{"RYR1": {"c.6349G>C": 1, "c.12121C>T": 1}}	\N
7942434	7941119	c.6304G>C/c.11969G>T	{"RYR1": {"c.6304G>C": 1, "c.11969G>T": 1}}	\N
7942435	7941119	c.5183C>T/c.7771C>T	{"RYR1": {"c.5183C>T": 1, "c.7771C>T": 1}}	\N
7942436	7941119	c.7090T>G/c.14581C>T	{"RYR1": {"c.7090T>G": 1, "c.14581C>T": 1}}	\N
7942437	7941119	c.4400A>G/c.14918C>T	{"RYR1": {"c.4400A>G": 1, "c.14918C>T": 1}}	\N
7942438	7941119	c.1615T>C/c.11126C>T	{"RYR1": {"c.1615T>C": 1, "c.11126C>T": 1}}	\N
7942439	7941119	c.7007G>A/c.14186A>C	{"RYR1": {"c.7007G>A": 1, "c.14186A>C": 1}}	\N
7942440	7941119	c.5183C>T/c.7771C>G	{"RYR1": {"c.5183C>T": 1, "c.7771C>G": 1}}	\N
7942441	7941119	c.6387C>G/c.11120G>T	{"RYR1": {"c.6387C>G": 1, "c.11120G>T": 1}}	\N
7942442	7941119	c.677T>A/c.7063C>T	{"RYR1": {"c.677T>A": 1, "c.7063C>T": 1}}	\N
7942443	7941119	c.7372C>T/c.9152G>A	{"RYR1": {"c.7372C>T": 1, "c.9152G>A": 1}}	\N
7942444	7941119	c.947G>T/c.6488G>T	{"RYR1": {"c.947G>T": 1, "c.6488G>T": 1}}	\N
7942445	7941119	c.4400A>G/c.7879G>C	{"RYR1": {"c.4400A>G": 1, "c.7879G>C": 1}}	\N
7942446	7941119	c.97A>G/c.14639T>C	{"RYR1": {"c.97A>G": 1, "c.14639T>C": 1}}	\N
7942447	7941119	c.97A>G/c.14968A>G	{"RYR1": {"c.97A>G": 1, "c.14968A>G": 1}}	\N
7942448	7941119	c.3418C>T/c.7522C>T	{"RYR1": {"c.3418C>T": 1, "c.7522C>T": 1}}	\N
7942449	7941119	c.1202G>A/c.7385C>T	{"RYR1": {"c.1202G>A": 1, "c.7385C>T": 1}}	\N
7942450	7941119	c.488G>T/c.6640G>A	{"RYR1": {"c.488G>T": 1, "c.6640G>A": 1}}	\N
7942451	7941119	c.51_53del/c.14627A>G	{"RYR1": {"c.14627A>G": 1, "c.51_53del": 1}}	\N
7942452	7941119	c.488G>A/c.14918C>T	{"RYR1": {"c.488G>A": 1, "c.14918C>T": 1}}	\N
7942453	7941119	c.6037A>C/c.12149C>A	{"RYR1": {"c.6037A>C": 1, "c.12149C>A": 1}}	\N
7942454	7941119	c.7292A>T/c.7879G>C	{"RYR1": {"c.7292A>T": 1, "c.7879G>C": 1}}	\N
7942455	7941119	c.947G>T/c.6488G>C	{"RYR1": {"c.947G>T": 1, "c.6488G>C": 1}}	\N
7942456	7941119	c.7043A>G/c.14818G>A	{"RYR1": {"c.7043A>G": 1, "c.14818G>A": 1}}	\N
7942457	7941119	c.6488G>T/c.13672C>T	{"RYR1": {"c.6488G>T": 1, "c.13672C>T": 1}}	\N
7942458	7941119	c.7291G>A/c.11813G>A	{"RYR1": {"c.7291G>A": 1, "c.11813G>A": 1}}	\N
7942459	7941119	c.14627A>G/c.14968A>G	{"RYR1": {"c.14627A>G": 1, "c.14968A>G": 1}}	\N
7942460	7941119	c.947G>T/c.6488G>A	{"RYR1": {"c.947G>T": 1, "c.6488G>A": 1}}	\N
7942461	7941119	c.1202G>T/c.14449A>T	{"RYR1": {"c.1202G>T": 1, "c.14449A>T": 1}}	\N
7942462	7941119	c.3667G>A/c.5183C>T	{"RYR1": {"c.3667G>A": 1, "c.5183C>T": 1}}	\N
7942463	7941119	c.6628G>T/c.11953T>C	{"RYR1": {"c.6628G>T": 1, "c.11953T>C": 1}}	\N
7942464	7941119	c.178G>T/c.6387C>G	{"RYR1": {"c.178G>T": 1, "c.6387C>G": 1}}	\N
7942465	7941119	c.14186A>C/c.14545G>A	{"RYR1": {"c.14186A>C": 1, "c.14545G>A": 1}}	\N
7942466	7941119	c.2996G>A/c.11315G>A	{"RYR1": {"c.2996G>A": 1, "c.11315G>A": 1}}	\N
7942467	7941119	c.6838G>A/c.14825G>T	{"RYR1": {"c.6838G>A": 1, "c.14825G>T": 1}}	\N
7942468	7941119	c.7282G>A/c.14387A>G	{"RYR1": {"c.7282G>A": 1, "c.14387A>G": 1}}	\N
7942469	7941119	c.488G>T/c.14186A>C	{"RYR1": {"c.488G>T": 1, "c.14186A>C": 1}}	\N
7942470	7941119	c.1654C>T/c.14814C>G	{"RYR1": {"c.1654C>T": 1, "c.14814C>G": 1}}	\N
7942471	7941119	c.5341T>C/c.7007G>A	{"RYR1": {"c.5341T>C": 1, "c.7007G>A": 1}}	\N
7942472	7941119	c.14539G>C/c.14817C>A	{"RYR1": {"c.14539G>C": 1, "c.14817C>A": 1}}	\N
7942473	7941119	c.7360C>T/c.8527T>C	{"RYR1": {"c.7360C>T": 1, "c.8527T>C": 1}}	\N
7942474	7941119	c.7522C>T/c.11126C>T	{"RYR1": {"c.7522C>T": 1, "c.11126C>T": 1}}	\N
7942475	7941119	c.1630G>T/c.14509C>G	{"RYR1": {"c.1630G>T": 1, "c.14509C>G": 1}}	\N
7942476	7941119	c.1201C>T/c.15060G>C	{"RYR1": {"c.1201C>T": 1, "c.15060G>C": 1}}	\N
7942477	7941119	c.463C>A/c.6037A>C	{"RYR1": {"c.463C>A": 1, "c.6037A>C": 1}}	\N
7942478	7941119	c.6387C>G/c.12383C>T	{"RYR1": {"c.6387C>G": 1, "c.12383C>T": 1}}	\N
7942479	7941119	c.7036G>A/c.9868G>A	{"RYR1": {"c.7036G>A": 1, "c.9868G>A": 1}}	\N
7942480	7941119	c.5183C>T/c.13934G>A	{"RYR1": {"c.5183C>T": 1, "c.13934G>A": 1}}	\N
7942481	7941119	c.8638G>A/c.12149C>A	{"RYR1": {"c.8638G>A": 1, "c.12149C>A": 1}}	\N
7942482	7941119	c.992_994dup/c.7123G>A	{"RYR1": {"c.7123G>A": 1, "c.992_994dup": 1}}	\N
7942483	7941119	c.14458G>A/c.14497C>T	{"RYR1": {"c.14458G>A": 1, "c.14497C>T": 1}}	\N
7942484	7941119	c.119G>C/c.14803G>A	{"RYR1": {"c.119G>C": 1, "c.14803G>A": 1}}	\N
7942485	7941119	c.533A>C/c.7523G>A	{"RYR1": {"c.533A>C": 1, "c.7523G>A": 1}}	\N
7942486	7941119	c.1630G>T/c.12064A>G	{"RYR1": {"c.1630G>T": 1, "c.12064A>G": 1}}	\N
7942487	7941119	c.1834G>C/c.7060G>A	{"RYR1": {"c.1834G>C": 1, "c.7060G>A": 1}}	\N
7942488	7941119	c.2537C>T/c.7123G>A	{"RYR1": {"c.2537C>T": 1, "c.7123G>A": 1}}	\N
7942489	7941119	c.6488G>A/c.9649T>C	{"RYR1": {"c.6488G>A": 1, "c.9649T>C": 1}}	\N
7942490	7941119	c.14477C>T/c.14639T>C	{"RYR1": {"c.14477C>T": 1, "c.14639T>C": 1}}	\N
7942491	7941119	c.533A>G/c.15060G>C	{"RYR1": {"c.533A>G": 1, "c.15060G>C": 1}}	\N
7942492	7941119	c.9758T>C/c.14497C>T	{"RYR1": {"c.9758T>C": 1, "c.14497C>T": 1}}	\N
7942493	7941119	c.8654C>G/c.11969G>T	{"RYR1": {"c.8654C>G": 1, "c.11969G>T": 1}}	\N
7942494	7941119	c.7063C>T/c.12533G>T	{"RYR1": {"c.7063C>T": 1, "c.12533G>T": 1}}	\N
7942495	7941119	c.7522C>G/c.12149C>A	{"RYR1": {"c.7522C>G": 1, "c.12149C>A": 1}}	\N
7942496	7941119	c.130C>T/c.11947C>T	{"RYR1": {"c.130C>T": 1, "c.11947C>T": 1}}	\N
7942497	7941119	c.12115A>T/c.14545G>A	{"RYR1": {"c.12115A>T": 1, "c.14545G>A": 1}}	\N
7942498	7941119	c.7060G>A/c.14678G>A	{"RYR1": {"c.7060G>A": 1, "c.14678G>A": 1}}	\N
7942499	7941119	c.6304G>C/c.7124G>C	{"RYR1": {"c.6304G>C": 1, "c.7124G>C": 1}}	\N
7942500	7941119	c.7018T>C/c.14627A>G	{"RYR1": {"c.7018T>C": 1, "c.14627A>G": 1}}	\N
7942501	7941119	c.1840C>T/c.9652G>A	{"RYR1": {"c.1840C>T": 1, "c.9652G>A": 1}}	\N
7942502	7941119	c.7360C>T/c.9758T>C	{"RYR1": {"c.7360C>T": 1, "c.9758T>C": 1}}	\N
7942503	7941119	c.1841G>T/c.8638G>A	{"RYR1": {"c.1841G>T": 1, "c.8638G>A": 1}}	\N
7942504	7941119	c.8026C>T/c.13918A>G	{"RYR1": {"c.8026C>T": 1, "c.13918A>G": 1}}	\N
7942505	7941119	c.1202G>T/c.14825G>T	{"RYR1": {"c.1202G>T": 1, "c.14825G>T": 1}}	\N
7942506	7941119	c.5132A>G/c.7084G>A	{"RYR1": {"c.5132A>G": 1, "c.7084G>A": 1}}	\N
7942507	7941119	c.5024T>C/c.9310G>A	{"RYR1": {"c.5024T>C": 1, "c.9310G>A": 1}}	\N
7942508	7941119	c.7304G>T/c.12242C>T	{"RYR1": {"c.7304G>T": 1, "c.12242C>T": 1}}	\N
7942509	7941119	c.1202G>A/c.10750G>C	{"RYR1": {"c.1202G>A": 1, "c.10750G>C": 1}}	\N
7942510	7941119	c.7018T>C/c.14497C>T	{"RYR1": {"c.7018T>C": 1, "c.14497C>T": 1}}	\N
7942511	7941119	c.7073T>A/c.7373G>A	{"RYR1": {"c.7073T>A": 1, "c.7373G>A": 1}}	\N
7942512	7941119	c.992_994dup/c.1615T>G	{"RYR1": {"c.1615T>G": 1, "c.992_994dup": 1}}	\N
7942513	7941119	c.992_994dup/c.1615T>C	{"RYR1": {"c.1615T>C": 1, "c.992_994dup": 1}}	\N
7942514	7941119	c.6478G>A/c.6502G>A	{"RYR1": {"c.6478G>A": 1, "c.6502G>A": 1}}	\N
7942515	7941119	c.1453A>G/c.1565A>G	{"RYR1": {"c.1453A>G": 1, "c.1565A>G": 1}}	\N
7942516	7941119	c.992_994dup/c.1841G>T	{"RYR1": {"c.1841G>T": 1, "c.992_994dup": 1}}	\N
7942517	7941119	c.9310G>A/c.9797T>C	{"RYR1": {"c.9310G>A": 1, "c.9797T>C": 1}}	\N
7942518	7941119	c.1453A>G/c.1565A>C	{"RYR1": {"c.1453A>G": 1, "c.1565A>C": 1}}	\N
7942519	7941119	c.1654C>T/c.9649T>C	{"RYR1": {"c.1654C>T": 1, "c.9649T>C": 1}}	\N
7942520	7941119	c.103T>C/c.12689T>G	{"RYR1": {"c.103T>C": 1, "c.12689T>G": 1}}	\N
7942521	7941119	c.1589G>A/c.8290G>A	{"RYR1": {"c.1589G>A": 1, "c.8290G>A": 1}}	\N
7942522	7941119	c.533A>G/c.15059G>C	{"RYR1": {"c.533A>G": 1, "c.15059G>C": 1}}	\N
7942523	7941119	c.6617C>G/c.14678G>A	{"RYR1": {"c.6617C>G": 1, "c.14678G>A": 1}}	\N
7942524	7941119	c.1100G>T/c.9310G>A	{"RYR1": {"c.1100G>T": 1, "c.9310G>A": 1}}	\N
7942525	7941119	c.6488G>C/c.11958C>G	{"RYR1": {"c.6488G>C": 1, "c.11958C>G": 1}}	\N
7942526	7941119	c.5183C>T/c.14126C>T	{"RYR1": {"c.5183C>T": 1, "c.14126C>T": 1}}	\N
7942527	7941119	c.12383C>T/c.14477C>T	{"RYR1": {"c.12383C>T": 1, "c.14477C>T": 1}}	\N
7942528	7941119	c.7291G>A/c.7292A>T	{"RYR1": {"c.7291G>A": 1, "c.7292A>T": 1}}	\N
7942529	7941119	c.1201C>T/c.15059G>C	{"RYR1": {"c.1201C>T": 1, "c.15059G>C": 1}}	\N
7942530	7941119	c.1589G>A/c.7385C>T	{"RYR1": {"c.1589G>A": 1, "c.7385C>T": 1}}	\N
7942531	7941119	c.4400A>G/c.7300G>A	{"RYR1": {"c.4400A>G": 1, "c.7300G>A": 1}}	\N
7942532	7941119	c.6488G>C/c.9649T>C	{"RYR1": {"c.6488G>C": 1, "c.9649T>C": 1}}	\N
7942533	7941119	c.7373G>T/c.8654C>G	{"RYR1": {"c.7373G>T": 1, "c.8654C>G": 1}}	\N
7942534	7941119	c.6304G>C/c.6387C>G	{"RYR1": {"c.6304G>C": 1, "c.6387C>G": 1}}	\N
7942535	7941119	c.7373G>T/c.10042C>T	{"RYR1": {"c.7373G>T": 1, "c.10042C>T": 1}}	\N
7942536	7941119	c.487C>T/c.12115A>T	{"RYR1": {"c.487C>T": 1, "c.12115A>T": 1}}	\N
7942537	7941119	c.982C>T/c.14458G>T	{"RYR1": {"c.982C>T": 1, "c.14458G>T": 1}}	\N
7942538	7941119	c.103T>C/c.12115A>T	{"RYR1": {"c.103T>C": 1, "c.12115A>T": 1}}	\N
7942539	7941119	c.7042_7044delGAG/c.10556C>T	{"RYR1": {"c.10556C>T": 1, "c.7042_7044delGAG": 1}}	\N
7942540	7941119	c.5183C>T/c.7099G>A	{"RYR1": {"c.5183C>T": 1, "c.7099G>A": 1}}	\N
7942541	7941119	c.7036G>A/c.14509C>G	{"RYR1": {"c.7036G>A": 1, "c.14509C>G": 1}}	\N
7942542	7941119	c.7036G>A/c.9652G>A	{"RYR1": {"c.7036G>A": 1, "c.9652G>A": 1}}	\N
7942543	7941119	c.2996G>A/c.14627A>G	{"RYR1": {"c.2996G>A": 1, "c.14627A>G": 1}}	\N
7942544	7941119	c.7307G>A/c.14803G>A	{"RYR1": {"c.7307G>A": 1, "c.14803G>A": 1}}	\N
7942545	7941119	c.7073T>A/c.7373G>T	{"RYR1": {"c.7073T>A": 1, "c.7373G>T": 1}}	\N
7942546	7941119	c.982C>T/c.14458G>A	{"RYR1": {"c.982C>T": 1, "c.14458G>A": 1}}	\N
7942547	7941119	c.7373G>T/c.8527T>C	{"RYR1": {"c.7373G>T": 1, "c.8527T>C": 1}}	\N
7942548	7941119	c.497A>G/c.14512C>G	{"RYR1": {"c.497A>G": 1, "c.14512C>G": 1}}	\N
7942549	7941119	c.7291G>T/c.12848A>T	{"RYR1": {"c.7291G>T": 1, "c.12848A>T": 1}}	\N
7942550	7941119	c.3166G>A/c.7310C>T	{"RYR1": {"c.3166G>A": 1, "c.7310C>T": 1}}	\N
7942551	7941119	c.7879G>C/c.10891G>T	{"RYR1": {"c.7879G>C": 1, "c.10891G>T": 1}}	\N
7942552	7941119	c.1841G>T/c.2537C>T	{"RYR1": {"c.1841G>T": 1, "c.2537C>T": 1}}	\N
7942553	7941119	c.1201C>T/c.12848A>T	{"RYR1": {"c.1201C>T": 1, "c.12848A>T": 1}}	\N
7942554	7941119	c.6037A>C/c.6387C>G	{"RYR1": {"c.6037A>C": 1, "c.6387C>G": 1}}	\N
7942555	7941119	c.6488G>A/c.11958C>G	{"RYR1": {"c.6488G>A": 1, "c.11958C>G": 1}}	\N
7942556	7941119	c.14497C>T/c.14693T>C	{"RYR1": {"c.14497C>T": 1, "c.14693T>C": 1}}	\N
7942557	7941119	c.6838G>A/c.11126C>T	{"RYR1": {"c.6838G>A": 1, "c.11126C>T": 1}}	\N
7942558	7941119	c.7048G>A/c.14680G>A	{"RYR1": {"c.7048G>A": 1, "c.14680G>A": 1}}	\N
7942559	7941119	c.533A>G/c.12848A>T	{"RYR1": {"c.533A>G": 1, "c.12848A>T": 1}}	\N
7942560	7941119	c.1654C>T/c.8188G>C	{"RYR1": {"c.1654C>T": 1, "c.8188G>C": 1}}	\N
7942561	7941119	c.1202G>A/c.14558C>T	{"RYR1": {"c.1202G>A": 1, "c.14558C>T": 1}}	\N
7942562	7941119	c.11416G>A/c.14209C>T	{"RYR1": {"c.11416G>A": 1, "c.14209C>T": 1}}	\N
7942563	7941119	c.6612C>G/c.8926C>T	{"RYR1": {"c.6612C>G": 1, "c.8926C>T": 1}}	\N
7942564	7941119	c.7522C>T/c.10042C>T	{"RYR1": {"c.7522C>T": 1, "c.10042C>T": 1}}	\N
7942565	7941119	c.2996G>A/c.14497C>T	{"RYR1": {"c.2996G>A": 1, "c.14497C>T": 1}}	\N
7942566	7941119	c.1840C>T/c.9676G>C	{"RYR1": {"c.1840C>T": 1, "c.9676G>C": 1}}	\N
7942567	7941119	c.1589G>A/c.2537C>T	{"RYR1": {"c.1589G>A": 1, "c.2537C>T": 1}}	\N
7942568	7941119	c.7373G>A/c.13934G>A	{"RYR1": {"c.7373G>A": 1, "c.13934G>A": 1}}	\N
7942569	7941119	c.7043A>G/c.11132C>T	{"RYR1": {"c.7043A>G": 1, "c.11132C>T": 1}}	\N
7942570	7941119	c.3095G>A/c.7043A>G	{"RYR1": {"c.3095G>A": 1, "c.7043A>G": 1}}	\N
7942571	7941119	c.10891G>T/c.14477C>T	{"RYR1": {"c.10891G>T": 1, "c.14477C>T": 1}}	\N
7942572	7941119	c.7090T>G/c.11086G>C	{"RYR1": {"c.7090T>G": 1, "c.11086G>C": 1}}	\N
7942573	7941119	c.7522C>T/c.7760A>G	{"RYR1": {"c.7522C>T": 1, "c.7760A>G": 1}}	\N
7942574	7941119	c.7123G>A/c.14270G>A	{"RYR1": {"c.7123G>A": 1, "c.14270G>A": 1}}	\N
7942575	7941119	c.12413T>C/c.14627A>G	{"RYR1": {"c.12413T>C": 1, "c.14627A>G": 1}}	\N
7942576	7941119	c.1565A>G/c.8188G>C	{"RYR1": {"c.1565A>G": 1, "c.8188G>C": 1}}	\N
7942577	7941119	c.1630G>T/c.9868G>A	{"RYR1": {"c.1630G>T": 1, "c.9868G>A": 1}}	\N
7942578	7941119	c.7310C>T/c.9268G>A	{"RYR1": {"c.7310C>T": 1, "c.9268G>A": 1}}	\N
7942579	7941119	c.7036G>A/c.12064A>G	{"RYR1": {"c.7036G>A": 1, "c.12064A>G": 1}}	\N
7942580	7941119	c.7007G>A/c.8926C>T	{"RYR1": {"c.7007G>A": 1, "c.8926C>T": 1}}	\N
7942581	7941119	c.103T>C/c.4747C>T	{"RYR1": {"c.103T>C": 1, "c.4747C>T": 1}}	\N
7942582	7941119	c.8729C>T/c.14209C>T	{"RYR1": {"c.8729C>T": 1, "c.14209C>T": 1}}	\N
7942583	7941119	c.7032G>C/c.7282G>A	{"RYR1": {"c.7032G>C": 1, "c.7282G>A": 1}}	\N
7942584	7941119	c.6387C>G/c.14458G>A	{"RYR1": {"c.6387C>G": 1, "c.14458G>A": 1}}	\N
7942585	7941119	c.3166G>A/c.12700G>T	{"RYR1": {"c.3166G>A": 1, "c.12700G>T": 1}}	\N
7942586	7941119	c.493G>A/c.7360C>T	{"RYR1": {"c.493G>A": 1, "c.7360C>T": 1}}	\N
7942587	7941119	c.5440A>G/c.7282G>A	{"RYR1": {"c.5440A>G": 1, "c.7282G>A": 1}}	\N
7942588	7941119	c.1654C>T/c.4747C>T	{"RYR1": {"c.1654C>T": 1, "c.4747C>T": 1}}	\N
7942589	7941119	c.463C>A/c.3527C>T	{"RYR1": {"c.463C>A": 1, "c.3527C>T": 1}}	\N
7942590	7941119	c.7042_7044delGAG/c.14449A>T	{"RYR1": {"c.14449A>T": 1, "c.7042_7044delGAG": 1}}	\N
7942591	7941119	c.4747C>T/c.7300G>A	{"RYR1": {"c.4747C>T": 1, "c.7300G>A": 1}}	\N
7942592	7941119	c.7354C>T/c.9152G>A	{"RYR1": {"c.7354C>T": 1, "c.9152G>A": 1}}	\N
7942593	7941119	c.7063C>T/c.10229C>A	{"RYR1": {"c.7063C>T": 1, "c.10229C>A": 1}}	\N
7942594	7941119	c.3166G>A/c.12700G>C	{"RYR1": {"c.3166G>A": 1, "c.12700G>C": 1}}	\N
7942595	7941119	c.7304G>A/c.14002C>T	{"RYR1": {"c.7304G>A": 1, "c.14002C>T": 1}}	\N
7942596	7941119	c.488G>T/c.652G>A	{"RYR1": {"c.488G>T": 1, "c.652G>A": 1}}	\N
7942597	7941119	c.7292A>T/c.14918C>T	{"RYR1": {"c.7292A>T": 1, "c.14918C>T": 1}}	\N
7942598	7941119	c.7035C>A/c.9268G>A	{"RYR1": {"c.7035C>A": 1, "c.9268G>A": 1}}	\N
7942599	7941119	c.12848A>T/c.14497C>T	{"RYR1": {"c.12848A>T": 1, "c.14497C>T": 1}}	\N
7942600	7941119	c.7043A>G/c.14422_14423delinsAA	{"RYR1": {"c.7043A>G": 1, "c.14422_14423delinsAA": 1}}	\N
7942601	7941119	c.6387C>G/c.14458G>T	{"RYR1": {"c.6387C>G": 1, "c.14458G>T": 1}}	\N
7942602	7941119	c.1589G>A/c.14678G>A	{"RYR1": {"c.1589G>A": 1, "c.14678G>A": 1}}	\N
7942603	7941119	c.7036G>A/c.14449A>T	{"RYR1": {"c.7036G>A": 1, "c.14449A>T": 1}}	\N
7942604	7941119	c.6742C>T/c.7879G>C	{"RYR1": {"c.6742C>T": 1, "c.7879G>C": 1}}	\N
7942605	7941119	c.5132A>G/c.7060G>A	{"RYR1": {"c.5132A>G": 1, "c.7060G>A": 1}}	\N
7942606	7941119	c.5033A>G/c.7084G>A	{"RYR1": {"c.5033A>G": 1, "c.7084G>A": 1}}	\N
7942607	7941119	c.1201C>A/c.8026C>T	{"RYR1": {"c.1201C>A": 1, "c.8026C>T": 1}}	\N
7942608	7941119	c.178G>A/c.7358T>C	{"RYR1": {"c.178G>A": 1, "c.7358T>C": 1}}	\N
7942609	7941119	c.7361G>A/c.11813G>A	{"RYR1": {"c.7361G>A": 1, "c.11813G>A": 1}}	\N
7942610	7941119	c.7317G>C/c.7361G>A	{"RYR1": {"c.7317G>C": 1, "c.7361G>A": 1}}	\N
7942611	7941119	c.9649T>C/c.14803G>A	{"RYR1": {"c.9649T>C": 1, "c.14803G>A": 1}}	\N
7942612	7941119	c.6037A>C/c.7063C>T	{"RYR1": {"c.6037A>C": 1, "c.7063C>T": 1}}	\N
7942613	7941119	c.7090T>G/c.11132C>T	{"RYR1": {"c.7090T>G": 1, "c.11132C>T": 1}}	\N
7942614	7941119	c.7282G>A/c.13760C>T	{"RYR1": {"c.7282G>A": 1, "c.13760C>T": 1}}	\N
7942615	7941119	c.6599C>T/c.9310G>A	{"RYR1": {"c.6599C>T": 1, "c.9310G>A": 1}}	\N
7942616	7941119	c.488G>A/c.529C>T	{"RYR1": {"c.488G>A": 1, "c.529C>T": 1}}	\N
7942617	7941119	c.1201C>A/c.1589G>A	{"RYR1": {"c.1201C>A": 1, "c.1589G>A": 1}}	\N
7942618	7941119	c.2537C>T/c.7879G>C	{"RYR1": {"c.2537C>T": 1, "c.7879G>C": 1}}	\N
7942619	7941119	c.528G>T/c.7291G>T	{"RYR1": {"c.528G>T": 1, "c.7291G>T": 1}}	\N
7942620	7941119	c.12700G>T/c.14126C>T	{"RYR1": {"c.12700G>T": 1, "c.14126C>T": 1}}	\N
7942621	7941119	c.1615T>G/c.8527T>C	{"RYR1": {"c.1615T>G": 1, "c.8527T>C": 1}}	\N
7942622	7941119	c.488G>T/c.14471T>C	{"RYR1": {"c.488G>T": 1, "c.14471T>C": 1}}	\N
7942623	7941119	c.5183C>T/c.7085A>G	{"RYR1": {"c.5183C>T": 1, "c.7085A>G": 1}}	\N
7942624	7941119	c.533A>G/c.7787C>T	{"RYR1": {"c.533A>G": 1, "c.7787C>T": 1}}	\N
7942625	7941119	c.1202G>T/c.8518C>T	{"RYR1": {"c.1202G>T": 1, "c.8518C>T": 1}}	\N
7942626	7941119	c.7879G>C/c.10237A>T	{"RYR1": {"c.7879G>C": 1, "c.10237A>T": 1}}	\N
7942627	7941119	c.528G>T/c.7291G>A	{"RYR1": {"c.528G>T": 1, "c.7291G>A": 1}}	\N
7942628	7941119	c.1202G>T/c.9868G>A	{"RYR1": {"c.1202G>T": 1, "c.9868G>A": 1}}	\N
7942629	7941119	c.6387C>G/c.12689T>G	{"RYR1": {"c.6387C>G": 1, "c.12689T>G": 1}}	\N
7942630	7941119	c.9310G>A/c.12242C>T	{"RYR1": {"c.9310G>A": 1, "c.12242C>T": 1}}	\N
7942631	7941119	c.6502G>A/c.14270G>A	{"RYR1": {"c.6502G>A": 1, "c.14270G>A": 1}}	\N
7942632	7941119	c.6502G>A/c.11723A>T	{"RYR1": {"c.6502G>A": 1, "c.11723A>T": 1}}	\N
7942633	7941119	c.7073T>A/c.7361G>A	{"RYR1": {"c.7073T>A": 1, "c.7361G>A": 1}}	\N
7942634	7941119	c.8527T>C/c.14918C>T	{"RYR1": {"c.8527T>C": 1, "c.14918C>T": 1}}	\N
7942635	7941119	c.680A>T/c.14477C>T	{"RYR1": {"c.680A>T": 1, "c.14477C>T": 1}}	\N
7942636	7941119	c.3418C>T/c.7354C>T	{"RYR1": {"c.3418C>T": 1, "c.7354C>T": 1}}	\N
7942637	7941119	c.7043A>G/c.11086G>C	{"RYR1": {"c.7043A>G": 1, "c.11086G>C": 1}}	\N
7942638	7941119	c.1630G>T/c.7385C>T	{"RYR1": {"c.1630G>T": 1, "c.7385C>T": 1}}	\N
7942639	7941119	c.7035C>A/c.7771C>G	{"RYR1": {"c.7035C>A": 1, "c.7771C>G": 1}}	\N
7942640	7941119	c.3127C>T/c.7310C>T	{"RYR1": {"c.3127C>T": 1, "c.7310C>T": 1}}	\N
7942641	7941119	c.7042_7044delGAG/c.14509C>G	{"RYR1": {"c.14509C>G": 1, "c.7042_7044delGAG": 1}}	\N
7942642	7941119	c.7358T>C/c.11086G>C	{"RYR1": {"c.7358T>C": 1, "c.11086G>C": 1}}	\N
7942643	7941119	c.7523G>A/c.14680G>A	{"RYR1": {"c.7523G>A": 1, "c.14680G>A": 1}}	\N
7942644	7941119	c.5183C>T/c.10042C>T	{"RYR1": {"c.5183C>T": 1, "c.10042C>T": 1}}	\N
7942645	7941119	c.7124G>C/c.9652G>A	{"RYR1": {"c.7124G>C": 1, "c.9652G>A": 1}}	\N
7942646	7941119	c.1565A>C/c.8188G>C	{"RYR1": {"c.1565A>C": 1, "c.8188G>C": 1}}	\N
7942647	7941119	c.496G>A/c.7354C>T	{"RYR1": {"c.496G>A": 1, "c.7354C>T": 1}}	\N
7942648	7941119	c.1565A>C/c.6304G>C	{"RYR1": {"c.1565A>C": 1, "c.6304G>C": 1}}	\N
7942649	7941119	c.103T>C/c.8527T>C	{"RYR1": {"c.103T>C": 1, "c.8527T>C": 1}}	\N
7942650	7941119	c.7036G>A/c.10229C>A	{"RYR1": {"c.7036G>A": 1, "c.10229C>A": 1}}	\N
7942651	7941119	c.3527C>T/c.14497C>T	{"RYR1": {"c.3527C>T": 1, "c.14497C>T": 1}}	\N
7942652	7941119	c.130C>T/c.6544A>T	{"RYR1": {"c.130C>T": 1, "c.6544A>T": 1}}	\N
7942653	7941119	c.97A>G/c.7292A>T	{"RYR1": {"c.97A>G": 1, "c.7292A>T": 1}}	\N
7942654	7941119	c.12700G>C/c.14126C>T	{"RYR1": {"c.12700G>C": 1, "c.14126C>T": 1}}	\N
7942655	7941119	c.5033A>G/c.14210G>A	{"RYR1": {"c.5033A>G": 1, "c.14210G>A": 1}}	\N
7942656	7941119	c.7035C>A/c.7771C>T	{"RYR1": {"c.7035C>A": 1, "c.7771C>T": 1}}	\N
7942657	7941119	c.3127C>T/c.12700G>T	{"RYR1": {"c.3127C>T": 1, "c.12700G>T": 1}}	\N
7942658	7941119	c.2122G>A/c.11315G>A	{"RYR1": {"c.2122G>A": 1, "c.11315G>A": 1}}	\N
7942659	7941119	c.7354C>T/c.11947C>T	{"RYR1": {"c.7354C>T": 1, "c.11947C>T": 1}}	\N
7942660	7941119	c.1024G>A/c.9310G>A	{"RYR1": {"c.1024G>A": 1, "c.9310G>A": 1}}	\N
7942661	7941119	c.625G>A/c.6488G>A	{"RYR1": {"c.625G>A": 1, "c.6488G>A": 1}}	\N
7942662	7941119	c.3127C>T/c.12700G>C	{"RYR1": {"c.3127C>T": 1, "c.12700G>C": 1}}	\N
7942663	7941119	c.4775C>T/c.7007G>A	{"RYR1": {"c.4775C>T": 1, "c.7007G>A": 1}}	\N
7942664	7941119	c.7523G>A/c.12028G>A	{"RYR1": {"c.7523G>A": 1, "c.12028G>A": 1}}	\N
7942665	7941119	c.97A>G/c.8198G>A	{"RYR1": {"c.97A>G": 1, "c.8198G>A": 1}}	\N
7942666	7941119	c.13913G>A/c.14545G>A	{"RYR1": {"c.13913G>A": 1, "c.14545G>A": 1}}	\N
7942667	7941119	c.6838G>A/c.8518C>T	{"RYR1": {"c.6838G>A": 1, "c.8518C>T": 1}}	\N
7942668	7941119	c.742G>A/c.12689T>G	{"RYR1": {"c.742G>A": 1, "c.12689T>G": 1}}	\N
7942669	7941119	c.8026C>T/c.11813G>A	{"RYR1": {"c.8026C>T": 1, "c.11813G>A": 1}}	\N
7942670	7941119	c.38T>G/c.8729C>T	{"RYR1": {"c.38T>G": 1, "c.8729C>T": 1}}	\N
7942671	7941119	c.190T>C/c.1597C>T	{"RYR1": {"c.190T>C": 1, "c.1597C>T": 1}}	\N
7942672	7941119	c.7073T>A/c.7879G>C	{"RYR1": {"c.7073T>A": 1, "c.7879G>C": 1}}	\N
7942673	7941119	c.9310G>A/c.12532G>A	{"RYR1": {"c.9310G>A": 1, "c.12532G>A": 1}}	\N
7942674	7941119	c.625G>A/c.6488G>C	{"RYR1": {"c.625G>A": 1, "c.6488G>C": 1}}	\N
7942675	7941119	c.7060G>A/c.8638G>A	{"RYR1": {"c.7060G>A": 1, "c.8638G>A": 1}}	\N
7942676	7941119	c.1841G>T/c.11723A>T	{"RYR1": {"c.1841G>T": 1, "c.11723A>T": 1}}	\N
7942677	7941119	c.3418C>T/c.14803G>A	{"RYR1": {"c.3418C>T": 1, "c.14803G>A": 1}}	\N
7942678	7941119	c.178G>A/c.7076G>A	{"RYR1": {"c.178G>A": 1, "c.7076G>A": 1}}	\N
7942679	7941119	c.7123G>A/c.9635A>G	{"RYR1": {"c.7123G>A": 1, "c.9635A>G": 1}}	\N
7942680	7941119	c.529C>T/c.3667G>A	{"RYR1": {"c.529C>T": 1, "c.3667G>A": 1}}	\N
7942681	7941119	c.1100G>A/c.6838G>A	{"RYR1": {"c.1100G>A": 1, "c.6838G>A": 1}}	\N
7942682	7941119	c.7043A>G/c.12413T>C	{"RYR1": {"c.7043A>G": 1, "c.12413T>C": 1}}	\N
7942683	7941119	c.625G>A/c.6488G>T	{"RYR1": {"c.625G>A": 1, "c.6488G>T": 1}}	\N
7942684	7941119	c.1553T>C/c.7007G>A	{"RYR1": {"c.1553T>C": 1, "c.7007G>A": 1}}	\N
7942685	7941119	c.8926C>T/c.9310G>A	{"RYR1": {"c.8926C>T": 1, "c.9310G>A": 1}}	\N
7942686	7941119	c.38T>G/c.152C>A	{"RYR1": {"c.38T>G": 1, "c.152C>A": 1}}	\N
7942687	7941119	c.7043A>G/c.8189A>G	{"RYR1": {"c.7043A>G": 1, "c.8189A>G": 1}}	\N
7942688	7941119	c.7073T>A/c.14918C>T	{"RYR1": {"c.7073T>A": 1, "c.14918C>T": 1}}	\N
7942689	7941119	c.487C>T/c.11126C>T	{"RYR1": {"c.487C>T": 1, "c.11126C>T": 1}}	\N
7942690	7941119	c.6617C>G/c.7385C>T	{"RYR1": {"c.6617C>G": 1, "c.7385C>T": 1}}	\N
7942691	7941119	c.38T>G/c.1411C>T	{"RYR1": {"c.38T>G": 1, "c.1411C>T": 1}}	\N
7942692	7941119	c.946C>T/c.6838G>A	{"RYR1": {"c.946C>T": 1, "c.6838G>A": 1}}	\N
7942693	7941119	c.982C>T/c.6478G>A	{"RYR1": {"c.982C>T": 1, "c.6478G>A": 1}}	\N
7942694	7941119	c.11708G>A/c.14509C>G	{"RYR1": {"c.11708G>A": 1, "c.14509C>G": 1}}	\N
7942695	7941119	c.190T>C/c.6349G>C	{"RYR1": {"c.190T>C": 1, "c.6349G>C": 1}}	\N
7942696	7941119	c.6037A>C/c.11969G>T	{"RYR1": {"c.6037A>C": 1, "c.11969G>T": 1}}	\N
7942697	7941119	c.992_994dup/c.1840C>T	{"RYR1": {"c.1840C>T": 1, "c.992_994dup": 1}}	\N
7942698	7941119	c.1597C>T/c.14422_14423delinsAA	{"RYR1": {"c.1597C>T": 1, "c.14422_14423delinsAA": 1}}	\N
7942699	7941119	c.529C>T/c.7032G>C	{"RYR1": {"c.529C>T": 1, "c.7032G>C": 1}}	\N
7942700	7941119	c.493G>A/c.7372C>T	{"RYR1": {"c.493G>A": 1, "c.7372C>T": 1}}	\N
7942701	7941119	c.677T>A/c.6387C>G	{"RYR1": {"c.677T>A": 1, "c.6387C>G": 1}}	\N
7942702	7941119	c.7522C>T/c.13918A>G	{"RYR1": {"c.7522C>T": 1, "c.13918A>G": 1}}	\N
7942703	7941119	c.1615T>C/c.13990T>C	{"RYR1": {"c.1615T>C": 1, "c.13990T>C": 1}}	\N
7942704	7941119	c.251C>T/c.12149C>A	{"RYR1": {"c.251C>T": 1, "c.12149C>A": 1}}	\N
7942705	7941119	c.7310C>T/c.7385C>T	{"RYR1": {"c.7310C>T": 1, "c.7385C>T": 1}}	\N
7942706	7941119	c.742G>C/c.12689T>G	{"RYR1": {"c.742G>C": 1, "c.12689T>G": 1}}	\N
7942707	7941119	c.14422_14423delinsAA/c.14627A>G	{"RYR1": {"c.14627A>G": 1, "c.14422_14423delinsAA": 1}}	\N
7942708	7941119	c.7358T>C/c.12121C>T	{"RYR1": {"c.7358T>C": 1, "c.12121C>T": 1}}	\N
7942709	7941119	c.487C>T/c.7075C>T	{"RYR1": {"c.487C>T": 1, "c.7075C>T": 1}}	\N
7942710	7941119	c.7304G>T/c.9797T>C	{"RYR1": {"c.7304G>T": 1, "c.9797T>C": 1}}	\N
7942711	7941119	c.12413T>C/c.14497C>T	{"RYR1": {"c.12413T>C": 1, "c.14497C>T": 1}}	\N
7942712	7941119	c.38T>G/c.488G>A	{"RYR1": {"c.38T>G": 1, "c.488G>A": 1}}	\N
7942713	7941119	c.2654G>A/c.7043A>G	{"RYR1": {"c.2654G>A": 1, "c.7043A>G": 1}}	\N
7942714	7941119	c.1841G>T/c.6599C>T	{"RYR1": {"c.1841G>T": 1, "c.6599C>T": 1}}	\N
7942715	7941119	c.7291G>T/c.11813G>A	{"RYR1": {"c.7291G>T": 1, "c.11813G>A": 1}}	\N
7942716	7941119	c.5183C>T/c.6037A>C	{"RYR1": {"c.5183C>T": 1, "c.6037A>C": 1}}	\N
7942717	7941119	c.7487C>T/c.14512C>G	{"RYR1": {"c.7487C>T": 1, "c.14512C>G": 1}}	\N
7942718	7941119	c.6304G>C/c.7063C>T	{"RYR1": {"c.6304G>C": 1, "c.7063C>T": 1}}	\N
7942719	7941119	c.982C>T/c.11086G>C	{"RYR1": {"c.982C>T": 1, "c.11086G>C": 1}}	\N
7942720	7941119	c.6488G>C/c.13994_13995delTCinsCT	{"RYR1": {"c.6488G>C": 1, "c.13994_13995delTCinsCT": 1}}	\N
7942721	7941119	c.130C>T/c.2654G>A	{"RYR1": {"c.130C>T": 1, "c.2654G>A": 1}}	\N
7942722	7941119	c.1630G>T/c.14449A>T	{"RYR1": {"c.1630G>T": 1, "c.14449A>T": 1}}	\N
7942723	7941119	c.7124G>C/c.14186A>C	{"RYR1": {"c.7124G>C": 1, "c.14186A>C": 1}}	\N
7942724	7941119	c.6640G>A/c.7304G>A	{"RYR1": {"c.6640G>A": 1, "c.7304G>A": 1}}	\N
7942725	7941119	c.103T>C/c.14814C>G	{"RYR1": {"c.103T>C": 1, "c.14814C>G": 1}}	\N
7942726	7941119	c.6488G>A/c.14814C>G	{"RYR1": {"c.6488G>A": 1, "c.14814C>G": 1}}	\N
7942727	7941119	c.6612C>G/c.14186A>C	{"RYR1": {"c.6612C>G": 1, "c.14186A>C": 1}}	\N
7942728	7941119	c.1565A>C/c.12383C>T	{"RYR1": {"c.1565A>C": 1, "c.12383C>T": 1}}	\N
7942729	7941119	c.97A>G/c.11416G>A	{"RYR1": {"c.97A>G": 1, "c.11416G>A": 1}}	\N
7942730	7941119	c.6742C>T/c.14918C>T	{"RYR1": {"c.6742C>T": 1, "c.14918C>T": 1}}	\N
7942731	7941119	c.1201C>G/c.8026C>T	{"RYR1": {"c.1201C>G": 1, "c.8026C>T": 1}}	\N
7942732	7941119	c.5186T>G/c.14477C>T	{"RYR1": {"c.5186T>G": 1, "c.14477C>T": 1}}	\N
7942733	7941119	c.7035C>A/c.14126C>T	{"RYR1": {"c.7035C>A": 1, "c.14126C>T": 1}}	\N
7942734	7941119	c.7304G>A/c.12398A>G	{"RYR1": {"c.7304G>A": 1, "c.12398A>G": 1}}	\N
7942735	7941119	c.1597C>T/c.12413T>C	{"RYR1": {"c.1597C>T": 1, "c.12413T>C": 1}}	\N
7942736	7941119	c.7073T>A/c.7360C>T	{"RYR1": {"c.7073T>A": 1, "c.7360C>T": 1}}	\N
7942737	7941119	c.7300G>A/c.7879G>A	{"RYR1": {"c.7300G>A": 1, "c.7879G>A": 1}}	\N
7942738	7941119	c.6847A>C/c.7076G>A	{"RYR1": {"c.6847A>C": 1, "c.7076G>A": 1}}	\N
7942739	7941119	c.1021G>C/c.9268G>A	{"RYR1": {"c.1021G>C": 1, "c.9268G>A": 1}}	\N
7942740	7941119	c.7048G>A/c.8926C>T	{"RYR1": {"c.7048G>A": 1, "c.8926C>T": 1}}	\N
7942741	7941119	c.97A>G/c.13994_13995delTCinsCT	{"RYR1": {"c.97A>G": 1, "c.13994_13995delTCinsCT": 1}}	\N
7942742	7941119	c.7042_7044delGAG/c.9868G>A	{"RYR1": {"c.9868G>A": 1, "c.7042_7044delGAG": 1}}	\N
7942743	7941119	c.7199A>G/c.14477C>T	{"RYR1": {"c.7199A>G": 1, "c.14477C>T": 1}}	\N
7942744	7941119	c.529C>T/c.10891G>T	{"RYR1": {"c.529C>T": 1, "c.10891G>T": 1}}	\N
7942745	7941119	c.6488G>A/c.13672C>T	{"RYR1": {"c.6488G>A": 1, "c.13672C>T": 1}}	\N
7942746	7941119	c.1202G>T/c.7385C>T	{"RYR1": {"c.1202G>T": 1, "c.7385C>T": 1}}	\N
7942747	7941119	c.1840C>T/c.14968A>G	{"RYR1": {"c.1840C>T": 1, "c.14968A>G": 1}}	\N
7942748	7941119	c.533A>G/c.7317G>C	{"RYR1": {"c.533A>G": 1, "c.7317G>C": 1}}	\N
7942749	7941119	c.7310C>T/c.14524G>A	{"RYR1": {"c.7310C>T": 1, "c.14524G>A": 1}}	\N
7942750	7941119	c.13505A>G/c.14627A>G	{"RYR1": {"c.13505A>G": 1, "c.14627A>G": 1}}	\N
7942751	7941119	c.130C>T/c.9848G>A	{"RYR1": {"c.130C>T": 1, "c.9848G>A": 1}}	\N
7942752	7941119	c.7778G>A/c.14539G>C	{"RYR1": {"c.7778G>A": 1, "c.14539G>C": 1}}	\N
7942753	7941119	c.1100G>A/c.1630G>T	{"RYR1": {"c.1100G>A": 1, "c.1630G>T": 1}}	\N
7942754	7941119	c.7042_7044delGAG/c.10229C>A	{"RYR1": {"c.10229C>A": 1, "c.7042_7044delGAG": 1}}	\N
7942755	7941119	c.14458G>A/c.14627A>G	{"RYR1": {"c.14458G>A": 1, "c.14627A>G": 1}}	\N
7942756	7941119	c.12553G>A/c.14210G>A	{"RYR1": {"c.12553G>A": 1, "c.14210G>A": 1}}	\N
7942757	7941119	c.7032G>C/c.7076G>A	{"RYR1": {"c.7032G>C": 1, "c.7076G>A": 1}}	\N
7942758	7941119	c.1201C>G/c.14512C>G	{"RYR1": {"c.1201C>G": 1, "c.14512C>G": 1}}	\N
7942759	7941119	c.10252A>G/c.14209C>T	{"RYR1": {"c.10252A>G": 1, "c.14209C>T": 1}}	\N
7942760	7941119	c.2654G>A/c.11708G>A	{"RYR1": {"c.2654G>A": 1, "c.11708G>A": 1}}	\N
7942761	7941119	c.130C>T/c.7210G>A	{"RYR1": {"c.130C>T": 1, "c.7210G>A": 1}}	\N
7942762	7941119	c.6488G>C/c.14814C>G	{"RYR1": {"c.6488G>C": 1, "c.14814C>G": 1}}	\N
7942763	7941119	c.7373G>T/c.12355A>T	{"RYR1": {"c.7373G>T": 1, "c.12355A>T": 1}}	\N
7942764	7941119	c.1565A>G/c.12383C>T	{"RYR1": {"c.1565A>G": 1, "c.12383C>T": 1}}	\N
7942765	7941119	c.3166G>C/c.3656A>C	{"RYR1": {"c.3166G>C": 1, "c.3656A>C": 1}}	\N
7942766	7941119	c.742G>A/c.12115A>T	{"RYR1": {"c.742G>A": 1, "c.12115A>T": 1}}	\N
7942767	7941119	c.496G>A/c.1565A>C	{"RYR1": {"c.496G>A": 1, "c.1565A>C": 1}}	\N
7942768	7941119	c.496G>A/c.533A>G	{"RYR1": {"c.496G>A": 1, "c.533A>G": 1}}	\N
7942769	7941119	c.6502G>A/c.9635A>G	{"RYR1": {"c.6502G>A": 1, "c.9635A>G": 1}}	\N
7942770	7941119	c.496G>A/c.1565A>G	{"RYR1": {"c.496G>A": 1, "c.1565A>G": 1}}	\N
7942771	7941119	c.1840C>T/c.13918A>G	{"RYR1": {"c.1840C>T": 1, "c.13918A>G": 1}}	\N
7942772	7941119	c.6487C>T/c.13913G>A	{"RYR1": {"c.6487C>T": 1, "c.13913G>A": 1}}	\N
7942773	7941119	c.103T>C/c.13672C>T	{"RYR1": {"c.103T>C": 1, "c.13672C>T": 1}}	\N
7942774	7941119	c.7291G>A/c.14051T>C	{"RYR1": {"c.7291G>A": 1, "c.14051T>C": 1}}	\N
7942775	7941119	c.6488G>A/c.13994_13995delTCinsCT	{"RYR1": {"c.6488G>A": 1, "c.13994_13995delTCinsCT": 1}}	\N
7942776	7941119	c.488G>A/c.8026C>T	{"RYR1": {"c.488G>A": 1, "c.8026C>T": 1}}	\N
7942777	7941119	c.3127C>T/c.7084G>A	{"RYR1": {"c.3127C>T": 1, "c.7084G>A": 1}}	\N
7942778	7941119	c.14424C>A/c.14539G>C	{"RYR1": {"c.14424C>A": 1, "c.14539G>C": 1}}	\N
7942779	7941119	c.6488G>C/c.13672C>T	{"RYR1": {"c.6488G>C": 1, "c.13672C>T": 1}}	\N
7942780	7941119	c.7073T>A/c.7372C>T	{"RYR1": {"c.7073T>A": 1, "c.7372C>T": 1}}	\N
7942781	7941119	c.1615T>G/c.13990T>C	{"RYR1": {"c.1615T>G": 1, "c.13990T>C": 1}}	\N
7942782	7941119	c.7076G>A/c.14813T>C	{"RYR1": {"c.7076G>A": 1, "c.14813T>C": 1}}	\N
7942783	7941119	c.992_994dup/c.8026C>T	{"RYR1": {"c.8026C>T": 1, "c.992_994dup": 1}}	\N
7942784	7941119	c.9758T>C/c.11315G>A	{"RYR1": {"c.9758T>C": 1, "c.11315G>A": 1}}	\N
7942785	7941119	c.6617C>T/c.10229C>A	{"RYR1": {"c.6617C>T": 1, "c.10229C>A": 1}}	\N
7942786	7941119	c.7035C>A/c.7085A>G	{"RYR1": {"c.7035C>A": 1, "c.7085A>G": 1}}	\N
7942787	7941119	c.4400A>G/c.7360C>T	{"RYR1": {"c.4400A>G": 1, "c.7360C>T": 1}}	\N
7942788	7941119	c.6612C>G/c.13702C>G	{"RYR1": {"c.6612C>G": 1, "c.13702C>G": 1}}	\N
7942789	7941119	c.7090T>G/c.8189A>G	{"RYR1": {"c.7090T>G": 1, "c.8189A>G": 1}}	\N
7942790	7941119	c.7358T>C/c.14818G>A	{"RYR1": {"c.7358T>C": 1, "c.14818G>A": 1}}	\N
7942791	7941119	c.1201C>T/c.14471T>C	{"RYR1": {"c.1201C>T": 1, "c.14471T>C": 1}}	\N
7942792	7941119	c.1565A>G/c.3172G>A	{"RYR1": {"c.1565A>G": 1, "c.3172G>A": 1}}	\N
7942793	7941119	c.11969G>T/c.13934G>A	{"RYR1": {"c.11969G>T": 1, "c.13934G>A": 1}}	\N
7942794	7941119	c.7007G>A/c.13702C>G	{"RYR1": {"c.7007G>A": 1, "c.13702C>G": 1}}	\N
7942795	7941119	c.7522C>T/c.9850T>A	{"RYR1": {"c.7522C>T": 1, "c.9850T>A": 1}}	\N
7942796	7941119	c.9310G>A/c.11132C>T	{"RYR1": {"c.9310G>A": 1, "c.11132C>T": 1}}	\N
7942797	7941119	c.38T>G/c.1459C>G	{"RYR1": {"c.38T>G": 1, "c.1459C>G": 1}}	\N
7942798	7941119	c.13994_13995delTCinsCT/c.14918C>T	{"RYR1": {"c.14918C>T": 1, "c.13994_13995delTCinsCT": 1}}	\N
7942799	7941119	c.1598G>A/c.14539G>C	{"RYR1": {"c.1598G>A": 1, "c.14539G>C": 1}}	\N
7942800	7941119	c.7373G>A/c.10042C>T	{"RYR1": {"c.7373G>A": 1, "c.10042C>T": 1}}	\N
7942801	7941119	c.130C>T/c.6635T>A	{"RYR1": {"c.130C>T": 1, "c.6635T>A": 1}}	\N
7942802	7941119	c.1202G>A/c.9868G>A	{"RYR1": {"c.1202G>A": 1, "c.9868G>A": 1}}	\N
7942803	7941119	c.11813G>A/c.12700G>T	{"RYR1": {"c.11813G>A": 1, "c.12700G>T": 1}}	\N
7942804	7941119	c.488G>A/c.1615T>C	{"RYR1": {"c.488G>A": 1, "c.1615T>C": 1}}	\N
7942805	7941119	c.7048G>A/c.9850T>A	{"RYR1": {"c.7048G>A": 1, "c.9850T>A": 1}}	\N
7942806	7941119	c.742G>C/c.12115A>T	{"RYR1": {"c.742G>C": 1, "c.12115A>T": 1}}	\N
7942807	7941119	c.1841G>T/c.3656A>C	{"RYR1": {"c.1841G>T": 1, "c.3656A>C": 1}}	\N
7942808	7941119	c.130C>T/c.7355G>C	{"RYR1": {"c.130C>T": 1, "c.7355G>C": 1}}	\N
7942809	7941119	c.7124G>C/c.10556C>T	{"RYR1": {"c.7124G>C": 1, "c.10556C>T": 1}}	\N
7942810	7941119	c.680A>T/c.7304G>T	{"RYR1": {"c.680A>T": 1, "c.7304G>T": 1}}	\N
7942811	7941119	c.2050G>C/c.11708G>A	{"RYR1": {"c.2050G>C": 1, "c.11708G>A": 1}}	\N
7942812	7941119	c.6488G>T/c.12689T>G	{"RYR1": {"c.6488G>T": 1, "c.12689T>G": 1}}	\N
7942813	7941119	c.3527C>T/c.7372C>T	{"RYR1": {"c.3527C>T": 1, "c.7372C>T": 1}}	\N
7942814	7941119	c.529C>T/c.11120G>T	{"RYR1": {"c.529C>T": 1, "c.11120G>T": 1}}	\N
7942815	7941119	c.488G>A/c.6349G>C	{"RYR1": {"c.488G>A": 1, "c.6349G>C": 1}}	\N
7942816	7941119	c.8054C>T/c.12700G>C	{"RYR1": {"c.8054C>T": 1, "c.12700G>C": 1}}	\N
7942817	7941119	c.488G>A/c.1615T>G	{"RYR1": {"c.488G>A": 1, "c.1615T>G": 1}}	\N
7942818	7941119	c.3166G>A/c.7060G>A	{"RYR1": {"c.3166G>A": 1, "c.7060G>A": 1}}	\N
7942819	7941119	c.7373G>A/c.8654C>G	{"RYR1": {"c.7373G>A": 1, "c.8654C>G": 1}}	\N
7942820	7941119	c.7487C>T/c.14209C>T	{"RYR1": {"c.7487C>T": 1, "c.14209C>T": 1}}	\N
7942821	7941119	c.680A>T/c.1565A>C	{"RYR1": {"c.680A>T": 1, "c.1565A>C": 1}}	\N
7942822	7941119	c.130C>T/c.7355G>A	{"RYR1": {"c.130C>T": 1, "c.7355G>A": 1}}	\N
7942823	7941119	c.680A>T/c.1565A>G	{"RYR1": {"c.680A>T": 1, "c.1565A>G": 1}}	\N
7942824	7941119	c.8054C>T/c.12700G>T	{"RYR1": {"c.8054C>T": 1, "c.12700G>T": 1}}	\N
7942825	7941119	c.680A>T/c.7304G>A	{"RYR1": {"c.680A>T": 1, "c.7304G>A": 1}}	\N
7942826	7941119	c.8005G>A/c.14512C>G	{"RYR1": {"c.8005G>A": 1, "c.14512C>G": 1}}	\N
7942827	7941119	c.11813G>A/c.12700G>C	{"RYR1": {"c.11813G>A": 1, "c.12700G>C": 1}}	\N
7942828	7941119	c.11126C>T/c.12149C>A	{"RYR1": {"c.11126C>T": 1, "c.12149C>A": 1}}	\N
7942829	7941119	c.2537C>T/c.14918C>T	{"RYR1": {"c.2537C>T": 1, "c.14918C>T": 1}}	\N
7942830	7941119	c.1565A>G/c.8054C>T	{"RYR1": {"c.1565A>G": 1, "c.8054C>T": 1}}	\N
7942831	7941119	c.7787C>T/c.14477C>T	{"RYR1": {"c.7787C>T": 1, "c.14477C>T": 1}}	\N
7942832	7941119	c.14581C>T/c.14918C>T	{"RYR1": {"c.14581C>T": 1, "c.14918C>T": 1}}	\N
7942833	7941119	c.7360C>T/c.11953T>C	{"RYR1": {"c.7360C>T": 1, "c.11953T>C": 1}}	\N
7942834	7941119	c.14678G>A/c.14803G>A	{"RYR1": {"c.14678G>A": 1, "c.14803G>A": 1}}	\N
7942835	7941119	c.7317G>C/c.7879G>C	{"RYR1": {"c.7317G>C": 1, "c.7879G>C": 1}}	\N
7942836	7941119	c.190T>C/c.1202G>T	{"RYR1": {"c.190T>C": 1, "c.1202G>T": 1}}	\N
7942837	7941119	c.1840C>T/c.14449A>T	{"RYR1": {"c.1840C>T": 1, "c.14449A>T": 1}}	\N
7942838	7941119	c.7032G>C/c.7358T>C	{"RYR1": {"c.7032G>C": 1, "c.7358T>C": 1}}	\N
7942839	7941119	c.1589G>A/c.10229C>A	{"RYR1": {"c.1589G>A": 1, "c.10229C>A": 1}}	\N
7942840	7941119	c.6387C>G/c.6548G>A	{"RYR1": {"c.6387C>G": 1, "c.6548G>A": 1}}	\N
7942841	7941119	c.14387A>G/c.14477C>T	{"RYR1": {"c.14387A>G": 1, "c.14477C>T": 1}}	\N
7942842	7941119	c.3166G>C/c.11723A>T	{"RYR1": {"c.3166G>C": 1, "c.11723A>T": 1}}	\N
7942843	7941119	c.533A>G/c.8005G>A	{"RYR1": {"c.533A>G": 1, "c.8005G>A": 1}}	\N
7942844	7941119	c.2924G>A/c.11708G>A	{"RYR1": {"c.2924G>A": 1, "c.11708G>A": 1}}	\N
7942845	7941119	c.190T>C/c.1202G>A	{"RYR1": {"c.190T>C": 1, "c.1202G>A": 1}}	\N
7942846	7941119	c.529C>T/c.1100G>A	{"RYR1": {"c.529C>T": 1, "c.1100G>A": 1}}	\N
7942847	7941119	c.10229C>A/c.12149C>A	{"RYR1": {"c.10229C>A": 1, "c.12149C>A": 1}}	\N
7942848	7941119	c.742G>A/c.13990T>C	{"RYR1": {"c.742G>A": 1, "c.13990T>C": 1}}	\N
7942849	7941119	c.7354C>T/c.14364+1G>T	{"RYR1": {"c.7354C>T": 1, "c.14364+1G>T": 1}}	\N
7942850	7941119	c.178G>T/c.7042_7044delGAG	{"RYR1": {"c.178G>T": 1, "c.7042_7044delGAG": 1}}	\N
7942851	7941119	c.982C>T/c.8729C>T	{"RYR1": {"c.982C>T": 1, "c.8729C>T": 1}}	\N
7942852	7941119	c.529C>T/c.1100G>T	{"RYR1": {"c.529C>T": 1, "c.1100G>T": 1}}	\N
7942853	7941119	c.3527C>T/c.7300G>A	{"RYR1": {"c.3527C>T": 1, "c.7300G>A": 1}}	\N
7942854	7941119	c.6349G>C/c.14678G>A	{"RYR1": {"c.6349G>C": 1, "c.14678G>A": 1}}	\N
7942855	7941119	c.178G>T/c.7063C>T	{"RYR1": {"c.178G>T": 1, "c.7063C>T": 1}}	\N
7942856	7941119	c.14524G>A/c.14918C>T	{"RYR1": {"c.14524G>A": 1, "c.14918C>T": 1}}	\N
7942857	7941119	c.1630G>T/c.3166G>A	{"RYR1": {"c.1630G>T": 1, "c.3166G>A": 1}}	\N
7942858	7941119	c.130C>T/c.7073T>A	{"RYR1": {"c.130C>T": 1, "c.7073T>A": 1}}	\N
7942859	7941119	c.5183C>T/c.9268G>A	{"RYR1": {"c.5183C>T": 1, "c.9268G>A": 1}}	\N
7942860	7941119	c.6640G>A/c.7304G>T	{"RYR1": {"c.6640G>A": 1, "c.7304G>T": 1}}	\N
7942861	7941119	c.3527C>T/c.7879G>C	{"RYR1": {"c.3527C>T": 1, "c.7879G>C": 1}}	\N
7942862	7941119	c.5024T>C/c.6838G>A	{"RYR1": {"c.5024T>C": 1, "c.6838G>A": 1}}	\N
7942863	7941119	c.7035C>A/c.14471T>C	{"RYR1": {"c.7035C>A": 1, "c.14471T>C": 1}}	\N
7942864	7941119	c.1565A>G/c.6304G>C	{"RYR1": {"c.1565A>G": 1, "c.6304G>C": 1}}	\N
7942865	7941119	c.1840C>T/c.14825G>T	{"RYR1": {"c.1840C>T": 1, "c.14825G>T": 1}}	\N
7942866	7941119	c.1834G>C/c.6838G>A	{"RYR1": {"c.1834G>C": 1, "c.6838G>A": 1}}	\N
7942867	7941119	c.1201C>A/c.14512C>G	{"RYR1": {"c.1201C>A": 1, "c.14512C>G": 1}}	\N
7942868	7941119	c.1201C>T/c.10043G>A	{"RYR1": {"c.1201C>T": 1, "c.10043G>A": 1}}	\N
7942869	7941119	c.1144C>A/c.6487C>T	{"RYR1": {"c.1144C>A": 1, "c.6487C>T": 1}}	\N
7942870	7941119	c.7304G>A/c.14813T>C	{"RYR1": {"c.7304G>A": 1, "c.14813T>C": 1}}	\N
7942871	7941119	c.463C>A/c.10042C>T	{"RYR1": {"c.463C>A": 1, "c.10042C>T": 1}}	\N
7942872	7941119	c.38T>G/c.14422_14423delinsAA	{"RYR1": {"c.38T>G": 1, "c.14422_14423delinsAA": 1}}	\N
7942873	7941119	c.7063C>T/c.14582G>A	{"RYR1": {"c.7063C>T": 1, "c.14582G>A": 1}}	\N
7942874	7941119	c.1615T>C/c.12115A>T	{"RYR1": {"c.1615T>C": 1, "c.12115A>T": 1}}	\N
7942875	7941119	c.463C>A/c.7760A>G	{"RYR1": {"c.463C>A": 1, "c.7760A>G": 1}}	\N
7942876	7941119	c.4747C>T/c.7090T>G	{"RYR1": {"c.4747C>T": 1, "c.7090T>G": 1}}	\N
7942877	7941119	c.7123G>A/c.14424C>A	{"RYR1": {"c.7123G>A": 1, "c.14424C>A": 1}}	\N
7942878	7941119	c.1597C>T/c.8729C>T	{"RYR1": {"c.1597C>T": 1, "c.8729C>T": 1}}	\N
7942879	7941119	c.7035C>A/c.7099G>A	{"RYR1": {"c.7035C>A": 1, "c.7099G>A": 1}}	\N
7942880	7941119	c.1565A>G/c.13673G>A	{"RYR1": {"c.1565A>G": 1, "c.13673G>A": 1}}	\N
7942881	7941119	c.742G>A/c.11748T>G	{"RYR1": {"c.742G>A": 1, "c.11748T>G": 1}}	\N
7942882	7941119	c.742G>C/c.13990T>C	{"RYR1": {"c.742G>C": 1, "c.13990T>C": 1}}	\N
7942883	7941119	c.14545G>A/c.14818G>A	{"RYR1": {"c.14545G>A": 1, "c.14818G>A": 1}}	\N
7942884	7941119	c.7373G>T/c.14814C>G	{"RYR1": {"c.7373G>T": 1, "c.14814C>G": 1}}	\N
7942885	7941119	c.190T>C/c.14209C>T	{"RYR1": {"c.190T>C": 1, "c.14209C>T": 1}}	\N
7942886	7941119	c.6487C>T/c.9758T>C	{"RYR1": {"c.6487C>T": 1, "c.9758T>C": 1}}	\N
7942887	7941119	c.38T>G/c.12413T>C	{"RYR1": {"c.38T>G": 1, "c.12413T>C": 1}}	\N
7942888	7941119	c.7282G>A/c.7777C>G	{"RYR1": {"c.7282G>A": 1, "c.7777C>G": 1}}	\N
7942889	7941119	c.7043A>G/c.14567C>G	{"RYR1": {"c.7043A>G": 1, "c.14567C>G": 1}}	\N
7942890	7941119	c.7310C>T/c.7771C>T	{"RYR1": {"c.7310C>T": 1, "c.7771C>T": 1}}	\N
7942891	7941119	c.7372C>T/c.12553G>A	{"RYR1": {"c.7372C>T": 1, "c.12553G>A": 1}}	\N
7942892	7941119	c.1202G>A/c.14509C>G	{"RYR1": {"c.1202G>A": 1, "c.14509C>G": 1}}	\N
7942893	7941119	c.1840C>T/c.8518C>T	{"RYR1": {"c.1840C>T": 1, "c.8518C>T": 1}}	\N
7942894	7941119	c.1202G>A/c.7099G>A	{"RYR1": {"c.1202G>A": 1, "c.7099G>A": 1}}	\N
7942895	7941119	c.1422G>T/c.7522C>T	{"RYR1": {"c.1422G>T": 1, "c.7522C>T": 1}}	\N
7942896	7941119	c.1100G>A/c.11708G>A	{"RYR1": {"c.1100G>A": 1, "c.11708G>A": 1}}	\N
7942897	7941119	c.8026C>T/c.10042C>T	{"RYR1": {"c.8026C>T": 1, "c.10042C>T": 1}}	\N
7942898	7941119	c.1202G>T/c.5186T>G	{"RYR1": {"c.1202G>T": 1, "c.5186T>G": 1}}	\N
7942899	7941119	c.1654C>T/c.13673G>A	{"RYR1": {"c.1654C>T": 1, "c.13673G>A": 1}}	\N
7942900	7941119	c.14210G>A/c.14458G>T	{"RYR1": {"c.14210G>A": 1, "c.14458G>T": 1}}	\N
7942901	7941119	c.7291G>T/c.14879T>A	{"RYR1": {"c.7291G>T": 1, "c.14879T>A": 1}}	\N
7942902	7941119	c.7075C>T/c.7310C>T	{"RYR1": {"c.7075C>T": 1, "c.7310C>T": 1}}	\N
7942903	7941119	c.1654C>T/c.3172G>A	{"RYR1": {"c.1654C>T": 1, "c.3172G>A": 1}}	\N
7942904	7941119	c.487C>T/c.10043G>A	{"RYR1": {"c.487C>T": 1, "c.10043G>A": 1}}	\N
7942905	7941119	c.3166G>A/c.7084G>A	{"RYR1": {"c.3166G>A": 1, "c.7084G>A": 1}}	\N
7942906	7941119	c.946C>T/c.11708G>A	{"RYR1": {"c.946C>T": 1, "c.11708G>A": 1}}	\N
7942907	7941119	c.7075C>T/c.14545G>A	{"RYR1": {"c.7075C>T": 1, "c.14545G>A": 1}}	\N
7942908	7941119	c.178G>A/c.1589G>A	{"RYR1": {"c.178G>A": 1, "c.1589G>A": 1}}	\N
7942909	7941119	c.493G>A/c.7300G>A	{"RYR1": {"c.493G>A": 1, "c.7300G>A": 1}}	\N
7942910	7941119	c.1840C>T/c.12064A>G	{"RYR1": {"c.1840C>T": 1, "c.12064A>G": 1}}	\N
7942911	7941119	c.6671G>A/c.11708G>A	{"RYR1": {"c.6671G>A": 1, "c.11708G>A": 1}}	\N
7942912	7941119	c.7523G>A/c.14186A>C	{"RYR1": {"c.7523G>A": 1, "c.14186A>C": 1}}	\N
7942913	7941119	c.131G>A/c.14512C>G	{"RYR1": {"c.131G>A": 1, "c.14512C>G": 1}}	\N
7942914	7941119	c.7355G>A/c.14512C>G	{"RYR1": {"c.7355G>A": 1, "c.14512C>G": 1}}	\N
7942915	7941119	c.742G>C/c.11748T>G	{"RYR1": {"c.742G>C": 1, "c.11748T>G": 1}}	\N
7942916	7941119	c.7879G>C/c.11120G>T	{"RYR1": {"c.7879G>C": 1, "c.11120G>T": 1}}	\N
7942917	7941119	c.14539G>C/c.14567C>G	{"RYR1": {"c.14539G>C": 1, "c.14567C>G": 1}}	\N
7942918	7941119	c.7043A>G/c.8729C>T	{"RYR1": {"c.7043A>G": 1, "c.8729C>T": 1}}	\N
7942919	7941119	c.11708G>A/c.14558C>T	{"RYR1": {"c.11708G>A": 1, "c.14558C>T": 1}}	\N
7942920	7941119	c.7090T>G/c.8729C>T	{"RYR1": {"c.7090T>G": 1, "c.8729C>T": 1}}	\N
7942921	7941119	c.4400A>G/c.7372C>T	{"RYR1": {"c.4400A>G": 1, "c.7372C>T": 1}}	\N
7942922	7941119	c.6617C>T/c.7385C>T	{"RYR1": {"c.6617C>T": 1, "c.7385C>T": 1}}	\N
7942923	7941119	c.11315G>A/c.14680G>A	{"RYR1": {"c.11315G>A": 1, "c.14680G>A": 1}}	\N
7942924	7941119	c.1201C>T/c.6377G>A	{"RYR1": {"c.1201C>T": 1, "c.6377G>A": 1}}	\N
7942925	7941119	c.7373G>T/c.13934G>A	{"RYR1": {"c.7373G>T": 1, "c.13934G>A": 1}}	\N
7942926	7941119	c.4775C>T/c.7043A>G	{"RYR1": {"c.4775C>T": 1, "c.7043A>G": 1}}	\N
7942927	7941119	c.528G>T/c.6612C>G	{"RYR1": {"c.528G>T": 1, "c.6612C>G": 1}}	\N
7942928	7941119	c.1565A>C/c.8054C>T	{"RYR1": {"c.1565A>C": 1, "c.8054C>T": 1}}	\N
7942929	7941119	c.7304G>T/c.11518G>A	{"RYR1": {"c.7304G>T": 1, "c.11518G>A": 1}}	\N
7942930	7941119	c.14210G>A/c.14458G>A	{"RYR1": {"c.14210G>A": 1, "c.14458G>A": 1}}	\N
7942931	7941119	c.10043G>A/c.14545G>A	{"RYR1": {"c.10043G>A": 1, "c.14545G>A": 1}}	\N
7942932	7941119	c.1840C>T/c.6710G>A	{"RYR1": {"c.1840C>T": 1, "c.6710G>A": 1}}	\N
7942933	7941119	c.742G>C/c.7787C>T	{"RYR1": {"c.742G>C": 1, "c.7787C>T": 1}}	\N
7942934	7941119	c.3166G>C/c.6599C>T	{"RYR1": {"c.3166G>C": 1, "c.6599C>T": 1}}	\N
7942935	7941119	c.487C>T/c.13990T>C	{"RYR1": {"c.487C>T": 1, "c.13990T>C": 1}}	\N
7942936	7941119	c.467G>A/c.6488G>A	{"RYR1": {"c.467G>A": 1, "c.6488G>A": 1}}	\N
7942937	7941119	c.1615T>C/c.7075C>T	{"RYR1": {"c.1615T>C": 1, "c.7075C>T": 1}}	\N
7942938	7941119	c.6617C>G/c.14581C>T	{"RYR1": {"c.6617C>G": 1, "c.14581C>T": 1}}	\N
7942939	7941119	c.7304G>A/c.9797T>C	{"RYR1": {"c.7304G>A": 1, "c.9797T>C": 1}}	\N
7942940	7941119	c.3095G>A/c.9310G>A	{"RYR1": {"c.3095G>A": 1, "c.9310G>A": 1}}	\N
7942941	7941119	c.467G>A/c.6488G>C	{"RYR1": {"c.467G>A": 1, "c.6488G>C": 1}}	\N
7942942	7941119	c.1021G>A/c.13934G>A	{"RYR1": {"c.1021G>A": 1, "c.13934G>A": 1}}	\N
7942943	7941119	c.7043A>G/c.12121C>T	{"RYR1": {"c.7043A>G": 1, "c.12121C>T": 1}}	\N
7942944	7941119	c.190T>C/c.7291G>A	{"RYR1": {"c.190T>C": 1, "c.7291G>A": 1}}	\N
7942945	7941119	c.7361G>A/c.15059G>C	{"RYR1": {"c.7361G>A": 1, "c.15059G>C": 1}}	\N
7942946	7941119	c.7487C>T/c.7879G>C	{"RYR1": {"c.7487C>T": 1, "c.7879G>C": 1}}	\N
7942947	7941119	c.10229C>A/c.14918C>T	{"RYR1": {"c.10229C>A": 1, "c.14918C>T": 1}}	\N
7942948	7941119	c.487C>T/c.641C>T	{"RYR1": {"c.487C>T": 1, "c.641C>T": 1}}	\N
7942949	7941119	c.7075C>T/c.14627A>G	{"RYR1": {"c.7075C>T": 1, "c.14627A>G": 1}}	\N
7942950	7941119	c.1565A>C/c.5441T>A	{"RYR1": {"c.1565A>C": 1, "c.5441T>A": 1}}	\N
7942951	7941119	c.6617C>G/c.10229C>A	{"RYR1": {"c.6617C>G": 1, "c.10229C>A": 1}}	\N
7942952	7941119	c.7355G>C/c.14512C>G	{"RYR1": {"c.7355G>C": 1, "c.14512C>G": 1}}	\N
7942953	7941119	c.467G>A/c.6488G>T	{"RYR1": {"c.467G>A": 1, "c.6488G>T": 1}}	\N
7942954	7941119	c.1615T>G/c.12115A>T	{"RYR1": {"c.1615T>G": 1, "c.12115A>T": 1}}	\N
7942955	7941119	c.7291G>T/c.14051T>C	{"RYR1": {"c.7291G>T": 1, "c.14051T>C": 1}}	\N
7942956	7941119	c.14627A>G/c.15060G>C	{"RYR1": {"c.14627A>G": 1, "c.15060G>C": 1}}	\N
7942957	7941119	c.1589G>A/c.12064A>G	{"RYR1": {"c.1589G>A": 1, "c.12064A>G": 1}}	\N
7942958	7941119	c.7076G>A/c.14002C>T	{"RYR1": {"c.7076G>A": 1, "c.14002C>T": 1}}	\N
7942959	7941119	c.677T>A/c.1589G>A	{"RYR1": {"c.677T>A": 1, "c.1589G>A": 1}}	\N
7942960	7941119	c.1589G>A/c.3166G>A	{"RYR1": {"c.1589G>A": 1, "c.3166G>A": 1}}	\N
7942961	7941119	c.1589G>A/c.9652G>A	{"RYR1": {"c.1589G>A": 1, "c.9652G>A": 1}}	\N
7942962	7941119	c.178G>A/c.11969G>T	{"RYR1": {"c.178G>A": 1, "c.11969G>T": 1}}	\N
7942963	7941119	c.4400A>G/c.14209C>T	{"RYR1": {"c.4400A>G": 1, "c.14209C>T": 1}}	\N
7942964	7941119	c.6838G>A/c.9268G>A	{"RYR1": {"c.6838G>A": 1, "c.9268G>A": 1}}	\N
7942965	7941119	c.14210G>A/c.14817C>A	{"RYR1": {"c.14210G>A": 1, "c.14817C>A": 1}}	\N
7942966	7941119	c.463C>A/c.7018T>C	{"RYR1": {"c.463C>A": 1, "c.7018T>C": 1}}	\N
7942967	7941119	c.6488G>A/c.9356G>A	{"RYR1": {"c.6488G>A": 1, "c.9356G>A": 1}}	\N
7942968	7941119	c.7361G>A/c.15060G>C	{"RYR1": {"c.7361G>A": 1, "c.15060G>C": 1}}	\N
7942969	7941119	c.11416G>A/c.14512C>G	{"RYR1": {"c.11416G>A": 1, "c.14512C>G": 1}}	\N
7942970	7941119	c.463C>A/c.7085A>G	{"RYR1": {"c.463C>A": 1, "c.7085A>G": 1}}	\N
7942971	7941119	c.7063C>T/c.12121C>T	{"RYR1": {"c.7063C>T": 1, "c.12121C>T": 1}}	\N
7942972	7941119	c.1021G>A/c.6640G>A	{"RYR1": {"c.1021G>A": 1, "c.6640G>A": 1}}	\N
7942973	7941119	c.212C>A/c.1630G>T	{"RYR1": {"c.212C>A": 1, "c.1630G>T": 1}}	\N
7942974	7941119	c.3166G>A/c.14497C>T	{"RYR1": {"c.3166G>A": 1, "c.14497C>T": 1}}	\N
7942975	7941119	c.1460T>C/c.6838G>A	{"RYR1": {"c.1460T>C": 1, "c.6838G>A": 1}}	\N
7942976	7941119	c.7361G>A/c.8005G>A	{"RYR1": {"c.7361G>A": 1, "c.8005G>A": 1}}	\N
7942977	7941119	c.7879G>C/c.12553G>A	{"RYR1": {"c.7879G>C": 1, "c.12553G>A": 1}}	\N
7942978	7941119	c.1597C>T/c.14818G>A	{"RYR1": {"c.1597C>T": 1, "c.14818G>A": 1}}	\N
7942979	7941119	c.7060G>A/c.8290G>A	{"RYR1": {"c.7060G>A": 1, "c.8290G>A": 1}}	\N
7942980	7941119	c.38T>G/c.6478G>A	{"RYR1": {"c.38T>G": 1, "c.6478G>A": 1}}	\N
7942981	7941119	c.6628G>T/c.7307G>A	{"RYR1": {"c.6628G>T": 1, "c.7307G>A": 1}}	\N
7942982	7941119	c.1201C>T/c.13934G>A	{"RYR1": {"c.1201C>T": 1, "c.13934G>A": 1}}	\N
7942983	7941119	c.2122G>A/c.7373G>T	{"RYR1": {"c.2122G>A": 1, "c.7373G>T": 1}}	\N
7942984	7941119	c.14539G>C/c.14818G>A	{"RYR1": {"c.14539G>C": 1, "c.14818G>A": 1}}	\N
7942985	7941119	c.493G>A/c.7060G>A	{"RYR1": {"c.493G>A": 1, "c.7060G>A": 1}}	\N
7942986	7941119	c.677T>A/c.14209C>T	{"RYR1": {"c.677T>A": 1, "c.14209C>T": 1}}	\N
7942987	7941119	c.6488G>C/c.8600T>A	{"RYR1": {"c.6488G>C": 1, "c.8600T>A": 1}}	\N
7942988	7941119	c.14627A>G/c.15059G>C	{"RYR1": {"c.14627A>G": 1, "c.15059G>C": 1}}	\N
7942989	7941119	c.6488G>A/c.14364+1G>T	{"RYR1": {"c.6488G>A": 1, "c.14364+1G>T": 1}}	\N
7942990	7941119	c.6502G>A/c.14424C>A	{"RYR1": {"c.6502G>A": 1, "c.14424C>A": 1}}	\N
7942991	7941119	c.7522C>T/c.10043G>A	{"RYR1": {"c.7522C>T": 1, "c.10043G>A": 1}}	\N
7942992	7941119	c.7090T>G/c.14582G>A	{"RYR1": {"c.7090T>G": 1, "c.14582G>A": 1}}	\N
7942993	7941119	c.6617C>T/c.10556C>T	{"RYR1": {"c.6617C>T": 1, "c.10556C>T": 1}}	\N
7942994	7941119	c.2122G>A/c.7373G>A	{"RYR1": {"c.2122G>A": 1, "c.7373G>A": 1}}	\N
7942995	7941119	c.497A>G/c.14477C>T	{"RYR1": {"c.497A>G": 1, "c.14477C>T": 1}}	\N
7942996	7941119	c.14201G>A/c.14210G>A	{"RYR1": {"c.14201G>A": 1, "c.14210G>A": 1}}	\N
7942997	7941119	c.251C>T/c.14918C>T	{"RYR1": {"c.251C>T": 1, "c.14918C>T": 1}}	\N
7942998	7941119	c.677T>A/c.7124G>C	{"RYR1": {"c.677T>A": 1, "c.7124G>C": 1}}	\N
7942999	7941119	c.130C>T/c.497A>G	{"RYR1": {"c.130C>T": 1, "c.497A>G": 1}}	\N
7943000	7941119	c.946C>T/c.9310G>A	{"RYR1": {"c.946C>T": 1, "c.9310G>A": 1}}	\N
7943001	7941119	c.742G>A/c.7787C>T	{"RYR1": {"c.742G>A": 1, "c.7787C>T": 1}}	\N
7943002	7941119	c.7043A>G/c.14817C>A	{"RYR1": {"c.7043A>G": 1, "c.14817C>A": 1}}	\N
7943003	7941119	c.1841G>T/c.14680G>A	{"RYR1": {"c.1841G>T": 1, "c.14680G>A": 1}}	\N
7943004	7941119	c.12700G>T/c.14680G>A	{"RYR1": {"c.12700G>T": 1, "c.14680G>A": 1}}	\N
7943005	7941119	c.251C>T/c.6349G>C	{"RYR1": {"c.251C>T": 1, "c.6349G>C": 1}}	\N
7943006	7941119	c.1201C>G/c.7042_7044delGAG	{"RYR1": {"c.1201C>G": 1, "c.7042_7044delGAG": 1}}	\N
7943007	7941119	c.1021G>C/c.6640G>A	{"RYR1": {"c.1021G>C": 1, "c.6640G>A": 1}}	\N
7943008	7941119	c.7310C>T/c.14825G>T	{"RYR1": {"c.7310C>T": 1, "c.14825G>T": 1}}	\N
7943009	7941119	c.6617C>G/c.9676G>C	{"RYR1": {"c.6617C>G": 1, "c.9676G>C": 1}}	\N
7943010	7941119	c.7307G>A/c.14477C>T	{"RYR1": {"c.7307G>A": 1, "c.14477C>T": 1}}	\N
7943011	7941119	c.1597C>T/c.6671G>A	{"RYR1": {"c.1597C>T": 1, "c.6671G>A": 1}}	\N
7943012	7941119	c.5441T>A/c.6502G>A	{"RYR1": {"c.5441T>A": 1, "c.6502G>A": 1}}	\N
7943013	7941119	c.7373G>A/c.12355A>T	{"RYR1": {"c.7373G>A": 1, "c.12355A>T": 1}}	\N
7943014	7941119	c.14051T>C/c.14209C>T	{"RYR1": {"c.14051T>C": 1, "c.14209C>T": 1}}	\N
7943015	7941119	c.1654C>T/c.8654C>G	{"RYR1": {"c.1654C>T": 1, "c.8654C>G": 1}}	\N
7943016	7941119	c.131G>A/c.14477C>T	{"RYR1": {"c.131G>A": 1, "c.14477C>T": 1}}	\N
7943017	7941119	c.6488G>A/c.8600T>A	{"RYR1": {"c.6488G>A": 1, "c.8600T>A": 1}}	\N
7943018	7941119	c.6488G>C/c.14364+1G>T	{"RYR1": {"c.6488G>C": 1, "c.14364+1G>T": 1}}	\N
7943019	7941119	c.7063C>T/c.14567C>G	{"RYR1": {"c.7063C>T": 1, "c.14567C>G": 1}}	\N
7943020	7941119	c.742G>A/c.15059G>C	{"RYR1": {"c.742G>A": 1, "c.15059G>C": 1}}	\N
7943021	7941119	c.7076G>A/c.14693T>C	{"RYR1": {"c.7076G>A": 1, "c.14693T>C": 1}}	\N
7943022	7941119	c.1615T>G/c.7075C>T	{"RYR1": {"c.1615T>G": 1, "c.7075C>T": 1}}	\N
7943023	7941119	c.7291G>T/c.8005G>A	{"RYR1": {"c.7291G>T": 1, "c.8005G>A": 1}}	\N
7943024	7941119	c.7317G>C/c.7372C>T	{"RYR1": {"c.7317G>C": 1, "c.7372C>T": 1}}	\N
7943025	7941119	c.11132C>T/c.14497C>T	{"RYR1": {"c.11132C>T": 1, "c.14497C>T": 1}}	\N
7943026	7941119	c.1589G>A/c.14449A>T	{"RYR1": {"c.1589G>A": 1, "c.14449A>T": 1}}	\N
7943027	7941119	c.1630G>T/c.5186T>G	{"RYR1": {"c.1630G>T": 1, "c.5186T>G": 1}}	\N
7943028	7941119	c.529C>T/c.11947C>T	{"RYR1": {"c.529C>T": 1, "c.11947C>T": 1}}	\N
7943029	7941119	c.5132A>G/c.6838G>A	{"RYR1": {"c.5132A>G": 1, "c.6838G>A": 1}}	\N
7943030	7941119	c.7317G>C/c.7360C>T	{"RYR1": {"c.7317G>C": 1, "c.7360C>T": 1}}	\N
7943031	7941119	c.103T>C/c.11958C>G	{"RYR1": {"c.103T>C": 1, "c.11958C>G": 1}}	\N
7943032	7941119	c.6617C>T/c.12533G>T	{"RYR1": {"c.6617C>T": 1, "c.12533G>T": 1}}	\N
7943033	7941119	c.7487C>T/c.14918C>T	{"RYR1": {"c.7487C>T": 1, "c.14918C>T": 1}}	\N
7943034	7941119	c.652G>A/c.7879G>C	{"RYR1": {"c.652G>A": 1, "c.7879G>C": 1}}	\N
7943035	7941119	c.7358T>C/c.11132C>T	{"RYR1": {"c.7358T>C": 1, "c.11132C>T": 1}}	\N
7943036	7941119	c.7354C>T/c.9848G>A	{"RYR1": {"c.7354C>T": 1, "c.9848G>A": 1}}	\N
7943037	7941119	c.7373G>T/c.9499C>T	{"RYR1": {"c.7373G>T": 1, "c.9499C>T": 1}}	\N
7943038	7941119	c.6502G>A/c.14680G>A	{"RYR1": {"c.6502G>A": 1, "c.14680G>A": 1}}	\N
7943039	7941119	c.3656A>C/c.12149C>A	{"RYR1": {"c.3656A>C": 1, "c.12149C>A": 1}}	\N
7943040	7941119	c.1840C>T/c.2924G>A	{"RYR1": {"c.1840C>T": 1, "c.2924G>A": 1}}	\N
7943041	7941119	c.11132C>T/c.14209C>T	{"RYR1": {"c.11132C>T": 1, "c.14209C>T": 1}}	\N
7943042	7941119	c.1202G>A/c.1460T>C	{"RYR1": {"c.1202G>A": 1, "c.1460T>C": 1}}	\N
7943043	7941119	c.6349G>C/c.11086G>C	{"RYR1": {"c.6349G>C": 1, "c.11086G>C": 1}}	\N
7943044	7941119	c.1201C>A/c.7042_7044delGAG	{"RYR1": {"c.1201C>A": 1, "c.7042_7044delGAG": 1}}	\N
7943045	7941119	c.7291G>T/c.10043G>A	{"RYR1": {"c.7291G>T": 1, "c.10043G>A": 1}}	\N
7943046	7941119	c.496G>A/c.14803G>A	{"RYR1": {"c.496G>A": 1, "c.14803G>A": 1}}	\N
7943047	7941119	c.7291G>A/c.12848A>T	{"RYR1": {"c.7291G>A": 1, "c.12848A>T": 1}}	\N
7943048	7941119	c.7291G>A/c.13918A>G	{"RYR1": {"c.7291G>A": 1, "c.13918A>G": 1}}	\N
7943049	7941119	c.487C>T/c.14879T>A	{"RYR1": {"c.487C>T": 1, "c.14879T>A": 1}}	\N
7943050	7941119	c.6617C>G/c.9652G>A	{"RYR1": {"c.6617C>G": 1, "c.9652G>A": 1}}	\N
7943051	7941119	c.152C>A/c.14512C>G	{"RYR1": {"c.152C>A": 1, "c.14512C>G": 1}}	\N
7943052	7941119	c.6487C>T/c.7487C>T	{"RYR1": {"c.6487C>T": 1, "c.7487C>T": 1}}	\N
7943053	7941119	c.7084G>A/c.14126C>T	{"RYR1": {"c.7084G>A": 1, "c.14126C>T": 1}}	\N
7943054	7941119	c.493G>A/c.7084G>A	{"RYR1": {"c.493G>A": 1, "c.7084G>A": 1}}	\N
7943055	7941119	c.7123G>A/c.14813T>C	{"RYR1": {"c.7123G>A": 1, "c.14813T>C": 1}}	\N
7943056	7941119	c.1654C>T/c.8527T>C	{"RYR1": {"c.1654C>T": 1, "c.8527T>C": 1}}	\N
7943057	7941119	c.4400A>G/c.14497C>T	{"RYR1": {"c.4400A>G": 1, "c.14497C>T": 1}}	\N
7943058	7941119	c.463C>A/c.11813G>A	{"RYR1": {"c.463C>A": 1, "c.11813G>A": 1}}	\N
7943059	7941119	c.97A>G/c.1422G>T	{"RYR1": {"c.97A>G": 1, "c.1422G>T": 1}}	\N
7943060	7941119	c.7358T>C/c.8729C>T	{"RYR1": {"c.7358T>C": 1, "c.8729C>T": 1}}	\N
7943061	7941119	c.7361G>A/c.14879T>A	{"RYR1": {"c.7361G>A": 1, "c.14879T>A": 1}}	\N
7943062	7941119	c.1654C>T/c.13994_13995delTCinsCT	{"RYR1": {"c.1654C>T": 1, "c.13994_13995delTCinsCT": 1}}	\N
7943063	7941119	c.11126C>T/c.14209C>T	{"RYR1": {"c.11126C>T": 1, "c.14209C>T": 1}}	\N
7943064	7941119	c.7018T>C/c.7310C>T	{"RYR1": {"c.7018T>C": 1, "c.7310C>T": 1}}	\N
7943065	7941119	c.14210G>A/c.14782A>G	{"RYR1": {"c.14210G>A": 1, "c.14782A>G": 1}}	\N
7943066	7941119	c.103T>C/c.1422G>T	{"RYR1": {"c.103T>C": 1, "c.1422G>T": 1}}	\N
7943067	7941119	c.7048G>A/c.8638G>A	{"RYR1": {"c.7048G>A": 1, "c.8638G>A": 1}}	\N
7943068	7941119	c.7007G>A/c.13918A>G	{"RYR1": {"c.7007G>A": 1, "c.13918A>G": 1}}	\N
7943069	7941119	c.97A>G/c.6388G>A	{"RYR1": {"c.97A>G": 1, "c.6388G>A": 1}}	\N
7943070	7941119	c.487C>T/c.15060G>C	{"RYR1": {"c.487C>T": 1, "c.15060G>C": 1}}	\N
7943071	7941119	c.7090T>G/c.12398A>G	{"RYR1": {"c.7090T>G": 1, "c.12398A>G": 1}}	\N
7943072	7941119	c.7354C>T/c.7787C>T	{"RYR1": {"c.7354C>T": 1, "c.7787C>T": 1}}	\N
7943073	7941119	c.7073T>A/c.11315G>A	{"RYR1": {"c.7073T>A": 1, "c.11315G>A": 1}}	\N
7943074	7941119	c.2996G>A/c.7310C>T	{"RYR1": {"c.2996G>A": 1, "c.7310C>T": 1}}	\N
7943075	7941119	c.7372C>T/c.11120G>T	{"RYR1": {"c.7372C>T": 1, "c.11120G>T": 1}}	\N
7943076	7941119	c.463C>A/c.14126C>T	{"RYR1": {"c.463C>A": 1, "c.14126C>T": 1}}	\N
7943077	7941119	c.8527T>C/c.14209C>T	{"RYR1": {"c.8527T>C": 1, "c.14209C>T": 1}}	\N
7943078	7941119	c.6838G>A/c.8198G>A	{"RYR1": {"c.6838G>A": 1, "c.8198G>A": 1}}	\N
7943079	7941119	c.7124G>C/c.8290G>A	{"RYR1": {"c.7124G>C": 1, "c.8290G>A": 1}}	\N
7943080	7941119	c.7354C>T/c.13990T>C	{"RYR1": {"c.7354C>T": 1, "c.13990T>C": 1}}	\N
7943081	7941119	c.7291G>A/c.14879T>A	{"RYR1": {"c.7291G>A": 1, "c.14879T>A": 1}}	\N
7943082	7941119	c.6617C>T/c.12064A>G	{"RYR1": {"c.6617C>T": 1, "c.12064A>G": 1}}	\N
7943083	7941119	c.1024G>A/c.11708G>A	{"RYR1": {"c.1024G>A": 1, "c.11708G>A": 1}}	\N
7943084	7941119	c.14387A>G/c.14512C>G	{"RYR1": {"c.14387A>G": 1, "c.14512C>G": 1}}	\N
7943085	7941119	c.1597C>T/c.6478G>A	{"RYR1": {"c.1597C>T": 1, "c.6478G>A": 1}}	\N
7943086	7941119	c.1841G>T/c.11314C>T	{"RYR1": {"c.1841G>T": 1, "c.11314C>T": 1}}	\N
7943087	7941119	c.7124G>C/c.13702C>G	{"RYR1": {"c.7124G>C": 1, "c.13702C>G": 1}}	\N
7943088	7941119	c.7084G>A/c.7099G>A	{"RYR1": {"c.7084G>A": 1, "c.7099G>A": 1}}	\N
7943089	7941119	c.38T>G/c.14818G>A	{"RYR1": {"c.38T>G": 1, "c.14818G>A": 1}}	\N
7943090	7941119	c.479A>G/c.8026C>T	{"RYR1": {"c.479A>G": 1, "c.8026C>T": 1}}	\N
7943091	7941119	c.4400A>G/c.11315G>A	{"RYR1": {"c.4400A>G": 1, "c.11315G>A": 1}}	\N
7943092	7941119	c.1202G>A/c.2996G>A	{"RYR1": {"c.1202G>A": 1, "c.2996G>A": 1}}	\N
7943093	7941119	c.3172G>A/c.14497C>T	{"RYR1": {"c.3172G>A": 1, "c.14497C>T": 1}}	\N
7943094	7941119	c.178G>T/c.7124G>C	{"RYR1": {"c.178G>T": 1, "c.7124G>C": 1}}	\N
7943095	7941119	c.7089C>G/c.14803G>A	{"RYR1": {"c.7089C>G": 1, "c.14803G>A": 1}}	\N
7943096	7941119	c.6628G>T/c.12115A>T	{"RYR1": {"c.6628G>T": 1, "c.12115A>T": 1}}	\N
7943097	7941119	c.528G>T/c.1202G>A	{"RYR1": {"c.528G>T": 1, "c.1202G>A": 1}}	\N
7943098	7941119	c.1565A>G/c.11813G>A	{"RYR1": {"c.1565A>G": 1, "c.11813G>A": 1}}	\N
7943099	7941119	c.6743G>A/c.7373G>T	{"RYR1": {"c.6743G>A": 1, "c.7373G>T": 1}}	\N
7943100	7941119	c.6544A>T/c.7522C>T	{"RYR1": {"c.6544A>T": 1, "c.7522C>T": 1}}	\N
7943101	7941119	c.7292A>T/c.14209C>T	{"RYR1": {"c.7292A>T": 1, "c.14209C>T": 1}}	\N
7943102	7941119	c.742G>A/c.9848G>A	{"RYR1": {"c.742G>A": 1, "c.9848G>A": 1}}	\N
7943103	7941119	c.12149C>A/c.13672C>T	{"RYR1": {"c.12149C>A": 1, "c.13672C>T": 1}}	\N
7943104	7941119	c.6710G>A/c.14477C>T	{"RYR1": {"c.6710G>A": 1, "c.14477C>T": 1}}	\N
7943105	7941119	c.7360C>T/c.12689T>G	{"RYR1": {"c.7360C>T": 1, "c.12689T>G": 1}}	\N
7943106	7941119	c.103T>C/c.9758T>C	{"RYR1": {"c.103T>C": 1, "c.9758T>C": 1}}	\N
7943107	7941119	c.251C>T/c.529C>T	{"RYR1": {"c.251C>T": 1, "c.529C>T": 1}}	\N
7943108	7941119	c.7304G>A/c.12532G>A	{"RYR1": {"c.7304G>A": 1, "c.12532G>A": 1}}	\N
7943109	7941119	c.1589G>A/c.14581C>T	{"RYR1": {"c.1589G>A": 1, "c.14581C>T": 1}}	\N
7943110	7941119	c.6743G>A/c.7373G>A	{"RYR1": {"c.6743G>A": 1, "c.7373G>A": 1}}	\N
7943111	7941119	c.7291G>T/c.7317G>C	{"RYR1": {"c.7291G>T": 1, "c.7317G>C": 1}}	\N
7943112	7941119	c.6847A>C/c.7358T>C	{"RYR1": {"c.6847A>C": 1, "c.7358T>C": 1}}	\N
7943113	7941119	c.487C>T/c.15059G>C	{"RYR1": {"c.487C>T": 1, "c.15059G>C": 1}}	\N
7943114	7941119	c.1654C>T/c.9758T>C	{"RYR1": {"c.1654C>T": 1, "c.9758T>C": 1}}	\N
7943115	7941119	c.6617C>T/c.9652G>A	{"RYR1": {"c.6617C>T": 1, "c.9652G>A": 1}}	\N
7943116	7941119	c.946C>T/c.1630G>T	{"RYR1": {"c.946C>T": 1, "c.1630G>T": 1}}	\N
7943117	7941119	c.7522C>T/c.14051T>C	{"RYR1": {"c.7522C>T": 1, "c.14051T>C": 1}}	\N
7943118	7941119	c.7292A>T/c.14497C>T	{"RYR1": {"c.7292A>T": 1, "c.14497C>T": 1}}	\N
7943119	7941119	c.7354C>T/c.14458G>T	{"RYR1": {"c.7354C>T": 1, "c.14458G>T": 1}}	\N
7943120	7941119	c.5890C>T/c.11708G>A	{"RYR1": {"c.5890C>T": 1, "c.11708G>A": 1}}	\N
7943121	7941119	c.5186T>G/c.14512C>G	{"RYR1": {"c.5186T>G": 1, "c.14512C>G": 1}}	\N
7943122	7941119	c.625G>A/c.6487C>T	{"RYR1": {"c.625G>A": 1, "c.6487C>T": 1}}	\N
7943123	7941119	c.3095G>A/c.6838G>A	{"RYR1": {"c.3095G>A": 1, "c.6838G>A": 1}}	\N
7943124	7941119	c.7090T>G/c.12121C>T	{"RYR1": {"c.7090T>G": 1, "c.12121C>T": 1}}	\N
7943125	7941119	c.12700G>C/c.14186A>C	{"RYR1": {"c.12700G>C": 1, "c.14186A>C": 1}}	\N
7943126	7941119	c.10252A>G/c.14918C>T	{"RYR1": {"c.10252A>G": 1, "c.14918C>T": 1}}	\N
7943127	7941119	c.7123G>A/c.11314C>T	{"RYR1": {"c.7123G>A": 1, "c.11314C>T": 1}}	\N
7943128	7941119	c.7354C>T/c.14458G>A	{"RYR1": {"c.7354C>T": 1, "c.14458G>A": 1}}	\N
7943129	7941119	c.742G>C/c.9848G>A	{"RYR1": {"c.742G>C": 1, "c.9848G>A": 1}}	\N
7943130	7941119	c.6743G>A/c.7361G>A	{"RYR1": {"c.6743G>A": 1, "c.7361G>A": 1}}	\N
7943131	7941119	c.487C>T/c.12848A>T	{"RYR1": {"c.487C>T": 1, "c.12848A>T": 1}}	\N
7943132	7941119	c.488G>T/c.7085A>G	{"RYR1": {"c.488G>T": 1, "c.7085A>G": 1}}	\N
7943133	7941119	c.5183C>T/c.14471T>C	{"RYR1": {"c.5183C>T": 1, "c.14471T>C": 1}}	\N
7943134	7941119	c.178G>T/c.1589G>A	{"RYR1": {"c.178G>T": 1, "c.1589G>A": 1}}	\N
7943135	7941119	c.1615T>G/c.7292A>T	{"RYR1": {"c.1615T>G": 1, "c.7292A>T": 1}}	\N
7943136	7941119	c.2122G>A/c.12700G>C	{"RYR1": {"c.2122G>A": 1, "c.12700G>C": 1}}	\N
7943137	7941119	c.528G>T/c.1202G>T	{"RYR1": {"c.528G>T": 1, "c.1202G>T": 1}}	\N
7943138	7941119	c.7360C>T/c.12115A>T	{"RYR1": {"c.7360C>T": 1, "c.12115A>T": 1}}	\N
7943139	7941119	c.10750G>C/c.11969G>T	{"RYR1": {"c.10750G>C": 1, "c.11969G>T": 1}}	\N
7943140	7941119	c.12149C>A/c.14814C>G	{"RYR1": {"c.12149C>A": 1, "c.14814C>G": 1}}	\N
7943141	7941119	c.7310C>T/c.9676G>C	{"RYR1": {"c.7310C>T": 1, "c.9676G>C": 1}}	\N
7943142	7941119	c.5341T>C/c.6838G>A	{"RYR1": {"c.5341T>C": 1, "c.6838G>A": 1}}	\N
7943143	7941119	c.97A>G/c.14201G>A	{"RYR1": {"c.97A>G": 1, "c.14201G>A": 1}}	\N
7943144	7941119	c.2122G>A/c.12700G>T	{"RYR1": {"c.2122G>A": 1, "c.12700G>T": 1}}	\N
7943145	7941119	c.1201C>T/c.5441T>A	{"RYR1": {"c.1201C>T": 1, "c.5441T>A": 1}}	\N
7943146	7941119	c.7282G>A/c.13505A>G	{"RYR1": {"c.7282G>A": 1, "c.13505A>G": 1}}	\N
7943147	7941119	c.7361G>A/c.10043G>A	{"RYR1": {"c.7361G>A": 1, "c.10043G>A": 1}}	\N
7943148	7941119	c.488G>T/c.7879G>A	{"RYR1": {"c.488G>T": 1, "c.7879G>A": 1}}	\N
7943149	7941119	c.7372C>T/c.9848G>A	{"RYR1": {"c.7372C>T": 1, "c.9848G>A": 1}}	\N
7943150	7941119	c.1144C>A/c.7007G>A	{"RYR1": {"c.1144C>A": 1, "c.7007G>A": 1}}	\N
7943151	7941119	c.2122G>A/c.7361G>A	{"RYR1": {"c.2122G>A": 1, "c.7361G>A": 1}}	\N
7943152	7941119	c.7048G>A/c.14186A>C	{"RYR1": {"c.7048G>A": 1, "c.14186A>C": 1}}	\N
7943153	7941119	c.9152G>A/c.12700G>C	{"RYR1": {"c.9152G>A": 1, "c.12700G>C": 1}}	\N
7943154	7941119	c.7358T>C/c.14782A>G	{"RYR1": {"c.7358T>C": 1, "c.14782A>G": 1}}	\N
7943155	7941119	c.1201C>T/c.6640G>A	{"RYR1": {"c.1201C>T": 1, "c.6640G>A": 1}}	\N
7943156	7941119	c.3166G>A/c.11315G>A	{"RYR1": {"c.3166G>A": 1, "c.11315G>A": 1}}	\N
7943157	7941119	c.5183C>T/c.12355A>T	{"RYR1": {"c.5183C>T": 1, "c.12355A>T": 1}}	\N
7943158	7941119	c.1565A>C/c.11813G>A	{"RYR1": {"c.1565A>C": 1, "c.11813G>A": 1}}	\N
7943159	7941119	c.7310C>T/c.9652G>A	{"RYR1": {"c.7310C>T": 1, "c.9652G>A": 1}}	\N
7943160	7941119	c.7360C>T/c.9152G>A	{"RYR1": {"c.7360C>T": 1, "c.9152G>A": 1}}	\N
7943161	7941119	c.3172G>A/c.7310C>T	{"RYR1": {"c.3172G>A": 1, "c.7310C>T": 1}}	\N
7943162	7941119	c.130C>T/c.11748T>G	{"RYR1": {"c.130C>T": 1, "c.11748T>G": 1}}	\N
7943163	7941119	c.2924G>A/c.6502G>A	{"RYR1": {"c.2924G>A": 1, "c.6502G>A": 1}}	\N
7943164	7941119	c.982C>T/c.7307G>A	{"RYR1": {"c.982C>T": 1, "c.7307G>A": 1}}	\N
7943165	7941119	c.6838G>A/c.14201G>A	{"RYR1": {"c.6838G>A": 1, "c.14201G>A": 1}}	\N
7943166	7941119	c.5890C>T/c.9310G>A	{"RYR1": {"c.5890C>T": 1, "c.9310G>A": 1}}	\N
7943167	7941119	c.7084G>A/c.7085A>G	{"RYR1": {"c.7084G>A": 1, "c.7085A>G": 1}}	\N
7943168	7941119	c.11947C>T/c.14210G>A	{"RYR1": {"c.11947C>T": 1, "c.14210G>A": 1}}	\N
7943169	7941119	c.529C>T/c.7073T>A	{"RYR1": {"c.529C>T": 1, "c.7073T>A": 1}}	\N
7943170	7941119	c.1202G>A/c.9268G>A	{"RYR1": {"c.1202G>A": 1, "c.9268G>A": 1}}	\N
7943171	7941119	c.7291G>T/c.15059G>C	{"RYR1": {"c.7291G>T": 1, "c.15059G>C": 1}}	\N
7943172	7941119	c.487C>T/c.9848G>A	{"RYR1": {"c.487C>T": 1, "c.9848G>A": 1}}	\N
7943173	7941119	c.7361G>A/c.14051T>C	{"RYR1": {"c.7361G>A": 1, "c.14051T>C": 1}}	\N
7943174	7941119	c.3172G>A/c.11315G>A	{"RYR1": {"c.3172G>A": 1, "c.11315G>A": 1}}	\N
7943175	7941119	c.1021G>A/c.14126C>T	{"RYR1": {"c.1021G>A": 1, "c.14126C>T": 1}}	\N
7943176	7941119	c.9152G>A/c.12700G>T	{"RYR1": {"c.9152G>A": 1, "c.12700G>T": 1}}	\N
7943177	7941119	c.6349G>C/c.12533G>T	{"RYR1": {"c.6349G>C": 1, "c.12533G>T": 1}}	\N
7943178	7941119	c.6757C>T/c.11708G>A	{"RYR1": {"c.6757C>T": 1, "c.11708G>A": 1}}	\N
7943179	7941119	c.6349G>C/c.6743G>A	{"RYR1": {"c.6349G>C": 1, "c.6743G>A": 1}}	\N
7943180	7941119	c.1422G>T/c.7007G>A	{"RYR1": {"c.1422G>T": 1, "c.7007G>A": 1}}	\N
7943181	7941119	c.2537C>T/c.8026C>T	{"RYR1": {"c.2537C>T": 1, "c.8026C>T": 1}}	\N
7943182	7941119	c.7291G>T/c.15060G>C	{"RYR1": {"c.7291G>T": 1, "c.15060G>C": 1}}	\N
7943183	7941119	c.8026C>T/c.12848A>T	{"RYR1": {"c.8026C>T": 1, "c.12848A>T": 1}}	\N
7943184	7941119	c.7073T>A/c.14209C>T	{"RYR1": {"c.7073T>A": 1, "c.14209C>T": 1}}	\N
7943185	7941119	c.1021G>C/c.13934G>A	{"RYR1": {"c.1021G>C": 1, "c.13934G>A": 1}}	\N
7943186	7941119	c.1589G>A/c.9676G>C	{"RYR1": {"c.1589G>A": 1, "c.9676G>C": 1}}	\N
7943187	7941119	c.212C>A/c.6617C>G	{"RYR1": {"c.212C>A": 1, "c.6617C>G": 1}}	\N
7943188	7941119	c.982C>T/c.1100G>T	{"RYR1": {"c.982C>T": 1, "c.1100G>T": 1}}	\N
7943189	7941119	c.7063C>T/c.12398A>G	{"RYR1": {"c.7063C>T": 1, "c.12398A>G": 1}}	\N
7943190	7941119	c.97A>G/c.2122G>A	{"RYR1": {"c.97A>G": 1, "c.2122G>A": 1}}	\N
7943191	7941119	c.13913G>A/c.14627A>G	{"RYR1": {"c.13913G>A": 1, "c.14627A>G": 1}}	\N
7943192	7941119	c.14210G>A/c.14364+1G>T	{"RYR1": {"c.14210G>A": 1, "c.14364+1G>T": 1}}	\N
7943193	7941119	c.7007G>A/c.14879T>A	{"RYR1": {"c.7007G>A": 1, "c.14879T>A": 1}}	\N
7943194	7941119	c.7523G>A/c.11314C>T	{"RYR1": {"c.7523G>A": 1, "c.11314C>T": 1}}	\N
7943195	7941119	c.6612C>G/c.7097C>G	{"RYR1": {"c.6612C>G": 1, "c.7097C>G": 1}}	\N
7943196	7941119	c.947G>T/c.1565A>G	{"RYR1": {"c.947G>T": 1, "c.1565A>G": 1}}	\N
7943197	7941119	c.1840C>T/c.6757C>T	{"RYR1": {"c.1840C>T": 1, "c.6757C>T": 1}}	\N
7943198	7941119	c.6612C>G/c.8638G>A	{"RYR1": {"c.6612C>G": 1, "c.8638G>A": 1}}	\N
7943199	7941119	c.103T>C/c.2122G>A	{"RYR1": {"c.103T>C": 1, "c.2122G>A": 1}}	\N
7943200	7941119	c.7073T>A/c.14497C>T	{"RYR1": {"c.7073T>A": 1, "c.14497C>T": 1}}	\N
7943201	7941119	c.131G>A/c.8026C>T	{"RYR1": {"c.131G>A": 1, "c.8026C>T": 1}}	\N
7943202	7941119	c.982C>T/c.3667G>A	{"RYR1": {"c.982C>T": 1, "c.3667G>A": 1}}	\N
7943203	7941119	c.1615T>C/c.7292A>T	{"RYR1": {"c.1615T>C": 1, "c.7292A>T": 1}}	\N
7943204	7941119	c.1453A>G/c.14803G>A	{"RYR1": {"c.1453A>G": 1, "c.14803G>A": 1}}	\N
7943205	7941119	c.488G>T/c.7018T>C	{"RYR1": {"c.488G>T": 1, "c.7018T>C": 1}}	\N
7943206	7941119	c.533A>G/c.6304G>C	{"RYR1": {"c.533A>G": 1, "c.6304G>C": 1}}	\N
7943207	7941119	c.6349G>C/c.10229C>A	{"RYR1": {"c.6349G>C": 1, "c.10229C>A": 1}}	\N
7943208	7941119	c.6617C>T/c.14449A>T	{"RYR1": {"c.6617C>T": 1, "c.14449A>T": 1}}	\N
7943209	7941119	c.1654C>T/c.7487C>T	{"RYR1": {"c.1654C>T": 1, "c.7487C>T": 1}}	\N
7943210	7941119	c.3527C>T/c.14918C>T	{"RYR1": {"c.3527C>T": 1, "c.14918C>T": 1}}	\N
7943211	7941119	c.1654C>T/c.2122G>A	{"RYR1": {"c.1654C>T": 1, "c.2122G>A": 1}}	\N
7943212	7941119	c.7007G>A/c.7097C>G	{"RYR1": {"c.7007G>A": 1, "c.7097C>G": 1}}	\N
7943213	7941119	c.1021G>C/c.14126C>T	{"RYR1": {"c.1021G>C": 1, "c.14126C>T": 1}}	\N
7943214	7941119	c.1201C>T/c.6304G>C	{"RYR1": {"c.1201C>T": 1, "c.6304G>C": 1}}	\N
7943215	7941119	c.3527C>T/c.6349G>C	{"RYR1": {"c.3527C>T": 1, "c.6349G>C": 1}}	\N
7943216	7941119	c.947G>T/c.1565A>C	{"RYR1": {"c.947G>T": 1, "c.1565A>C": 1}}	\N
7943217	7941119	c.6838G>A/c.14639T>C	{"RYR1": {"c.6838G>A": 1, "c.14639T>C": 1}}	\N
7943218	7941119	c.982C>T/c.1100G>A	{"RYR1": {"c.982C>T": 1, "c.1100G>A": 1}}	\N
7943219	7941119	c.212C>A/c.6617C>T	{"RYR1": {"c.212C>A": 1, "c.6617C>T": 1}}	\N
7943220	7941119	c.6302T>A/c.7043A>G	{"RYR1": {"c.6302T>A": 1, "c.7043A>G": 1}}	\N
7943221	7941119	c.6757C>T/c.9310G>A	{"RYR1": {"c.6757C>T": 1, "c.9310G>A": 1}}	\N
7943222	7941119	c.14209C>T/c.14270G>A	{"RYR1": {"c.14209C>T": 1, "c.14270G>A": 1}}	\N
7943223	7941119	c.1840C>T/c.13702C>G	{"RYR1": {"c.1840C>T": 1, "c.13702C>G": 1}}	\N
7943224	7941119	c.7076G>A/c.10252A>G	{"RYR1": {"c.7076G>A": 1, "c.10252A>G": 1}}	\N
7943225	7941119	c.463C>A/c.13934G>A	{"RYR1": {"c.463C>A": 1, "c.13934G>A": 1}}	\N
7943226	7941119	c.6628G>T/c.9152G>A	{"RYR1": {"c.6628G>T": 1, "c.9152G>A": 1}}	\N
7943227	7941119	c.7372C>T/c.12383C>T	{"RYR1": {"c.7372C>T": 1, "c.12383C>T": 1}}	\N
7943228	7941119	c.5186T>G/c.8026C>T	{"RYR1": {"c.5186T>G": 1, "c.8026C>T": 1}}	\N
7943229	7941119	c.38T>G/c.9758T>C	{"RYR1": {"c.38T>G": 1, "c.9758T>C": 1}}	\N
7943230	7941119	c.6349G>C/c.11132C>T	{"RYR1": {"c.6349G>C": 1, "c.11132C>T": 1}}	\N
7943231	7941119	c.6487C>T/c.12413T>C	{"RYR1": {"c.6487C>T": 1, "c.12413T>C": 1}}	\N
7943232	7941119	c.12689T>G/c.12700G>C	{"RYR1": {"c.12689T>G": 1, "c.12700G>C": 1}}	\N
7943233	7941119	c.1597C>T/c.11132C>T	{"RYR1": {"c.1597C>T": 1, "c.11132C>T": 1}}	\N
7943234	7941119	c.6304G>C/c.7076G>A	{"RYR1": {"c.6304G>C": 1, "c.7076G>A": 1}}	\N
7943235	7941119	c.38T>G/c.4400A>G	{"RYR1": {"c.38T>G": 1, "c.4400A>G": 1}}	\N
7943236	7941119	c.6304G>C/c.7304G>T	{"RYR1": {"c.6304G>C": 1, "c.7304G>T": 1}}	\N
7943237	7941119	c.6387C>G/c.9152G>A	{"RYR1": {"c.6387C>G": 1, "c.9152G>A": 1}}	\N
7943238	7941119	c.6617C>T/c.6710G>A	{"RYR1": {"c.6617C>T": 1, "c.6710G>A": 1}}	\N
7943239	7941119	c.529C>T/c.1475G>A	{"RYR1": {"c.529C>T": 1, "c.1475G>A": 1}}	\N
7943240	7941119	c.7042_7044delGAG/c.12064A>G	{"RYR1": {"c.12064A>G": 1, "c.7042_7044delGAG": 1}}	\N
7943241	7941119	c.488G>T/c.7099G>A	{"RYR1": {"c.488G>T": 1, "c.7099G>A": 1}}	\N
7943242	7941119	c.3166G>A/c.7361G>A	{"RYR1": {"c.3166G>A": 1, "c.7361G>A": 1}}	\N
7943243	7941119	c.7523G>A/c.14126C>T	{"RYR1": {"c.7523G>A": 1, "c.14126C>T": 1}}	\N
7943244	7941119	c.7361G>A/c.12848A>T	{"RYR1": {"c.7361G>A": 1, "c.12848A>T": 1}}	\N
7943245	7941119	c.479A>G/c.1615T>G	{"RYR1": {"c.479A>G": 1, "c.1615T>G": 1}}	\N
7943246	7941119	c.455C>A/c.7310C>T	{"RYR1": {"c.455C>A": 1, "c.7310C>T": 1}}	\N
7943247	7941119	c.6742C>T/c.14209C>T	{"RYR1": {"c.6742C>T": 1, "c.14209C>T": 1}}	\N
7943248	7941119	c.1565A>C/c.7355G>A	{"RYR1": {"c.1565A>C": 1, "c.7355G>A": 1}}	\N
7943249	7941119	c.8654C>G/c.14209C>T	{"RYR1": {"c.8654C>G": 1, "c.14209C>T": 1}}	\N
7943250	7941119	c.119G>C/c.1565A>C	{"RYR1": {"c.119G>C": 1, "c.1565A>C": 1}}	\N
7943251	7941119	c.1565A>C/c.7355G>C	{"RYR1": {"c.1565A>C": 1, "c.7355G>C": 1}}	\N
7943252	7941119	c.479A>G/c.1615T>C	{"RYR1": {"c.479A>G": 1, "c.1615T>C": 1}}	\N
7943253	7941119	c.6487C>T/c.14422_14423delinsAA	{"RYR1": {"c.6487C>T": 1, "c.14422_14423delinsAA": 1}}	\N
7943254	7941119	c.7360C>T/c.13990T>C	{"RYR1": {"c.7360C>T": 1, "c.13990T>C": 1}}	\N
7943255	7941119	c.9868G>A/c.11315G>A	{"RYR1": {"c.9868G>A": 1, "c.11315G>A": 1}}	\N
7943256	7941119	c.119G>C/c.1565A>G	{"RYR1": {"c.119G>C": 1, "c.1565A>G": 1}}	\N
7943257	7941119	c.6304G>C/c.7304G>A	{"RYR1": {"c.6304G>C": 1, "c.7304G>A": 1}}	\N
7943258	7941119	c.11416G>A/c.14918C>T	{"RYR1": {"c.11416G>A": 1, "c.14918C>T": 1}}	\N
7943259	7941119	c.6743G>A/c.7084G>A	{"RYR1": {"c.6743G>A": 1, "c.7084G>A": 1}}	\N
7943260	7941119	c.1411C>T/c.14209C>T	{"RYR1": {"c.1411C>T": 1, "c.14209C>T": 1}}	\N
7943261	7941119	c.7124G>C/c.11723A>T	{"RYR1": {"c.7124G>C": 1, "c.11723A>T": 1}}	\N
7943262	7941119	c.652G>A/c.1615T>C	{"RYR1": {"c.652G>A": 1, "c.1615T>C": 1}}	\N
7943263	7941119	c.7291G>A/c.8005G>A	{"RYR1": {"c.7291G>A": 1, "c.8005G>A": 1}}	\N
7943264	7941119	c.652G>A/c.1615T>G	{"RYR1": {"c.652G>A": 1, "c.1615T>G": 1}}	\N
7943265	7941119	c.103T>C/c.7307G>A	{"RYR1": {"c.103T>C": 1, "c.7307G>A": 1}}	\N
7943266	7941119	c.7310C>T/c.14449A>T	{"RYR1": {"c.7310C>T": 1, "c.14449A>T": 1}}	\N
7943267	7941119	c.6847A>C/c.7063C>T	{"RYR1": {"c.6847A>C": 1, "c.7063C>T": 1}}	\N
7943268	7941119	c.1021G>C/c.7085A>G	{"RYR1": {"c.1021G>C": 1, "c.7085A>G": 1}}	\N
7943269	7941119	c.7042_7044delGAG/c.9652G>A	{"RYR1": {"c.9652G>A": 1, "c.7042_7044delGAG": 1}}	\N
7943270	7941119	c.7060G>A/c.14581C>T	{"RYR1": {"c.7060G>A": 1, "c.14581C>T": 1}}	\N
7943271	7941119	c.6612C>G/c.11723A>T	{"RYR1": {"c.6612C>G": 1, "c.11723A>T": 1}}	\N
7943272	7941119	c.6743G>A/c.7300G>A	{"RYR1": {"c.6743G>A": 1, "c.7300G>A": 1}}	\N
7943273	7941119	c.1565A>C/c.6635T>A	{"RYR1": {"c.1565A>C": 1, "c.6635T>A": 1}}	\N
7943274	7941119	c.1841G>T/c.9635A>G	{"RYR1": {"c.1841G>T": 1, "c.9635A>G": 1}}	\N
7943275	7941119	c.7360C>T/c.14364+1G>T	{"RYR1": {"c.7360C>T": 1, "c.14364+1G>T": 1}}	\N
7943276	7941119	c.1411C>T/c.6349G>C	{"RYR1": {"c.1411C>T": 1, "c.6349G>C": 1}}	\N
7943277	7941119	c.7523G>A/c.7879G>A	{"RYR1": {"c.7523G>A": 1, "c.7879G>A": 1}}	\N
7943278	7941119	c.6743G>A/c.12700G>C	{"RYR1": {"c.6743G>A": 1, "c.12700G>C": 1}}	\N
7943279	7941119	c.11969G>T/c.14051T>C	{"RYR1": {"c.11969G>T": 1, "c.14051T>C": 1}}	\N
7943280	7941119	c.7032G>C/c.7063C>T	{"RYR1": {"c.7032G>C": 1, "c.7063C>T": 1}}	\N
7943281	7941119	c.8054C>T/c.11315G>A	{"RYR1": {"c.8054C>T": 1, "c.11315G>A": 1}}	\N
7943282	7941119	c.6743G>A/c.12700G>T	{"RYR1": {"c.6743G>A": 1, "c.12700G>T": 1}}	\N
7943283	7941119	c.533A>G/c.14051T>C	{"RYR1": {"c.533A>G": 1, "c.14051T>C": 1}}	\N
7943284	7941119	c.7291G>A/c.15059G>C	{"RYR1": {"c.7291G>A": 1, "c.15059G>C": 1}}	\N
7943285	7941119	c.6488G>T/c.8600T>A	{"RYR1": {"c.6488G>T": 1, "c.8600T>A": 1}}	\N
7943286	7941119	c.1615T>C/c.6388G>A	{"RYR1": {"c.1615T>C": 1, "c.6388G>A": 1}}	\N
7943287	7941119	c.5183C>T/c.7018T>C	{"RYR1": {"c.5183C>T": 1, "c.7018T>C": 1}}	\N
7943288	7941119	c.526G>A/c.6838G>A	{"RYR1": {"c.526G>A": 1, "c.6838G>A": 1}}	\N
7943289	7941119	c.212C>A/c.533A>G	{"RYR1": {"c.212C>A": 1, "c.533A>G": 1}}	\N
7943290	7941119	c.12700G>C/c.14680G>A	{"RYR1": {"c.12700G>C": 1, "c.14680G>A": 1}}	\N
7943291	7941119	c.1021G>A/c.7018T>C	{"RYR1": {"c.1021G>A": 1, "c.7018T>C": 1}}	\N
7943292	7941119	c.6628G>T/c.13990T>C	{"RYR1": {"c.6628G>T": 1, "c.13990T>C": 1}}	\N
7943293	7941119	c.1565A>G/c.7522C>G	{"RYR1": {"c.1565A>G": 1, "c.7522C>G": 1}}	\N
7943294	7941119	c.178G>A/c.7282G>A	{"RYR1": {"c.178G>A": 1, "c.7282G>A": 1}}	\N
7943295	7941119	c.463C>A/c.6640G>A	{"RYR1": {"c.463C>A": 1, "c.6640G>A": 1}}	\N
7943296	7941119	c.4400A>G/c.7373G>A	{"RYR1": {"c.4400A>G": 1, "c.7373G>A": 1}}	\N
7943297	7941119	c.1021G>C/c.7099G>A	{"RYR1": {"c.1021G>C": 1, "c.7099G>A": 1}}	\N
7943298	7941119	c.9850T>A/c.11708G>A	{"RYR1": {"c.9850T>A": 1, "c.11708G>A": 1}}	\N
7943299	7941119	c.3166G>C/c.11314C>T	{"RYR1": {"c.3166G>C": 1, "c.11314C>T": 1}}	\N
7943300	7941119	c.742G>A/c.12848A>T	{"RYR1": {"c.742G>A": 1, "c.12848A>T": 1}}	\N
7943301	7941119	c.1144C>A/c.7523G>A	{"RYR1": {"c.1144C>A": 1, "c.7523G>A": 1}}	\N
7943302	7941119	c.3656A>C/c.6349G>C	{"RYR1": {"c.3656A>C": 1, "c.6349G>C": 1}}	\N
7943303	7941119	c.14458G>T/c.14497C>T	{"RYR1": {"c.14458G>T": 1, "c.14497C>T": 1}}	\N
7943304	7941119	c.131G>A/c.14803G>A	{"RYR1": {"c.131G>A": 1, "c.14803G>A": 1}}	\N
7943305	7941119	c.1654C>T/c.7112A>G	{"RYR1": {"c.1654C>T": 1, "c.7112A>G": 1}}	\N
7943306	7941119	c.982C>T/c.7777C>G	{"RYR1": {"c.982C>T": 1, "c.7777C>G": 1}}	\N
7943307	7941119	c.7048G>A/c.7097C>G	{"RYR1": {"c.7048G>A": 1, "c.7097C>G": 1}}	\N
7943308	7941119	c.4400A>G/c.7373G>T	{"RYR1": {"c.4400A>G": 1, "c.7373G>T": 1}}	\N
7943309	7941119	c.3527C>T/c.11315G>A	{"RYR1": {"c.3527C>T": 1, "c.11315G>A": 1}}	\N
7943310	7941119	c.7060G>A/c.9676G>C	{"RYR1": {"c.7060G>A": 1, "c.9676G>C": 1}}	\N
7943311	7941119	c.6847A>C/c.7124G>C	{"RYR1": {"c.6847A>C": 1, "c.7124G>C": 1}}	\N
7943312	7941119	c.1565A>G/c.7355G>A	{"RYR1": {"c.1565A>G": 1, "c.7355G>A": 1}}	\N
7943313	7941119	c.1589G>A/c.12533G>T	{"RYR1": {"c.1589G>A": 1, "c.12533G>T": 1}}	\N
7943314	7941119	c.2122G>A/c.7300G>A	{"RYR1": {"c.2122G>A": 1, "c.7300G>A": 1}}	\N
7943315	7941119	c.1565A>G/c.7355G>C	{"RYR1": {"c.1565A>G": 1, "c.7355G>C": 1}}	\N
7943316	7941119	c.1021G>C/c.14471T>C	{"RYR1": {"c.1021G>C": 1, "c.14471T>C": 1}}	\N
7943317	7941119	c.6628G>T/c.12689T>G	{"RYR1": {"c.6628G>T": 1, "c.12689T>G": 1}}	\N
7943318	7941119	c.1024G>A/c.7043A>G	{"RYR1": {"c.1024G>A": 1, "c.7043A>G": 1}}	\N
7943319	7941119	c.7358T>C/c.14817C>A	{"RYR1": {"c.7358T>C": 1, "c.14817C>A": 1}}	\N
7943320	7941119	c.7879G>C/c.9797T>C	{"RYR1": {"c.7879G>C": 1, "c.9797T>C": 1}}	\N
7943321	7941119	c.11315G>A/c.11723A>T	{"RYR1": {"c.11315G>A": 1, "c.11723A>T": 1}}	\N
7943322	7941119	c.7282G>A/c.14693T>C	{"RYR1": {"c.7282G>A": 1, "c.14693T>C": 1}}	\N
7943323	7941119	c.6617C>T/c.14678G>A	{"RYR1": {"c.6617C>T": 1, "c.14678G>A": 1}}	\N
7943324	7941119	c.1654C>T/c.14639T>C	{"RYR1": {"c.1654C>T": 1, "c.14639T>C": 1}}	\N
7943325	7941119	c.7358T>C/c.7778G>A	{"RYR1": {"c.7358T>C": 1, "c.7778G>A": 1}}	\N
7943326	7941119	c.130C>T/c.12553G>A	{"RYR1": {"c.130C>T": 1, "c.12553G>A": 1}}	\N
7943327	7941119	c.487C>T/c.7317G>C	{"RYR1": {"c.487C>T": 1, "c.7317G>C": 1}}	\N
7943328	7941119	c.7036G>A/c.9676G>C	{"RYR1": {"c.7036G>A": 1, "c.9676G>C": 1}}	\N
7943329	7941119	c.6488G>T/c.14364+1G>T	{"RYR1": {"c.6488G>T": 1, "c.14364+1G>T": 1}}	\N
7943330	7941119	c.1841G>T/c.14270G>A	{"RYR1": {"c.1841G>T": 1, "c.14270G>A": 1}}	\N
7943331	7941119	c.1021G>C/c.7018T>C	{"RYR1": {"c.1021G>C": 1, "c.7018T>C": 1}}	\N
7943332	7941119	c.6349G>C/c.8729C>T	{"RYR1": {"c.6349G>C": 1, "c.8729C>T": 1}}	\N
7943333	7941119	c.1202G>T/c.1460T>C	{"RYR1": {"c.1202G>T": 1, "c.1460T>C": 1}}	\N
7943334	7941119	c.533A>G/c.12383C>T	{"RYR1": {"c.533A>G": 1, "c.12383C>T": 1}}	\N
7943335	7941119	c.7032G>C/c.7124G>C	{"RYR1": {"c.7032G>C": 1, "c.7124G>C": 1}}	\N
7943336	7941119	c.677T>A/c.11969G>T	{"RYR1": {"c.677T>A": 1, "c.11969G>T": 1}}	\N
7943337	7941119	c.13672C>T/c.14209C>T	{"RYR1": {"c.13672C>T": 1, "c.14209C>T": 1}}	\N
7943338	7941119	c.1597C>T/c.4400A>G	{"RYR1": {"c.1597C>T": 1, "c.4400A>G": 1}}	\N
7943339	7941119	c.3656A>C/c.14209C>T	{"RYR1": {"c.3656A>C": 1, "c.14209C>T": 1}}	\N
7943340	7941119	c.6628G>T/c.14364+1G>T	{"RYR1": {"c.6628G>T": 1, "c.14364+1G>T": 1}}	\N
7943341	7941119	c.488G>T/c.14126C>T	{"RYR1": {"c.488G>T": 1, "c.14126C>T": 1}}	\N
7943342	7941119	c.1021G>C/c.12355A>T	{"RYR1": {"c.1021G>C": 1, "c.12355A>T": 1}}	\N
7943343	7941119	c.7310C>T/c.12064A>G	{"RYR1": {"c.7310C>T": 1, "c.12064A>G": 1}}	\N
7943344	7941119	c.6349G>C/c.6742C>T	{"RYR1": {"c.6349G>C": 1, "c.6742C>T": 1}}	\N
7943345	7941119	c.652G>A/c.8026C>T	{"RYR1": {"c.652G>A": 1, "c.8026C>T": 1}}	\N
7943346	7941119	c.677T>A/c.1201C>T	{"RYR1": {"c.677T>A": 1, "c.1201C>T": 1}}	\N
7943347	7941119	c.7042_7044delGAG/c.9676G>C	{"RYR1": {"c.9676G>C": 1, "c.7042_7044delGAG": 1}}	\N
7943348	7941119	c.1201C>T/c.10042C>T	{"RYR1": {"c.1201C>T": 1, "c.10042C>T": 1}}	\N
7943349	7941119	c.14814C>G/c.14918C>T	{"RYR1": {"c.14814C>G": 1, "c.14918C>T": 1}}	\N
7943350	7941119	c.6617C>G/c.12533G>T	{"RYR1": {"c.6617C>G": 1, "c.12533G>T": 1}}	\N
7943351	7941119	c.3166G>C/c.14424C>A	{"RYR1": {"c.3166G>C": 1, "c.14424C>A": 1}}	\N
7943352	7941119	c.1615T>C/c.14364+1G>T	{"RYR1": {"c.1615T>C": 1, "c.14364+1G>T": 1}}	\N
7943353	7941119	c.178G>A/c.7063C>T	{"RYR1": {"c.178G>A": 1, "c.7063C>T": 1}}	\N
7943354	7941119	c.6548G>A/c.7310C>T	{"RYR1": {"c.6548G>A": 1, "c.7310C>T": 1}}	\N
7943355	7941119	c.463C>A/c.5441T>A	{"RYR1": {"c.463C>A": 1, "c.5441T>A": 1}}	\N
7943356	7941119	c.479A>G/c.14512C>G	{"RYR1": {"c.479A>G": 1, "c.14512C>G": 1}}	\N
7943357	7941119	c.6743G>A/c.7060G>A	{"RYR1": {"c.6743G>A": 1, "c.7060G>A": 1}}	\N
7943358	7941119	c.1565A>G/c.6635T>A	{"RYR1": {"c.1565A>G": 1, "c.6635T>A": 1}}	\N
7943359	7941119	c.2122G>A/c.7060G>A	{"RYR1": {"c.2122G>A": 1, "c.7060G>A": 1}}	\N
7943360	7941119	c.7063C>T/c.12242C>T	{"RYR1": {"c.7063C>T": 1, "c.12242C>T": 1}}	\N
7943361	7941119	c.6617C>T/c.9676G>C	{"RYR1": {"c.6617C>T": 1, "c.9676G>C": 1}}	\N
7943362	7941119	c.7304G>T/c.12532G>A	{"RYR1": {"c.7304G>T": 1, "c.12532G>A": 1}}	\N
7943363	7941119	c.6617C>T/c.14581C>T	{"RYR1": {"c.6617C>T": 1, "c.14581C>T": 1}}	\N
7943364	7941119	c.178G>A/c.14539G>C	{"RYR1": {"c.178G>A": 1, "c.14539G>C": 1}}	\N
7943365	7941119	c.6502G>A/c.11314C>T	{"RYR1": {"c.6502G>A": 1, "c.11314C>T": 1}}	\N
7943366	7941119	c.7385C>T/c.12700G>C	{"RYR1": {"c.7385C>T": 1, "c.12700G>C": 1}}	\N
7943367	7941119	c.1453A>G/c.5183C>T	{"RYR1": {"c.1453A>G": 1, "c.5183C>T": 1}}	\N
7943368	7941119	c.1597C>A/c.7043A>G	{"RYR1": {"c.1597C>A": 1, "c.7043A>G": 1}}	\N
7943369	7941119	c.3166G>A/c.7373G>A	{"RYR1": {"c.3166G>A": 1, "c.7373G>A": 1}}	\N
7943370	7941119	c.7089C>G/c.14477C>T	{"RYR1": {"c.7089C>G": 1, "c.14477C>T": 1}}	\N
7943371	7941119	c.4400A>G/c.7361G>A	{"RYR1": {"c.4400A>G": 1, "c.7361G>A": 1}}	\N
7943372	7941119	c.3166G>A/c.7373G>T	{"RYR1": {"c.3166G>A": 1, "c.7373G>T": 1}}	\N
7943373	7941119	c.178G>T/c.11969G>T	{"RYR1": {"c.178G>T": 1, "c.11969G>T": 1}}	\N
7943374	7941119	c.1475G>A/c.7354C>T	{"RYR1": {"c.1475G>A": 1, "c.7354C>T": 1}}	\N
7943375	7941119	c.680A>T/c.5183C>T	{"RYR1": {"c.680A>T": 1, "c.5183C>T": 1}}	\N
7943376	7941119	c.6544A>T/c.7523G>A	{"RYR1": {"c.6544A>T": 1, "c.7523G>A": 1}}	\N
7943377	7941119	c.8926C>T/c.11708G>A	{"RYR1": {"c.8926C>T": 1, "c.11708G>A": 1}}	\N
7943378	7941119	c.12689T>G/c.12700G>T	{"RYR1": {"c.12689T>G": 1, "c.12700G>T": 1}}	\N
7943379	7941119	c.7385C>T/c.12700G>T	{"RYR1": {"c.7385C>T": 1, "c.12700G>T": 1}}	\N
7943380	7941119	c.1021G>A/c.7085A>G	{"RYR1": {"c.1021G>A": 1, "c.7085A>G": 1}}	\N
7943381	7941119	c.178G>A/c.6387C>G	{"RYR1": {"c.178G>A": 1, "c.6387C>G": 1}}	\N
7943382	7941119	c.1024G>A/c.1630G>T	{"RYR1": {"c.1024G>A": 1, "c.1630G>T": 1}}	\N
7943383	7941119	c.463C>A/c.12355A>T	{"RYR1": {"c.463C>A": 1, "c.12355A>T": 1}}	\N
7943384	7941119	c.487C>T/c.8005G>A	{"RYR1": {"c.487C>T": 1, "c.8005G>A": 1}}	\N
7943385	7941119	c.7036G>A/c.14678G>A	{"RYR1": {"c.7036G>A": 1, "c.14678G>A": 1}}	\N
7943386	7941119	c.6349G>C/c.6478G>A	{"RYR1": {"c.6349G>C": 1, "c.6478G>A": 1}}	\N
7943387	7941119	c.6488G>T/c.11958C>G	{"RYR1": {"c.6488G>T": 1, "c.11958C>G": 1}}	\N
7943388	7941119	c.212C>A/c.9310G>A	{"RYR1": {"c.212C>A": 1, "c.9310G>A": 1}}	\N
7943389	7941119	c.7528T>C/c.12700G>T	{"RYR1": {"c.7528T>C": 1, "c.12700G>T": 1}}	\N
7943390	7941119	c.13505A>G/c.14545G>A	{"RYR1": {"c.13505A>G": 1, "c.14545G>A": 1}}	\N
7943391	7941119	c.1597C>T/c.4775C>T	{"RYR1": {"c.1597C>T": 1, "c.4775C>T": 1}}	\N
7943392	7941119	c.51_53del/c.3166G>C	{"RYR1": {"c.3166G>C": 1, "c.51_53del": 1}}	\N
7943393	7941119	c.529C>T/c.2654G>A	{"RYR1": {"c.529C>T": 1, "c.2654G>A": 1}}	\N
7943394	7941119	c.9652G>A/c.14627A>G	{"RYR1": {"c.9652G>A": 1, "c.14627A>G": 1}}	\N
7943395	7941119	c.6847A>C/c.14539G>C	{"RYR1": {"c.6847A>C": 1, "c.14539G>C": 1}}	\N
7943396	7941119	c.488G>T/c.496G>A	{"RYR1": {"c.488G>T": 1, "c.496G>A": 1}}	\N
7943397	7941119	c.8188G>C/c.14477C>T	{"RYR1": {"c.8188G>C": 1, "c.14477C>T": 1}}	\N
7943398	7941119	c.6349G>C/c.14582G>A	{"RYR1": {"c.6349G>C": 1, "c.14582G>A": 1}}	\N
7943399	7941119	c.742G>A/c.7317G>C	{"RYR1": {"c.742G>A": 1, "c.7317G>C": 1}}	\N
7943400	7941119	c.1021G>A/c.12355A>T	{"RYR1": {"c.1021G>A": 1, "c.12355A>T": 1}}	\N
7943401	7941119	c.6388G>A/c.7523G>A	{"RYR1": {"c.6388G>A": 1, "c.7523G>A": 1}}	\N
7943402	7941119	c.742G>C/c.15060G>C	{"RYR1": {"c.742G>C": 1, "c.15060G>C": 1}}	\N
7943403	7941119	c.97A>G/c.1024G>A	{"RYR1": {"c.97A>G": 1, "c.1024G>A": 1}}	\N
7943404	7941119	c.1201C>T/c.11813G>A	{"RYR1": {"c.1201C>T": 1, "c.11813G>A": 1}}	\N
7943405	7941119	c.1615T>G/c.11126C>T	{"RYR1": {"c.1615T>G": 1, "c.11126C>T": 1}}	\N
7943406	7941119	c.9310G>A/c.11518G>A	{"RYR1": {"c.9310G>A": 1, "c.11518G>A": 1}}	\N
7943407	7941119	c.8518C>T/c.14512C>G	{"RYR1": {"c.8518C>T": 1, "c.14512C>G": 1}}	\N
7943408	7941119	c.7048G>A/c.11723A>T	{"RYR1": {"c.7048G>A": 1, "c.11723A>T": 1}}	\N
7943409	7941119	c.7372C>T/c.11748T>G	{"RYR1": {"c.7372C>T": 1, "c.11748T>G": 1}}	\N
7943410	7941119	c.533A>G/c.11748T>G	{"RYR1": {"c.533A>G": 1, "c.11748T>G": 1}}	\N
7943411	7941119	c.1201C>T/c.7760A>G	{"RYR1": {"c.1201C>T": 1, "c.7760A>G": 1}}	\N
7943412	7941119	c.7060G>A/c.9652G>A	{"RYR1": {"c.7060G>A": 1, "c.9652G>A": 1}}	\N
7943413	7941119	c.6387C>G/c.6847A>C	{"RYR1": {"c.6387C>G": 1, "c.6847A>C": 1}}	\N
7943414	7941119	c.3127C>T/c.11315G>A	{"RYR1": {"c.3127C>T": 1, "c.11315G>A": 1}}	\N
7943415	7941119	c.7528T>C/c.12700G>C	{"RYR1": {"c.7528T>C": 1, "c.12700G>C": 1}}	\N
7943416	7941119	c.1597C>T/c.4763C>T	{"RYR1": {"c.1597C>T": 1, "c.4763C>T": 1}}	\N
7943417	7941119	c.1565A>C/c.6544A>T	{"RYR1": {"c.1565A>C": 1, "c.6544A>T": 1}}	\N
7943418	7941119	c.6640G>A/c.14477C>T	{"RYR1": {"c.6640G>A": 1, "c.14477C>T": 1}}	\N
7943419	7941119	c.9868G>A/c.14497C>T	{"RYR1": {"c.9868G>A": 1, "c.14497C>T": 1}}	\N
7943420	7941119	c.742G>C/c.15059G>C	{"RYR1": {"c.742G>C": 1, "c.15059G>C": 1}}	\N
7943421	7941119	c.1021G>A/c.7099G>A	{"RYR1": {"c.1021G>A": 1, "c.7099G>A": 1}}	\N
7943422	7941119	c.7310C>T/c.8518C>T	{"RYR1": {"c.7310C>T": 1, "c.8518C>T": 1}}	\N
7943423	7941119	c.14471T>C/c.14545G>A	{"RYR1": {"c.14471T>C": 1, "c.14545G>A": 1}}	\N
7943424	7941119	c.1615T>G/c.14364+1G>T	{"RYR1": {"c.1615T>G": 1, "c.14364+1G>T": 1}}	\N
7943425	7941119	c.2122G>A/c.7084G>A	{"RYR1": {"c.2122G>A": 1, "c.7084G>A": 1}}	\N
7943426	7941119	c.178G>A/c.7124G>C	{"RYR1": {"c.178G>A": 1, "c.7124G>C": 1}}	\N
7943427	7941119	c.5132A>G/c.12700G>T	{"RYR1": {"c.5132A>G": 1, "c.12700G>T": 1}}	\N
7943428	7941119	c.742G>C/c.12848A>T	{"RYR1": {"c.742G>C": 1, "c.12848A>T": 1}}	\N
7943429	7941119	c.7291G>A/c.7317G>C	{"RYR1": {"c.7291G>A": 1, "c.7317G>C": 1}}	\N
7943430	7941119	c.1021G>A/c.14471T>C	{"RYR1": {"c.1021G>A": 1, "c.14471T>C": 1}}	\N
7943431	7941119	c.119G>C/c.6628G>T	{"RYR1": {"c.119G>C": 1, "c.6628G>T": 1}}	\N
7943432	7941119	c.12149C>A/c.14197T>G	{"RYR1": {"c.12149C>A": 1, "c.14197T>G": 1}}	\N
7943433	7941119	c.6599C>T/c.6838G>A	{"RYR1": {"c.6599C>T": 1, "c.6838G>A": 1}}	\N
7943434	7941119	c.1840C>T/c.14524G>A	{"RYR1": {"c.1840C>T": 1, "c.14524G>A": 1}}	\N
7943435	7941119	c.463C>A/c.14471T>C	{"RYR1": {"c.463C>A": 1, "c.14471T>C": 1}}	\N
7943436	7941119	c.7372C>T/c.11947C>T	{"RYR1": {"c.7372C>T": 1, "c.11947C>T": 1}}	\N
7943437	7941119	c.6617C>G/c.14449A>T	{"RYR1": {"c.6617C>G": 1, "c.14449A>T": 1}}	\N
7943438	7941119	c.6304G>C/c.6628G>T	{"RYR1": {"c.6304G>C": 1, "c.6628G>T": 1}}	\N
7943439	7941119	c.533A>C/c.7042_7044delGAG	{"RYR1": {"c.533A>C": 1, "c.7042_7044delGAG": 1}}	\N
7943440	7941119	c.6502G>A/c.6599C>T	{"RYR1": {"c.6502G>A": 1, "c.6599C>T": 1}}	\N
7943441	7941119	c.742G>A/c.15060G>C	{"RYR1": {"c.742G>A": 1, "c.15060G>C": 1}}	\N
7943442	7941119	c.1422G>T/c.7523G>A	{"RYR1": {"c.1422G>T": 1, "c.7523G>A": 1}}	\N
7943443	7941119	c.488G>T/c.13934G>A	{"RYR1": {"c.488G>T": 1, "c.13934G>A": 1}}	\N
7943444	7941119	c.742G>C/c.7317G>C	{"RYR1": {"c.742G>C": 1, "c.7317G>C": 1}}	\N
7943445	7941119	c.3166G>C/c.14680G>A	{"RYR1": {"c.3166G>C": 1, "c.14680G>A": 1}}	\N
7943446	7941119	c.8026C>T/c.10043G>A	{"RYR1": {"c.8026C>T": 1, "c.10043G>A": 1}}	\N
7943447	7941119	c.1841G>T/c.5341T>C	{"RYR1": {"c.1841G>T": 1, "c.5341T>C": 1}}	\N
7943448	7941119	c.742G>C/c.8005G>A	{"RYR1": {"c.742G>C": 1, "c.8005G>A": 1}}	\N
7943449	7941119	c.7124G>C/c.8638G>A	{"RYR1": {"c.7124G>C": 1, "c.8638G>A": 1}}	\N
7943450	7941119	c.103T>C/c.8600T>A	{"RYR1": {"c.103T>C": 1, "c.8600T>A": 1}}	\N
7943451	7941119	c.7300G>A/c.12028G>A	{"RYR1": {"c.7300G>A": 1, "c.12028G>A": 1}}	\N
7943452	7941119	c.1202G>T/c.1453A>G	{"RYR1": {"c.1202G>T": 1, "c.1453A>G": 1}}	\N
7943453	7941119	c.6037A>C/c.14209C>T	{"RYR1": {"c.6037A>C": 1, "c.14209C>T": 1}}	\N
7943454	7941119	c.5132A>G/c.12700G>C	{"RYR1": {"c.5132A>G": 1, "c.12700G>C": 1}}	\N
7943455	7941119	c.38T>G/c.11132C>T	{"RYR1": {"c.38T>G": 1, "c.11132C>T": 1}}	\N
7943456	7941119	c.6487C>T/c.7528T>C	{"RYR1": {"c.6487C>T": 1, "c.7528T>C": 1}}	\N
7943457	7941119	c.3418C>T/c.6617C>G	{"RYR1": {"c.3418C>T": 1, "c.6617C>G": 1}}	\N
7943458	7941119	c.7042_7044delGAG/c.12533G>T	{"RYR1": {"c.12533G>T": 1, "c.7042_7044delGAG": 1}}	\N
7943459	7941119	c.529C>T/c.6548G>A	{"RYR1": {"c.529C>T": 1, "c.6548G>A": 1}}	\N
7943460	7941119	c.178G>T/c.7358T>C	{"RYR1": {"c.178G>T": 1, "c.7358T>C": 1}}	\N
7943461	7941119	c.97A>G/c.14825G>T	{"RYR1": {"c.97A>G": 1, "c.14825G>T": 1}}	\N
7943462	7941119	c.1630G>T/c.10750G>C	{"RYR1": {"c.1630G>T": 1, "c.10750G>C": 1}}	\N
7943463	7941119	c.103T>C/c.488G>A	{"RYR1": {"c.103T>C": 1, "c.488G>A": 1}}	\N
7943464	7941119	c.6488G>T/c.7307G>A	{"RYR1": {"c.6488G>T": 1, "c.7307G>A": 1}}	\N
7943465	7941119	c.7090T>G/c.12242C>T	{"RYR1": {"c.7090T>G": 1, "c.12242C>T": 1}}	\N
7943466	7941119	c.6617C>G/c.6710G>A	{"RYR1": {"c.6617C>G": 1, "c.6710G>A": 1}}	\N
7943467	7941119	c.6544A>T/c.7007G>A	{"RYR1": {"c.6544A>T": 1, "c.7007G>A": 1}}	\N
7943468	7941119	c.467G>A/c.487C>T	{"RYR1": {"c.467G>A": 1, "c.487C>T": 1}}	\N
7943469	7941119	c.6838G>A/c.11416G>A	{"RYR1": {"c.6838G>A": 1, "c.11416G>A": 1}}	\N
7943470	7941119	c.7291G>A/c.15060G>C	{"RYR1": {"c.7291G>A": 1, "c.15060G>C": 1}}	\N
7943471	7941119	c.11708G>A/c.12028G>A	{"RYR1": {"c.11708G>A": 1, "c.12028G>A": 1}}	\N
7943472	7941119	c.1565A>G/c.5441T>A	{"RYR1": {"c.1565A>G": 1, "c.5441T>A": 1}}	\N
7943473	7941119	c.641C>T/c.7522C>T	{"RYR1": {"c.641C>T": 1, "c.7522C>T": 1}}	\N
7943474	7941119	c.9310G>A/c.12121C>T	{"RYR1": {"c.9310G>A": 1, "c.12121C>T": 1}}	\N
7943475	7941119	c.3166G>C/c.5341T>C	{"RYR1": {"c.3166G>C": 1, "c.5341T>C": 1}}	\N
7943476	7941119	c.212C>A/c.7354C>T	{"RYR1": {"c.212C>A": 1, "c.7354C>T": 1}}	\N
7943477	7941119	c.3166G>C/c.14002C>T	{"RYR1": {"c.3166G>C": 1, "c.14002C>T": 1}}	\N
7943478	7941119	c.1565A>C/c.7210G>A	{"RYR1": {"c.1565A>C": 1, "c.7210G>A": 1}}	\N
7943479	7941119	c.11813G>A/c.14497C>T	{"RYR1": {"c.11813G>A": 1, "c.14497C>T": 1}}	\N
7943480	7941119	c.742G>A/c.8005G>A	{"RYR1": {"c.742G>A": 1, "c.8005G>A": 1}}	\N
7943481	7941119	c.6635T>A/c.7304G>A	{"RYR1": {"c.6635T>A": 1, "c.7304G>A": 1}}	\N
7943482	7941119	c.497A>G/c.7123G>A	{"RYR1": {"c.497A>G": 1, "c.7123G>A": 1}}	\N
7943483	7941119	c.3418C>T/c.6617C>T	{"RYR1": {"c.3418C>T": 1, "c.6617C>T": 1}}	\N
7943484	7941119	c.7124G>C/c.8926C>T	{"RYR1": {"c.7124G>C": 1, "c.8926C>T": 1}}	\N
7943485	7941119	c.1100G>T/c.7043A>G	{"RYR1": {"c.1100G>T": 1, "c.7043A>G": 1}}	\N
7943486	7941119	c.1201C>T/c.6037A>C	{"RYR1": {"c.1201C>T": 1, "c.6037A>C": 1}}	\N
7943487	7941119	c.14545G>A/c.14567C>G	{"RYR1": {"c.14545G>A": 1, "c.14567C>G": 1}}	\N
7943488	7941119	c.7084G>A/c.12028G>A	{"RYR1": {"c.7084G>A": 1, "c.12028G>A": 1}}	\N
7943489	7941119	c.463C>A/c.7099G>A	{"RYR1": {"c.463C>A": 1, "c.7099G>A": 1}}	\N
7943490	7941119	c.6635T>A/c.7304G>T	{"RYR1": {"c.6635T>A": 1, "c.7304G>T": 1}}	\N
7943491	7941119	c.103T>C/c.9356G>A	{"RYR1": {"c.103T>C": 1, "c.9356G>A": 1}}	\N
7943492	7941119	c.1589G>A/c.6710G>A	{"RYR1": {"c.1589G>A": 1, "c.6710G>A": 1}}	\N
7943493	7941119	c.2537C>T/c.14512C>G	{"RYR1": {"c.2537C>T": 1, "c.14512C>G": 1}}	\N
7943494	7941119	c.97A>G/c.8518C>T	{"RYR1": {"c.97A>G": 1, "c.8518C>T": 1}}	\N
7943495	7941119	c.8026C>T/c.14051T>C	{"RYR1": {"c.8026C>T": 1, "c.14051T>C": 1}}	\N
7943496	7941119	c.7373G>A/c.14471T>C	{"RYR1": {"c.7373G>A": 1, "c.14471T>C": 1}}	\N
7943497	7941119	c.6387C>G/c.11953T>C	{"RYR1": {"c.6387C>G": 1, "c.11953T>C": 1}}	\N
7943498	7941119	c.1100G>A/c.9310G>A	{"RYR1": {"c.1100G>A": 1, "c.9310G>A": 1}}	\N
7943499	7941119	c.6847A>C/c.7282G>A	{"RYR1": {"c.6847A>C": 1, "c.7282G>A": 1}}	\N
7943500	7941119	c.130C>T/c.7032G>C	{"RYR1": {"c.130C>T": 1, "c.7032G>C": 1}}	\N
7943501	7941119	c.6838G>A/c.13994_13995delTCinsCT	{"RYR1": {"c.6838G>A": 1, "c.13994_13995delTCinsCT": 1}}	\N
7943502	7941119	c.6617C>G/c.12064A>G	{"RYR1": {"c.6617C>G": 1, "c.12064A>G": 1}}	\N
7943503	7941119	c.119G>C/c.7304G>A	{"RYR1": {"c.119G>C": 1, "c.7304G>A": 1}}	\N
7943504	7941119	c.190T>C/c.1201C>T	{"RYR1": {"c.190T>C": 1, "c.1201C>T": 1}}	\N
7943505	7941119	c.14627A>G/c.14879T>A	{"RYR1": {"c.14627A>G": 1, "c.14879T>A": 1}}	\N
7943506	7941119	c.1453A>G/c.14477C>T	{"RYR1": {"c.1453A>G": 1, "c.14477C>T": 1}}	\N
7943507	7941119	c.677T>A/c.12149C>A	{"RYR1": {"c.677T>A": 1, "c.12149C>A": 1}}	\N
7943508	7941119	c.1841G>T/c.14424C>A	{"RYR1": {"c.1841G>T": 1, "c.14424C>A": 1}}	\N
7943509	7941119	c.1202G>T/c.9268G>A	{"RYR1": {"c.1202G>T": 1, "c.9268G>A": 1}}	\N
7943510	7941119	c.533A>G/c.6377G>A	{"RYR1": {"c.533A>G": 1, "c.6377G>A": 1}}	\N
7943511	7941119	c.6838G>A/c.7771C>T	{"RYR1": {"c.6838G>A": 1, "c.7771C>T": 1}}	\N
7943512	7941119	c.1202G>T/c.14558C>T	{"RYR1": {"c.1202G>T": 1, "c.14558C>T": 1}}	\N
7943513	7941119	c.6488G>C/c.9356G>A	{"RYR1": {"c.6488G>C": 1, "c.9356G>A": 1}}	\N
7943514	7941119	c.1202G>T/c.10750G>C	{"RYR1": {"c.1202G>T": 1, "c.10750G>C": 1}}	\N
7943515	7941119	c.6838G>A/c.7771C>G	{"RYR1": {"c.6838G>A": 1, "c.7771C>G": 1}}	\N
7943516	7941119	c.6302T>A/c.9310G>A	{"RYR1": {"c.6302T>A": 1, "c.9310G>A": 1}}	\N
7943517	7941119	c.6757C>T/c.7043A>G	{"RYR1": {"c.6757C>T": 1, "c.7043A>G": 1}}	\N
7943518	7941119	c.119G>C/c.7304G>T	{"RYR1": {"c.119G>C": 1, "c.7304G>T": 1}}	\N
7943519	7941119	c.1565A>C/c.7522C>G	{"RYR1": {"c.1565A>C": 1, "c.7522C>G": 1}}	\N
7943520	7941119	c.12383C>T/c.14209C>T	{"RYR1": {"c.12383C>T": 1, "c.14209C>T": 1}}	\N
7943521	7941119	c.7042_7044delGAG/c.7099G>A	{"RYR1": {"c.7099G>A": 1, "c.7042_7044delGAG": 1}}	\N
7943522	7941119	c.251C>T/c.1589G>A	{"RYR1": {"c.251C>T": 1, "c.1589G>A": 1}}	\N
7943523	7941119	c.479A>G/c.6349G>C	{"RYR1": {"c.479A>G": 1, "c.6349G>C": 1}}	\N
7943524	7941119	c.3166G>C/c.9868G>A	{"RYR1": {"c.3166G>C": 1, "c.9868G>A": 1}}	\N
7943525	7941119	c.5440A>G/c.7042_7044delGAG	{"RYR1": {"c.5440A>G": 1, "c.7042_7044delGAG": 1}}	\N
7943526	7941119	c.677T>A/c.6349G>C	{"RYR1": {"c.677T>A": 1, "c.6349G>C": 1}}	\N
7943527	7941119	c.7291G>A/c.7771C>T	{"RYR1": {"c.7291G>A": 1, "c.7771C>T": 1}}	\N
7943528	7941119	c.178G>T/c.529C>T	{"RYR1": {"c.178G>T": 1, "c.529C>T": 1}}	\N
7943529	7941119	c.487C>T/c.14364+1G>T	{"RYR1": {"c.487C>T": 1, "c.14364+1G>T": 1}}	\N
7943530	7941119	c.103T>C/c.1144C>A	{"RYR1": {"c.103T>C": 1, "c.1144C>A": 1}}	\N
7943531	7941119	c.5033A>G/c.6502G>A	{"RYR1": {"c.5033A>G": 1, "c.6502G>A": 1}}	\N
7943532	7941119	c.3095G>A/c.7084G>A	{"RYR1": {"c.3095G>A": 1, "c.7084G>A": 1}}	\N
7943533	7941119	c.6377G>A/c.14539G>C	{"RYR1": {"c.6377G>A": 1, "c.14539G>C": 1}}	\N
7943534	7941119	c.1460T>C/c.7007G>A	{"RYR1": {"c.1460T>C": 1, "c.7007G>A": 1}}	\N
7943535	7941119	c.7291G>A/c.7771C>G	{"RYR1": {"c.7291G>A": 1, "c.7771C>G": 1}}	\N
7943536	7941119	c.5132A>G/c.7373G>T	{"RYR1": {"c.5132A>G": 1, "c.7373G>T": 1}}	\N
7943537	7941119	c.12149C>A/c.12413T>C	{"RYR1": {"c.12149C>A": 1, "c.12413T>C": 1}}	\N
7943538	7941119	c.38T>G/c.12121C>T	{"RYR1": {"c.38T>G": 1, "c.12121C>T": 1}}	\N
7943539	7941119	c.487C>T/c.496G>A	{"RYR1": {"c.487C>T": 1, "c.496G>A": 1}}	\N
7943540	7941119	c.1201C>T/c.7210G>A	{"RYR1": {"c.1201C>T": 1, "c.7210G>A": 1}}	\N
7943541	7941119	c.7084G>A/c.8290G>A	{"RYR1": {"c.7084G>A": 1, "c.8290G>A": 1}}	\N
7943542	7941119	c.5183C>T/c.14639T>C	{"RYR1": {"c.5183C>T": 1, "c.14639T>C": 1}}	\N
7943543	7941119	c.7048G>A/c.11314C>T	{"RYR1": {"c.7048G>A": 1, "c.11314C>T": 1}}	\N
7943544	7941119	c.6599C>T/c.14545G>A	{"RYR1": {"c.6599C>T": 1, "c.14545G>A": 1}}	\N
7943545	7941119	c.7060G>A/c.7879G>A	{"RYR1": {"c.7060G>A": 1, "c.7879G>A": 1}}	\N
7943546	7941119	c.2924G>A/c.6487C>T	{"RYR1": {"c.2924G>A": 1, "c.6487C>T": 1}}	\N
7943547	7941119	c.5132A>G/c.7373G>A	{"RYR1": {"c.5132A>G": 1, "c.7373G>A": 1}}	\N
7943548	7941119	c.652G>A/c.1597C>T	{"RYR1": {"c.652G>A": 1, "c.1597C>T": 1}}	\N
7943549	7941119	c.6487C>T/c.6671G>A	{"RYR1": {"c.6487C>T": 1, "c.6671G>A": 1}}	\N
7943550	7941119	c.7124G>C/c.9850T>A	{"RYR1": {"c.7124G>C": 1, "c.9850T>A": 1}}	\N
7943551	7941119	c.1565A>C/c.13913G>A	{"RYR1": {"c.1565A>C": 1, "c.13913G>A": 1}}	\N
7943552	7941119	c.7073T>A/c.7084G>A	{"RYR1": {"c.7073T>A": 1, "c.7084G>A": 1}}	\N
7943553	7941119	c.6757C>T/c.7310C>T	{"RYR1": {"c.6757C>T": 1, "c.7310C>T": 1}}	\N
7943554	7941119	c.3656A>C/c.7300G>A	{"RYR1": {"c.3656A>C": 1, "c.7300G>A": 1}}	\N
7943555	7941119	c.6617C>G/c.13760C>T	{"RYR1": {"c.6617C>G": 1, "c.13760C>T": 1}}	\N
7943556	7941119	c.3095G>A/c.7060G>A	{"RYR1": {"c.3095G>A": 1, "c.7060G>A": 1}}	\N
7943557	7941119	c.5186T>G/c.7879G>C	{"RYR1": {"c.5186T>G": 1, "c.7879G>C": 1}}	\N
7943558	7941119	c.1565A>C/c.9758T>C	{"RYR1": {"c.1565A>C": 1, "c.9758T>C": 1}}	\N
7943559	7941119	c.1202G>A/c.1597C>A	{"RYR1": {"c.1202G>A": 1, "c.1597C>A": 1}}	\N
7943560	7941119	c.533A>C/c.7304G>T	{"RYR1": {"c.533A>C": 1, "c.7304G>T": 1}}	\N
7943561	7941119	c.1841G>T/c.14387A>G	{"RYR1": {"c.1841G>T": 1, "c.14387A>G": 1}}	\N
7943562	7941119	c.7528T>C/c.14627A>G	{"RYR1": {"c.7528T>C": 1, "c.14627A>G": 1}}	\N
7943563	7941119	c.11708G>A/c.12532G>A	{"RYR1": {"c.11708G>A": 1, "c.12532G>A": 1}}	\N
7943564	7941119	c.3166G>C/c.11518G>A	{"RYR1": {"c.3166G>C": 1, "c.11518G>A": 1}}	\N
7943565	7941119	c.487C>T/c.6640G>A	{"RYR1": {"c.487C>T": 1, "c.6640G>A": 1}}	\N
7943566	7941119	c.11723A>T/c.12700G>T	{"RYR1": {"c.11723A>T": 1, "c.12700G>T": 1}}	\N
7943567	7941119	c.1598G>A/c.6487C>T	{"RYR1": {"c.1598G>A": 1, "c.6487C>T": 1}}	\N
7943568	7941119	c.7879G>C/c.9758T>C	{"RYR1": {"c.7879G>C": 1, "c.9758T>C": 1}}	\N
7943569	7941119	c.7124G>C/c.14678G>A	{"RYR1": {"c.7124G>C": 1, "c.14678G>A": 1}}	\N
7943570	7941119	c.6635T>A/c.11969G>T	{"RYR1": {"c.6635T>A": 1, "c.11969G>T": 1}}	\N
7943571	7941119	c.130C>T/c.14818G>A	{"RYR1": {"c.130C>T": 1, "c.14818G>A": 1}}	\N
7943572	7941119	c.3418C>T/c.5183C>T	{"RYR1": {"c.3418C>T": 1, "c.5183C>T": 1}}	\N
7943573	7941119	c.7060G>A/c.10556C>T	{"RYR1": {"c.7060G>A": 1, "c.10556C>T": 1}}	\N
7943574	7941119	c.4763C>T/c.7523G>A	{"RYR1": {"c.4763C>T": 1, "c.7523G>A": 1}}	\N
7943575	7941119	c.7522C>T/c.13994_13995delTCinsCT	{"RYR1": {"c.7522C>T": 1, "c.13994_13995delTCinsCT": 1}}	\N
7943576	7941119	c.533A>C/c.7304G>A	{"RYR1": {"c.533A>C": 1, "c.7304G>A": 1}}	\N
7943577	7941119	c.38T>G/c.11953T>C	{"RYR1": {"c.38T>G": 1, "c.11953T>C": 1}}	\N
7943578	7941119	c.5183C>T/c.5441T>A	{"RYR1": {"c.5183C>T": 1, "c.5441T>A": 1}}	\N
7943579	7941119	c.1202G>A/c.14680G>A	{"RYR1": {"c.1202G>A": 1, "c.14680G>A": 1}}	\N
7943580	7941119	c.2654G>A/c.7523G>A	{"RYR1": {"c.2654G>A": 1, "c.7523G>A": 1}}	\N
7943581	7941119	c.7291G>A/c.9268G>A	{"RYR1": {"c.7291G>A": 1, "c.9268G>A": 1}}	\N
7943582	7941119	c.6502G>A/c.10556C>T	{"RYR1": {"c.6502G>A": 1, "c.10556C>T": 1}}	\N
7943583	7941119	c.5132A>G/c.7361G>A	{"RYR1": {"c.5132A>G": 1, "c.7361G>A": 1}}	\N
7943584	7941119	c.479A>G/c.14918C>T	{"RYR1": {"c.479A>G": 1, "c.14918C>T": 1}}	\N
7943585	7941119	c.5186T>G/c.7282G>A	{"RYR1": {"c.5186T>G": 1, "c.7282G>A": 1}}	\N
7943586	7941119	c.6628G>T/c.13994_13995delTCinsCT	{"RYR1": {"c.6628G>T": 1, "c.13994_13995delTCinsCT": 1}}	\N
7943587	7941119	c.7035C>A/c.14509C>G	{"RYR1": {"c.7035C>A": 1, "c.14509C>G": 1}}	\N
7943588	7941119	c.7304G>A/c.9635A>G	{"RYR1": {"c.7304G>A": 1, "c.9635A>G": 1}}	\N
7943589	7941119	c.7879G>C/c.13913G>A	{"RYR1": {"c.7879G>C": 1, "c.13913G>A": 1}}	\N
7943590	7941119	c.6037A>C/c.7879G>C	{"RYR1": {"c.6037A>C": 1, "c.7879G>C": 1}}	\N
7943591	7941119	c.11723A>T/c.12700G>C	{"RYR1": {"c.11723A>T": 1, "c.12700G>C": 1}}	\N
7943592	7941119	c.529C>T/c.7528T>C	{"RYR1": {"c.529C>T": 1, "c.7528T>C": 1}}	\N
7943593	7941119	c.1597C>T/c.6302T>A	{"RYR1": {"c.1597C>T": 1, "c.6302T>A": 1}}	\N
7943594	7941119	c.7354C>T/c.14782A>G	{"RYR1": {"c.7354C>T": 1, "c.14782A>G": 1}}	\N
7943595	7941119	c.7358T>C/c.12553G>A	{"RYR1": {"c.7358T>C": 1, "c.12553G>A": 1}}	\N
7943596	7941119	c.6838G>A/c.8926C>T	{"RYR1": {"c.6838G>A": 1, "c.8926C>T": 1}}	\N
7943597	7941119	c.7291G>A/c.12115A>T	{"RYR1": {"c.7291G>A": 1, "c.12115A>T": 1}}	\N
7943598	7941119	c.3166G>A/c.6612C>G	{"RYR1": {"c.3166G>A": 1, "c.6612C>G": 1}}	\N
7943599	7941119	c.130C>T/c.12115A>T	{"RYR1": {"c.130C>T": 1, "c.12115A>T": 1}}	\N
7943600	7941119	c.7085A>G/c.14627A>G	{"RYR1": {"c.7085A>G": 1, "c.14627A>G": 1}}	\N
7943601	7941119	c.982C>T/c.5440A>G	{"RYR1": {"c.982C>T": 1, "c.5440A>G": 1}}	\N
7943602	7941119	c.1475G>A/c.7042_7044delGAG	{"RYR1": {"c.1475G>A": 1, "c.7042_7044delGAG": 1}}	\N
7943603	7941119	c.1021G>A/c.9676G>C	{"RYR1": {"c.1021G>A": 1, "c.9676G>C": 1}}	\N
7943604	7941119	c.11416G>A/c.11969G>T	{"RYR1": {"c.11416G>A": 1, "c.11969G>T": 1}}	\N
7943605	7941119	c.7291G>T/c.8527T>C	{"RYR1": {"c.7291G>T": 1, "c.8527T>C": 1}}	\N
7943606	7941119	c.7292A>T/c.14627A>G	{"RYR1": {"c.7292A>T": 1, "c.14627A>G": 1}}	\N
7943607	7941119	c.7522C>T/c.14186A>C	{"RYR1": {"c.7522C>T": 1, "c.14186A>C": 1}}	\N
7943608	7941119	c.6488G>T/c.11813G>A	{"RYR1": {"c.6488G>T": 1, "c.11813G>A": 1}}	\N
7943609	7941119	c.7199A>G/c.14803G>A	{"RYR1": {"c.7199A>G": 1, "c.14803G>A": 1}}	\N
7943610	7941119	c.7304G>A/c.14818G>A	{"RYR1": {"c.7304G>A": 1, "c.14818G>A": 1}}	\N
7943611	7941119	c.8600T>A/c.9310G>A	{"RYR1": {"c.8600T>A": 1, "c.9310G>A": 1}}	\N
7943612	7941119	c.7048G>A/c.14825G>T	{"RYR1": {"c.7048G>A": 1, "c.14825G>T": 1}}	\N
7943613	7941119	c.7090T>G/c.10229C>A	{"RYR1": {"c.7090T>G": 1, "c.10229C>A": 1}}	\N
7943614	7941119	c.5033A>G/c.7291G>A	{"RYR1": {"c.5033A>G": 1, "c.7291G>A": 1}}	\N
7943615	7941119	c.5890C>T/c.6502G>A	{"RYR1": {"c.5890C>T": 1, "c.6502G>A": 1}}	\N
7943616	7941119	c.7036G>A/c.14270G>A	{"RYR1": {"c.7036G>A": 1, "c.14270G>A": 1}}	\N
7943617	7941119	c.6617C>T/c.8926C>T	{"RYR1": {"c.6617C>T": 1, "c.8926C>T": 1}}	\N
7943618	7941119	c.7042_7044delGAG/c.7085A>G	{"RYR1": {"c.7085A>G": 1, "c.7042_7044delGAG": 1}}	\N
7943619	7941119	c.3095G>A/c.7310C>T	{"RYR1": {"c.3095G>A": 1, "c.7310C>T": 1}}	\N
7943620	7941119	c.6710G>A/c.7076G>A	{"RYR1": {"c.6710G>A": 1, "c.7076G>A": 1}}	\N
7943621	7941119	c.7124G>C/c.14126C>T	{"RYR1": {"c.7124G>C": 1, "c.14126C>T": 1}}	\N
7943622	7941119	c.7354C>T/c.7778G>A	{"RYR1": {"c.7354C>T": 1, "c.7778G>A": 1}}	\N
7943623	7941119	c.497A>G/c.6612C>G	{"RYR1": {"c.497A>G": 1, "c.6612C>G": 1}}	\N
7943624	7941119	c.6742C>T/c.14477C>T	{"RYR1": {"c.6742C>T": 1, "c.14477C>T": 1}}	\N
7943625	7941119	c.6387C>G/c.7777C>G	{"RYR1": {"c.6387C>G": 1, "c.7777C>G": 1}}	\N
7943626	7941119	c.6617C>G/c.14582G>A	{"RYR1": {"c.6617C>G": 1, "c.14582G>A": 1}}	\N
7943627	7941119	c.1021G>C/c.12064A>G	{"RYR1": {"c.1021G>C": 1, "c.12064A>G": 1}}	\N
7943628	7941119	c.5033A>G/c.7291G>T	{"RYR1": {"c.5033A>G": 1, "c.7291G>T": 1}}	\N
7943629	7941119	c.1565A>G/c.13913G>A	{"RYR1": {"c.1565A>G": 1, "c.13913G>A": 1}}	\N
7943630	7941119	c.1840C>T/c.2996G>A	{"RYR1": {"c.1840C>T": 1, "c.2996G>A": 1}}	\N
7943631	7941119	c.6387C>G/c.7089C>G	{"RYR1": {"c.6387C>G": 1, "c.7089C>G": 1}}	\N
7943632	7941119	c.479A>G/c.7879G>C	{"RYR1": {"c.479A>G": 1, "c.7879G>C": 1}}	\N
7943633	7941119	c.7073T>A/c.12700G>C	{"RYR1": {"c.7073T>A": 1, "c.12700G>C": 1}}	\N
7943634	7941119	c.103T>C/c.5441T>A	{"RYR1": {"c.103T>C": 1, "c.5441T>A": 1}}	\N
7943635	7941119	c.38T>G/c.11748T>G	{"RYR1": {"c.38T>G": 1, "c.11748T>G": 1}}	\N
7943636	7941119	c.7304G>A/c.10237A>T	{"RYR1": {"c.7304G>A": 1, "c.10237A>T": 1}}	\N
7943637	7941119	c.1201C>T/c.13990T>C	{"RYR1": {"c.1201C>T": 1, "c.13990T>C": 1}}	\N
7943638	7941119	c.6757C>T/c.12700G>C	{"RYR1": {"c.6757C>T": 1, "c.12700G>C": 1}}	\N
7943639	7941119	c.3095G>A/c.12700G>T	{"RYR1": {"c.3095G>A": 1, "c.12700G>T": 1}}	\N
7943640	7941119	c.641C>T/c.982C>T	{"RYR1": {"c.641C>T": 1, "c.982C>T": 1}}	\N
7943641	7941119	c.1021G>C/c.9676G>C	{"RYR1": {"c.1021G>C": 1, "c.9676G>C": 1}}	\N
7943642	7941119	c.3656A>C/c.7361G>A	{"RYR1": {"c.3656A>C": 1, "c.7361G>A": 1}}	\N
7943643	7941119	c.1201C>T/c.14825G>T	{"RYR1": {"c.1201C>T": 1, "c.14825G>T": 1}}	\N
7943644	7941119	c.7073T>A/c.12700G>T	{"RYR1": {"c.7073T>A": 1, "c.12700G>T": 1}}	\N
7943645	7941119	c.51_53del/c.7036G>A	{"RYR1": {"c.7036G>A": 1, "c.51_53del": 1}}	\N
7943646	7941119	c.7036G>A/c.9268G>A	{"RYR1": {"c.7036G>A": 1, "c.9268G>A": 1}}	\N
7943647	7941119	c.7771C>G/c.14539G>C	{"RYR1": {"c.7771C>G": 1, "c.14539G>C": 1}}	\N
7943648	7941119	c.533A>G/c.13913G>A	{"RYR1": {"c.533A>G": 1, "c.13913G>A": 1}}	\N
7943649	7941119	c.7007G>A/c.13934G>A	{"RYR1": {"c.7007G>A": 1, "c.13934G>A": 1}}	\N
7943650	7941119	c.6757C>T/c.7084G>A	{"RYR1": {"c.6757C>T": 1, "c.7084G>A": 1}}	\N
7943651	7941119	c.1202G>T/c.2996G>A	{"RYR1": {"c.1202G>T": 1, "c.2996G>A": 1}}	\N
7943652	7941119	c.9152G>A/c.14627A>G	{"RYR1": {"c.9152G>A": 1, "c.14627A>G": 1}}	\N
7943653	7941119	c.6037A>C/c.14918C>T	{"RYR1": {"c.6037A>C": 1, "c.14918C>T": 1}}	\N
7943654	7941119	c.251C>T/c.14210G>A	{"RYR1": {"c.251C>T": 1, "c.14210G>A": 1}}	\N
7943655	7941119	c.6635T>A/c.14477C>T	{"RYR1": {"c.6635T>A": 1, "c.14477C>T": 1}}	\N
7943656	7941119	c.7354C>T/c.8654C>G	{"RYR1": {"c.7354C>T": 1, "c.8654C>G": 1}}	\N
7943657	7941119	c.1841G>T/c.6710G>A	{"RYR1": {"c.1841G>T": 1, "c.6710G>A": 1}}	\N
7943658	7941119	c.7291G>T/c.8654C>G	{"RYR1": {"c.7291G>T": 1, "c.8654C>G": 1}}	\N
7943659	7941119	c.6757C>T/c.12700G>T	{"RYR1": {"c.6757C>T": 1, "c.12700G>T": 1}}	\N
7943660	7941119	c.7304G>A/c.11120G>T	{"RYR1": {"c.7304G>A": 1, "c.11120G>T": 1}}	\N
7943661	7941119	c.1021G>A/c.12064A>G	{"RYR1": {"c.1021G>A": 1, "c.12064A>G": 1}}	\N
7943662	7941119	c.7060G>A/c.14002C>T	{"RYR1": {"c.7060G>A": 1, "c.14002C>T": 1}}	\N
7943663	7941119	c.103T>C/c.4400A>G	{"RYR1": {"c.103T>C": 1, "c.4400A>G": 1}}	\N
7943664	7941119	c.7063C>T/c.11086G>C	{"RYR1": {"c.7063C>T": 1, "c.11086G>C": 1}}	\N
7943665	7941119	c.463C>A/c.13994_13995delTCinsCT	{"RYR1": {"c.463C>A": 1, "c.13994_13995delTCinsCT": 1}}	\N
7943666	7941119	c.3166G>C/c.9652G>A	{"RYR1": {"c.3166G>C": 1, "c.9652G>A": 1}}	\N
7943667	7941119	c.6377G>A/c.11708G>A	{"RYR1": {"c.6377G>A": 1, "c.11708G>A": 1}}	\N
7943668	7941119	c.12242C>T/c.14539G>C	{"RYR1": {"c.12242C>T": 1, "c.14539G>C": 1}}	\N
7943669	7941119	c.7035C>A/c.14449A>T	{"RYR1": {"c.7035C>A": 1, "c.14449A>T": 1}}	\N
7943670	7941119	c.3095G>A/c.12700G>C	{"RYR1": {"c.3095G>A": 1, "c.12700G>C": 1}}	\N
7943671	7941119	c.6488G>A/c.9758T>C	{"RYR1": {"c.6488G>A": 1, "c.9758T>C": 1}}	\N
7943672	7941119	c.6612C>G/c.13918A>G	{"RYR1": {"c.6612C>G": 1, "c.13918A>G": 1}}	\N
7943673	7941119	c.1654C>T/c.4400A>G	{"RYR1": {"c.1654C>T": 1, "c.4400A>G": 1}}	\N
7943674	7941119	c.1841G>T/c.10556C>T	{"RYR1": {"c.1841G>T": 1, "c.10556C>T": 1}}	\N
7943675	7941119	c.5186T>G/c.6349G>C	{"RYR1": {"c.5186T>G": 1, "c.6349G>C": 1}}	\N
7943676	7941119	c.7354C>T/c.8527T>C	{"RYR1": {"c.7354C>T": 1, "c.8527T>C": 1}}	\N
7943677	7941119	c.14387A>G/c.14918C>T	{"RYR1": {"c.14387A>G": 1, "c.14918C>T": 1}}	\N
7943678	7941119	c.6488G>C/c.13913G>A	{"RYR1": {"c.6488G>C": 1, "c.13913G>A": 1}}	\N
7943679	7941119	c.7373G>A/c.9152G>A	{"RYR1": {"c.7373G>A": 1, "c.9152G>A": 1}}	\N
7943680	7941119	c.4747C>T/c.7310C>T	{"RYR1": {"c.4747C>T": 1, "c.7310C>T": 1}}	\N
7943681	7941119	c.119G>C/c.7124G>C	{"RYR1": {"c.119G>C": 1, "c.7124G>C": 1}}	\N
7943682	7941119	c.1100G>A/c.6502G>A	{"RYR1": {"c.1100G>A": 1, "c.6502G>A": 1}}	\N
7943683	7941119	c.6617C>T/c.14582G>A	{"RYR1": {"c.6617C>T": 1, "c.14582G>A": 1}}	\N
7943684	7941119	c.7043A>G/c.13505A>G	{"RYR1": {"c.7043A>G": 1, "c.13505A>G": 1}}	\N
7943685	7941119	c.7522C>G/c.14209C>T	{"RYR1": {"c.7522C>G": 1, "c.14209C>T": 1}}	\N
7943686	7941119	c.5440A>G/c.14539G>C	{"RYR1": {"c.5440A>G": 1, "c.14539G>C": 1}}	\N
7943687	7941119	c.7317G>C/c.12700G>T	{"RYR1": {"c.7317G>C": 1, "c.12700G>T": 1}}	\N
7943688	7941119	c.8026C>T/c.13702C>G	{"RYR1": {"c.8026C>T": 1, "c.13702C>G": 1}}	\N
7943689	7941119	c.12700G>C/c.14825G>T	{"RYR1": {"c.12700G>C": 1, "c.14825G>T": 1}}	\N
7943690	7941119	c.6488G>T/c.11416G>A	{"RYR1": {"c.6488G>T": 1, "c.11416G>A": 1}}	\N
7943691	7941119	c.7060G>A/c.14387A>G	{"RYR1": {"c.7060G>A": 1, "c.14387A>G": 1}}	\N
7943692	7941119	c.103T>C/c.11947C>T	{"RYR1": {"c.103T>C": 1, "c.11947C>T": 1}}	\N
7943693	7941119	c.488G>T/c.11126C>T	{"RYR1": {"c.488G>T": 1, "c.11126C>T": 1}}	\N
7943694	7941119	c.1021G>C/c.10750G>C	{"RYR1": {"c.1021G>C": 1, "c.10750G>C": 1}}	\N
7943695	7941119	c.7317G>C/c.12700G>C	{"RYR1": {"c.7317G>C": 1, "c.12700G>C": 1}}	\N
7943696	7941119	c.6377G>A/c.9310G>A	{"RYR1": {"c.6377G>A": 1, "c.9310G>A": 1}}	\N
7943697	7941119	c.1615T>C/c.7355G>C	{"RYR1": {"c.1615T>C": 1, "c.7355G>C": 1}}	\N
7943698	7941119	c.5024T>C/c.6487C>T	{"RYR1": {"c.5024T>C": 1, "c.6487C>T": 1}}	\N
7943699	7941119	c.4747C>T/c.7084G>A	{"RYR1": {"c.4747C>T": 1, "c.7084G>A": 1}}	\N
7943700	7941119	c.7292A>T/c.12149C>A	{"RYR1": {"c.7292A>T": 1, "c.12149C>A": 1}}	\N
7943701	7941119	c.6388G>A/c.6617C>T	{"RYR1": {"c.6388G>A": 1, "c.6617C>T": 1}}	\N
7943702	7941119	c.6488G>T/c.7073T>A	{"RYR1": {"c.6488G>T": 1, "c.7073T>A": 1}}	\N
7943703	7941119	c.1615T>C/c.7355G>A	{"RYR1": {"c.1615T>C": 1, "c.7355G>A": 1}}	\N
7943704	7941119	c.7075C>T/c.7291G>A	{"RYR1": {"c.7075C>T": 1, "c.7291G>A": 1}}	\N
7943705	7941119	c.463C>A/c.12848A>T	{"RYR1": {"c.463C>A": 1, "c.12848A>T": 1}}	\N
7943706	7941119	c.6742C>T/c.7063C>T	{"RYR1": {"c.6742C>T": 1, "c.7063C>T": 1}}	\N
7943707	7941119	c.6488G>A/c.13913G>A	{"RYR1": {"c.6488G>A": 1, "c.13913G>A": 1}}	\N
7943708	7941119	c.6478G>A/c.7310C>T	{"RYR1": {"c.6478G>A": 1, "c.7310C>T": 1}}	\N
7943709	7941119	c.9797T>C/c.11708G>A	{"RYR1": {"c.9797T>C": 1, "c.11708G>A": 1}}	\N
7943710	7941119	c.3527C>T/c.12700G>C	{"RYR1": {"c.3527C>T": 1, "c.12700G>C": 1}}	\N
7943711	7941119	c.992_994dup/c.6387C>G	{"RYR1": {"c.6387C>G": 1, "c.992_994dup": 1}}	\N
7943712	7941119	c.130C>T/c.8005G>A	{"RYR1": {"c.130C>T": 1, "c.8005G>A": 1}}	\N
7943713	7941119	c.1411C>T/c.7360C>T	{"RYR1": {"c.1411C>T": 1, "c.7360C>T": 1}}	\N
7943714	7941119	c.1202G>A/c.3095G>A	{"RYR1": {"c.1202G>A": 1, "c.3095G>A": 1}}	\N
7943715	7941119	c.7360C>T/c.12848A>T	{"RYR1": {"c.7360C>T": 1, "c.12848A>T": 1}}	\N
7943716	7941119	c.8600T>A/c.11708G>A	{"RYR1": {"c.8600T>A": 1, "c.11708G>A": 1}}	\N
7943717	7941119	c.1144C>A/c.7042_7044delGAG	{"RYR1": {"c.1144C>A": 1, "c.7042_7044delGAG": 1}}	\N
7943718	7941119	c.7523G>A/c.8290G>A	{"RYR1": {"c.7523G>A": 1, "c.8290G>A": 1}}	\N
7943719	7941119	c.6612C>G/c.10229C>A	{"RYR1": {"c.6612C>G": 1, "c.10229C>A": 1}}	\N
7943720	7941119	c.11969G>T/c.14879T>A	{"RYR1": {"c.11969G>T": 1, "c.14879T>A": 1}}	\N
7943721	7941119	c.7043A>G/c.7307G>A	{"RYR1": {"c.7043A>G": 1, "c.7307G>A": 1}}	\N
7943722	7941119	c.3527C>T/c.12700G>T	{"RYR1": {"c.3527C>T": 1, "c.12700G>T": 1}}	\N
7943723	7941119	c.97A>G/c.12115A>T	{"RYR1": {"c.97A>G": 1, "c.12115A>T": 1}}	\N
7943724	7941119	c.6617C>G/c.14186A>C	{"RYR1": {"c.6617C>G": 1, "c.14186A>C": 1}}	\N
7943725	7941119	c.677T>A/c.7879G>C	{"RYR1": {"c.677T>A": 1, "c.7879G>C": 1}}	\N
7943726	7941119	c.6387C>G/c.14197T>G	{"RYR1": {"c.6387C>G": 1, "c.14197T>G": 1}}	\N
7943727	7941119	c.7043A>G/c.11518G>A	{"RYR1": {"c.7043A>G": 1, "c.11518G>A": 1}}	\N
7943728	7941119	c.8600T>A/c.14539G>C	{"RYR1": {"c.8600T>A": 1, "c.14539G>C": 1}}	\N
7943729	7941119	c.1202G>T/c.7075C>T	{"RYR1": {"c.1202G>T": 1, "c.7075C>T": 1}}	\N
7943730	7941119	c.1021G>A/c.10750G>C	{"RYR1": {"c.1021G>A": 1, "c.10750G>C": 1}}	\N
7943731	7941119	c.7358T>C/c.13760C>T	{"RYR1": {"c.7358T>C": 1, "c.13760C>T": 1}}	\N
7943732	7941119	c.7075C>T/c.7291G>T	{"RYR1": {"c.7075C>T": 1, "c.7291G>T": 1}}	\N
7943733	7941119	c.1411C>T/c.7048G>A	{"RYR1": {"c.1411C>T": 1, "c.7048G>A": 1}}	\N
7943734	7941119	c.8026C>T/c.14814C>G	{"RYR1": {"c.8026C>T": 1, "c.14814C>G": 1}}	\N
7943735	7941119	c.7373G>T/c.9356G>A	{"RYR1": {"c.7373G>T": 1, "c.9356G>A": 1}}	\N
7943736	7941119	c.130C>T/c.11120G>T	{"RYR1": {"c.130C>T": 1, "c.11120G>T": 1}}	\N
7943737	7941119	c.529C>T/c.6743G>A	{"RYR1": {"c.529C>T": 1, "c.6743G>A": 1}}	\N
7943738	7941119	c.6502G>A/c.14002C>T	{"RYR1": {"c.6502G>A": 1, "c.14002C>T": 1}}	\N
7943739	7941119	c.130C>T/c.15060G>C	{"RYR1": {"c.130C>T": 1, "c.15060G>C": 1}}	\N
7943740	7941119	c.1201C>T/c.7089C>G	{"RYR1": {"c.1201C>T": 1, "c.7089C>G": 1}}	\N
7943741	7941119	c.3166G>C/c.10556C>T	{"RYR1": {"c.3166G>C": 1, "c.10556C>T": 1}}	\N
7943742	7941119	c.7042_7044delGAG/c.9635A>G	{"RYR1": {"c.9635A>G": 1, "c.7042_7044delGAG": 1}}	\N
7943743	7941119	c.212C>A/c.7043A>G	{"RYR1": {"c.212C>A": 1, "c.7043A>G": 1}}	\N
7943744	7941119	c.1597C>T/c.13913G>A	{"RYR1": {"c.1597C>T": 1, "c.13913G>A": 1}}	\N
7943745	7941119	c.6487C>T/c.7522C>G	{"RYR1": {"c.6487C>T": 1, "c.7522C>G": 1}}	\N
7943746	7941119	c.131G>A/c.7123G>A	{"RYR1": {"c.131G>A": 1, "c.7123G>A": 1}}	\N
7943747	7941119	c.5132A>G/c.7043A>G	{"RYR1": {"c.5132A>G": 1, "c.7043A>G": 1}}	\N
7943748	7941119	c.3127C>T/c.7361G>A	{"RYR1": {"c.3127C>T": 1, "c.7361G>A": 1}}	\N
7943749	7941119	c.5441T>A/c.14545G>A	{"RYR1": {"c.5441T>A": 1, "c.14545G>A": 1}}	\N
7943750	7941119	c.529C>T/c.13505A>G	{"RYR1": {"c.529C>T": 1, "c.13505A>G": 1}}	\N
7943751	7941119	c.8527T>C/c.14512C>G	{"RYR1": {"c.8527T>C": 1, "c.14512C>G": 1}}	\N
7943752	7941119	c.8026C>T/c.14126C>T	{"RYR1": {"c.8026C>T": 1, "c.14126C>T": 1}}	\N
7943753	7941119	c.10556C>T/c.11708G>A	{"RYR1": {"c.10556C>T": 1, "c.11708G>A": 1}}	\N
7943754	7941119	c.12532G>A/c.14512C>G	{"RYR1": {"c.12532G>A": 1, "c.14512C>G": 1}}	\N
7943755	7941119	c.5183C>T/c.10556C>T	{"RYR1": {"c.5183C>T": 1, "c.10556C>T": 1}}	\N
7943756	7941119	c.6502G>A/c.11518G>A	{"RYR1": {"c.6502G>A": 1, "c.11518G>A": 1}}	\N
7943757	7941119	c.497A>G/c.7304G>A	{"RYR1": {"c.497A>G": 1, "c.7304G>A": 1}}	\N
7943758	7941119	c.946C>T/c.6488G>T	{"RYR1": {"c.946C>T": 1, "c.6488G>T": 1}}	\N
7943759	7941119	c.3166G>A/c.6349G>C	{"RYR1": {"c.3166G>A": 1, "c.6349G>C": 1}}	\N
7943760	7941119	c.1201C>T/c.9848G>A	{"RYR1": {"c.1201C>T": 1, "c.9848G>A": 1}}	\N
7943761	7941119	c.6487C>T/c.9649T>C	{"RYR1": {"c.6487C>T": 1, "c.9649T>C": 1}}	\N
7943762	7941119	c.487C>T/c.7112A>G	{"RYR1": {"c.487C>T": 1, "c.7112A>G": 1}}	\N
7943763	7941119	c.251C>T/c.7048G>A	{"RYR1": {"c.251C>T": 1, "c.7048G>A": 1}}	\N
7943764	7941119	c.12398A>G/c.12700G>T	{"RYR1": {"c.12398A>G": 1, "c.12700G>T": 1}}	\N
7943765	7941119	c.10750G>C/c.14512C>G	{"RYR1": {"c.10750G>C": 1, "c.14512C>G": 1}}	\N
7943766	7941119	c.7354C>T/c.14817C>A	{"RYR1": {"c.7354C>T": 1, "c.14817C>A": 1}}	\N
7943767	7941119	c.497A>G/c.7304G>T	{"RYR1": {"c.497A>G": 1, "c.7304G>T": 1}}	\N
7943768	7941119	c.982C>T/c.11748T>G	{"RYR1": {"c.982C>T": 1, "c.11748T>G": 1}}	\N
7943769	7941119	c.7060G>A/c.13760C>T	{"RYR1": {"c.7060G>A": 1, "c.13760C>T": 1}}	\N
7943770	7941119	c.1021G>C/c.9652G>A	{"RYR1": {"c.1021G>C": 1, "c.9652G>A": 1}}	\N
7943771	7941119	c.1475G>A/c.11708G>A	{"RYR1": {"c.1475G>A": 1, "c.11708G>A": 1}}	\N
7943772	7941119	c.1840C>T/c.11723A>T	{"RYR1": {"c.1840C>T": 1, "c.11723A>T": 1}}	\N
7943773	7941119	c.130C>T/c.15059G>C	{"RYR1": {"c.130C>T": 1, "c.15059G>C": 1}}	\N
7943774	7941119	c.7035C>A/c.8198G>A	{"RYR1": {"c.7035C>A": 1, "c.8198G>A": 1}}	\N
7943775	7941119	c.6488G>C/c.7307G>A	{"RYR1": {"c.6488G>C": 1, "c.7307G>A": 1}}	\N
7943776	7941119	c.1615T>G/c.7355G>A	{"RYR1": {"c.1615T>G": 1, "c.7355G>A": 1}}	\N
7943777	7941119	c.1654C>T/c.7307G>A	{"RYR1": {"c.1654C>T": 1, "c.7307G>A": 1}}	\N
7943778	7941119	c.7084G>A/c.14825G>T	{"RYR1": {"c.7084G>A": 1, "c.14825G>T": 1}}	\N
7943779	7941119	c.1615T>G/c.7355G>C	{"RYR1": {"c.1615T>G": 1, "c.7355G>C": 1}}	\N
7943780	7941119	c.4400A>G/c.7310C>T	{"RYR1": {"c.4400A>G": 1, "c.7310C>T": 1}}	\N
7943781	7941119	c.1565A>G/c.9758T>C	{"RYR1": {"c.1565A>G": 1, "c.9758T>C": 1}}	\N
7943782	7941119	c.7304G>A/c.14458G>A	{"RYR1": {"c.7304G>A": 1, "c.14458G>A": 1}}	\N
7943783	7941119	c.947G>T/c.7042_7044delGAG	{"RYR1": {"c.947G>T": 1, "c.7042_7044delGAG": 1}}	\N
7943784	7941119	c.7048G>A/c.14424C>A	{"RYR1": {"c.7048G>A": 1, "c.14424C>A": 1}}	\N
7943785	7941119	c.1024G>A/c.7084G>A	{"RYR1": {"c.1024G>A": 1, "c.7084G>A": 1}}	\N
7943786	7941119	c.982C>T/c.7487C>T	{"RYR1": {"c.982C>T": 1, "c.7487C>T": 1}}	\N
7943787	7941119	c.463C>A/c.6757C>T	{"RYR1": {"c.463C>A": 1, "c.6757C>T": 1}}	\N
7943788	7941119	c.3127C>T/c.7373G>T	{"RYR1": {"c.3127C>T": 1, "c.7373G>T": 1}}	\N
7943789	7941119	c.946C>T/c.6488G>A	{"RYR1": {"c.946C>T": 1, "c.6488G>A": 1}}	\N
7943790	7941119	c.251C>T/c.7036G>A	{"RYR1": {"c.251C>T": 1, "c.7036G>A": 1}}	\N
7943791	7941119	c.946C>T/c.6488G>C	{"RYR1": {"c.946C>T": 1, "c.6488G>C": 1}}	\N
7943792	7941119	c.7007G>A/c.8638G>A	{"RYR1": {"c.7007G>A": 1, "c.8638G>A": 1}}	\N
7943793	7941119	c.625G>A/c.982C>T	{"RYR1": {"c.625G>A": 1, "c.982C>T": 1}}	\N
7943794	7941119	c.14210G>A/c.14693T>C	{"RYR1": {"c.14210G>A": 1, "c.14693T>C": 1}}	\N
7943795	7941119	c.488G>A/c.14477C>T	{"RYR1": {"c.488G>A": 1, "c.14477C>T": 1}}	\N
7943796	7941119	c.12398A>G/c.12700G>C	{"RYR1": {"c.12398A>G": 1, "c.12700G>C": 1}}	\N
7943797	7941119	c.625G>A/c.742G>C	{"RYR1": {"c.625G>A": 1, "c.742G>C": 1}}	\N
7943798	7941119	c.1615T>G/c.6388G>A	{"RYR1": {"c.1615T>G": 1, "c.6388G>A": 1}}	\N
7943799	7941119	c.12398A>G/c.14545G>A	{"RYR1": {"c.12398A>G": 1, "c.14545G>A": 1}}	\N
7943800	7941119	c.625G>A/c.742G>A	{"RYR1": {"c.625G>A": 1, "c.742G>A": 1}}	\N
7943801	7941119	c.1209C>G/c.7060G>A	{"RYR1": {"c.1209C>G": 1, "c.7060G>A": 1}}	\N
7943802	7941119	c.7304G>A/c.14458G>T	{"RYR1": {"c.7304G>A": 1, "c.14458G>T": 1}}	\N
7943803	7941119	c.6478G>A/c.12700G>C	{"RYR1": {"c.6478G>A": 1, "c.12700G>C": 1}}	\N
7943804	7941119	c.5186T>G/c.14918C>T	{"RYR1": {"c.5186T>G": 1, "c.14918C>T": 1}}	\N
7943805	7941119	c.7199A>G/c.14209C>T	{"RYR1": {"c.7199A>G": 1, "c.14209C>T": 1}}	\N
7943806	7941119	c.1411C>T/c.7372C>T	{"RYR1": {"c.1411C>T": 1, "c.7372C>T": 1}}	\N
7943807	7941119	c.38T>G/c.5440A>G	{"RYR1": {"c.38T>G": 1, "c.5440A>G": 1}}	\N
7943808	7941119	c.6487C>T/c.7787C>T	{"RYR1": {"c.6487C>T": 1, "c.7787C>T": 1}}	\N
7943809	7941119	c.7035C>A/c.14558C>T	{"RYR1": {"c.7035C>A": 1, "c.14558C>T": 1}}	\N
7943810	7941119	c.14209C>T/c.14558C>T	{"RYR1": {"c.14209C>T": 1, "c.14558C>T": 1}}	\N
7943811	7941119	c.11958C>G/c.14210G>A	{"RYR1": {"c.11958C>G": 1, "c.14210G>A": 1}}	\N
7943812	7941119	c.5183C>T/c.6710G>A	{"RYR1": {"c.5183C>T": 1, "c.6710G>A": 1}}	\N
7943813	7941119	c.497A>G/c.6349G>C	{"RYR1": {"c.497A>G": 1, "c.6349G>C": 1}}	\N
7943814	7941119	c.1021G>A/c.9652G>A	{"RYR1": {"c.1021G>A": 1, "c.9652G>A": 1}}	\N
7943815	7941119	c.1654C>T/c.8198G>A	{"RYR1": {"c.1654C>T": 1, "c.8198G>A": 1}}	\N
7943816	7941119	c.463C>A/c.5186T>G	{"RYR1": {"c.463C>A": 1, "c.5186T>G": 1}}	\N
7943817	7941119	c.7042_7044delGAG/c.14126C>T	{"RYR1": {"c.14126C>T": 1, "c.7042_7044delGAG": 1}}	\N
7943818	7941119	c.6478G>A/c.12700G>T	{"RYR1": {"c.6478G>A": 1, "c.12700G>T": 1}}	\N
7943819	7941119	c.1589G>A/c.6757C>T	{"RYR1": {"c.1589G>A": 1, "c.6757C>T": 1}}	\N
7943820	7941119	c.6502G>A/c.9676G>C	{"RYR1": {"c.6502G>A": 1, "c.9676G>C": 1}}	\N
7943821	7941119	c.497A>G/c.14918C>T	{"RYR1": {"c.497A>G": 1, "c.14918C>T": 1}}	\N
7943822	7941119	c.6488G>A/c.7307G>A	{"RYR1": {"c.6488G>A": 1, "c.7307G>A": 1}}	\N
7943823	7941119	c.1841G>T/c.14582G>A	{"RYR1": {"c.1841G>T": 1, "c.14582G>A": 1}}	\N
7943824	7941119	c.3166G>C/c.12064A>G	{"RYR1": {"c.3166G>C": 1, "c.12064A>G": 1}}	\N
7943825	7941119	c.103T>C/c.1411C>T	{"RYR1": {"c.103T>C": 1, "c.1411C>T": 1}}	\N
7943826	7941119	c.479A>G/c.7282G>A	{"RYR1": {"c.479A>G": 1, "c.7282G>A": 1}}	\N
7943827	7941119	c.1615T>C/c.8600T>A	{"RYR1": {"c.1615T>C": 1, "c.8600T>A": 1}}	\N
7943828	7941119	c.178G>A/c.1841G>T	{"RYR1": {"c.178G>A": 1, "c.1841G>T": 1}}	\N
7943829	7941119	c.251C>T/c.1840C>T	{"RYR1": {"c.251C>T": 1, "c.1840C>T": 1}}	\N
7943830	7941119	c.6487C>T/c.13672C>T	{"RYR1": {"c.6487C>T": 1, "c.13672C>T": 1}}	\N
7943831	7941119	c.3127C>T/c.7373G>A	{"RYR1": {"c.3127C>T": 1, "c.7373G>A": 1}}	\N
7943832	7941119	c.103T>C/c.7292A>T	{"RYR1": {"c.103T>C": 1, "c.7292A>T": 1}}	\N
7943833	7941119	c.9310G>A/c.14424C>A	{"RYR1": {"c.9310G>A": 1, "c.14424C>A": 1}}	\N
7943834	7941119	c.680A>T/c.1589G>A	{"RYR1": {"c.680A>T": 1, "c.1589G>A": 1}}	\N
7943835	7941119	c.677T>A/c.1615T>G	{"RYR1": {"c.677T>A": 1, "c.1615T>G": 1}}	\N
7943836	7941119	c.1841G>T/c.9652G>A	{"RYR1": {"c.1841G>T": 1, "c.9652G>A": 1}}	\N
7943837	7941119	c.526G>A/c.7007G>A	{"RYR1": {"c.526G>A": 1, "c.7007G>A": 1}}	\N
7943838	7941119	c.7048G>A/c.8290G>A	{"RYR1": {"c.7048G>A": 1, "c.8290G>A": 1}}	\N
7943839	7941119	c.7060G>A/c.12398A>G	{"RYR1": {"c.7060G>A": 1, "c.12398A>G": 1}}	\N
7943840	7941119	c.1202G>T/c.14680G>A	{"RYR1": {"c.1202G>T": 1, "c.14680G>A": 1}}	\N
7943841	7941119	c.677T>A/c.1615T>C	{"RYR1": {"c.677T>A": 1, "c.1615T>C": 1}}	\N
7943842	7941119	c.7385C>T/c.14627A>G	{"RYR1": {"c.7385C>T": 1, "c.14627A>G": 1}}	\N
7943843	7941119	c.533A>C/c.533A>G	{"RYR1": {"c.533A>C": 1, "c.533A>G": 1}}	\N
7943844	7941119	c.533A>G/c.10042C>T	{"RYR1": {"c.533A>G": 1, "c.10042C>T": 1}}	\N
7943845	7941119	c.6838G>A/c.8005G>A	{"RYR1": {"c.6838G>A": 1, "c.8005G>A": 1}}	\N
7943846	7941119	c.103T>C/c.8198G>A	{"RYR1": {"c.103T>C": 1, "c.8198G>A": 1}}	\N
7943847	7941119	c.6628G>T/c.12553G>A	{"RYR1": {"c.6628G>T": 1, "c.12553G>A": 1}}	\N
7943848	7941119	c.7372C>T/c.14818G>A	{"RYR1": {"c.7372C>T": 1, "c.14818G>A": 1}}	\N
7943849	7941119	c.488G>T/c.1024G>A	{"RYR1": {"c.488G>T": 1, "c.1024G>A": 1}}	\N
7943850	7941119	c.7304G>A/c.14422_14423delinsAA	{"RYR1": {"c.7304G>A": 1, "c.14422_14423delinsAA": 1}}	\N
7943851	7941119	c.677T>A/c.7291G>T	{"RYR1": {"c.677T>A": 1, "c.7291G>T": 1}}	\N
7943852	7941119	c.7879G>C/c.11953T>C	{"RYR1": {"c.7879G>C": 1, "c.11953T>C": 1}}	\N
7943853	7941119	c.463C>A/c.1422G>T	{"RYR1": {"c.463C>A": 1, "c.1422G>T": 1}}	\N
7943854	7941119	c.7063C>T/c.8189A>G	{"RYR1": {"c.7063C>T": 1, "c.8189A>G": 1}}	\N
7943855	7941119	c.1021G>C/c.7879G>A	{"RYR1": {"c.1021G>C": 1, "c.7879G>A": 1}}	\N
7943856	7941119	c.533A>C/c.6488G>T	{"RYR1": {"c.533A>C": 1, "c.6488G>T": 1}}	\N
7943857	7941119	c.533A>C/c.6488G>A	{"RYR1": {"c.533A>C": 1, "c.6488G>A": 1}}	\N
7943858	7941119	c.5186T>G/c.6612C>G	{"RYR1": {"c.5186T>G": 1, "c.6612C>G": 1}}	\N
7943859	7941119	c.7043A>G/c.13913G>A	{"RYR1": {"c.7043A>G": 1, "c.13913G>A": 1}}	\N
7943860	7941119	c.677T>A/c.7291G>A	{"RYR1": {"c.677T>A": 1, "c.7291G>A": 1}}	\N
