-- Data for Name: file_note; Type: TABLE DATA; Schema: cpic; Owner: -
--

COPY cpic.file_note (type, entityid, note, ordinal, version) FROM stdin;
ALLELE_DEFINITION	CYP3A5	The variants included are based on the PharmVar core alleles (for core alleles only see https://www.pharmvar.org/gene/CYP3a5).	0	1
ALLELE_DEFINITION	CYP3A5	See PharmVar website (http://www.pharmvar.org) for comprehensive haplotype definitions of CYP3A5 variant alleles, including sub-alleles, and updated allele information.	1	1
ALLELE_DEFINITION	CYP3A5	rsID=RefSNP accession ID number (http://www.ncbi.nlm.nih.gov/snp/)	2	1
ALLELE_DEFINITION	CYP3A5	All variants are annotated to the positive DNA strand.	3	1
ALLELE_DEFINITION	CYP3A5	An important caveat for all genotyping tests is that the decision to assign an allele a "wild- type" status is based upon a genotyping test that interrogates only the most common and already-proven sites of functional variation. In human DNA, it is always possible that a new, previously undiscovered (and therefore un-interrogated) site of variation may confer loss-of- function in an individual, and thus lead to the rare possibility of a non-functional allele being erroneously called as "wild-type"	4	1
ALLELE_DEFINITION	CYP3A5	Citations for assignment of function can be found at https://www.pharmgkb.org/page/cyp3a5RefMaterials	5	1
ALLELE_DEFINITION	CYP3A5	Content is accessed through the PharmVar API. HGVS and 'PharmVar-style' (accessible on the PharmVar website) positions may differ for indels in some instances which is most likely explained by differences in sequence alignments. Also, PharmVar displays single nucleotide insertions as 'ins' while the HGVS display is as duplications or 'dub' if the insertion is the same base as the prior base.	6	1
ALLELE_DEFINITION	TPMT	rsID=RefSNP accession ID number (http://www.ncbi.nlm.nih.gov/snp/)	0	1
ALLELE_DEFINITION	TPMT	All variants are annotated to the positive DNA strand.	1	1
ALLELE_DEFINITION	TPMT	Variants are sourced from the TPMT nomenclature committee (TPMT Alleles), see https://liu.se/en/research/tpmt-nomenclature-committee	2	1
ALLELE_DEFINITION	CYP4F2	rsID=RefSNP accession ID number (http://www.ncbi.nlm.nih.gov/snp/)	0	1
ALLELE_DEFINITION	CYP4F2	All variants are annotated to the positive DNA strand.	1	1
ALLELE_DEFINITION	CYP4F2	See PharmVar website (http://pharmvar.org) for comprehensive haplotype definitions of CYP4F2 variant alleles and updated allele information.	2	1
ALLELE_DEFINITION	CYP4F2	An important caveat for all genotyping tests is that the decision to assign an allele a "wild-type" status is based upon a genotyping test that interrogates only the most common and already-proven sites of functional variation. In human DNA, it is always possible that a new, previously undiscovered (and therefore un-interrogated) site of variation may confer loss-of-function in an individual, and thus lead to the rare possibility of a non-functional allele being erroneously called as "wild-type."	3	1
ALLELE_DEFINITION	UGT1A1	rsID=RefSNP accession ID number (http://www.ncbi.nlm.nih.gov/snp/)	0	1
ALLELE_DEFINITION	UGT1A1	All variants are annotated to the positive DNA strand.	1	1
FREQUENCY	CYP2C9	For full references see "References" tab.	0	1
ALLELE_DEFINITION	DPYD	Variant selection is based on the CPIC guideline for Fluoropyrimidines and DPYD (https://cpicpgx.org/guidelines/guideline-for-fluoropyrimidines-and-dpyd/) and sourced from PharmVar (https://www.pharmvar.org/gene/DPYD).	0	1
ALLELE_DEFINITION	DPYD	All variants are annotated to the positive DNA strand.	1	1
ALLELE_DEFINITION	DPYD	As an individual only carries a maximum of two fully functional DPYD copies, common normal function variants may be located on the same gene copy as other normal	2	1
ALLELE_DEFINITION	DPYD	c.1129-5923C>G is likely the HapB3 haplotype causal variant. c.1236G>A (E412E) is a proxy SNP for HapB3.	3	1
ALLELE_DEFINITION	UGT1A1	To see a full list of known UGT1A1 alleles see https://www.pharmacogenomics.pha.ulaval.ca/wp-content/uploads/2015/04/UGT1A1-allele-nomenclature.html	2	1
ALLELE_FUNCTION_REFERENCE	NAT2	NAT Gene Nomenclature Committee Homepage, https://nat.mbg.duth.gr/Homepage.htm	1	1
ALLELE_DEFINITION	DPYD	Individual patients have been reported (PMID 38129972) to carry only one of the two SNPs in the HapB3 haplotype (i.e., c.1236G>A without c.1129-5923C>G), suggesting that the two variants are not in complete linkage disequilibrium. CPIC updated the allele definition to include the c.1129-5923C>G SNP separately as this is likely the causal variant leading to decreased function. CPIC also retained the HapB3 haplotype definition for cases where only the c.1236G>A variant is tested (e.g. whole exome sequencing). While CPIC recommends to directly test the causal SNP if possible, in cases where only c.1236G>A is tested or results are available for, it should be clearly stated in the test report that "decreased function" was inferred by detecting the exonic tag SNP, and disclose that in rare cases, the causal decreased function variant c.1129-5923C>G may not be present despite having this tag SNP.	4	1
ALLELE_DEFINITION	DPYD	c.680+139G>A is not exclusive to HapB3 and therefore not a suitable proxy.	5	1
ALLELE_DEFINITION	DPYD	rsID rs3918290, when combined with rs1801159, makes up DPYD*2B	6	1
ALLELE_DEFINITION	DPYD	rs56293913, rs3790387, rs2811202 are all part of a common haplotype that also encompasses c.496A>G (M166V).	7	1
ALLELE_DEFINITION	DPYD	The rs115632870 variant was found to be in linkage disequilibrium (D'=1) with the decreased function variant rs115232898 (Y186C); the decreased function associated with this variant is likely due to this linkage.	8	1
ALLELE_DEFINITION	DPYD	Content is accessed through the PharmVar API. HGVS and 'PharmVar-style' (accessible on the PharmVar website) positions may differ for indels in some instances which is most likely explained by differences in sequence alignments. Also, PharmVar displays single nucleotide insertions as 'ins' while the HGVS display is as duplications or 'dub' if the insertion is the same base as the prior base.	9	1
ALLELE_DEFINITION	UGT1A1	An important caveat for all genotyping tests is that the decision to assign an allele a "wild-type" status is based upon a genotyping test that interrogates only the most common and already- proven sites of functional variation. In human DNA, it is always possible that a new, previously undiscovered (and therefore un-interrogated) site of variation may confer loss-of-function in an individual, and thus lead to the rare possibility of a non-functional allele being erroneously called as "wild-type".	3	1
ALLELE_DEFINITION	G6PD	This modified table of G6PD variants is from PMID:22293322, https://grenada.lumc.nl/LOVD2/MR/home.php?select_db=G6PD, with several additional variants.	0	1
ALLELE_DEFINITION	G6PD	rsID=RefSNP accession ID number (http://www.ncbi.nlm.nih.gov/snp/)	1	1
ALLELE_DEFINITION	G6PD	All variants are annotated to the positive DNA strand.	2	1
ALLELE_DEFINITION	G6PD	Please note; WHO class as reported in PMID:22293322 and Luzzatto, L. & Poggi, V. Glucose-6-Phosphate Dehydrogenase Deficiency In: Nathan and Oski's Hematology of Infancy and Childhood, 7th Edition (ed. Meloni, D., Anderson, A. Authors of the book: Orkin, S.H., Fisher, D.E., Look, A.T., Lux IV, S.E., Ginsburg, D., Nathan, D.G. ) (Saunders, Elsevier., 2009) or individual references. This class may have been assigned based on just clinical\nmanifestations and not enzyme activity level or characterization of the enzyme variant.	3	1
ALLELE_DEFINITION	G6PD	Likely phenotype as referenced in this guideline, based on converting assigned WHO class to 3 phenotypes. "Normal" defined as very mild or no enzyme deficiency (>60% normal enzyme levels); "Deficient" defined as mild to severely deficient (<10-60% normal) enzyme levels; "Deficient with CNSHA" defined as severe G6PD enzyme deficiency (<10% activity) with chronic non-spherocytic hemolytic anemia based on Luzzatto, L. & Poggi, V. Glucose-6-Phosphate Dehydrogenase Deficiency In: Nathan and Oski's Hematology of Infancy and Childhood, 7th Edition (ed. Meloni, D., Anderson, A. Authors of the book: Orkin, S.H., Fisher, D.E., Look, A.T., Lux IV, S.E., Ginsburg, D., Nathan, D.G. ) (Saunders, Elsevier., 2009).	4	1
ALLELE_DEFINITION	UGT1A1	Citations for assignment of function can be found at https://www.pharmgkb.org/page/ugt1a1RefMaterials	4	1
ALLELE_DEFINITION	UGT1A1	UGT1A1*80 is in very high linkage disequilibrium with *28 and *37. However, the function of the *80 allele alone, in the absence of *28 or *37, is uncertain. If a patient is only tested for *80, decreased function may be inferred, though linkage is not 100%.	5	1
ALLELE_FUNCTION_REFERENCE	NAT2	Legacy NAT2 allele nomenclature and functional assignments, https://nat.mbg.duth.gr/Human_NAT2_alleles.htm	2	1
ALLELE_DEFINITION	IFNL3	rsID=RefSNP accession ID number (http://www.ncbi.nlm.nih.gov/snp/)	0	1
ALLELE_DEFINITION	IFNL3	All variants are annotated to the positive DNA strand.	1	1
ALLELE_DEFINITION	UGT1A1	TA repeat: Historically in the literature and at the UGT nomenclature website, the TA repeat is referred to as TA(6) for *1, TA(7) for *28, TA(5) for *36, etc. The UGT allele nomenclature website (https://www.pharmacogenomics.pha.ulaval.ca/wp-content/uploads/2015/04/UGT1A1-allele-nomenclature.html) defines them in more detail as for example: A(TA)6TAA to A(TA)7TAA for *28 and A(TA)6TAA to A(TA)5TAA for *36. Note that after the repeat and number, there is an additional TA listed in the flanking sequence as "TAA". Similar nomenclature/representation is in cell C2 of the table on the "Alleles" tab as historical referencing ("CA" in front as an anchor for the point in the sequence that the TA repeats are starting from). Rows 4 and 5 align with the indicated reference sequences. In cells C4 and C5, when counting from the first TA at the given position in the sequence and including the last TA, the 5, 6, 7, 8 repeats become 6, 7, 8, 9 because there are actually 6 to 9 "TA" repeats in the genomic and gene reference sequences.	6	1
ALLELE_FUNCTION_REFERENCE	NAT2	PharmVar NAT2 Read Me, https://a.storyblok.com/f/70677/x/047a3728ff/gene-info_nat2_v1-2.pdf.	3	1
GENE_CDS	ABCG2	For this example, a priority result is defined as a genetic test result that results in a change in drug, drug dose, or drug monitoring.	1	1
GENE_CDS	ABCG2	The specific wording of the interpretive text may differ among sites.	2	1
GENE_CDS	CYP2B6	The phenotype is used to store an interpretation of the test result. This is a design decision that may differ among sites.	0	1
GENE_CDS	CYP2B6	For this example, a priority result is defined as a genetic test result that results in a change in drug, drug dose, or drug monitoring.	1	1
GENE_CDS	CYP2B6	The specific wording of the interpretive text may differ among sites.	2	1
GENE_CDS	CYP2B6	Although two CYP2B6 alleles, *4 and *22, are categorized as increased function alleles, the effect of *4 and *22 on CYP2B6 function with respect to efavirenz plasma exposure appears to be modest based on current evidence. However, the phenotype categories of CYP2B6 rapid metabolizer (RM; one normal function allele and one increased function allele) and CYP2B6 ultra-rapid metabolizer (UM; two increased function alleles) were created to allow for the possibility that these may be clinically relevant for CYP2B6 substrates other than efavirenz. As there is no recommendation for altering dosing for CYP2B6 RMs or UMs for efavirenz, the EHR priority is sent to "normal" for these metabolizers.	3	1
ALLELE_DEFINITION	MT-RNR1	Variant selection based on the CPIC guideline for aminoglycoside antibiotics and MT-RNR1.	0	1
ALLELE_DEFINITION	VKORC1	rsID=RefSNP accession ID number (http://www.ncbi.nlm.nih.gov/snp/)	0	1
DIPLOTYPE_PHENOTYPE	RYR1	The CPIC guideline includes RYR1 variants assigned a Allele Clinical Functional Status of Normal function, Uncertain function, and Malignant Hyperthermia associated (see the "RYR1_allele_functionality_reference" file). A translation of Allele Function combinations to Phenotype is available in the "RYR1_phenotypes" file. It might be possible that a subject could have more than 2 RYR1 variants and this RYR1_Diplotype_Phenotype_Table is a representation of possible RYR1 genotypes considering the two functionally most impacted RYR1 variants.	0	1
ALLELE_DEFINITION	VKORC1	All variants are annotated to the positive DNA strand.	1	1
ALLELE_FUNCTION_REFERENCE	RYR1	Variant selection based on an update of the CPIC guideline for potent volatile anesthetic agents and succinylcholine. The guideline update includes the published list of RYR1 variants (supplemental Table S2), which are evaluated by the ClinGen malignant hyperthermia susceptibility (MHS) variant curation expert panel (VCEP) and classified for RYR1-related malignant hyperthermia susceptibility based on specified ACMG/AMP criteria (PMID 35849058). The entries in the column 'Allele Functional Status (Optional)' are from the 'Pathogenicity' column and the entries in the column 'Findings (Optional)' are from the ACMG/AMP Criteria column in Table S2 (PMID 35849058).	0	1
ALLELE_FUNCTION_REFERENCE	RYR1	Variants 1209C>G, 7522C>G, 14387A>G, 14693T>C are not included in the PMID 35849058 and are classified as VUS by the RYR1 VCEP in May 2023.	1	1
ALLELE_FUNCTION_REFERENCE	RYR1	Variant classification was re-evaluated and updated by the RYR1 VCEP in May 2023 for the following variants: c.488G>T, c.1589G>A, c.7522C>T, c.14210G>A, c.14582G>A, c.6612C>G, c.14918C>T, c.5183C>T, c.5132A>G, c.6838G>A	2	1
ALLELE_FUNCTION_REFERENCE	RYR1	Variant classification was re-evaluated and updated by the RYR1 VCEP in Nov 2023 for the following variants: c.6488G>T, c.14627A>G, c.14813T>C	3	1
ALLELE_FUNCTION_REFERENCE	RYR1	Allele Clinical Functional Status is mapped to the classification by the ClinGen malignant hyperthermia susceptibility (MHS) variant curation expert panel PMID: 35849058 as follows:	4	1
ALLELE_FUNCTION_REFERENCE	RYR1	Pathogenic = Malignant Hyperthermia associated	5	1
ALLELE_FUNCTION_REFERENCE	RYR1	Likely Pathogenic = Malignant Hyperthermia associated	6	1
ALLELE_FUNCTION_REFERENCE	RYR1	Variant of uncertain significance = Uncertain function	7	1
ALLELE_FUNCTION_REFERENCE	RYR1	Likely Benign = Normal function	8	1
ALLELE_DEFINITION	NAT2	rsID = RefSNP accession ID number (http://www.ncbi.nlm.nih.gov/snp/)	0	1
ALLELE_DEFINITION	NAT2	All variants are annotated to the positive DNA strand.	1	1
ALLELE_DEFINITION	NAT2	Structural variants are represented using the PharmVar ID.	2	1
ALLELE_DEFINITION	NAT2	See PharmVar website (http://www.pharmvar.org) for comprehensive haplotype definitions of NAT2 variant alleles and updated allele information.	3	1
ALLELE_DEFINITION	NAT2	An important caveat for all genotyping tests is that the decision to assign an allele a "wild-type" status is based upon a genotyping test that interrogates only the most common and already-proven sites of functional variation. In human DNA, it is always possible that a new, previously undiscovered (and therefore un-interrogated) site of variation may confer loss-of-function in an individual, and thus lead to the rare possibility of a non-functional allele being erroneously called as "wild-type."	4	1
ALLELE_DEFINITION	NAT2	Some drastic changes have been made to NAT2 nomenclature during transition from the original (Database of Arylamine N-Acetyltransferases (NATs)) to the new (https://www.pharmvar.org/gene/NAT2) "star" allele definitions:	5	1
ALLELE_DEFINITION	NAT2	The NAT2 reference allele has now changed: The NG_012246.1 RefSeq differs from X14672.1 (which was used in the past to define star alleles) at the position that corresponds to c.803 (rs1208), where X14672.1 has "A" while NG_012246.1 has "G". Thus, depending on which reference sequence is utilized, this position is reported as either reference or variant. The transition of allele definitions to the NG_012246.1 RefSeq caused "variant switching", meaning that all star alleles which were previously described as having c.803A>G lost this variant, as "G" is now considered reference, while all other star alleles gained c.803G>A, as "A" is now considered variant.	6	1
ALLELE_DEFINITION	NAT2	The new reference allele is now catalogued as NAT2*1: The sequence of NG_012246.1 RefSeq corresponds to the allele that was formerly described as NAT2*12A. Its renaming as NAT2*1.001 facilitates the application of PharmVar rules to NAT2 allelic nomenclature, while it also enables the use of NAT2*1 name to describe the reference allele, in line with the star allele nomenclature of other pharmacogenes. To avoid confusion during the transition from the legacy to the new nomenclature, *12 is now retired. Having a NAT2*1 allele grouping in place also facilitates NGS analyses using GRCh38 as a reference.	7	1
ALLELE_FUNCTION_REFERENCE	CYP2B6	CYP2B6 functional metabolic effects may be substrate specific (and extrapolations to other substrates may not be reliable).	0	1
ALLELE_FUNCTION_REFERENCE	RYR1	Benign = Normal function	9	1
FREQUENCY	CYP2B6	Average frequencies based on the reported frequencies in one or multiple studies.	1	1
ALLELE_DEFINITION	CACNA1S	Variant selection based on the CPIC guideline for potent volatile anesthetic agents and succinylcholine and RYR1 and CACNA1S.	0	1
ALLELE_DEFINITION	NAT2	NAT2*4 is no longer considered as the reference allele: Alleles carrying c.803G>A as their only amino acid changing SNV will be called as *4 according to the new nomenclature. This includes the former NAT2*4 reference allele of sequence X14672.1, now considered a variant and listed as NAT2*4.001. Although this will no longer be used as a reference, it is considered to be functionally equivalent to NAT2*1.001 (formerly NAT2*12A) and may still be used to compare the enzymatic or structural properties of polymorphic NAT2 proteins.	8	1
ALLELE_DEFINITION	NAT2	Not all previously defined star alleles have been transferred: In the past, it has not always been clear how a NAT2 haplotype was determined. Many have been inferred via computational phase analysis and were not verified experimentally. In the case of haplotypes where the available evidence from the literature was deemed insufficient to support confident allele definition, those haplotypes were not transferred to PharmVar, but they will remain posted on the original Database of Arylamine N-Acetyltransferases (NATs).	9	1
ALLELE_DEFINITION	NAT2	This file contains the PharmVar NAT2 core allele definitions.	10	1
ALLELE_DEFINITION	NAT2	Alleles with content annotated in PharmGKB but not included in PharmVar (*5G, *5J, *5M, *5U, *6J, *7G, *17) are added using the the original Database of Arylamine N-Acetyltransferases (NATs, http://nat.mbg.duth.gr/Human%20NAT2%20alleles_2013.htm) definitions. This results in the inclusion of 2 synonymous SNPs (added in grey). PharmVar NAT2 core alleles do not include these SNPs although those are part of many NAT2 suballeles and the cells in the core alleles are therefore left blank in this file (see PharmVar for all transitioned NAT2 suballeles and about what is included in a core allele definition). Additionally, with transitioning to PharmVar, the change at p.268 is now according to the reference sequence R268K (see above information). Therefore, original definitions that include K268R will have a blank cell, while alleles that did not include the SNP will now have an "A" at this position.\nPositions added: \n226T>G part of *7G\n434A>C part of *17\n282C>T and 481C>T synonymous SNPs\n*5G has K268R - 803G =ref at this position, therefore blank\n*5J has 803A \n*5M has K268R - 803G =ref at this position, therefore blank\n*5U has K268R - 803G =ref at this position, therefore blank\n*6J has 803A \n*7G has 803A \n*17 has 803A	11	1
FREQUENCY	CYP3A5	For full references see "References" tab.	0	1
ALLELE_DEFINITION	CFTR	rsID=RefSNP accession ID number (http://www.ncbi.nlm.nih.gov/snp/)	0	1
ALLELE_DEFINITION	CFTR	All variants are annotated to the positive chromosomal strand.	1	1
ALLELE_DEFINITION	CFTR	Class is defined in PMID: 20932301.	2	1
ALLELE_DEFINITION	CFTR	Table includes variants listed as ivacaftor responsive on FDA-approved ivacaftor (Kalydeco) label (see change log for updates).	3	1
ALLELE_DEFINITION	CFTR	The ivacaftor (Kalydeco) label includes the CFTR variants as amino acid changes. Based on information in dbSNP, for four variants, the amino acid change can be coded by >1 nucleotide change at the same genomic position. In these cases the variant was named with the protein change and the nucleotide change in parentheses.	4	1
ALLELE_DEFINITION	CFTR	The ivacaftor label includes F311del. The variant is caused by a 3 bp deletion within a repetitive sequence C TTC TTC TTC T at nucleotide position 1059-1069. This results in a deletion of one of the phenylalanine residues at either position 311, 312 or 313.	5	1
ALLELE_DEFINITION	CFTR	F508C;S1251N includes the following footnote for Table 3 of the FDA-approved ivacaftor label (annotated by ClinPGx 10/05/2023): "Complex/compound mutations where a single allele of the CFTR gene has multiple mutations; these exist independent of the presence of mutations on the other allele."	6	1
ALLELE_DEFINITION	NUDT15	PharmVAR releases new alleles based on received submissions, see https://www.pharmvar.org/gene/NUDT15 for comprehensive haplotype definitions of NUDT15 variant alleles, including sub-alleles, and updated allele information.	0	1
ALLELE_DEFINITION	NUDT15	The variants included in the alleles are based on the PharmVar core alleles (for core allele definitions only, see https://www.pharmvar.org/gene/NUDT15). In addition, variants that present in the core allele for one star allele but also present in some but not all suballeles of another star allele are included in the other star allele as ambiguous changes, e.g. the *3 consensus allele includes a "GAGTCG(3) or GAGTCG(4)" at the position 55_56insGAGTCG since this variant defines the *6 core allele but is not part of the *3 core allele definition in PharmVar since it is not present in all *3 suballeles. These postions are represented in grey (G) in the Comparative Allele ViewEr (CAVE) tool at PharmVar.	1	1
ALLELE_DEFINITION	CYP2B6	rsID=RefSNP accession ID number (http://www.ncbi.nlm.nih.gov/snp/)	0	1
ALLELE_DEFINITION	CYP2B6	All variants are annotated to the positive chromosomal strand.	1	1
ALLELE_DEFINITION	CYP2B6	See PharmVar website (http://www.pharmvar.org) for comprehensive haplotype definitions of CYP2B6 variant alleles and updated allele information.	2	1
ALLELE_DEFINITION	CYP2B6	An important caveat for all genotyping tests is that the decision to assign an allele a "wild-type" status is based upon a genotyping test that interrogates only the most common and already-proven sites of functional variation. In human DNA, it is always possible that a new, previously undiscovered (and therefore un-interrogated) site of variation may confer loss-of-function in an individual, and thus lead to the rare possibility of a non-functional allele being erroneously called as "wild-type."	3	1
ALLELE_DEFINITION	NUDT15	rsID=RefSNP accession ID number (http://www.ncbi.nlm.nih.gov/snp/)	2	1
ALLELE_DEFINITION	NUDT15	All variants are annotated to the positive DNA strand.	3	1
ALLELE_DEFINITION	NUDT15	rs554405994 was merged into rs869320766 which was merged into rs746071566	4	1
ALLELE_DEFINITION	NUDT15	Content is accessed through the PharmVar API. HGVS and 'PharmVar-style' (accessible on the PharmVar website) positions may differ for indels in some instances which is most likely explained by differences in sequence alignments. Also, PharmVar displays single nucleotide insertions as 'ins' while the HGVS display is as duplications or 'dub' if the insertion is the same base as the prior base.	5	1
ALLELE_FUNCTION_REFERENCE	CYP2D6	CNV alleles are based on Table 2 'CYP2D6 Identical Gene Duplications/Multiplications' from the PharmVar CYP2D6 structural variation document (https://a.storyblok.com/f/70677/x/d80b535e9c/cyp2d6_structural-variation_v3-2.pdf).	0	1
ALLELE_FUNCTION_REFERENCE	RYR1	"Reference" is included in the CPIC RYR1 allele definition table. Allele Clinical Functional Status is assigned Normal function.	10	1
GENE_CDS	CACNA1S	The phenotype is used to store an interpretation of the test result. This is a design decision that may differ among sites.	0	1
GENE_CDS	CACNA1S	For this example, a priority result is defined as a genetic test result that results in a change in drug, drug dose, or drug monitoring.	1	1
GENE_CDS	CACNA1S	The specific wording of the interpretive text may differ among sites.	2	1
GENE_CDS	CYP2C19	The phenotype is used to store an interpretation of the test result. This is a design decision that may differ among sites.	0	1
GENE_CDS	CYP2C19	For this example, a priority result is defined as a genetic test result that results in a change in drug, drug dose, or drug monitoring.	1	1
GENE_CDS	CYP2C19	The specific wording of the interpretive text may differ among sites.	2	1
FREQUENCY	CYP2B6	Based on the PharmGKB biogeographical groups https://www.pharmgkb.org/page/biogeographicalGroups	2	1
DIPLOTYPE_PHENOTYPE	DPYD	It is possible that a subject has > 2 DPYD variants and this DPYD_Diplotype_Phenotype_Table is a representation of possible DPYD genotypes considering the two functionally most impacted (lowest activity value) variants. Based on the CPIC guideline for Dihydropyrimidine Dehydrogenase Genotype and Fluoropyrimidine Dosing: 2017 Update (PMID: 29152729), the DPD phenotype is assigned using a gene activity score (DPYD-AS; based on the DPYD Allele Functionality Table), calculated as the sum of the two DPYD variants with the lowest variant activity value. A translation of Allele Function combinations to Phenotype is available in the "DPYD_phenotypes" file. If two decreased/no function variants are present, each decreased/no function variant is considered to be on a different gene copy when the phase is not known.	0	1
ALLELE_DEFINITION	CYP2C19	The variants included in the alleles are based on the PharmVar core alleles (for core allele definitions only, see https://www.pharmvar.org/gene/CYP2C19). In addition, variants that present in the core allele for one star allele but also present in some but not allsuballeles of another star allele are included in the other star allele as ambiguous changes using the IUPAC nucleotide code (https://www.bioinformatics.org/sms/iupac.html), e.g. the *4 consensus allele includes a "Y" being either C or T at the -806C>T position since this variant is part of the *17 core allele but is not part of the *4 core allele at PharmVar since it is not present in all *4 suballeles. These postions are represented in grey in the Comparative Allele ViewEr (CAVE) tool at PharmVar.	0	1
GENE_CDS	ABCG2	The phenotype is used to store an interpretation of the test result. This is a design decision that may differ among sites.	0	1
ALLELE_DEFINITION	CYP2C19	PharmVAR releases new alleles based on received submissions, see https://www.pharmvar.org for comprehensive haplotype definitions of CYP2C19 variant alleles, including sub-alleles, and updated allele information.	1	1
ALLELE_DEFINITION	CYP2C19	rsID=RefSNP accession ID number (http://www.ncbi.nlm.nih.gov/snp/)	2	1
ALLELE_DEFINITION	CYP2C19	All variants are annotated to the positive DNA strand.	3	1
ALLELE_DEFINITION	CYP2C19	An important caveat for all genotyping tests is that the decision to assign an allele a wild-type status is based upon a genotyping test that interrogates only the most common and already- proven sites of functional variation. It is always possible that a novel, previously undiscovered (and therefore un-interrogated) site of variation may confer loss-of-function in an individual, and thus lead to the rare possibility of a non-functional allele being erroneously called as wild-type.	4	1
ALLELE_DEFINITION	CYP2C19	The deterimental CYP2C19*4-defining SNP (rs28399504) has been identified to be linked (i.e. on the same chromosome) with *17 (-806C>T; rs12248560) in certain ethnic subpopulations. To distinguish the *4 (no function) and *17 (increased function) alleles, both rs28399504 and rs12248560 needs to be genotyped [PMID: 21358751, PMID: 24012947]). This haplotype is designated CYP2C19*4B [PMID: 21716271, PMID: 21358751].	5	1
ALLELE_DEFINITION	CYP2C19	The SNP c.463G>T (rs374036992) has been identified to occur in linkage with the *17-defining SNP (- 806C>T; rs12248560). To distinguish *17 from this haplotype, c.463G>T needs to be genotyped [PMID: 25141895]. This allele has not been submitted to PharmVar for a star allele designation.	6	1
ALLELE_DEFINITION	CYP2C19	CYP2C19*27 was reassigned to CYP2C19*1.006 with PharmVar Version 4.0 Last Updated May 7 2019	7	1
ALLELE_DEFINITION	CYP2C19	CYP2C19*36 is a full gene deletion and *37 is a partial gene deletion that includes at least exon 1; for details see the PharmVar CYP2C19 GeneFocus (PMID 32602114) and the CYP2C19 Structural Variation document at https://www.pharmvar.org/gene/CYP2C19).	8	1
ALLELE_DEFINITION	CYP2C19	CYP2C19*38 was set as reference allele as this allele matches the human genome CYP2C19 Reference sequence LRG_584 / NG_008384.3. The RefSeq (LRG_584 / NG_008384.3) has 80161A while many of star alleles, including all *1 suballeles have 80161G. Thus, the CYP2C19*1 core allele is defined by one amino acid (I331V), while the *38 core allele definition does not have any amino acid changes.	9	1
ALLELE_DEFINITION	RYR1	Variant selection based on an update of the CPIC guideline for potent volatile anesthetic agents and succinylcholine. The guideline update includes the published list of RYR1 variants (supplemental table S2), which are evaluated by the ClinGen malignant hyperthermia susceptibility (MHS) variant curation expert panel and classified for RYR1-related malignant hyperthermia susceptibility based on specified the ACMG/AMP criteria (PMID 35849058).	0	1
ALLELE_DEFINITION	RYR1	The deletion of an E can be represented as E2347del orE2348del (c.7039_7041delGAG or c.7042_7044delGAG, respectivly). c.7042_7044delGAG is used to name the variant in the file to reflect the ClinGen naming, however the mapping of the variant is done according to the corresponding rsID rs121918596.	1	1
ALLELE_FUNCTION_REFERENCE	NAT2	The NAT gene nomenclature committee has curated, annotated, and assigned function to NAT2 star alleles since 1997. In March 2024, NAT2 nomenclature was transferred to PharmVar with some major changes. Most notably, the creation of NAT2*1 as the reference allele in accordance with the reference genome GRCh38. NAT2*4, the former reference allele, is defined by the presence of the SNV c.803G>A. Historically, acetylation function was assigned to NAT2 * alleles as either "rapid" or "slow". Under the CPIC allele function terminology, rapid acetylation alleles are categorized as "Increased Function" and slow acetylation alleles are categorized as "Decreased Function". More information can be found at the NAT gene nomenclature committee website, including legacy allele nomenclature and functional assignments (see links below). Additionally, see the PharmVar NAT2 Read Me document (link below)	0	1
FREQUENCY	CACNA1S	For full references see "References" tab.	0	1
ALLELE_DEFINITION	CYP2C9	PharmVAR releases new alleles based on received submissions, see https://www.pharmvar.org for comprehensive haplotype definitions of CYP2C9 variant alleles, including sub-alleles, and updated allele information.	0	1
ALLELE_DEFINITION	CYP2C9	rsID=RefSNP accession ID number (http://www.ncbi.nlm.nih.gov/snp/)	1	1
ALLELE_DEFINITION	CYP2C9	All variants are annotated to the positive DNA strand.	2	1
ALLELE_DEFINITION	CYP2C9	An important caveat for all genotyping tests is that the decision to assign an allele a "wild-type" status is based upon a genotyping test that interrogates only the most common and already-proven sites of functional variation. In human DNA, it is always possible that a new, previously undiscovered (and therefore un-interrogated) site of variation may confer loss-of-function in an individual, and thus lead to the rare possibility of a non-functional allele being erroneously called as "wild-type."	3	1
ALLELE_DEFINITION	CYP2C9	Citations for assignment of function can be found at https://www.pharmgkb.org/page/cyp2c9RefMaterials	4	1
ALLELE_DEFINITION	CYP2C9	Content is accessed through the PharmVar API. HGVS and 'PharmVar-style' (accessible on the PharmVar website) positions may differ for indels in some instances which is most likely explained by differences in sequence alignments. Also, PharmVar displays single nucleotide insertions as 'ins' while the HGVS display is as duplications or 'dub' if the insertion is the same base as the prior base.	5	1
ALLELE_DEFINITION	CYP2D6	The variants included in the alleles are based on the PharmVar core alleles (for core allele definitions only, see https://www.pharmvar.org/gene/CYP2D6). In addition, variants that present in the core allele for one star allele but also present in some but not all suballeles of another star allele are included in the other star allele as ambiguous changes using the IUPAC nucleotide code (https://www.bioinformatics.org/sms/iupac.html), e.g. the *4 consensus allele includes a "R" being either G or A (positive strand) at the 100C>T (P34S) position since this variant is part of other core star alleles, e.g. *10, but is not part of the *4 core allele at PharmVar since it is not present in all *4 suballeles. These postions are represented in grey (G) in the Comparative Allele ViewEr (CAVE) tool at PharmVar. The g.42129130C>G position is an exception. The SNP by itself causes a synonymous change, therefore by itself the SNP would not be part of a core allele based on the core allele definition. However, in *29 and *70 the SNP is needed for the amino acid change and therefore part of the *29 and *70 core allele definition in PharmVar. To follow the above, "S" is added at the position for star alleles in which not all suballeles carry the SNP. In case all suballeles have the SNP "G" is added.	0	1
ALLELE_DEFINITION	CYP2D6	At PharmVar, information about duplications and gene hybrids are available through https://www.pharmvar.org/gene-support/Variation_CYP2D6.pdf.	1	1
ALLELE_DEFINITION	CYP2D6	PharmVAR releases new alleles based on received submissions, see https://www.pharmvar.org for comprehensive haplotype definitions of CYP2D6 variant alleles, including sub-alleles, and updated allele information.	2	1
ALLELE_DEFINITION	CYP2D6	Amino acid changes are displayed per single variantion. However, in some alleles the 2 consecutive variants together cause a different amino acid change as each by itself. *29, *70: 1660G>A and 1662G>C result in V136I; *82: 1021A>T and 1022C>A result in T107Y; in exon 9 conversion: 4156C>T and 4157A>T result in H478S, 4168G>A and 4169C>G result in A482S	3	1
ALLELE_DEFINITION	CYP2D6	All variants are annotated to the positive DNA strand	4	1
ALLELE_DEFINITION	CYP2D6	rsID are RefSNP accession ID number (http://www.ncbi.nlm.nih.gov/snp/).	5	1
ALLELE_DEFINITION	CYP2D6	The CYP2D6*1 allele is characterized by the absence of any sequence variations. Consequently, this allele cannot be identified by a SNP; rather CYP2D6*1 is assigned by default when no SNPs are detected during testing.	6	1
ALLELE_DEFINITION	CYP2D6	The CYP2D6*2 allele is typically characterized by two amino acid changes; both, however also occur in many other CYP2D6 alleles. Therefore, if an allele carries these two SNPs exclusively, it is designated CYP2D6*2. Interrogating for additional SNPs is the only way to distinguish CYP2D6*2 from other alleles (e.g., CYP2D6*17 and *41).	7	1
ALLELE_DEFINITION	CYP2D6	4180G>C is present on many allelic variants including functional and non-functional variants. Specifically, it has been found on some CYP2D6*4 subvariants. While some tests include this SNP, it cannot be utilized to identify an allelic variant with certainty.	8	1
ALLELE_DEFINITION	CYP2D6	An important caveat for all genotyping tests is that the decision to assign an allele a wild-type status is based upon a genotyping test that interrogates only the most common and already- proven sites of functional variation. It is always possible that a novel, previously undiscovered (and therefore un-interrogated) site of variation may confer loss-of-function in an individual, and thus lead to the rare possibility of a non-functional allele being erroneously called as wild-type.	9	1
ALLELE_DEFINITION	SLCO1B1	rsID=RefSNP accession ID number (http://www.ncbi.nlm.nih.gov/snp/)	0	1
ALLELE_DEFINITION	SLCO1B1	All variants are annotated to the positive DNA strand.	1	1
ALLELE_DEFINITION	CYP2D6	Content is accessed through the PharmVar API. HGVS and 'PharmVar-style' (accessible on the PharmVar website) positions may differ for indels in some instances which is most likely explained by differences in sequence alignments. Also, PharmVar displays single nucleotide insertions as 'ins' while the HGVS display is as duplications or 'dup' if the insertion is the same base as the prior base. The entries in the 'Free Text' field in row 2 reflect the default variant names on the CYP2D6 PharmVar page (https://www.pharmvar.org/gene/CYP2D6). Additional variant coordinates are consistent with the content displayed on the upper section of the 'Variant Positions' window which can be accessed by clicking on the variant of interest on the CYP2D6 PharmVar page.	10	1
ALLELE_DEFINITION	SLCO1B1	An important caveat for all genotyping tests is that the decision to assign an allele a "wild-type" status is based upon a genotyping test that interrogates only the most common and already-proven sites of functional variation. In human DNA, it is always possible that a new, previously undiscovered (and therefore un-interrogated) site of variation may confer loss-of-function in an individual, and thus lead to the rare possibility of a non-functional allele being erroneously called as "wild-type."	2	1
ALLELE_DEFINITION	SLCO1B1	Citations for assignment of function can be found at https://www.pharmgkb.org/page/slco1b1RefMaterials	3	1
FREQUENCY	CYP2B6	For full references see "references" tab.	0	1
GENE_CDS	CYP2C9	The phenotype is used to store an interpretation of the test result. This is a design decision that may differ among sites. Assignment of all Genotype/Phenotype Summaries based on diplotype is available on the 'Possible CYP2C19' Diplotype tab.	0	1
GENE_CDS	CYP2C9	A priority result is defined as a genetic test result that results in a change in drug, drug dose, or drug monitoring.	1	1
GENE_CDS	CYP2C9	The specific wording of the interpretive text may differ among sites.	2	1
GENE_CDS	CYP3A5	The coded diplotype/phenotype summary is used to store an interpretation of the test result. This is a design decision that may differ among sites. Assignment of all Genotype/Phenotype Summaries based on diplotype is available on the 'Possible CYP2C19' Diplotype tab.	0	1
GENE_CDS	CYP3A5	For this example, a priority result is defined as a genetic test result that results in a change in drug, drug dose, or drug monitoring.	1	1
GENE_CDS	CYP3A5	The specific wording of the interpretive text may differ among sites.	2	1
GENE_CDS	DPYD	The phenotype is used to store an interpretation of the test result. This is a design decision that may differ among sites.	0	1
GENE_CDS	DPYD	For this example, a priority result is defined as a genetic test result that results in a change in drug, drug dose, or drug monitoring.	1	1
GENE_CDS	DPYD	The specific wording of the interpretive text may differ among sites.	2	1
GENE_CDS	G6PD	For this example, a priority result is defined as a genetic test result that results in a change in drug, drug dose, or drug monitoring.	0	1
GENE_CDS	G6PD	The specific wording of the interpretive text may differ among sites.	1	1
GENE_CDS	HLA-A	The phenotype is used to store an interpretation of the test result. This is a design decision that may differ among sites.	0	1
GENE_CDS	HLA-A	For this example, a priority result is defined as a genetic test result that results in a change in drug, drug dose, or drug monitoring.	1	1
GENE_CDS	HLA-A	The specific wording of the interpretive text may differ among sites.	2	1
GENE_CDS	HLA-B	The phenotype is used to store an interpretation of the test result. This is a design decision that may differ among sites.	0	1
GENE_CDS	HLA-B	For this example, a priority result is defined as a genetic test result that results in a change in drug, drug dose, or drug monitoring.	1	1
GENE_CDS	HLA-B	The specific wording of the interpretive text may differ among sites.	2	1
GENE_CDS	MT-RNR1	The phenotype is used to store an interpretation of the test result. This is a design decision that may differ among sites.	0	1
GENE_CDS	MT-RNR1	For this example, a priority result is defined as a genetic test result that results in a change in drug, drug dose, or drug monitoring.	1	1
GENE_CDS	MT-RNR1	The specific wording of the interpretive text may differ among sites.	2	1
GENE_CDS	NAT2	The phenotype is used to store an interpretation of the test result. This is a design decision that may differ among sites.	0	1
GENE_CDS	NAT2	For this example, a priority result is defined as a genetic test result that results in a change in drug, drug dose, or drug monitoring.	1	1
GENE_CDS	NAT2	The specific wording of the interpretive text may differ among sites.	2	1
GENE_CDS	NUDT15	The phenotype is used to store an interpretation of the test result. This is a design decision that may differ among sites.	0	1
GENE_CDS	NUDT15	For this example, a priority result is defined as a genetic test result that results in a change in drug, drug dose, or drug monitoring.	1	1
GENE_CDS	NUDT15	The specific wording of the interpretive text may differ among sites.	2	1
GENE_CDS	RYR1	The phenotype is used to store an interpretation of the test result. This is a design decision that may differ among sites.	0	1
GENE_CDS	RYR1	For this example, a priority result is defined as a genetic test result that results in a change in drug, drug dose, or drug monitoring.	1	1
GENE_CDS	RYR1	The specific wording of the interpretive text may differ among sites.	2	1
GENE_CDS	SLCO1B1	The phenotype is used to store an interpretation of the test result. This is a design decision that may differ among sites.	0	1
GENE_CDS	SLCO1B1	For this example, a priority result is defined as a genetic test result that results in a change in drug, drug dose, or drug monitoring.	1	1
GENE_CDS	SLCO1B1	The specific wording of the interpretive text may differ among sites.	2	1
GENE_CDS	TPMT	The phenotype is used to store an interpretation of the test result. This is a design decision that may differ among sites.	0	1
GENE_CDS	TPMT	For this example, a priority result is defined as a genetic test result that results in a change in drug, drug dose, or drug monitoring.	1	1
GENE_CDS	TPMT	The specific wording of the interpretive text may differ among sites.	2	1
GENE_CDS	UGT1A1	The phenotype is used to store an interpretation of the test result. This is a design decision that may differ among sites.	0	1
GENE_CDS	UGT1A1	For this example, a priority result is defined as a genetic test result that results in a change in drug, drug dose, or drug monitoring.	1	1
GENE_CDS	UGT1A1	The specific wording of the interpretive text may differ among sites.	2	1
FREQUENCY	CYP2B6	See allele definition table (https://www.pharmgkb.org/page/cyp2b6RefMaterials) for allele definitions	3	1
FREQUENCY	CYP2B6	Because CYP2B6*1 is not genotyped directly, all alleles that are negative for a sequence variation are defaulted to a CYP2B6*1 assignment. The inferred frequency for CYP2B6*1 is calculated as: 1 - (sum of averaged variant allele frequencies).	4	1
FREQUENCY	CYP2C9	Average frequencies based on the reported frequencies in one or multiple studies.	1	1
FREQUENCY	CYP2C9	Based on the PharmGKB biogeographical groups https://www.pharmgkb.org/page/biogeographicalGroups	2	1
FREQUENCY	CYP2C9	See allele definition table (https://www.pharmgkb.org/page/cyp2c9RefMaterials) for allele definitions	3	1
FREQUENCY	CYP2C9	Because CYP2C9*1 is not genotyped directly, all alleles that are negative for a sequence variation are defaulted to a CYP2C9*1 assignment. The inferred frequency for CYP2C9*1 is calculated as: 1 - (sum of averaged variant allele frequencies).	4	1
FREQUENCY	CYP2D6	In the Sub-Saharan African group, presented data for Twesigomwe et al., 2022 PMID 36111505 is a combination of frequencies from PMID 36111505 and Wang et al. 2022 PMID 36294714. See the Methods and Caveats tab for how *1 frequencies are determined for this file.	0	1
FREQUENCY	CYP3A5	Average frequencies based on the reported frequencies in one or multiple studies.	1	1
FREQUENCY	CYP3A5	Based on the PharmGKB biogeographical groups https://www.pharmgkb.org/page/biogeographicalGroups	2	1
FREQUENCY	CYP3A5	See the Allele Definition Table at http://www.pharmgkb.org/cyp3a5RefMaterials for allele definitions	3	1
FREQUENCY	CYP3A5	Because CYP3A5*1 is not genotyped directly, all alleles that are negative for a sequence variation are defaulted to a CYP3A5*1 assignment. The inferred frequency for CYP3A5*1 is calculated as: 1 - (sum of averaged variant allele frequencies).	4	1
FREQUENCY	CYP4F2	For full references see "references" tab.	0	1
FREQUENCY	CYP4F2	Average frequencies based on the reported frequencies in one or multiple studies.	1	1
FREQUENCY	CYP4F2	Based on the PharmGKB biogeographical groups https://www.pharmgkb.org/page/biogeographicalGroups	2	1
FREQUENCY	CYP4F2	See allele definition table (https://www.pharmgkb.org/page/cyp4f2RefMaterials) for allele definitions	3	1
FREQUENCY	CYP4F2	Because CYP4F2*1 is not genotyped directly, all alleles that are negative for a sequence variation are defaulted to a CYP4F2*1 assignment. The inferred frequency for CYP4F2*1 is calculated as: 1 - (sum of averaged variant allele frequencies).	4	1
FREQUENCY	DPYD	Both variants in c.1129-5923C>G, c.1236G>A (HapB3) are listed with identical frequencies in 1000 Genomes	0	1
FREQUENCY	DPYD	For full references see "References" tab.	1	1
FREQUENCY	DPYD	Average frequencies based on the reported frequencies in one or multiple studies.	2	1
FREQUENCY	DPYD	Based on the PharmGKB biogeographical groups https://www.pharmgkb.org/page/biogeographicalGroups	3	1
FREQUENCY	DPYD	See allele definition table (https://www.pharmgkb.org/page/dpydRefMaterials) for allele definitions	4	1
FREQUENCY	G6PD	The allele frequency table was made by searching the gnomAD database v2.1.1 except for Cairo from v3.1.2	0	1
FREQUENCY	G6PD	Based on the PharmGKB biogeographical groups https://www.pharmgkb.org/page/biogeographicalGroups	1	1
FREQUENCY	G6PD	See allele definition table (https://www.pharmgkb.org/page/g6pdRefMaterials) for allele definitions	2	1
FREQUENCY	G6PD	Because B(reference) is not genotyped directly, all alleles that are negative for a sequence variation are defaulted to a B (reference) assignment. The inferred frequency for B(reference) is calculated as: 1 - (sum of averaged variant allele frequencies) but this may not be accurate since there are many variants with no known frequency.	3	1
FREQUENCY	G6PD	Note that gnomAD does not calculate haploytpe frequencies. Some haplotypes have frequencies in this spreadsheet if a unique allele in the haplotype has frequency information in gnomAD AND if the other variant in the haplotype is known to have normal function	4	1
FREQUENCY	G6PD	Note that some variants in this spreadsheet can either be found alone or in a haplotype (in combination with other variants). Therefore the frequency reported MAY NOT BE FOR THE VARIANT ALONE, BUT ALSO FOR THE VARIANT IF FOUND IN A HAPLOTYPE.	5	1
FREQUENCY	HLA-A	For full references see "References" tab.	0	1
FREQUENCY	HLA-A	Average frequencies based on the reported frequencies in one or multiple studies.	1	1
FREQUENCY	HLA-A	Based on the PharmGKB biogeographical groups https://www.pharmgkb.org/page/biogeographicalGroups	2	1
FREQUENCY	HLA-B	For full references see "References" tab.	0	1
FREQUENCY	HLA-B	aAverage frequencies based on the reported frequencies in one or multiple studies.	1	1
FREQUENCY	HLA-B	bBased on the PharmGKB biogeographical groups https://www.pharmgkb.org/page/biogeographicalGroups	2	1
FREQUENCY	MT-RNR1	For full references see "References" tab.	0	1
FREQUENCY	MT-RNR1	aAverage frequencies based on the reported frequencies in one or multiple studies.	1	1
FREQUENCY	MT-RNR1	bBased on the PharmGKB biogeographical groups https://www.pharmgkb.org/page/biogeographicalGroups	2	1
FREQUENCY	NUDT15	For full references see "References" tab.	0	1
FREQUENCY	NUDT15	Average frequencies based on the reported frequencies in one or multiple studies.	1	1
FREQUENCY	NUDT15	Based on the PharmGKB biogeographical groups https://www.pharmgkb.org/page/biogeographicalGroups	2	1
FREQUENCY	NUDT15	See allele definition table (https://www.pharmgkb.org/page/nudt15RefMaterials) for allele definitions	3	1
FREQUENCY	NUDT15	Because NUDT15*1 is not genotyped directly, all alleles that are negative for a sequence variation are defaulted to a NUDT15*1 assignment. The inferred frequency for NUDT15*1 is calculated as: 1 - (sum of averaged variant allele frequencies).	4	1
FREQUENCY	RYR1	For full references see "References" tab.	0	1
FREQUENCY	SLCO1B1	For full references see "References" tab.	0	1
FREQUENCY	SLCO1B1	Average frequencies based on the reported frequencies in one or multiple studies.	1	1
FREQUENCY	SLCO1B1	Based on the PharmGKB biogeographical groups https://www.pharmgkb.org/page/biogeographicalGroups	2	1
FREQUENCY	SLCO1B1	See allele definition table (https://www.pharmgkb.org/page/slco1b1RefMaterials) for allele definitions	3	1
FREQUENCY	SLCO1B1	Because SLCO1B1*1 is not genotyped directly, all alleles that are negative for a sequence variation are defaulted to a SLCO1B!*1 assignment. The inferred frequency for SLCO1B1*1 is calculated as: 1 - (sum of averaged variant allele frequencies).	4	1
FREQUENCY	TPMT	For full references see "References" tab.	0	1
FREQUENCY	TPMT	Average frequencies based on the reported frequencies in one or multiple studies.	1	1
FREQUENCY	TPMT	Based on the PharmGKB biogeographical groups https://www.pharmgkb.org/page/biogeographicalGroups	2	1
FREQUENCY	TPMT	See the Allele Definition Tables at https://www.pharmgkb.org/page/tpmtRefMaterials for allele definitions	3	1
FREQUENCY	TPMT	Because TPMT*1 is not genotyped directly, all alleles that are negative for a sequence variation are defaulted to a TPMT*1 assignment. The inferred frequency for TPMT*1 is calculated as: 1 - (sum of averaged variant allele frequencies).	4	1
FREQUENCY	UGT1A1	For full references see "References" tab.	0	1
FREQUENCY	UGT1A1	Average frequencies are based on the actual number of subjects with each allele as reported in one or multiple studies.	1	1
FREQUENCY	UGT1A1	Based on the PharmGKB biogeographical groups https://www.pharmgkb.org/page/biogeographicalGroups	2	1
FREQUENCY	UGT1A1	See allele definition table (https://www.pharmgkb.org/page/ugt1a1RefMaterials) for allele definitions	3	1
FREQUENCY	UGT1A1	Because UGT1A1*1 is not genotyped directly, all alleles that are negative for a sequence variation are defaulted to a UGT1A1*1 assignment. The inferred frequency for UGT1A1*1 is calculated as: 1 - (sum of averaged variant allele frequencies).	4	1
FREQUENCY	VKORC1	For full references see "References" tab.	0	1
FREQUENCY	VKORC1	Average frequencies based on the reported frequencies in one or multiple studies.	1	1
FREQUENCY	VKORC1	Based on the PharmGKB biogeographical groups https://www.pharmgkb.org/page/biogeographicalGroups	2	1
TEST_ALERT	RxNorm:704	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:704	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:343047	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:343047	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:83367	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:83367	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:2002	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:2002	"Clinical Pharmacist" could be a pharmacist, pharmacologist, or a clinician with pharmacogenetic expertise/training.	1	1
TEST_ALERT	RxNorm:2556	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:2556	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:2597	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:2597	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:32968	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:32968	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:27340	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:27340	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:3247	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:3247	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:816346	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:816346	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:816346	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:816346	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:3638	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:3638	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:195085	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:195085	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:3920	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:3920	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:321988	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:321988	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:41127	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:41127	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:42355	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:42355	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:72236	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:72236	Pharmacist, pharmacologist, or a clinician with pharmacogenetic expertise/training.	1	1
TEST_ALERT	RxNorm:5095	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:5095	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:5691	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:5691	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:6026	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:6026	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:17128	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:17128	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:17128	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:17128	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:6472	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:641	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:6472	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:6857	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:6857	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:7531	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:7531	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:7646	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:7646	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:7646	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:7646	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:26225	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:26225	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:32624	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:32624	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:40790	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:40790	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:40790	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:40790	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:32937	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:32937	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:8183	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:8183	Pharmacist, pharmacologist, or a clinician with pharmacogenetic expertise/training.	1	1
TEST_ALERT	RxNorm:8356	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:8356	Pharmacist, pharmacologist, or a clinician with pharmacogenetic expertise/training.	1	1
TEST_ALERT	RxNorm:861634	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:861634	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:42463	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:42463	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:301542	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:301542	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:36437	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:36437	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:36453	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:36453	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:36567	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:36567	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:10154	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:10154	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:42316	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:42316	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:10324	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:10324	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:37790	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:37790	Pharmacist, pharmacologist, or a clinician with pharmacogenetic expertise/training.	1	1
TEST_ALERT	RxNorm:10834	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:10834	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:121243	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:121243	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:121243	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:121243	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:190521	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:190521	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:519	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:519	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:641	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:7833	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:7833	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:7833	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:7833	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:1191	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:1191	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:1191	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:1191	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:38400	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:38400	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:38400	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:38400	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:1256	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:1256	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:194000	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:194000	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:140587	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:140587	Pharmacist, pharmacologist, or a clinician with pharmacogenetic expertise/training.	1	1
TEST_ALERT	RxNorm:2348	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:2348	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:2348	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:2348	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:2393	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:2393	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:2393	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:2393	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:2551	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:2551	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:2551	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:2551	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:2670	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:2670	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:3108	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:3108	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:3328	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:3328	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:3445	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:3445	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:3445	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:3445	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:3639	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:3639	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:3639	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:3639	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:4492	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:4492	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:4502	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:4502	Pharmacist, pharmacologist, or a clinician with pharmacogenetic expertise/training.	1	1
TEST_ALERT	RxNorm:4601	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:4601	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:4601	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:4601	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	ATC:D06AX07	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	ATC:D06AX07	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:4815	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:4815	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:4815	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:4815	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:5470	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:5470	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:5489	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:5489	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:5521	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:5521	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:5521	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:5521	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:5640	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:5640	Pharmacist, pharmacologist, or a clinician with pharmacogenetic expertise/training.	1	1
TEST_ALERT	RxNorm:6099	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:6099	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:20890	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:20890	Pharmacist, pharmacologist, or a clinician with pharmacogenetic expertise/training.	1	1
TEST_ALERT	RxNorm:6572	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:6572	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:6572	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:6572	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:41493	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:41493	Pharmacist, pharmacologist, or a clinician with pharmacogenetic expertise/training.	1	1
TEST_ALERT	RxNorm:103	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:103	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:6878	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:6878	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:6918	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:6918	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:7240	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:7240	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:7240	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:7240	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:7299	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:7299	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:7337	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:7337	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:7454	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:7454	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:7517	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:7517	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:7517	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:7517	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:7623	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:7623	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:7623	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:7623	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:7934	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:7934	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:1011650	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:1011650	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:8120	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:8120	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:8120	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:8120	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:2049549	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:2049549	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:8687	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:8687	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:8687	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:8687	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:9071	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:9071	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:9071	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:9071	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:283821	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:283821	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:NA	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:NA	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:10109	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:10109	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:10171	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:10171	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:10171	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:10171	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:10178	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:10178	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:10178	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:10178	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:10831	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:10831	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:10831	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:10831	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:10184	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:10184	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:10184	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:10184	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:9524	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:9524	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:9524	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:9524	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:10207	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:10207	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:10207	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:10207	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:2054023	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:2054023	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:10485	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:10485	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:10627	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:10627	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:10635	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:10635	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:10635	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:10635	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:10638	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:10638	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:10689	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:10689	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:27392	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:27392	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:39786	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:39786	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:1151	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:1151	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:1151	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:1151	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:11258	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:11258	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:11258	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:11258	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:1455099	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:1455099	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
\.


--
-- Data for Name: flyway_schema_history; Type: TABLE DATA; Schema: cpic; Owner: -
--

COPY cpic.flyway_schema_history (installed_rank, version, description, type, script, checksum, installed_by, installed_on, execution_time, success) FROM stdin;
1	1	Initial bootstrap	SQL	V1__Initial_bootstrap.sql	1343833882	cpic	2020-09-30 21:02:41.398674	17646	t
2	2	initial data	SQL	V2__initial_data.sql	1569953039	cpic	2020-09-30 21:03:00.181244	1464	t
3	3	views	SQL	V3__views.sql	1637573145	cpic	2020-09-30 21:03:02.68466	2906	t
4	4	flow charts	SQL	V4__flow_charts.sql	-461764197	cpic	2020-09-30 21:03:06.637242	3674	t
5	6	nsaid release	SQL	V6__nsaid_release.sql	1899796322	cpic	2020-09-30 21:03:11.349979	2479	t
6	7	nsaid pair data	SQL	V7__nsaid_pair_data.sql	-1759040576	cpic	2020-09-30 21:03:14.862537	1507	t
7	8	data progress view	SQL	V8__data_progress_view.sql	-583739949	cpic	2020-09-30 21:03:17.405314	325	t
8	9	file view	SQL	V9__file_view.sql	-435728782	cpic	2020-09-30 21:03:18.784115	320	t
9	10	pair data update	SQL	V10__pair_data_update.sql	1561416759	cpic	2020-09-30 21:03:20.133162	720	t
10	11	guideline in drug model	SQL	V11__guideline_in_drug_model.sql	1721141764	cpic	2020-09-30 21:03:21.898691	476	t
11	12	pair data update	SQL	V12__pair_data_update.sql	-1970090295	cpic	2020-09-30 21:03:23.402028	233	t
12	13	add publications	SQL	V13__add_publications.sql	1291951866	cpic	2020-09-30 21:03:24.679997	320	t
13	14	add highlighted publications	SQL	V14__add_highlighted_publications.sql	759335679	cpic	2020-09-30 21:03:26.044179	399	t
14	15	pair data update	SQL	V15__pair_data_update.sql	81113836	cpic	2020-09-30 21:03:27.481903	243	t
15	16	update ibuprofen ATC	SQL	V16__update_ibuprofen_ATC.sql	1407599949	cpic	2020-09-30 21:03:28.777477	243	t
16	18	allele status lookup	SQL	V18__allele_status_lookup.sql	-859499970	cpic	2020-09-30 21:03:30.070317	482	t
17	19	new publication	SQL	V19__new_publication.sql	-1342471317	cpic	2020-09-30 21:03:31.581321	315	t
18	20	update sequence IDs	SQL	V20__update_sequence_IDs.sql	-75396910	cpic	2020-09-30 21:03:32.939966	480	t
19	21	recommendation lookup fn	SQL	V21__recommendation_lookup_fn.sql	-1422255981	cpic	2020-09-30 21:03:34.466215	478	t
20	22	ppi release	SQL	V22__ppi_release.sql	-1608844545	cpic	2020-09-30 21:03:35.973984	885	t
21	23	helpful views	SQL	V23__helpful_views.sql	1737227498	cpic	2020-09-30 21:03:37.894656	1362	t
22	24	new drug flowcharts	SQL	V24__new_drug_flowcharts.sql	426101726	cpic	2020-09-30 21:03:40.286768	888	t
23	25	phenytoin guideline update	SQL	V25__phenytoin_guideline_update.sql	-746232628	cpic	2020-09-30 21:03:42.235826	481	t
24	26	validate pair pmids	SQL	V26__validate_pair_pmids.sql	-1806818774	cpic	2020-09-30 21:03:43.755407	240	t
25	27	reference allele	SQL	V27__reference_allele.sql	849245471	cpic	2020-09-30 21:03:45.03582	1701	t
26	\N	apply permissions	SQL	R__apply_permissions.sql	-1445996752	cpic	2020-09-30 21:03:47.781042	1352	t
27	28	more allele frequency	SQL	V28__more_allele_frequency.sql	805701621	cpic	2020-10-06 04:45:31.882019	65	t
28	29	gene notes on diplotype	SQL	V29__gene_notes_on_diplotype.sql	-32272162	cpic	2020-10-06 04:45:31.979835	39	t
29	30	fix diplotype note column name	SQL	V30__fix_diplotype_note_column_name.sql	-1780194441	cpic	2020-10-06 20:33:55.825135	12	t
30	31	structural variant alleles	SQL	V31__structural_variant_alleles.sql	907385290	cpic	2020-10-21 16:33:11.171586	21	t
31	32	more notes	SQL	V32__more_notes.sql	946380705	cpic	2020-10-26 04:13:26.606463	33	t
32	33	remove allele frequency	SQL	V33__remove_allele_frequency.sql	370457724	cpic	2020-10-29 02:34:55.945477	28	t
33	34	add constraints to publication	SQL	V34__add_constraints_to_publication.sql	1822736403	cpic	2020-12-07 19:33:55.270759	86	t
34	35	opioid release	SQL	V35__opioid_release.sql	-334675632	cpic	2021-01-08 00:30:17.865038	51	t
35	36	update allele view	SQL	V36__update_allele_view.sql	-926799802	cpic	2021-01-15 23:54:12.278947	96	t
36	37	remove unused column	SQL	V37__remove_unused column.sql	-2122981860	cpic	2021-03-25 17:42:36.558878	134	t
37	38	gene urls	SQL	V38__gene_urls.sql	1563545318	cpic	2021-03-25 17:42:36.742551	62	t
38	\N	apply permissions	SQL	R__apply_permissions.sql	-575065814	cpic	2021-03-25 17:42:36.82488	28	t
39	39	guideline summary view	SQL	V39__guideline_summary_view.sql	480060255	cpic	2021-03-26 20:19:53.149371	58	t
40	\N	apply permissions	SQL	R__apply_permissions.sql	-1861354715	cpic	2021-03-26 20:19:53.225004	31	t
41	40	fix flowchart urls	SQL	V40__fix_flowchart_urls.sql	-1456884835	cpic	2021-05-11 18:22:43.25079	46	t
43	42	aminoglycosides guideline	SQL	V42__aminoglycosides_guideline.sql	540949488	cpic	2021-06-14 04:40:37.690857	93	t
44	43	seq loc unique key	SQL	V43__seq_loc_unique_key.sql	-1638696174	cpic	2021-06-14 04:40:37.808891	52	t
45	44	functionmethods	SQL	V44__functionmethods.sql	2079604482	cpic	2021-06-29 15:43:53.422219	16	t
46	45	sequence location position	SQL	V45__sequence_location_position.sql	1314277241	cpic	2021-07-09 21:30:29.833003	102	t
47	46	fix dbsnpid column	SQL	V46__fix_dbsnpid_column.sql	-1850897598	cpic	2021-08-05 17:38:43.759722	21	t
48	47	guideline fns	SQL	V47__guideline_fns.sql	-1198346012	cpic	2021-08-18 22:14:26.14922	30	t
49	48	update guideline allele fn	SQL	V48__update_guideline_allele_fn.sql	-1854568090	cpic	2021-09-09 21:03:26.214156	30	t
50	49	fix allele findings	SQL	V49__fix_allele_findings.sql	976892510	cpic	2021-09-09 21:03:26.268771	65	t
51	50	fix IFNL3 lookup	SQL	V50__fix_IFNL3_lookup.sql	119727388	cpic	2021-10-13 17:22:27.82421	9	t
52	51	fix guideline allele fn	SQL	V51__fix_guideline_allele_fn.sql	798068262	cpic	2021-11-10 05:57:09.346894	62	t
53	52	recommendation alleles view	SQL	V52__recommendation_alleles_view.sql	-1879594301	cpic	2021-12-07 15:59:50.932388	98	t
54	\N	apply permissions	SQL	R__apply_permissions.sql	-1576403970	cpic	2021-12-07 15:59:51.080556	20	t
55	53	statins guideline	SQL	V53__statins_guideline.sql	-374639719	cpic	2022-02-16 23:10:42.374259	18	t
56	54	publication index	SQL	V54__publication_index.sql	-1084867310	cpic	2022-02-18 22:16:35.644864	11	t
57	55	allele frequency cache	SQL	V55__allele_frequency_cache.sql	778761699	cpic	2022-03-09 23:20:36.042025	13	t
58	56	gene legacy names	SQL	V56__gene_legacy_names.sql	-442391864	cpic	2022-03-17 23:13:23.411535	13	t
59	57	pgkb recs fn update	SQL	V57__pgkb_recs_fn_update.sql	415609266	cpic	2022-06-10 14:24:09.906199	22	t
42	41	publication files	SQL	V41__publication_files.sql	389573953	cpic	2021-05-11 18:22:43.398622	319	t
60	\N	apply permissions	DELETE	R__apply_permissions.sql	-1576403970	cpic	2022-08-16 07:29:30.595272	0	t
61	58	stats table	SQL	V58__stats_table.sql	1603923816	cpic	2022-08-16 07:35:43.159887	60	t
62	59	remove allele guideline	SQL	V59__remove_allele_guideline.sql	-1144551837	cpic	2022-09-14 17:55:53.477071	21	t
63	60	reference allele	SQL	V60__reference_allele.sql	1296637883	cpic	2022-09-14 17:55:53.52649	26	t
64	61	G6PD guideline prep	SQL	V61__G6PD_guideline_prep.sql	1983975991	cpic	2022-09-14 17:55:53.577532	28	t
65	62	G6PD flow charts	SQL	V62__G6PD_flow_charts.sql	626814934	cpic	2022-09-22 16:42:28.143006	29	t
66	63	fosphenytoin flow chart	SQL	V63__fosphenytoin_flow_chart.sql	1952328724	cpic	2022-09-30 13:34:29.608278	28	t
67	64	recommendation flags	SQL	V64__recommendation_flags.sql	-797174188	cpic	2023-02-27 19:42:13.143746	42	t
68	65	frequency flags	SQL	V65__frequency_flags.sql	-477833361	cpic	2023-03-23 11:54:36.147354	42	t
69	66	ssri snri guideline	SQL	V66__ssri_snri_guideline.sql	-1949888557	cpic	2023-04-12 19:43:47.434594	34	t
70	67	frequency view fix	SQL	V67__frequency_view_fix.sql	-1816979743	cpic	2023-09-01 14:42:15.154823	41	t
71	68	fix function definitions	SQL	V68__fix_function_definitions.sql	1243132888	cpic	2024-01-12 20:33:40.207106	11	t
72	69	change log releases	SQL	V69__change_log_releases.sql	1272931372	cpic	2024-05-09 15:03:57.003783	276	t
73	70	fix allele freq view	SQL	V70__fix_allele_freq_view.sql	-957778206	cpic	2024-10-03 15:13:15.938037	9	t
74	71	fix guideline summary view	SQL	V71__fix_guideline_summary_view.sql	-1334280856	cpic	2025-03-07 16:21:39.906989	8	t
75	72	gene cds changelog	SQL	V72__gene_cds_changelog.sql	1161542228	cpic	2025-08-13 13:08:11.731509	7	t
76	73	clinpgx guideline update	SQL	V73__clinpgx_guideline_update.sql	-1024347267	cpic	2025-08-13 13:08:11.764363	15	t
77	74	supplemental file cleanup	SQL	V74__supplemental_file_cleanup.sql	822347170	cpic	2025-08-21 13:23:06.297301	15	t
78	75	hydrazaline guideline	SQL	V75__hydrazaline_guideline.sql	1311712376	cpic	2025-09-08 15:29:54.084279	6	t
79	76	rename summary level	SQL	V76__rename_summary_level.sql	-1125398572	cpic	2026-03-13 12:58:42.488466	8	t
80	77	pharmgkb rename	SQL	V77__pharmgkb_rename.sql	1687555689	cpic	2026-03-13 12:58:42.52321	13	t
\.


--
-- Data for Name: gene; Type: TABLE DATA; Schema: cpic; Owner: -
--

COPY cpic.gene (symbol, chr, genesequenceid, proteinsequenceid, chromosequenceid, mrnasequenceid, hgncid, ncbiid, ensemblid, clinpgxid, frequencymethods, lookupmethod, version, notesondiplotype, url, functionmethods, notesonallelenaming, includephenotypefrequencies, includediplotypefrequencies) FROM stdin;
ERCC1	chr19	NG_015839	NP_001974	\N	\N	HGNC:3433	2067	ENSG00000012061	PA155	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
POLG	chr15	NG_008218	NP_002684	\N	\N	HGNC:9179	5428	ENSG00000140521	PA33500	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
ASS1	chr9	NG_011542	NP_000041	\N	\N	HGNC:758	445	ENSG00000130707	PA162376926	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
DRD2	chr11	NG_008841	NP_000786	\N	\N	HGNC:3023	1813	ENSG00000149295	PA27478	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
ATIC	chr2	NG_013002	NP_004035	\N	\N	HGNC:794	471	ENSG00000138363	PA25094	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
APOE	chr19	NG_007084	NP_000032	\N	\N	HGNC:613	348	ENSG00000130203	PA55	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
GSTM1	chr1	NG_009246	NP_000552	\N	\N	HGNC:4632	2944	ENSG00000134184	PA182	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
F5	chr1	NG_011806	NP_000121	\N	\N	HGNC:3542	2153	ENSG00000198734	PA159	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
CYB5R3	chr22	NG_012194	NP_000389	\N	\N	HGNC:2873	1727	ENSG00000100243	PA27331	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
CHRNA3	chr15	NG_016143	NP_000734	\N	\N	HGNC:1957	1136	ENSG00000080644	PA113	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
HMGCR	chr5	NG_011449	NP_000850	\N	\N	HGNC:5006	3156	ENSG00000113161	PA189	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
CRHR1	chr17	NG_009902	NP_004373	\N	\N	HGNC:2357	1394	ENSG00000120088	PA26874	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
ITPA	chr20	NG_012093	NP_258412	\N	\N	HGNC:6176	3704	ENSG00000125877	PA29973	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
MC4R	chr18	NG_016441	NP_005903	\N	\N	HGNC:6932	4160	ENSG00000166603	PA30676	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
COQ2	chr4	NG_015825	NP_056512	\N	\N	HGNC:25223	27235	ENSG00000173085	PA142672084	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
HTR2C	chrX	NG_012082	NP_000859	\N	\N	HGNC:5295	3358	ENSG00000147246	PA194	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
OTC	chrX	NG_008471	NP_000522	\N	\N	HGNC:8512	5009	ENSG00000036473	PA32840	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
MTRR	chr5	NG_008856	NP_002445	\N	\N	HGNC:7473	4552	ENSG00000124275	PA31277	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
LPA	chr6	NG_016147	NP_005568	\N	\N	HGNC:6667	4018	ENSG00000198670	PA30432	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
NAT1	chr8	NG_012245	NP_000653	\N	\N	HGNC:7645	9	ENSG00000171428	PA17	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
CPS1	chr2	NG_008285	NP_001866	\N	\N	HGNC:2323	1373	ENSG00000021826	PA26840	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
EGF	chr4	NG_011441	NP_001954	\N	\N	HGNC:3229	1950	ENSG00000138798	PA27664	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
DYNC2H1	chr11	NG_016423	NP_001368	\N	\N	HGNC:2962	79659	ENSG00000187240	PA27433	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
GNB3	chr12	NG_009100	NP_002066	\N	\N	HGNC:4400	2784	ENSG00000111664	PA176	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
SEMA3C	chr7	\N	NP_006370	\N	\N	HGNC:10725	10512	ENSG00000075223	PA35647	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
KIF6	chr6	\N	NP_659464	\N	\N	HGNC:21202	221458	ENSG00000164627	PA134920075	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
CCHCR1	chr6	\N	NP_061925	\N	\N	HGNC:13930	54535	ENSG00000204536	PA134942738	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
FCGR3A	chr1	NG_009066	NP_000560	\N	\N	HGNC:3619	2214	ENSG00000203747	PA28065	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
NAGS	chr17	NG_008106	NP_694551	\N	\N	HGNC:17996	162417	ENSG00000161653	PA134968729	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
LDLR	chr19	NG_009060	NP_000518	\N	\N	HGNC:6547	3949	ENSG00000130164	PA227	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
ASL	chr7	NG_009288	NP_000039	\N	\N	HGNC:746	435	ENSG00000126522	PA25046	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
HPRT1	chrX	NG_012329	NP_000185	\N	\N	HGNC:5157	3251	ENSG00000165704	PA29427	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
ANKK1	chr11	NG_012976	NP_848605	\N	\N	HGNC:21027	255239	ENSG00000170209	PA134872551	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
XPC	chr3	NG_011763	NP_004619	\N	\N	HGNC:12816	7508	ENSG00000154767	PA37413	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
ADRB2	chr5	NG_016421	NP_000015	\N	\N	HGNC:286	154	ENSG00000169252	PA39	\N	PHENOTYPE	3	\N	https://cpicpgx.org/gene/adrb2/	\N	\N	t	t
ADRA2C	\N	\N	\N	\N	\N	HGNC:283	152	ENSG00000184160	\N	\N	PHENOTYPE	22	\N	https://cpicpgx.org/gene/adra2c/	\N	\N	t	t
CALU	chr7	\N	NP_001210	\N	\N	HGNC:1458	813	ENSG00000128595	\N	\N	PHENOTYPE	110	\N	\N	\N	\N	t	t
CES1	chr16	NG_012057	NP_001257	\N	\N	HGNC:1863	1066	ENSG00000198848	\N	\N	PHENOTYPE	109	\N	\N	\N	\N	t	t
FKBP5	chr6	NG_012645	NP_004108	\N	\N	HGNC:3721	2289	ENSG00000096060	PA28162	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
ACE	chr17	NG_011648	NP_000780	\N	\N	HGNC:2707	1636	ENSG00000159640	PA139	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
TXNRD2	chr22	NG_011835	NP_006431	\N	\N	HGNC:18155	10587	ENSG00000184470	PA38302	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
GBA	chr1	NG_009783	NP_000148	\N	\N	HGNC:4177	2629	ENSG00000177628	PA28591	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
HLA-DRB1	chr6	NG_002392	NP_002115	\N	\N	HGNC:4948	3123	ENSG00000196126	PA35072	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
CETP	chr16	NG_008952	NP_000069	\N	\N	HGNC:1869	1071	ENSG00000087237	PA108	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
UGT1A4	chr2	NG_002601	NP_009051	\N	\N	HGNC:12536	54657	ENSG00000244474	PA37179	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
TP53	chr17	NG_017013	NP_000537	\N	\N	HGNC:11998	7157	ENSG00000141510	PA36679	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
PRKCA	chr17	NG_012206	NP_002728	\N	\N	HGNC:9393	5578	ENSG00000154229	PA33759	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
TCF7L2	chr10	NG_012631	NP_110383	\N	\N	HGNC:11641	6934	ENSG00000148737	PA36394	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
ADD1	chr4	NG_012037	NP_001110	\N	\N	HGNC:243	118	ENSG00000087274	PA31	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
TMEM43	chr3	NG_008975	NP_077310	\N	\N	HGNC:28472	79188	ENSG00000170876	PA134871907	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
SOD2	chr6	NG_008729	NP_000627	\N	\N	HGNC:11180	6648	ENSG00000112096	PA36017	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
SERPINC1	chr1	NG_012462	NP_000479	\N	\N	HGNC:775	462	ENSG00000117601	PA35026	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
TNF	chr6	NG_007462	NP_000585	\N	\N	HGNC:11892	7124	ENSG00000232810	PA435	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
C11orf65	chr11	\N	NP_689800	\N	\N	HGNC:28519	160140	ENSG00000166323	PA144596484	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
HAS3	chr16	\N	NP_005320	\N	\N	HGNC:4820	3038	ENSG00000103044	PA29196	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
SLC47A2	chr17	\N	NP_001093116	\N	\N	HGNC:26439	146802	ENSG00000180638	PA162403847	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
CBR3	chr21	\N	NP_001227	\N	\N	HGNC:1549	874	ENSG00000159231	PA26122	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
NT5C2	chr10	\N	NP_036361	\N	\N	HGNC:8022	22978	ENSG00000076685	PA31801	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
NEDD4L	chr18	\N	NP_056092	\N	\N	HGNC:7728	23327	ENSG00000049759	PA31534	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
CYB5R1	chr1	\N	NP_057327	\N	\N	HGNC:13397	51706	ENSG00000159348	PA134979668	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
SLC28A3	chr9	\N	NP_071410	\N	\N	HGNC:16484	64078	ENSG00000197506	PA426	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
FDPS	chr1	\N	NP_001995	\N	\N	HGNC:3631	2224	ENSG00000160752	PA28075	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
PTGFR	chr1	\N	NP_000950	\N	\N	HGNC:9600	5737	ENSG00000122420	PA290	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
KCNIP4	chr4	\N	NP_671711	\N	\N	HGNC:30083	80333	ENSG00000185774	PA134893552	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
HLA-DQA1	chr6	\N	NP_002113	\N	\N	HGNC:4942	3117	ENSG00000196735	PA35066	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
ABCC4	chr13	\N	NP_005836	\N	\N	HGNC:55	10257	ENSG00000125257	PA397	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
ABL2	chr1	\N	NP_005149	\N	\N	HGNC:77	27	ENSG00000143322	PA24414	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
UGT2B15	chr4	\N	NP_001067	\N	\N	HGNC:12546	7366	ENSG00000196620	PA37188	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
YEATS4	chr12	\N	NP_006521	\N	\N	HGNC:24859	8089	ENSG00000127337	PA134992686	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
TANC1	chr2	\N	NP_203752	\N	\N	HGNC:29364	85461	ENSG00000115183	PA142670838	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
CRHR2	chr7	\N	NP_001874	\N	\N	HGNC:2358	1395	ENSG00000106113	PA26875	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
CYB5R2	chr11	\N	NP_057313	\N	\N	HGNC:24376	51700	ENSG00000166394	PA142672060	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
XRCC1	chr19	\N	NP_006288	\N	\N	HGNC:12828	7515	ENSG00000073050	PA369	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
COL22A1	chr8	\N	NP_690848	\N	\N	HGNC:22989	169044	ENSG00000169436	PA134914705	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
CYB5R4	chr6	\N	NP_057314	\N	\N	HGNC:20147	51167	ENSG00000065615	PA134904907	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
C8orf34	chr8	\N	NP_443190	\N	\N	HGNC:30905	116328	ENSG00000165084	PA142672353	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
ADORA2A	chr22	\N	NP_000666	\N	\N	HGNC:263	135	ENSG00000128271	PA24584	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
OPRM1	chr6	NG_021208	NP_000905	\N	\N	HGNC:8156	4988	ENSG00000112038	\N	\N	PHENOTYPE	103	\N	https://cpicpgx.org/gene/oprm1/	\N	\N	t	t
ADRB1	\N	\N	\N	\N	\N	HGNC:285	153	ENSG00000043591	\N	\N	PHENOTYPE	108	\N	https://cpicpgx.org/gene/adrb1/	\N	\N	t	t
PTGS1	chr9	\N	NP_000953	\N	\N	HGNC:9604	5742	ENSG00000095303	\N	\N	PHENOTYPE	110	\N	\N	\N	\N	t	t
NAT2	chr8	NG_012246.1	NP_000006.2	NC_000008.11	NM_001042351.2	HGNC:7646	10	ENSG00000156006	\N	\N	PHENOTYPE	129	\N	\N	\N	Common name	t	t
RYR1	chr19	NG_008866.1	NP_000531.2	NC_000019.10	NM_000540.2	HGNC:10483	6261	ENSG00000196218	\N	Methods\n\nTable includes variants based on an update of the CPIC guideline for potent volatile anesthetic agents and succinylcholine. The guideline update includes the published list of RYR1 variants (supplemental table S2), which are evaluated by the ClinGen malignant hyperthermia susceptibility (MHS) variant curation expert panel and classified for RYR1-related malignant hyperthermia susceptibility based on specified ACMG/AMP criteria (PMID 35849058).\n\ngnomAD v2.1.1 was queried with the variant positions or rsIDs.\ngnomAD population description - PharmGKB biogeographical group mapping:\nAfrican/African American - Sub-Saharan African\nSouth Asian - Central/South Asian\nLatino/Admixed American - Latino\nEast Asian - East Asian\nNon-Finnish European - European\nAshkenazi Jewish - Near Eastern\n\nCaveats to estimated allele, frequencies:\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details, including the definitions of each group, can be found at https://www.pharmgkb.org/page/biogeographicalGroups. We strongly recommend that users use either the publication or the PharmGKB link provided to familiarize themselves with the grouping system before using these allele frequencies. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.	PHENOTYPE	423	\N	https://cpicpgx.org/gene/ryr1/	\N	Common name	f	f
CYP2A7P1	chr19	NG_000008	\N	\N	\N	HGNC:2612	1550	ENSG00000213908	\N	\N	PHENOTYPE	110	\N	\N	\N	\N	t	t
FLOT1	chr6	\N	NP_005794	\N	\N	HGNC:3757	10211	ENSG00000137312	\N	\N	PHENOTYPE	110	\N	\N	\N	\N	t	t
GRIK4	chr11	\N	NP_055434	\N	\N	HGNC:4582	2900	ENSG00000149403	\N	\N	PHENOTYPE	110	\N	\N	\N	\N	t	t
GRK4	\N	\N	\N	\N	\N	HGNC:4543	2868	ENSG00000125388	\N	\N	PHENOTYPE	22	\N	https://cpicpgx.org/gene/grk4/	\N	\N	t	t
GRK5	\N	\N	\N	\N	\N	HGNC:4544	2869	ENSG00000198873	\N	\N	PHENOTYPE	108	\N	https://cpicpgx.org/gene/grk5/	\N	\N	t	t
HLA-C	chr6	NG_002397	NP_002108	\N	\N	HGNC:4933	3107	ENSG00000204525	\N	\N	PHENOTYPE	109	\N	\N	\N	\N	t	t
HLA-DPB1	chr6	\N	NP_002112	\N	\N	HGNC:4940	3115	ENSG00000223865	\N	\N	PHENOTYPE	110	\N	\N	\N	\N	t	t
HTR1A	chr5	\N	NP_000515	\N	\N	HGNC:5286	3350	ENSG00000178394	\N	\N	PHENOTYPE	110	\N	\N	\N	\N	t	t
IFNL4	chr19	\N	\N	\N	\N	HGNC:44480	101180976	ENSG00000272395	\N	\N	PHENOTYPE	112	\N	https://cpicpgx.org/gene/ifnl/	\N	\N	t	t
LTC4S	chr5	\N	NP_665874	\N	\N	HGNC:6719	4056	ENSG00000213316	\N	\N	PHENOTYPE	110	\N	\N	\N	\N	t	t
HLA-A	chr6	NG_002398	NP_002107	\N	\N	HGNC:4931	3105	ENSG00000206503	\N	Methods\n\nThe allele frequency table was made by searching the PubMed® database (1995 to September 2019). The following criteria were used for HLA-A: (HLA-A) AND (allele OR frequency). In addition, reports were also identified from citations by others or review articles. Studies were considered for inclusion in the HLA-A frequency table if: (1) the ethnicity of the population was clearly indicated, (2) either allele frequencies or genotype frequencies were reported, (3) the method by which the genes were genotyped was indicated, (4) the sample population consisted of at least 50 individuals with a few exceptions (e.g., smaller cohorts that were part of larger studies) and (5) the study represented an original publication (no reviews or meta-analyses). Allele frequencies reported in phase 3 1000 Genomes (http://browser.1000genomes.org/index.html) and from allelefrequencies.net (https://www.allelefrequencies.net) were also included .\nCaveats to estimated allele frequencies:\n\nSampling. Allele frequencies collected by CPIC for the supplemental tables are based on published literature reports which typically study small groups of people based on a geographic location (e.g. Malaysia, Berlin, Cairo). Almost no studies use genetic markers to estimate ancestry. Manuscripts are often focused on a specific phenotype (e.g. disease) or study only individuals taking a particular drug. Such samples would not be considered a random sample of the general population. Another consideration is that sample size is important, and PGx studies are typically not large. The frequencies collected from these studies are then used to estimate general estimates of entire ethnic population allele frequencies. Therefore, frequencies from larger groups of subjects and frequencies averaged from many sample populations probably result in better estimates.\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details, including the definitions of each group, can be found at https://www.pharmgkb.org/page/biogeographicalGroups. We strongly recommend that users use either the publication or the PharmGKB link provided to familiarize themselves with the grouping system before using these allele frequencies. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.	ALLELE_STATUS	215	\N	https://cpicpgx.org/gene/hla/	\N	\N	f	f
DPYD	chr1	NG_008807.2	NP_000101.2	NC_000001.11	NM_000110.4	HGNC:3012	282617	ENSG00000188641	\N	Methods:\nThe DPYD frequency table was created using data from ExAC (http://exac.broadinstitute.org/) and the 1000 Genomes project (http://www.ensembl.org/Homo_sapiens/Info/Index).\nThe average allele frequencies by race were calculated by taking the number with the variant in all studies divided by the total number of individuals tested for the variant in all studies.\nAll nucleotide changes are according to reference sequence NM_000110.3 and all protein changes are according to reference sequence NP_000101.2\nCaveats\nIf 1000 Genomes and/or ExAC did not return any frequency data for a given variant, cells were left blank\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details can be found at https://www.pharmgkb.org/page/biogeographicalGroups. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.\n\n\n\n\n\n\n\n	ACTIVITY_SCORE	432	The DPYD phenotype is assigned using a gene activity score (DPYD-AS; based on the DPYD Allele Functionality Table), calculated as the sum of the two DPYD variants with the lowest variant activity value. Briefly, carriers of two no function variants (DPYD-AS: 0) OR one decreased function variant (DPD-AS: 0.5) are classified as DPYD poor metabolizers; carriers of two decreased function variants OR carriers of only one no function variant (DPYD-AS: 1) OR carriers of only one decreased function variant (DPYD-AS: 1.5) are considered DPYD intermediate metabolizers , and those with only normal function variants are classified as DPYD normal metabolizers (DPYD-AS: 2). If two decreased/no function variants are present, each decreased/no function variant is considered to be on a different gene copy. Irrespective of the presence of decreased/no function variants, patients may carry multiple normal function variants. As an individual only carries a maximum of two fully functional DPYD copies, common normal function variants may be located on the same gene copy as other normal function variants or decreased/no function variants.	https://cpicpgx.org/gene/dpyd/	\N	Legacy Name/Class	f	f
NUDT15	chr13	NG_047021.1	NP_060753.1	NC_000013.11	NM_001042351.2	HGNC:23063	55270	ENSG00000136159	\N	The allele frequency table was made by searching the PubMed® database (no start date to 1/2018). Allele frequencies reported in the gnomAD browser (http://gnomad.broadinstitute.org/ - exomes and genomes) and ensembl (grch37.ensembl.org - exomes or genomes) were also included. URLs are included in the "PMID" column.\n\nDiplotype and phenotype frequencies were estimated using the equation describing Hardy Weinberg equilibrium based on reported allele frequencies.\n\nCaveats to estimated allele, diplotype and phenotype frequencies:\n\nSampling. Allele frequencies collected by CPIC for the supplemental tables are based on published literature reports which typically study small groups of people based on a geographic location (e.g. Malaysia, Berlin, Cairo). Almost no studies use genetic markers to estimate ancestry. Manuscripts are often focused on a specific phenotype (e.g. disease) or study only individuals taking a particular drug. Such samples would not be considered a random sample of the general population. Another consideration is that sample size is important, and PGx studies are typically not large. The frequencies collected from these studies are then used to estimate general estimates of entire ethnic population allele frequencies. Therefore, frequencies from larger groups of subjects and frequencies averaged from many sample populations probably result in better estimates.\n\nEstimation of *1 frequency. In general, there are no population studies that test for all known variant alleles. Because *1 is not genotyped directly in many studies, all alleles that are negative for a sequence variation are defaulted to a *1 assignment. The inferred frequency for *1 is estimated as: 100 - (sum of averaged variant allele frequencies). For genes where many alleles are not tested for in any population, and frequency of 'common' alleles is not well documented in many understudied populations (Oceania, South Asian, Latino), the *1 frequency will deviate even more from true values.\n\nDiplotype/Phenotype frequency estimates. Diplotype and phenotype frequencies were estimated using the equation describing Hardy Weinberg equilibrium based on reported allele frequencies. When calculating diplotype frequencies from these allele frequencies, the margin of error is compounded based on the margin of error on each allele in the diplotype. So, the margin of error will necessarily increase for diplotype frequency estimates compared to allele frequency estimates. For allele frequencies with already large margins of error due to small and non-random sampling, the diplotype margin of error could potentially be quite large. On the other hand, for well-studied alleles, the margin of error is likely low.\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details can be found at https://www.pharmgkb.org/page/biogeographicalGroups. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.	PHENOTYPE	423	\N	https://cpicpgx.org/gene/nudt15/	\N	Common name	t	t
MT-RNR1	chrM	NG_042193.1	NP_000101.2	NC_012920.1	NM_001042351.2	HGNC:7470	4549	ENSG00000211459	\N	Methods\n\nThe allele frequency table was made by searching the PubMed® database (1995 to September 2019). The following criteria were used for MT-RNR1: (Mitochondrial AND (A1555G OR C1494T OR T1095C) AND frequency). In addition, reports were also identified from citations by others or review articles. Studies were considered for inclusion in the MT-RNR1 frequency table if: (1) the ethnicity of the population was clearly indicated, (2) the method by which the genes were genotyped was indicated, (3) the sample population consisted of at least 50 individuals with a few exceptions (e.g., smaller cohorts that were part of larger studies) and (4) the study represented an original publication (no reviews or meta-analyses). Homoplasmic allele frequencies reported in gnomAD (https://gnomad.broadinstitute.org/) were also included .\nCaveats to estimated allele, diplotype and phenotype frequencies:\n\nSampling. Allele frequencies collected by CPIC for the supplemental tables are based on published literature reports which typically study small groups of people based on a geographic location (e.g. Malaysia, Berlin, Cairo). Almost no studies use genetic markers to estimate ancestry. Manuscripts are often focused on a specific phenotype (e.g. disease) or study only individuals taking a particular drug. Such samples would not be considered a random sample of the general population. Another consideration is that sample size is important, and PGx studies are typically not large. The frequencies collected from these studies are then used to estimate general estimates of entire ethnic population allele frequencies. Therefore, frequencies from larger groups of subjects and frequencies averaged from many sample populations probably result in better estimates.\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details, including the definitions of each group, can be found at https://www.pharmgkb.org/page/biogeographicalGroups. We strongly recommend that users use either the publication or the PharmGKB link provided to familiarize themselves with the grouping system before using these allele frequencies. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.	PHENOTYPE	387	\N	https://cpicpgx.org/gene/mt-rnr1/	\N	Common name	f	f
ABCB1	chr7	NG_011513	NP_000918	\N	\N	HGNC:40	5243	ENSG00000085563	\N	\N	PHENOTYPE	109	\N	\N	\N	\N	t	t
CYP4F2	chr19	NG_007971.2	NP_001073.3	NC_000019.10	NM_000069.2	HGNC:2645	8529	ENSG00000186115	\N	Methods\n\nThe allele frequency table was made by searching the PubMed® database (1995 to 2016). Allele frequencies reported in and gnomD browser and phase 3 1000 Genomes were also included (https://gnomad.broadinstitute.org/, http://browser.1000genomes.org/index.html) for alleles that contain single unique variant.\n\nCaveats to estimated allele, diplotype and phenotype frequencies:\n\nSampling. Allele frequencies collected by CPIC for the supplemental tables are based on published literature reports which typically study small groups of people based on a geographic location (e.g. Malaysia, Berlin, Cairo). Almost no studies use genetic markers to estimate ancestry. Manuscripts are often focused on a specific phenotype (e.g. disease) or study only individuals taking a particular drug. Such samples would not be considered a random sample of the general population. Another consideration is that sample size is important, and PGx studies are typically not large. The frequencies collected from these studies are then used to estimate general estimates of entire ethnic population allele frequencies. Therefore, frequencies from larger groups of subjects and frequencies averaged from many sample populations probably result in better estimates.\n\nEstimation of *1 frequency. In general, there are no population studies that test for all known variant alleles. Because *1 is not genotyped directly in many studies, all alleles that are negative for a sequence variation are defaulted to a *1 assignment. Because CYP4F2*1 is not genotyped directly, all alleles that are negative for a sequence variation are defaulted to a CYP4F2*1 assignment. Likewise, sequence variations of alleles that are not tested may default to a CYP4F2*1 assignment and hence contribute to the frequencies reported for this allele. Therefore, the inferred frequency for CYP4F2*1 was calculated as an average from studies describing allele frequencies for the most common alleles found in a particular biogeographical group.\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details can be found at https://www.pharmgkb.org/page/biogeographicalGroups. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.	PHENOTYPE	336	CYP4F2 diplotype to phenotype translation is not applicable to the warfarin guideline.	https://cpicpgx.org/gene/cyp4f2/	\N	Legacy Name/Class	f	f
BCHE	chr3	NG_009031	NP_000046	\N	\N	HGNC:983	590	ENSG00000114200	\N	\N	PHENOTYPE	109	\N	\N	\N	\N	t	t
TYMS	chr18	\N	NP_001062	\N	\N	HGNC:12441	7298	ENSG00000176890	\N	\N	PHENOTYPE	110	\N	\N	\N	\N	t	t
ABCG2	chr4	NG_032067.2	NP_001335914.1	NC_000004.12	NM_004827.3	HGNC:74	9429	ENSG00000118777	\N	Methods\n\nThe allele frequency table was made by searching the Genome Aggregation Database (gnomAD) and 1000 Genomes phase 3 data by rsID. In addition, pubmed were also searched to include frequencies for certain biogeographical groups (eg. Oceanian and American).\n\nCaveats to estimated allele, frequencies:\n\nSampling. Allele frequencies collected by CPIC for the supplemental tables are based on published literature reports which typically study small groups of people based on a geographic location (e.g. Malaysia, Berlin, Cairo). Almost no studies use genetic markers to estimate ancestry. Manuscripts are often focused on a specific phenotype (e.g. disease) or study only individuals taking a particular drug. Such samples would not be considered a random sample of the general population. Another consideration is that sample size is important, and PGx studies are typically not large. The frequencies collected from these studies are then used to estimate general estimates of entire ethnic population allele frequencies. Therefore, frequencies from larger groups of subjects and frequencies averaged from many sample populations probably result in better estimates.\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details, including the definitions of each group, can be found at https://www.pharmgkb.org/page/biogeographicalGroups. We strongly recommend that users use either the publication or the PharmGKB link provided to familiarize themselves with the grouping system before using these allele frequencies. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.	PHENOTYPE	330	\N	https://cpicpgx.org/gene/abcg2/	\N	\N	t	t
ACYP2	\N	\N	\N	\N	\N	HGNC:180	98	ENSG00000170634	\N	\N	PHENOTYPE	83	\N	\N	\N	\N	t	t
UMPS	chr3	NG_017037	NP_000364	\N	\N	HGNC:12563	7372	ENSG00000114491	\N	\N	PHENOTYPE	109	\N	\N	\N	\N	t	t
CFTR	chr7	NG_016465.4	NP_000483.3	NC_000007.14	NM_000069.2	HGNC:1884	1080	ENSG00000001626	\N	\N	PHENOTYPE	323	\N	https://cpicpgx.org/gene/cftr/	\N	Legacy Name/Class	t	t
UGT1A1	chr2	NG_002601.2	NP_000454.1	NC_000002.12	NM_000540.2	HGNC:12530	54658	ENSG00000241635	\N	Methods\n\nThe allele frequency table was made by searching the PubMed® database (1995 to 2015). Allele frequencies reported in phase 3 1000 Genomes were also included (http://browser.1000genomes.org/index.html).\n\nCaveats to estimated allele, diplotype and phenotype frequencies:\n\nSampling. Allele frequencies collected by CPIC for the supplemental tables are based on published literature reports which typically study small groups of people based on a geographic location (e.g. Malaysia, Berlin, Cairo). Almost no studies use genetic markers to estimate ancestry. Manuscripts are often focused on a specific phenotype (e.g. disease) or study only individuals taking a particular drug. Such samples would not be considered a random sample of the general population. Another consideration is that sample size is important, and PGx studies are typically not large. The frequencies collected from these studies are then used to estimate general estimates of entire ethnic population allele frequencies. Therefore, frequencies from larger groups of subjects and frequencies averaged from many sample populations probably result in better estimates.\n\nEstimation of *1 frequency. In general, there are no population studies that test for all known variant alleles. Because *1 is not genotyped directly in many studies, all alleles that are negative for a sequence variation are defaulted to a *1 assignment. Because UGT1A1*1 is not genotyped directly, all alleles that are negative for a sequence variation are defaulted to a UGT1A1*1 assignment. Likewise, sequence variations of alleles that are not tested may default to a UGT1A1*1 assignment and hence contribute to the frequencies reported for this allele. Therefore, the inferred frequency for UGT1A1*1 was calculated as an average from studies describing allele frequencies for the most common alleles found in a particular biogeographical group.\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details can be found at https://www.pharmgkb.org/page/biogeographicalGroups. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.	PHENOTYPE	423	\N	https://cpicpgx.org/gene/ugt1a1/	\N	Nucleotide changes from the UGT nomenclature page: https://www.pharmacogenomics.pha.ulaval.ca/wp-content/uploads/2015/04/UGT1A1-allele-nomenclature.html	f	f
CYP2C9	chr10	NG_008385.2	NP_000762.2	NC_000010.11	NM_000069.2	HGNC:2623	1559	ENSG00000138109	\N	Methods\n\nThe allele frequency table was made by searching the PubMed® database (1995 to July 2019). The following criteria were used for CYP2C9: (CYP2C9 or 2C9 or cytochrome P4502C9) AND (genotype OR allele OR frequency OR minor allele OR variant OR ethnic OR race OR racial OR ethnicity OR population) with filter limits set to retrieve "full-text" and "English" literature. In addition, reports were also identified from citations by others or review articles. Studies were considered for inclusion in the CYP2C9 frequency table if: (1) the ethnicity of the population was clearly indicated, (2) either allele frequencies or genotype frequencies were reported, (3) the method by which the genes were genotyped was indicated, (4) the sample population consisted of at least 50 individuals with a few exceptions (e.g., smaller cohorts that were part of larger studies) and (5) the study represented an original publication (no reviews or meta-analyses). Allele frequencies reported in and gnomD browser and phase 3 1000 Genomes were also included (https://gnomad.broadinstitute.org/, http://browser.1000genomes.org/index.html) for alleles that contain single unique variant.\n\nDiplotype and Phenotype Calculations. Diplotype and phenotype frequencies were estimated using the equation describing Hardy Weinberg equilibrium based on reported allele frequencies.\n\nCaveats to estimated allele, diplotype and phenotype frequencies:\n\nSampling. Allele frequencies collected by CPIC for the supplemental tables are based on published literature reports which typically study small groups of people based on a geographic location (e.g. Malaysia, Berlin, Cairo). Almost no studies use genetic markers to estimate ancestry. Manuscripts are often focused on a specific phenotype (e.g. disease) or study only individuals taking a particular drug. Such samples would not be considered a random sample of the general population. Another consideration is that sample size is important, and PGx studies are typically not large. The frequencies collected from these studies are then used to estimate general estimates of entire ethnic population allele frequencies. Therefore, frequencies from larger groups of subjects and frequencies averaged from many sample populations probably result in better estimates.\n\nEstimation of *1 frequency. In general, there are no population studies that test for all known variant alleles. Because *1 is not genotyped directly in many studies, all alleles that are negative for a sequence variation are defaulted to a *1 assignment. Because CYP2C9*1 is not genotyped directly, all alleles that are negative for a sequence variation are defaulted to a CYP2C9*1 assignment. Likewise, sequence variations of alleles that are not tested may default to a CYP2C9*1 assignment and hence contribute to the frequencies reported for this allele. Therefore, the inferred frequency for CYP2C9*1 was calculated as an average from studies describing allele frequencies for the most common alleles found in a particular biogeographical group.\n\nDiplotype/Phenotype frequency estimates. When calculating diplotype frequencies from these allele frequencies, the margin of error is compounded based on the margin of error on each allele in the diplotype. So, the margin of error will necessarily increase for diplotype frequency estimates compared to allele frequency estimates. For allele frequencies with already large margins of error due to small and non-random sampling, the diplotype margin of error could potentially be quite large. On the other hand, for well-studied alleles, the margin of error is likely low.\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details can be found at https://www.pharmgkb.org/page/biogeographicalGroups. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.	ACTIVITY_SCORE	434	CYP2C9 diplotype to phenotype translation is not applicable to the warfarin guideline.	https://cpicpgx.org/gene/cyp2c9/	Methods:\nThe PubMed and PharmGKB databases were searched for the following keywords: (CYP2C9 OR cytochrome p450 2c9)AND [genomic identifiers (e.g. dbSNP rs number, star alleles, additional common names)] AND English [Language]. Study inclusion criteria included publications that incorporated analyses for the association between CYP2C9 genotype and drug pharmacokinetic parameters, clinical outcomes, or allele function.	Legacy Name/Class	t	t
VDR	chr12	NG_008731	NP_000367	\N	\N	HGNC:12679	7421	ENSG00000111424	\N	\N	PHENOTYPE	109	\N	\N	\N	\N	t	t
CYP2D6	chr22	NG_008376.4	NP_000097.3	NC_000022.11	NM_000069.2	HGNC:2625	1565	ENSG00000100197	\N	Methods:\n\nThe CYP2D6 allele frequency tables (CYP2D6 frequency table; link to PharmGKB) are updates of those previously published in CPIC guidelines (PMID: 25974703, 24458010). Updates to the CYP2D6 allele frequency tables were made by searching the PubMed® database (1995 to 2018). The following criteria were used for CYP2D6: (CYP2D6 or 2D6 or cytochrome P4502D6) AND (genotype OR allele OR frequency OR minor allele OR variant OR ethnic OR race OR racial OR ethnicity) with filter limits set to retrieve "full-text" and "English" literature. In addition, reports were also identified from citations by others or review articles. Studies were considered for inclusion in the CYP2D6 frequency table if: (1) the ethnicity of the population was clearly indicated, (2) either allele frequencies or genotype frequencies were reported, (3) the method by which the genes were genotyped was indicated, (4) the sample population consisted of at least 50 individuals with a few exceptions (e.g., smaller cohorts that were part of larger studies) and (5) the study represented an original publication (no reviews or meta-analyses).\nDiplotype and phenotype frequencies were estimated using the equation describing Hardy Weinberg equilibrium based on reported allele frequencies. Because the frequencies for each allele are averages from all studies for that population, allele frequencies may not add up to100%. To account for this in diplotype and phenotype frequencies calculations, *1 frequency was calculated as 1 - sum (non *1 allele frequency).\n\n\nCaveats to estimated allele, diplotype and phenotype frequencies:\n\nSampling. Allele frequencies collected by CPIC for the supplemental tables are based on published literature reports which typically study small groups of people based on a geographic location (e.g. Malaysia, Berlin, Cairo). Almost no studies use genetic markers to estimate ancestry. Manuscripts are often focused on a specific phenotype (e.g. disease) or study only individuals taking a particular drug. Such samples would not be considered a random sample of the general population. Another consideration is that sample size is important, and PGx studies are typically not large. The frequencies collected from these studies are then used to estimate general estimates of entire ethnic population allele frequencies. Therefore, frequencies from larger groups of subjects and frequencies averaged from many sample populations probably result in better estimates.\n\nEstimation of *1 frequency. In general, there are no population studies that test for all known variant alleles. Because CYP2D6*1 is not genotyped directly, all alleles that are negative for a sequence variation are defaulted to a CYP2D6*1 assignment. Likewise, sequence variations of alleles that are not tested may default to a CYP2D6*1 assignment and hence contribute to the frequencies reported for this allele. Therefore, the inferred frequency for CYP2D6*1 was calculated as an average from studies describing allele frequencies for the most common alleles found in a particular ethnic group.\n\nDiplotype/Phenotype frequency estimates. When calculating diplotype frequencies from these allele frequencies, the margin of error is compounded based on the margin of error on each allele in the diplotype. So, the margin of error will necessarily increase for diplotype frequency estimates compared to allele frequency estimates. For allele frequencies with already large margins of error due to small and non-random sampling, the diplotype margin of error could potentially be quite large. On the other hand, for well-studied alleles, the margin of error is likely low.\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details, including the definitions of each group, can be found at https://www.pharmgkb.org/page/biogeographicalGroups. We strongly recommend that users use either the publication or the PharmGKB link provided to familiarize themselves with the grouping system before using these allele frequencies. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.\n\nOverestimation of allele frequencies. CYP2D6*2 is a 'default' assignment and, unless tested and discriminated for CYP2D6*8, *11, *17, *35,*41 and other variants, will default to a CYP2D6*2 assignment. The frequencies shown here may therefore be over-estimated. CYP2D6*10 is a 'default' assignment and, unless tested and discriminated for, CYP2D6*14 and *36 and other variants, will default to a CYP2D6*10 assignment. The frequencies shown here may therefore be over-estimated. CYP2D6*17 is a 'default' assignment and, unless tested and discriminated for, CYP2D6*40 and *58 will default to a CYP2D6*17 assignment. The frequencies shown here may therefore be over-estimated. CYP2D6*41 has not consistently been determined by its defining SNP (2988G>A) across studies; some platforms still use the -1584C>G SNP to discriminate between CYP2D6*2 and *41. This may lead to an overestimation of the CYP2D6*41 frequency, especially in those of African ancestry.\n\nCNV alleles. Many studies do not specify the exact copy number of duplicated alleles found in their study population and instead report the total frequency of observed CNVs as "xN". Where possible, these frequencies have been included in the CNV column for that allele (e.g. *1xN frequencies are included in the *1x2 column, *4xN frequencies are included in the *4x2 column). Users should be aware that this will lead to an overestimation of the frequency of that exact copy number in the population.	ACTIVITY_SCORE	429	\N	https://cpicpgx.org/gene/cyp2d6/	\N	Legacy Name/Class	t	t
HLA-B	chr6	NG_002397	NP_005505	\N	\N	HGNC:4932	3106	ENSG00000234745	\N	Methods\n\nThe allele frequency table was made by searching the PubMed® database (1995 to September 2019). The following criteria were used for HLA-B: (HLA-B) AND (allele OR frequency). In addition, reports were also identified from citations by others or review articles. Studies were considered for inclusion in the HLA-B frequency table if: (1) the ethnicity of the population was clearly indicated, (2) either allele frequencies or genotype frequencies were reported, (3) the method by which the genes were genotyped was indicated, (4) the sample population consisted of at least 50 individuals with a few exceptions (e.g., smaller cohorts that were part of larger studies) and (5) the study represented an original publication (no reviews or meta-analyses). Allele frequencies reported in phase 3 1000 Genomes (http://browser.1000genomes.org/index.html) and from allelefrequencies.net (https://www.allelefrequencies.net) were also included .\nCaveats to estimated allele, diplotype and phenotype frequencies:\n\nSampling. Allele frequencies collected by CPIC for the supplemental tables are based on published literature reports which typically study small groups of people based on a geographic location (e.g. Malaysia, Berlin, Cairo). Almost no studies use genetic markers to estimate ancestry. Manuscripts are often focused on a specific phenotype (e.g. disease) or study only individuals taking a particular drug. Such samples would not be considered a random sample of the general population. Another consideration is that sample size is important, and PGx studies are typically not large. The frequencies collected from these studies are then used to estimate general estimates of entire ethnic population allele frequencies. Therefore, frequencies from larger groups of subjects and frequencies averaged from many sample populations probably result in better estimates.\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details, including the definitions of each group, can be found at https://www.pharmgkb.org/page/biogeographicalGroups. We strongly recommend that users use either the publication or the PharmGKB link provided to familiarize themselves with the grouping system before using these allele frequencies. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.	ALLELE_STATUS	215	\N	https://cpicpgx.org/gene/hla/	\N	\N	f	f
COMT	chr22	NG_011526	NP_000745	\N	\N	HGNC:2228	1312	ENSG00000093010	\N	\N	PHENOTYPE	103	\N	https://cpicpgx.org/gene/comt/	\N	\N	t	t
CYP2C8	chr10	NG_007972	NP_000761	\N	\N	HGNC:2622	1558	ENSG00000138115	\N	\N	PHENOTYPE	109	\N	\N	\N	\N	t	t
CYP3A4	chr7	NG_000004	NP_059488	\N	\N	HGNC:2637	1576	ENSG00000160868	\N	\N	PHENOTYPE	109	\N	\N	\N	\N	t	t
EPHX1	chr1	NG_009776	NP_000111	\N	\N	HGNC:3401	2052	ENSG00000143819	\N	\N	PHENOTYPE	109	\N	\N	\N	\N	t	t
GGCX	chr2	NG_011811	NP_000812	\N	\N	HGNC:4247	2677	ENSG00000115486	\N	\N	PHENOTYPE	109	\N	\N	\N	\N	t	t
GP1BA	chr17	NG_008767	NP_000164	\N	\N	HGNC:4439	2811	ENSG00000185245	\N	\N	PHENOTYPE	109	\N	\N	\N	\N	t	t
GSTP1	chr11	NG_012075	NP_000843	\N	\N	HGNC:4638	2950	ENSG00000084207	\N	\N	PHENOTYPE	109	\N	\N	\N	\N	t	t
HTR2A	chr13	NG_013011	NP_000612	\N	\N	HGNC:5293	3356	ENSG00000102468	\N	\N	PHENOTYPE	109	\N	\N	\N	\N	t	t
MTHFR	chr1	NG_013351	NP_005948	\N	\N	HGNC:7436	4524	ENSG00000177000	\N	\N	PHENOTYPE	109	\N	\N	\N	\N	t	t
NQO1	chr16	NG_011504	NP_000894	\N	\N	HGNC:2874	1728	ENSG00000181019	\N	\N	PHENOTYPE	109	\N	\N	\N	\N	t	t
PROC	chr2	NG_016323	NP_000303	\N	\N	HGNC:9451	5624	ENSG00000115718	\N	\N	PHENOTYPE	109	\N	\N	\N	\N	t	t
PROS1	chr3	NG_009813	NP_000304	\N	\N	HGNC:9456	5627	ENSG00000184500	\N	\N	PHENOTYPE	109	\N	\N	\N	\N	t	t
SCN1A	chr2	NG_011906	NP_008851	\N	\N	HGNC:10585	6323	ENSG00000144285	\N	\N	PHENOTYPE	109	\N	\N	\N	\N	t	t
SLC6A4	chr17	NG_011747	NP_001036	\N	\N	HGNC:11050	6532	ENSG00000108576	\N	\N	PHENOTYPE	109	\N	\N	\N	\N	t	t
CYP3A5	chr7	NG_007938.2	NP_000768.1	NC_000007.14	NM_000069.2	HGNC:2638	1577	ENSG00000106258	\N	Methods\n\nThe allele frequency table was made by searching the PubMed® database (1995 to 2014).\n\nDiplotype and Phenotype Calculations. Diplotype and phenotype frequencies were estimated using the equation describing Hardy Weinberg equilibrium based on reported allele frequencies.\n\nCaveats to estimated allele frequencies:\n\nSampling. Allele frequencies collected by CPIC for the supplemental tables are based on published literature reports which typically study small groups of people based on a geographic location (e.g. Malaysia, Berlin, Cairo). Almost no studies use genetic markers to estimate ancestry. Manuscripts are often focused on a specific phenotype (e.g. disease) or study only individuals taking a particular drug. Such samples would not be considered a random sample of the general population. Another consideration is that sample size is important, and PGx studies are typically not large. The frequencies collected from these studies are then used to estimate general estimates of entire ethnic population allele frequencies. Therefore, frequencies from larger groups of subjects and frequencies averaged from many sample populations probably result in better estimates.\n\nEstimation of *1 frequency. In general, there are no population studies that test for all known variant alleles. Because *1 is not genotyped directly in many studies, all alleles that are negative for a sequence variation are defaulted to a *1 assignment. Because CYP3A5*1 is not genotyped directly, all alleles that are negative for a sequence variation are defaulted to a CYP3A5*1 assignment. Likewise, sequence variations of alleles that are not tested may default to a CYP3A5*1 assignment and hence contribute to the frequencies reported for this allele. Therefore, the inferred frequency for CYP3A5*1 was calculated as an average from studies describing allele frequencies for the most common alleles found in a particular biogeographical group.\n\nDiplotype/Phenotype frequency estimates. Diplotype and phenotype frequencies were estimated using the equation describing Hardy Weinberg equilibrium based on reported allele frequencies. When calculating diplotype frequencies from these allele frequencies, the margin of error is compounded based on the margin of error on each allele in the diplotype. So, the margin of error will necessarily increase for diplotype frequency estimates compared to allele frequency estimates. For allele frequencies with already large margins of error due to small and non-random sampling, the diplotype margin of error could potentially be quite large. On the other hand, for well-studied alleles, the margin of error is likely low.\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details, including the definitions of each group, can be found at https://www.pharmgkb.org/page/biogeographicalGroups. We strongly recommend that users use either the publication or the PharmGKB link provided to familiarize themselves with the grouping system before using these allele frequencies. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.\n	PHENOTYPE	428	\N	https://cpicpgx.org/gene/cyp3a5/	\N	Legacy Name/Class	t	t
SLCO1B1	chr12	NG_011745.1	NP_006437.3	NC_000012.12	NM_000540.2	HGNC:10959	10599	ENSG00000134538	\N	Methods\n\nThe allele frequency table was made by searching the PubMed® database (1995 to 2021).\n\nCaveats to estimated allele frequencies:\n\nSampling. Allele frequencies collected by CPIC for the supplemental tables are based on published literature reports which typically study small groups of people based on a geographic location (e.g. Malaysia, Berlin, Cairo). Almost no studies use genetic markers to estimate ancestry. Manuscripts are often focused on a specific phenotype (e.g. disease) or study only individuals taking a particular drug. Such samples would not be considered a random sample of the general population. Another consideration is that sample size is important, and PGx studies are typically not large. The frequencies collected from these studies are then used to estimate general estimates of entire ethnic population allele frequencies. Therefore, frequencies from larger groups of subjects and frequencies averaged from many sample populations probably result in better estimates.\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details can be found at https://www.pharmgkb.org/page/biogeographicalGroups. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.	PHENOTYPE	421	\N	https://cpicpgx.org/gene/slco1b1/	\N	Common name	t	t
CYP2C19	chr10	NG_008384.3	NP_000760.1	NC_000010.11	NM_000069.2	HGNC:2621	1557	ENSG00000165841	\N	Methods:\nThe CYP2C19 frequency table includes updates of those previously published in CPIC guidelines. Updates to the CYP2C19 frequency tables were made by searching the PubMed® database (1995 to 2015). The following criteria were used for CYP2C19: (CYP2C19 or 2C19 or cytochrome P4502C19) AND (genotype OR allele OR frequency OR minor allele OR variant OR ethnic OR race OR racial OR ethnicity) with filter limits set to retrieve "full-text" and "English" literature. In addition, reports were also identified from citations by others or review articles. Studies were considered for inclusion in the CYP2C19 frequency table if: (1) the ethnicity of the population was clearly indicated, (2) either allele frequencies or genotype frequencies were reported, (3) the method by which the genes were genotyped was indicated, (4) the sample population consisted of at least 50 individuals with a few exceptions (e.g., smaller cohorts that were part of larger studies) and (5) the study represented an original publication (no reviews or meta-analyses). Diplotype and phenotype frequencies were estimated using the equation describing Hardy Weinberg equilibrium based on reported allele frequencies.\n\nDiplotype and Phenotype Calculations. Diplotype and phenotype frequencies were estimated using the equation describing Hardy Weinberg equilibrium based on reported allele frequencies.\n\nCaveats to estimated allele, diplotype and phenotype frequencies:\n\nSampling. Allele frequencies collected by CPIC for the supplemental tables are based on published literature reports which typically study small groups of people based on a geographic location (e.g. Malaysia, Berlin, Cairo). Almost no studies use genetic markers to estimate ancestry. Manuscripts are often focused on a specific phenotype (e.g. disease) or study only individuals taking a particular drug. Such samples would not be considered a random sample of the general population. Another consideration is that sample size is important, and PGx studies are typically not large. The frequencies collected from these studies are then used to estimate general estimates of entire ethnic population allele frequencies. Therefore, frequencies from larger groups of subjects and frequencies averaged from many sample populations probably result in better estimates.\n\nEstimation of *1 frequency. In general, there are no population studies that test for all known variant alleles. Because *1 is not genotyped directly in many studies, all alleles that are negative for a sequence variation are defaulted to a *1 assignment. The inferred frequency for *1 is estimated as: 100 - (sum of averaged variant allele frequencies). For genes where many alleles are not tested for in any population, and frequency of 'common' alleles is not well documented in many understudied populations (Oceanian, Central/South Asian, Latino), the *1 frequency will deviate even more from true values.\n\nDiplotype/Phenotype frequency estimates. Diplotype and phenotype frequencies were estimated using the equation describing Hardy Weinberg equilibrium based on reported allele frequencies. When calculating diplotype frequencies from these allele frequencies, the margin of error is compounded based on the margin of error on each allele in the diplotype. So, the margin of error will necessarily increase for diplotype frequency estimates compared to allele frequency estimates. For allele frequencies with already large margins of error due to small and non-random sampling, the diplotype margin of error could potentially be quite large. On the other hand, for well-studied alleles, the margin of error is likely low.\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details, including the definitions of each group, can be found at https://www.pharmgkb.org/page/biogeographicalGroups. We strongly recommend that users use either the publication or the PharmGKB link provided to familiarize themselves with the grouping system before using these allele frequencies. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.	PHENOTYPE	432	\N	https://cpicpgx.org/gene/cyp2c19/	\N	Legacy Name/Class	t	t
IFNL3	chr19	NG_042193.1	NP_000101.2	NC_000019.10	NM_001042351.2	HGNC:18365	282617	ENSG00000197110	\N	\N	ALLELE_STATUS	226	\N	https://cpicpgx.org/gene/ifnl/	\N	Common Name	t	t
G6PD	chrX	NG_009015.2	NP_000101.2	NC_000023.11	NM_001042351.2	HGNC:4057	2539	ENSG00000160211	\N	Methods\n\nThe allele frequency table was made by searching the gnomAD database.\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details can be found at https://www.pharmgkb.org/page/biogeographicalGroups. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n	PHENOTYPE	377	\N	https://cpicpgx.org/gene/g6pd/	\N	Legacy Name/Class	f	f
TPMT	chr6	NG_012137.2	NP_000358.1	NC_000006.12	NM_000540.2	HGNC:12014	7172	ENSG00000137364	\N	The allele frequency table was made by searching the PubMed® database (no start date to 1/2018). Allele frequencies reported in the gnomAD browser (http://gnomad.broadinstitute.org/ - exomes and genomes) and ensembl (grch37.ensembl.org - exomes or genomes) were also included. URLs are included in the "PMID" column.\n\nDiplotype and Phenotype Calculations. Diplotype and phenotype frequencies were estimated using the equation describing Hardy Weinberg equilibrium based on reported allele frequencies.\n\nCaveats to estimated allele, diplotype and phenotype frequencies:\n\nSampling. Allele frequencies collected by CPIC for the supplemental tables are based on published literature reports which typically study small groups of people based on a geographic location (e.g. Malaysia, Berlin, Cairo). Almost no studies use genetic markers to estimate ancestry. Manuscripts are often focused on a specific phenotype (e.g. disease) or study only individuals taking a particular drug. Such samples would not be considered a random sample of the general population. Another consideration is that sample size is important, and PGx studies are typically not large. The frequencies collected from these studies are then used to estimate general estimates of entire ethnic population allele frequencies. Therefore, frequencies from larger groups of subjects and frequencies averaged from many sample populations probably result in better estimates.\n\nEstimation of *1 frequency. In general, there are no population studies that test for all known variant alleles. Because *1 is not genotyped directly in many studies, all alleles that are negative for a sequence variation are defaulted to a *1 assignment. The inferred frequency for *1 is estimated as: 100 - (sum of averaged variant allele frequencies). For genes where many alleles are not tested for in any population, and frequency of 'common' alleles is not well documented in many understudied populations (Oceania, South Asian, Latino), the *1 frequency will deviate even more from true values.\n\nDiplotype/Phenotype frequency estimates. Diplotype and phenotype frequencies were estimated using the equation describing Hardy Weinberg equilibrium based on reported allele frequencies. When calculating diplotype frequencies from these allele frequencies, the margin of error is compounded based on the margin of error on each allele in the diplotype. So, the margin of error will necessarily increase for diplotype frequency estimates compared to allele frequency estimates. For allele frequencies with already large margins of error due to small and non-random sampling, the diplotype margin of error could potentially be quite large. On the other hand, for well-studied alleles, the margin of error is likely low.\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details can be found at https://www.pharmgkb.org/page/biogeographicalGroups. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.	PHENOTYPE	421	\N	https://cpicpgx.org/gene/tpmt/	\N	Nucleotide change on cDNA from https://liu.se/en/research/tpmt-nomenclature-committee	t	t
CYP2B6	chr19	NG_007929.1	NP_000758.1	NC_000019.10	NM_000069.2	HGNC:2615	1555	ENSG00000197408	\N	Methods\n\nThe allele frequency table was made by searching the PubMed® database (no start date to May 2018). Studies were considered for inclusion in the CYP2B6 Frequency Table if (1) the ethnicity of the population was clearly indicated; (2) either allele frequencies or genotype frequencies were reported; and (3) the method by which genes were genotyped was indicated. Allele frequencies reported in the gnomAD browser (http://gnomad.broadinstitute.org/ - exomes and genomes) and 1000 Genomes Project phase 3 data on Ensemble browser (https://uswest.ensembl.org/index.html) were also included.\n\nDiplotype and Phenotype Calculations. Diplotype and phenotype frequencies were estimated using the equation describing Hardy Weinberg equilibrium based on reported allele frequencies.\n\nCaveats to estimated allele, diplotype and phenotype frequencies:\n\nSampling. Allele frequencies collected by CPIC for the supplemental tables are based on published literature reports which typically study small groups of people based on a geographic location (e.g. Malaysia, Berlin, Cairo). Almost no studies use genetic markers to estimate ancestry. Manuscripts are often focused on a specific phenotype (e.g. disease) or study only individuals taking a particular drug. Such samples would not be considered a random sample of the general population. Another consideration is that sample size is important, and PGx studies are typically not large. Studies were included in the frequency calculation regardless of number. The frequencies collected from these studies are then used to estimate general estimates of entire ethnic population allele frequencies. Therefore, frequencies from larger groups of subjects and frequencies averaged from many sample populations probably result in better estimates.\n\nEstimation of *1 frequency. In general, there are no population studies that test for all known variant alleles. Because *1 is not genotyped directly in many studies, all alleles that are negative for a sequence variation are defaulted to a *1 assignment. The inferred frequency for *1 is estimated as: 1 - (sum of averaged variant allele frequencies). For genes where many alleles are not tested for in any population, and frequency of 'common' alleles is not well documented in many understudied populations (Oceania, Middle eastern, South Asian, Latino), the *1 frequency will deviate even more from true values.\n\nDiplotype/Phenotype frequency estimates. Diplotype and phenotype frequencies were estimated using the equation describing Hardy Weinberg equilibrium based on reported allele frequencies. When calculating diplotype frequencies from these allele frequencies, the margin of error is compounded based on the margin of error on each allele in the diplotype. So, the margin of error will necessarily increase for diplotype frequency estimates compared to allele frequency estimates. For allele frequencies with already large margins of error due to small and non-random sampling, the diplotype margin of error could potentially be quite large. On the other hand, for well-studied alleles, the margin of error is likely low.\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details, including the definitions of each group, can be found at https://www.pharmgkb.org/page/biogeographicalGroups. We strongly recommend that users use either the publication or the PharmGKB link provided to familiarize themselves with the grouping system before using these allele frequencies. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.	PHENOTYPE	433	\N	https://cpicpgx.org/gene/cyp2b6/	\N	Legacy Name/Class	t	t
CACNA1S	chr1	NG_009816.1	NP_000060.2	NC_000001.11	NM_000069.2	HGNC:1397	779	ENSG00000081248	\N	Methods\n\nThe allele frequency table was made by searching the Genome Aggregation Database (gnomAD) by each rsID\n\nCaveats to estimated allele, frequencies:\n\nSampling. Allele frequencies collected by CPIC for the supplemental tables are based on published literature reports which typically study small groups of people based on a geographic location (e.g. Malaysia, Berlin, Cairo). Almost no studies use genetic markers to estimate ancestry. Manuscripts are often focused on a specific phenotype (e.g. disease) or study only individuals taking a particular drug. Such samples would not be considered a random sample of the general population. Another consideration is that sample size is important, and PGx studies are typically not large. The frequencies collected from these studies are then used to estimate general estimates of entire ethnic population allele frequencies. Therefore, frequencies from larger groups of subjects and frequencies averaged from many sample populations probably result in better estimates.\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details, including the definitions of each group, can be found at https://www.pharmgkb.org/page/biogeographicalGroups. We strongly recommend that users use either the publication or the PharmGKB link provided to familiarize themselves with the grouping system before using these allele frequencies. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.	PHENOTYPE	434	\N	https://cpicpgx.org/gene/cacna1s/	\N	\N	f	f
VKORC1	chr16	NG_011564.1	NP_076869.1	NC_000016.10	NM_000540.2	HGNC:23663	79001	ENSG00000167397	\N	Methods\n\nThe allele frequency table was made by searching the PubMed® database (1995 to 2016). Allele frequencies reported in phase 3 1000 Genomes were also included (http://browser.1000genomes.org/index.html).\n\nCaveats to estimated allele, diplotype and phenotype frequencies:\n\nSampling. Allele frequencies collected by CPIC for the supplemental tables are based on published literature reports which typically study small groups of people based on a geographic location (e.g. Malaysia, Berlin, Cairo). Almost no studies use genetic markers to estimate ancestry. Manuscripts are often focused on a specific phenotype (e.g. disease) or study only individuals taking a particular drug. Such samples would not be considered a random sample of the general population. Another consideration is that sample size is important, and PGx studies are typically not large. The frequencies collected from these studies are then used to estimate general estimates of entire ethnic population allele frequencies. Therefore, frequencies from larger groups of subjects and frequencies averaged from many sample populations probably result in better estimates.\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details can be found at https://www.pharmgkb.org/page/biogeographicalGroups. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.	PHENOTYPE	331	VKORC1 diplotype to phenotype translation is not applicable to the warfarin guideline.	https://cpicpgx.org/gene/vkorc1/	\N	Common Name	f	f
\.


--
-- Data for Name: gene_result; Type: TABLE DATA; Schema: cpic; Owner: -
--

COPY cpic.gene_result (id, genesymbol, result, activityscore, ehrpriority, consultationtext, version, frequency) FROM stdin;
7731593	CYP2B6	Normal Metabolizer	n/a	Normal/Routine/Low Risk	This result signifies that the patient has two copies of normal function alleles. Based on the genotype result this patient is predicted to be an normal metabolizer of CYP2B6 substrates. There is no reason to selectively adjust the dose of most medications that are metabolized by CYP2B6. Please consult a clinical pharmacist for more information about how CYP2B6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.33582056, "European": 0.42950228, "Oceanian": 0.12960002, "East Asian": 0.48562673, "Near Eastern": 0.29052103, "Central/South Asian": 0.42183065, "Sub-Saharan African": 0.14307445, "African American/Afro-Caribbean": 0.333572}
7834697	SLCO1B1	Indeterminate	n/a	none	This result signifies that the patient has an allele combination with unknown or uncertain function alleles. The expected phenotype for this patient cannot be determined currently based on the SLCO1B1 diplotype result. Please consult a clinical pharmacist for more specific information about how SLCO1B1 function influences drug dosing.	3	{"American": 0.0, "European": 0.001279436, "Oceanian": 0.0, "East Asian": 0.007855513, "Near Eastern": 0.0, "Central/South Asian": 0.0005580649, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": 0.0}
7834667	SLCO1B1	Decreased Function	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a normal function allele (*_) and one copy of a no function allele (*_). Based on the genotype result, this patient is predicted to have decreased SLCO1B1 function. This patient may be at risk for an adverse response to medications that are affected by SLCO1B1. To avoid an untoward drug response, dose adjustments may be necessary for medications affected by SLCO1B1 (i.e. statins). Please consult a clinical pharmacist for more specific information about how SLCO1B1 function influences drug dosing.	3	{"American": 0.3648, "European": 0.28296122, "Oceanian": 0.0, "East Asian": 0.21842287, "Near Eastern": 0.32000002, "Central/South Asian": 0.12971397, "Sub-Saharan African": 0.054308295, "African American/Afro-Caribbean": 0.0198}
7834746	SLCO1B1	Poor Function	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has two copies of a no function allele. Based on the genotype result, this patient is predicted to have low SLCO1B1 function. This patient may be at a high risk for an adverse response to medications that are affected by SLCO1B1 (i.e. statins). To avoid an untoward drug response, dose adjustments or alternative therapeutic agents may be necessary for medications affected by SLCO1B1. Please consult a clinical pharmacist for more specific information about how SLCO1B1 function influences drug dosing.	3	{"American": 0.0576, "European": 0.02916489, "Oceanian": 0.0, "East Asian": 0.015759302, "Near Eastern": 0.040000003, "Central/South Asian": 0.004863923, "Sub-Saharan African": 0.0007803353, "African American/Afro-Caribbean": 0.00010}
7834662	SLCO1B1	Increased Function	n/a	Normal/Routine/Low Risk	This result signifies that the patient has two copies of an increased function allele. Based on the genotype result, this patient is predicted to have increased SLCO1B1 function. This means that there is no reason to adjust the dose of most medications that are affected by SLCO1B1 on the basis of SLCO1B1 genetic status at this time. Please consult a clinical pharmacist for more specific information about how SLCO1B1 function influences drug dosing.	3	{"American": 0.0, "European": 0.029916462, "Oceanian": 0.0, "East Asian": 0.0, "Near Eastern": 0.0, "Central/South Asian": 0.0, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": 0.0}
7731775	CYP2B6	Poor Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has two copies of a no function allele OR two copies of a decreased function allele OR one copy of a no function allele and one copy of a decreased function allele. Based on the genotype result this patient is predicted to be a poor metabolizer of CYP2B6 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2B6. To avoid an untoward drug response, dose adjustments or or alternative therapy may be necessary for medications metabolized by CYP2B6. Please consult a clinical pharmacist for more information about how CYP2B6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.09452413, "European": 0.07428478, "Oceanian": 0.4096, "East Asian": 0.0436291, "Near Eastern": 0.127449, "Central/South Asian": 0.059536003, "Sub-Saharan African": 0.23673655, "African American/Afro-Caribbean": 0.15714757}
7732032	CYP2B6	Indeterminate	n/a	none	This result signifies that the patient has an allele combination with uncertain and/or unknown function alleles. The expected phenotype for this patient cannot be determined currently based on the CYP2B6 diplotype result. Please consult a clinical pharmacist for more specific information about how CYP2B6 function influences drug dosing.	3	{"Latino": 0.013596146, "European": 0.06145065, "Oceanian": 0.0, "East Asian": 0.020025712, "Near Eastern": 0.0, "Central/South Asian": 0.014973663, "Sub-Saharan African": 0.25210795, "African American/Afro-Caribbean": 0.031204166}
7731582	CYP2B6	Ultrarapid Metabolizer	n/a	Normal/Routine/Low Risk	This result signifies that the patient has two copies of increased function alleles. Based on the genotype result this patient is predicted to be an ultrarapid metabolizer of CYP2B6 substrates. There is no reason to selectively adjust the dose of most medications that are metabolized by CYP2B6. Please consult a clinical pharmacist for more information about how CYP2B6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.011284955, "European": 0.0016704409, "Oceanian": 0.0, "East Asian": 0.007088209, "Near Eastern": 0.010816, "Central/South Asian": 0.009801, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": 0.000106068765}
7732782	CYP2C19	Rapid Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a normal function allele and one copy of an increased function allele. Based on the genotype result this patient is predicted to be a rapid metabolizer of CYP2C19 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2C19. To avoid an untoward drug response, dose adjustments or alternative therapeutic agents may be necessary for medications metabolized by CYP2C19. Please consult a clinical pharmacist for more information about how CYP2C19 metabolic status influences drug selection and dosing.	3	{"Latino": 0.24136075, "American": 0.13638271, "European": 0.2711846, "Oceanian": 0.021329276, "East Asian": 0.025343522, "Near Eastern": 0.2573682, "Central/South Asian": 0.18567303, "Sub-Saharan African": 0.21080859, "African American/Afro-Caribbean": 0.2373838}
7733147	CYP2C19	Indeterminate	n/a	none	This result signifies that the patient has an allele combination with uncertain and/or unknown function alleles. The expected phenotype for this patient cannot be determined currently based on the CYP2C19 diplotype result. Please consult a clinical pharmacist for more specific information about how CYP2C19 function influences drug dosing.	3	{"Latino": 0.0, "American": 0.0, "European": 0.0, "Oceanian": 0.0, "East Asian": 0.0034064606, "Near Eastern": 0.0, "Central/South Asian": 0.0, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": 0.0022393465}
7732894	CYP2C19	Intermediate Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a normal function allele and one copy of a no function allele OR one copy of an increased function and one copy of a no function allele. Based on the genotype result this patient is predicted to be an intermediate metabolizer of CYP2C19 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2C19. To avoid an untoward drug response, dose adjustments or alternative therapeutic agents may be necessary for medications metabolized by CYP2C19. Please consult a clinical pharmacist for more information about how CYP2C19 metabolic status influences drug selection and dosing.	3	{"Latino": 0.19035932, "American": 0.21383229, "European": 0.26108757, "Oceanian": 0.36902928, "East Asian": 0.45928204, "Near Eastern": 0.2354828, "Central/South Asian": 0.40806636, "Sub-Saharan African": 0.29945874, "African American/Afro-Caribbean": 0.31398684}
7835855	TPMT	Poor Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has two copies of a no function allele. Based on the genotype result this patient is predicted to be a TPMT poor metabolizer. This patient may be at a high risk for an adverse reactions to medications that are metabolized by TPMT (eg. thiopurines). To avoid an untoward drug response, dose adjustments or or alternative therapy may be necessary for medications metabolized by TPMT. However, thiopurines can be affected by a patient's TPMT and NUDT15 phenotype. Please consult a clinical pharmacist for more information about how TPMT and NUDT16 metabolic status influences drug selection and dosing.	3	{"Latino": 0.0028794738, "European": 0.0020956735, "East Asian": 0.00041297937, "Near Eastern": 0.0011826118, "Central/South Asian": 0.0003435882, "Sub-Saharan African": 0.002971174, "African American/Afro-Caribbean": 0.0013917874}
7732993	CYP2C19	Likely Poor Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a decreased function allele and one copy of a no function allele. Based on the genotype result this patient MAY be a poor metabolizer of CYP2C19 substrates. This patient may be at a high risk for an adverse or poor response to medications that are metabolized by CYP2C19. To avoid an untoward drug response, dose adjustments or or alternative therapy may be necessary for medications metabolized by the CYP2C19. Please consult a clinical pharmacist for more information about how CYP2C19 metabolic status influences drug selection and dosing.	3	{"Latino": 0.0004440685, "American": 0.0, "European": 0.00020405183, "Oceanian": 0.0, "East Asian": 0.0004349198, "Near Eastern": 0.0, "Central/South Asian": 0.0, "Sub-Saharan African": 0.010332189, "African American/Afro-Caribbean": 0.007090685}
7732791	CYP2C19	Normal Metabolizer	n/a	Normal/Routine/Low Risk	This result signifies that the patient has two copies of a normal function allele. Based on the genotype result this patient is predicted to be an normal metabolizer of CYP2C19 substrates. There is no reason to selectively adjust the dose of most medications that are metabolized by CYP2C19. Please consult a clinical pharmacist for more information about how CYP2C19 metabolic status influences drug selection and dosing.	3	{"Latino": 0.5249766, "American": 0.62755567, "European": 0.39611652, "Oceanian": 0.035006005, "East Asian": 0.38055435, "Near Eastern": 0.45192146, "Central/South Asian": 0.29552925, "Sub-Saharan African": 0.36977687, "African American/Afro-Caribbean": 0.32805592}
7835424	TPMT	Normal Metabolizer	n/a	Normal/Routine/Low Risk	This result signifies that the patient has two copies of a normal function allele OR one copy of a normal function allele and one copy of a decreased function allele. Based on the genotype result this patient is predicted to be a TPMT normal metabolizer. There is no reason to selectively adjust the dose of most medications that are metabolized by TPMT. However, thiopurines can be affected by a patient's TPMT and NUDT15 phenotype. Please consult a clinical pharmacist for more information about how TPMT and NUDT15 metabolic status influences drug selection and dosing.	3	{"Latino": 0.8923553, "European": 0.90923065, "East Asian": 0.9596651, "Near Eastern": 0.93240434, "Central/South Asian": 0.96327126, "Sub-Saharan African": 0.8933782, "African American/Afro-Caribbean": 0.8646596}
7733468	CYP2C9	Normal Metabolizer	2.0	Normal/Routine/Low Risk	This result signifies that the patient has two copies of a normal function allele. Based on the genotype result, this patient is predicted to be a CYP2C9 Normal metabolizer. Based only on the CYP2C9 genotype, there is no reason to adjust the dose of most medications that are affected by CYP2C9. Please consult a clinical pharmacist for more specific information about how CYP2C9 function influences drug dosing.	3	{"Latino": 0.74342215, "American": 0.83149743, "European": 0.62845254, "Oceanian": 0.9122409, "East Asian": 0.8378542, "Near Eastern": 0.61125296, "Central/South Asian": 0.5961676, "Sub-Saharan African": 0.73114437, "African American/Afro-Caribbean": 0.75866354}
7733517	CYP2C9	Intermediate Metabolizer	1.0	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a normal function allele and one copy of a no function allele OR two copies of decreased function alleles. Based on the genotype result, this patient is predicted to be a CYP2C9 intermediate metabolizer (activity score of 1). This patient may be at risk for an adverse response to medications that are affected by CYP2C9. Please consult a clinical pharmacist for more specific information about how CYP2C9 intermediate metabolizer status influences drug dosing.	3	{"Latino": 0.08109343, "American": 0.05818467, "European": 0.13767911, "Oceanian": 0.03061276, "East Asian": 0.098925985, "Near Eastern": 0.1494271, "Central/South Asian": 0.18352722, "Sub-Saharan African": 0.049747862, "African American/Afro-Caribbean": 0.049812526}
7733777	CYP2C9	Poor Metabolizer	0.5	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a decreased function allele and one copy of a no function allele. Based on the genotype result, this patient is predicted to be a CYP2C9 poor metabolizer. This patient may be at high risk for an adverse response to medications that are affected by CYP2C9. Please consult a clinical pharmacist for more specific information about how CYP2C9 intermediate metabolizer status influences drug dosing.	3	{"Latino": 0.007974847, "American": 0.0034911723, "European": 0.019907156, "Oceanian": 0.0009130932, "East Asian": 0.0030826868, "Near Eastern": 0.022547128, "Central/South Asian": 0.025517693, "Sub-Saharan African": 0.0049882242, "African American/Afro-Caribbean": 0.004712071}
7734145	CYP2C9	Indeterminate	n/a	none	This result signifies that the patient has an allele combination with uncertain and/or unknown function alleles. The expected phenotype for this patient cannot be determined currently based on the CYP2C9 diplotype result. Please consult a clinical pharmacist for more specific information about how CYP2C9 function influences drug dosing.	3	{"Latino": 0.0009997501, "American": 0.0, "European": 0.00059991, "Oceanian": 0.0, "East Asian": 0.0046076896, "Near Eastern": 0.0, "Central/South Asian": 0.0037963898, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": 0.0}
7836714	UGT1A1	Indeterminate	n/a	none	This result signifies that the patient has an allele combination with uncertain and/or unknown function alleles. The expected phenotype for this patient cannot be determined currently based on the UGT1A1 diplotype result. UGT1A1*80 is in very high linkage disequilibrium with *28 and *37. In the rare event that *80 is detected but *28 and *37 are not, there are not enough clinical data to predict metabolizer status with certainty. However, if only *80 is interrogated and the patient is heterozygous or homozygous for *80, an intermediate or poor metabolizer phenotype may be inferred, respectively. Please consult a clinical pharmacist for more specific information about how UGT1A1 function influences drug dosing.	2	\N
7836676	UGT1A1	Intermediate Metabolizer	n/a	Normal/Routine/Low Risk	This result signifies that the patient has one copy of a normal function allele (*1) OR one copy of an increased function allele (*36), AND and one copy of a decreased function allele (*_). Based on the genotype result this patient is predicted to be an intermediate metabolizer of UGT1A1 substrates. There is no reason to selectively adjust the dose of most medications that inhibit or are inactivated by UGT1A1. Please consult a clinical pharmacist for more information about how UGT1A1 metabolic status influences drug selection and dosing.	2	\N
7836669	UGT1A1	Normal Metabolizer	n/a	Normal/Routine/Low Risk	This result signifies that the patient has two copies of a normal function allele (*1) OR one copy of a normal function allele (*1) and one copy of an increased function allele (*36) OR two copies of an increased function allele (*36). Based on the genotype result this patient is predicted to be an normal metabolizer of UGT1A1 substrates. There is no reason to selectively adjust the dose of most medications that inhibit or are inactivated by UGT1A1. Please consult a clinical pharmacist for more information about how UGT1A1 metabolic status influences drug selection and dosing.	2	\N
7836691	UGT1A1	Poor Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has two copies of decreased function alleles (*_ and *_). Based on the genotype result this patient is predicted to be a poor metabolizer of UGT1A1 substrates. This patient may be at risk for an adverse or poor response to medications that inhibit or are inactivated by UGT1A1. Based on the genotype result, this patient is predicted to have low UGT1A1 function, which is generally indicative of Gilbert syndrome. This patient may be at high risk for toxicity from select medications that inhibit or are inactivated by UGT1A1. Please consult a clinical pharmacist for more information about how UGT1A1 metabolic status influences drug selection and dosing.	2	\N
7733473	CYP2C9	Intermediate Metabolizer	1.5	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a normal function allele and one copy of a decreased function allele. Based on the genotype result, this patient is predicted to be a CYP2C9 intermediate metabolizer (activity score of 1.5). This patient may be at risk for an adverse response to medications that are affected by CYP2C9. Please consult a clinical pharmacist for more specific information about how CYP2C9 intermediate metabolizer status influences drug dosing.	3	{"Latino": 0.1647683, "American": 0.10592343, "European": 0.20758142, "Oceanian": 0.05599055, "East Asian": 0.052658077, "Near Eastern": 0.2097067, "Central/South Asian": 0.17885593, "Sub-Saharan African": 0.21372117, "African American/Afro-Caribbean": 0.1863267}
7736344	CYP2D6	Ultrarapid Metabolizer	≥5.0	Abnormal/Priority/High Risk	This result signifies that this patient has [X copies of a normal function allele (*_xN)] [X copies of a decreased function allele (*_)] [X copies of a no function allele (*_)]. Based on the genotype result this patient is predicted to be an ultrarapid metabolizer of CYP2D6 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2D6. To avoid an untoward drug response, dose adjustments may be necessary for medications metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.000055729302, "American": 0.00006450697, "European": 0.000058472542, "Oceanian": 0.0, "East Asian": 0.000015887783, "Near Eastern": 0.0, "Central/South Asian": 0.0, "Sub-Saharan African": 0.00025361063, "African American/Afro-Caribbean": 0.0}
7736362	CYP2D6	Ultrarapid Metabolizer	≥4.0	Abnormal/Priority/High Risk	This result signifies that this patient has [X copies of a normal function allele (*_xN)] [X copies of a decreased function allele (*_)] [X copies of a no function allele (*_)]. Based on the genotype result this patient is predicted to be an ultrarapid metabolizer of CYP2D6 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2D6. To avoid an untoward drug response, dose adjustments may be necessary for medications metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.0012809848, "American": 0.0015109289, "European": 0.0018874556, "Oceanian": 0.0, "East Asian": 0.0007779561, "Near Eastern": 0.0, "Central/South Asian": 0.0, "Sub-Saharan African": 0.0038317435, "African American/Afro-Caribbean": 0.0}
7736396	CYP2D6	Ultrarapid Metabolizer	≥3.5	Abnormal/Priority/High Risk	This result signifies that this patient has [X copies of a normal function allele (*_xN)] [X copies of a decreased function allele (*_)] [X copies of a no function allele (*_)]. Based on the genotype result this patient is predicted to be an ultrarapid metabolizer of CYP2D6 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2D6. To avoid an untoward drug response, dose adjustments may be necessary for medications metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.00008051411, "American": 0.00001657463, "European": 0.000031193038, "Oceanian": 0.0, "East Asian": 0.00004386605, "Near Eastern": 0.0, "Central/South Asian": 0.0, "Sub-Saharan African": 0.0030223487, "African American/Afro-Caribbean": 0.0}
7736424	CYP2D6	Ultrarapid Metabolizer	≥3.25	Abnormal/Priority/High Risk	This result signifies that this patient has [X copies of a normal function allele (*_xN)] [X copies of a decreased function allele (*_)] [X copies of a no function allele (*_)]. Based on the genotype result this patient is predicted to be an ultrarapid metabolizer of CYP2D6 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2D6. To avoid an untoward drug response, dose adjustments may be necessary for medications metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.00018561553, "American": 0.00009731066, "European": 0.00046782166, "Oceanian": 0.0, "East Asian": 0.0009120896, "Near Eastern": 0.0, "Central/South Asian": 0.0, "Sub-Saharan African": 0.000952962, "African American/Afro-Caribbean": 0.0}
7736546	CYP2D6	Ultrarapid Metabolizer	4.0	Abnormal/Priority/High Risk	This result signifies that this patient has [X copies of a normal function allele (*_xN)] [X copies of a decreased function allele (*_)] [X copies of a no function allele (*_)]. Based on the genotype result this patient is predicted to be an ultrarapid metabolizer of CYP2D6 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2D6. To avoid an untoward drug response, dose adjustments may be necessary for medications metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.0007764387, "American": 0.0010402872, "European": 0.0003002313, "Oceanian": 0.014133941, "East Asian": 0.000063105406, "Near Eastern": 0.0041771694, "Central/South Asian": 0.00016144973, "Sub-Saharan African": 0.0006431835, "African American/Afro-Caribbean": 0.0007742127}
7736577	CYP2D6	Ultrarapid Metabolizer	3.0	Abnormal/Priority/High Risk	This result signifies that this patient has [X copies of a normal function allele (*_xN)] [X copies of a decreased function allele (*_)] [X copies of a no function allele (*_)]. Based on the genotype result this patient is predicted to be an ultrarapid metabolizer of CYP2D6 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2D6. To avoid an untoward drug response, dose adjustments may be necessary for medications metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.035694193, "American": 0.048732717, "European": 0.019382542, "Oceanian": 0.16405001, "East Asian": 0.006179998, "Near Eastern": 0.06435209, "Central/South Asian": 0.014773737, "Sub-Saharan African": 0.019435417, "African American/Afro-Caribbean": 0.025694855}
7753242	CYP3A5	Normal Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has two copies of a normal function allele. Patients with this genotype are expected to require higher starting tacrolimus dosing (1.5 times to 2 times the standard dose-maximum starting dose not to exceed 0.3mg/kg/day). Further dose adjustments or selection of alternative therapy may be necessary due to other clinical factors (e.g., medication interactions, or hepatic function). Please consult a clinical pharmacist for more specific dosing information.	3	{"Latino": 0.029857205, "European": 0.005491413, "East Asian": 0.064288594, "Near Eastern": 0.014869832, "Central/South Asian": 0.106746115, "Sub-Saharan African": 0.22983262, "African American/Afro-Caribbean": 0.20507748}
7753245	CYP3A5	Intermediate Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a normal function allele and one copy of a no function allele. Patients with this genotype are expected to require higher starting tacrolimus dosing (1.5 times to 2 times the standard dose-maximum starting dose not to exceed 0.3mg/kg/day). Further dose adjustments or selection of alternative therapy may be necessary due to other clinical factors (e.g., medication interactions, or hepatic function). Please consult a clinical pharmacist for more specific dosing information.	3	{"Latino": 0.28587034, "European": 0.13722531, "East Asian": 0.37852672, "Near Eastern": 0.21414419, "Central/South Asian": 0.43994826, "Sub-Saharan African": 0.499152, "African American/Afro-Caribbean": 0.4955547}
7753250	CYP3A5	Poor Metabolizer	n/a	Normal/Routine/Low Risk	This result signifies that the patient has two copies of a no function allele. Patients with this genotype are expected to require standard tacrolimus dosing. Please consult a clinical pharmacist for more specific dosing information.	3	{"Latino": 0.68427247, "European": 0.85728335, "East Asian": 0.5571847, "Near Eastern": 0.770986, "Central/South Asian": 0.45330563, "Sub-Saharan African": 0.2710154, "African American/Afro-Caribbean": 0.2993679}
7753258	CYP3A5	Possible Intermediate Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a normal function allele and one copy of an uncertain or unknown function allele. Patients with this genotype are expected to require higher starting tacrolimus dosing (1.5 times to 2 times the standard dose-maximum starting dose not to exceed 0.3mg/kg/day). Further dose adjustments or selection of alternative therapy may be necessary due to other clinical factors (e.g., medication interactions, or hepatic function). Please consult a clinical pharmacist for more specific dosing information.	3	{"Latino": 0.0, "European": 0.0, "East Asian": 0.0, "Near Eastern": 0.0, "Central/South Asian": 0.0, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": 0.0}
7753262	CYP3A5	Indeterminate	n/a	none	This result signifies that the patient has an allele combination with uncertain and/or unknown function alleles. The expected phenotype for this patient cannot be determined currently based on the CYP3A5 diplotype result. Please consult a clinical pharmacist for more specific information about how CYP3A5 function influences drug dosing.	3	{"Latino": 0.0, "European": 0.0, "East Asian": 0.0, "Near Eastern": 0.0, "Central/South Asian": 0.0, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": 0.0}
7753274	DPYD	Normal Metabolizer	2.0	Normal/Routine/Low Risk	This result signifies that the patient has two copies of normal function DPYD alleles. Based on the genotype result this patient is predicted to be DPYD Normal Metabolizer with a DPYD activity score of 2. For this genotype, no selective dose adjustment is indicated for medications that are metabolized by DPD. Please consult a clinical pharmacist for more information about how DPD metabolic status influences drug selection and dosing.	2	\N
7754872	DPYD	Intermediate Metabolizer	1.5	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a normal function allele and one copy of a decreased function allele of the DPYD gene. Based on the genotype result this patient is predicted to be a DPYD Intermediate Metabolizer with a DPYD activity score of 1.5. This patient may be at risk for adverse drug reactions to medications that are metabolized by DPD (i.e. 5-fluorouracil, capecitabine, and tegafur) and a dose adjustment may be indicated. Please consult a clinical pharmacist for more information about how DPD metabolic status influences drug selection and dosing.	2	\N
7755266	DPYD	Intermediate Metabolizer	1.0	Abnormal/Priority/High Risk	This result signifies that the patient has either one copy of a normal function allele and one copy of a no function allele of the DPYD gene OR two copies of decreased function alleles of the DPYD gene. Based on the genotype result this patient is predicted to be a DPYD Intermediate Metabolizer with a DPYD activity score of 1. This patient may be at risk for adverse drug reactions to medications that are metabolized by DPD (i.e. 5-fluorouracil, capecitabine, and tegafur) and a dose adjustment may be indicated. Please consult a clinical pharmacist for more information about how DPD metabolic status influences drug selection and dosing.	2	\N
7756473	DPYD	Poor Metabolizer	0.5	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a decreased function allele and one copy of a no function allele of the DPYD gene. Based on the genotype result this patient is predicted to be a DPYD Poor Metabolizer with a DPYD activity score of 0.5. This patient may be at risk for adverse drug reactions to medications that are metabolized by DPD (i.e. 5-fluorouracil, capecitabine, and tegafur) and a dose adjustment or alternative therapeutic agents may be indicated. Please consult a clinical pharmacist for more information about how DPD metabolic status influences drug selection and dosing.	2	\N
7756622	DPYD	Poor Metabolizer	0.0	Abnormal/Priority/High Risk	This result signifies that the patient has two copies of no function alleles of the DPYD gene. Based on the genotype result this patient is predicted to be a DPYD Poor Metabolizer with a DPYD activity score of 0. This patient may be at risk for adverse drug reactions to medications that are metabolized by DPD (i.e. 5-fluorouracil, capecitabine, and tegafur) and alternative therapeutic agents may be indicated. Please consult a clinical pharmacist for more information about how DPD metabolic status influences drug selection and dosing.	2	\N
7756862	G6PD	Deficient	n/a	Abnormal/Priority/High Risk	Based on the genotype result, this patient is predicted to be G6PD deficient and is at risk for developing hemolytic anemia when exposed to certain medications (such as dapsone, methylene blue, pegloticase, primaquine (at certain doses), rasburicase, tafenoquine, toluidine blue) or foods (such as fava beans). Please consult a clinical pharmacist for more information.	2	\N
7756955	G6PD	Deficient with CNSHA	n/a	Abnormal/Priority/High Risk	Based on the genotype result, this patient is predicted to be G6PD deficient with CNSHA and is at risk for developing or worsening hemolytic anemia when exposed to certain medications (such as dapsone, methylene blue, pegloticase, primaquine (at certain doses), rasburicase, tafenoquine, toluidine blue) or foods (such as fava beans). Please consult a clinical pharmacist for more information.	2	\N
7773525	G6PD	Indeterminate	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has an allele combination with uncertain and/or unknown function alleles. The expected phenotype for this patient cannot be determined currently based on genotype alone. A G6PD enzyme activity test is recommended to assess for G6PD deficiency. Please consult a clinical pharmacist for more specific information about how G6PD function influences drug dosing.	2	\N
7756855	G6PD	Normal	n/a	Normal Risk	Based on the genotype result, this patient is predicted to have normal G6PD enzyme activity. This means there is no reason to selectively avoid G6PD associated medications based on the G6PD status alone. Please consult a clinical pharmacist for more information.	2	\N
7757059	G6PD	Variable	n/a	Abnormal/Priority/High Risk	This patient carries one copy of a deficient G6PD allele and one copy of a normal G6PD allele. Due to X inactivation, patients who are heterozygous with one deficient allele and one normal allele may exhibit G6PD activity ranging from normal to deficient. A G6PD enzyme activity test is recommended to assess for G6PD deficiency. Please consult a clinical pharmacist for more information.	2	\N
7774645	MT-RNR1	increased risk of aminoglycoside-induced hearing loss	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has a copy of the MT-RNR1 [variant]. Based on this genotype result, the patient is predicted to be at increased risk of aminoglycoside-induced hearing loss. This means that the patient is likely to develop irreversible hearing loss if aminoglycosides (e.g. amikacin, gentamicin, tobramycin) are prescribed. Please consult a clinical pharmacist or Infectious Diseases Service for help selecting alternative therapies.	2	\N
7774650	MT-RNR1	normal risk of aminoglycoside-induced hearing loss	n/a	Normal/Routine/Low Risk	This result signifies that MT-RNR1 variants associated with aminoglycoside-induced hearing loss were not detected in this patient. Based on this genotype result, no change in aminoglycoside therapy is warranted. It should be noted that this result does not absolutely rule out the possibility of the patient developing ototoxicity with aminoglycoside use.	2	\N
7774653	MT-RNR1	uncertain risk of aminoglycoside-induced hearing loss	n/a	Normal/Routine/Low Risk	This result signifies that the patient has a copy of MT-RNR1 [variant]. At this time, the association of this allele with aminoglycoside-induced hearing loss is unknown/uncertain. Based on this genotype result, no change in aminoglycoside therapy is warranted. It should be noted that this result does not absolutely rule out the possibility of the patient developing ototoxicity with aminoglycoside use.	2	\N
7726097	ABCG2	Poor Function	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has two copies of a decreased function allele. Based on the genotype result, this patient is predicted to have poor ABCG2 function. This patient may be at a high risk for an adverse response to medications that are affected by ABCG2 (i.e. statins). To avoid an untoward drug response, dose adjustments or alternative therapeutic agents may be necessary for medications affected by ABCG2. Please consult a clinical pharmacist for more specific information about how ABCG2 function influences drug dosing.	3	{"Latino": 0.05035536, "American": 0.040000003, "European": 0.010732961, "Oceanian": 0.0419122, "East Asian": 0.09431041, "Near Eastern": 0.00426409, "Central/South Asian": 0.00868624, "Sub-Saharan African": 0.000034175762, "African American/Afro-Caribbean": 0.0012156549}
7726100	ABCG2	Decreased Function	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a normal function allele and one copy of a no decreased allele . Based on the genotype result, this patient is predicted to have decreased ABCG2 function. This patient may be at risk for an adverse response to medications that are affected by ABCG2. To avoid an untoward drug response, dose adjustments may be necessary for medications affected by ABCG2 (i.e. statins). Please consult a clinical pharmacist for more specific information about how ABCG2 function influences drug dosing.	3	{"Latino": 0.34808928, "American": 0.32000002, "European": 0.18573408, "Oceanian": 0.32562497, "East Asian": 0.4255792, "Near Eastern": 0.122071825, "Central/South Asian": 0.1690275, "Sub-Saharan African": 0.011623656, "African American/Afro-Caribbean": 0.06730118}
7726103	ABCG2	Normal Function	n/a	Normal/Routine/Low Risk	This result signifies that the patient has two copies of a normal function allele. Based on the genotype result, this patient is predicted to have normal ABCG2 function. This means that there is no reason to adjust the dose of most medications that are affected by ABCG2 on the basis of ABCG2 genetic status. Please consult a clinical pharmacist for more specific information about how ABCG2 function influences drug dosing.	3	{"Latino": 0.6015554, "American": 0.64000005, "European": 0.8035329, "Oceanian": 0.63246274, "East Asian": 0.4801104, "Near Eastern": 0.87366414, "Central/South Asian": 0.8222862, "Sub-Saharan African": 0.9883421, "African American/Afro-Caribbean": 0.9314832}
7774680	NAT2	Intermediate Metabolizer	n/a	Priority/High Risk	This result signifies that the patient has inherited one increased function allele and one decreased function allele. Based on the genotype result this patient is predicted to be an intermediate metabolizer of NAT2 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by NAT2. To avoid an untoward drug response, dose adjustments or alternative therapeutic agents may be necessary for medications metabolized by NAT2. Please consult a clinical pharmacist for more information about how NAT2 metabolic status influences drug selection and dosing.	2	\N
7774762	NAT2	Poor Metabolizer	n/a	Priority/High Risk	This result signifies that the patient has inherited two decreased function alleles. Based on the genotype result this patient is predicted to be a poor metabolizer of NAT2 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by NAT2. To avoid an untoward drug response, dose adjustments or alternative therapeutic agents may be necessary for medications metabolized by NAT2. Please consult a clinical pharmacist for more information about how NAT2 metabolic status influences drug selection and dosing.	2	\N
7775584	NAT2	Indeterminate	n/a	none	This result signifies that the patient has inhertied an allele combination with uncertain and/or unknown function alleles. The expected phenotype for this patient cannot be determined currently based on the NAT2 diplotype result. Please consult a clinical pharmacist for more specific information about how NAT2 function influences drug dosing.	2	\N
7726106	CACNA1S	Malignant Hyperthermia Susceptibility	n/a	Abnormal/Priority/High Risk	This result signifies that this patient has one copy of a variant [variant] associated with malignant hyperthermia susceptibility. Halogenated volatile anesthetics or depolarizing muscle relaxants are relatively contraindicated in persons with MHS. They should not be used, except in extraordinary circumstances where the benefits outweigh the risks. Please consult a MHS specialist or contact MHAUS (https://www.mhaus.org/healthcare-professionals/) for further information.	2	\N
7726114	CACNA1S	Uncertain Susceptibility	n/a	Normal Risk	Variation in RYR1 and/or CACNA1S genes is associated with increased risk of Malignant hyperthermia after administration of depolarizing muscle relaxants and potent volatile anesthetics. Although listed causative CACNA1S variants were NOT detected in this patient, it should be noted that this finding does not absolutely rule out the possibility of malignant hyperthermia. These results should be interpreted in the context of other genetic and clinical findings, family history and other laboratory data.	2	\N
7774675	NAT2	Rapid Metabolizer	n/a	Priority/High Risk	This result signifies that the patient has inherited two increased function alleles. Based on the genotype result this patient is predicted to be a rapid metabolizer of NAT2 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by NAT2. To avoid an untoward drug response, dose adjustments or alternative therapeutic agents may be necessary for medications metabolized by NAT2. Please consult a clinical pharmacist for more information about how NAT2 metabolic status influences drug selection and dosing.	2	\N
7776459	NUDT15	Normal Metabolizer	n/a	Normal/Routine/Low Risk	This result signifies that the patient has two copies of a normal function allele OR one copy of a normal function allele and one copy of a decreased function allele. Based on the genotype result this patient is predicted to be a NUDT15 normal metabolizer. There is no reason to selectively adjust the dose of most medications that are metabolized by NUDT15. Please consult a clinical pharmacist for more information about how NUDT15 metabolic status influences drug selection and dosing.	3	{"Latino": 0.94649667, "European": 0.98632336, "East Asian": 0.8551724, "Central/South Asian": 0.8657786}
7776465	NUDT15	Intermediate Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a normal function allele and one copy of a no function allele OR two copies of a decreased function allele. Based on the genotype result this patient is predicted to be a NUDT15 intermediate metabolizer. This patient may be at risk for an adverse reactions to medications that are metabolized by NUDT15 (eg thiopurines). To avoid an untoward drug response, dose adjustments or alternative therapeutic agents may be necessary for medications metabolized by NUDT15. Please consult a clinical pharmacist for more information about how NUDT15 metabolic status influences drug selection and dosing.	3	{"Latino": 0.0527679, "European": 0.013629507, "East Asian": 0.13750981, "Central/South Asian": 0.12932494}
7776482	NUDT15	Possible Intermediate Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of an uncertain function allele and one copy of a no function allele. Based on the genotype result this patient is predicted to be a NUDT15 possible intermediate metabolizer. This patient may be at risk for an adverse reactions to medications that are metabolized by NUDT15 (eg thiopurines). To avoid an untoward drug response, dose adjustments or alternative therapeutic agents may be necessary for medications metabolized by NUDT15. Please consult a clinical pharmacist for more information about how NUDT15 metabolic status influences drug selection and dosing.	3	{"Latino": 0.0, "European": 0.0, "East Asian": 0.0, "Central/South Asian": 0.0}
7776550	NUDT15	Poor Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has two copies of a no function allele OR one copy of a no function allele and one copy of a decreased function allele. Based on the genotype result this patient is predicted to be a NUDT15 poor metabolizer. This patient may be at a high risk for an adverse reactions to medications that are metabolized by NUDT15 (eg. thiopurines). To avoid an untoward drug response, dose adjustments or or alternative therapy may be necessary for medications metabolized by NUDT15. Please consult a clinical pharmacist for more information about how NUDT15 metabolic status influences drug selection and dosing.	3	{"Latino": 0.00073546247, "European": 0.000047192545, "East Asian": 0.0073177223, "Central/South Asian": 0.004896416}
7776641	NUDT15	Indeterminate	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a normal function allele and one copy of an uncertain function allele OR one copy of a decreased function allele and one copy of an uncertain function allele OR two copies of an uncertain function allele. The expected phenotype for this patient cannot be determined currently based on the NUDT15 diplotype result. If thiopurines are required and NUDT15 status is unknown, monitor closely for toxicity. Please consult a clinical pharmacist for more specific information about how NUDT15 function influences drug dosing.	3	{"Latino": 0.0, "European": 0.0, "East Asian": 0.0, "Central/South Asian": 0.0}
7726117	CFTR	ivacaftor responsive in CF patients	n/a	\N	\N	1	\N
7731579	CFTR	ivacaftor non-responsive in CF patients	n/a	\N	\N	1	\N
7808314	RYR1	Malignant Hyperthermia Susceptibility	n/a	Abnormal/Priority/High Risk	This result signifies that this patient has one copy of a variant [variant] associated with malignant hyperthermia susceptibility. Halogenated volatile anesthetics or depolarizing muscle relaxants are relatively contraindicated in persons with MHS. They should not be used, except in extraordinary circumstances where the benefits outweigh the risks. Please consult a MHS specialist or contact MHAUS (https://www.mhaus.org/healthcare-professionals/) for further information.	2	\N
7776684	RYR1	Uncertain Susceptibility	n/a	Normal Risk	Variation in RYR1 and/or CACNA1S genes is associated with increased risk of Malignant hyperthermia after administration of depolarizing muscle relaxants and potent volatile anesthetics. Although listed causative RYR1 variants were NOT detected in this patient, it should be noted that this finding does not absolutely rule out the possibility of malignant hyperthermia. These results should be interpreted in the context of other genetic and clinical findings, family history and other laboratory data.	2	\N
7736569	CYP2D6	Ultrarapid Metabolizer	2.75	Abnormal/Priority/High Risk	This result signifies that this patient has [X copies of a normal function allele (*_xN)] [X copies of a decreased function allele (*_)] [X copies of a no function allele (*_)]. Based on the genotype result this patient is predicted to be an ultrarapid metabolizer of CYP2D6 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2D6. To avoid an untoward drug response, dose adjustments may be necessary for medications metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.0, "American": 0.0, "European": 0.0, "Oceanian": 0.0, "East Asian": 0.0, "Near Eastern": 0.0, "Central/South Asian": 0.0, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": 0.0}
7836728	HLA-A	*31:01 negative	n/a	Routine/Low-Risk	The HLA-A*31:01 allele, which is associated with severe cutaneous adverse reactions among patients taking certain aromatic anticonvulsants, was not detected in this patient. No change in therapy is warranted based on these results. It should be noted that a negative HLA-A*31:01 result does not absolutely rule out the possibility of an adverse drug reaction. Please consult a clinical pharmacist for more information.	1	\N
7736755	CYP2D6	Normal Metabolizer	2.25	Normal/Routine/ Low Risk	This result signifies that this patient has two copies of a normal function allele (*_x2) and one copy of decreased function allele with an activity value of 0.25 (*_). Based on the genotype result this patient is predicted to be a normal metabolizer of CYP2D6 substrates. There is no reason to selectively adjust the dose of most medications that are metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.005172111, "American": 0.0031386076, "European": 0.004804125, "Oceanian": 0.021296859, "East Asian": 0.0072455397, "Near Eastern": 0.029094387, "Central/South Asian": 0.005050826, "Sub-Saharan African": 0.0048336256, "African American/Afro-Caribbean": 0.004428509}
7737116	CYP2D6	Normal Metabolizer	1.75	Normal/Routine/ Low Risk	This result signifies that this patient has three copies of *41 (*41x3) and one copy of a normal function allele (*_) or [2 copies of a decreased function allele with an activity value of 0.5 (*_x2)]. Based on the genotype result this patient is predicted to be a normal metabolizer of CYP2D6 substrates. There is no reason to selectively adjust the dose of most medications that are metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.0, "American": 0.0, "European": 0.0, "Oceanian": 0.0, "East Asian": 0.0, "Near Eastern": 0.0, "Central/South Asian": 0.0, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": 0.0}
7737113	CYP2D6	Normal Metabolizer	1.5	Normal/Routine/ Low Risk	This result signifies that this patient has [1 copy of a normal function allele (*_)] [X copies of a decreased function allele (*_)] [X copies of a no function allele (*_)]. Based on the genotype result this patient is predicted to be a normal metabolizer of CYP2D6 substrates. There is no reason to selectively adjust the dose of most medications that are metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.051568672, "American": 0.012521543, "European": 0.010339902, "Oceanian": 0.00143701, "East Asian": 0.017062929, "Near Eastern": 0.045171212, "Central/South Asian": 0.0029989334, "Sub-Saharan African": 0.23161727, "African American/Afro-Caribbean": 0.23827769}
7737149	CYP2D6	Intermediate Metabolizer	1.0	Abnormal/Priority/High Risk	This result signifies that this patient has [1 copy of a normal function allele (*_)] [X copies of a decreased function allele (*_)] [X copies of a no function allele (*_)]. Based on the genotype result this patient is predicted to be an intermediate metabolizer of CYP2D6 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2D6. To avoid an untoward drug response, dose adjustments may be necessary for medications metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.2278144, "American": 0.21460281, "European": 0.28533316, "Oceanian": 0.077126324, "East Asian": 0.070599586, "Near Eastern": 0.14959782, "Central/South Asian": 0.17827679, "Sub-Saharan African": 0.20079781, "African American/Afro-Caribbean": 0.2080644}
7737162	CYP2D6	Intermediate Metabolizer	0.75	Abnormal/Priority/High Risk	This result signifies that this patient has has three copies of *41 (*41x3) and one copy of a no function allele (*_) OR [1 copy of a decreased function allele with an activity value of 0.25 (*_)] and [1 copy of a decreased function allele with an activity value of 0.5 (*_)] or [2 copies of a decreased function allele with an activity value of 0.25 (*_x2)] . Based on the genotype result this patient is predicted to be an intermediate metabolizer of CYP2D6 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2D6. To avoid an untoward drug response, dose adjustments may be necessary for medications metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.0074723335, "American": 0.00080644403, "European": 0.0025628314, "Oceanian": 0.00018655165, "East Asian": 0.020004882, "Near Eastern": 0.02042247, "Central/South Asian": 0.0010252715, "Sub-Saharan African": 0.05760366, "African American/Afro-Caribbean": 0.041067164}
7739963	CYP2D6	Poor Metabolizer	0.0	Abnormal/Priority/High Risk	This result signifies that the patient has two copies of a no function allele (*_/*_). Based on the genotype result this patient is predicted to be a poor metabolizer of CYP2D6 substrates. This patient may be at a high risk for an adverse or poor response to medications that are metabolized by CYP2D6. To avoid an untoward drug response, dose adjustments or alternative therapeutic agents may be necessary for medications metabolized by the CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.0311798, "American": 0.020160662, "European": 0.065024786, "Oceanian": 0.0031239481, "East Asian": 0.008123729, "Near Eastern": 0.021957064, "Central/South Asian": 0.023507897, "Sub-Saharan African": 0.020398295, "African American/Afro-Caribbean": 0.023474354}
7836731	HLA-A	*31:01 positive	n/a	Priority/High-Risk	This result signifies that the patient has one or two copies of HLA-A*31:01. Patients with this genotype are at increased risk of severe cutaneous adverse reactions, including Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN), drug reaction with eosinophilia and systemic symptoms (DRESS), and maculopapular exanthema (MPE), with certain aromatic anticonvulsants (e.g., carbamazepine). Alternative therapy may be warranted. Please consult a clinical pharmacist for more information.	1	\N
7836734	HLA-B	*15:02 negative	n/a	Routine/Low-Risk	The HLA-B*15:02 allele, which is associated with severe cutaneous adverse reactions among patients taking certain aromatic anticonvulsants, was not detected in this patient. No change in therapy is warranted based on these results. It should be noted that a negative HLA-B*15:02 result does not absolutely rule out the possibility of an adverse drug reaction. Please consult a clinical pharmacist for more information.	1	\N
7836737	HLA-B	*15:02 positive	n/a	Priority/High-Risk	This result signifies that the patient has one or two copies of HLA-B*15:02. Patients with this genotype are at increased risk of severe cutaneous adverse reactions, including Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN), with certain aromatic anticonvulsants (e.g., carbamazepine, oxcarbazepine, phenytoin/fosphenytoin). Alternative therapy may be warranted. Please consult a clinical pharmacist for more information.	1	\N
7836740	HLA-B	*57:01 negative	n/a	Normal/Routine/Low Risk	The HLA-B*57:01 allele, associated with abacavir hypersensitivity, was not detected in this patient. The patient may be prescribed abacavir. Please refer to the hospital formulary guidelines for specific dosing information. It should be noted that a negative HLA-B*57:01 result does not absolutely rule out the possibility of some form of abacavir hypersensitivity. Administration of abacavir therapy requires close observation including immediate discontinuation of therapy should any signs or symptoms of hypersensitivity develop.	1	\N
7836743	HLA-B	*57:01 positive	n/a	Abnormal/Priority/High Risk	The HLA-B*57:01 allele, associated with abacavir hypersensitivity, was detected in this patient. HLA-B*5701 positive patients should NOT be prescribed abacavir.	1	\N
7836746	HLA-B	*58:01 negative	n/a	Normal/Routine/Low Risk	The HLA-B*58:01 allele, associated with allopurinol hypersensitivity, was not detected in this patient. Allopurinol can be used per standard dosing guidelines. Patients should be monitored closely for any signs of sensitivity reactions, especially those patients receiving allopurinol (of >300 mg/day), concomitant medications (i.e. thiazide diuretics or penicillin/cephalosporin) or with medical conditions (i.e. chronic kidney disease) that increase the non-genetic risk for allopurinol-related hypersensitivity reactions.	1	\N
7836749	HLA-B	*58:01 positive	n/a	Abnormal/Priority/High Risk	The HLA-B*58:01 allele, associated with allopurinol hypersensitivity, was detected in this patient. Allopurinol is contraindicated.	1	\N
7731585	CYP2B6	Rapid Metabolizer	n/a	Normal/Routine/Low Risk	This result signifies that the patient has one copy of a normal function allele and one copy of an increased function allele. Based on the genotype result this patient is predicted to be a rapid metabolizer of CYP2B6 substrates. There is no reason to selectively adjust the dose of most medications that are metabolized by CYP2B6. Please consult a clinical pharmacist for more information about how CYP2B6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.1231214, "European": 0.05357082, "Oceanian": 0.0, "East Asian": 0.11734093, "Near Eastern": 0.112112, "Central/South Asian": 0.12859802, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": 0.011896482}
7731616	CYP2B6	Intermediate Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a normal function allele and one copy of a no function allele OR one copy of a normal function allele and one copy of a decreased function allele OR one copy of an increased function allele and one copy of a no function allele OR one copy of an increased function allele and one copy of a decreased function allele. Based on the genotype result this patient is predicted to be an intermediate metabolizer of CYP2B6 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2B6. To avoid an untoward drug response, dose adjustments or alternative therapeutic agents may be necessary for medications metabolized by CYP2B6. Please consult a clinical pharmacist for more information about how CYP2B6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.42165288, "European": 0.37952113, "Oceanian": 0.46080005, "East Asian": 0.32628936, "Near Eastern": 0.459102, "Central/South Asian": 0.36526063, "Sub-Saharan African": 0.36808127, "African American/Afro-Caribbean": 0.4660738}
7836598	TPMT	Indeterminate	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a normal function allele and one copy of an uncertain or unknown function allele OR one copy of a decreased function allele and one copy of an uncertain or unknown function allele OR two copies of an uncertain or unknown function allele. The expected phenotype for this patient cannot be determined currently based on the TPMT diplotype result. Consider evaluating TPMT erythrocyte activity to assess TPMT phenotype. Erythrocyte TPMT activity test results can be falsely low at diagnosis of leukemia and is unreliable in the case of recent red blood cell transfusions. If thiopurines are required and TPMT status is unknown, monitor closely for toxicity. Please consult a clinical pharmacist for more specific information about how TPMT function influences drug dosing.	3	{"Latino": 0.0032013063, "European": 0.0013079308, "East Asian": 0.000104039, "Near Eastern": 0.0, "Central/South Asian": 0.0, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": 0.06207684}
7733067	CYP2C19	Poor Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has two copies of a no function allele. Based on the genotype result this patient is predicted to be a poor metabolizer of CYP2C19 substrates. This patient may be at a high risk for an adverse or poor response to medications that are metabolized by CYP2C19. To avoid an untoward drug response, dose adjustments or or alternative therapy may be necessary for medications metabolized by the CYP2C19. Please consult a clinical pharmacist for more information about how CYP2C19 metabolic status influences drug selection and dosing.	3	{"Latino": 0.011408395, "American": 0.014819587, "European": 0.02387743, "Oceanian": 0.5713864, "East Asian": 0.12978691, "Near Eastern": 0.018584846, "Central/South Asian": 0.08156806, "Sub-Saharan African": 0.036714304, "African American/Afro-Caribbean": 0.040512204}
7732779	CYP2C19	Ultrarapid Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has two copies of an increased function allele. Based on the genotype result this patient is predicted to be an ultrarapid metabolizer of CYP2C19 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2C19. To avoid an untoward drug response, dose adjustments or alternative therapeutic agents may be necessary for medications metabolized by CYP2C19. Please consult a clinical pharmacist for more information about how CYP2C19 metabolic status influences drug selection and dosing.	3	{"Latino": 0.02774172, "American": 0.0074097984, "European": 0.04641379, "Oceanian": 0.003249, "East Asian": 0.00042194634, "Near Eastern": 0.036642652, "Central/South Asian": 0.029163336, "Sub-Saharan African": 0.030045323, "African American/Afro-Caribbean": 0.042943195}
7732821	CYP2C19	Likely Intermediate Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a normal function allele and one copy of a decreased function allele OR one copy of an increased function allele and one copy of a decreased function allele OR two copies of a decreased function allele. Based on the genotype result this patient MAY be an intermediate metabolizer of CYP2C19 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2C19. To avoid an untoward drug response, dose adjustments or alternative therapeutic agents may be necessary for medications metabolized by CYP2C19. Please consult a clinical pharmacist for more information about how CYP2C19 metabolic status influences drug selection and dosing.	3	{"Latino": 0.003709162, "American": 0.0, "European": 0.0011160374, "Oceanian": 0.0, "East Asian": 0.00076989824, "Near Eastern": 0.0, "Central/South Asian": 0.0, "Sub-Saharan African": 0.042863965, "African American/Afro-Caribbean": 0.027788177}
7734052	CYP2C9	Poor Metabolizer	0.0	Abnormal/Priority/High Risk	This result signifies that the patient has two copies of no function alleles. Based on the genotype result, this patient is predicted to be a CYP2C9 poor metabolizer. This patient may be at high risk for an adverse response to medications that are affected by CYP2C9. Please consult a clinical pharmacist for more specific information about how CYP2C9 intermediate metabolizer status influences drug dosing.	3	{"Latino": 0.0017415384, "American": 0.00090327376, "European": 0.0057798154, "Oceanian": 0.00024261088, "East Asian": 0.0028714235, "Near Eastern": 0.007066085, "Central/South Asian": 0.012135133, "Sub-Saharan African": 0.0003982905, "African American/Afro-Caribbean": 0.00048520204}
7741141	CYP2D6	Indeterminate	n/a	none	This result signifies that the patient has an allele combination with uncertain and/or unknown function alleles. The expected phenotype for this patient cannot be determined currently based on the CYP2D6 diplotype result. Please consult a clinical pharmacist for more specific information about how CYP2D6 function influences drug dosing.	3	{"Latino": 0.041558996, "American": 0.02454997, "European": 0.03725156, "Oceanian": 0.087338224, "East Asian": 0.066782884, "Near Eastern": 0.03744279, "Central/South Asian": 0.09993659, "Sub-Saharan African": 0.09009597, "African American/Afro-Caribbean": 0.038868744}
7736339	CYP2D6	Ultrarapid Metabolizer	≥6.0	Abnormal/Priority/High Risk	This result signifies that this patient has [X copies of a normal function allele (*_xN)] [X copies of a decreased function allele (*_)] [X copies of a no function allele (*_)]. Based on the genotype result this patient is predicted to be an ultrarapid metabolizer of CYP2D6 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2D6. To avoid an untoward drug response, dose adjustments may be necessary for medications metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.0000010000001, "American": 0.0000010000001, "European": 0.0000028470035, "Oceanian": 0.0, "East Asian": 0.0000010000001, "Near Eastern": 0.0, "Central/South Asian": 0.0, "Sub-Saharan African": 0.000025000001, "African American/Afro-Caribbean": 0.0}
7736358	CYP2D6	Ultrarapid Metabolizer	≥3.75	Abnormal/Priority/High Risk	This result signifies that this patient has [X copies of a normal function allele (*_xN)] [X copies of a decreased function allele (*_)] [X copies of a no function allele (*_)]. Based on the genotype result this patient is predicted to be an ultrarapid metabolizer of CYP2D6 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2D6. To avoid an untoward drug response, dose adjustments may be necessary for medications metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.0, "American": 0.0, "European": 0.0, "Oceanian": 0.0, "East Asian": 0.0, "Near Eastern": 0.0, "Central/South Asian": 0.0, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": 0.0}
7736448	CYP2D6	Ultrarapid Metabolizer	≥3.0	Abnormal/Priority/High Risk	This result signifies that this patient has [X copies of a normal function allele (*_xN)] [X copies of a decreased function allele (*_)] [X copies of a no function allele (*_)]. Based on the genotype result this patient is predicted to be an ultrarapid metabolizer of CYP2D6 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2D6. To avoid an untoward drug response, dose adjustments may be necessary for medications metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.00035315607, "American": 0.0002839765, "European": 0.0008605249, "Oceanian": 0.0, "East Asian": 0.00018026348, "Near Eastern": 0.0, "Central/South Asian": 0.0, "Sub-Saharan African": 0.001428226, "African American/Afro-Caribbean": 0.0}
7739433	CYP2D6	Intermediate Metabolizer	0.25	Abnormal/Priority/High Risk	This result signifies that this patient has one copy of a decreased function allele with an activity value of 0.25 (*_) and one copy of a no function allele (*_). Based on the genotype result this patient is predicted to be an intermediate metabolizer of CYP2D6 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2D6. To avoid an untoward drug response, dose adjustments may be necessary for medications metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.03277562, "American": 0.0138169695, "European": 0.07070104, "Oceanian": 0.010012345, "East Asian": 0.08220821, "Near Eastern": 0.06670452, "Central/South Asian": 0.060946763, "Sub-Saharan African": 0.027220901, "African American/Afro-Caribbean": 0.024385082}
7736675	CYP2D6	Ultrarapid Metabolizer	2.5	Abnormal/Priority/High Risk	This result signifies that this patient has [X copies of a normal function allele (*_xN)] [X copies of a decreased function allele (*_)]. Based on the genotype result this patient is predicted to be an ultrarapid metabolizer of CYP2D6 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2D6. To avoid an untoward drug response, dose adjustments may be necessary for medications metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.0022434974, "American": 0.0005345896, "European": 0.0003203256, "Oceanian": 0.00024761492, "East Asian": 0.00034846712, "Near Eastern": 0.005864233, "Central/South Asian": 0.00006554563, "Sub-Saharan African": 0.015329994, "African American/Afro-Caribbean": 0.01435911}
7736823	CYP2D6	Normal Metabolizer	2.0	Normal/Routine/ Low Risk	This result signifies that this patient has [X copies of a normal function allele (*_xN)] [X copies of a decreased function allele (*_)] [X copies of a no function allele (*_)]. Based on the genotype result this patient is predicted to be a normal metabolizer of CYP2D6 substrates. There is no reason to selectively adjust the dose of most medications that are metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.42007107, "American": 0.57988566, "European": 0.32166475, "Oceanian": 0.48931405, "East Asian": 0.1527359, "Near Eastern": 0.2670007, "Central/South Asian": 0.34187043, "Sub-Saharan African": 0.15406683, "African American/Afro-Caribbean": 0.22171879}
7737134	CYP2D6	Normal Metabolizer	1.25	Normal/Routine/ Low Risk	This result signifies that this patient has [1 copy of a normal function allele (*_)] or [2 copies of a decreased function allele with an activity value of 0.5 (*_x2)] and [1 copy of a decreased function allele with an activity value of 0.25 (*_)] OR *41x3 and [1 copy of a decreased function allele with an activity value of 0.5 (*_)] or [2 copies of a decreased function allele with an activity value of 0.25 (*_x2)]. Based on the genotype result this patient is predicted to be a normal metabolizer of CYP2D6 substrates. There is no reason to selectively adjust the dose of most medications that are metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.11888533, "American": 0.07351474, "European": 0.15507403, "Oceanian": 0.12359433, "East Asian": 0.3547828, "Near Eastern": 0.22410923, "Central/South Asian": 0.23109229, "Sub-Saharan African": 0.073030114, "African American/Afro-Caribbean": 0.07348749}
7738740	CYP2D6	Intermediate Metabolizer	0.5	Abnormal/Priority/High Risk	This result signifies that this patient has [1 copy of a decreased function allele with an activity value of 0.5 (*_)] or [2 copies of a decreased function allele with an activity value of 0.25 (*_x2)] and one copy of a no function allele (*_) OR two copies for a decreased function allele with an activity value of 0.25 (*_/*_). Based on the genotype result this patient is predicted to be an intermediate metabolizer of CYP2D6 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2D6. To avoid an untoward drug response, dose adjustments may be necessary for medications metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.022830304, "American": 0.0047207433, "European": 0.023932345, "Oceanian": 0.008138877, "East Asian": 0.21193053, "Near Eastern": 0.06410619, "Central/South Asian": 0.040293686, "Sub-Saharan African": 0.0954133, "African American/Afro-Caribbean": 0.08539959}
7834691	SLCO1B1	Normal Function	n/a	Normal/Routine/Low Risk	This result signifies that the patient has two copies of a normal function allele. Based on the genotype result, this patient is predicted to have normal SLCO1B1 function. This means that there is no reason to adjust the dose of most medications that are affected by SLCO1B1 on the basis of SLCO1B1 genetic status. Please consult a clinical pharmacist for more specific information about how SLCO1B1 function influences drug dosing.	3	{"American": 0.5776, "European": 0.6564144, "Oceanian": 1.0, "East Asian": 0.75683165, "Near Eastern": 0.64000005, "Central/South Asian": 0.8648222, "Sub-Saharan African": 0.94491136, "African American/Afro-Caribbean": 0.98010004}
7834841	SLCO1B1	Possible Decreased Function	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a uncertain or unknown function allele (*_) and one copy of a no function allele (*_). Based on the genotype result, this patient is predicted to have possible decreased SLCO1B1 function. This patient may be at risk for an adverse response to medications that are affected by SLCO1B1. To avoid an untoward drug response, dose adjustments may be necessary for medications affected by SLCO1B1 (i.e. statins). Please consult a clinical pharmacist for more specific information about how SLCO1B1 function influences drug dosing.	3	{"American": 0.0, "European": 0.00026362084, "Oceanian": 0.0, "East Asian": 0.0011306308, "Near Eastern": 0.0, "Central/South Asian": 0.0000418451, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": 0.0}
7835429	TPMT	Intermediate Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a normal function allele and one copy of a no function allele OR two copies of a decreased function allele. Based on the genotype result this patient is predicted to be a TPMT intermediate metabolizer. This patient may be at risk for an adverse reactions to medications that are metabolized by TPMT (eg. thiopurines). To avoid an untoward drug response, dose adjustments or alternative therapeutic agents may be necessary for medications metabolized by TPMT. However, thiopurines can be affected by a patient's TPMT and NUDT15 phenotype. Please consult a clinical pharmacist for more information about how TPMT and NUDT15 metabolic status influences drug selection and dosing.	3	{"Latino": 0.10125442, "European": 0.08729337, "East Asian": 0.039815668, "Near Eastern": 0.06641302, "Central/South Asian": 0.03638162, "Sub-Saharan African": 0.1010342, "African American/Afro-Caribbean": 0.06894094}
7835471	TPMT	Possible Intermediate Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of an uncertain or unknown function allele and one copy of a no function allele OR one copy of a no function allele and one copy of a decreased function allele. Based on the genotype result this patient has a priority result (TPMT possible intermediate metabolizer) because their activity is not likely to be any higher than that of an intermediate metabolizer; if the uncertain/unknown function allele is also low, activity may be even lower than that of an intermediate metabolizer. This patient may be at risk for an adverse reactions to medications that are metabolized by TPMT (eg. thiopurines). To avoid an untoward drug response, dose adjustments or alternative therapeutic agents may be necessary for medications metabolized by TPMT. However, thiopurines can be affected by a patient's TPMT and NUDT15 phenotype. Please consult a clinical pharmacist for more information about how TPMT and NUDT15metabolic status influences drug selection and dosing.	3	{"Latino": 0.0003095076, "European": 0.00007234227, "East Asian": 0.0000021581852, "Near Eastern": 0.0, "Central/South Asian": 0.0000034757581, "Sub-Saharan African": 0.0026164071, "African American/Afro-Caribbean": 0.0029308118}
\.


--
-- Data for Name: gene_result_diplotype; Type: TABLE DATA; Schema: cpic; Owner: -
--

COPY cpic.gene_result_diplotype (id, functionphenotypeid, diplotype, diplotypekey, frequency) FROM stdin;
7821507	7815081	c.7124G>C/c.14051T>C	{"RYR1": {"c.7124G>C": 1, "c.14051T>C": 1}}	\N
7821508	7815081	c.1422G>T/c.14497C>T	{"RYR1": {"c.1422G>T": 1, "c.14497C>T": 1}}	\N
7821509	7815081	c.7043A>G/c.13673G>A	{"RYR1": {"c.7043A>G": 1, "c.13673G>A": 1}}	\N
7821510	7815081	c.7090T>G/c.12028G>A	{"RYR1": {"c.7090T>G": 1, "c.12028G>A": 1}}	\N
7821511	7815081	c.487C>T/c.6847A>C	{"RYR1": {"c.487C>T": 1, "c.6847A>C": 1}}	\N
7821512	7815081	c.7282G>A/c.10556C>T	{"RYR1": {"c.7282G>A": 1, "c.10556C>T": 1}}	\N
7821513	7815081	c.946C>T/c.14210G>A	{"RYR1": {"c.946C>T": 1, "c.14210G>A": 1}}	\N
7821514	7815081	c.982C>T/c.8600T>A	{"RYR1": {"c.982C>T": 1, "c.8600T>A": 1}}	\N
7821515	7815081	c.493G>A/c.7007G>A	{"RYR1": {"c.493G>A": 1, "c.7007G>A": 1}}	\N
7821516	7815081	c.3166G>C/c.3418C>T	{"RYR1": {"c.3166G>C": 1, "c.3418C>T": 1}}	\N
7821517	7815081	c.1597C>T/c.11958C>G	{"RYR1": {"c.1597C>T": 1, "c.11958C>G": 1}}	\N
7821518	7815081	c.6488G>C/c.7075C>T	{"RYR1": {"c.6488G>C": 1, "c.7075C>T": 1}}	\N
7821519	7815081	c.7354C>T/c.12848A>T	{"RYR1": {"c.7354C>T": 1, "c.12848A>T": 1}}	\N
7821520	7815081	c.12700G>C/c.14471T>C	{"RYR1": {"c.12700G>C": 1, "c.14471T>C": 1}}	\N
7821521	7815081	c.5024T>C/c.7522C>T	{"RYR1": {"c.5024T>C": 1, "c.7522C>T": 1}}	\N
7821522	7815081	c.1021G>C/c.3172G>A	{"RYR1": {"c.1021G>C": 1, "c.3172G>A": 1}}	\N
7821523	7815081	c.14509C>G/c.14545G>A	{"RYR1": {"c.14509C>G": 1, "c.14545G>A": 1}}	\N
7821524	7815081	c.1841G>T/c.10042C>T	{"RYR1": {"c.1841G>T": 1, "c.10042C>T": 1}}	\N
7821525	7815081	c.1201C>T/c.7085A>G	{"RYR1": {"c.1201C>T": 1, "c.7085A>G": 1}}	\N
7821526	7815081	c.1615T>C/c.14825G>T	{"RYR1": {"c.1615T>C": 1, "c.14825G>T": 1}}	\N
7821527	7815081	c.487C>T/c.3527C>T	{"RYR1": {"c.487C>T": 1, "c.3527C>T": 1}}	\N
7821528	7815081	c.6617C>T/c.6743G>A	{"RYR1": {"c.6617C>T": 1, "c.6743G>A": 1}}	\N
7821529	7815081	c.3166G>C/c.13934G>A	{"RYR1": {"c.3166G>C": 1, "c.13934G>A": 1}}	\N
7821530	7815081	c.7060G>A/c.14458G>T	{"RYR1": {"c.7060G>A": 1, "c.14458G>T": 1}}	\N
7821531	7815081	c.7310C>T/c.8527T>C	{"RYR1": {"c.7310C>T": 1, "c.8527T>C": 1}}	\N
7821532	7815081	c.1201C>G/c.6487C>T	{"RYR1": {"c.1201C>G": 1, "c.6487C>T": 1}}	\N
7821533	7815081	c.6304G>C/c.14627A>G	{"RYR1": {"c.6304G>C": 1, "c.14627A>G": 1}}	\N
7821534	7815081	c.6487C>T/c.12355A>T	{"RYR1": {"c.6487C>T": 1, "c.12355A>T": 1}}	\N
7821535	7815081	c.6502G>A/c.13934G>A	{"RYR1": {"c.6502G>A": 1, "c.13934G>A": 1}}	\N
7821536	7815081	c.982C>T/c.8005G>A	{"RYR1": {"c.982C>T": 1, "c.8005G>A": 1}}	\N
7821537	7815081	c.7879G>C/c.14270G>A	{"RYR1": {"c.7879G>C": 1, "c.14270G>A": 1}}	\N
7821538	7815081	c.6617C>T/c.9850T>A	{"RYR1": {"c.6617C>T": 1, "c.9850T>A": 1}}	\N
7821539	7815081	c.1024G>A/c.3166G>C	{"RYR1": {"c.1024G>A": 1, "c.3166G>C": 1}}	\N
7821540	7815081	c.467G>A/c.7304G>A	{"RYR1": {"c.467G>A": 1, "c.7304G>A": 1}}	\N
7821541	7815081	c.131G>A/c.1630G>T	{"RYR1": {"c.131G>A": 1, "c.1630G>T": 1}}	\N
7821542	7815081	c.12532G>A/c.14918C>T	{"RYR1": {"c.12532G>A": 1, "c.14918C>T": 1}}	\N
7821543	7815081	c.8198G>A/c.14803G>A	{"RYR1": {"c.8198G>A": 1, "c.14803G>A": 1}}	\N
7821544	7815081	c.7304G>A/c.7528T>C	{"RYR1": {"c.7304G>A": 1, "c.7528T>C": 1}}	\N
7821545	7815081	c.7060G>A/c.14458G>A	{"RYR1": {"c.7060G>A": 1, "c.14458G>A": 1}}	\N
7821546	7815081	c.3166G>A/c.14512C>G	{"RYR1": {"c.3166G>A": 1, "c.14512C>G": 1}}	\N
7821547	7815081	c.6377G>A/c.7043A>G	{"RYR1": {"c.6377G>A": 1, "c.7043A>G": 1}}	\N
7821548	7815081	c.1024G>A/c.1565A>C	{"RYR1": {"c.1024G>A": 1, "c.1565A>C": 1}}	\N
7821549	7815081	c.529C>T/c.6304G>C	{"RYR1": {"c.529C>T": 1, "c.6304G>C": 1}}	\N
7821550	7815081	c.467G>A/c.7304G>T	{"RYR1": {"c.467G>A": 1, "c.7304G>T": 1}}	\N
7821551	7815081	c.1201C>T/c.6635T>A	{"RYR1": {"c.1201C>T": 1, "c.6635T>A": 1}}	\N
7821552	7815081	c.4763C>T/c.7300G>A	{"RYR1": {"c.4763C>T": 1, "c.7300G>A": 1}}	\N
7821553	7815081	c.1024G>A/c.1565A>G	{"RYR1": {"c.1024G>A": 1, "c.1565A>G": 1}}	\N
7821554	7815081	c.6502G>A/c.10237A>T	{"RYR1": {"c.6502G>A": 1, "c.10237A>T": 1}}	\N
7821555	7815081	c.1209C>G/c.7361G>A	{"RYR1": {"c.1209C>G": 1, "c.7361G>A": 1}}	\N
7821556	7815081	c.5132A>G/c.7522C>T	{"RYR1": {"c.5132A>G": 1, "c.7522C>T": 1}}	\N
7821557	7815081	c.7085A>G/c.7879G>C	{"RYR1": {"c.7085A>G": 1, "c.7879G>C": 1}}	\N
7821558	7815081	c.12355A>T/c.14497C>T	{"RYR1": {"c.12355A>T": 1, "c.14497C>T": 1}}	\N
7821559	7815081	c.1202G>A/c.6544A>T	{"RYR1": {"c.1202G>A": 1, "c.6544A>T": 1}}	\N
7821560	7815081	c.7523G>A/c.14002C>T	{"RYR1": {"c.7523G>A": 1, "c.14002C>T": 1}}	\N
7821561	7815081	c.103T>C/c.212C>A	{"RYR1": {"c.103T>C": 1, "c.212C>A": 1}}	\N
7821562	7815081	c.10252A>G/c.14512C>G	{"RYR1": {"c.10252A>G": 1, "c.14512C>G": 1}}	\N
7821563	7815081	c.1840C>T/c.14582G>A	{"RYR1": {"c.1840C>T": 1, "c.14582G>A": 1}}	\N
7821564	7815081	c.6838G>A/c.9676G>C	{"RYR1": {"c.6838G>A": 1, "c.9676G>C": 1}}	\N
7821565	7815081	c.3667G>A/c.7123G>A	{"RYR1": {"c.3667G>A": 1, "c.7123G>A": 1}}	\N
7821566	7815081	c.7317G>C/c.14477C>T	{"RYR1": {"c.7317G>C": 1, "c.14477C>T": 1}}	\N
7821567	7815081	c.14458G>T/c.14918C>T	{"RYR1": {"c.14458G>T": 1, "c.14918C>T": 1}}	\N
7821568	7815081	c.1654C>T/c.12413T>C	{"RYR1": {"c.1654C>T": 1, "c.12413T>C": 1}}	\N
7821569	7815081	c.6487C>T/c.6743G>A	{"RYR1": {"c.6487C>T": 1, "c.6743G>A": 1}}	\N
7821570	7815081	c.7282G>A/c.7307G>A	{"RYR1": {"c.7282G>A": 1, "c.7307G>A": 1}}	\N
7821571	7815081	c.1021G>A/c.4747C>T	{"RYR1": {"c.1021G>A": 1, "c.4747C>T": 1}}	\N
7821572	7815081	c.533A>G/c.8926C>T	{"RYR1": {"c.533A>G": 1, "c.8926C>T": 1}}	\N
7821573	7815081	c.7076G>A/c.8638G>A	{"RYR1": {"c.7076G>A": 1, "c.8638G>A": 1}}	\N
7821574	7815081	c.7354C>T/c.10891G>T	{"RYR1": {"c.7354C>T": 1, "c.10891G>T": 1}}	\N
7821575	7815081	c.947G>T/c.7304G>T	{"RYR1": {"c.947G>T": 1, "c.7304G>T": 1}}	\N
7821576	7815081	c.4775C>T/c.7372C>T	{"RYR1": {"c.4775C>T": 1, "c.7372C>T": 1}}	\N
7821577	7815081	c.3166G>C/c.6548G>A	{"RYR1": {"c.3166G>C": 1, "c.6548G>A": 1}}	\N
7821578	7815081	c.7060G>A/c.13702C>G	{"RYR1": {"c.7060G>A": 1, "c.13702C>G": 1}}	\N
7821579	7815081	c.6847A>C/c.14209C>T	{"RYR1": {"c.6847A>C": 1, "c.14209C>T": 1}}	\N
7821580	7815081	c.7112A>G/c.14545G>A	{"RYR1": {"c.7112A>G": 1, "c.14545G>A": 1}}	\N
7821581	7815081	c.7372C>T/c.12848A>T	{"RYR1": {"c.7372C>T": 1, "c.12848A>T": 1}}	\N
7821582	7815081	c.947G>T/c.7304G>A	{"RYR1": {"c.947G>T": 1, "c.7304G>A": 1}}	\N
7821583	7815081	c.7522C>T/c.12689T>G	{"RYR1": {"c.7522C>T": 1, "c.12689T>G": 1}}	\N
7821584	7815081	c.130C>T/c.5441T>A	{"RYR1": {"c.130C>T": 1, "c.5441T>A": 1}}	\N
7821585	7815081	c.5440A>G/c.6488G>T	{"RYR1": {"c.5440A>G": 1, "c.6488G>T": 1}}	\N
7821586	7815081	c.7361G>A/c.8926C>T	{"RYR1": {"c.7361G>A": 1, "c.8926C>T": 1}}	\N
7821587	7815081	c.38T>G/c.14197T>G	{"RYR1": {"c.38T>G": 1, "c.14197T>G": 1}}	\N
7821588	7815081	c.7084G>A/c.11813G>A	{"RYR1": {"c.7084G>A": 1, "c.11813G>A": 1}}	\N
7821589	7815081	c.6838G>A/c.7307G>A	{"RYR1": {"c.6838G>A": 1, "c.7307G>A": 1}}	\N
7821590	7815081	c.1201C>T/c.7018T>C	{"RYR1": {"c.1201C>T": 1, "c.7018T>C": 1}}	\N
7821591	7815081	c.14201G>A/c.14477C>T	{"RYR1": {"c.14201G>A": 1, "c.14477C>T": 1}}	\N
7821592	7815081	c.6487C>T/c.10229C>A	{"RYR1": {"c.6487C>T": 1, "c.10229C>A": 1}}	\N
7821593	7815081	c.5186T>G/c.7060G>A	{"RYR1": {"c.5186T>G": 1, "c.7060G>A": 1}}	\N
7821594	7815081	c.5440A>G/c.6488G>C	{"RYR1": {"c.5440A>G": 1, "c.6488G>C": 1}}	\N
7821595	7815081	c.1553T>C/c.7523G>A	{"RYR1": {"c.1553T>C": 1, "c.7523G>A": 1}}	\N
7821596	7815081	c.7291G>T/c.8926C>T	{"RYR1": {"c.7291G>T": 1, "c.8926C>T": 1}}	\N
7821597	7815081	c.5440A>G/c.6488G>A	{"RYR1": {"c.5440A>G": 1, "c.6488G>A": 1}}	\N
7821598	7815081	c.677T>A/c.11315G>A	{"RYR1": {"c.677T>A": 1, "c.11315G>A": 1}}	\N
7821599	7815081	c.7372C>T/c.11813G>A	{"RYR1": {"c.7372C>T": 1, "c.11813G>A": 1}}	\N
7821600	7815081	c.6304G>C/c.7291G>T	{"RYR1": {"c.6304G>C": 1, "c.7291G>T": 1}}	\N
7821601	7815081	c.9268G>A/c.14539G>C	{"RYR1": {"c.9268G>A": 1, "c.14539G>C": 1}}	\N
7821602	7815081	c.625G>A/c.7300G>A	{"RYR1": {"c.625G>A": 1, "c.7300G>A": 1}}	\N
7821603	7815081	c.1598G>A/c.12149C>A	{"RYR1": {"c.1598G>A": 1, "c.12149C>A": 1}}	\N
7821604	7815081	c.1615T>G/c.14825G>T	{"RYR1": {"c.1615T>G": 1, "c.14825G>T": 1}}	\N
7821605	7815081	c.12115A>T/c.14209C>T	{"RYR1": {"c.12115A>T": 1, "c.14209C>T": 1}}	\N
7821606	7815081	c.6838G>A/c.7528T>C	{"RYR1": {"c.6838G>A": 1, "c.7528T>C": 1}}	\N
7821607	7815081	c.1201C>T/c.10237A>T	{"RYR1": {"c.1201C>T": 1, "c.10237A>T": 1}}	\N
7821608	7815081	c.10042C>T/c.14477C>T	{"RYR1": {"c.10042C>T": 1, "c.14477C>T": 1}}	\N
7821609	7815081	c.11314C>T/c.11969G>T	{"RYR1": {"c.11314C>T": 1, "c.11969G>T": 1}}	\N
7821610	7815081	c.1201C>T/c.14680G>A	{"RYR1": {"c.1201C>T": 1, "c.14680G>A": 1}}	\N
7821611	7815081	c.51_53del/c.6617C>T	{"RYR1": {"c.6617C>T": 1, "c.51_53del": 1}}	\N
7821612	7815081	c.641C>T/c.7373G>A	{"RYR1": {"c.641C>T": 1, "c.7373G>A": 1}}	\N
7821613	7815081	c.38T>G/c.13760C>T	{"RYR1": {"c.38T>G": 1, "c.13760C>T": 1}}	\N
7821614	7815081	c.38T>G/c.12398A>G	{"RYR1": {"c.38T>G": 1, "c.12398A>G": 1}}	\N
7821615	7815081	c.7373G>T/c.14818G>A	{"RYR1": {"c.7373G>T": 1, "c.14818G>A": 1}}	\N
7821616	7815081	c.130C>T/c.652G>A	{"RYR1": {"c.130C>T": 1, "c.652G>A": 1}}	\N
7821617	7815081	c.487C>T/c.9850T>A	{"RYR1": {"c.487C>T": 1, "c.9850T>A": 1}}	\N
7821618	7815081	c.6304G>C/c.7291G>A	{"RYR1": {"c.6304G>C": 1, "c.7291G>A": 1}}	\N
7821619	7815081	c.487C>T/c.11748T>G	{"RYR1": {"c.487C>T": 1, "c.11748T>G": 1}}	\N
7821620	7815081	c.6612C>G/c.14270G>A	{"RYR1": {"c.6612C>G": 1, "c.14270G>A": 1}}	\N
7821621	7815081	c.1201C>T/c.12028G>A	{"RYR1": {"c.1201C>T": 1, "c.12028G>A": 1}}	\N
7821622	7815081	c.51_53del/c.6617C>G	{"RYR1": {"c.6617C>G": 1, "c.51_53del": 1}}	\N
7821623	7815081	c.982C>T/c.6742C>T	{"RYR1": {"c.982C>T": 1, "c.6742C>T": 1}}	\N
7821624	7815081	c.1615T>G/c.7778G>A	{"RYR1": {"c.1615T>G": 1, "c.7778G>A": 1}}	\N
7821625	7815081	c.7282G>A/c.9848G>A	{"RYR1": {"c.7282G>A": 1, "c.9848G>A": 1}}	\N
7821626	7815081	c.7522C>T/c.11748T>G	{"RYR1": {"c.7522C>T": 1, "c.11748T>G": 1}}	\N
7821627	7815081	c.1021G>A/c.3172G>A	{"RYR1": {"c.1021G>A": 1, "c.3172G>A": 1}}	\N
7821628	7815081	c.103T>C/c.14524G>A	{"RYR1": {"c.103T>C": 1, "c.14524G>A": 1}}	\N
7821629	7815081	c.7358T>C/c.7487C>T	{"RYR1": {"c.7358T>C": 1, "c.7487C>T": 1}}	\N
7821630	7815081	c.1597C>T/c.8600T>A	{"RYR1": {"c.1597C>T": 1, "c.8600T>A": 1}}	\N
7821631	7815081	c.7124G>C/c.13505A>G	{"RYR1": {"c.7124G>C": 1, "c.13505A>G": 1}}	\N
7821632	7815081	c.533A>C/c.1589G>A	{"RYR1": {"c.533A>C": 1, "c.1589G>A": 1}}	\N
7821633	7815081	c.1597C>A/c.3166G>C	{"RYR1": {"c.1597C>A": 1, "c.3166G>C": 1}}	\N
7821634	7815081	c.1615T>C/c.14449A>T	{"RYR1": {"c.1615T>C": 1, "c.14449A>T": 1}}	\N
7821635	7815081	c.7361G>A/c.9152G>A	{"RYR1": {"c.7361G>A": 1, "c.9152G>A": 1}}	\N
7821636	7815081	c.38T>G/c.12533G>T	{"RYR1": {"c.38T>G": 1, "c.12533G>T": 1}}	\N
7821637	7815081	c.7879G>C/c.12383C>T	{"RYR1": {"c.7879G>C": 1, "c.12383C>T": 1}}	\N
7821638	7815081	c.1201C>A/c.6487C>T	{"RYR1": {"c.1201C>A": 1, "c.6487C>T": 1}}	\N
7821639	7815081	c.641C>T/c.7373G>T	{"RYR1": {"c.641C>T": 1, "c.7373G>T": 1}}	\N
7821640	7815081	c.14364+1G>T/c.14539G>C	{"RYR1": {"c.14539G>C": 1, "c.14364+1G>T": 1}}	\N
7821641	7815081	c.7358T>C/c.14581C>T	{"RYR1": {"c.7358T>C": 1, "c.14581C>T": 1}}	\N
7821642	7815081	c.130C>T/c.14051T>C	{"RYR1": {"c.130C>T": 1, "c.14051T>C": 1}}	\N
7821643	7815081	c.7360C>T/c.14782A>G	{"RYR1": {"c.7360C>T": 1, "c.14782A>G": 1}}	\N
7821644	7815081	c.7522C>T/c.12115A>T	{"RYR1": {"c.7522C>T": 1, "c.12115A>T": 1}}	\N
7821645	7815081	c.8600T>A/c.14545G>A	{"RYR1": {"c.8600T>A": 1, "c.14545G>A": 1}}	\N
7821646	7815081	c.1630G>T/c.14567C>G	{"RYR1": {"c.1630G>T": 1, "c.14567C>G": 1}}	\N
7821647	7815081	c.7360C>T/c.14693T>C	{"RYR1": {"c.7360C>T": 1, "c.14693T>C": 1}}	\N
7821648	7815081	c.1209C>G/c.7879G>C	{"RYR1": {"c.1209C>G": 1, "c.7879G>C": 1}}	\N
7821649	7815081	c.7042_7044delGAG/c.7292A>T	{"RYR1": {"c.7292A>T": 1, "c.7042_7044delGAG": 1}}	\N
7821650	7815081	c.3166G>A/c.7007G>A	{"RYR1": {"c.3166G>A": 1, "c.7007G>A": 1}}	\N
7821651	7815081	c.1654C>T/c.8729C>T	{"RYR1": {"c.1654C>T": 1, "c.8729C>T": 1}}	\N
7821652	7815081	c.6488G>A/c.14524G>A	{"RYR1": {"c.6488G>A": 1, "c.14524G>A": 1}}	\N
7821653	7815081	c.1209C>G/c.7300G>A	{"RYR1": {"c.1209C>G": 1, "c.7300G>A": 1}}	\N
7821654	7815081	c.742G>A/c.3667G>A	{"RYR1": {"c.742G>A": 1, "c.3667G>A": 1}}	\N
7821655	7815081	c.212C>A/c.8026C>T	{"RYR1": {"c.212C>A": 1, "c.8026C>T": 1}}	\N
7821656	7815081	c.10237A>T/c.11315G>A	{"RYR1": {"c.10237A>T": 1, "c.11315G>A": 1}}	\N
7821657	7815081	c.1021G>A/c.1553T>C	{"RYR1": {"c.1021G>A": 1, "c.1553T>C": 1}}	\N
7821658	7815081	c.8654C>G/c.12700G>T	{"RYR1": {"c.8654C>G": 1, "c.12700G>T": 1}}	\N
7821659	7815081	c.497A>G/c.1021G>A	{"RYR1": {"c.497A>G": 1, "c.1021G>A": 1}}	\N
7821660	7815081	c.4775C>T/c.5183C>T	{"RYR1": {"c.4775C>T": 1, "c.5183C>T": 1}}	\N
7821661	7815081	c.947G>T/c.7282G>A	{"RYR1": {"c.947G>T": 1, "c.7282G>A": 1}}	\N
7821662	7815081	c.526G>A/c.14918C>T	{"RYR1": {"c.526G>A": 1, "c.14918C>T": 1}}	\N
7821663	7815081	c.130C>T/c.1475G>A	{"RYR1": {"c.130C>T": 1, "c.1475G>A": 1}}	\N
7821664	7815081	c.5341T>C/c.7372C>T	{"RYR1": {"c.5341T>C": 1, "c.7372C>T": 1}}	\N
7821665	7815081	c.6617C>G/c.11126C>T	{"RYR1": {"c.6617C>G": 1, "c.11126C>T": 1}}	\N
7821666	7815081	c.1598G>A/c.7304G>T	{"RYR1": {"c.1598G>A": 1, "c.7304G>T": 1}}	\N
7821667	7815081	c.1411C>T/c.12700G>T	{"RYR1": {"c.1411C>T": 1, "c.12700G>T": 1}}	\N
7821668	7815081	c.6488G>T/c.13702C>G	{"RYR1": {"c.6488G>T": 1, "c.13702C>G": 1}}	\N
7821669	7815081	c.12028G>A/c.14512C>G	{"RYR1": {"c.12028G>A": 1, "c.14512C>G": 1}}	\N
7821670	7815081	c.5186T>G/c.7084G>A	{"RYR1": {"c.5186T>G": 1, "c.7084G>A": 1}}	\N
7821671	7815081	c.467G>A/c.1565A>C	{"RYR1": {"c.467G>A": 1, "c.1565A>C": 1}}	\N
7821672	7815081	c.479A>G/c.533A>G	{"RYR1": {"c.479A>G": 1, "c.533A>G": 1}}	\N
7821673	7815081	c.1411C>T/c.7310C>T	{"RYR1": {"c.1411C>T": 1, "c.7310C>T": 1}}	\N
7821674	7815081	c.467G>A/c.1565A>G	{"RYR1": {"c.467G>A": 1, "c.1565A>G": 1}}	\N
7821675	7815081	c.1654C>T/c.8189A>G	{"RYR1": {"c.1654C>T": 1, "c.8189A>G": 1}}	\N
7821676	7815081	c.1598G>A/c.7304G>A	{"RYR1": {"c.1598G>A": 1, "c.7304G>A": 1}}	\N
7821677	7815081	c.14209C>T/c.14879T>A	{"RYR1": {"c.14209C>T": 1, "c.14879T>A": 1}}	\N
7821678	7815081	c.992_994dup/c.7048G>A	{"RYR1": {"c.7048G>A": 1, "c.992_994dup": 1}}	\N
7821679	7815081	c.1459C>G/c.1615T>G	{"RYR1": {"c.1459C>G": 1, "c.1615T>G": 1}}	\N
7821680	7815081	c.6617C>G/c.14524G>A	{"RYR1": {"c.6617C>G": 1, "c.14524G>A": 1}}	\N
7821681	7815081	c.9850T>A/c.14803G>A	{"RYR1": {"c.9850T>A": 1, "c.14803G>A": 1}}	\N
7821682	7815081	c.7036G>A/c.13994_13995delTCinsCT	{"RYR1": {"c.7036G>A": 1, "c.13994_13995delTCinsCT": 1}}	\N
7821683	7815081	c.6502G>A/c.14471T>C	{"RYR1": {"c.6502G>A": 1, "c.14471T>C": 1}}	\N
7821684	7815081	c.1422G>T/c.6838G>A	{"RYR1": {"c.1422G>T": 1, "c.6838G>A": 1}}	\N
7821685	7815081	c.6838G>A/c.8654C>G	{"RYR1": {"c.6838G>A": 1, "c.8654C>G": 1}}	\N
7821686	7815081	c.488G>T/c.12028G>A	{"RYR1": {"c.488G>T": 1, "c.12028G>A": 1}}	\N
7821687	7815081	c.1201C>T/c.7355G>A	{"RYR1": {"c.1201C>T": 1, "c.7355G>A": 1}}	\N
7821688	7815081	c.1201C>T/c.7355G>C	{"RYR1": {"c.1201C>T": 1, "c.7355G>C": 1}}	\N
7821689	7815081	c.8290G>A/c.14497C>T	{"RYR1": {"c.8290G>A": 1, "c.14497C>T": 1}}	\N
7821690	7815081	c.1565A>G/c.8189A>G	{"RYR1": {"c.1565A>G": 1, "c.8189A>G": 1}}	\N
7821691	7815081	c.497A>G/c.1021G>C	{"RYR1": {"c.497A>G": 1, "c.1021G>C": 1}}	\N
7821692	7815081	c.5341T>C/c.7360C>T	{"RYR1": {"c.5341T>C": 1, "c.7360C>T": 1}}	\N
7821693	7815081	c.5341T>C/c.7060G>A	{"RYR1": {"c.5341T>C": 1, "c.7060G>A": 1}}	\N
7821694	7815081	c.1459C>G/c.1615T>C	{"RYR1": {"c.1459C>G": 1, "c.1615T>C": 1}}	\N
7821695	7815081	c.7036G>A/c.11416G>A	{"RYR1": {"c.7036G>A": 1, "c.11416G>A": 1}}	\N
7821696	7815081	c.742G>C/c.3667G>A	{"RYR1": {"c.742G>C": 1, "c.3667G>A": 1}}	\N
7821697	7815081	c.6548G>A/c.14209C>T	{"RYR1": {"c.6548G>A": 1, "c.14209C>T": 1}}	\N
7821698	7815081	c.6349G>C/c.10750G>C	{"RYR1": {"c.6349G>C": 1, "c.10750G>C": 1}}	\N
7821699	7815081	c.6488G>T/c.9850T>A	{"RYR1": {"c.6488G>T": 1, "c.9850T>A": 1}}	\N
7821700	7815081	c.1021G>C/c.1553T>C	{"RYR1": {"c.1021G>C": 1, "c.1553T>C": 1}}	\N
7821701	7815081	c.982C>T/c.9356G>A	{"RYR1": {"c.982C>T": 1, "c.9356G>A": 1}}	\N
7821702	7815081	c.1589G>A/c.6743G>A	{"RYR1": {"c.1589G>A": 1, "c.6743G>A": 1}}	\N
7821703	7815081	c.7360C>T/c.8518C>T	{"RYR1": {"c.7360C>T": 1, "c.8518C>T": 1}}	\N
7821704	7815081	c.11315G>A/c.14186A>C	{"RYR1": {"c.11315G>A": 1, "c.14186A>C": 1}}	\N
7821705	7815081	c.463C>A/c.533A>C	{"RYR1": {"c.463C>A": 1, "c.533A>C": 1}}	\N
7821706	7815081	c.1615T>G/c.14449A>T	{"RYR1": {"c.1615T>G": 1, "c.14449A>T": 1}}	\N
7821707	7815081	c.11120G>T/c.11315G>A	{"RYR1": {"c.11120G>T": 1, "c.11315G>A": 1}}	\N
7821708	7815081	c.6037A>C/c.14539G>C	{"RYR1": {"c.6037A>C": 1, "c.14539G>C": 1}}	\N
7821709	7815081	c.6617C>T/c.11416G>A	{"RYR1": {"c.6617C>T": 1, "c.11416G>A": 1}}	\N
7821710	7815081	c.7523G>A/c.10891G>T	{"RYR1": {"c.7523G>A": 1, "c.10891G>T": 1}}	\N
7821711	7815081	c.3656A>C/c.14539G>C	{"RYR1": {"c.3656A>C": 1, "c.14539G>C": 1}}	\N
7821712	7815081	c.7076G>A/c.8290G>A	{"RYR1": {"c.7076G>A": 1, "c.8290G>A": 1}}	\N
7821713	7815081	c.6635T>A/c.7043A>G	{"RYR1": {"c.6635T>A": 1, "c.7043A>G": 1}}	\N
7821714	7815081	c.4775C>T/c.7090T>G	{"RYR1": {"c.4775C>T": 1, "c.7090T>G": 1}}	\N
7821715	7815081	c.479A>G/c.12700G>C	{"RYR1": {"c.479A>G": 1, "c.12700G>C": 1}}	\N
7821716	7815081	c.10556C>T/c.14209C>T	{"RYR1": {"c.10556C>T": 1, "c.14209C>T": 1}}	\N
7821717	7815081	c.12398A>G/c.14477C>T	{"RYR1": {"c.12398A>G": 1, "c.14477C>T": 1}}	\N
7821718	7815081	c.7042_7044delGAG/c.11416G>A	{"RYR1": {"c.11416G>A": 1, "c.7042_7044delGAG": 1}}	\N
7821719	7815081	c.131G>A/c.7522C>T	{"RYR1": {"c.131G>A": 1, "c.7522C>T": 1}}	\N
7821720	7815081	c.1411C>T/c.12700G>C	{"RYR1": {"c.1411C>T": 1, "c.12700G>C": 1}}	\N
7821721	7815081	c.14126C>T/c.14539G>C	{"RYR1": {"c.14126C>T": 1, "c.14539G>C": 1}}	\N
7821722	7815081	c.7771C>T/c.14512C>G	{"RYR1": {"c.7771C>T": 1, "c.14512C>G": 1}}	\N
7821723	7815081	c.7354C>T/c.14387A>G	{"RYR1": {"c.7354C>T": 1, "c.14387A>G": 1}}	\N
7821724	7815081	c.9649T>C/c.14477C>T	{"RYR1": {"c.9649T>C": 1, "c.14477C>T": 1}}	\N
7821725	7815081	c.178G>A/c.1597C>T	{"RYR1": {"c.178G>A": 1, "c.1597C>T": 1}}	\N
7821726	7815081	c.479A>G/c.12700G>T	{"RYR1": {"c.479A>G": 1, "c.12700G>T": 1}}	\N
7821727	7815081	c.7007G>A/c.14002C>T	{"RYR1": {"c.7007G>A": 1, "c.14002C>T": 1}}	\N
7821728	7815081	c.8654C>G/c.12700G>C	{"RYR1": {"c.8654C>G": 1, "c.12700G>C": 1}}	\N
7821729	7815081	c.7385C>T/c.14497C>T	{"RYR1": {"c.7385C>T": 1, "c.14497C>T": 1}}	\N
7821730	7815081	c.97A>G/c.10229C>A	{"RYR1": {"c.97A>G": 1, "c.10229C>A": 1}}	\N
7821731	7815081	c.1841G>T/c.6037A>C	{"RYR1": {"c.1841G>T": 1, "c.6037A>C": 1}}	\N
7821732	7815081	c.1202G>T/c.3166G>A	{"RYR1": {"c.1202G>T": 1, "c.3166G>A": 1}}	\N
7821733	7815081	c.4747C>T/c.5183C>T	{"RYR1": {"c.4747C>T": 1, "c.5183C>T": 1}}	\N
7821734	7815081	c.6487C>T/c.8527T>C	{"RYR1": {"c.6487C>T": 1, "c.8527T>C": 1}}	\N
7821735	7815081	c.641C>T/c.7361G>A	{"RYR1": {"c.641C>T": 1, "c.7361G>A": 1}}	\N
7821736	7815081	c.7042_7044delGAG/c.13994_13995delTCinsCT	{"RYR1": {"c.7042_7044delGAG": 1, "c.13994_13995delTCinsCT": 1}}	\N
7821737	7815081	c.742G>A/c.14051T>C	{"RYR1": {"c.742G>A": 1, "c.14051T>C": 1}}	\N
7821738	7815081	c.7063C>T/c.14817C>A	{"RYR1": {"c.7063C>T": 1, "c.14817C>A": 1}}	\N
7821739	7815081	c.1841G>T/c.14813T>C	{"RYR1": {"c.1841G>T": 1, "c.14813T>C": 1}}	\N
7821740	7815081	c.1411C>T/c.7361G>A	{"RYR1": {"c.1411C>T": 1, "c.7361G>A": 1}}	\N
7821741	7815081	c.487C>T/c.13918A>G	{"RYR1": {"c.487C>T": 1, "c.13918A>G": 1}}	\N
7821742	7815081	c.11416G>A/c.12700G>C	{"RYR1": {"c.11416G>A": 1, "c.12700G>C": 1}}	\N
7821743	7815081	c.12700G>T/c.14471T>C	{"RYR1": {"c.12700G>T": 1, "c.14471T>C": 1}}	\N
7821744	7815081	c.1589G>A/c.11086G>C	{"RYR1": {"c.1589G>A": 1, "c.11086G>C": 1}}	\N
7821745	7815081	c.6502G>A/c.10891G>T	{"RYR1": {"c.6502G>A": 1, "c.10891G>T": 1}}	\N
7821746	7815081	c.6617C>G/c.6743G>A	{"RYR1": {"c.6617C>G": 1, "c.6743G>A": 1}}	\N
7821747	7815081	c.487C>T/c.13702C>G	{"RYR1": {"c.487C>T": 1, "c.13702C>G": 1}}	\N
7821748	7815081	c.7035C>A/c.7355G>C	{"RYR1": {"c.7035C>A": 1, "c.7355G>C": 1}}	\N
7821749	7815081	c.7361G>A/c.11723A>T	{"RYR1": {"c.7361G>A": 1, "c.11723A>T": 1}}	\N
7821750	7815081	c.7035C>A/c.7355G>A	{"RYR1": {"c.7035C>A": 1, "c.7355G>A": 1}}	\N
7821751	7815081	c.11416G>A/c.12700G>T	{"RYR1": {"c.11416G>A": 1, "c.12700G>T": 1}}	\N
7821752	7815081	c.947G>T/c.14545G>A	{"RYR1": {"c.947G>T": 1, "c.14545G>A": 1}}	\N
7821753	7815081	c.7089C>G/c.14210G>A	{"RYR1": {"c.7089C>G": 1, "c.14210G>A": 1}}	\N
7821754	7815081	c.455C>A/c.1654C>T	{"RYR1": {"c.455C>A": 1, "c.1654C>T": 1}}	\N
7821755	7815081	c.7112A>G/c.7358T>C	{"RYR1": {"c.7112A>G": 1, "c.7358T>C": 1}}	\N
7821756	7815081	c.14449A>T/c.14918C>T	{"RYR1": {"c.14449A>T": 1, "c.14918C>T": 1}}	\N
7821757	7815081	c.1589G>A/c.7777C>G	{"RYR1": {"c.1589G>A": 1, "c.7777C>G": 1}}	\N
7821758	7815081	c.5441T>A/c.7291G>A	{"RYR1": {"c.5441T>A": 1, "c.7291G>A": 1}}	\N
7821759	7815081	c.3127C>T/c.14918C>T	{"RYR1": {"c.3127C>T": 1, "c.14918C>T": 1}}	\N
7821760	7815081	c.6617C>T/c.8198G>A	{"RYR1": {"c.6617C>T": 1, "c.8198G>A": 1}}	\N
7821761	7815081	c.5033A>G/c.14477C>T	{"RYR1": {"c.5033A>G": 1, "c.14477C>T": 1}}	\N
7821762	7815081	c.5441T>A/c.7035C>A	{"RYR1": {"c.5441T>A": 1, "c.7035C>A": 1}}	\N
7821763	7815081	c.7310C>T/c.11132C>T	{"RYR1": {"c.7310C>T": 1, "c.11132C>T": 1}}	\N
7821764	7815081	c.1411C>T/c.7373G>A	{"RYR1": {"c.1411C>T": 1, "c.7373G>A": 1}}	\N
7821765	7815081	c.2924G>A/c.3166G>C	{"RYR1": {"c.2924G>A": 1, "c.3166G>C": 1}}	\N
7821766	7815081	c.7354C>T/c.15059G>C	{"RYR1": {"c.7354C>T": 1, "c.15059G>C": 1}}	\N
7821767	7815081	c.6488G>C/c.14968A>G	{"RYR1": {"c.6488G>C": 1, "c.14968A>G": 1}}	\N
7821768	7815081	c.7075C>T/c.12149C>A	{"RYR1": {"c.7075C>T": 1, "c.12149C>A": 1}}	\N
7821769	7815081	c.487C>T/c.1201C>A	{"RYR1": {"c.487C>T": 1, "c.1201C>A": 1}}	\N
7821770	7815081	c.487C>T/c.1201C>G	{"RYR1": {"c.487C>T": 1, "c.1201C>G": 1}}	\N
7821771	7815081	c.487C>T/c.6548G>A	{"RYR1": {"c.487C>T": 1, "c.6548G>A": 1}}	\N
7821772	7815081	c.982C>T/c.1598G>A	{"RYR1": {"c.982C>T": 1, "c.1598G>A": 1}}	\N
7821773	7815081	c.38T>G/c.3166G>A	{"RYR1": {"c.38T>G": 1, "c.3166G>A": 1}}	\N
7821774	7815081	c.6349G>C/c.14818G>A	{"RYR1": {"c.6349G>C": 1, "c.14818G>A": 1}}	\N
7821775	7815081	c.6617C>T/c.7292A>T	{"RYR1": {"c.6617C>T": 1, "c.7292A>T": 1}}	\N
7821776	7815081	c.1209C>G/c.14209C>T	{"RYR1": {"c.1209C>G": 1, "c.14209C>T": 1}}	\N
7821777	7815081	c.7354C>T/c.14693T>C	{"RYR1": {"c.7354C>T": 1, "c.14693T>C": 1}}	\N
7821778	7815081	c.5441T>A/c.7291G>T	{"RYR1": {"c.5441T>A": 1, "c.7291G>T": 1}}	\N
7821779	7815081	c.1615T>C/c.7307G>A	{"RYR1": {"c.1615T>C": 1, "c.7307G>A": 1}}	\N
7821780	7815081	c.7007G>A/c.15060G>C	{"RYR1": {"c.7007G>A": 1, "c.15060G>C": 1}}	\N
7821781	7815081	c.493G>A/c.14512C>G	{"RYR1": {"c.493G>A": 1, "c.14512C>G": 1}}	\N
7821782	7815081	c.982C>T/c.12115A>T	{"RYR1": {"c.982C>T": 1, "c.12115A>T": 1}}	\N
7821783	7815081	c.6742C>T/c.7358T>C	{"RYR1": {"c.6742C>T": 1, "c.7358T>C": 1}}	\N
7821784	7815081	c.1201C>G/c.14918C>T	{"RYR1": {"c.1201C>G": 1, "c.14918C>T": 1}}	\N
7821785	7815081	c.7018T>C/c.7291G>A	{"RYR1": {"c.7018T>C": 1, "c.7291G>A": 1}}	\N
7821786	7815081	c.1615T>C/c.3667G>A	{"RYR1": {"c.1615T>C": 1, "c.3667G>A": 1}}	\N
7821787	7815081	c.1411C>T/c.7373G>T	{"RYR1": {"c.1411C>T": 1, "c.7373G>T": 1}}	\N
7821788	7815081	c.1201C>G/c.7522C>T	{"RYR1": {"c.1201C>G": 1, "c.7522C>T": 1}}	\N
7821789	7815081	c.8527T>C/c.11315G>A	{"RYR1": {"c.8527T>C": 1, "c.11315G>A": 1}}	\N
7821790	7815081	c.487C>T/c.14458G>T	{"RYR1": {"c.487C>T": 1, "c.14458G>T": 1}}	\N
7821791	7815081	c.7771C>G/c.14512C>G	{"RYR1": {"c.7771C>G": 1, "c.14512C>G": 1}}	\N
7821792	7815081	c.9310G>A/c.14509C>G	{"RYR1": {"c.9310G>A": 1, "c.14509C>G": 1}}	\N
7821793	7815081	c.1834G>C/c.9310G>A	{"RYR1": {"c.1834G>C": 1, "c.9310G>A": 1}}	\N
7821794	7815081	c.1589G>A/c.6478G>A	{"RYR1": {"c.1589G>A": 1, "c.6478G>A": 1}}	\N
7821795	7815081	c.14051T>C/c.14497C>T	{"RYR1": {"c.14051T>C": 1, "c.14497C>T": 1}}	\N
7821796	7815081	c.5024T>C/c.14803G>A	{"RYR1": {"c.5024T>C": 1, "c.14803G>A": 1}}	\N
7821797	7815081	c.6617C>T/c.7075C>T	{"RYR1": {"c.6617C>T": 1, "c.7075C>T": 1}}	\N
7821798	7815081	c.9310G>A/c.9649T>C	{"RYR1": {"c.9310G>A": 1, "c.9649T>C": 1}}	\N
7821799	7815081	c.12848A>T/c.14918C>T	{"RYR1": {"c.12848A>T": 1, "c.14918C>T": 1}}	\N
7821800	7815081	c.1840C>T/c.3095G>A	{"RYR1": {"c.1840C>T": 1, "c.3095G>A": 1}}	\N
7821801	7815081	c.487C>T/c.14458G>A	{"RYR1": {"c.487C>T": 1, "c.14458G>A": 1}}	\N
7821802	7815081	c.11314C>T/c.14539G>C	{"RYR1": {"c.11314C>T": 1, "c.14539G>C": 1}}	\N
7821803	7815081	c.6671G>A/c.7124G>C	{"RYR1": {"c.6671G>A": 1, "c.7124G>C": 1}}	\N
7821804	7815081	c.1589G>A/c.14524G>A	{"RYR1": {"c.1589G>A": 1, "c.14524G>A": 1}}	\N
7821805	7815081	c.14680G>A/c.14803G>A	{"RYR1": {"c.14680G>A": 1, "c.14803G>A": 1}}	\N
7821806	7815081	c.8290G>A/c.11969G>T	{"RYR1": {"c.8290G>A": 1, "c.11969G>T": 1}}	\N
7821807	7815081	c.947G>T/c.7124G>C	{"RYR1": {"c.947G>T": 1, "c.7124G>C": 1}}	\N
7821808	7815081	c.7373G>A/c.12028G>A	{"RYR1": {"c.7373G>A": 1, "c.12028G>A": 1}}	\N
7821809	7815081	c.7018T>C/c.7291G>T	{"RYR1": {"c.7018T>C": 1, "c.7291G>T": 1}}	\N
7821810	7815081	c.7291G>A/c.14680G>A	{"RYR1": {"c.7291G>A": 1, "c.14680G>A": 1}}	\N
7821811	7815081	c.7007G>A/c.15059G>C	{"RYR1": {"c.7007G>A": 1, "c.15059G>C": 1}}	\N
7821812	7815081	c.1841G>T/c.7760A>G	{"RYR1": {"c.1841G>T": 1, "c.7760A>G": 1}}	\N
7821813	7815081	c.3166G>C/c.14186A>C	{"RYR1": {"c.3166G>C": 1, "c.14186A>C": 1}}	\N
7821814	7815081	c.1202G>T/c.12121C>T	{"RYR1": {"c.1202G>T": 1, "c.12121C>T": 1}}	\N
7821815	7815081	c.1597C>T/c.7089C>G	{"RYR1": {"c.1597C>T": 1, "c.7089C>G": 1}}	\N
7821816	7815081	c.11947C>T/c.14477C>T	{"RYR1": {"c.11947C>T": 1, "c.14477C>T": 1}}	\N
7821817	7815081	c.7076G>A/c.9635A>G	{"RYR1": {"c.7076G>A": 1, "c.9635A>G": 1}}	\N
7821818	7815081	c.190T>C/c.7358T>C	{"RYR1": {"c.190T>C": 1, "c.7358T>C": 1}}	\N
7821819	7815081	c.130C>T/c.9797T>C	{"RYR1": {"c.130C>T": 1, "c.9797T>C": 1}}	\N
7821820	7815081	c.488G>T/c.2996G>A	{"RYR1": {"c.488G>T": 1, "c.2996G>A": 1}}	\N
7821821	7815081	c.463C>A/c.2996G>A	{"RYR1": {"c.463C>A": 1, "c.2996G>A": 1}}	\N
7821822	7815081	c.1024G>A/c.6617C>T	{"RYR1": {"c.1024G>A": 1, "c.6617C>T": 1}}	\N
7821823	7815081	c.6628G>T/c.11086G>C	{"RYR1": {"c.6628G>T": 1, "c.11086G>C": 1}}	\N
7821824	7815081	c.1565A>C/c.7099G>A	{"RYR1": {"c.1565A>C": 1, "c.7099G>A": 1}}	\N
7821825	7815081	c.4763C>T/c.7042_7044delGAG	{"RYR1": {"c.4763C>T": 1, "c.7042_7044delGAG": 1}}	\N
7821826	7815081	c.1589G>A/c.14201G>A	{"RYR1": {"c.1589G>A": 1, "c.14201G>A": 1}}	\N
7821827	7815081	c.463C>A/c.7879G>A	{"RYR1": {"c.463C>A": 1, "c.7879G>A": 1}}	\N
7821828	7815081	c.7035C>A/c.8654C>G	{"RYR1": {"c.7035C>A": 1, "c.8654C>G": 1}}	\N
7821829	7815081	c.7085A>G/c.7300G>A	{"RYR1": {"c.7085A>G": 1, "c.7300G>A": 1}}	\N
7821830	7815081	c.7358T>C/c.11958C>G	{"RYR1": {"c.7358T>C": 1, "c.11958C>G": 1}}	\N
7821831	7815081	c.1024G>A/c.6617C>G	{"RYR1": {"c.1024G>A": 1, "c.6617C>G": 1}}	\N
7821832	7815081	c.7304G>T/c.14422_14423delinsAA	{"RYR1": {"c.7304G>T": 1, "c.14422_14423delinsAA": 1}}	\N
7821833	7815081	c.529C>T/c.6377G>A	{"RYR1": {"c.529C>T": 1, "c.6377G>A": 1}}	\N
7821834	7815081	c.6488G>T/c.11126C>T	{"RYR1": {"c.6488G>T": 1, "c.11126C>T": 1}}	\N
7821835	7815081	c.7007G>A/c.7787C>T	{"RYR1": {"c.7007G>A": 1, "c.7787C>T": 1}}	\N
7821836	7815081	c.7007G>A/c.9635A>G	{"RYR1": {"c.7007G>A": 1, "c.9635A>G": 1}}	\N
7821837	7815081	c.529C>T/c.8638G>A	{"RYR1": {"c.529C>T": 1, "c.8638G>A": 1}}	\N
7821838	7815081	c.6628G>T/c.14693T>C	{"RYR1": {"c.6628G>T": 1, "c.14693T>C": 1}}	\N
7821839	7815081	c.7063C>T/c.7385C>T	{"RYR1": {"c.7063C>T": 1, "c.7385C>T": 1}}	\N
7821840	7815081	c.7076G>A/c.7097C>G	{"RYR1": {"c.7076G>A": 1, "c.7097C>G": 1}}	\N
7821841	7815081	c.3166G>A/c.6487C>T	{"RYR1": {"c.3166G>A": 1, "c.6487C>T": 1}}	\N
7821842	7815081	c.119G>C/c.1630G>T	{"RYR1": {"c.119G>C": 1, "c.1630G>T": 1}}	\N
7821843	7815081	c.103T>C/c.11132C>T	{"RYR1": {"c.103T>C": 1, "c.11132C>T": 1}}	\N
7821844	7815081	c.6710G>A/c.11708G>A	{"RYR1": {"c.6710G>A": 1, "c.11708G>A": 1}}	\N
7821845	7815081	c.982C>T/c.12689T>G	{"RYR1": {"c.982C>T": 1, "c.12689T>G": 1}}	\N
7821846	7815081	c.7522C>T/c.7787C>T	{"RYR1": {"c.7522C>T": 1, "c.7787C>T": 1}}	\N
7821847	7815081	c.680A>T/c.1021G>A	{"RYR1": {"c.680A>T": 1, "c.1021G>A": 1}}	\N
7821848	7815081	c.14210G>A/c.14582G>A	{"RYR1": {"c.14210G>A": 1, "c.14582G>A": 1}}	\N
7821849	7815081	c.1615T>G/c.7307G>A	{"RYR1": {"c.1615T>G": 1, "c.7307G>A": 1}}	\N
7821850	7815081	c.7304G>A/c.7355G>C	{"RYR1": {"c.7304G>A": 1, "c.7355G>C": 1}}	\N
7821851	7815081	c.3667G>A/c.9310G>A	{"RYR1": {"c.3667G>A": 1, "c.9310G>A": 1}}	\N
7821852	7815081	c.6612C>G/c.12115A>T	{"RYR1": {"c.6612C>G": 1, "c.12115A>T": 1}}	\N
7821853	7815081	c.7304G>A/c.7355G>A	{"RYR1": {"c.7304G>A": 1, "c.7355G>A": 1}}	\N
7821854	7815081	c.7042_7044delGAG/c.14825G>T	{"RYR1": {"c.14825G>T": 1, "c.7042_7044delGAG": 1}}	\N
7821855	7815081	c.742G>C/c.14051T>C	{"RYR1": {"c.742G>C": 1, "c.14051T>C": 1}}	\N
7821856	7815081	c.3166G>A/c.14209C>T	{"RYR1": {"c.3166G>A": 1, "c.14209C>T": 1}}	\N
7821857	7815081	c.1209C>G/c.1597C>T	{"RYR1": {"c.1209C>G": 1, "c.1597C>T": 1}}	\N
7821858	7815081	c.6488G>T/c.7778G>A	{"RYR1": {"c.6488G>T": 1, "c.7778G>A": 1}}	\N
7821859	7815081	c.1202G>T/c.14567C>G	{"RYR1": {"c.1202G>T": 1, "c.14567C>G": 1}}	\N
7821860	7815081	c.7354C>T/c.9635A>G	{"RYR1": {"c.7354C>T": 1, "c.9635A>G": 1}}	\N
7821861	7815081	c.1597C>T/c.11416G>A	{"RYR1": {"c.1597C>T": 1, "c.11416G>A": 1}}	\N
7821862	7815081	c.488G>A/c.7361G>A	{"RYR1": {"c.488G>A": 1, "c.7361G>A": 1}}	\N
7821863	7815081	c.1840C>T/c.8290G>A	{"RYR1": {"c.1840C>T": 1, "c.8290G>A": 1}}	\N
7821864	7815081	c.497A>G/c.533A>G	{"RYR1": {"c.497A>G": 1, "c.533A>G": 1}}	\N
7821865	7815081	c.190T>C/c.6502G>A	{"RYR1": {"c.190T>C": 1, "c.6502G>A": 1}}	\N
7821866	7815081	c.2924G>A/c.7291G>T	{"RYR1": {"c.2924G>A": 1, "c.7291G>T": 1}}	\N
7821867	7815081	c.1615T>G/c.3667G>A	{"RYR1": {"c.1615T>G": 1, "c.3667G>A": 1}}	\N
7821868	7815081	c.488G>T/c.11314C>T	{"RYR1": {"c.488G>T": 1, "c.11314C>T": 1}}	\N
7821869	7815081	c.680A>T/c.1021G>C	{"RYR1": {"c.680A>T": 1, "c.1021G>C": 1}}	\N
7821870	7815081	c.1598G>A/c.6628G>T	{"RYR1": {"c.1598G>A": 1, "c.6628G>T": 1}}	\N
7821871	7815081	c.7035C>A/c.7112A>G	{"RYR1": {"c.7035C>A": 1, "c.7112A>G": 1}}	\N
7821872	7815081	c.7018T>C/c.7035C>A	{"RYR1": {"c.7018T>C": 1, "c.7035C>A": 1}}	\N
7821873	7815081	c.7291G>T/c.7787C>T	{"RYR1": {"c.7291G>T": 1, "c.7787C>T": 1}}	\N
7821874	7815081	c.6617C>G/c.7777C>G	{"RYR1": {"c.6617C>G": 1, "c.7777C>G": 1}}	\N
7821875	7815081	c.1100G>T/c.14803G>A	{"RYR1": {"c.1100G>T": 1, "c.14803G>A": 1}}	\N
7821876	7815081	c.7310C>T/c.8729C>T	{"RYR1": {"c.7310C>T": 1, "c.8729C>T": 1}}	\N
7821877	7815081	c.2924G>A/c.7291G>A	{"RYR1": {"c.2924G>A": 1, "c.7291G>A": 1}}	\N
7821878	7815081	c.6349G>C/c.13672C>T	{"RYR1": {"c.6349G>C": 1, "c.13672C>T": 1}}	\N
7821879	7815081	c.7282G>A/c.13990T>C	{"RYR1": {"c.7282G>A": 1, "c.13990T>C": 1}}	\N
7821880	7815081	c.9310G>A/c.10229C>A	{"RYR1": {"c.9310G>A": 1, "c.10229C>A": 1}}	\N
7821881	7815081	c.463C>A/c.3127C>T	{"RYR1": {"c.463C>A": 1, "c.3127C>T": 1}}	\N
7821882	7815081	c.6502G>A/c.14186A>C	{"RYR1": {"c.6502G>A": 1, "c.14186A>C": 1}}	\N
7821883	7815081	c.1654C>T/c.12121C>T	{"RYR1": {"c.1654C>T": 1, "c.12121C>T": 1}}	\N
7821884	7815081	c.1615T>C/c.10556C>T	{"RYR1": {"c.1615T>C": 1, "c.10556C>T": 1}}	\N
7821885	7815081	c.5033A>G/c.9310G>A	{"RYR1": {"c.5033A>G": 1, "c.9310G>A": 1}}	\N
7821886	7815081	c.1201C>T/c.7099G>A	{"RYR1": {"c.1201C>T": 1, "c.7099G>A": 1}}	\N
7821887	7815081	c.1460T>C/c.14918C>T	{"RYR1": {"c.1460T>C": 1, "c.14918C>T": 1}}	\N
7821888	7815081	c.5183C>T/c.6544A>T	{"RYR1": {"c.5183C>T": 1, "c.6544A>T": 1}}	\N
7821889	7815081	c.6671G>A/c.14545G>A	{"RYR1": {"c.6671G>A": 1, "c.14545G>A": 1}}	\N
7821890	7815081	c.13673G>A/c.14918C>T	{"RYR1": {"c.13673G>A": 1, "c.14918C>T": 1}}	\N
7821891	7815081	c.9310G>A/c.14558C>T	{"RYR1": {"c.9310G>A": 1, "c.14558C>T": 1}}	\N
7821892	7815081	c.7291G>A/c.14424C>A	{"RYR1": {"c.7291G>A": 1, "c.14424C>A": 1}}	\N
7821893	7815081	c.11126C>T/c.14497C>T	{"RYR1": {"c.11126C>T": 1, "c.14497C>T": 1}}	\N
7821894	7815081	c.14497C>T/c.14680G>A	{"RYR1": {"c.14497C>T": 1, "c.14680G>A": 1}}	\N
7821895	7815081	c.6488G>A/c.14968A>G	{"RYR1": {"c.6488G>A": 1, "c.14968A>G": 1}}	\N
7821896	7815081	c.7304G>T/c.7528T>C	{"RYR1": {"c.7304G>T": 1, "c.7528T>C": 1}}	\N
7821897	7815081	c.97A>G/c.9758T>C	{"RYR1": {"c.97A>G": 1, "c.9758T>C": 1}}	\N
7821898	7815081	c.1589G>A/c.8198G>A	{"RYR1": {"c.1589G>A": 1, "c.8198G>A": 1}}	\N
7821899	7815081	c.9758T>C/c.12149C>A	{"RYR1": {"c.9758T>C": 1, "c.12149C>A": 1}}	\N
7821900	7815081	c.1597C>A/c.14210G>A	{"RYR1": {"c.1597C>A": 1, "c.14210G>A": 1}}	\N
7821901	7815081	c.7771C>G/c.14803G>A	{"RYR1": {"c.7771C>G": 1, "c.14803G>A": 1}}	\N
7821902	7815081	c.680A>T/c.7043A>G	{"RYR1": {"c.680A>T": 1, "c.7043A>G": 1}}	\N
7821903	7815081	c.14471T>C/c.14627A>G	{"RYR1": {"c.14471T>C": 1, "c.14627A>G": 1}}	\N
7821904	7815081	c.7360C>T/c.9850T>A	{"RYR1": {"c.7360C>T": 1, "c.9850T>A": 1}}	\N
7821905	7815081	c.1597C>T/c.3166G>A	{"RYR1": {"c.1597C>T": 1, "c.3166G>A": 1}}	\N
7821906	7815081	c.103T>C/c.11086G>C	{"RYR1": {"c.103T>C": 1, "c.11086G>C": 1}}	\N
7821907	7815081	c.6617C>T/c.8518C>T	{"RYR1": {"c.6617C>T": 1, "c.8518C>T": 1}}	\N
7821908	7815081	c.7035C>A/c.7487C>T	{"RYR1": {"c.7035C>A": 1, "c.7487C>T": 1}}	\N
7821909	7815081	c.7358T>C/c.8527T>C	{"RYR1": {"c.7358T>C": 1, "c.8527T>C": 1}}	\N
7821910	7815081	c.103T>C/c.7777C>G	{"RYR1": {"c.103T>C": 1, "c.7777C>G": 1}}	\N
7821911	7815081	c.7043A>G/c.12398A>G	{"RYR1": {"c.7043A>G": 1, "c.12398A>G": 1}}	\N
7821912	7815081	c.5440A>G/c.14497C>T	{"RYR1": {"c.5440A>G": 1, "c.14497C>T": 1}}	\N
7821913	7815081	c.7304G>T/c.10237A>T	{"RYR1": {"c.7304G>T": 1, "c.10237A>T": 1}}	\N
7821914	7815081	c.7787C>T/c.14210G>A	{"RYR1": {"c.7787C>T": 1, "c.14210G>A": 1}}	\N
7821915	7815081	c.3172G>A/c.14209C>T	{"RYR1": {"c.3172G>A": 1, "c.14209C>T": 1}}	\N
7821916	7815081	c.212C>A/c.14477C>T	{"RYR1": {"c.212C>A": 1, "c.14477C>T": 1}}	\N
7821917	7815081	c.742G>A/c.5132A>G	{"RYR1": {"c.742G>A": 1, "c.5132A>G": 1}}	\N
7821918	7815081	c.2122G>A/c.14512C>G	{"RYR1": {"c.2122G>A": 1, "c.14512C>G": 1}}	\N
7821919	7815081	c.7300G>A/c.14471T>C	{"RYR1": {"c.7300G>A": 1, "c.14471T>C": 1}}	\N
7821920	7815081	c.6388G>A/c.7007G>A	{"RYR1": {"c.6388G>A": 1, "c.7007G>A": 1}}	\N
7821921	7815081	c.1565A>C/c.7879G>A	{"RYR1": {"c.1565A>C": 1, "c.7879G>A": 1}}	\N
7821922	7815081	c.1021G>A/c.5033A>G	{"RYR1": {"c.1021G>A": 1, "c.5033A>G": 1}}	\N
7821923	7815081	c.6487C>T/c.7112A>G	{"RYR1": {"c.6487C>T": 1, "c.7112A>G": 1}}	\N
7821924	7815081	c.7042_7044delGAG/c.7778G>A	{"RYR1": {"c.7778G>A": 1, "c.7042_7044delGAG": 1}}	\N
7821925	7815081	c.9356G>A/c.14512C>G	{"RYR1": {"c.9356G>A": 1, "c.14512C>G": 1}}	\N
7821926	7815081	c.1615T>C/c.12689T>G	{"RYR1": {"c.1615T>C": 1, "c.12689T>G": 1}}	\N
7821927	7815081	c.38T>G/c.1422G>T	{"RYR1": {"c.38T>G": 1, "c.1422G>T": 1}}	\N
7821928	7815081	c.6304G>C/c.7035C>A	{"RYR1": {"c.6304G>C": 1, "c.7035C>A": 1}}	\N
7821929	7815081	c.178G>T/c.1597C>T	{"RYR1": {"c.178G>T": 1, "c.1597C>T": 1}}	\N
7821930	7815081	c.1460T>C/c.7522C>T	{"RYR1": {"c.1460T>C": 1, "c.7522C>T": 1}}	\N
7821931	7815081	c.742G>A/c.14879T>A	{"RYR1": {"c.742G>A": 1, "c.14879T>A": 1}}	\N
7821932	7815081	c.1202G>T/c.13994_13995delTCinsCT	{"RYR1": {"c.1202G>T": 1, "c.13994_13995delTCinsCT": 1}}	\N
7821933	7815081	c.982C>T/c.9152G>A	{"RYR1": {"c.982C>T": 1, "c.9152G>A": 1}}	\N
7821934	7815081	c.1475G>A/c.8026C>T	{"RYR1": {"c.1475G>A": 1, "c.8026C>T": 1}}	\N
7821935	7815081	c.9848G>A/c.14512C>G	{"RYR1": {"c.9848G>A": 1, "c.14512C>G": 1}}	\N
7821936	7815081	c.11708G>A/c.12398A>G	{"RYR1": {"c.11708G>A": 1, "c.12398A>G": 1}}	\N
7821937	7815081	c.6617C>T/c.14524G>A	{"RYR1": {"c.6617C>T": 1, "c.14524G>A": 1}}	\N
7821938	7815081	c.5440A>G/c.14209C>T	{"RYR1": {"c.5440A>G": 1, "c.14209C>T": 1}}	\N
7821939	7815081	c.7354C>T/c.13918A>G	{"RYR1": {"c.7354C>T": 1, "c.13918A>G": 1}}	\N
7821940	7815081	c.7304G>A/c.12028G>A	{"RYR1": {"c.7304G>A": 1, "c.12028G>A": 1}}	\N
7821941	7815081	c.533A>G/c.7097C>G	{"RYR1": {"c.533A>G": 1, "c.7097C>G": 1}}	\N
7821942	7815081	c.7300G>A/c.12355A>T	{"RYR1": {"c.7300G>A": 1, "c.12355A>T": 1}}	\N
7821943	7815081	c.7358T>C/c.13994_13995delTCinsCT	{"RYR1": {"c.7358T>C": 1, "c.13994_13995delTCinsCT": 1}}	\N
7821944	7815081	c.1840C>T/c.11958C>G	{"RYR1": {"c.1840C>T": 1, "c.11958C>G": 1}}	\N
7821945	7815081	c.103T>C/c.6478G>A	{"RYR1": {"c.103T>C": 1, "c.6478G>A": 1}}	\N
7821946	7815081	c.7090T>G/c.7771C>G	{"RYR1": {"c.7090T>G": 1, "c.7771C>G": 1}}	\N
7821947	7815081	c.6617C>G/c.11416G>A	{"RYR1": {"c.6617C>G": 1, "c.11416G>A": 1}}	\N
7821948	7815081	c.7075C>T/c.11969G>T	{"RYR1": {"c.7075C>T": 1, "c.11969G>T": 1}}	\N
7821949	7815081	c.7043A>G/c.7385C>T	{"RYR1": {"c.7043A>G": 1, "c.7385C>T": 1}}	\N
7821950	7815081	c.12149C>A/c.14567C>G	{"RYR1": {"c.12149C>A": 1, "c.14567C>G": 1}}	\N
7821951	7815081	c.152C>A/c.7522C>T	{"RYR1": {"c.152C>A": 1, "c.7522C>T": 1}}	\N
7821952	7815081	c.1597C>A/c.7354C>T	{"RYR1": {"c.1597C>A": 1, "c.7354C>T": 1}}	\N
7821953	7815081	c.1565A>G/c.6037A>C	{"RYR1": {"c.1565A>G": 1, "c.6037A>C": 1}}	\N
7821954	7815081	c.7035C>A/c.12028G>A	{"RYR1": {"c.7035C>A": 1, "c.12028G>A": 1}}	\N
7821955	7815081	c.7090T>G/c.7771C>T	{"RYR1": {"c.7090T>G": 1, "c.7771C>T": 1}}	\N
7821956	7815081	c.11132C>T/c.11969G>T	{"RYR1": {"c.11132C>T": 1, "c.11969G>T": 1}}	\N
7821957	7815081	c.1209C>G/c.7373G>T	{"RYR1": {"c.1209C>G": 1, "c.7373G>T": 1}}	\N
7821958	7815081	c.9850T>A/c.14477C>T	{"RYR1": {"c.9850T>A": 1, "c.14477C>T": 1}}	\N
7821959	7815081	c.487C>T/c.14693T>C	{"RYR1": {"c.487C>T": 1, "c.14693T>C": 1}}	\N
7821960	7815081	c.742G>C/c.5132A>G	{"RYR1": {"c.742G>C": 1, "c.5132A>G": 1}}	\N
7821961	7815081	c.7372C>T/c.9635A>G	{"RYR1": {"c.7372C>T": 1, "c.9635A>G": 1}}	\N
7821962	7815081	c.9310G>A/c.13673G>A	{"RYR1": {"c.9310G>A": 1, "c.13673G>A": 1}}	\N
7821963	7815081	c.1021G>C/c.5033A>G	{"RYR1": {"c.1021G>C": 1, "c.5033A>G": 1}}	\N
7821964	7815081	c.488G>A/c.7373G>A	{"RYR1": {"c.488G>A": 1, "c.7373G>A": 1}}	\N
7821965	7815081	c.1209C>G/c.7373G>A	{"RYR1": {"c.1209C>G": 1, "c.7373G>A": 1}}	\N
7821966	7815081	c.7036G>A/c.14582G>A	{"RYR1": {"c.7036G>A": 1, "c.14582G>A": 1}}	\N
7821967	7815081	c.7042_7044delGAG/c.11126C>T	{"RYR1": {"c.11126C>T": 1, "c.7042_7044delGAG": 1}}	\N
7821968	7815081	c.7090T>G/c.14817C>A	{"RYR1": {"c.7090T>G": 1, "c.14817C>A": 1}}	\N
7821969	7815081	c.1589G>A/c.11132C>T	{"RYR1": {"c.1589G>A": 1, "c.11132C>T": 1}}	\N
7821970	7815081	c.1202G>T/c.8189A>G	{"RYR1": {"c.1202G>T": 1, "c.8189A>G": 1}}	\N
7821971	7815081	c.152C>A/c.14918C>T	{"RYR1": {"c.152C>A": 1, "c.14918C>T": 1}}	\N
7821972	7815081	c.9797T>C/c.14803G>A	{"RYR1": {"c.9797T>C": 1, "c.14803G>A": 1}}	\N
7821973	7815081	c.488G>A/c.7373G>T	{"RYR1": {"c.488G>A": 1, "c.7373G>T": 1}}	\N
7821974	7815081	c.7292A>T/c.7310C>T	{"RYR1": {"c.7292A>T": 1, "c.7310C>T": 1}}	\N
7821975	7815081	c.6617C>T/c.7777C>G	{"RYR1": {"c.6617C>T": 1, "c.7777C>G": 1}}	\N
7821976	7815081	c.1202G>T/c.12398A>G	{"RYR1": {"c.1202G>T": 1, "c.12398A>G": 1}}	\N
7821977	7815081	c.992_994dup/c.14803G>A	{"RYR1": {"c.14803G>A": 1, "c.992_994dup": 1}}	\N
7821978	7815081	c.9848G>A/c.14803G>A	{"RYR1": {"c.9848G>A": 1, "c.14803G>A": 1}}	\N
7821979	7815081	c.533A>C/c.6349G>C	{"RYR1": {"c.533A>C": 1, "c.6349G>C": 1}}	\N
7821980	7815081	c.6838G>A/c.14449A>T	{"RYR1": {"c.6838G>A": 1, "c.14449A>T": 1}}	\N
7821981	7815081	c.742G>A/c.10252A>G	{"RYR1": {"c.742G>A": 1, "c.10252A>G": 1}}	\N
7821982	7815081	c.487C>T/c.3418C>T	{"RYR1": {"c.487C>T": 1, "c.3418C>T": 1}}	\N
7821983	7815081	c.529C>T/c.3656A>C	{"RYR1": {"c.529C>T": 1, "c.3656A>C": 1}}	\N
7821984	7815081	c.7090T>G/c.7385C>T	{"RYR1": {"c.7090T>G": 1, "c.7385C>T": 1}}	\N
7821985	7815081	c.3166G>C/c.7032G>C	{"RYR1": {"c.3166G>C": 1, "c.7032G>C": 1}}	\N
7821986	7815081	c.4747C>T/c.9310G>A	{"RYR1": {"c.4747C>T": 1, "c.9310G>A": 1}}	\N
7821987	7815081	c.7097C>G/c.7310C>T	{"RYR1": {"c.7097C>G": 1, "c.7310C>T": 1}}	\N
7821988	7815081	c.7036G>A/c.11126C>T	{"RYR1": {"c.7036G>A": 1, "c.11126C>T": 1}}	\N
7821989	7815081	c.488G>A/c.7084G>A	{"RYR1": {"c.488G>A": 1, "c.7084G>A": 1}}	\N
7821990	7815081	c.4747C>T/c.7123G>A	{"RYR1": {"c.4747C>T": 1, "c.7123G>A": 1}}	\N
7821991	7815081	c.3656A>C/c.11315G>A	{"RYR1": {"c.3656A>C": 1, "c.11315G>A": 1}}	\N
7821992	7815081	c.51_53del/c.14210G>A	{"RYR1": {"c.14210G>A": 1, "c.51_53del": 1}}	\N
7821993	7815081	c.529C>T/c.992_994dup	{"RYR1": {"c.529C>T": 1, "c.992_994dup": 1}}	\N
7821994	7815081	c.6487C>T/c.8054C>T	{"RYR1": {"c.6487C>T": 1, "c.8054C>T": 1}}	\N
7821995	7815081	c.7307G>A/c.9310G>A	{"RYR1": {"c.7307G>A": 1, "c.9310G>A": 1}}	\N
7821996	7815081	c.455C>A/c.6349G>C	{"RYR1": {"c.455C>A": 1, "c.6349G>C": 1}}	\N
7821997	7815081	c.1615T>G/c.12689T>G	{"RYR1": {"c.1615T>G": 1, "c.12689T>G": 1}}	\N
7821998	7815081	c.2050G>C/c.6502G>A	{"RYR1": {"c.2050G>C": 1, "c.6502G>A": 1}}	\N
7821999	7815081	c.7123G>A/c.11120G>T	{"RYR1": {"c.7123G>A": 1, "c.11120G>T": 1}}	\N
7822000	7815081	c.6487C>T/c.14639T>C	{"RYR1": {"c.6487C>T": 1, "c.14639T>C": 1}}	\N
7822001	7815081	c.1598G>A/c.7076G>A	{"RYR1": {"c.1598G>A": 1, "c.7076G>A": 1}}	\N
7822002	7815081	c.7291G>A/c.8926C>T	{"RYR1": {"c.7291G>A": 1, "c.8926C>T": 1}}	\N
7822003	7815081	c.6838G>A/c.7089C>G	{"RYR1": {"c.6838G>A": 1, "c.7089C>G": 1}}	\N
7822004	7815081	c.7060G>A/c.14782A>G	{"RYR1": {"c.7060G>A": 1, "c.14782A>G": 1}}	\N
7822005	7815081	c.947G>T/c.7076G>A	{"RYR1": {"c.947G>T": 1, "c.7076G>A": 1}}	\N
7822006	7815081	c.1615T>G/c.14968A>G	{"RYR1": {"c.1615T>G": 1, "c.14968A>G": 1}}	\N
7822007	7815081	c.7048G>A/c.10043G>A	{"RYR1": {"c.7048G>A": 1, "c.10043G>A": 1}}	\N
7822008	7815081	c.1654C>T/c.5186T>G	{"RYR1": {"c.1654C>T": 1, "c.5186T>G": 1}}	\N
7822009	7815081	c.6671G>A/c.7304G>A	{"RYR1": {"c.6671G>A": 1, "c.7304G>A": 1}}	\N
7822010	7815081	c.13934G>A/c.14512C>G	{"RYR1": {"c.13934G>A": 1, "c.14512C>G": 1}}	\N
7822011	7815081	c.103T>C/c.6757C>T	{"RYR1": {"c.103T>C": 1, "c.6757C>T": 1}}	\N
7822012	7815081	c.6488G>T/c.14825G>T	{"RYR1": {"c.6488G>T": 1, "c.14825G>T": 1}}	\N
7822013	7815081	c.7124G>C/c.15060G>C	{"RYR1": {"c.7124G>C": 1, "c.15060G>C": 1}}	\N
7822014	7815081	c.6037A>C/c.7310C>T	{"RYR1": {"c.6037A>C": 1, "c.7310C>T": 1}}	\N
7822015	7815081	c.467G>A/c.7282G>A	{"RYR1": {"c.467G>A": 1, "c.7282G>A": 1}}	\N
7822016	7815081	c.7043A>G/c.9758T>C	{"RYR1": {"c.7043A>G": 1, "c.9758T>C": 1}}	\N
7822017	7815081	c.9652G>A/c.14545G>A	{"RYR1": {"c.9652G>A": 1, "c.14545G>A": 1}}	\N
7822018	7815081	c.1565A>C/c.6037A>C	{"RYR1": {"c.1565A>C": 1, "c.6037A>C": 1}}	\N
7822019	7815081	c.7354C>T/c.15060G>C	{"RYR1": {"c.7354C>T": 1, "c.15060G>C": 1}}	\N
7822020	7815081	c.1201C>T/c.7522C>G	{"RYR1": {"c.1201C>T": 1, "c.7522C>G": 1}}	\N
7822021	7815081	c.677T>A/c.1597C>T	{"RYR1": {"c.677T>A": 1, "c.1597C>T": 1}}	\N
7822022	7815081	c.7124G>C/c.15059G>C	{"RYR1": {"c.7124G>C": 1, "c.15059G>C": 1}}	\N
7822023	7815081	c.1597C>T/c.8198G>A	{"RYR1": {"c.1597C>T": 1, "c.8198G>A": 1}}	\N
7822024	7815081	c.5441T>A/c.7310C>T	{"RYR1": {"c.5441T>A": 1, "c.7310C>T": 1}}	\N
7822025	7815081	c.1654C>T/c.14817C>A	{"RYR1": {"c.1654C>T": 1, "c.14817C>A": 1}}	\N
7822026	7815081	c.6617C>T/c.6742C>T	{"RYR1": {"c.6617C>T": 1, "c.6742C>T": 1}}	\N
7822027	7815081	c.7372C>T/c.14813T>C	{"RYR1": {"c.7372C>T": 1, "c.14813T>C": 1}}	\N
7822028	7815081	c.2996G>A/c.6488G>T	{"RYR1": {"c.2996G>A": 1, "c.6488G>T": 1}}	\N
7822029	7815081	c.742G>C/c.14879T>A	{"RYR1": {"c.742G>C": 1, "c.14879T>A": 1}}	\N
7822030	7815081	c.487C>T/c.7787C>T	{"RYR1": {"c.487C>T": 1, "c.7787C>T": 1}}	\N
7822031	7815081	c.119G>C/c.11708G>A	{"RYR1": {"c.119G>C": 1, "c.11708G>A": 1}}	\N
7822032	7815081	c.2996G>A/c.6488G>C	{"RYR1": {"c.2996G>A": 1, "c.6488G>C": 1}}	\N
7822033	7815081	c.467G>A/c.982C>T	{"RYR1": {"c.467G>A": 1, "c.982C>T": 1}}	\N
7822034	7815081	c.7099G>A/c.7310C>T	{"RYR1": {"c.7099G>A": 1, "c.7310C>T": 1}}	\N
7822035	7815081	c.6671G>A/c.7304G>T	{"RYR1": {"c.6671G>A": 1, "c.7304G>T": 1}}	\N
7822036	7815081	c.1202G>A/c.14197T>G	{"RYR1": {"c.1202G>A": 1, "c.14197T>G": 1}}	\N
7822037	7815081	c.2996G>A/c.6488G>A	{"RYR1": {"c.2996G>A": 1, "c.6488G>A": 1}}	\N
7822038	7815081	c.190T>C/c.7124G>C	{"RYR1": {"c.190T>C": 1, "c.7124G>C": 1}}	\N
7822039	7815081	c.152C>A/c.7523G>A	{"RYR1": {"c.152C>A": 1, "c.7523G>A": 1}}	\N
7822040	7815081	c.7310C>T/c.14201G>A	{"RYR1": {"c.7310C>T": 1, "c.14201G>A": 1}}	\N
7822041	7815081	c.488G>T/c.11813G>A	{"RYR1": {"c.488G>T": 1, "c.11813G>A": 1}}	\N
7822042	7815081	c.38T>G/c.12242C>T	{"RYR1": {"c.38T>G": 1, "c.12242C>T": 1}}	\N
7822043	7815081	c.6488G>T/c.14968A>G	{"RYR1": {"c.6488G>T": 1, "c.14968A>G": 1}}	\N
7822044	7815081	c.680A>T/c.1841G>T	{"RYR1": {"c.680A>T": 1, "c.1841G>T": 1}}	\N
7822045	7815081	c.1459C>G/c.7373G>T	{"RYR1": {"c.1459C>G": 1, "c.7373G>T": 1}}	\N
7822046	7815081	c.1597C>T/c.2050G>C	{"RYR1": {"c.1597C>T": 1, "c.2050G>C": 1}}	\N
7822047	7815081	c.119G>C/c.6612C>G	{"RYR1": {"c.119G>C": 1, "c.6612C>G": 1}}	\N
7822048	7815081	c.7060G>A/c.13505A>G	{"RYR1": {"c.7060G>A": 1, "c.13505A>G": 1}}	\N
7822049	7815081	c.467G>A/c.14627A>G	{"RYR1": {"c.467G>A": 1, "c.14627A>G": 1}}	\N
7822050	7815081	c.6612C>G/c.8005G>A	{"RYR1": {"c.6612C>G": 1, "c.8005G>A": 1}}	\N
7822051	7815081	c.1598G>A/c.7063C>T	{"RYR1": {"c.1598G>A": 1, "c.7063C>T": 1}}	\N
7822052	7815081	c.7360C>T/c.13505A>G	{"RYR1": {"c.7360C>T": 1, "c.13505A>G": 1}}	\N
7822053	7815081	c.9310G>A/c.13672C>T	{"RYR1": {"c.9310G>A": 1, "c.13672C>T": 1}}	\N
7822054	7815081	c.6037A>C/c.11315G>A	{"RYR1": {"c.6037A>C": 1, "c.11315G>A": 1}}	\N
7822055	7815081	c.652G>A/c.14512C>G	{"RYR1": {"c.652G>A": 1, "c.14512C>G": 1}}	\N
7822056	7815081	c.1840C>T/c.14581C>T	{"RYR1": {"c.1840C>T": 1, "c.14581C>T": 1}}	\N
7822057	7815081	c.7042_7044delGAG/c.8518C>T	{"RYR1": {"c.8518C>T": 1, "c.7042_7044delGAG": 1}}	\N
7822058	7815081	c.7036G>A/c.14581C>T	{"RYR1": {"c.7036G>A": 1, "c.14581C>T": 1}}	\N
7822059	7815081	c.7097C>G/c.11969G>T	{"RYR1": {"c.7097C>G": 1, "c.11969G>T": 1}}	\N
7822060	7815081	c.1453A>G/c.1841G>T	{"RYR1": {"c.1453A>G": 1, "c.1841G>T": 1}}	\N
7822061	7815081	c.1100G>T/c.7090T>G	{"RYR1": {"c.1100G>T": 1, "c.7090T>G": 1}}	\N
7822062	7815081	c.463C>A/c.6544A>T	{"RYR1": {"c.463C>A": 1, "c.6544A>T": 1}}	\N
7822063	7815081	c.12532G>A/c.14209C>T	{"RYR1": {"c.12532G>A": 1, "c.14209C>T": 1}}	\N
7822064	7815081	c.6838G>A/c.14509C>G	{"RYR1": {"c.6838G>A": 1, "c.14509C>G": 1}}	\N
7822065	7815081	c.1021G>A/c.7522C>G	{"RYR1": {"c.1021G>A": 1, "c.7522C>G": 1}}	\N
7822066	7815081	c.6617C>T/c.14825G>T	{"RYR1": {"c.6617C>T": 1, "c.14825G>T": 1}}	\N
7822067	7815081	c.7523G>A/c.7760A>G	{"RYR1": {"c.7523G>A": 1, "c.7760A>G": 1}}	\N
7822068	7815081	c.1565A>G/c.7018T>C	{"RYR1": {"c.1565A>G": 1, "c.7018T>C": 1}}	\N
7822069	7815081	c.6487C>T/c.13673G>A	{"RYR1": {"c.6487C>T": 1, "c.13673G>A": 1}}	\N
7822070	7815081	c.11708G>A/c.14567C>G	{"RYR1": {"c.11708G>A": 1, "c.14567C>G": 1}}	\N
7822071	7815081	c.13990T>C/c.14803G>A	{"RYR1": {"c.13990T>C": 1, "c.14803G>A": 1}}	\N
7822072	7815081	c.7007G>A/c.12848A>T	{"RYR1": {"c.7007G>A": 1, "c.12848A>T": 1}}	\N
7822073	7815081	c.11315G>A/c.14879T>A	{"RYR1": {"c.11315G>A": 1, "c.14879T>A": 1}}	\N
7822074	7815081	c.677T>A/c.7310C>T	{"RYR1": {"c.677T>A": 1, "c.7310C>T": 1}}	\N
7822075	7815081	c.97A>G/c.6757C>T	{"RYR1": {"c.97A>G": 1, "c.6757C>T": 1}}	\N
7822076	7815081	c.7358T>C/c.14582G>A	{"RYR1": {"c.7358T>C": 1, "c.14582G>A": 1}}	\N
7822077	7815081	c.11086G>C/c.14497C>T	{"RYR1": {"c.11086G>C": 1, "c.14497C>T": 1}}	\N
7822078	7815081	c.7372C>T/c.14002C>T	{"RYR1": {"c.7372C>T": 1, "c.14002C>T": 1}}	\N
7822079	7815081	c.1589G>A/c.8729C>T	{"RYR1": {"c.1589G>A": 1, "c.8729C>T": 1}}	\N
7822080	7815081	c.6617C>G/c.8198G>A	{"RYR1": {"c.6617C>G": 1, "c.8198G>A": 1}}	\N
7822081	7815081	c.7360C>T/c.14458G>A	{"RYR1": {"c.7360C>T": 1, "c.14458G>A": 1}}	\N
7822082	7815081	c.3172G>A/c.6487C>T	{"RYR1": {"c.3172G>A": 1, "c.6487C>T": 1}}	\N
7822083	7815081	c.742G>C/c.10252A>G	{"RYR1": {"c.742G>C": 1, "c.10252A>G": 1}}	\N
7822084	7815081	c.7042_7044delGAG/c.7777C>G	{"RYR1": {"c.7777C>G": 1, "c.7042_7044delGAG": 1}}	\N
7822085	7815081	c.97A>G/c.12533G>T	{"RYR1": {"c.97A>G": 1, "c.12533G>T": 1}}	\N
7822086	7815081	c.1615T>C/c.14968A>G	{"RYR1": {"c.1615T>C": 1, "c.14968A>G": 1}}	\N
7822087	7815081	c.1840C>T/c.14364+1G>T	{"RYR1": {"c.1840C>T": 1, "c.14364+1G>T": 1}}	\N
7822088	7815081	c.6478G>A/c.14539G>C	{"RYR1": {"c.6478G>A": 1, "c.14539G>C": 1}}	\N
7822089	7815081	c.529C>T/c.7787C>T	{"RYR1": {"c.529C>T": 1, "c.7787C>T": 1}}	\N
7822090	7815081	c.7360C>T/c.14458G>T	{"RYR1": {"c.7360C>T": 1, "c.14458G>T": 1}}	\N
7822091	7815081	c.5440A>G/c.6487C>T	{"RYR1": {"c.5440A>G": 1, "c.6487C>T": 1}}	\N
7822092	7815081	c.7360C>T/c.13702C>G	{"RYR1": {"c.7360C>T": 1, "c.13702C>G": 1}}	\N
7822093	7815081	c.1100G>A/c.14803G>A	{"RYR1": {"c.1100G>A": 1, "c.14803G>A": 1}}	\N
7822094	7815081	c.528G>T/c.14539G>C	{"RYR1": {"c.528G>T": 1, "c.14539G>C": 1}}	\N
7822095	7815081	c.1202G>A/c.12398A>G	{"RYR1": {"c.1202G>A": 1, "c.12398A>G": 1}}	\N
7822096	7815081	c.1615T>G/c.14524G>A	{"RYR1": {"c.1615T>G": 1, "c.14524G>A": 1}}	\N
7822097	7815081	c.488G>A/c.7300G>A	{"RYR1": {"c.488G>A": 1, "c.7300G>A": 1}}	\N
7822098	7815081	c.10556C>T/c.14539G>C	{"RYR1": {"c.10556C>T": 1, "c.14539G>C": 1}}	\N
7822099	7815081	c.7090T>G/c.14197T>G	{"RYR1": {"c.7090T>G": 1, "c.14197T>G": 1}}	\N
7822100	7815081	c.1459C>G/c.7373G>A	{"RYR1": {"c.1459C>G": 1, "c.7373G>A": 1}}	\N
7822101	7815081	c.7523G>A/c.14813T>C	{"RYR1": {"c.7523G>A": 1, "c.14813T>C": 1}}	\N
7822102	7815081	c.6488G>A/c.7778G>A	{"RYR1": {"c.6488G>A": 1, "c.7778G>A": 1}}	\N
7822103	7815081	c.6302T>A/c.7354C>T	{"RYR1": {"c.6302T>A": 1, "c.7354C>T": 1}}	\N
7822104	7815081	c.7372C>T/c.10891G>T	{"RYR1": {"c.7372C>T": 1, "c.10891G>T": 1}}	\N
7822105	7815081	c.6349G>C/c.6710G>A	{"RYR1": {"c.6349G>C": 1, "c.6710G>A": 1}}	\N
7822106	7815081	c.8198G>A/c.14512C>G	{"RYR1": {"c.8198G>A": 1, "c.14512C>G": 1}}	\N
7822107	7815081	c.6838G>A/c.7112A>G	{"RYR1": {"c.6838G>A": 1, "c.7112A>G": 1}}	\N
7822108	7815081	c.7124G>C/c.14693T>C	{"RYR1": {"c.7124G>C": 1, "c.14693T>C": 1}}	\N
7822109	7815081	c.1565A>C/c.9797T>C	{"RYR1": {"c.1565A>C": 1, "c.9797T>C": 1}}	\N
7822110	7815081	c.6671G>A/c.14627A>G	{"RYR1": {"c.6671G>A": 1, "c.14627A>G": 1}}	\N
7822111	7815081	c.7112A>G/c.7124G>C	{"RYR1": {"c.7112A>G": 1, "c.7124G>C": 1}}	\N
7822112	7815081	c.4763C>T/c.11315G>A	{"RYR1": {"c.4763C>T": 1, "c.11315G>A": 1}}	\N
7822113	7815081	c.7099G>A/c.11969G>T	{"RYR1": {"c.7099G>A": 1, "c.11969G>T": 1}}	\N
7822114	7815081	c.7372C>T/c.14270G>A	{"RYR1": {"c.7372C>T": 1, "c.14270G>A": 1}}	\N
7822115	7815081	c.7787C>T/c.11708G>A	{"RYR1": {"c.7787C>T": 1, "c.11708G>A": 1}}	\N
7822116	7815081	c.7043A>G/c.14639T>C	{"RYR1": {"c.7043A>G": 1, "c.14639T>C": 1}}	\N
7822117	7815081	c.7090T>G/c.14818G>A	{"RYR1": {"c.7090T>G": 1, "c.14818G>A": 1}}	\N
7822118	7815081	c.6349G>C/c.7771C>G	{"RYR1": {"c.6349G>C": 1, "c.7771C>G": 1}}	\N
7822119	7815081	c.992_994dup/c.7090T>G	{"RYR1": {"c.7090T>G": 1, "c.992_994dup": 1}}	\N
7822120	7815081	c.6502G>A/c.11120G>T	{"RYR1": {"c.6502G>A": 1, "c.11120G>T": 1}}	\N
7822121	7815081	c.1202G>A/c.14567C>G	{"RYR1": {"c.1202G>A": 1, "c.14567C>G": 1}}	\N
7822122	7815081	c.103T>C/c.14201G>A	{"RYR1": {"c.103T>C": 1, "c.14201G>A": 1}}	\N
7822123	7815081	c.11947C>T/c.14803G>A	{"RYR1": {"c.11947C>T": 1, "c.14803G>A": 1}}	\N
7822124	7815081	c.7310C>T/c.11086G>C	{"RYR1": {"c.7310C>T": 1, "c.11086G>C": 1}}	\N
7822125	7815081	c.7304G>T/c.7355G>C	{"RYR1": {"c.7304G>T": 1, "c.7355G>C": 1}}	\N
7822126	7815081	c.497A>G/c.6617C>G	{"RYR1": {"c.497A>G": 1, "c.6617C>G": 1}}	\N
7822127	7815081	c.7304G>T/c.7355G>A	{"RYR1": {"c.7304G>T": 1, "c.7355G>A": 1}}	\N
7822128	7815081	c.992_994dup/c.5183C>T	{"RYR1": {"c.5183C>T": 1, "c.992_994dup": 1}}	\N
7822129	7815081	c.487C>T/c.8926C>T	{"RYR1": {"c.487C>T": 1, "c.8926C>T": 1}}	\N
7822130	7815081	c.528G>T/c.6502G>A	{"RYR1": {"c.528G>T": 1, "c.6502G>A": 1}}	\N
7822131	7815081	c.6838G>A/c.9868G>A	{"RYR1": {"c.6838G>A": 1, "c.9868G>A": 1}}	\N
7822132	7815081	c.6349G>C/c.7771C>T	{"RYR1": {"c.6349G>C": 1, "c.7771C>T": 1}}	\N
7822133	7815081	c.7210G>A/c.7304G>T	{"RYR1": {"c.7210G>A": 1, "c.7304G>T": 1}}	\N
7822134	7815081	c.6387C>G/c.13990T>C	{"RYR1": {"c.6387C>G": 1, "c.13990T>C": 1}}	\N
7822135	7815081	c.7358T>C/c.14449A>T	{"RYR1": {"c.7358T>C": 1, "c.14449A>T": 1}}	\N
7822136	7815081	c.5183C>T/c.6635T>A	{"RYR1": {"c.5183C>T": 1, "c.6635T>A": 1}}	\N
7822137	7815081	c.1654C>T/c.11132C>T	{"RYR1": {"c.1654C>T": 1, "c.11132C>T": 1}}	\N
7822138	7815081	c.533A>G/c.652G>A	{"RYR1": {"c.533A>G": 1, "c.652G>A": 1}}	\N
7822139	7815081	c.6488G>C/c.7778G>A	{"RYR1": {"c.6488G>C": 1, "c.7778G>A": 1}}	\N
7822140	7815081	c.1565A>C/c.7018T>C	{"RYR1": {"c.1565A>C": 1, "c.7018T>C": 1}}	\N
7822141	7815081	c.982C>T/c.1209C>G	{"RYR1": {"c.982C>T": 1, "c.1209C>G": 1}}	\N
7822142	7815081	c.2537C>T/c.6838G>A	{"RYR1": {"c.2537C>T": 1, "c.6838G>A": 1}}	\N
7822143	7815081	c.947G>T/c.6502G>A	{"RYR1": {"c.947G>T": 1, "c.6502G>A": 1}}	\N
7822144	7815081	c.497A>G/c.6617C>T	{"RYR1": {"c.497A>G": 1, "c.6617C>T": 1}}	\N
7822145	7815081	c.11132C>T/c.12149C>A	{"RYR1": {"c.11132C>T": 1, "c.12149C>A": 1}}	\N
7822146	7815081	c.9797T>C/c.14477C>T	{"RYR1": {"c.9797T>C": 1, "c.14477C>T": 1}}	\N
7822147	7815081	c.641C>T/c.7360C>T	{"RYR1": {"c.641C>T": 1, "c.7360C>T": 1}}	\N
7822148	7815081	c.7036G>A/c.8518C>T	{"RYR1": {"c.7036G>A": 1, "c.8518C>T": 1}}	\N
7822149	7815081	c.7372C>T/c.10043G>A	{"RYR1": {"c.7372C>T": 1, "c.10043G>A": 1}}	\N
7822150	7815081	c.529C>T/c.9635A>G	{"RYR1": {"c.529C>T": 1, "c.9635A>G": 1}}	\N
7822151	7815081	c.7291G>T/c.11947C>T	{"RYR1": {"c.7291G>T": 1, "c.11947C>T": 1}}	\N
7822152	7815081	c.7075C>T/c.7124G>C	{"RYR1": {"c.7075C>T": 1, "c.7124G>C": 1}}	\N
7822153	7815081	c.103T>C/c.7778G>A	{"RYR1": {"c.103T>C": 1, "c.7778G>A": 1}}	\N
7822154	7815081	c.7035C>A/c.7528T>C	{"RYR1": {"c.7035C>A": 1, "c.7528T>C": 1}}	\N
7822155	7815081	c.7291G>A/c.7787C>T	{"RYR1": {"c.7291G>A": 1, "c.7787C>T": 1}}	\N
7822156	7815081	c.4775C>T/c.14803G>A	{"RYR1": {"c.4775C>T": 1, "c.14803G>A": 1}}	\N
7822157	7815081	c.7771C>T/c.14803G>A	{"RYR1": {"c.7771C>T": 1, "c.14803G>A": 1}}	\N
7822158	7815081	c.6488G>T/c.14524G>A	{"RYR1": {"c.6488G>T": 1, "c.14524G>A": 1}}	\N
7822159	7815081	c.130C>T/c.496G>A	{"RYR1": {"c.130C>T": 1, "c.496G>A": 1}}	\N
7822160	7815081	c.1202G>A/c.3127C>T	{"RYR1": {"c.1202G>A": 1, "c.3127C>T": 1}}	\N
7822161	7815081	c.7373G>T/c.12028G>A	{"RYR1": {"c.7373G>T": 1, "c.12028G>A": 1}}	\N
7822162	7815081	c.677T>A/c.14539G>C	{"RYR1": {"c.677T>A": 1, "c.14539G>C": 1}}	\N
7822163	7815081	c.7043A>G/c.10750G>C	{"RYR1": {"c.7043A>G": 1, "c.10750G>C": 1}}	\N
7822164	7815081	c.7358T>C/c.12064A>G	{"RYR1": {"c.7358T>C": 1, "c.12064A>G": 1}}	\N
7822165	7815081	c.7291G>T/c.14680G>A	{"RYR1": {"c.7291G>T": 1, "c.14680G>A": 1}}	\N
7822166	7815081	c.6628G>T/c.14458G>A	{"RYR1": {"c.6628G>T": 1, "c.14458G>A": 1}}	\N
7822167	7815081	c.5132A>G/c.14918C>T	{"RYR1": {"c.5132A>G": 1, "c.14918C>T": 1}}	\N
7822168	7815081	c.1459C>G/c.7361G>A	{"RYR1": {"c.1459C>G": 1, "c.7361G>A": 1}}	\N
7822169	7815081	c.7042_7044delGAG/c.14581C>T	{"RYR1": {"c.14581C>T": 1, "c.7042_7044delGAG": 1}}	\N
7822170	7815081	c.14002C>T/c.14539G>C	{"RYR1": {"c.14002C>T": 1, "c.14539G>C": 1}}	\N
7822171	7815081	c.946C>T/c.14803G>A	{"RYR1": {"c.946C>T": 1, "c.14803G>A": 1}}	\N
7822172	7815081	c.1654C>T/c.7771C>G	{"RYR1": {"c.1654C>T": 1, "c.7771C>G": 1}}	\N
7822173	7815081	c.1615T>C/c.14524G>A	{"RYR1": {"c.1615T>C": 1, "c.14524G>A": 1}}	\N
7822174	7815081	c.1021G>A/c.8188G>C	{"RYR1": {"c.1021G>A": 1, "c.8188G>C": 1}}	\N
7822175	7815081	c.1202G>T/c.12242C>T	{"RYR1": {"c.1202G>T": 1, "c.12242C>T": 1}}	\N
7822176	7815081	c.488G>T/c.5441T>A	{"RYR1": {"c.488G>T": 1, "c.5441T>A": 1}}	\N
7822177	7815081	c.3166G>C/c.5440A>G	{"RYR1": {"c.3166G>C": 1, "c.5440A>G": 1}}	\N
7822178	7815081	c.6710G>A/c.7043A>G	{"RYR1": {"c.6710G>A": 1, "c.7043A>G": 1}}	\N
7822179	7815081	c.1144C>A/c.12700G>C	{"RYR1": {"c.1144C>A": 1, "c.12700G>C": 1}}	\N
7822180	7815081	c.8189A>G/c.14803G>A	{"RYR1": {"c.8189A>G": 1, "c.14803G>A": 1}}	\N
7822181	7815081	c.7522C>T/c.9848G>A	{"RYR1": {"c.7522C>T": 1, "c.9848G>A": 1}}	\N
7822182	7815081	c.6349G>C/c.9758T>C	{"RYR1": {"c.6349G>C": 1, "c.9758T>C": 1}}	\N
7822183	7815081	c.1453A>G/c.7123G>A	{"RYR1": {"c.1453A>G": 1, "c.7123G>A": 1}}	\N
7822184	7815081	c.1840C>T/c.13505A>G	{"RYR1": {"c.1840C>T": 1, "c.13505A>G": 1}}	\N
7822185	7815081	c.641C>T/c.7372C>T	{"RYR1": {"c.641C>T": 1, "c.7372C>T": 1}}	\N
7822186	7815081	c.6628G>T/c.14458G>T	{"RYR1": {"c.6628G>T": 1, "c.14458G>T": 1}}	\N
7822187	7815081	c.7385C>T/c.7523G>A	{"RYR1": {"c.7385C>T": 1, "c.7523G>A": 1}}	\N
7822188	7815081	c.9310G>A/c.10750G>C	{"RYR1": {"c.9310G>A": 1, "c.10750G>C": 1}}	\N
7822189	7815081	c.5890C>T/c.14210G>A	{"RYR1": {"c.5890C>T": 1, "c.14210G>A": 1}}	\N
7822190	7815081	c.1144C>A/c.12700G>T	{"RYR1": {"c.1144C>A": 1, "c.12700G>T": 1}}	\N
7822191	7815081	c.2924G>A/c.14627A>G	{"RYR1": {"c.2924G>A": 1, "c.14627A>G": 1}}	\N
7822192	7815081	c.8600T>A/c.14627A>G	{"RYR1": {"c.8600T>A": 1, "c.14627A>G": 1}}	\N
7822193	7815081	c.103T>C/c.152C>A	{"RYR1": {"c.103T>C": 1, "c.152C>A": 1}}	\N
7822194	7815081	c.3166G>C/c.7073T>A	{"RYR1": {"c.3166G>C": 1, "c.7073T>A": 1}}	\N
7822195	7815081	c.7076G>A/c.11723A>T	{"RYR1": {"c.7076G>A": 1, "c.11723A>T": 1}}	\N
7822196	7815081	c.97A>G/c.119G>C	{"RYR1": {"c.97A>G": 1, "c.119G>C": 1}}	\N
7822197	7815081	c.6037A>C/c.6349G>C	{"RYR1": {"c.6037A>C": 1, "c.6349G>C": 1}}	\N
7822198	7815081	c.467G>A/c.7063C>T	{"RYR1": {"c.467G>A": 1, "c.7063C>T": 1}}	\N
7822199	7815081	c.1630G>T/c.9268G>A	{"RYR1": {"c.1630G>T": 1, "c.9268G>A": 1}}	\N
7822200	7815081	c.1021G>C/c.7355G>A	{"RYR1": {"c.1021G>C": 1, "c.7355G>A": 1}}	\N
7822201	7815081	c.5183C>T/c.12028G>A	{"RYR1": {"c.5183C>T": 1, "c.12028G>A": 1}}	\N
7822202	7815081	c.1021G>C/c.7355G>C	{"RYR1": {"c.1021G>C": 1, "c.7355G>C": 1}}	\N
7822203	7815081	c.529C>T/c.15059G>C	{"RYR1": {"c.529C>T": 1, "c.15059G>C": 1}}	\N
7822204	7815081	c.1021G>C/c.8188G>C	{"RYR1": {"c.1021G>C": 1, "c.8188G>C": 1}}	\N
7822205	7815081	c.1565A>C/c.7085A>G	{"RYR1": {"c.1565A>C": 1, "c.7085A>G": 1}}	\N
7822206	7815081	c.7522C>T/c.8005G>A	{"RYR1": {"c.7522C>T": 1, "c.8005G>A": 1}}	\N
7822207	7815081	c.6488G>C/c.14449A>T	{"RYR1": {"c.6488G>C": 1, "c.14449A>T": 1}}	\N
7822208	7815081	c.1615T>C/c.7777C>G	{"RYR1": {"c.1615T>C": 1, "c.7777C>G": 1}}	\N
7822209	7815081	c.529C>T/c.12848A>T	{"RYR1": {"c.529C>T": 1, "c.12848A>T": 1}}	\N
7822210	7815081	c.467G>A/c.6502G>A	{"RYR1": {"c.467G>A": 1, "c.6502G>A": 1}}	\N
7822211	7815081	c.1565A>G/c.7099G>A	{"RYR1": {"c.1565A>G": 1, "c.7099G>A": 1}}	\N
7822212	7815081	c.463C>A/c.6635T>A	{"RYR1": {"c.463C>A": 1, "c.6635T>A": 1}}	\N
7822213	7815081	c.6671G>A/c.7076G>A	{"RYR1": {"c.6671G>A": 1, "c.7076G>A": 1}}	\N
7822214	7815081	c.7523G>A/c.10042C>T	{"RYR1": {"c.7523G>A": 1, "c.10042C>T": 1}}	\N
7822215	7815081	c.1201C>A/c.7523G>A	{"RYR1": {"c.1201C>A": 1, "c.7523G>A": 1}}	\N
7822216	7815081	c.7123G>A/c.7199A>G	{"RYR1": {"c.7123G>A": 1, "c.7199A>G": 1}}	\N
7822217	7815081	c.7123G>A/c.7879G>A	{"RYR1": {"c.7123G>A": 1, "c.7879G>A": 1}}	\N
7822218	7815081	c.13990T>C/c.14477C>T	{"RYR1": {"c.13990T>C": 1, "c.14477C>T": 1}}	\N
7822219	7815081	c.12355A>T/c.14918C>T	{"RYR1": {"c.12355A>T": 1, "c.14918C>T": 1}}	\N
7822220	7815081	c.1024G>A/c.7090T>G	{"RYR1": {"c.1024G>A": 1, "c.7090T>G": 1}}	\N
7822221	7815081	c.1654C>T/c.7771C>T	{"RYR1": {"c.1654C>T": 1, "c.7771C>T": 1}}	\N
7822222	7815081	c.1202G>A/c.8189A>G	{"RYR1": {"c.1202G>A": 1, "c.8189A>G": 1}}	\N
7822223	7815081	c.529C>T/c.15060G>C	{"RYR1": {"c.529C>T": 1, "c.15060G>C": 1}}	\N
7822224	7815081	c.3166G>C/c.5024T>C	{"RYR1": {"c.3166G>C": 1, "c.5024T>C": 1}}	\N
7822225	7815081	c.5183C>T/c.12532G>A	{"RYR1": {"c.5183C>T": 1, "c.12532G>A": 1}}	\N
7822226	7815081	c.1209C>G/c.11315G>A	{"RYR1": {"c.1209C>G": 1, "c.11315G>A": 1}}	\N
7822227	7815081	c.6838G>A/c.8527T>C	{"RYR1": {"c.6838G>A": 1, "c.8527T>C": 1}}	\N
7822228	7815081	c.6387C>G/c.12115A>T	{"RYR1": {"c.6387C>G": 1, "c.12115A>T": 1}}	\N
7822229	7815081	c.7076G>A/c.15059G>C	{"RYR1": {"c.7076G>A": 1, "c.15059G>C": 1}}	\N
7822230	7815081	c.7090T>G/c.9868G>A	{"RYR1": {"c.7090T>G": 1, "c.9868G>A": 1}}	\N
7822231	7815081	c.7043A>G/c.10229C>A	{"RYR1": {"c.7043A>G": 1, "c.10229C>A": 1}}	\N
7822232	7815081	c.190T>C/c.7282G>A	{"RYR1": {"c.190T>C": 1, "c.7282G>A": 1}}	\N
7822233	7815081	c.1411C>T/c.7042_7044delGAG	{"RYR1": {"c.1411C>T": 1, "c.7042_7044delGAG": 1}}	\N
7822234	7815081	c.488G>T/c.6544A>T	{"RYR1": {"c.488G>T": 1, "c.6544A>T": 1}}	\N
7822235	7815081	c.7522C>T/c.12848A>T	{"RYR1": {"c.7522C>T": 1, "c.12848A>T": 1}}	\N
7822236	7815081	c.533A>G/c.5132A>G	{"RYR1": {"c.533A>G": 1, "c.5132A>G": 1}}	\N
7822237	7815081	c.5024T>C/c.7354C>T	{"RYR1": {"c.5024T>C": 1, "c.7354C>T": 1}}	\N
7822238	7815081	c.190T>C/c.982C>T	{"RYR1": {"c.190T>C": 1, "c.982C>T": 1}}	\N
7822239	7815081	c.11518G>A/c.12700G>C	{"RYR1": {"c.11518G>A": 1, "c.12700G>C": 1}}	\N
7822240	7815081	c.7291G>T/c.14424C>A	{"RYR1": {"c.7291G>T": 1, "c.14424C>A": 1}}	\N
7822241	7815081	c.14210G>A/c.14968A>G	{"RYR1": {"c.14210G>A": 1, "c.14968A>G": 1}}	\N
7822242	7815081	c.7043A>G/c.14814C>G	{"RYR1": {"c.7043A>G": 1, "c.14814C>G": 1}}	\N
7822243	7815081	c.6302T>A/c.14803G>A	{"RYR1": {"c.6302T>A": 1, "c.14803G>A": 1}}	\N
7822244	7815081	c.1589G>A/c.7778G>A	{"RYR1": {"c.1589G>A": 1, "c.7778G>A": 1}}	\N
7822245	7815081	c.7310C>T/c.14968A>G	{"RYR1": {"c.7310C>T": 1, "c.14968A>G": 1}}	\N
7822246	7815081	c.7036G>A/c.14782A>G	{"RYR1": {"c.7036G>A": 1, "c.14782A>G": 1}}	\N
7822247	7815081	c.1840C>T/c.14387A>G	{"RYR1": {"c.1840C>T": 1, "c.14387A>G": 1}}	\N
7822248	7815081	c.6488G>A/c.14449A>T	{"RYR1": {"c.6488G>A": 1, "c.14449A>T": 1}}	\N
7822249	7815081	c.7048G>A/c.15059G>C	{"RYR1": {"c.7048G>A": 1, "c.15059G>C": 1}}	\N
7822250	7815081	c.11518G>A/c.12700G>T	{"RYR1": {"c.11518G>A": 1, "c.12700G>T": 1}}	\N
7822251	7815081	c.496G>A/c.1630G>T	{"RYR1": {"c.496G>A": 1, "c.1630G>T": 1}}	\N
7822252	7815081	c.1453A>G/c.6617C>T	{"RYR1": {"c.1453A>G": 1, "c.6617C>T": 1}}	\N
7822253	7815081	c.7210G>A/c.14545G>A	{"RYR1": {"c.7210G>A": 1, "c.14545G>A": 1}}	\N
7822254	7815081	c.1459C>G/c.7879G>C	{"RYR1": {"c.1459C>G": 1, "c.7879G>C": 1}}	\N
7822255	7815081	c.1589G>A/c.6742C>T	{"RYR1": {"c.1589G>A": 1, "c.6742C>T": 1}}	\N
7822256	7815081	c.6387C>G/c.14879T>A	{"RYR1": {"c.6387C>G": 1, "c.14879T>A": 1}}	\N
7822257	7815081	c.1459C>G/c.7300G>A	{"RYR1": {"c.1459C>G": 1, "c.7300G>A": 1}}	\N
7822258	7815081	c.103T>C/c.8729C>T	{"RYR1": {"c.103T>C": 1, "c.8729C>T": 1}}	\N
7822259	7815081	c.5132A>G/c.7523G>A	{"RYR1": {"c.5132A>G": 1, "c.7523G>A": 1}}	\N
7822260	7815081	c.7076G>A/c.15060G>C	{"RYR1": {"c.7076G>A": 1, "c.15060G>C": 1}}	\N
7822261	7815081	c.7210G>A/c.7304G>A	{"RYR1": {"c.7210G>A": 1, "c.7304G>A": 1}}	\N
7822262	7815081	c.7048G>A/c.15060G>C	{"RYR1": {"c.7048G>A": 1, "c.15060G>C": 1}}	\N
7822263	7815081	c.1565A>C/c.6640G>A	{"RYR1": {"c.1565A>C": 1, "c.6640G>A": 1}}	\N
7822264	7815081	c.14210G>A/c.14581C>T	{"RYR1": {"c.14210G>A": 1, "c.14581C>T": 1}}	\N
7822265	7815081	c.652G>A/c.6838G>A	{"RYR1": {"c.652G>A": 1, "c.6838G>A": 1}}	\N
7822266	7815081	c.7048G>A/c.9635A>G	{"RYR1": {"c.7048G>A": 1, "c.9635A>G": 1}}	\N
7822267	7815081	c.8188G>C/c.9310G>A	{"RYR1": {"c.8188G>C": 1, "c.9310G>A": 1}}	\N
7822268	7815081	c.3166G>C/c.10891G>T	{"RYR1": {"c.3166G>C": 1, "c.10891G>T": 1}}	\N
7822269	7815081	c.1597C>T/c.7112A>G	{"RYR1": {"c.1597C>T": 1, "c.7112A>G": 1}}	\N
7822270	7815081	c.6488G>T/c.7777C>G	{"RYR1": {"c.6488G>T": 1, "c.7777C>G": 1}}	\N
7822271	7815081	c.6612C>G/c.7317G>C	{"RYR1": {"c.6612C>G": 1, "c.7317G>C": 1}}	\N
7822272	7815081	c.13994_13995delTCinsCT/c.14512C>G	{"RYR1": {"c.14512C>G": 1, "c.13994_13995delTCinsCT": 1}}	\N
7822273	7815081	c.7060G>A/c.11126C>T	{"RYR1": {"c.7060G>A": 1, "c.11126C>T": 1}}	\N
7822274	7815081	c.1615T>G/c.10556C>T	{"RYR1": {"c.1615T>G": 1, "c.10556C>T": 1}}	\N
7822275	7815081	c.6617C>G/c.8518C>T	{"RYR1": {"c.6617C>G": 1, "c.8518C>T": 1}}	\N
7822276	7815081	c.2924G>A/c.7035C>A	{"RYR1": {"c.2924G>A": 1, "c.7035C>A": 1}}	\N
7822277	7815081	c.7385C>T/c.14918C>T	{"RYR1": {"c.7385C>T": 1, "c.14918C>T": 1}}	\N
7822278	7815081	c.6617C>G/c.7778G>A	{"RYR1": {"c.6617C>G": 1, "c.7778G>A": 1}}	\N
7822279	7815081	c.1209C>G/c.7042_7044delGAG	{"RYR1": {"c.1209C>G": 1, "c.7042_7044delGAG": 1}}	\N
7822280	7815081	c.11120G>T/c.12700G>T	{"RYR1": {"c.11120G>T": 1, "c.12700G>T": 1}}	\N
7822281	7815081	c.6488G>A/c.14825G>T	{"RYR1": {"c.6488G>A": 1, "c.14825G>T": 1}}	\N
7822282	7815081	c.7007G>A/c.7317G>C	{"RYR1": {"c.7007G>A": 1, "c.7317G>C": 1}}	\N
7822283	7815081	c.493G>A/c.1615T>C	{"RYR1": {"c.493G>A": 1, "c.1615T>C": 1}}	\N
7822284	7815081	c.7099G>A/c.14539G>C	{"RYR1": {"c.7099G>A": 1, "c.14539G>C": 1}}	\N
7822285	7815081	c.6488G>C/c.8518C>T	{"RYR1": {"c.6488G>C": 1, "c.8518C>T": 1}}	\N
7822286	7815081	c.7042_7044delGAG/c.14968A>G	{"RYR1": {"c.14968A>G": 1, "c.7042_7044delGAG": 1}}	\N
7822287	7815081	c.1565A>G/c.7085A>G	{"RYR1": {"c.1565A>G": 1, "c.7085A>G": 1}}	\N
7822288	7815081	c.11120G>T/c.12700G>C	{"RYR1": {"c.11120G>T": 1, "c.12700G>C": 1}}	\N
7822289	7815081	c.11813G>A/c.14209C>T	{"RYR1": {"c.11813G>A": 1, "c.14209C>T": 1}}	\N
7822290	7815081	c.1201C>A/c.14918C>T	{"RYR1": {"c.1201C>A": 1, "c.14918C>T": 1}}	\N
7822291	7815081	c.1615T>G/c.7777C>G	{"RYR1": {"c.1615T>G": 1, "c.7777C>G": 1}}	\N
7822292	7815081	c.6617C>G/c.14825G>T	{"RYR1": {"c.6617C>G": 1, "c.14825G>T": 1}}	\N
7822293	7815081	c.7048G>A/c.7317G>C	{"RYR1": {"c.7048G>A": 1, "c.7317G>C": 1}}	\N
7822294	7815081	c.103T>C/c.14825G>T	{"RYR1": {"c.103T>C": 1, "c.14825G>T": 1}}	\N
7822295	7815081	c.992_994dup/c.14477C>T	{"RYR1": {"c.14477C>T": 1, "c.992_994dup": 1}}	\N
7822296	7815081	c.1597C>T/c.6743G>A	{"RYR1": {"c.1597C>T": 1, "c.6743G>A": 1}}	\N
7822297	7815081	c.1840C>T/c.11126C>T	{"RYR1": {"c.1840C>T": 1, "c.11126C>T": 1}}	\N
7822298	7815081	c.7063C>T/c.14818G>A	{"RYR1": {"c.7063C>T": 1, "c.14818G>A": 1}}	\N
7822299	7815081	c.3166G>C/c.11947C>T	{"RYR1": {"c.3166G>C": 1, "c.11947C>T": 1}}	\N
7822300	7815081	c.97A>G/c.6710G>A	{"RYR1": {"c.97A>G": 1, "c.6710G>A": 1}}	\N
7822301	7815081	c.488G>A/c.12700G>T	{"RYR1": {"c.488G>A": 1, "c.12700G>T": 1}}	\N
7822302	7815081	c.1841G>T/c.5132A>G	{"RYR1": {"c.1841G>T": 1, "c.5132A>G": 1}}	\N
7822303	7815081	c.6349G>C/c.14817C>A	{"RYR1": {"c.6349G>C": 1, "c.14817C>A": 1}}	\N
7822304	7815081	c.5441T>A/c.14539G>C	{"RYR1": {"c.5441T>A": 1, "c.14539G>C": 1}}	\N
7822305	7815081	c.533A>G/c.10043G>A	{"RYR1": {"c.533A>G": 1, "c.10043G>A": 1}}	\N
7822306	7815081	c.6617C>G/c.6742C>T	{"RYR1": {"c.6617C>G": 1, "c.6742C>T": 1}}	\N
7822307	7815081	c.38T>G/c.11416G>A	{"RYR1": {"c.38T>G": 1, "c.11416G>A": 1}}	\N
7822308	7815081	c.12533G>T/c.14539G>C	{"RYR1": {"c.12533G>T": 1, "c.14539G>C": 1}}	\N
7822309	7815081	c.7771C>G/c.8026C>T	{"RYR1": {"c.7771C>G": 1, "c.8026C>T": 1}}	\N
7822310	7815081	c.488G>A/c.12700G>C	{"RYR1": {"c.488G>A": 1, "c.12700G>C": 1}}	\N
7822311	7815081	c.1654C>T/c.4775C>T	{"RYR1": {"c.1654C>T": 1, "c.4775C>T": 1}}	\N
7822312	7815081	c.6488G>A/c.12064A>G	{"RYR1": {"c.6488G>A": 1, "c.12064A>G": 1}}	\N
7822313	7815081	c.6628G>T/c.13505A>G	{"RYR1": {"c.6628G>T": 1, "c.13505A>G": 1}}	\N
7822314	7815081	c.493G>A/c.1615T>G	{"RYR1": {"c.493G>A": 1, "c.1615T>G": 1}}	\N
7822315	7815081	c.1202G>T/c.14197T>G	{"RYR1": {"c.1202G>T": 1, "c.14197T>G": 1}}	\N
7822316	7815081	c.14210G>A/c.14678G>A	{"RYR1": {"c.14210G>A": 1, "c.14678G>A": 1}}	\N
7822317	7815081	c.6617C>T/c.14968A>G	{"RYR1": {"c.6617C>T": 1, "c.14968A>G": 1}}	\N
7822318	7815081	c.7043A>G/c.13672C>T	{"RYR1": {"c.7043A>G": 1, "c.13672C>T": 1}}	\N
7822319	7815081	c.2122G>A/c.7007G>A	{"RYR1": {"c.2122G>A": 1, "c.7007G>A": 1}}	\N
7822320	7815081	c.6640G>A/c.7043A>G	{"RYR1": {"c.6640G>A": 1, "c.7043A>G": 1}}	\N
7822321	7815081	c.12064A>G/c.14545G>A	{"RYR1": {"c.12064A>G": 1, "c.14545G>A": 1}}	\N
7822322	7815081	c.1630G>T/c.2050G>C	{"RYR1": {"c.1630G>T": 1, "c.2050G>C": 1}}	\N
7822323	7815081	c.7036G>A/c.13760C>T	{"RYR1": {"c.7036G>A": 1, "c.13760C>T": 1}}	\N
7822324	7815081	c.12383C>T/c.14803G>A	{"RYR1": {"c.12383C>T": 1, "c.14803G>A": 1}}	\N
7822325	7815081	c.1021G>A/c.7355G>C	{"RYR1": {"c.1021G>A": 1, "c.7355G>C": 1}}	\N
7822326	7815081	c.6742C>T/c.14497C>T	{"RYR1": {"c.6742C>T": 1, "c.14497C>T": 1}}	\N
7822327	7815081	c.8638G>A/c.14539G>C	{"RYR1": {"c.8638G>A": 1, "c.14539G>C": 1}}	\N
7822328	7815081	c.6488G>A/c.8518C>T	{"RYR1": {"c.6488G>A": 1, "c.8518C>T": 1}}	\N
7822329	7815081	c.7523G>A/c.11813G>A	{"RYR1": {"c.7523G>A": 1, "c.11813G>A": 1}}	\N
7822330	7815081	c.9310G>A/c.12413T>C	{"RYR1": {"c.9310G>A": 1, "c.12413T>C": 1}}	\N
7822331	7815081	c.7360C>T/c.14387A>G	{"RYR1": {"c.7360C>T": 1, "c.14387A>G": 1}}	\N
7822332	7815081	c.9310G>A/c.9499C>T	{"RYR1": {"c.9310G>A": 1, "c.9499C>T": 1}}	\N
7822333	7815081	c.1021G>A/c.7355G>A	{"RYR1": {"c.1021G>A": 1, "c.7355G>A": 1}}	\N
7822334	7815081	c.625G>A/c.11315G>A	{"RYR1": {"c.625G>A": 1, "c.11315G>A": 1}}	\N
7822335	7815081	c.6599C>T/c.7522C>T	{"RYR1": {"c.6599C>T": 1, "c.7522C>T": 1}}	\N
7822336	7815081	c.7778G>A/c.14209C>T	{"RYR1": {"c.7778G>A": 1, "c.14209C>T": 1}}	\N
7822337	7815081	c.1589G>A/c.14825G>T	{"RYR1": {"c.1589G>A": 1, "c.14825G>T": 1}}	\N
7822338	7815081	c.1841G>T/c.10043G>A	{"RYR1": {"c.1841G>T": 1, "c.10043G>A": 1}}	\N
7822339	7815081	c.130C>T/c.7199A>G	{"RYR1": {"c.130C>T": 1, "c.7199A>G": 1}}	\N
7822340	7815081	c.1841G>T/c.14051T>C	{"RYR1": {"c.1841G>T": 1, "c.14051T>C": 1}}	\N
7822341	7815081	c.529C>T/c.7317G>C	{"RYR1": {"c.529C>T": 1, "c.7317G>C": 1}}	\N
7822342	7815081	c.6488G>C/c.14825G>T	{"RYR1": {"c.6488G>C": 1, "c.14825G>T": 1}}	\N
7822343	7815081	c.7043A>G/c.12242C>T	{"RYR1": {"c.7043A>G": 1, "c.12242C>T": 1}}	\N
7822344	7815081	c.7048G>A/c.12848A>T	{"RYR1": {"c.7048G>A": 1, "c.12848A>T": 1}}	\N
7822345	7815081	c.38T>G/c.13994_13995delTCinsCT	{"RYR1": {"c.38T>G": 1, "c.13994_13995delTCinsCT": 1}}	\N
7822346	7815081	c.1654C>T/c.4763C>T	{"RYR1": {"c.1654C>T": 1, "c.4763C>T": 1}}	\N
7822347	7815081	c.1411C>T/c.11315G>A	{"RYR1": {"c.1411C>T": 1, "c.11315G>A": 1}}	\N
7822348	7815081	c.7097C>G/c.14539G>C	{"RYR1": {"c.7097C>G": 1, "c.14539G>C": 1}}	\N
7822349	7815081	c.526G>A/c.7522C>T	{"RYR1": {"c.526G>A": 1, "c.7522C>T": 1}}	\N
7822350	7815081	c.1201C>G/c.7523G>A	{"RYR1": {"c.1201C>G": 1, "c.7523G>A": 1}}	\N
7822351	7815081	c.6487C>T/c.8654C>G	{"RYR1": {"c.6487C>T": 1, "c.8654C>G": 1}}	\N
7822352	7815081	c.5890C>T/c.6617C>G	{"RYR1": {"c.5890C>T": 1, "c.6617C>G": 1}}	\N
7822353	7815081	c.5890C>T/c.6617C>T	{"RYR1": {"c.5890C>T": 1, "c.6617C>T": 1}}	\N
7822354	7815081	c.7304G>T/c.12028G>A	{"RYR1": {"c.7304G>T": 1, "c.12028G>A": 1}}	\N
7822355	7815081	c.3166G>C/c.3527C>T	{"RYR1": {"c.3166G>C": 1, "c.3527C>T": 1}}	\N
7822356	7815081	c.1565A>G/c.6640G>A	{"RYR1": {"c.1565A>G": 1, "c.6640G>A": 1}}	\N
7822357	7815081	c.6502G>A/c.7032G>C	{"RYR1": {"c.6502G>A": 1, "c.7032G>C": 1}}	\N
7822358	7815081	c.9310G>A/c.14422_14423delinsAA	{"RYR1": {"c.9310G>A": 1, "c.14422_14423delinsAA": 1}}	\N
7822359	7815081	c.12121C>T/c.14497C>T	{"RYR1": {"c.12121C>T": 1, "c.14497C>T": 1}}	\N
7822360	7815081	c.7317G>C/c.8026C>T	{"RYR1": {"c.7317G>C": 1, "c.8026C>T": 1}}	\N
7822361	7815081	c.8654C>G/c.11315G>A	{"RYR1": {"c.8654C>G": 1, "c.11315G>A": 1}}	\N
7822362	7815081	c.1565A>G/c.9797T>C	{"RYR1": {"c.1565A>G": 1, "c.9797T>C": 1}}	\N
7822363	7815081	c.97A>G/c.9356G>A	{"RYR1": {"c.97A>G": 1, "c.9356G>A": 1}}	\N
7822364	7815081	c.6757C>T/c.7090T>G	{"RYR1": {"c.6757C>T": 1, "c.7090T>G": 1}}	\N
7822365	7815081	c.251C>T/c.742G>A	{"RYR1": {"c.251C>T": 1, "c.742G>A": 1}}	\N
7822366	7815081	c.7112A>G/c.12149C>A	{"RYR1": {"c.7112A>G": 1, "c.12149C>A": 1}}	\N
7822367	7815081	c.7291G>A/c.9850T>A	{"RYR1": {"c.7291G>A": 1, "c.9850T>A": 1}}	\N
7822368	7815081	c.251C>T/c.742G>C	{"RYR1": {"c.251C>T": 1, "c.742G>C": 1}}	\N
7822369	7815081	c.7007G>A/c.14567C>G	{"RYR1": {"c.7007G>A": 1, "c.14567C>G": 1}}	\N
7822370	7815081	c.7112A>G/c.11708G>A	{"RYR1": {"c.7112A>G": 1, "c.11708G>A": 1}}	\N
7822371	7815081	c.1841G>T/c.12242C>T	{"RYR1": {"c.1841G>T": 1, "c.12242C>T": 1}}	\N
7822372	7815081	c.7291G>A/c.14678G>A	{"RYR1": {"c.7291G>A": 1, "c.14678G>A": 1}}	\N
7822373	7815081	c.12398A>G/c.14803G>A	{"RYR1": {"c.12398A>G": 1, "c.14803G>A": 1}}	\N
7822374	7815081	c.6488G>C/c.6743G>A	{"RYR1": {"c.6488G>C": 1, "c.6743G>A": 1}}	\N
7822375	7815081	c.1021G>C/c.6743G>A	{"RYR1": {"c.1021G>C": 1, "c.6743G>A": 1}}	\N
7822376	7815081	c.1840C>T/c.7075C>T	{"RYR1": {"c.1840C>T": 1, "c.7075C>T": 1}}	\N
7822377	7815081	c.3527C>T/c.14803G>A	{"RYR1": {"c.3527C>T": 1, "c.14803G>A": 1}}	\N
7822378	7815081	c.1201C>A/c.14497C>T	{"RYR1": {"c.1201C>A": 1, "c.14497C>T": 1}}	\N
7822379	7815081	c.7048G>A/c.13918A>G	{"RYR1": {"c.7048G>A": 1, "c.13918A>G": 1}}	\N
7822380	7815081	c.6599C>T/c.14209C>T	{"RYR1": {"c.6599C>T": 1, "c.14209C>T": 1}}	\N
7822381	7815081	c.1630G>T/c.13702C>G	{"RYR1": {"c.1630G>T": 1, "c.13702C>G": 1}}	\N
7822382	7815081	c.6487C>T/c.8188G>C	{"RYR1": {"c.6487C>T": 1, "c.8188G>C": 1}}	\N
7822383	7815081	c.7036G>A/c.7085A>G	{"RYR1": {"c.7036G>A": 1, "c.7085A>G": 1}}	\N
7822384	7815081	c.493G>A/c.14477C>T	{"RYR1": {"c.493G>A": 1, "c.14477C>T": 1}}	\N
7822385	7815081	c.1834G>C/c.7300G>A	{"RYR1": {"c.1834G>C": 1, "c.7300G>A": 1}}	\N
7822386	7815081	c.742G>C/c.1553T>C	{"RYR1": {"c.742G>C": 1, "c.1553T>C": 1}}	\N
7822387	7815081	c.1840C>T/c.10043G>A	{"RYR1": {"c.1840C>T": 1, "c.10043G>A": 1}}	\N
7822388	7815081	c.1615T>G/c.14471T>C	{"RYR1": {"c.1615T>G": 1, "c.14471T>C": 1}}	\N
7822389	7815081	c.1021G>A/c.7528T>C	{"RYR1": {"c.1021G>A": 1, "c.7528T>C": 1}}	\N
7822390	7815081	c.6838G>A/c.12848A>T	{"RYR1": {"c.6838G>A": 1, "c.12848A>T": 1}}	\N
7822391	7815081	c.742G>A/c.1209C>G	{"RYR1": {"c.742G>A": 1, "c.1209C>G": 1}}	\N
7822392	7815081	c.14782A>G/c.14803G>A	{"RYR1": {"c.14782A>G": 1, "c.14803G>A": 1}}	\N
7822393	7815081	c.6349G>C/c.9797T>C	{"RYR1": {"c.6349G>C": 1, "c.9797T>C": 1}}	\N
7822394	7815081	c.7358T>C/c.11947C>T	{"RYR1": {"c.7358T>C": 1, "c.11947C>T": 1}}	\N
7822395	7815081	c.6488G>A/c.14558C>T	{"RYR1": {"c.6488G>A": 1, "c.14558C>T": 1}}	\N
7822396	7815081	c.3418C>T/c.6488G>A	{"RYR1": {"c.3418C>T": 1, "c.6488G>A": 1}}	\N
7822397	7815081	c.38T>G/c.14567C>G	{"RYR1": {"c.38T>G": 1, "c.14567C>G": 1}}	\N
7822398	7815081	c.12149C>A/c.14422_14423delinsAA	{"RYR1": {"c.12149C>A": 1, "c.14422_14423delinsAA": 1}}	\N
7822399	7815081	c.1841G>T/c.4400A>G	{"RYR1": {"c.1841G>T": 1, "c.4400A>G": 1}}	\N
7822400	7815081	c.3418C>T/c.6488G>C	{"RYR1": {"c.3418C>T": 1, "c.6488G>C": 1}}	\N
7822401	7815081	c.1201C>T/c.13918A>G	{"RYR1": {"c.1201C>T": 1, "c.13918A>G": 1}}	\N
7822402	7815081	c.7042_7044delGAG/c.9268G>A	{"RYR1": {"c.9268G>A": 1, "c.7042_7044delGAG": 1}}	\N
7822403	7815081	c.7043A>G/c.14051T>C	{"RYR1": {"c.7043A>G": 1, "c.14051T>C": 1}}	\N
7822404	7815081	c.742G>C/c.14186A>C	{"RYR1": {"c.742G>C": 1, "c.14186A>C": 1}}	\N
7822405	7815081	c.7124G>C/c.7771C>T	{"RYR1": {"c.7124G>C": 1, "c.7771C>T": 1}}	\N
7822406	7815081	c.3418C>T/c.6488G>T	{"RYR1": {"c.3418C>T": 1, "c.6488G>T": 1}}	\N
7822407	7815081	c.1100G>T/c.1615T>G	{"RYR1": {"c.1100G>T": 1, "c.1615T>G": 1}}	\N
7822408	7815081	c.1565A>C/c.14813T>C	{"RYR1": {"c.1565A>C": 1, "c.14813T>C": 1}}	\N
7822409	7815081	c.8026C>T/c.9635A>G	{"RYR1": {"c.8026C>T": 1, "c.9635A>G": 1}}	\N
7822410	7815081	c.1654C>T/c.7879G>A	{"RYR1": {"c.1654C>T": 1, "c.7879G>A": 1}}	\N
7822411	7815081	c.7035C>A/c.9652G>A	{"RYR1": {"c.7035C>A": 1, "c.9652G>A": 1}}	\N
7822412	7815081	c.1100G>T/c.1615T>C	{"RYR1": {"c.1100G>T": 1, "c.1615T>C": 1}}	\N
7822413	7815081	c.488G>T/c.6037A>C	{"RYR1": {"c.488G>T": 1, "c.6037A>C": 1}}	\N
7822414	7815081	c.7124G>C/c.7771C>G	{"RYR1": {"c.7124G>C": 1, "c.7771C>G": 1}}	\N
7822415	7815081	c.1021G>A/c.6743G>A	{"RYR1": {"c.1021G>A": 1, "c.6743G>A": 1}}	\N
7822416	7815081	c.130C>T/c.4747C>T	{"RYR1": {"c.130C>T": 1, "c.4747C>T": 1}}	\N
7822417	7815081	c.742G>A/c.1553T>C	{"RYR1": {"c.742G>A": 1, "c.1553T>C": 1}}	\N
7822418	7815081	c.1565A>G/c.13505A>G	{"RYR1": {"c.1565A>G": 1, "c.13505A>G": 1}}	\N
7822419	7815081	c.1201C>T/c.6544A>T	{"RYR1": {"c.1201C>T": 1, "c.6544A>T": 1}}	\N
7822420	7815081	c.1834G>C/c.7043A>G	{"RYR1": {"c.1834G>C": 1, "c.7043A>G": 1}}	\N
7822421	7815081	c.8729C>T/c.14477C>T	{"RYR1": {"c.8729C>T": 1, "c.14477C>T": 1}}	\N
7822422	7815081	c.1597C>T/c.11953T>C	{"RYR1": {"c.1597C>T": 1, "c.11953T>C": 1}}	\N
7822423	7815081	c.742G>C/c.1209C>G	{"RYR1": {"c.742G>C": 1, "c.1209C>G": 1}}	\N
7822424	7815081	c.3166G>C/c.14449A>T	{"RYR1": {"c.3166G>C": 1, "c.14449A>T": 1}}	\N
7822425	7815081	c.5183C>T/c.13760C>T	{"RYR1": {"c.5183C>T": 1, "c.13760C>T": 1}}	\N
7822426	7815081	c.1021G>A/c.14558C>T	{"RYR1": {"c.1021G>A": 1, "c.14558C>T": 1}}	\N
7822427	7815081	c.7018T>C/c.7048G>A	{"RYR1": {"c.7018T>C": 1, "c.7048G>A": 1}}	\N
7822428	7815081	c.7373G>A/c.14197T>G	{"RYR1": {"c.7373G>A": 1, "c.14197T>G": 1}}	\N
7822429	7815081	c.1597C>T/c.11126C>T	{"RYR1": {"c.1597C>T": 1, "c.11126C>T": 1}}	\N
7822430	7815081	c.1654C>T/c.10556C>T	{"RYR1": {"c.1654C>T": 1, "c.10556C>T": 1}}	\N
7822431	7815081	c.178G>A/c.7043A>G	{"RYR1": {"c.178G>A": 1, "c.7043A>G": 1}}	\N
7822432	7815081	c.496G>A/c.7282G>A	{"RYR1": {"c.496G>A": 1, "c.7282G>A": 1}}	\N
7822433	7815081	c.7304G>A/c.14270G>A	{"RYR1": {"c.7304G>A": 1, "c.14270G>A": 1}}	\N
7822434	7815081	c.2122G>A/c.7879G>C	{"RYR1": {"c.2122G>A": 1, "c.7879G>C": 1}}	\N
7822435	7815081	c.742G>A/c.14186A>C	{"RYR1": {"c.742G>A": 1, "c.14186A>C": 1}}	\N
7822436	7815081	c.7358T>C/c.14387A>G	{"RYR1": {"c.7358T>C": 1, "c.14387A>G": 1}}	\N
7822437	7815081	c.1630G>T/c.14581C>T	{"RYR1": {"c.1630G>T": 1, "c.14581C>T": 1}}	\N
7822438	7815081	c.190T>C/c.11708G>A	{"RYR1": {"c.190T>C": 1, "c.11708G>A": 1}}	\N
7822439	7815081	c.11969G>T/c.12028G>A	{"RYR1": {"c.11969G>T": 1, "c.12028G>A": 1}}	\N
7822440	7815081	c.103T>C/c.12553G>A	{"RYR1": {"c.103T>C": 1, "c.12553G>A": 1}}	\N
7822441	7815081	c.5033A>G/c.6612C>G	{"RYR1": {"c.5033A>G": 1, "c.6612C>G": 1}}	\N
7822442	7815081	c.1597C>A/c.6617C>T	{"RYR1": {"c.1597C>A": 1, "c.6617C>T": 1}}	\N
7822443	7815081	c.190T>C/c.1630G>T	{"RYR1": {"c.190T>C": 1, "c.1630G>T": 1}}	\N
7822444	7815081	c.3172G>A/c.7522C>T	{"RYR1": {"c.3172G>A": 1, "c.7522C>T": 1}}	\N
7822445	7815081	c.38T>G/c.10042C>T	{"RYR1": {"c.38T>G": 1, "c.10042C>T": 1}}	\N
7822446	7815081	c.6487C>T/c.12383C>T	{"RYR1": {"c.6487C>T": 1, "c.12383C>T": 1}}	\N
7822447	7815081	c.3418C>T/c.14918C>T	{"RYR1": {"c.3418C>T": 1, "c.14918C>T": 1}}	\N
7822448	7815081	c.7035C>A/c.12064A>G	{"RYR1": {"c.7035C>A": 1, "c.12064A>G": 1}}	\N
7822449	7815081	c.190T>C/c.12149C>A	{"RYR1": {"c.190T>C": 1, "c.12149C>A": 1}}	\N
7822450	7815081	c.1021G>C/c.14509C>G	{"RYR1": {"c.1021G>C": 1, "c.14509C>G": 1}}	\N
7822451	7815081	c.5183C>T/c.6377G>A	{"RYR1": {"c.5183C>T": 1, "c.6377G>A": 1}}	\N
7822452	7815081	c.7085A>G/c.9310G>A	{"RYR1": {"c.7085A>G": 1, "c.9310G>A": 1}}	\N
7822453	7815081	c.1021G>C/c.10252A>G	{"RYR1": {"c.1021G>C": 1, "c.10252A>G": 1}}	\N
7822454	7815081	c.1630G>T/c.3418C>T	{"RYR1": {"c.1630G>T": 1, "c.3418C>T": 1}}	\N
7822455	7815081	c.130C>T/c.14126C>T	{"RYR1": {"c.130C>T": 1, "c.14126C>T": 1}}	\N
7822456	7815081	c.625G>A/c.1021G>C	{"RYR1": {"c.625G>A": 1, "c.1021G>C": 1}}	\N
7822457	7815081	c.7042_7044delGAG/c.7317G>C	{"RYR1": {"c.7317G>C": 1, "c.7042_7044delGAG": 1}}	\N
7822458	7815081	c.742G>A/c.2654G>A	{"RYR1": {"c.742G>A": 1, "c.2654G>A": 1}}	\N
7822459	7815081	c.1597C>A/c.6617C>G	{"RYR1": {"c.1597C>A": 1, "c.6617C>G": 1}}	\N
7822460	7815081	c.7879G>C/c.10252A>G	{"RYR1": {"c.7879G>C": 1, "c.10252A>G": 1}}	\N
7822461	7815081	c.7076G>A/c.8926C>T	{"RYR1": {"c.7076G>A": 1, "c.8926C>T": 1}}	\N
7822462	7815081	c.1630G>T/c.14422_14423delinsAA	{"RYR1": {"c.1630G>T": 1, "c.14422_14423delinsAA": 1}}	\N
7822463	7815081	c.625G>A/c.1021G>A	{"RYR1": {"c.625G>A": 1, "c.1021G>A": 1}}	\N
7822464	7815081	c.13673G>A/c.14210G>A	{"RYR1": {"c.13673G>A": 1, "c.14210G>A": 1}}	\N
7822465	7815081	c.4775C>T/c.14477C>T	{"RYR1": {"c.4775C>T": 1, "c.14477C>T": 1}}	\N
7822466	7815081	c.497A>G/c.7291G>A	{"RYR1": {"c.497A>G": 1, "c.7291G>A": 1}}	\N
7822467	7815081	c.6488G>C/c.7528T>C	{"RYR1": {"c.6488G>C": 1, "c.7528T>C": 1}}	\N
7822468	7815081	c.5183C>T/c.12398A>G	{"RYR1": {"c.5183C>T": 1, "c.12398A>G": 1}}	\N
7822469	7815081	c.7360C>T/c.13994_13995delTCinsCT	{"RYR1": {"c.7360C>T": 1, "c.13994_13995delTCinsCT": 1}}	\N
7822470	7815081	c.3527C>T/c.7310C>T	{"RYR1": {"c.3527C>T": 1, "c.7310C>T": 1}}	\N
7822471	7815081	c.1589G>A/c.14186A>C	{"RYR1": {"c.1589G>A": 1, "c.14186A>C": 1}}	\N
7822472	7815081	c.12149C>A/c.14581C>T	{"RYR1": {"c.12149C>A": 1, "c.14581C>T": 1}}	\N
7822473	7815081	c.1021G>C/c.14558C>T	{"RYR1": {"c.1021G>C": 1, "c.14558C>T": 1}}	\N
7822474	7815081	c.7036G>A/c.7099G>A	{"RYR1": {"c.7036G>A": 1, "c.7099G>A": 1}}	\N
7822475	7815081	c.641C>T/c.7035C>A	{"RYR1": {"c.641C>T": 1, "c.7035C>A": 1}}	\N
7822476	7815081	c.463C>A/c.2924G>A	{"RYR1": {"c.463C>A": 1, "c.2924G>A": 1}}	\N
7822477	7815081	c.982C>T/c.9758T>C	{"RYR1": {"c.982C>T": 1, "c.9758T>C": 1}}	\N
7822478	7815081	c.38T>G/c.992_994dup	{"RYR1": {"c.38T>G": 1, "c.992_994dup": 1}}	\N
7822479	7815081	c.479A>G/c.5183C>T	{"RYR1": {"c.479A>G": 1, "c.5183C>T": 1}}	\N
7822480	7815081	c.497A>G/c.7291G>T	{"RYR1": {"c.497A>G": 1, "c.7291G>T": 1}}	\N
7822481	7815081	c.467G>A/c.8026C>T	{"RYR1": {"c.467G>A": 1, "c.8026C>T": 1}}	\N
7822482	7815081	c.3656A>C/c.7043A>G	{"RYR1": {"c.3656A>C": 1, "c.7043A>G": 1}}	\N
7822483	7815081	c.14545G>A/c.14813T>C	{"RYR1": {"c.14545G>A": 1, "c.14813T>C": 1}}	\N
7822484	7815081	c.103T>C/c.14639T>C	{"RYR1": {"c.103T>C": 1, "c.14639T>C": 1}}	\N
7822485	7815081	c.1021G>A/c.14509C>G	{"RYR1": {"c.1021G>A": 1, "c.14509C>G": 1}}	\N
7822486	7815081	c.6488G>T/c.11947C>T	{"RYR1": {"c.6488G>T": 1, "c.11947C>T": 1}}	\N
7822487	7815081	c.7075C>T/c.7304G>A	{"RYR1": {"c.7075C>T": 1, "c.7304G>A": 1}}	\N
7822488	7815081	c.11748T>G/c.14539G>C	{"RYR1": {"c.11748T>G": 1, "c.14539G>C": 1}}	\N
7822489	7815081	c.1615T>G/c.13673G>A	{"RYR1": {"c.1615T>G": 1, "c.13673G>A": 1}}	\N
7822490	7815081	c.103T>C/c.2654G>A	{"RYR1": {"c.103T>C": 1, "c.2654G>A": 1}}	\N
7822491	7815081	c.11416G>A/c.14477C>T	{"RYR1": {"c.11416G>A": 1, "c.14477C>T": 1}}	\N
7822492	7815081	c.463C>A/c.6304G>C	{"RYR1": {"c.463C>A": 1, "c.6304G>C": 1}}	\N
7822493	7815081	c.7035C>A/c.11416G>A	{"RYR1": {"c.7035C>A": 1, "c.11416G>A": 1}}	\N
7822494	7815081	c.1021G>A/c.10252A>G	{"RYR1": {"c.1021G>A": 1, "c.10252A>G": 1}}	\N
7822495	7815081	c.488G>T/c.12121C>T	{"RYR1": {"c.488G>T": 1, "c.12121C>T": 1}}	\N
7822496	7815081	c.6388G>A/c.7522C>T	{"RYR1": {"c.6388G>A": 1, "c.7522C>T": 1}}	\N
7822497	7815081	c.7879G>C/c.12355A>T	{"RYR1": {"c.7879G>C": 1, "c.12355A>T": 1}}	\N
7822498	7815081	c.1201C>G/c.14497C>T	{"RYR1": {"c.1201C>G": 1, "c.14497C>T": 1}}	\N
7822499	7815081	c.529C>T/c.14813T>C	{"RYR1": {"c.529C>T": 1, "c.14813T>C": 1}}	\N
7822500	7815081	c.6742C>T/c.6838G>A	{"RYR1": {"c.6742C>T": 1, "c.6838G>A": 1}}	\N
7822501	7815081	c.7042_7044delGAG/c.14678G>A	{"RYR1": {"c.14678G>A": 1, "c.7042_7044delGAG": 1}}	\N
7822502	7815081	c.12848A>T/c.14210G>A	{"RYR1": {"c.12848A>T": 1, "c.14210G>A": 1}}	\N
7822503	7815081	c.6710G>A/c.14512C>G	{"RYR1": {"c.6710G>A": 1, "c.14512C>G": 1}}	\N
7822504	7815081	c.38T>G/c.533A>C	{"RYR1": {"c.38T>G": 1, "c.533A>C": 1}}	\N
7822505	7815081	c.5183C>T/c.11813G>A	{"RYR1": {"c.5183C>T": 1, "c.11813G>A": 1}}	\N
7822506	7815081	c.742G>C/c.2654G>A	{"RYR1": {"c.742G>C": 1, "c.2654G>A": 1}}	\N
7822507	7815081	c.7075C>T/c.7304G>T	{"RYR1": {"c.7075C>T": 1, "c.7304G>T": 1}}	\N
7822508	7815081	c.11969G>T/c.14680G>A	{"RYR1": {"c.11969G>T": 1, "c.14680G>A": 1}}	\N
7822509	7815081	c.1589G>A/c.2654G>A	{"RYR1": {"c.1589G>A": 1, "c.2654G>A": 1}}	\N
7822510	7815081	c.12149C>A/c.12848A>T	{"RYR1": {"c.12149C>A": 1, "c.12848A>T": 1}}	\N
7822511	7815081	c.130C>T/c.14814C>G	{"RYR1": {"c.130C>T": 1, "c.14814C>G": 1}}	\N
7822512	7815081	c.6488G>A/c.7528T>C	{"RYR1": {"c.6488G>A": 1, "c.7528T>C": 1}}	\N
7822513	7815081	c.7084G>A/c.14424C>A	{"RYR1": {"c.7084G>A": 1, "c.14424C>A": 1}}	\N
7822514	7815081	c.7060G>A/c.7097C>G	{"RYR1": {"c.7060G>A": 1, "c.7097C>G": 1}}	\N
7822515	7815081	c.1202G>T/c.6388G>A	{"RYR1": {"c.1202G>T": 1, "c.6388G>A": 1}}	\N
7822516	7815081	c.7361G>A/c.14817C>A	{"RYR1": {"c.7361G>A": 1, "c.14817C>A": 1}}	\N
7822517	7815081	c.6847A>C/c.14497C>T	{"RYR1": {"c.6847A>C": 1, "c.14497C>T": 1}}	\N
7822518	7815081	c.6612C>G/c.14424C>A	{"RYR1": {"c.6612C>G": 1, "c.14424C>A": 1}}	\N
7822519	7815081	c.152C>A/c.14209C>T	{"RYR1": {"c.152C>A": 1, "c.14209C>T": 1}}	\N
7822520	7815081	c.463C>A/c.12532G>A	{"RYR1": {"c.463C>A": 1, "c.12532G>A": 1}}	\N
7822521	7815081	c.1841G>T/c.7097C>G	{"RYR1": {"c.1841G>T": 1, "c.7097C>G": 1}}	\N
7822522	7815081	c.7042_7044delGAG/c.9850T>A	{"RYR1": {"c.9850T>A": 1, "c.7042_7044delGAG": 1}}	\N
7822523	7815081	c.6488G>T/c.14449A>T	{"RYR1": {"c.6488G>T": 1, "c.14449A>T": 1}}	\N
7822524	7815081	c.982C>T/c.10750G>C	{"RYR1": {"c.982C>T": 1, "c.10750G>C": 1}}	\N
7822525	7815081	c.1422G>T/c.7123G>A	{"RYR1": {"c.1422G>T": 1, "c.7123G>A": 1}}	\N
7822526	7815081	c.14512C>G/c.14639T>C	{"RYR1": {"c.14512C>G": 1, "c.14639T>C": 1}}	\N
7822527	7815081	c.529C>T/c.12064A>G	{"RYR1": {"c.529C>T": 1, "c.12064A>G": 1}}	\N
7822528	7815081	c.1459C>G/c.7084G>A	{"RYR1": {"c.1459C>G": 1, "c.7084G>A": 1}}	\N
7822529	7815081	c.1100G>T/c.7879G>C	{"RYR1": {"c.1100G>T": 1, "c.7879G>C": 1}}	\N
7822530	7815081	c.488G>T/c.7385C>T	{"RYR1": {"c.488G>T": 1, "c.7385C>T": 1}}	\N
7822531	7815081	c.6847A>C/c.12149C>A	{"RYR1": {"c.6847A>C": 1, "c.12149C>A": 1}}	\N
7822532	7815081	c.1201C>T/c.3166G>A	{"RYR1": {"c.1201C>T": 1, "c.3166G>A": 1}}	\N
7822533	7815081	c.6488G>T/c.14387A>G	{"RYR1": {"c.6488G>T": 1, "c.14387A>G": 1}}	\N
7822534	7815081	c.6617C>T/c.12848A>T	{"RYR1": {"c.6617C>T": 1, "c.12848A>T": 1}}	\N
7822535	7815081	c.1597C>T/c.11748T>G	{"RYR1": {"c.1597C>T": 1, "c.11748T>G": 1}}	\N
7822536	7815081	c.7076G>A/c.12532G>A	{"RYR1": {"c.7076G>A": 1, "c.12532G>A": 1}}	\N
7822537	7815081	c.6377G>A/c.7042_7044delGAG	{"RYR1": {"c.6377G>A": 1, "c.7042_7044delGAG": 1}}	\N
7822538	7815081	c.3166G>A/c.6502G>A	{"RYR1": {"c.3166G>A": 1, "c.6502G>A": 1}}	\N
7822539	7815081	c.7042_7044delGAG/c.14270G>A	{"RYR1": {"c.14270G>A": 1, "c.7042_7044delGAG": 1}}	\N
7822540	7815081	c.533A>C/c.6628G>T	{"RYR1": {"c.533A>C": 1, "c.6628G>T": 1}}	\N
7822541	7815081	c.5183C>T/c.7097C>G	{"RYR1": {"c.5183C>T": 1, "c.7097C>G": 1}}	\N
7822542	7815081	c.38T>G/c.8638G>A	{"RYR1": {"c.38T>G": 1, "c.8638G>A": 1}}	\N
7822543	7815081	c.6599C>T/c.7007G>A	{"RYR1": {"c.6599C>T": 1, "c.7007G>A": 1}}	\N
7822544	7815081	c.7300G>A/c.12115A>T	{"RYR1": {"c.7300G>A": 1, "c.12115A>T": 1}}	\N
7822545	7815081	c.1615T>G/c.11132C>T	{"RYR1": {"c.1615T>G": 1, "c.11132C>T": 1}}	\N
7822546	7815081	c.677T>A/c.6612C>G	{"RYR1": {"c.677T>A": 1, "c.6612C>G": 1}}	\N
7822547	7815081	c.7073T>A/c.7358T>C	{"RYR1": {"c.7073T>A": 1, "c.7358T>C": 1}}	\N
7822548	7815081	c.1630G>T/c.10237A>T	{"RYR1": {"c.1630G>T": 1, "c.10237A>T": 1}}	\N
7822549	7815081	c.7043A>G/c.7879G>A	{"RYR1": {"c.7043A>G": 1, "c.7879G>A": 1}}	\N
7822550	7815081	c.1021G>C/c.14449A>T	{"RYR1": {"c.1021G>C": 1, "c.14449A>T": 1}}	\N
7822551	7815081	c.1598G>A/c.14545G>A	{"RYR1": {"c.1598G>A": 1, "c.14545G>A": 1}}	\N
7822552	7815081	c.680A>T/c.7360C>T	{"RYR1": {"c.680A>T": 1, "c.7360C>T": 1}}	\N
7822553	7815081	c.2537C>T/c.7063C>T	{"RYR1": {"c.2537C>T": 1, "c.7063C>T": 1}}	\N
7822554	7815081	c.1201C>T/c.5024T>C	{"RYR1": {"c.1201C>T": 1, "c.5024T>C": 1}}	\N
7822555	7815081	c.6488G>A/c.9652G>A	{"RYR1": {"c.6488G>A": 1, "c.9652G>A": 1}}	\N
7822556	7815081	c.6617C>G/c.11947C>T	{"RYR1": {"c.6617C>G": 1, "c.11947C>T": 1}}	\N
7822557	7815081	c.13934G>A/c.14209C>T	{"RYR1": {"c.13934G>A": 1, "c.14209C>T": 1}}	\N
7822558	7815081	c.1144C>A/c.7310C>T	{"RYR1": {"c.1144C>A": 1, "c.7310C>T": 1}}	\N
7822559	7815081	c.7124G>C/c.14818G>A	{"RYR1": {"c.7124G>C": 1, "c.14818G>A": 1}}	\N
7822560	7815081	c.6838G>A/c.14581C>T	{"RYR1": {"c.6838G>A": 1, "c.14581C>T": 1}}	\N
7822561	7815081	c.14270G>A/c.14477C>T	{"RYR1": {"c.14270G>A": 1, "c.14477C>T": 1}}	\N
7822562	7815081	c.1615T>C/c.13673G>A	{"RYR1": {"c.1615T>C": 1, "c.13673G>A": 1}}	\N
7822563	7815081	c.1201C>A/c.1565A>G	{"RYR1": {"c.1201C>A": 1, "c.1565A>G": 1}}	\N
7822564	7815081	c.9652G>A/c.11708G>A	{"RYR1": {"c.9652G>A": 1, "c.11708G>A": 1}}	\N
7822565	7815081	c.1201C>A/c.1565A>C	{"RYR1": {"c.1201C>A": 1, "c.1565A>C": 1}}	\N
7822566	7815081	c.6612C>G/c.7778G>A	{"RYR1": {"c.6612C>G": 1, "c.7778G>A": 1}}	\N
7822567	7815081	c.7361G>A/c.14782A>G	{"RYR1": {"c.7361G>A": 1, "c.14782A>G": 1}}	\N
7822568	7815081	c.3166G>A/c.14918C>T	{"RYR1": {"c.3166G>A": 1, "c.14918C>T": 1}}	\N
7822569	7815081	c.7304G>A/c.7317G>C	{"RYR1": {"c.7304G>A": 1, "c.7317G>C": 1}}	\N
7822570	7815081	c.11947C>T/c.12700G>C	{"RYR1": {"c.11947C>T": 1, "c.12700G>C": 1}}	\N
7822571	7815081	c.7060G>A/c.9868G>A	{"RYR1": {"c.7060G>A": 1, "c.9868G>A": 1}}	\N
7822572	7815081	c.7032G>C/c.11708G>A	{"RYR1": {"c.7032G>C": 1, "c.11708G>A": 1}}	\N
7822573	7815081	c.3166G>C/c.6743G>A	{"RYR1": {"c.3166G>C": 1, "c.6743G>A": 1}}	\N
7822574	7815081	c.7048G>A/c.8518C>T	{"RYR1": {"c.7048G>A": 1, "c.8518C>T": 1}}	\N
7822575	7815081	c.7035C>A/c.14002C>T	{"RYR1": {"c.7035C>A": 1, "c.14002C>T": 1}}	\N
7822576	7815081	c.7007G>A/c.10042C>T	{"RYR1": {"c.7007G>A": 1, "c.10042C>T": 1}}	\N
7822577	7815081	c.7360C>T/c.14582G>A	{"RYR1": {"c.7360C>T": 1, "c.14582G>A": 1}}	\N
7822578	7815081	c.1565A>C/c.7760A>G	{"RYR1": {"c.1565A>C": 1, "c.7760A>G": 1}}	\N
7822579	7815081	c.1597C>A/c.7063C>T	{"RYR1": {"c.1597C>A": 1, "c.7063C>T": 1}}	\N
7822580	7815081	c.742G>A/c.7032G>C	{"RYR1": {"c.742G>A": 1, "c.7032G>C": 1}}	\N
7822581	7815081	c.6478G>A/c.7042_7044delGAG	{"RYR1": {"c.6478G>A": 1, "c.7042_7044delGAG": 1}}	\N
7822582	7815081	c.488G>T/c.8638G>A	{"RYR1": {"c.488G>T": 1, "c.8638G>A": 1}}	\N
7822583	7815081	c.1589G>A/c.12553G>A	{"RYR1": {"c.1589G>A": 1, "c.12553G>A": 1}}	\N
7822584	7815081	c.1201C>T/c.6847A>C	{"RYR1": {"c.1201C>T": 1, "c.6847A>C": 1}}	\N
7822585	7815081	c.7063C>T/c.10043G>A	{"RYR1": {"c.7063C>T": 1, "c.10043G>A": 1}}	\N
7822586	7815081	c.1021G>C/c.2050G>C	{"RYR1": {"c.1021G>C": 1, "c.2050G>C": 1}}	\N
7822587	7815081	c.1021G>A/c.14449A>T	{"RYR1": {"c.1021G>A": 1, "c.14449A>T": 1}}	\N
7822588	7815081	c.38T>G/c.2537C>T	{"RYR1": {"c.38T>G": 1, "c.2537C>T": 1}}	\N
7822589	7815081	c.4763C>T/c.14512C>G	{"RYR1": {"c.4763C>T": 1, "c.14512C>G": 1}}	\N
7822590	7815081	c.2924G>A/c.14545G>A	{"RYR1": {"c.2924G>A": 1, "c.14545G>A": 1}}	\N
7822591	7815081	c.7007G>A/c.11126C>T	{"RYR1": {"c.7007G>A": 1, "c.11126C>T": 1}}	\N
7822592	7815081	c.6488G>C/c.9652G>A	{"RYR1": {"c.6488G>C": 1, "c.9652G>A": 1}}	\N
7822593	7815081	c.7300G>A/c.14126C>T	{"RYR1": {"c.7300G>A": 1, "c.14126C>T": 1}}	\N
7822594	7815081	c.6612C>G/c.7210G>A	{"RYR1": {"c.6612C>G": 1, "c.7210G>A": 1}}	\N
7822595	7815081	c.488G>T/c.8189A>G	{"RYR1": {"c.488G>T": 1, "c.8189A>G": 1}}	\N
7822596	7815081	c.11947C>T/c.12700G>T	{"RYR1": {"c.11947C>T": 1, "c.12700G>T": 1}}	\N
7822597	7815081	c.7304G>A/c.14581C>T	{"RYR1": {"c.7304G>A": 1, "c.14581C>T": 1}}	\N
7822598	7815081	c.1460T>C/c.14209C>T	{"RYR1": {"c.1460T>C": 1, "c.14209C>T": 1}}	\N
7822599	7815081	c.467G>A/c.742G>A	{"RYR1": {"c.467G>A": 1, "c.742G>A": 1}}	\N
7822600	7815081	c.3172G>A/c.6838G>A	{"RYR1": {"c.3172G>A": 1, "c.6838G>A": 1}}	\N
7822601	7815081	c.467G>A/c.742G>C	{"RYR1": {"c.467G>A": 1, "c.742G>C": 1}}	\N
7822602	7815081	c.6502G>A/c.8198G>A	{"RYR1": {"c.6502G>A": 1, "c.8198G>A": 1}}	\N
7822603	7815081	c.7361G>A/c.7771C>G	{"RYR1": {"c.7361G>A": 1, "c.7771C>G": 1}}	\N
7822604	7815081	c.3127C>T/c.14497C>T	{"RYR1": {"c.3127C>T": 1, "c.14497C>T": 1}}	\N
7822605	7815081	c.1100G>A/c.6349G>C	{"RYR1": {"c.1100G>A": 1, "c.6349G>C": 1}}	\N
7822606	7815081	c.6349G>C/c.9356G>A	{"RYR1": {"c.6349G>C": 1, "c.9356G>A": 1}}	\N
7822607	7815081	c.7361G>A/c.7771C>T	{"RYR1": {"c.7361G>A": 1, "c.7771C>T": 1}}	\N
7822608	7815081	c.7304G>A/c.14678G>A	{"RYR1": {"c.7304G>A": 1, "c.14678G>A": 1}}	\N
7822609	7815081	c.7304G>A/c.9850T>A	{"RYR1": {"c.7304G>A": 1, "c.9850T>A": 1}}	\N
7822610	7815081	c.6502G>A/c.7307G>A	{"RYR1": {"c.6502G>A": 1, "c.7307G>A": 1}}	\N
7822611	7815081	c.7199A>G/c.7358T>C	{"RYR1": {"c.7199A>G": 1, "c.7358T>C": 1}}	\N
7822612	7815081	c.1589G>A/c.5186T>G	{"RYR1": {"c.1589G>A": 1, "c.5186T>G": 1}}	\N
7822613	7815081	c.1553T>C/c.6617C>T	{"RYR1": {"c.1553T>C": 1, "c.6617C>T": 1}}	\N
7822614	7815081	c.497A>G/c.6628G>T	{"RYR1": {"c.497A>G": 1, "c.6628G>T": 1}}	\N
7822615	7815081	c.488G>T/c.992_994dup	{"RYR1": {"c.488G>T": 1, "c.992_994dup": 1}}	\N
7822616	7815081	c.5183C>T/c.12242C>T	{"RYR1": {"c.5183C>T": 1, "c.12242C>T": 1}}	\N
7822617	7815081	c.625G>A/c.7035C>A	{"RYR1": {"c.625G>A": 1, "c.7035C>A": 1}}	\N
7822618	7815081	c.1597C>T/c.7487C>T	{"RYR1": {"c.1597C>T": 1, "c.7487C>T": 1}}	\N
7822619	7815081	c.6488G>A/c.9676G>C	{"RYR1": {"c.6488G>A": 1, "c.9676G>C": 1}}	\N
7822620	7815081	c.8026C>T/c.15060G>C	{"RYR1": {"c.8026C>T": 1, "c.15060G>C": 1}}	\N
7822621	7815081	c.7007G>A/c.11953T>C	{"RYR1": {"c.7007G>A": 1, "c.11953T>C": 1}}	\N
7822622	7815081	c.1553T>C/c.6617C>G	{"RYR1": {"c.1553T>C": 1, "c.6617C>G": 1}}	\N
7822623	7815081	c.742G>C/c.7032G>C	{"RYR1": {"c.742G>C": 1, "c.7032G>C": 1}}	\N
7822624	7815081	c.1565A>C/c.7385C>T	{"RYR1": {"c.1565A>C": 1, "c.7385C>T": 1}}	\N
7822625	7815081	c.7035C>A/c.9676G>C	{"RYR1": {"c.7035C>A": 1, "c.9676G>C": 1}}	\N
7822626	7815081	c.1615T>C/c.14471T>C	{"RYR1": {"c.1615T>C": 1, "c.14471T>C": 1}}	\N
7822627	7815081	c.6488G>C/c.14002C>T	{"RYR1": {"c.6488G>C": 1, "c.14002C>T": 1}}	\N
7822628	7815081	c.1021G>A/c.2050G>C	{"RYR1": {"c.1021G>A": 1, "c.2050G>C": 1}}	\N
7822629	7815081	c.6488G>C/c.8198G>A	{"RYR1": {"c.6488G>C": 1, "c.8198G>A": 1}}	\N
7822630	7815081	c.6612C>G/c.14825G>T	{"RYR1": {"c.6612C>G": 1, "c.14825G>T": 1}}	\N
7822631	7815081	c.103T>C/c.5186T>G	{"RYR1": {"c.103T>C": 1, "c.5186T>G": 1}}	\N
7822632	7815081	c.497A>G/c.5183C>T	{"RYR1": {"c.497A>G": 1, "c.5183C>T": 1}}	\N
7822633	7815081	c.6488G>T/c.7292A>T	{"RYR1": {"c.6488G>T": 1, "c.7292A>T": 1}}	\N
7822634	7815081	c.4400A>G/c.7042_7044delGAG	{"RYR1": {"c.4400A>G": 1, "c.7042_7044delGAG": 1}}	\N
7822635	7815081	c.1459C>G/c.7060G>A	{"RYR1": {"c.1459C>G": 1, "c.7060G>A": 1}}	\N
7822636	7815081	c.7317G>C/c.14209C>T	{"RYR1": {"c.7317G>C": 1, "c.14209C>T": 1}}	\N
7822637	7815081	c.1597C>A/c.6838G>A	{"RYR1": {"c.1597C>A": 1, "c.6838G>A": 1}}	\N
7822638	7815081	c.533A>C/c.7291G>T	{"RYR1": {"c.533A>C": 1, "c.7291G>T": 1}}	\N
7822639	7815081	c.528G>T/c.1654C>T	{"RYR1": {"c.528G>T": 1, "c.1654C>T": 1}}	\N
7822640	7815081	c.946C>T/c.6502G>A	{"RYR1": {"c.946C>T": 1, "c.6502G>A": 1}}	\N
7822641	7815081	c.7018T>C/c.7036G>A	{"RYR1": {"c.7018T>C": 1, "c.7036G>A": 1}}	\N
7822642	7815081	c.97A>G/c.14817C>A	{"RYR1": {"c.97A>G": 1, "c.14817C>A": 1}}	\N
7822643	7815081	c.1841G>T/c.5441T>A	{"RYR1": {"c.1841G>T": 1, "c.5441T>A": 1}}	\N
7822644	7815081	c.9676G>C/c.14210G>A	{"RYR1": {"c.9676G>C": 1, "c.14210G>A": 1}}	\N
7822645	7815081	c.529C>T/c.9868G>A	{"RYR1": {"c.529C>T": 1, "c.9868G>A": 1}}	\N
7822646	7815081	c.533A>C/c.7291G>A	{"RYR1": {"c.533A>C": 1, "c.7291G>A": 1}}	\N
7822647	7815081	c.3166G>C/c.10252A>G	{"RYR1": {"c.3166G>C": 1, "c.10252A>G": 1}}	\N
7822648	7815081	c.2122G>A/c.6349G>C	{"RYR1": {"c.2122G>A": 1, "c.6349G>C": 1}}	\N
7822649	7815081	c.103T>C/c.1100G>T	{"RYR1": {"c.103T>C": 1, "c.1100G>T": 1}}	\N
7822650	7815081	c.7123G>A/c.9152G>A	{"RYR1": {"c.7123G>A": 1, "c.9152G>A": 1}}	\N
7822651	7815081	c.6488G>C/c.9676G>C	{"RYR1": {"c.6488G>C": 1, "c.9676G>C": 1}}	\N
7822652	7815081	c.7060G>A/c.11813G>A	{"RYR1": {"c.7060G>A": 1, "c.11813G>A": 1}}	\N
7822653	7815081	c.982C>T/c.13913G>A	{"RYR1": {"c.982C>T": 1, "c.13913G>A": 1}}	\N
7822654	7815081	c.10043G>A/c.14477C>T	{"RYR1": {"c.10043G>A": 1, "c.14477C>T": 1}}	\N
7822655	7815081	c.488G>T/c.7760A>G	{"RYR1": {"c.488G>T": 1, "c.7760A>G": 1}}	\N
7822656	7815081	c.1565A>C/c.13505A>G	{"RYR1": {"c.1565A>C": 1, "c.13505A>G": 1}}	\N
7822657	7815081	c.6488G>A/c.7487C>T	{"RYR1": {"c.6488G>A": 1, "c.7487C>T": 1}}	\N
7822658	7815081	c.641C>T/c.1021G>C	{"RYR1": {"c.641C>T": 1, "c.1021G>C": 1}}	\N
7822659	7815081	c.8026C>T/c.15059G>C	{"RYR1": {"c.8026C>T": 1, "c.15059G>C": 1}}	\N
7822660	7815081	c.7304G>A/c.13702C>G	{"RYR1": {"c.7304G>A": 1, "c.13702C>G": 1}}	\N
7822661	7815081	c.641C>T/c.1021G>A	{"RYR1": {"c.641C>T": 1, "c.1021G>A": 1}}	\N
7822662	7815081	c.742G>C/c.6710G>A	{"RYR1": {"c.742G>C": 1, "c.6710G>A": 1}}	\N
7822663	7815081	c.6548G>A/c.11708G>A	{"RYR1": {"c.6548G>A": 1, "c.11708G>A": 1}}	\N
7822664	7815081	c.7060G>A/c.11416G>A	{"RYR1": {"c.7060G>A": 1, "c.11416G>A": 1}}	\N
7822665	7815081	c.6743G>A/c.14918C>T	{"RYR1": {"c.6743G>A": 1, "c.14918C>T": 1}}	\N
7822666	7815081	c.742G>A/c.6710G>A	{"RYR1": {"c.742G>A": 1, "c.6710G>A": 1}}	\N
7822667	7815081	c.103T>C/c.1100G>A	{"RYR1": {"c.103T>C": 1, "c.1100G>A": 1}}	\N
7822668	7815081	c.7036G>A/c.9635A>G	{"RYR1": {"c.7036G>A": 1, "c.9635A>G": 1}}	\N
7822669	7815081	c.7300G>A/c.7778G>A	{"RYR1": {"c.7300G>A": 1, "c.7778G>A": 1}}	\N
7822670	7815081	c.529C>T/c.7760A>G	{"RYR1": {"c.529C>T": 1, "c.7760A>G": 1}}	\N
7822671	7815081	c.6488G>A/c.14002C>T	{"RYR1": {"c.6488G>A": 1, "c.14002C>T": 1}}	\N
7822672	7815081	c.7076G>A/c.12398A>G	{"RYR1": {"c.7076G>A": 1, "c.12398A>G": 1}}	\N
7822673	7815081	c.6488G>A/c.8198G>A	{"RYR1": {"c.6488G>A": 1, "c.8198G>A": 1}}	\N
7822674	7815081	c.488G>T/c.10042C>T	{"RYR1": {"c.488G>T": 1, "c.10042C>T": 1}}	\N
7822675	7815081	c.130C>T/c.3667G>A	{"RYR1": {"c.130C>T": 1, "c.3667G>A": 1}}	\N
7822676	7815081	c.6488G>C/c.14558C>T	{"RYR1": {"c.6488G>C": 1, "c.14558C>T": 1}}	\N
7822677	7815081	c.1202G>A/c.12028G>A	{"RYR1": {"c.1202G>A": 1, "c.12028G>A": 1}}	\N
7822678	7815081	c.1209C>G/c.14539G>C	{"RYR1": {"c.1209C>G": 1, "c.14539G>C": 1}}	\N
7822679	7815081	c.3166G>C/c.14509C>G	{"RYR1": {"c.3166G>C": 1, "c.14509C>G": 1}}	\N
7822680	7815081	c.680A>T/c.7372C>T	{"RYR1": {"c.680A>T": 1, "c.7372C>T": 1}}	\N
7822681	7815081	c.6387C>G/c.9499C>T	{"RYR1": {"c.6387C>G": 1, "c.9499C>T": 1}}	\N
7822682	7815081	c.8026C>T/c.14818G>A	{"RYR1": {"c.8026C>T": 1, "c.14818G>A": 1}}	\N
7822683	7815081	c.38T>G/c.14813T>C	{"RYR1": {"c.38T>G": 1, "c.14813T>C": 1}}	\N
7822684	7815081	c.487C>T/c.497A>G	{"RYR1": {"c.487C>T": 1, "c.497A>G": 1}}	\N
7822685	7815081	c.7042_7044delGAG/c.10237A>T	{"RYR1": {"c.10237A>T": 1, "c.7042_7044delGAG": 1}}	\N
7822686	7815081	c.7358T>C/c.9652G>A	{"RYR1": {"c.7358T>C": 1, "c.9652G>A": 1}}	\N
7822687	7815081	c.51_53del/c.742G>A	{"RYR1": {"c.742G>A": 1, "c.51_53del": 1}}	\N
7822688	7815081	c.51_53del/c.742G>C	{"RYR1": {"c.742G>C": 1, "c.51_53del": 1}}	\N
7822689	7815081	c.1021G>A/c.1459C>G	{"RYR1": {"c.1021G>A": 1, "c.1459C>G": 1}}	\N
7822690	7815081	c.1615T>C/c.14879T>A	{"RYR1": {"c.1615T>C": 1, "c.14879T>A": 1}}	\N
7822691	7815081	c.7076G>A/c.14458G>T	{"RYR1": {"c.7076G>A": 1, "c.14458G>T": 1}}	\N
7822692	7815081	c.7360C>T/c.14581C>T	{"RYR1": {"c.7360C>T": 1, "c.14581C>T": 1}}	\N
7822693	7815081	c.9310G>A/c.12115A>T	{"RYR1": {"c.9310G>A": 1, "c.12115A>T": 1}}	\N
7822694	7815081	c.5341T>C/c.7291G>A	{"RYR1": {"c.5341T>C": 1, "c.7291G>A": 1}}	\N
7822695	7815081	c.97A>G/c.14818G>A	{"RYR1": {"c.97A>G": 1, "c.14818G>A": 1}}	\N
7822696	7815081	c.463C>A/c.1201C>G	{"RYR1": {"c.463C>A": 1, "c.1201C>G": 1}}	\N
7822697	7815081	c.7035C>A/c.14387A>G	{"RYR1": {"c.7035C>A": 1, "c.14387A>G": 1}}	\N
7822698	7815081	c.1840C>T/c.8638G>A	{"RYR1": {"c.1840C>T": 1, "c.8638G>A": 1}}	\N
7822699	7815081	c.6488G>A/c.7292A>T	{"RYR1": {"c.6488G>A": 1, "c.7292A>T": 1}}	\N
7822700	7815081	c.7112A>G/c.14497C>T	{"RYR1": {"c.7112A>G": 1, "c.14497C>T": 1}}	\N
7822701	7815081	c.7292A>T/c.11315G>A	{"RYR1": {"c.7292A>T": 1, "c.11315G>A": 1}}	\N
7822702	7815081	c.1021G>C/c.7487C>T	{"RYR1": {"c.1021G>C": 1, "c.7487C>T": 1}}	\N
7822703	7815081	c.7354C>T/c.9850T>A	{"RYR1": {"c.7354C>T": 1, "c.9850T>A": 1}}	\N
7822704	7815081	c.947G>T/c.11708G>A	{"RYR1": {"c.947G>T": 1, "c.11708G>A": 1}}	\N
7822705	7815081	c.947G>T/c.7358T>C	{"RYR1": {"c.947G>T": 1, "c.7358T>C": 1}}	\N
7822706	7815081	c.178G>T/c.7043A>G	{"RYR1": {"c.178G>T": 1, "c.7043A>G": 1}}	\N
7822707	7815081	c.12398A>G/c.14209C>T	{"RYR1": {"c.12398A>G": 1, "c.14209C>T": 1}}	\N
7822708	7815081	c.1202G>T/c.12028G>A	{"RYR1": {"c.1202G>T": 1, "c.12028G>A": 1}}	\N
7822709	7815081	c.1834G>C/c.7372C>T	{"RYR1": {"c.1834G>C": 1, "c.7372C>T": 1}}	\N
7822710	7815081	c.5024T>C/c.14209C>T	{"RYR1": {"c.5024T>C": 1, "c.14209C>T": 1}}	\N
7822711	7815081	c.9868G>A/c.11969G>T	{"RYR1": {"c.9868G>A": 1, "c.11969G>T": 1}}	\N
7822712	7815081	c.529C>T/c.10042C>T	{"RYR1": {"c.529C>T": 1, "c.10042C>T": 1}}	\N
7822713	7815081	c.463C>A/c.13760C>T	{"RYR1": {"c.463C>A": 1, "c.13760C>T": 1}}	\N
7822714	7815081	c.7007G>A/c.14813T>C	{"RYR1": {"c.7007G>A": 1, "c.14813T>C": 1}}	\N
7822715	7815081	c.1021G>A/c.7307G>A	{"RYR1": {"c.1021G>A": 1, "c.7307G>A": 1}}	\N
7822716	7815081	c.7523G>A/c.14424C>A	{"RYR1": {"c.7523G>A": 1, "c.14424C>A": 1}}	\N
7822717	7815081	c.5890C>T/c.7304G>T	{"RYR1": {"c.5890C>T": 1, "c.7304G>T": 1}}	\N
7822718	7815081	c.1565A>C/c.10042C>T	{"RYR1": {"c.1565A>C": 1, "c.10042C>T": 1}}	\N
7822719	7815081	c.529C>T/c.11416G>A	{"RYR1": {"c.529C>T": 1, "c.11416G>A": 1}}	\N
7822720	7815081	c.680A>T/c.1597C>T	{"RYR1": {"c.680A>T": 1, "c.1597C>T": 1}}	\N
7822721	7815081	c.9676G>C/c.14512C>G	{"RYR1": {"c.9676G>C": 1, "c.14512C>G": 1}}	\N
7822722	7815081	c.1201C>T/c.3527C>T	{"RYR1": {"c.1201C>T": 1, "c.3527C>T": 1}}	\N
7822723	7815081	c.1201C>A/c.14627A>G	{"RYR1": {"c.1201C>A": 1, "c.14627A>G": 1}}	\N
7822724	7815081	c.1630G>T/c.13994_13995delTCinsCT	{"RYR1": {"c.1630G>T": 1, "c.13994_13995delTCinsCT": 1}}	\N
7822725	7815081	c.7036G>A/c.14458G>A	{"RYR1": {"c.7036G>A": 1, "c.14458G>A": 1}}	\N
7822726	7815081	c.103T>C/c.467G>A	{"RYR1": {"c.103T>C": 1, "c.467G>A": 1}}	\N
7822727	7815081	c.7035C>A/c.12355A>T	{"RYR1": {"c.7035C>A": 1, "c.12355A>T": 1}}	\N
7822728	7815081	c.7300G>A/c.8654C>G	{"RYR1": {"c.7300G>A": 1, "c.8654C>G": 1}}	\N
7822729	7815081	c.5890C>T/c.7304G>A	{"RYR1": {"c.5890C>T": 1, "c.7304G>A": 1}}	\N
7822730	7815081	c.6628G>T/c.13760C>T	{"RYR1": {"c.6628G>T": 1, "c.13760C>T": 1}}	\N
7822731	7815081	c.6302T>A/c.6502G>A	{"RYR1": {"c.6302T>A": 1, "c.6502G>A": 1}}	\N
7822732	7815081	c.12149C>A/c.14270G>A	{"RYR1": {"c.12149C>A": 1, "c.14270G>A": 1}}	\N
7822733	7815081	c.6488G>C/c.7292A>T	{"RYR1": {"c.6488G>C": 1, "c.7292A>T": 1}}	\N
7822734	7815081	c.488G>T/c.14813T>C	{"RYR1": {"c.488G>T": 1, "c.14813T>C": 1}}	\N
7822735	7815081	c.6478G>A/c.14803G>A	{"RYR1": {"c.6478G>A": 1, "c.14803G>A": 1}}	\N
7822736	7815081	c.1021G>A/c.7487C>T	{"RYR1": {"c.1021G>A": 1, "c.7487C>T": 1}}	\N
7822737	7815081	c.6617C>T/c.13702C>G	{"RYR1": {"c.6617C>T": 1, "c.13702C>G": 1}}	\N
7822738	7815081	c.7358T>C/c.9676G>C	{"RYR1": {"c.7358T>C": 1, "c.9676G>C": 1}}	\N
7822739	7815081	c.625G>A/c.1589G>A	{"RYR1": {"c.625G>A": 1, "c.1589G>A": 1}}	\N
7822740	7815081	c.1615T>C/c.9356G>A	{"RYR1": {"c.1615T>C": 1, "c.9356G>A": 1}}	\N
7822741	7815081	c.463C>A/c.12398A>G	{"RYR1": {"c.463C>A": 1, "c.12398A>G": 1}}	\N
7822742	7815081	c.1654C>T/c.12398A>G	{"RYR1": {"c.1654C>T": 1, "c.12398A>G": 1}}	\N
7822743	7815081	c.3166G>C/c.14558C>T	{"RYR1": {"c.3166G>C": 1, "c.14558C>T": 1}}	\N
7822744	7815081	c.463C>A/c.1201C>A	{"RYR1": {"c.463C>A": 1, "c.1201C>A": 1}}	\N
7822745	7815081	c.1630G>T/c.14270G>A	{"RYR1": {"c.1630G>T": 1, "c.14270G>A": 1}}	\N
7822746	7815081	c.7084G>A/c.7210G>A	{"RYR1": {"c.7084G>A": 1, "c.7210G>A": 1}}	\N
7822747	7815081	c.5341T>C/c.7291G>T	{"RYR1": {"c.5341T>C": 1, "c.7291G>T": 1}}	\N
7822748	7815081	c.1840C>T/c.2537C>T	{"RYR1": {"c.1840C>T": 1, "c.2537C>T": 1}}	\N
7822749	7815081	c.7879G>C/c.14449A>T	{"RYR1": {"c.7879G>C": 1, "c.14449A>T": 1}}	\N
7822750	7815081	c.12121C>T/c.14918C>T	{"RYR1": {"c.12121C>T": 1, "c.14918C>T": 1}}	\N
7822751	7815081	c.38T>G/c.7760A>G	{"RYR1": {"c.38T>G": 1, "c.7760A>G": 1}}	\N
7822752	7815081	c.12149C>A/c.13994_13995delTCinsCT	{"RYR1": {"c.12149C>A": 1, "c.13994_13995delTCinsCT": 1}}	\N
7822753	7815081	c.6488G>A/c.11126C>T	{"RYR1": {"c.6488G>A": 1, "c.11126C>T": 1}}	\N
7822754	7815081	c.1453A>G/c.1840C>T	{"RYR1": {"c.1453A>G": 1, "c.1840C>T": 1}}	\N
7822755	7815081	c.6349G>C/c.6640G>A	{"RYR1": {"c.6349G>C": 1, "c.6640G>A": 1}}	\N
7822756	7815081	c.3418C>T/c.7282G>A	{"RYR1": {"c.3418C>T": 1, "c.7282G>A": 1}}	\N
7822757	7815081	c.3127C>T/c.12149C>A	{"RYR1": {"c.3127C>T": 1, "c.12149C>A": 1}}	\N
7822758	7815081	c.7373G>T/c.14197T>G	{"RYR1": {"c.7373G>T": 1, "c.14197T>G": 1}}	\N
7822759	7815081	c.11120G>T/c.14512C>G	{"RYR1": {"c.11120G>T": 1, "c.14512C>G": 1}}	\N
7822760	7815081	c.7291G>T/c.13918A>G	{"RYR1": {"c.7291G>T": 1, "c.13918A>G": 1}}	\N
7822761	7815081	c.1021G>C/c.1411C>T	{"RYR1": {"c.1021G>C": 1, "c.1411C>T": 1}}	\N
7822762	7815081	c.7090T>G/c.8290G>A	{"RYR1": {"c.7090T>G": 1, "c.8290G>A": 1}}	\N
7822763	7815081	c.528G>T/c.14477C>T	{"RYR1": {"c.528G>T": 1, "c.14477C>T": 1}}	\N
7822764	7815081	c.1615T>G/c.14879T>A	{"RYR1": {"c.1615T>G": 1, "c.14879T>A": 1}}	\N
7822765	7815081	c.103T>C/c.14186A>C	{"RYR1": {"c.103T>C": 1, "c.14186A>C": 1}}	\N
7822766	7815081	c.7523G>A/c.9850T>A	{"RYR1": {"c.7523G>A": 1, "c.9850T>A": 1}}	\N
7822767	7815081	c.2996G>A/c.14210G>A	{"RYR1": {"c.2996G>A": 1, "c.14210G>A": 1}}	\N
7822768	7815081	c.3418C>T/c.7304G>A	{"RYR1": {"c.3418C>T": 1, "c.7304G>A": 1}}	\N
7822769	7815081	c.7210G>A/c.7522C>T	{"RYR1": {"c.7210G>A": 1, "c.7522C>T": 1}}	\N
7822770	7815081	c.119G>C/c.14477C>T	{"RYR1": {"c.119G>C": 1, "c.14477C>T": 1}}	\N
7822771	7815081	c.3418C>T/c.7304G>T	{"RYR1": {"c.3418C>T": 1, "c.7304G>T": 1}}	\N
7822772	7815081	c.5890C>T/c.14918C>T	{"RYR1": {"c.5890C>T": 1, "c.14918C>T": 1}}	\N
7822773	7815081	c.7355G>C/c.7372C>T	{"RYR1": {"c.7355G>C": 1, "c.7372C>T": 1}}	\N
7822774	7815081	c.1475G>A/c.14627A>G	{"RYR1": {"c.1475G>A": 1, "c.14627A>G": 1}}	\N
7822775	7815081	c.3166G>C/c.7528T>C	{"RYR1": {"c.3166G>C": 1, "c.7528T>C": 1}}	\N
7822776	7815081	c.9797T>C/c.12700G>C	{"RYR1": {"c.9797T>C": 1, "c.12700G>C": 1}}	\N
7822777	7815081	c.1411C>T/c.1597C>T	{"RYR1": {"c.1411C>T": 1, "c.1597C>T": 1}}	\N
7822778	7815081	c.7063C>T/c.8638G>A	{"RYR1": {"c.7063C>T": 1, "c.8638G>A": 1}}	\N
7822779	7815081	c.5890C>T/c.7282G>A	{"RYR1": {"c.5890C>T": 1, "c.7282G>A": 1}}	\N
7822780	7815081	c.2654G>A/c.14512C>G	{"RYR1": {"c.2654G>A": 1, "c.14512C>G": 1}}	\N
7822781	7815081	c.6478G>A/c.7007G>A	{"RYR1": {"c.6478G>A": 1, "c.7007G>A": 1}}	\N
7822782	7815081	c.8198G>A/c.14539G>C	{"RYR1": {"c.8198G>A": 1, "c.14539G>C": 1}}	\N
7822783	7815081	c.1202G>T/c.10043G>A	{"RYR1": {"c.1202G>T": 1, "c.10043G>A": 1}}	\N
7822784	7815081	c.11132C>T/c.14627A>G	{"RYR1": {"c.11132C>T": 1, "c.14627A>G": 1}}	\N
7822785	7815081	c.5441T>A/c.6349G>C	{"RYR1": {"c.5441T>A": 1, "c.6349G>C": 1}}	\N
7822786	7815081	c.5186T>G/c.7291G>A	{"RYR1": {"c.5186T>G": 1, "c.7291G>A": 1}}	\N
7822787	7815081	c.6387C>G/c.10229C>A	{"RYR1": {"c.6387C>G": 1, "c.10229C>A": 1}}	\N
7822788	7815081	c.488G>T/c.10043G>A	{"RYR1": {"c.488G>T": 1, "c.10043G>A": 1}}	\N
7822789	7815081	c.7018T>C/c.7360C>T	{"RYR1": {"c.7018T>C": 1, "c.7360C>T": 1}}	\N
7822790	7815081	c.7060G>A/c.12064A>G	{"RYR1": {"c.7060G>A": 1, "c.12064A>G": 1}}	\N
7822791	7815081	c.742G>C/c.7073T>A	{"RYR1": {"c.742G>C": 1, "c.7073T>A": 1}}	\N
7822792	7815081	c.6488G>C/c.11126C>T	{"RYR1": {"c.6488G>C": 1, "c.11126C>T": 1}}	\N
7822793	7815081	c.1615T>C/c.11132C>T	{"RYR1": {"c.1615T>C": 1, "c.11132C>T": 1}}	\N
7822794	7815081	c.487C>T/c.12028G>A	{"RYR1": {"c.487C>T": 1, "c.12028G>A": 1}}	\N
7822795	7815081	c.7879G>C/c.8198G>A	{"RYR1": {"c.7879G>C": 1, "c.8198G>A": 1}}	\N
7822796	7815081	c.1565A>G/c.10042C>T	{"RYR1": {"c.1565A>G": 1, "c.10042C>T": 1}}	\N
7822797	7815081	c.487C>T/c.3095G>A	{"RYR1": {"c.487C>T": 1, "c.3095G>A": 1}}	\N
7822798	7815081	c.1589G>A/c.7073T>A	{"RYR1": {"c.1589G>A": 1, "c.7073T>A": 1}}	\N
7822799	7815081	c.7073T>A/c.14545G>A	{"RYR1": {"c.7073T>A": 1, "c.14545G>A": 1}}	\N
7822800	7815081	c.1834G>C/c.7360C>T	{"RYR1": {"c.1834G>C": 1, "c.7360C>T": 1}}	\N
7822801	7815081	c.5186T>G/c.7291G>T	{"RYR1": {"c.5186T>G": 1, "c.7291G>T": 1}}	\N
7822802	7815081	c.7018T>C/c.7372C>T	{"RYR1": {"c.7018T>C": 1, "c.7372C>T": 1}}	\N
7822803	7815081	c.1597C>T/c.7528T>C	{"RYR1": {"c.1597C>T": 1, "c.7528T>C": 1}}	\N
7822804	7815081	c.7358T>C/c.14509C>G	{"RYR1": {"c.7358T>C": 1, "c.14509C>G": 1}}	\N
7822805	7815081	c.5441T>A/c.7879G>C	{"RYR1": {"c.5441T>A": 1, "c.7879G>C": 1}}	\N
7822806	7815081	c.1597C>T/c.5440A>G	{"RYR1": {"c.1597C>T": 1, "c.5440A>G": 1}}	\N
7822807	7815081	c.6488G>C/c.11947C>T	{"RYR1": {"c.6488G>C": 1, "c.11947C>T": 1}}	\N
7822808	7815081	c.1615T>G/c.9356G>A	{"RYR1": {"c.1615T>G": 1, "c.9356G>A": 1}}	\N
7822809	7815081	c.6488G>T/c.6742C>T	{"RYR1": {"c.6488G>T": 1, "c.6742C>T": 1}}	\N
7822810	7815081	c.9797T>C/c.12700G>T	{"RYR1": {"c.9797T>C": 1, "c.12700G>T": 1}}	\N
7822811	7815081	c.1565A>G/c.7760A>G	{"RYR1": {"c.1565A>G": 1, "c.7760A>G": 1}}	\N
7822812	7815081	c.11947C>T/c.14539G>C	{"RYR1": {"c.11947C>T": 1, "c.14539G>C": 1}}	\N
7822813	7815081	c.6487C>T/c.14471T>C	{"RYR1": {"c.6487C>T": 1, "c.14471T>C": 1}}	\N
7822814	7815081	c.7035C>A/c.11947C>T	{"RYR1": {"c.7035C>A": 1, "c.11947C>T": 1}}	\N
7822815	7815081	c.7355G>A/c.7372C>T	{"RYR1": {"c.7355G>A": 1, "c.7372C>T": 1}}	\N
7822816	7815081	c.7007G>A/c.10043G>A	{"RYR1": {"c.7007G>A": 1, "c.10043G>A": 1}}	\N
7822817	7815081	c.2537C>T/c.7523G>A	{"RYR1": {"c.2537C>T": 1, "c.7523G>A": 1}}	\N
7822818	7815081	c.11315G>A/c.13913G>A	{"RYR1": {"c.11315G>A": 1, "c.13913G>A": 1}}	\N
7822819	7815081	c.9652G>A/c.12149C>A	{"RYR1": {"c.9652G>A": 1, "c.12149C>A": 1}}	\N
7822820	7815081	c.6617C>G/c.7292A>T	{"RYR1": {"c.6617C>G": 1, "c.7292A>T": 1}}	\N
7822821	7815081	c.625G>A/c.1840C>T	{"RYR1": {"c.625G>A": 1, "c.1840C>T": 1}}	\N
7822822	7815081	c.7523G>A/c.14270G>A	{"RYR1": {"c.7523G>A": 1, "c.14270G>A": 1}}	\N
7822823	7815081	c.1201C>G/c.14627A>G	{"RYR1": {"c.1201C>G": 1, "c.14627A>G": 1}}	\N
7822824	7815081	c.7522C>T/c.11947C>T	{"RYR1": {"c.7522C>T": 1, "c.11947C>T": 1}}	\N
7822825	7815081	c.6617C>T/c.14387A>G	{"RYR1": {"c.6617C>T": 1, "c.14387A>G": 1}}	\N
7822826	7815081	c.488G>A/c.1021G>A	{"RYR1": {"c.488G>A": 1, "c.1021G>A": 1}}	\N
7822827	7815081	c.742G>A/c.7073T>A	{"RYR1": {"c.742G>A": 1, "c.7073T>A": 1}}	\N
7822828	7815081	c.488G>A/c.1021G>C	{"RYR1": {"c.488G>A": 1, "c.1021G>C": 1}}	\N
7822829	7815081	c.1597C>A/c.7124G>C	{"RYR1": {"c.1597C>A": 1, "c.7124G>C": 1}}	\N
7822830	7815081	c.529C>T/c.11953T>C	{"RYR1": {"c.529C>T": 1, "c.11953T>C": 1}}	\N
7822831	7815081	c.1589G>A/c.14639T>C	{"RYR1": {"c.1589G>A": 1, "c.14639T>C": 1}}	\N
7822832	7815081	c.625G>A/c.7036G>A	{"RYR1": {"c.625G>A": 1, "c.7036G>A": 1}}	\N
7822833	7815081	c.7090T>G/c.12533G>T	{"RYR1": {"c.7090T>G": 1, "c.12533G>T": 1}}	\N
7822834	7815081	c.1024G>A/c.1201C>T	{"RYR1": {"c.1024G>A": 1, "c.1201C>T": 1}}	\N
7822835	7815081	c.1021G>C/c.7307G>A	{"RYR1": {"c.1021G>C": 1, "c.7307G>A": 1}}	\N
7822836	7815081	c.947G>T/c.12149C>A	{"RYR1": {"c.947G>T": 1, "c.12149C>A": 1}}	\N
7822837	7815081	c.6617C>G/c.12848A>T	{"RYR1": {"c.6617C>G": 1, "c.12848A>T": 1}}	\N
7822838	7815081	c.7355G>C/c.7360C>T	{"RYR1": {"c.7355G>C": 1, "c.7360C>T": 1}}	\N
7822839	7815081	c.982C>T/c.6302T>A	{"RYR1": {"c.982C>T": 1, "c.6302T>A": 1}}	\N
7822840	7815081	c.7076G>A/c.14458G>A	{"RYR1": {"c.7076G>A": 1, "c.14458G>A": 1}}	\N
7822841	7815081	c.1597C>T/c.12064A>G	{"RYR1": {"c.1597C>T": 1, "c.12064A>G": 1}}	\N
7822842	7815081	c.7373G>T/c.14364+1G>T	{"RYR1": {"c.7373G>T": 1, "c.14364+1G>T": 1}}	\N
7822843	7815081	c.1453A>G/c.7036G>A	{"RYR1": {"c.1453A>G": 1, "c.7036G>A": 1}}	\N
7822844	7815081	c.13505A>G/c.14209C>T	{"RYR1": {"c.13505A>G": 1, "c.14209C>T": 1}}	\N
7822845	7815081	c.6488G>C/c.14387A>G	{"RYR1": {"c.6488G>C": 1, "c.14387A>G": 1}}	\N
7822846	7815081	c.251C>T/c.7076G>A	{"RYR1": {"c.251C>T": 1, "c.7076G>A": 1}}	\N
7822847	7815081	c.1615T>C/c.8729C>T	{"RYR1": {"c.1615T>C": 1, "c.8729C>T": 1}}	\N
7822848	7815081	c.7282G>A/c.14126C>T	{"RYR1": {"c.7282G>A": 1, "c.14126C>T": 1}}	\N
7822849	7815081	c.488G>A/c.6387C>G	{"RYR1": {"c.488G>A": 1, "c.6387C>G": 1}}	\N
7822850	7815081	c.1201C>T/c.14424C>A	{"RYR1": {"c.1201C>T": 1, "c.14424C>A": 1}}	\N
7822851	7815081	c.1615T>C/c.8054C>T	{"RYR1": {"c.1615T>C": 1, "c.8054C>T": 1}}	\N
7822852	7815081	c.1615T>G/c.14201G>A	{"RYR1": {"c.1615T>G": 1, "c.14201G>A": 1}}	\N
7822853	7815081	c.6612C>G/c.8527T>C	{"RYR1": {"c.6612C>G": 1, "c.8527T>C": 1}}	\N
7822854	7815081	c.496G>A/c.14545G>A	{"RYR1": {"c.496G>A": 1, "c.14545G>A": 1}}	\N
7822855	7815081	c.6488G>A/c.12355A>T	{"RYR1": {"c.6488G>A": 1, "c.12355A>T": 1}}	\N
7822856	7815081	c.6617C>T/c.10237A>T	{"RYR1": {"c.6617C>T": 1, "c.10237A>T": 1}}	\N
7822857	7815081	c.14051T>C/c.14918C>T	{"RYR1": {"c.14051T>C": 1, "c.14918C>T": 1}}	\N
7822858	7815081	c.14210G>A/c.14424C>A	{"RYR1": {"c.14210G>A": 1, "c.14424C>A": 1}}	\N
7822859	7815081	c.14270G>A/c.14512C>G	{"RYR1": {"c.14270G>A": 1, "c.14512C>G": 1}}	\N
7822860	7815081	c.1841G>T/c.13760C>T	{"RYR1": {"c.1841G>T": 1, "c.13760C>T": 1}}	\N
7822861	7815081	c.1630G>T/c.9850T>A	{"RYR1": {"c.1630G>T": 1, "c.9850T>A": 1}}	\N
7822862	7815081	c.487C>T/c.6635T>A	{"RYR1": {"c.487C>T": 1, "c.6635T>A": 1}}	\N
7822863	7815081	c.7042_7044delGAG/c.13702C>G	{"RYR1": {"c.13702C>G": 1, "c.7042_7044delGAG": 1}}	\N
7822864	7815081	c.1630G>T/c.14582G>A	{"RYR1": {"c.1630G>T": 1, "c.14582G>A": 1}}	\N
7822865	7815081	c.6349G>C/c.11723A>T	{"RYR1": {"c.6349G>C": 1, "c.11723A>T": 1}}	\N
7822866	7815081	c.7042_7044delGAG/c.8527T>C	{"RYR1": {"c.8527T>C": 1, "c.7042_7044delGAG": 1}}	\N
7822867	7815081	c.97A>G/c.7771C>T	{"RYR1": {"c.97A>G": 1, "c.7771C>T": 1}}	\N
7822868	7815081	c.1565A>C/c.2537C>T	{"RYR1": {"c.1565A>C": 1, "c.2537C>T": 1}}	\N
7822869	7815081	c.7032G>C/c.12149C>A	{"RYR1": {"c.7032G>C": 1, "c.12149C>A": 1}}	\N
7822870	7815081	c.641C>T/c.1840C>T	{"RYR1": {"c.641C>T": 1, "c.1840C>T": 1}}	\N
7822871	7815081	c.7300G>A/c.9268G>A	{"RYR1": {"c.7300G>A": 1, "c.9268G>A": 1}}	\N
7822872	7815081	c.7123G>A/c.10229C>A	{"RYR1": {"c.7123G>A": 1, "c.10229C>A": 1}}	\N
7822873	7815081	c.7035C>A/c.7292A>T	{"RYR1": {"c.7035C>A": 1, "c.7292A>T": 1}}	\N
7822874	7815081	c.7310C>T/c.14471T>C	{"RYR1": {"c.7310C>T": 1, "c.14471T>C": 1}}	\N
7822875	7815081	c.11708G>A/c.14818G>A	{"RYR1": {"c.11708G>A": 1, "c.14818G>A": 1}}	\N
7822876	7815081	c.742G>A/c.5186T>G	{"RYR1": {"c.742G>A": 1, "c.5186T>G": 1}}	\N
7822877	7815081	c.7355G>A/c.7360C>T	{"RYR1": {"c.7355G>A": 1, "c.7360C>T": 1}}	\N
7822878	7815081	c.97A>G/c.7771C>G	{"RYR1": {"c.97A>G": 1, "c.7771C>G": 1}}	\N
7822879	7815081	c.6612C>G/c.13990T>C	{"RYR1": {"c.6612C>G": 1, "c.13990T>C": 1}}	\N
7822880	7815081	c.6488G>C/c.12355A>T	{"RYR1": {"c.6488G>C": 1, "c.12355A>T": 1}}	\N
7822881	7815081	c.97A>G/c.4775C>T	{"RYR1": {"c.97A>G": 1, "c.4775C>T": 1}}	\N
7822882	7815081	c.6388G>A/c.14210G>A	{"RYR1": {"c.6388G>A": 1, "c.14210G>A": 1}}	\N
7822883	7815081	c.1840C>T/c.14567C>G	{"RYR1": {"c.1840C>T": 1, "c.14567C>G": 1}}	\N
7822884	7815081	c.7361G>A/c.8290G>A	{"RYR1": {"c.7361G>A": 1, "c.8290G>A": 1}}	\N
7822885	7815081	c.6502G>A/c.7073T>A	{"RYR1": {"c.6502G>A": 1, "c.7073T>A": 1}}	\N
7822886	7815081	c.7090T>G/c.14693T>C	{"RYR1": {"c.7090T>G": 1, "c.14693T>C": 1}}	\N
7822887	7815081	c.652G>A/c.7354C>T	{"RYR1": {"c.652G>A": 1, "c.7354C>T": 1}}	\N
7822888	7815081	c.1453A>G/c.7048G>A	{"RYR1": {"c.1453A>G": 1, "c.7048G>A": 1}}	\N
7822889	7815081	c.7778G>A/c.14918C>T	{"RYR1": {"c.7778G>A": 1, "c.14918C>T": 1}}	\N
7822890	7815081	c.1841G>T/c.12398A>G	{"RYR1": {"c.1841G>T": 1, "c.12398A>G": 1}}	\N
7822891	7815081	c.7060G>A/c.14813T>C	{"RYR1": {"c.7060G>A": 1, "c.14813T>C": 1}}	\N
7822892	7815081	c.7360C>T/c.11813G>A	{"RYR1": {"c.7360C>T": 1, "c.11813G>A": 1}}	\N
7822893	7815081	c.6743G>A/c.7282G>A	{"RYR1": {"c.6743G>A": 1, "c.7282G>A": 1}}	\N
7822894	7815081	c.6388G>A/c.6838G>A	{"RYR1": {"c.6388G>A": 1, "c.6838G>A": 1}}	\N
7822895	7815081	c.7373G>A/c.14693T>C	{"RYR1": {"c.7373G>A": 1, "c.14693T>C": 1}}	\N
7822896	7815081	c.529C>T/c.14567C>G	{"RYR1": {"c.529C>T": 1, "c.14567C>G": 1}}	\N
7822897	7815081	c.3166G>C/c.7487C>T	{"RYR1": {"c.3166G>C": 1, "c.7487C>T": 1}}	\N
7822898	7815081	c.7199A>G/c.14545G>A	{"RYR1": {"c.7199A>G": 1, "c.14545G>A": 1}}	\N
7822899	7815081	c.103T>C/c.7073T>A	{"RYR1": {"c.103T>C": 1, "c.7073T>A": 1}}	\N
7822900	7815081	c.6617C>G/c.14387A>G	{"RYR1": {"c.6617C>G": 1, "c.14387A>G": 1}}	\N
7822901	7815081	c.7358T>C/c.14558C>T	{"RYR1": {"c.7358T>C": 1, "c.14558C>T": 1}}	\N
7822902	7815081	c.9797T>C/c.14539G>C	{"RYR1": {"c.9797T>C": 1, "c.14539G>C": 1}}	\N
7822903	7815081	c.8026C>T/c.8926C>T	{"RYR1": {"c.8026C>T": 1, "c.8926C>T": 1}}	\N
7822904	7815081	c.130C>T/c.131G>A	{"RYR1": {"c.130C>T": 1, "c.131G>A": 1}}	\N
7822905	7815081	c.9356G>A/c.14210G>A	{"RYR1": {"c.9356G>A": 1, "c.14210G>A": 1}}	\N
7822906	7815081	c.5890C>T/c.6488G>C	{"RYR1": {"c.5890C>T": 1, "c.6488G>C": 1}}	\N
7822907	7815081	c.5033A>G/c.6349G>C	{"RYR1": {"c.5033A>G": 1, "c.6349G>C": 1}}	\N
7822908	7815081	c.7063C>T/c.12028G>A	{"RYR1": {"c.7063C>T": 1, "c.12028G>A": 1}}	\N
7822909	7815081	c.7307G>A/c.7361G>A	{"RYR1": {"c.7307G>A": 1, "c.7361G>A": 1}}	\N
7822910	7815081	c.5890C>T/c.6488G>A	{"RYR1": {"c.5890C>T": 1, "c.6488G>A": 1}}	\N
7822911	7815081	c.1021G>C/c.12553G>A	{"RYR1": {"c.1021G>C": 1, "c.12553G>A": 1}}	\N
7822912	7815081	c.7084G>A/c.7317G>C	{"RYR1": {"c.7084G>A": 1, "c.7317G>C": 1}}	\N
7822913	7815081	c.1202G>A/c.6635T>A	{"RYR1": {"c.1202G>A": 1, "c.6635T>A": 1}}	\N
7822914	7815081	c.1840C>T/c.10042C>T	{"RYR1": {"c.1840C>T": 1, "c.10042C>T": 1}}	\N
7822915	7815081	c.467G>A/c.7354C>T	{"RYR1": {"c.467G>A": 1, "c.7354C>T": 1}}	\N
7822916	7815081	c.6502G>A/c.10252A>G	{"RYR1": {"c.6502G>A": 1, "c.10252A>G": 1}}	\N
7822917	7815081	c.533A>G/c.7879G>A	{"RYR1": {"c.533A>G": 1, "c.7879G>A": 1}}	\N
7822918	7815081	c.488G>T/c.2537C>T	{"RYR1": {"c.488G>T": 1, "c.2537C>T": 1}}	\N
7822919	7815081	c.7304G>T/c.7317G>C	{"RYR1": {"c.7304G>T": 1, "c.7317G>C": 1}}	\N
7822920	7815081	c.479A>G/c.6628G>T	{"RYR1": {"c.479A>G": 1, "c.6628G>T": 1}}	\N
7822921	7815081	c.6488G>C/c.14509C>G	{"RYR1": {"c.6488G>C": 1, "c.14509C>G": 1}}	\N
7822922	7815081	c.533A>G/c.1460T>C	{"RYR1": {"c.533A>G": 1, "c.1460T>C": 1}}	\N
7822923	7815081	c.3667G>A/c.7035C>A	{"RYR1": {"c.3667G>A": 1, "c.7035C>A": 1}}	\N
7822924	7815081	c.7123G>A/c.14471T>C	{"RYR1": {"c.7123G>A": 1, "c.14471T>C": 1}}	\N
7822925	7815081	c.1209C>G/c.14803G>A	{"RYR1": {"c.1209C>G": 1, "c.14803G>A": 1}}	\N
7822926	7815081	c.1615T>G/c.8729C>T	{"RYR1": {"c.1615T>G": 1, "c.8729C>T": 1}}	\N
7822927	7815081	c.190T>C/c.14497C>T	{"RYR1": {"c.190T>C": 1, "c.14497C>T": 1}}	\N
7822928	7815081	c.1615T>G/c.8054C>T	{"RYR1": {"c.1615T>G": 1, "c.8054C>T": 1}}	\N
7822929	7815081	c.251C>T/c.7123G>A	{"RYR1": {"c.251C>T": 1, "c.7123G>A": 1}}	\N
7822930	7815081	c.1100G>A/c.1615T>G	{"RYR1": {"c.1100G>A": 1, "c.1615T>G": 1}}	\N
7822931	7815081	c.6838G>A/c.14422_14423delinsAA	{"RYR1": {"c.6838G>A": 1, "c.14422_14423delinsAA": 1}}	\N
7822932	7815081	c.7310C>T/c.10229C>A	{"RYR1": {"c.7310C>T": 1, "c.10229C>A": 1}}	\N
7822933	7815081	c.6488G>T/c.14002C>T	{"RYR1": {"c.6488G>T": 1, "c.14002C>T": 1}}	\N
7822934	7815081	c.1202G>A/c.14364+1G>T	{"RYR1": {"c.1202G>A": 1, "c.14364+1G>T": 1}}	\N
7822935	7815081	c.6502G>A/c.14509C>G	{"RYR1": {"c.6502G>A": 1, "c.14509C>G": 1}}	\N
7822936	7815081	c.1460T>C/c.7042_7044delGAG	{"RYR1": {"c.1460T>C": 1, "c.7042_7044delGAG": 1}}	\N
7822937	7815081	c.1100G>A/c.1615T>C	{"RYR1": {"c.1100G>A": 1, "c.1615T>C": 1}}	\N
7822938	7815081	c.5890C>T/c.6488G>T	{"RYR1": {"c.5890C>T": 1, "c.6488G>T": 1}}	\N
7822939	7815081	c.1841G>T/c.7879G>A	{"RYR1": {"c.1841G>T": 1, "c.7879G>A": 1}}	\N
7822940	7815081	c.7036G>A/c.14458G>T	{"RYR1": {"c.7036G>A": 1, "c.14458G>T": 1}}	\N
7822941	7815081	c.6349G>C/c.14197T>G	{"RYR1": {"c.6349G>C": 1, "c.14197T>G": 1}}	\N
7822942	7815081	c.6502G>A/c.12355A>T	{"RYR1": {"c.6502G>A": 1, "c.12355A>T": 1}}	\N
7822943	7815081	c.496G>A/c.6488G>T	{"RYR1": {"c.496G>A": 1, "c.6488G>T": 1}}	\N
7822944	7815081	c.119G>C/c.6502G>A	{"RYR1": {"c.119G>C": 1, "c.6502G>A": 1}}	\N
7822945	7815081	c.12149C>A/c.13702C>G	{"RYR1": {"c.12149C>A": 1, "c.13702C>G": 1}}	\N
7822946	7815081	c.3095G>A/c.7007G>A	{"RYR1": {"c.3095G>A": 1, "c.7007G>A": 1}}	\N
7822947	7815081	c.7360C>T/c.8926C>T	{"RYR1": {"c.7360C>T": 1, "c.8926C>T": 1}}	\N
7822948	7815081	c.3166G>C/c.7307G>A	{"RYR1": {"c.3166G>C": 1, "c.7307G>A": 1}}	\N
7822949	7815081	c.641C>T/c.7036G>A	{"RYR1": {"c.641C>T": 1, "c.7036G>A": 1}}	\N
7822950	7815081	c.6488G>T/c.8198G>A	{"RYR1": {"c.6488G>T": 1, "c.8198G>A": 1}}	\N
7822951	7815081	c.496G>A/c.6488G>C	{"RYR1": {"c.496G>A": 1, "c.6488G>C": 1}}	\N
7822952	7815081	c.1654C>T/c.6710G>A	{"RYR1": {"c.1654C>T": 1, "c.6710G>A": 1}}	\N
7822953	7815081	c.6488G>A/c.14509C>G	{"RYR1": {"c.6488G>A": 1, "c.14509C>G": 1}}	\N
7822954	7815081	c.7307G>A/c.7373G>A	{"RYR1": {"c.7307G>A": 1, "c.7373G>A": 1}}	\N
7822955	7815081	c.1565A>G/c.14813T>C	{"RYR1": {"c.1565A>G": 1, "c.14813T>C": 1}}	\N
7822956	7815081	c.11708G>A/c.15059G>C	{"RYR1": {"c.11708G>A": 1, "c.15059G>C": 1}}	\N
7822957	7815081	c.533A>C/c.7879G>C	{"RYR1": {"c.533A>C": 1, "c.7879G>C": 1}}	\N
7822958	7815081	c.2996G>A/c.8026C>T	{"RYR1": {"c.2996G>A": 1, "c.8026C>T": 1}}	\N
7822959	7815081	c.6488G>A/c.14387A>G	{"RYR1": {"c.6488G>A": 1, "c.14387A>G": 1}}	\N
7822960	7815081	c.1021G>C/c.1459C>G	{"RYR1": {"c.1021G>C": 1, "c.1459C>G": 1}}	\N
7822961	7815081	c.3527C>T/c.7007G>A	{"RYR1": {"c.3527C>T": 1, "c.7007G>A": 1}}	\N
7822962	7815081	c.496G>A/c.6488G>A	{"RYR1": {"c.496G>A": 1, "c.6488G>A": 1}}	\N
7822963	7815081	c.6487C>T/c.12689T>G	{"RYR1": {"c.6487C>T": 1, "c.12689T>G": 1}}	\N
7822964	7815081	c.7372C>T/c.14678G>A	{"RYR1": {"c.7372C>T": 1, "c.14678G>A": 1}}	\N
7822965	7815081	c.7304G>T/c.14581C>T	{"RYR1": {"c.7304G>T": 1, "c.14581C>T": 1}}	\N
7822966	7815081	c.467G>A/c.7523G>A	{"RYR1": {"c.467G>A": 1, "c.7523G>A": 1}}	\N
7822967	7815081	c.7522C>T/c.14270G>A	{"RYR1": {"c.7522C>T": 1, "c.14270G>A": 1}}	\N
7822968	7815081	c.6502G>A/c.6743G>A	{"RYR1": {"c.6502G>A": 1, "c.6743G>A": 1}}	\N
7822969	7815081	c.5024T>C/c.6502G>A	{"RYR1": {"c.5024T>C": 1, "c.6502G>A": 1}}	\N
7822970	7815081	c.7307G>A/c.7373G>T	{"RYR1": {"c.7307G>A": 1, "c.7373G>T": 1}}	\N
7822971	7815081	c.1202G>T/c.2537C>T	{"RYR1": {"c.1202G>T": 1, "c.2537C>T": 1}}	\N
7822972	7815081	c.6488G>A/c.6743G>A	{"RYR1": {"c.6488G>A": 1, "c.6743G>A": 1}}	\N
7822973	7815081	c.7487C>T/c.14477C>T	{"RYR1": {"c.7487C>T": 1, "c.14477C>T": 1}}	\N
7822974	7815081	c.496G>A/c.7304G>T	{"RYR1": {"c.496G>A": 1, "c.7304G>T": 1}}	\N
7822975	7815081	c.7373G>A/c.12533G>T	{"RYR1": {"c.7373G>A": 1, "c.12533G>T": 1}}	\N
7822976	7815081	c.526G>A/c.12149C>A	{"RYR1": {"c.526G>A": 1, "c.12149C>A": 1}}	\N
7822977	7815081	c.7361G>A/c.11314C>T	{"RYR1": {"c.7361G>A": 1, "c.11314C>T": 1}}	\N
7822978	7815081	c.6617C>T/c.11947C>T	{"RYR1": {"c.6617C>T": 1, "c.11947C>T": 1}}	\N
7822979	7815081	c.1209C>G/c.7310C>T	{"RYR1": {"c.1209C>G": 1, "c.7310C>T": 1}}	\N
7822980	7815081	c.7304G>T/c.14678G>A	{"RYR1": {"c.7304G>T": 1, "c.14678G>A": 1}}	\N
7822981	7815081	c.526G>A/c.7358T>C	{"RYR1": {"c.526G>A": 1, "c.7358T>C": 1}}	\N
7822982	7815081	c.6548G>A/c.14497C>T	{"RYR1": {"c.6548G>A": 1, "c.14497C>T": 1}}	\N
7822983	7815081	c.6387C>G/c.9848G>A	{"RYR1": {"c.6387C>G": 1, "c.9848G>A": 1}}	\N
7822984	7815081	c.1021G>C/c.7528T>C	{"RYR1": {"c.1021G>C": 1, "c.7528T>C": 1}}	\N
7822985	7815081	c.6617C>G/c.14509C>G	{"RYR1": {"c.6617C>G": 1, "c.14509C>G": 1}}	\N
7822986	7815081	c.7291G>T/c.8518C>T	{"RYR1": {"c.7291G>T": 1, "c.8518C>T": 1}}	\N
7822987	7815081	c.11708G>A/c.15060G>C	{"RYR1": {"c.11708G>A": 1, "c.15060G>C": 1}}	\N
7822988	7815081	c.463C>A/c.8926C>T	{"RYR1": {"c.463C>A": 1, "c.8926C>T": 1}}	\N
7822989	7815081	c.7060G>A/c.14582G>A	{"RYR1": {"c.7060G>A": 1, "c.14582G>A": 1}}	\N
7822990	7815081	c.1615T>C/c.14201G>A	{"RYR1": {"c.1615T>C": 1, "c.14201G>A": 1}}	\N
7822991	7815081	c.496G>A/c.7304G>A	{"RYR1": {"c.496G>A": 1, "c.7304G>A": 1}}	\N
7822992	7815081	c.6628G>T/c.12398A>G	{"RYR1": {"c.6628G>T": 1, "c.12398A>G": 1}}	\N
7822993	7815081	c.7300G>A/c.8005G>A	{"RYR1": {"c.7300G>A": 1, "c.8005G>A": 1}}	\N
7822994	7815081	c.7282G>A/c.14814C>G	{"RYR1": {"c.7282G>A": 1, "c.14814C>G": 1}}	\N
7822995	7815081	c.6628G>T/c.7879G>A	{"RYR1": {"c.6628G>T": 1, "c.7879G>A": 1}}	\N
7822996	7815081	c.7358T>C/c.12848A>T	{"RYR1": {"c.7358T>C": 1, "c.12848A>T": 1}}	\N
7822997	7815081	c.533A>G/c.12121C>T	{"RYR1": {"c.533A>G": 1, "c.12121C>T": 1}}	\N
7822998	7815081	c.742G>C/c.5186T>G	{"RYR1": {"c.742G>C": 1, "c.5186T>G": 1}}	\N
7822999	7815081	c.7385C>T/c.14209C>T	{"RYR1": {"c.7385C>T": 1, "c.14209C>T": 1}}	\N
7823000	7815081	c.496G>A/c.14918C>T	{"RYR1": {"c.496G>A": 1, "c.14918C>T": 1}}	\N
7823001	7815081	c.38T>G/c.6037A>C	{"RYR1": {"c.38T>G": 1, "c.6037A>C": 1}}	\N
7823002	7815081	c.7291G>A/c.13702C>G	{"RYR1": {"c.7291G>A": 1, "c.13702C>G": 1}}	\N
7823003	7815081	c.97A>G/c.4763C>T	{"RYR1": {"c.97A>G": 1, "c.4763C>T": 1}}	\N
7823004	7815081	c.12115A>T/c.14477C>T	{"RYR1": {"c.12115A>T": 1, "c.14477C>T": 1}}	\N
7823005	7815081	c.7084G>A/c.14678G>A	{"RYR1": {"c.7084G>A": 1, "c.14678G>A": 1}}	\N
7823006	7815081	c.7035C>A/c.9868G>A	{"RYR1": {"c.7035C>A": 1, "c.9868G>A": 1}}	\N
7823007	7815081	c.3418C>T/c.14545G>A	{"RYR1": {"c.3418C>T": 1, "c.14545G>A": 1}}	\N
7823008	7815081	c.7372C>T/c.13702C>G	{"RYR1": {"c.7372C>T": 1, "c.13702C>G": 1}}	\N
7823009	7815081	c.7372C>T/c.13918A>G	{"RYR1": {"c.7372C>T": 1, "c.13918A>G": 1}}	\N
7823010	7815081	c.12242C>T/c.12700G>C	{"RYR1": {"c.12242C>T": 1, "c.12700G>C": 1}}	\N
7823011	7815081	c.463C>A/c.14818G>A	{"RYR1": {"c.463C>A": 1, "c.14818G>A": 1}}	\N
7823012	7815081	c.7358T>C/c.12355A>T	{"RYR1": {"c.7358T>C": 1, "c.12355A>T": 1}}	\N
7823013	7815081	c.1202G>A/c.12533G>T	{"RYR1": {"c.1202G>A": 1, "c.12533G>T": 1}}	\N
7823014	7815081	c.1615T>C/c.5341T>C	{"RYR1": {"c.1615T>C": 1, "c.5341T>C": 1}}	\N
7823015	7815081	c.6377G>A/c.14803G>A	{"RYR1": {"c.6377G>A": 1, "c.14803G>A": 1}}	\N
7823016	7815081	c.1589G>A/c.8005G>A	{"RYR1": {"c.1589G>A": 1, "c.8005G>A": 1}}	\N
7823017	7815081	c.6488G>T/c.7487C>T	{"RYR1": {"c.6488G>T": 1, "c.7487C>T": 1}}	\N
7823018	7815081	c.5441T>A/c.12700G>C	{"RYR1": {"c.5441T>A": 1, "c.12700G>C": 1}}	\N
7823019	7815081	c.1615T>G/c.13672C>T	{"RYR1": {"c.1615T>G": 1, "c.13672C>T": 1}}	\N
7823020	7815081	c.7123G>A/c.13673G>A	{"RYR1": {"c.7123G>A": 1, "c.13673G>A": 1}}	\N
7823021	7815081	c.6387C>G/c.6599C>T	{"RYR1": {"c.6387C>G": 1, "c.6599C>T": 1}}	\N
7823022	7815081	c.12242C>T/c.12700G>T	{"RYR1": {"c.12242C>T": 1, "c.12700G>T": 1}}	\N
7823023	7815081	c.7042_7044delGAG/c.12848A>T	{"RYR1": {"c.12848A>T": 1, "c.7042_7044delGAG": 1}}	\N
7823024	7815081	c.1201C>G/c.7123G>A	{"RYR1": {"c.1201C>G": 1, "c.7123G>A": 1}}	\N
7823025	7815081	c.7007G>A/c.9652G>A	{"RYR1": {"c.7007G>A": 1, "c.9652G>A": 1}}	\N
7823026	7815081	c.1654C>T/c.6757C>T	{"RYR1": {"c.1654C>T": 1, "c.6757C>T": 1}}	\N
7823027	7815081	c.5441T>A/c.12700G>T	{"RYR1": {"c.5441T>A": 1, "c.12700G>T": 1}}	\N
7823028	7815081	c.7007G>A/c.12064A>G	{"RYR1": {"c.7007G>A": 1, "c.12064A>G": 1}}	\N
7823029	7815081	c.3667G>A/c.7036G>A	{"RYR1": {"c.3667G>A": 1, "c.7036G>A": 1}}	\N
7823030	7815081	c.7084G>A/c.14270G>A	{"RYR1": {"c.7084G>A": 1, "c.14270G>A": 1}}	\N
7823031	7815081	c.7018T>C/c.7300G>A	{"RYR1": {"c.7018T>C": 1, "c.7300G>A": 1}}	\N
7823032	7815081	c.7304G>A/c.13994_13995delTCinsCT	{"RYR1": {"c.7304G>A": 1, "c.13994_13995delTCinsCT": 1}}	\N
7823033	7815081	c.497A>G/c.1202G>T	{"RYR1": {"c.497A>G": 1, "c.1202G>T": 1}}	\N
7823034	7815081	c.4775C>T/c.6612C>G	{"RYR1": {"c.4775C>T": 1, "c.6612C>G": 1}}	\N
7823035	7815081	c.9310G>A/c.14524G>A	{"RYR1": {"c.9310G>A": 1, "c.14524G>A": 1}}	\N
7823036	7815081	c.14825G>T/c.14918C>T	{"RYR1": {"c.14825G>T": 1, "c.14918C>T": 1}}	\N
7823037	7815081	c.7042_7044delGAG/c.14424C>A	{"RYR1": {"c.14424C>A": 1, "c.7042_7044delGAG": 1}}	\N
7823038	7815081	c.7310C>T/c.13673G>A	{"RYR1": {"c.7310C>T": 1, "c.13673G>A": 1}}	\N
7823039	7815081	c.1565A>C/c.8189A>G	{"RYR1": {"c.1565A>C": 1, "c.8189A>G": 1}}	\N
7823040	7815081	c.8527T>C/c.11969G>T	{"RYR1": {"c.8527T>C": 1, "c.11969G>T": 1}}	\N
7823041	7815081	c.5441T>A/c.6628G>T	{"RYR1": {"c.5441T>A": 1, "c.6628G>T": 1}}	\N
7823042	7815081	c.1615T>C/c.12383C>T	{"RYR1": {"c.1615T>C": 1, "c.12383C>T": 1}}	\N
7823043	7815081	c.6037A>C/c.7007G>A	{"RYR1": {"c.6037A>C": 1, "c.7007G>A": 1}}	\N
7823044	7815081	c.526G>A/c.6487C>T	{"RYR1": {"c.526G>A": 1, "c.6487C>T": 1}}	\N
7823045	7815081	c.652G>A/c.1654C>T	{"RYR1": {"c.652G>A": 1, "c.1654C>T": 1}}	\N
7823046	7815081	c.1565A>G/c.8638G>A	{"RYR1": {"c.1565A>G": 1, "c.8638G>A": 1}}	\N
7823047	7815081	c.5441T>A/c.7084G>A	{"RYR1": {"c.5441T>A": 1, "c.7084G>A": 1}}	\N
7823048	7815081	c.12149C>A/c.14387A>G	{"RYR1": {"c.12149C>A": 1, "c.14387A>G": 1}}	\N
7823049	7815081	c.13672C>T/c.14539G>C	{"RYR1": {"c.13672C>T": 1, "c.14539G>C": 1}}	\N
7823050	7815081	c.6617C>G/c.7528T>C	{"RYR1": {"c.6617C>G": 1, "c.7528T>C": 1}}	\N
7823051	7815081	c.7123G>A/c.8054C>T	{"RYR1": {"c.7123G>A": 1, "c.8054C>T": 1}}	\N
7823052	7815081	c.8638G>A/c.12700G>T	{"RYR1": {"c.8638G>A": 1, "c.12700G>T": 1}}	\N
7823053	7815081	c.3166G>C/c.6302T>A	{"RYR1": {"c.3166G>C": 1, "c.6302T>A": 1}}	\N
7823054	7815081	c.1565A>G/c.6377G>A	{"RYR1": {"c.1565A>G": 1, "c.6377G>A": 1}}	\N
7823055	7815081	c.1565A>C/c.12242C>T	{"RYR1": {"c.1565A>C": 1, "c.12242C>T": 1}}	\N
7823056	7815081	c.7036G>A/c.8926C>T	{"RYR1": {"c.7036G>A": 1, "c.8926C>T": 1}}	\N
7823057	7815081	c.7210G>A/c.7354C>T	{"RYR1": {"c.7210G>A": 1, "c.7354C>T": 1}}	\N
7823058	7815081	c.947G>T/c.14497C>T	{"RYR1": {"c.947G>T": 1, "c.14497C>T": 1}}	\N
7823059	7815081	c.7300G>A/c.14825G>T	{"RYR1": {"c.7300G>A": 1, "c.14825G>T": 1}}	\N
7823060	7815081	c.487C>T/c.6544A>T	{"RYR1": {"c.487C>T": 1, "c.6544A>T": 1}}	\N
7823061	7815081	c.1834G>C/c.11315G>A	{"RYR1": {"c.1834G>C": 1, "c.11315G>A": 1}}	\N
7823062	7815081	c.6617C>G/c.14558C>T	{"RYR1": {"c.6617C>G": 1, "c.14558C>T": 1}}	\N
7823063	7815081	c.8638G>A/c.12700G>C	{"RYR1": {"c.8638G>A": 1, "c.12700G>C": 1}}	\N
7823064	7815081	c.7036G>A/c.8290G>A	{"RYR1": {"c.7036G>A": 1, "c.8290G>A": 1}}	\N
7823065	7815081	c.9310G>A/c.11120G>T	{"RYR1": {"c.9310G>A": 1, "c.11120G>T": 1}}	\N
7823066	7815081	c.1597C>T/c.7292A>T	{"RYR1": {"c.1597C>T": 1, "c.7292A>T": 1}}	\N
7823067	7815081	c.3418C>T/c.7124G>C	{"RYR1": {"c.3418C>T": 1, "c.7124G>C": 1}}	\N
7823068	7815081	c.212C>A/c.11708G>A	{"RYR1": {"c.212C>A": 1, "c.11708G>A": 1}}	\N
7823069	7815081	c.11708G>A/c.11813G>A	{"RYR1": {"c.11708G>A": 1, "c.11813G>A": 1}}	\N
7823070	7815081	c.533A>G/c.8189A>G	{"RYR1": {"c.533A>G": 1, "c.8189A>G": 1}}	\N
7823071	7815081	c.3667G>A/c.7048G>A	{"RYR1": {"c.3667G>A": 1, "c.7048G>A": 1}}	\N
7823072	7815081	c.7372C>T/c.14581C>T	{"RYR1": {"c.7372C>T": 1, "c.14581C>T": 1}}	\N
7823073	7815081	c.641C>T/c.7048G>A	{"RYR1": {"c.641C>T": 1, "c.7048G>A": 1}}	\N
7823074	7815081	c.103T>C/c.10252A>G	{"RYR1": {"c.103T>C": 1, "c.10252A>G": 1}}	\N
7823075	7815081	c.7310C>T/c.13990T>C	{"RYR1": {"c.7310C>T": 1, "c.13990T>C": 1}}	\N
7823076	7815081	c.1100G>T/c.12700G>T	{"RYR1": {"c.1100G>T": 1, "c.12700G>T": 1}}	\N
7823077	7815081	c.7035C>A/c.13994_13995delTCinsCT	{"RYR1": {"c.7035C>A": 1, "c.13994_13995delTCinsCT": 1}}	\N
7823078	7815081	c.1021G>A/c.6742C>T	{"RYR1": {"c.1021G>A": 1, "c.6742C>T": 1}}	\N
7823079	7815081	c.251C>T/c.7063C>T	{"RYR1": {"c.251C>T": 1, "c.7063C>T": 1}}	\N
7823080	7815081	c.7358T>C/c.14422_14423delinsAA	{"RYR1": {"c.7358T>C": 1, "c.14422_14423delinsAA": 1}}	\N
7823081	7815081	c.7292A>T/c.7373G>A	{"RYR1": {"c.7292A>T": 1, "c.7373G>A": 1}}	\N
7823082	7815081	c.1615T>C/c.13672C>T	{"RYR1": {"c.1615T>C": 1, "c.13672C>T": 1}}	\N
7823083	7815081	c.1597C>A/c.7304G>A	{"RYR1": {"c.1597C>A": 1, "c.7304G>A": 1}}	\N
7823084	7815081	c.7282G>A/c.10229C>A	{"RYR1": {"c.7282G>A": 1, "c.10229C>A": 1}}	\N
7823085	7815081	c.2122G>A/c.14803G>A	{"RYR1": {"c.2122G>A": 1, "c.14803G>A": 1}}	\N
7823086	7815081	c.533A>G/c.12398A>G	{"RYR1": {"c.533A>G": 1, "c.12398A>G": 1}}	\N
7823087	7815081	c.1597C>A/c.7304G>T	{"RYR1": {"c.1597C>A": 1, "c.7304G>T": 1}}	\N
7823088	7815081	c.7035C>A/c.11126C>T	{"RYR1": {"c.7035C>A": 1, "c.11126C>T": 1}}	\N
7823089	7815081	c.7035C>A/c.14582G>A	{"RYR1": {"c.7035C>A": 1, "c.14582G>A": 1}}	\N
7823090	7815081	c.533A>G/c.8638G>A	{"RYR1": {"c.533A>G": 1, "c.8638G>A": 1}}	\N
7823091	7815081	c.1841G>T/c.8926C>T	{"RYR1": {"c.1841G>T": 1, "c.8926C>T": 1}}	\N
7823092	7815081	c.1597C>A/c.7076G>A	{"RYR1": {"c.1597C>A": 1, "c.7076G>A": 1}}	\N
7823093	7815081	c.680A>T/c.7300G>A	{"RYR1": {"c.680A>T": 1, "c.7300G>A": 1}}	\N
7823094	7815081	c.7360C>T/c.11416G>A	{"RYR1": {"c.7360C>T": 1, "c.11416G>A": 1}}	\N
7823095	7815081	c.6617C>T/c.7317G>C	{"RYR1": {"c.6617C>T": 1, "c.7317G>C": 1}}	\N
7823096	7815081	c.6617C>G/c.10237A>T	{"RYR1": {"c.6617C>G": 1, "c.10237A>T": 1}}	\N
7823097	7815081	c.1475G>A/c.14545G>A	{"RYR1": {"c.1475G>A": 1, "c.14545G>A": 1}}	\N
7823098	7815081	c.1615T>G/c.12383C>T	{"RYR1": {"c.1615T>G": 1, "c.12383C>T": 1}}	\N
7823099	7815081	c.742G>C/c.11120G>T	{"RYR1": {"c.742G>C": 1, "c.11120G>T": 1}}	\N
7823100	7815081	c.982C>T/c.5341T>C	{"RYR1": {"c.982C>T": 1, "c.5341T>C": 1}}	\N
7823101	7815081	c.1202G>T/c.6037A>C	{"RYR1": {"c.1202G>T": 1, "c.6037A>C": 1}}	\N
7823102	7815081	c.1100G>T/c.12700G>C	{"RYR1": {"c.1100G>T": 1, "c.12700G>C": 1}}	\N
7823103	7815081	c.251C>T/c.982C>T	{"RYR1": {"c.251C>T": 1, "c.982C>T": 1}}	\N
7823104	7815081	c.1565A>C/c.8638G>A	{"RYR1": {"c.1565A>C": 1, "c.8638G>A": 1}}	\N
7823105	7815081	c.6838G>A/c.14387A>G	{"RYR1": {"c.6838G>A": 1, "c.14387A>G": 1}}	\N
7823106	7815081	c.6599C>T/c.7042_7044delGAG	{"RYR1": {"c.6599C>T": 1, "c.7042_7044delGAG": 1}}	\N
7823107	7815081	c.533A>G/c.2537C>T	{"RYR1": {"c.533A>G": 1, "c.2537C>T": 1}}	\N
7823108	7815081	c.1597C>T/c.9652G>A	{"RYR1": {"c.1597C>T": 1, "c.9652G>A": 1}}	\N
7823109	7815081	c.463C>A/c.9635A>G	{"RYR1": {"c.463C>A": 1, "c.9635A>G": 1}}	\N
7823110	7815081	c.119G>C/c.1654C>T	{"RYR1": {"c.119G>C": 1, "c.1654C>T": 1}}	\N
7823111	7815081	c.488G>A/c.1589G>A	{"RYR1": {"c.488G>A": 1, "c.1589G>A": 1}}	\N
7823112	7815081	c.7060G>A/c.8926C>T	{"RYR1": {"c.7060G>A": 1, "c.8926C>T": 1}}	\N
7823113	7815081	c.6838G>A/c.14678G>A	{"RYR1": {"c.6838G>A": 1, "c.14678G>A": 1}}	\N
7823114	7815081	c.7304G>A/c.14582G>A	{"RYR1": {"c.7304G>A": 1, "c.14582G>A": 1}}	\N
7823115	7815081	c.11315G>A/c.12383C>T	{"RYR1": {"c.11315G>A": 1, "c.12383C>T": 1}}	\N
7823116	7815081	c.1209C>G/c.7007G>A	{"RYR1": {"c.1209C>G": 1, "c.7007G>A": 1}}	\N
7823117	7815081	c.1630G>T/c.14678G>A	{"RYR1": {"c.1630G>T": 1, "c.14678G>A": 1}}	\N
7823118	7815081	c.6838G>A/c.9850T>A	{"RYR1": {"c.6838G>A": 1, "c.9850T>A": 1}}	\N
7823119	7815081	c.1597C>T/c.7522C>G	{"RYR1": {"c.1597C>T": 1, "c.7522C>G": 1}}	\N
7823120	7815081	c.1201C>T/c.9850T>A	{"RYR1": {"c.1201C>T": 1, "c.9850T>A": 1}}	\N
7823121	7815081	c.1615T>C/c.9499C>T	{"RYR1": {"c.1615T>C": 1, "c.9499C>T": 1}}	\N
7823122	7815081	c.1565A>C/c.7097C>G	{"RYR1": {"c.1565A>C": 1, "c.7097C>G": 1}}	\N
7823123	7815081	c.1654C>T/c.12532G>A	{"RYR1": {"c.1654C>T": 1, "c.12532G>A": 1}}	\N
7823124	7815081	c.6478G>A/c.14209C>T	{"RYR1": {"c.6478G>A": 1, "c.14209C>T": 1}}	\N
7823125	7815081	c.3527C>T/c.14539G>C	{"RYR1": {"c.3527C>T": 1, "c.14539G>C": 1}}	\N
7823126	7815081	c.625G>A/c.6387C>G	{"RYR1": {"c.625G>A": 1, "c.6387C>G": 1}}	\N
7823127	7815081	c.103T>C/c.12413T>C	{"RYR1": {"c.103T>C": 1, "c.12413T>C": 1}}	\N
7823128	7815081	c.1565A>G/c.12398A>G	{"RYR1": {"c.1565A>G": 1, "c.12398A>G": 1}}	\N
7823129	7815081	c.7048G>A/c.14678G>A	{"RYR1": {"c.7048G>A": 1, "c.14678G>A": 1}}	\N
7823130	7815081	c.1202G>A/c.10043G>A	{"RYR1": {"c.1202G>A": 1, "c.10043G>A": 1}}	\N
7823131	7815081	c.529C>T/c.1144C>A	{"RYR1": {"c.529C>T": 1, "c.1144C>A": 1}}	\N
7823132	7815081	c.7199A>G/c.7282G>A	{"RYR1": {"c.7199A>G": 1, "c.7282G>A": 1}}	\N
7823133	7815081	c.982C>T/c.13672C>T	{"RYR1": {"c.982C>T": 1, "c.13672C>T": 1}}	\N
7823134	7815081	c.130C>T/c.1553T>C	{"RYR1": {"c.130C>T": 1, "c.1553T>C": 1}}	\N
7823135	7815081	c.11813G>A/c.14539G>C	{"RYR1": {"c.11813G>A": 1, "c.14539G>C": 1}}	\N
7823136	7815081	c.742G>A/c.11120G>T	{"RYR1": {"c.742G>A": 1, "c.11120G>T": 1}}	\N
7823137	7815081	c.7522C>T/c.14449A>T	{"RYR1": {"c.7522C>T": 1, "c.14449A>T": 1}}	\N
7823138	7815081	c.487C>T/c.3166G>A	{"RYR1": {"c.487C>T": 1, "c.3166G>A": 1}}	\N
7823139	7815081	c.1411C>T/c.14512C>G	{"RYR1": {"c.1411C>T": 1, "c.14512C>G": 1}}	\N
7823140	7815081	c.7360C>T/c.9635A>G	{"RYR1": {"c.7360C>T": 1, "c.9635A>G": 1}}	\N
7823141	7815081	c.1630G>T/c.1834G>C	{"RYR1": {"c.1630G>T": 1, "c.1834G>C": 1}}	\N
7823142	7815081	c.487C>T/c.8518C>T	{"RYR1": {"c.487C>T": 1, "c.8518C>T": 1}}	\N
7823143	7815081	c.11708G>A/c.12242C>T	{"RYR1": {"c.11708G>A": 1, "c.12242C>T": 1}}	\N
7823144	7815081	c.7292A>T/c.7373G>T	{"RYR1": {"c.7292A>T": 1, "c.7373G>T": 1}}	\N
7823145	7815081	c.533A>G/c.992_994dup	{"RYR1": {"c.533A>G": 1, "c.992_994dup": 1}}	\N
7823146	7815081	c.463C>A/c.1460T>C	{"RYR1": {"c.463C>A": 1, "c.1460T>C": 1}}	\N
7823147	7815081	c.12700G>T/c.13673G>A	{"RYR1": {"c.12700G>T": 1, "c.13673G>A": 1}}	\N
7823148	7815081	c.625G>A/c.11969G>T	{"RYR1": {"c.625G>A": 1, "c.11969G>T": 1}}	\N
7823149	7815081	c.6742C>T/c.7523G>A	{"RYR1": {"c.6742C>T": 1, "c.7523G>A": 1}}	\N
7823150	7815081	c.5183C>T/c.7760A>G	{"RYR1": {"c.5183C>T": 1, "c.7760A>G": 1}}	\N
7823151	7815081	c.7090T>G/c.14782A>G	{"RYR1": {"c.7090T>G": 1, "c.14782A>G": 1}}	\N
7823152	7815081	c.982C>T/c.14201G>A	{"RYR1": {"c.982C>T": 1, "c.14201G>A": 1}}	\N
7823153	7815081	c.7018T>C/c.7090T>G	{"RYR1": {"c.7018T>C": 1, "c.7090T>G": 1}}	\N
7823154	7815081	c.463C>A/c.4400A>G	{"RYR1": {"c.463C>A": 1, "c.4400A>G": 1}}	\N
7823155	7815081	c.7361G>A/c.14458G>T	{"RYR1": {"c.7361G>A": 1, "c.14458G>T": 1}}	\N
7823156	7815081	c.3166G>C/c.5890C>T	{"RYR1": {"c.3166G>C": 1, "c.5890C>T": 1}}	\N
7823157	7815081	c.7358T>C/c.7528T>C	{"RYR1": {"c.7358T>C": 1, "c.7528T>C": 1}}	\N
7823158	7815081	c.6388G>A/c.8026C>T	{"RYR1": {"c.6388G>A": 1, "c.8026C>T": 1}}	\N
7823159	7815081	c.7018T>C/c.7373G>A	{"RYR1": {"c.7018T>C": 1, "c.7373G>A": 1}}	\N
7823160	7815081	c.7042_7044delGAG/c.13918A>G	{"RYR1": {"c.13918A>G": 1, "c.7042_7044delGAG": 1}}	\N
7823161	7815081	c.7304G>A/c.14424C>A	{"RYR1": {"c.7304G>A": 1, "c.14424C>A": 1}}	\N
7823162	7815081	c.8026C>T/c.8290G>A	{"RYR1": {"c.8026C>T": 1, "c.8290G>A": 1}}	\N
7823163	7815081	c.103T>C/c.8005G>A	{"RYR1": {"c.103T>C": 1, "c.8005G>A": 1}}	\N
7823164	7815081	c.11708G>A/c.13760C>T	{"RYR1": {"c.11708G>A": 1, "c.13760C>T": 1}}	\N
7823165	7815081	c.7073T>A/c.12149C>A	{"RYR1": {"c.7073T>A": 1, "c.12149C>A": 1}}	\N
7823166	7815081	c.7310C>T/c.9848G>A	{"RYR1": {"c.7310C>T": 1, "c.9848G>A": 1}}	\N
7823167	7815081	c.742G>C/c.7199A>G	{"RYR1": {"c.742G>C": 1, "c.7199A>G": 1}}	\N
7823168	7815081	c.677T>A/c.7007G>A	{"RYR1": {"c.677T>A": 1, "c.7007G>A": 1}}	\N
7823169	7815081	c.14471T>C/c.14497C>T	{"RYR1": {"c.14471T>C": 1, "c.14497C>T": 1}}	\N
7823170	7815081	c.7300G>A/c.11120G>T	{"RYR1": {"c.7300G>A": 1, "c.11120G>T": 1}}	\N
7823171	7815081	c.7304G>T/c.8518C>T	{"RYR1": {"c.7304G>T": 1, "c.8518C>T": 1}}	\N
7823172	7815081	c.7361G>A/c.14458G>A	{"RYR1": {"c.7361G>A": 1, "c.14458G>A": 1}}	\N
7823173	7815081	c.1202G>T/c.14364+1G>T	{"RYR1": {"c.1202G>T": 1, "c.14364+1G>T": 1}}	\N
7823174	7815081	c.1597C>T/c.9676G>C	{"RYR1": {"c.1597C>T": 1, "c.9676G>C": 1}}	\N
7823175	7815081	c.6502G>A/c.14422_14423delinsAA	{"RYR1": {"c.6502G>A": 1, "c.14422_14423delinsAA": 1}}	\N
7823176	7815081	c.7124G>C/c.11314C>T	{"RYR1": {"c.7124G>C": 1, "c.11314C>T": 1}}	\N
7823177	7815081	c.1553T>C/c.6488G>A	{"RYR1": {"c.1553T>C": 1, "c.6488G>A": 1}}	\N
7823178	7815081	c.7084G>A/c.8518C>T	{"RYR1": {"c.7084G>A": 1, "c.8518C>T": 1}}	\N
7823179	7815081	c.2122G>A/c.7310C>T	{"RYR1": {"c.2122G>A": 1, "c.7310C>T": 1}}	\N
7823180	7815081	c.7073T>A/c.14627A>G	{"RYR1": {"c.7073T>A": 1, "c.14627A>G": 1}}	\N
7823181	7815081	c.625G>A/c.7372C>T	{"RYR1": {"c.625G>A": 1, "c.7372C>T": 1}}	\N
7823182	7815081	c.9758T>C/c.14627A>G	{"RYR1": {"c.9758T>C": 1, "c.14627A>G": 1}}	\N
7823183	7815081	c.6488G>T/c.11953T>C	{"RYR1": {"c.6488G>T": 1, "c.11953T>C": 1}}	\N
7823184	7815081	c.9310G>A/c.14825G>T	{"RYR1": {"c.9310G>A": 1, "c.14825G>T": 1}}	\N
7823185	7815081	c.14497C>T/c.14825G>T	{"RYR1": {"c.14497C>T": 1, "c.14825G>T": 1}}	\N
7823186	7815081	c.1553T>C/c.6488G>C	{"RYR1": {"c.1553T>C": 1, "c.6488G>C": 1}}	\N
7823187	7815081	c.463C>A/c.15059G>C	{"RYR1": {"c.463C>A": 1, "c.15059G>C": 1}}	\N
7823188	7815081	c.1021G>C/c.6742C>T	{"RYR1": {"c.1021G>C": 1, "c.6742C>T": 1}}	\N
7823189	7815081	c.13918A>G/c.14210G>A	{"RYR1": {"c.13918A>G": 1, "c.14210G>A": 1}}	\N
7823190	7815081	c.1565A>G/c.4400A>G	{"RYR1": {"c.1565A>G": 1, "c.4400A>G": 1}}	\N
7823191	7815081	c.1021G>A/c.1411C>T	{"RYR1": {"c.1021G>A": 1, "c.1411C>T": 1}}	\N
7823192	7815081	c.496G>A/c.7124G>C	{"RYR1": {"c.496G>A": 1, "c.7124G>C": 1}}	\N
7823193	7815081	c.625G>A/c.7360C>T	{"RYR1": {"c.625G>A": 1, "c.7360C>T": 1}}	\N
7823194	7815081	c.6617C>G/c.14422_14423delinsAA	{"RYR1": {"c.6617C>G": 1, "c.14422_14423delinsAA": 1}}	\N
7823195	7815081	c.11315G>A/c.14201G>A	{"RYR1": {"c.11315G>A": 1, "c.14201G>A": 1}}	\N
7823196	7815081	c.6743G>A/c.7358T>C	{"RYR1": {"c.6743G>A": 1, "c.7358T>C": 1}}	\N
7823197	7815081	c.1021G>A/c.2654G>A	{"RYR1": {"c.1021G>A": 1, "c.2654G>A": 1}}	\N
7823198	7815081	c.529C>T/c.11813G>A	{"RYR1": {"c.529C>T": 1, "c.11813G>A": 1}}	\N
7823199	7815081	c.7292A>T/c.7361G>A	{"RYR1": {"c.7292A>T": 1, "c.7361G>A": 1}}	\N
7823200	7815081	c.103T>C/c.178G>A	{"RYR1": {"c.103T>C": 1, "c.178G>A": 1}}	\N
7823201	7815081	c.7007G>A/c.7292A>T	{"RYR1": {"c.7007G>A": 1, "c.7292A>T": 1}}	\N
7823202	7815081	c.12149C>A/c.14582G>A	{"RYR1": {"c.12149C>A": 1, "c.14582G>A": 1}}	\N
7823203	7815081	c.529C>T/c.1024G>A	{"RYR1": {"c.529C>T": 1, "c.1024G>A": 1}}	\N
7823204	7815081	c.1615T>G/c.9499C>T	{"RYR1": {"c.1615T>G": 1, "c.9499C>T": 1}}	\N
7823205	7815081	c.7048G>A/c.7099G>A	{"RYR1": {"c.7048G>A": 1, "c.7099G>A": 1}}	\N
7823206	7815081	c.1100G>T/c.7084G>A	{"RYR1": {"c.1100G>T": 1, "c.7084G>A": 1}}	\N
7823207	7815081	c.5890C>T/c.14545G>A	{"RYR1": {"c.5890C>T": 1, "c.14545G>A": 1}}	\N
7823208	7815081	c.1565A>C/c.12398A>G	{"RYR1": {"c.1565A>C": 1, "c.12398A>G": 1}}	\N
7823209	7815081	c.742G>A/c.7199A>G	{"RYR1": {"c.742G>A": 1, "c.7199A>G": 1}}	\N
7823210	7815081	c.1630G>T/c.14387A>G	{"RYR1": {"c.1630G>T": 1, "c.14387A>G": 1}}	\N
7823211	7815081	c.7787C>T/c.8026C>T	{"RYR1": {"c.7787C>T": 1, "c.8026C>T": 1}}	\N
7823212	7815081	c.103T>C/c.178G>T	{"RYR1": {"c.103T>C": 1, "c.178G>T": 1}}	\N
7823213	7815081	c.51_53del/c.7354C>T	{"RYR1": {"c.7354C>T": 1, "c.51_53del": 1}}	\N
7823214	7815081	c.529C>T/c.6037A>C	{"RYR1": {"c.529C>T": 1, "c.6037A>C": 1}}	\N
7823215	7815081	c.7018T>C/c.7373G>T	{"RYR1": {"c.7018T>C": 1, "c.7373G>T": 1}}	\N
7823216	7815081	c.6617C>T/c.14509C>G	{"RYR1": {"c.6617C>T": 1, "c.14509C>G": 1}}	\N
7823217	7815081	c.5024T>C/c.7007G>A	{"RYR1": {"c.5024T>C": 1, "c.7007G>A": 1}}	\N
7823218	7815081	c.13994_13995delTCinsCT/c.14477C>T	{"RYR1": {"c.14477C>T": 1, "c.13994_13995delTCinsCT": 1}}	\N
7823219	7815081	c.9268G>A/c.14512C>G	{"RYR1": {"c.9268G>A": 1, "c.14512C>G": 1}}	\N
7823220	7815081	c.1100G>T/c.6612C>G	{"RYR1": {"c.1100G>T": 1, "c.6612C>G": 1}}	\N
7823221	7815081	c.7373G>A/c.14817C>A	{"RYR1": {"c.7373G>A": 1, "c.14817C>A": 1}}	\N
7823222	7815081	c.7199A>G/c.12149C>A	{"RYR1": {"c.7199A>G": 1, "c.12149C>A": 1}}	\N
7823223	7815081	c.7035C>A/c.13934G>A	{"RYR1": {"c.7035C>A": 1, "c.13934G>A": 1}}	\N
7823224	7815081	c.7522C>T/c.10237A>T	{"RYR1": {"c.7522C>T": 1, "c.10237A>T": 1}}	\N
7823225	7815081	c.641C>T/c.1589G>A	{"RYR1": {"c.641C>T": 1, "c.1589G>A": 1}}	\N
7823226	7815081	c.3166G>C/c.12355A>T	{"RYR1": {"c.3166G>C": 1, "c.12355A>T": 1}}	\N
7823227	7815081	c.7291G>T/c.13702C>G	{"RYR1": {"c.7291G>T": 1, "c.13702C>G": 1}}	\N
7823228	7815081	c.103T>C/c.625G>A	{"RYR1": {"c.103T>C": 1, "c.625G>A": 1}}	\N
7823229	7815081	c.742G>C/c.10556C>T	{"RYR1": {"c.742G>C": 1, "c.10556C>T": 1}}	\N
7823230	7815081	c.1589G>A/c.4747C>T	{"RYR1": {"c.1589G>A": 1, "c.4747C>T": 1}}	\N
7823231	7815081	c.103T>C/c.10750G>C	{"RYR1": {"c.103T>C": 1, "c.10750G>C": 1}}	\N
7823232	7815081	c.5186T>G/c.6628G>T	{"RYR1": {"c.5186T>G": 1, "c.6628G>T": 1}}	\N
7823233	7815081	c.7060G>A/c.13994_13995delTCinsCT	{"RYR1": {"c.7060G>A": 1, "c.13994_13995delTCinsCT": 1}}	\N
7823234	7815081	c.533A>C/c.1202G>T	{"RYR1": {"c.533A>C": 1, "c.1202G>T": 1}}	\N
7823235	7815081	c.7373G>T/c.12533G>T	{"RYR1": {"c.7373G>T": 1, "c.12533G>T": 1}}	\N
7823236	7815081	c.7310C>T/c.8054C>T	{"RYR1": {"c.7310C>T": 1, "c.8054C>T": 1}}	\N
7823237	7815081	c.7771C>T/c.11708G>A	{"RYR1": {"c.7771C>T": 1, "c.11708G>A": 1}}	\N
7823238	7815081	c.7123G>A/c.11723A>T	{"RYR1": {"c.7123G>A": 1, "c.11723A>T": 1}}	\N
7823239	7815081	c.1021G>C/c.2654G>A	{"RYR1": {"c.1021G>C": 1, "c.2654G>A": 1}}	\N
7823240	7815081	c.7035C>A/c.11748T>G	{"RYR1": {"c.7035C>A": 1, "c.11748T>G": 1}}	\N
7823241	7815081	c.7124G>C/c.14817C>A	{"RYR1": {"c.7124G>C": 1, "c.14817C>A": 1}}	\N
7823242	7815081	c.7522C>G/c.14918C>T	{"RYR1": {"c.7522C>G": 1, "c.14918C>T": 1}}	\N
7823243	7815081	c.1589G>A/c.10750G>C	{"RYR1": {"c.1589G>A": 1, "c.10750G>C": 1}}	\N
7823244	7815081	c.1615T>G/c.5341T>C	{"RYR1": {"c.1615T>G": 1, "c.5341T>C": 1}}	\N
7823245	7815081	c.533A>C/c.1202G>A	{"RYR1": {"c.533A>C": 1, "c.1202G>A": 1}}	\N
7823246	7815081	c.5183C>T/c.14813T>C	{"RYR1": {"c.5183C>T": 1, "c.14813T>C": 1}}	\N
7823247	7815081	c.6502G>A/c.14558C>T	{"RYR1": {"c.6502G>A": 1, "c.14558C>T": 1}}	\N
7823248	7815081	c.1589G>A/c.13913G>A	{"RYR1": {"c.1589G>A": 1, "c.13913G>A": 1}}	\N
7823249	7815081	c.463C>A/c.15060G>C	{"RYR1": {"c.463C>A": 1, "c.15060G>C": 1}}	\N
7823250	7815081	c.1565A>G/c.12121C>T	{"RYR1": {"c.1565A>G": 1, "c.12121C>T": 1}}	\N
7823251	7815081	c.1202G>T/c.6635T>A	{"RYR1": {"c.1202G>T": 1, "c.6635T>A": 1}}	\N
7823252	7815081	c.7292A>T/c.12700G>C	{"RYR1": {"c.7292A>T": 1, "c.12700G>C": 1}}	\N
7823253	7815081	c.529C>T/c.14387A>G	{"RYR1": {"c.529C>T": 1, "c.14387A>G": 1}}	\N
7823254	7815081	c.7360C>T/c.15059G>C	{"RYR1": {"c.7360C>T": 1, "c.15059G>C": 1}}	\N
7823255	7815081	c.533A>C/c.11969G>T	{"RYR1": {"c.533A>C": 1, "c.11969G>T": 1}}	\N
7823256	7815081	c.982C>T/c.12383C>T	{"RYR1": {"c.982C>T": 1, "c.12383C>T": 1}}	\N
7823257	7815081	c.7291G>T/c.14678G>A	{"RYR1": {"c.7291G>T": 1, "c.14678G>A": 1}}	\N
7823258	7815081	c.7310C>T/c.9649T>C	{"RYR1": {"c.7310C>T": 1, "c.9649T>C": 1}}	\N
7823259	7815081	c.7292A>T/c.12700G>T	{"RYR1": {"c.7292A>T": 1, "c.12700G>T": 1}}	\N
7823260	7815081	c.7076G>A/c.13505A>G	{"RYR1": {"c.7076G>A": 1, "c.13505A>G": 1}}	\N
7823261	7815081	c.7373G>T/c.10043G>A	{"RYR1": {"c.7373G>T": 1, "c.10043G>A": 1}}	\N
7823262	7815081	c.1565A>C/c.6377G>A	{"RYR1": {"c.1565A>C": 1, "c.6377G>A": 1}}	\N
7823263	7815081	c.742G>A/c.10556C>T	{"RYR1": {"c.742G>A": 1, "c.10556C>T": 1}}	\N
7823264	7815081	c.6617C>G/c.13702C>G	{"RYR1": {"c.6617C>G": 1, "c.13702C>G": 1}}	\N
7823265	7815081	c.7007G>A/c.7075C>T	{"RYR1": {"c.7007G>A": 1, "c.7075C>T": 1}}	\N
7823266	7815081	c.5890C>T/c.7124G>C	{"RYR1": {"c.5890C>T": 1, "c.7124G>C": 1}}	\N
7823267	7815081	c.7523G>A/c.13918A>G	{"RYR1": {"c.7523G>A": 1, "c.13918A>G": 1}}	\N
7823268	7815081	c.1565A>C/c.4400A>G	{"RYR1": {"c.1565A>C": 1, "c.4400A>G": 1}}	\N
7823269	7815081	c.3095G>A/c.14209C>T	{"RYR1": {"c.3095G>A": 1, "c.14209C>T": 1}}	\N
7823270	7815081	c.7291G>T/c.14581C>T	{"RYR1": {"c.7291G>T": 1, "c.14581C>T": 1}}	\N
7823271	7815081	c.529C>T/c.7292A>T	{"RYR1": {"c.529C>T": 1, "c.7292A>T": 1}}	\N
7823272	7815081	c.10237A>T/c.11969G>T	{"RYR1": {"c.10237A>T": 1, "c.11969G>T": 1}}	\N
7823273	7815081	c.7063C>T/c.7760A>G	{"RYR1": {"c.7063C>T": 1, "c.7760A>G": 1}}	\N
7823274	7815081	c.1553T>C/c.6488G>T	{"RYR1": {"c.1553T>C": 1, "c.6488G>T": 1}}	\N
7823275	7815081	c.7291G>T/c.9850T>A	{"RYR1": {"c.7291G>T": 1, "c.9850T>A": 1}}	\N
7823276	7815081	c.103T>C/c.11518G>A	{"RYR1": {"c.103T>C": 1, "c.11518G>A": 1}}	\N
7823277	7815081	c.6599C>T/c.11708G>A	{"RYR1": {"c.6599C>T": 1, "c.11708G>A": 1}}	\N
7823278	7815081	c.1841G>T/c.2924G>A	{"RYR1": {"c.1841G>T": 1, "c.2924G>A": 1}}	\N
7823279	7815081	c.3172G>A/c.7523G>A	{"RYR1": {"c.3172G>A": 1, "c.7523G>A": 1}}	\N
7823280	7815081	c.4775C>T/c.7879G>C	{"RYR1": {"c.4775C>T": 1, "c.7879G>C": 1}}	\N
7823281	7815081	c.982C>T/c.11518G>A	{"RYR1": {"c.982C>T": 1, "c.11518G>A": 1}}	\N
7823282	7815081	c.1201C>A/c.7123G>A	{"RYR1": {"c.1201C>A": 1, "c.7123G>A": 1}}	\N
7823283	7815081	c.103T>C/c.13913G>A	{"RYR1": {"c.103T>C": 1, "c.13913G>A": 1}}	\N
7823284	7815081	c.7063C>T/c.10042C>T	{"RYR1": {"c.7063C>T": 1, "c.10042C>T": 1}}	\N
7823285	7815081	c.497A>G/c.1202G>A	{"RYR1": {"c.497A>G": 1, "c.1202G>A": 1}}	\N
7823286	7815081	c.6502G>A/c.7487C>T	{"RYR1": {"c.6502G>A": 1, "c.7487C>T": 1}}	\N
7823287	7815081	c.131G>A/c.11708G>A	{"RYR1": {"c.131G>A": 1, "c.11708G>A": 1}}	\N
7823288	7815081	c.7199A>G/c.14627A>G	{"RYR1": {"c.7199A>G": 1, "c.14627A>G": 1}}	\N
7823289	7815081	c.533A>G/c.5441T>A	{"RYR1": {"c.533A>G": 1, "c.5441T>A": 1}}	\N
7823290	7815081	c.1202G>T/c.10042C>T	{"RYR1": {"c.1202G>T": 1, "c.10042C>T": 1}}	\N
7823291	7815081	c.1589G>A/c.11518G>A	{"RYR1": {"c.1589G>A": 1, "c.11518G>A": 1}}	\N
7823292	7815081	c.1597C>A/c.7523G>A	{"RYR1": {"c.1597C>A": 1, "c.7523G>A": 1}}	\N
7823293	7815081	c.7018T>C/c.7361G>A	{"RYR1": {"c.7018T>C": 1, "c.7361G>A": 1}}	\N
7823294	7815081	c.6640G>A/c.7300G>A	{"RYR1": {"c.6640G>A": 1, "c.7300G>A": 1}}	\N
7823295	7815081	c.7300G>A/c.9848G>A	{"RYR1": {"c.7300G>A": 1, "c.9848G>A": 1}}	\N
7823296	7815081	c.7354C>T/c.14581C>T	{"RYR1": {"c.7354C>T": 1, "c.14581C>T": 1}}	\N
7823297	7815081	c.14477C>T/c.14813T>C	{"RYR1": {"c.14477C>T": 1, "c.14813T>C": 1}}	\N
7823298	7815081	c.7360C>T/c.15060G>C	{"RYR1": {"c.7360C>T": 1, "c.15060G>C": 1}}	\N
7823299	7815081	c.1565A>C/c.10043G>A	{"RYR1": {"c.1565A>C": 1, "c.10043G>A": 1}}	\N
7823300	7815081	c.6628G>T/c.14818G>A	{"RYR1": {"c.6628G>T": 1, "c.14818G>A": 1}}	\N
7823301	7815081	c.3127C>T/c.14627A>G	{"RYR1": {"c.3127C>T": 1, "c.14627A>G": 1}}	\N
7823302	7815081	c.97A>G/c.3667G>A	{"RYR1": {"c.97A>G": 1, "c.3667G>A": 1}}	\N
7823303	7815081	c.7076G>A/c.7879G>A	{"RYR1": {"c.7076G>A": 1, "c.7879G>A": 1}}	\N
7823304	7815081	c.7361G>A/c.12532G>A	{"RYR1": {"c.7361G>A": 1, "c.12532G>A": 1}}	\N
7823305	7815081	c.2654G>A/c.14477C>T	{"RYR1": {"c.2654G>A": 1, "c.14477C>T": 1}}	\N
7823306	7815081	c.1615T>C/c.10229C>A	{"RYR1": {"c.1615T>C": 1, "c.10229C>A": 1}}	\N
7823307	7815081	c.3095G>A/c.7042_7044delGAG	{"RYR1": {"c.3095G>A": 1, "c.7042_7044delGAG": 1}}	\N
7823308	7815081	c.463C>A/c.6377G>A	{"RYR1": {"c.463C>A": 1, "c.6377G>A": 1}}	\N
7823309	7815081	c.529C>T/c.11126C>T	{"RYR1": {"c.529C>T": 1, "c.11126C>T": 1}}	\N
7823310	7815081	c.6544A>T/c.6617C>G	{"RYR1": {"c.6544A>T": 1, "c.6617C>G": 1}}	\N
7823311	7815081	c.1630G>T/c.7292A>T	{"RYR1": {"c.1630G>T": 1, "c.7292A>T": 1}}	\N
7823312	7815081	c.946C>T/c.7007G>A	{"RYR1": {"c.946C>T": 1, "c.7007G>A": 1}}	\N
7823313	7815081	c.1201C>A/c.7358T>C	{"RYR1": {"c.1201C>A": 1, "c.7358T>C": 1}}	\N
7823314	7815081	c.6488G>C/c.7487C>T	{"RYR1": {"c.6488G>C": 1, "c.7487C>T": 1}}	\N
7823315	7815081	c.6612C>G/c.7777C>G	{"RYR1": {"c.6612C>G": 1, "c.7777C>G": 1}}	\N
7823316	7815081	c.6544A>T/c.6617C>T	{"RYR1": {"c.6544A>T": 1, "c.6617C>T": 1}}	\N
7823317	7815081	c.1565A>C/c.12121C>T	{"RYR1": {"c.1565A>C": 1, "c.12121C>T": 1}}	\N
7823318	7815081	c.1021G>A/c.12383C>T	{"RYR1": {"c.1021G>A": 1, "c.12383C>T": 1}}	\N
7823319	7815081	c.1021G>A/c.5341T>C	{"RYR1": {"c.1021G>A": 1, "c.5341T>C": 1}}	\N
7823320	7815081	c.1565A>G/c.7385C>T	{"RYR1": {"c.1565A>G": 1, "c.7385C>T": 1}}	\N
7823321	7815081	c.7282G>A/c.14186A>C	{"RYR1": {"c.7282G>A": 1, "c.14186A>C": 1}}	\N
7823322	7815081	c.7304G>T/c.14270G>A	{"RYR1": {"c.7304G>T": 1, "c.14270G>A": 1}}	\N
7823323	7815081	c.1021G>A/c.8198G>A	{"RYR1": {"c.1021G>A": 1, "c.8198G>A": 1}}	\N
7823324	7815081	c.1202G>A/c.6388G>A	{"RYR1": {"c.1202G>A": 1, "c.6388G>A": 1}}	\N
7823325	7815081	c.6488G>T/c.6743G>A	{"RYR1": {"c.6488G>T": 1, "c.6743G>A": 1}}	\N
7823326	7815081	c.1021G>C/c.2122G>A	{"RYR1": {"c.1021G>C": 1, "c.2122G>A": 1}}	\N
7823327	7815081	c.1202G>T/c.7760A>G	{"RYR1": {"c.1202G>T": 1, "c.7760A>G": 1}}	\N
7823328	7815081	c.982C>T/c.5186T>G	{"RYR1": {"c.982C>T": 1, "c.5186T>G": 1}}	\N
7823329	7815081	c.7358T>C/c.10237A>T	{"RYR1": {"c.7358T>C": 1, "c.10237A>T": 1}}	\N
7823330	7815081	c.11969G>T/c.14567C>G	{"RYR1": {"c.11969G>T": 1, "c.14567C>G": 1}}	\N
7823331	7815081	c.12413T>C/c.14545G>A	{"RYR1": {"c.12413T>C": 1, "c.14545G>A": 1}}	\N
7823332	7815081	c.1144C>A/c.14803G>A	{"RYR1": {"c.1144C>A": 1, "c.14803G>A": 1}}	\N
7823333	7815081	c.1201C>A/c.12149C>A	{"RYR1": {"c.1201C>A": 1, "c.12149C>A": 1}}	\N
7823334	7815081	c.6037A>C/c.6612C>G	{"RYR1": {"c.6037A>C": 1, "c.6612C>G": 1}}	\N
7823335	7815081	c.9310G>A/c.14126C>T	{"RYR1": {"c.9310G>A": 1, "c.14126C>T": 1}}	\N
7823336	7815081	c.6617C>T/c.7528T>C	{"RYR1": {"c.6617C>T": 1, "c.7528T>C": 1}}	\N
7823337	7815081	c.7787C>T/c.12149C>A	{"RYR1": {"c.7787C>T": 1, "c.12149C>A": 1}}	\N
7823338	7815081	c.1615T>G/c.9848G>A	{"RYR1": {"c.1615T>G": 1, "c.9848G>A": 1}}	\N
7823339	7815081	c.7354C>T/c.14678G>A	{"RYR1": {"c.7354C>T": 1, "c.14678G>A": 1}}	\N
7823340	7815081	c.1589G>A/c.3172G>A	{"RYR1": {"c.1589G>A": 1, "c.3172G>A": 1}}	\N
7823341	7815081	c.463C>A/c.1453A>G	{"RYR1": {"c.463C>A": 1, "c.1453A>G": 1}}	\N
7823342	7815081	c.742G>A/c.12553G>A	{"RYR1": {"c.742G>A": 1, "c.12553G>A": 1}}	\N
7823343	7815081	c.3172G>A/c.6502G>A	{"RYR1": {"c.3172G>A": 1, "c.6502G>A": 1}}	\N
7823344	7815081	c.7300G>A/c.8527T>C	{"RYR1": {"c.7300G>A": 1, "c.8527T>C": 1}}	\N
7823345	7815081	c.6349G>C/c.8189A>G	{"RYR1": {"c.6349G>C": 1, "c.8189A>G": 1}}	\N
7823346	7815081	c.1024G>A/c.1202G>T	{"RYR1": {"c.1024G>A": 1, "c.1202G>T": 1}}	\N
7823347	7815081	c.9152G>A/c.9310G>A	{"RYR1": {"c.9152G>A": 1, "c.9310G>A": 1}}	\N
7823348	7815081	c.5183C>T/c.6304G>C	{"RYR1": {"c.5183C>T": 1, "c.6304G>C": 1}}	\N
7823349	7815081	c.6742C>T/c.7522C>T	{"RYR1": {"c.6742C>T": 1, "c.7522C>T": 1}}	\N
7823350	7815081	c.8026C>T/c.12532G>A	{"RYR1": {"c.8026C>T": 1, "c.12532G>A": 1}}	\N
7823351	7815081	c.7291G>A/c.8518C>T	{"RYR1": {"c.7291G>A": 1, "c.8518C>T": 1}}	\N
7823352	7815081	c.1021G>A/c.2122G>A	{"RYR1": {"c.1021G>A": 1, "c.2122G>A": 1}}	\N
7823353	7815081	c.488G>T/c.7097C>G	{"RYR1": {"c.488G>T": 1, "c.7097C>G": 1}}	\N
7823354	7815081	c.1553T>C/c.7063C>T	{"RYR1": {"c.1553T>C": 1, "c.7063C>T": 1}}	\N
7823355	7815081	c.6612C>G/c.14524G>A	{"RYR1": {"c.6612C>G": 1, "c.14524G>A": 1}}	\N
7823356	7815081	c.5341T>C/c.6628G>T	{"RYR1": {"c.5341T>C": 1, "c.6628G>T": 1}}	\N
7823357	7815081	c.11708G>A/c.14817C>A	{"RYR1": {"c.11708G>A": 1, "c.14817C>A": 1}}	\N
7823358	7815081	c.947G>T/c.1630G>T	{"RYR1": {"c.947G>T": 1, "c.1630G>T": 1}}	\N
7823359	7815081	c.6628G>T/c.7771C>G	{"RYR1": {"c.6628G>T": 1, "c.7771C>G": 1}}	\N
7823360	7815081	c.7090T>G/c.7099G>A	{"RYR1": {"c.7090T>G": 1, "c.7099G>A": 1}}	\N
7823361	7815081	c.1021G>C/c.12383C>T	{"RYR1": {"c.1021G>C": 1, "c.12383C>T": 1}}	\N
7823362	7815081	c.488G>A/c.11969G>T	{"RYR1": {"c.488G>A": 1, "c.11969G>T": 1}}	\N
7823363	7815081	c.1021G>C/c.5341T>C	{"RYR1": {"c.1021G>C": 1, "c.5341T>C": 1}}	\N
7823364	7815081	c.7523G>A/c.12848A>T	{"RYR1": {"c.7523G>A": 1, "c.12848A>T": 1}}	\N
7823365	7815081	c.5183C>T/c.7385C>T	{"RYR1": {"c.5183C>T": 1, "c.7385C>T": 1}}	\N
7823366	7815081	c.6488G>T/c.6548G>A	{"RYR1": {"c.6488G>T": 1, "c.6548G>A": 1}}	\N
7823367	7815081	c.7076G>A/c.13760C>T	{"RYR1": {"c.7076G>A": 1, "c.13760C>T": 1}}	\N
7823368	7815081	c.1565A>G/c.10043G>A	{"RYR1": {"c.1565A>G": 1, "c.10043G>A": 1}}	\N
7823369	7815081	c.2050G>C/c.7043A>G	{"RYR1": {"c.2050G>C": 1, "c.7043A>G": 1}}	\N
7823370	7815081	c.6488G>T/c.14509C>G	{"RYR1": {"c.6488G>T": 1, "c.14509C>G": 1}}	\N
7823371	7815081	c.992_994dup/c.6612C>G	{"RYR1": {"c.6612C>G": 1, "c.992_994dup": 1}}	\N
7823372	7815081	c.5890C>T/c.7063C>T	{"RYR1": {"c.5890C>T": 1, "c.7063C>T": 1}}	\N
7823373	7815081	c.7007G>A/c.7760A>G	{"RYR1": {"c.7007G>A": 1, "c.7760A>G": 1}}	\N
7823374	7815081	c.742G>C/c.12553G>A	{"RYR1": {"c.742G>C": 1, "c.12553G>A": 1}}	\N
7823375	7815081	c.7043A>G/c.12532G>A	{"RYR1": {"c.7043A>G": 1, "c.12532G>A": 1}}	\N
7823376	7815081	c.7036G>A/c.15060G>C	{"RYR1": {"c.7036G>A": 1, "c.15060G>C": 1}}	\N
7823377	7815081	c.1589G>A/c.12413T>C	{"RYR1": {"c.1589G>A": 1, "c.12413T>C": 1}}	\N
7823378	7815081	c.7085A>G/c.7090T>G	{"RYR1": {"c.7085A>G": 1, "c.7090T>G": 1}}	\N
7823379	7815081	c.38T>G/c.12028G>A	{"RYR1": {"c.38T>G": 1, "c.12028G>A": 1}}	\N
7823380	7815081	c.7063C>T/c.14364+1G>T	{"RYR1": {"c.7063C>T": 1, "c.14364+1G>T": 1}}	\N
7823381	7815081	c.6502G>A/c.8005G>A	{"RYR1": {"c.6502G>A": 1, "c.8005G>A": 1}}	\N
7823382	7815081	c.2122G>A/c.14477C>T	{"RYR1": {"c.2122G>A": 1, "c.14477C>T": 1}}	\N
7823383	7815081	c.6612C>G/c.14968A>G	{"RYR1": {"c.6612C>G": 1, "c.14968A>G": 1}}	\N
7823384	7815081	c.1597C>A/c.7522C>T	{"RYR1": {"c.1597C>A": 1, "c.7522C>T": 1}}	\N
7823385	7815081	c.1024G>A/c.7291G>A	{"RYR1": {"c.1024G>A": 1, "c.7291G>A": 1}}	\N
7823386	7815081	c.493G>A/c.6349G>C	{"RYR1": {"c.493G>A": 1, "c.6349G>C": 1}}	\N
7823387	7815081	c.6502G>A/c.7528T>C	{"RYR1": {"c.6502G>A": 1, "c.7528T>C": 1}}	\N
7823388	7815081	c.7358T>C/c.11953T>C	{"RYR1": {"c.7358T>C": 1, "c.11953T>C": 1}}	\N
7823389	7815081	c.1615T>G/c.10229C>A	{"RYR1": {"c.1615T>G": 1, "c.10229C>A": 1}}	\N
7823390	7815081	c.11958C>G/c.14512C>G	{"RYR1": {"c.11958C>G": 1, "c.14512C>G": 1}}	\N
7823391	7815081	c.1201C>T/c.7317G>C	{"RYR1": {"c.1201C>T": 1, "c.7317G>C": 1}}	\N
7823392	7815081	c.14201G>A/c.14539G>C	{"RYR1": {"c.14201G>A": 1, "c.14539G>C": 1}}	\N
7823393	7815081	c.6612C>G/c.8600T>A	{"RYR1": {"c.6612C>G": 1, "c.8600T>A": 1}}	\N
7823394	7815081	c.1144C>A/c.14539G>C	{"RYR1": {"c.1144C>A": 1, "c.14539G>C": 1}}	\N
7823395	7815081	c.529C>T/c.7075C>T	{"RYR1": {"c.529C>T": 1, "c.7075C>T": 1}}	\N
7823396	7815081	c.3418C>T/c.6838G>A	{"RYR1": {"c.3418C>T": 1, "c.6838G>A": 1}}	\N
7823397	7815081	c.11126C>T/c.14627A>G	{"RYR1": {"c.11126C>T": 1, "c.14627A>G": 1}}	\N
7823398	7815081	c.7528T>C/c.9310G>A	{"RYR1": {"c.7528T>C": 1, "c.9310G>A": 1}}	\N
7823399	7815081	c.982C>T/c.9649T>C	{"RYR1": {"c.982C>T": 1, "c.9649T>C": 1}}	\N
7823400	7815081	c.1834G>C/c.7373G>T	{"RYR1": {"c.1834G>C": 1, "c.7373G>T": 1}}	\N
7823401	7815081	c.742G>A/c.14126C>T	{"RYR1": {"c.742G>A": 1, "c.14126C>T": 1}}	\N
7823402	7815081	c.2996G>A/c.7523G>A	{"RYR1": {"c.2996G>A": 1, "c.7523G>A": 1}}	\N
7823403	7815081	c.1615T>C/c.9848G>A	{"RYR1": {"c.1615T>C": 1, "c.9848G>A": 1}}	\N
7823404	7815081	c.6488G>T/c.7528T>C	{"RYR1": {"c.6488G>T": 1, "c.7528T>C": 1}}	\N
7823405	7815081	c.6628G>T/c.12242C>T	{"RYR1": {"c.6628G>T": 1, "c.12242C>T": 1}}	\N
7823406	7815081	c.7060G>A/c.15060G>C	{"RYR1": {"c.7060G>A": 1, "c.15060G>C": 1}}	\N
7823407	7815081	c.488G>T/c.1460T>C	{"RYR1": {"c.488G>T": 1, "c.1460T>C": 1}}	\N
7823408	7815081	c.6617C>T/c.9268G>A	{"RYR1": {"c.6617C>T": 1, "c.9268G>A": 1}}	\N
7823409	7815081	c.982C>T/c.2654G>A	{"RYR1": {"c.982C>T": 1, "c.2654G>A": 1}}	\N
7823410	7815081	c.1589G>A/c.12115A>T	{"RYR1": {"c.1589G>A": 1, "c.12115A>T": 1}}	\N
7823411	7815081	c.103T>C/c.6302T>A	{"RYR1": {"c.103T>C": 1, "c.6302T>A": 1}}	\N
7823412	7815081	c.7048G>A/c.7085A>G	{"RYR1": {"c.7048G>A": 1, "c.7085A>G": 1}}	\N
7823413	7815081	c.1597C>T/c.13934G>A	{"RYR1": {"c.1597C>T": 1, "c.13934G>A": 1}}	\N
7823414	7815081	c.982C>T/c.14639T>C	{"RYR1": {"c.982C>T": 1, "c.14639T>C": 1}}	\N
7823415	7815081	c.7073T>A/c.7282G>A	{"RYR1": {"c.7073T>A": 1, "c.7282G>A": 1}}	\N
7823416	7815081	c.982C>T/c.11132C>T	{"RYR1": {"c.982C>T": 1, "c.11132C>T": 1}}	\N
7823417	7815081	c.463C>A/c.7771C>G	{"RYR1": {"c.463C>A": 1, "c.7771C>G": 1}}	\N
7823418	7815081	c.5890C>T/c.6838G>A	{"RYR1": {"c.5890C>T": 1, "c.6838G>A": 1}}	\N
7823419	7815081	c.7304G>A/c.12848A>T	{"RYR1": {"c.7304G>A": 1, "c.12848A>T": 1}}	\N
7823420	7815081	c.8026C>T/c.14458G>A	{"RYR1": {"c.8026C>T": 1, "c.14458G>A": 1}}	\N
7823421	7815081	c.130C>T/c.12413T>C	{"RYR1": {"c.130C>T": 1, "c.12413T>C": 1}}	\N
7823422	7815081	c.14497C>T/c.14524G>A	{"RYR1": {"c.14497C>T": 1, "c.14524G>A": 1}}	\N
7823423	7815081	c.7304G>T/c.14424C>A	{"RYR1": {"c.7304G>T": 1, "c.14424C>A": 1}}	\N
7823424	7815081	c.8005G>A/c.9310G>A	{"RYR1": {"c.8005G>A": 1, "c.9310G>A": 1}}	\N
7823425	7815081	c.463C>A/c.7771C>T	{"RYR1": {"c.463C>A": 1, "c.7771C>T": 1}}	\N
7823426	7815081	c.178G>A/c.7042_7044delGAG	{"RYR1": {"c.178G>A": 1, "c.7042_7044delGAG": 1}}	\N
7823427	7815081	c.7292A>T/c.7300G>A	{"RYR1": {"c.7292A>T": 1, "c.7300G>A": 1}}	\N
7823428	7815081	c.7522C>T/c.14524G>A	{"RYR1": {"c.7522C>T": 1, "c.14524G>A": 1}}	\N
7823429	7815081	c.7310C>T/c.9499C>T	{"RYR1": {"c.7310C>T": 1, "c.9499C>T": 1}}	\N
7823430	7815081	c.7036G>A/c.15059G>C	{"RYR1": {"c.7036G>A": 1, "c.15059G>C": 1}}	\N
7823431	7815081	c.7123G>A/c.9499C>T	{"RYR1": {"c.7123G>A": 1, "c.9499C>T": 1}}	\N
7823432	7815081	c.1475G>A/c.1565A>C	{"RYR1": {"c.1475G>A": 1, "c.1565A>C": 1}}	\N
7823433	7815081	c.488G>T/c.12242C>T	{"RYR1": {"c.488G>T": 1, "c.12242C>T": 1}}	\N
7823434	7815081	c.7304G>T/c.13994_13995delTCinsCT	{"RYR1": {"c.7304G>T": 1, "c.13994_13995delTCinsCT": 1}}	\N
7823435	7815081	c.6617C>T/c.14558C>T	{"RYR1": {"c.6617C>T": 1, "c.14558C>T": 1}}	\N
7823436	7815081	c.1100G>A/c.12700G>C	{"RYR1": {"c.1100G>A": 1, "c.12700G>C": 1}}	\N
7823437	7815081	c.1021G>C/c.8198G>A	{"RYR1": {"c.1021G>C": 1, "c.8198G>A": 1}}	\N
7823438	7815081	c.1475G>A/c.1565A>G	{"RYR1": {"c.1475G>A": 1, "c.1565A>G": 1}}	\N
7823439	7815081	c.12700G>C/c.13673G>A	{"RYR1": {"c.12700G>C": 1, "c.13673G>A": 1}}	\N
7823440	7815081	c.6488G>T/c.14422_14423delinsAA	{"RYR1": {"c.6488G>T": 1, "c.14422_14423delinsAA": 1}}	\N
7823441	7815081	c.7879G>C/c.14509C>G	{"RYR1": {"c.7879G>C": 1, "c.14509C>G": 1}}	\N
7823442	7815081	c.1100G>A/c.12700G>T	{"RYR1": {"c.1100G>A": 1, "c.12700G>T": 1}}	\N
7823443	7815081	c.103T>C/c.1553T>C	{"RYR1": {"c.103T>C": 1, "c.1553T>C": 1}}	\N
7823444	7815081	c.1654C>T/c.5441T>A	{"RYR1": {"c.1654C>T": 1, "c.5441T>A": 1}}	\N
7823445	7815081	c.1475G>A/c.3166G>C	{"RYR1": {"c.1475G>A": 1, "c.3166G>C": 1}}	\N
7823446	7815081	c.11086G>C/c.14545G>A	{"RYR1": {"c.11086G>C": 1, "c.14545G>A": 1}}	\N
7823447	7815081	c.742G>C/c.14126C>T	{"RYR1": {"c.742G>C": 1, "c.14126C>T": 1}}	\N
7823448	7815081	c.7007G>A/c.11813G>A	{"RYR1": {"c.7007G>A": 1, "c.11813G>A": 1}}	\N
7823449	7815081	c.1024G>A/c.7291G>T	{"RYR1": {"c.1024G>A": 1, "c.7291G>T": 1}}	\N
7823450	7815081	c.5033A>G/c.7879G>C	{"RYR1": {"c.5033A>G": 1, "c.7879G>C": 1}}	\N
7823451	7815081	c.1202G>A/c.6037A>C	{"RYR1": {"c.1202G>A": 1, "c.6037A>C": 1}}	\N
7823452	7815081	c.1553T>C/c.7282G>A	{"RYR1": {"c.1553T>C": 1, "c.7282G>A": 1}}	\N
7823453	7815081	c.8026C>T/c.14458G>T	{"RYR1": {"c.8026C>T": 1, "c.14458G>T": 1}}	\N
7823454	7815081	c.641C>T/c.7090T>G	{"RYR1": {"c.641C>T": 1, "c.7090T>G": 1}}	\N
7823455	7815081	c.6838G>A/c.13702C>G	{"RYR1": {"c.6838G>A": 1, "c.13702C>G": 1}}	\N
7823456	7815081	c.6847A>C/c.11708G>A	{"RYR1": {"c.6847A>C": 1, "c.11708G>A": 1}}	\N
7823457	7815081	c.1100G>A/c.7084G>A	{"RYR1": {"c.1100G>A": 1, "c.7084G>A": 1}}	\N
7823458	7815081	c.463C>A/c.4763C>T	{"RYR1": {"c.463C>A": 1, "c.4763C>T": 1}}	\N
7823459	7815081	c.14627A>G/c.14825G>T	{"RYR1": {"c.14627A>G": 1, "c.14825G>T": 1}}	\N
7823460	7815081	c.6388G>A/c.7354C>T	{"RYR1": {"c.6388G>A": 1, "c.7354C>T": 1}}	\N
7823461	7815081	c.7124G>C/c.13760C>T	{"RYR1": {"c.7124G>C": 1, "c.13760C>T": 1}}	\N
7823462	7815081	c.6640G>A/c.7372C>T	{"RYR1": {"c.6640G>A": 1, "c.7372C>T": 1}}	\N
7823463	7815081	c.463C>A/c.12242C>T	{"RYR1": {"c.463C>A": 1, "c.12242C>T": 1}}	\N
7823464	7815081	c.1834G>C/c.7361G>A	{"RYR1": {"c.1834G>C": 1, "c.7361G>A": 1}}	\N
7823465	7815081	c.947G>T/c.6487C>T	{"RYR1": {"c.947G>T": 1, "c.6487C>T": 1}}	\N
7823466	7815081	c.529C>T/c.9676G>C	{"RYR1": {"c.529C>T": 1, "c.9676G>C": 1}}	\N
7823467	7815081	c.6838G>A/c.7292A>T	{"RYR1": {"c.6838G>A": 1, "c.7292A>T": 1}}	\N
7823468	7815081	c.7304G>T/c.14582G>A	{"RYR1": {"c.7304G>T": 1, "c.14582G>A": 1}}	\N
7823469	7815081	c.7291G>A/c.14581C>T	{"RYR1": {"c.7291G>A": 1, "c.14581C>T": 1}}	\N
7823470	7815081	c.467G>A/c.14210G>A	{"RYR1": {"c.467G>A": 1, "c.14210G>A": 1}}	\N
7823471	7815081	c.6387C>G/c.7199A>G	{"RYR1": {"c.6387C>G": 1, "c.7199A>G": 1}}	\N
7823472	7815081	c.533A>G/c.12532G>A	{"RYR1": {"c.533A>G": 1, "c.12532G>A": 1}}	\N
7823473	7815081	c.9758T>C/c.14545G>A	{"RYR1": {"c.9758T>C": 1, "c.14545G>A": 1}}	\N
7823474	7815081	c.6640G>A/c.7360C>T	{"RYR1": {"c.6640G>A": 1, "c.7360C>T": 1}}	\N
7823475	7815081	c.6488G>C/c.11953T>C	{"RYR1": {"c.6488G>C": 1, "c.11953T>C": 1}}	\N
7823476	7815081	c.7358T>C/c.13702C>G	{"RYR1": {"c.7358T>C": 1, "c.13702C>G": 1}}	\N
7823477	7815081	c.51_53del/c.8026C>T	{"RYR1": {"c.8026C>T": 1, "c.51_53del": 1}}	\N
7823478	7815081	c.1615T>C/c.9649T>C	{"RYR1": {"c.1615T>C": 1, "c.9649T>C": 1}}	\N
7823479	7815081	c.7060G>A/c.9635A>G	{"RYR1": {"c.7060G>A": 1, "c.9635A>G": 1}}	\N
7823480	7815081	c.742G>A/c.6757C>T	{"RYR1": {"c.742G>A": 1, "c.6757C>T": 1}}	\N
7823481	7815081	c.1100G>T/c.7060G>A	{"RYR1": {"c.1100G>T": 1, "c.7060G>A": 1}}	\N
7823482	7815081	c.526G>A/c.14497C>T	{"RYR1": {"c.526G>A": 1, "c.14497C>T": 1}}	\N
7823483	7815081	c.1021G>C/c.14186A>C	{"RYR1": {"c.1021G>C": 1, "c.14186A>C": 1}}	\N
7823484	7815081	c.1021G>C/c.7073T>A	{"RYR1": {"c.1021G>C": 1, "c.7073T>A": 1}}	\N
7823485	7815081	c.7771C>G/c.11708G>A	{"RYR1": {"c.7771C>G": 1, "c.11708G>A": 1}}	\N
7823486	7815081	c.1841G>T/c.14458G>A	{"RYR1": {"c.1841G>T": 1, "c.14458G>A": 1}}	\N
7823487	7815081	c.6487C>T/c.14968A>G	{"RYR1": {"c.6487C>T": 1, "c.14968A>G": 1}}	\N
7823488	7815081	c.6488G>C/c.6671G>A	{"RYR1": {"c.6488G>C": 1, "c.6671G>A": 1}}	\N
7823489	7815081	c.1565A>G/c.7097C>G	{"RYR1": {"c.1565A>G": 1, "c.7097C>G": 1}}	\N
7823490	7815081	c.6387C>G/c.9356G>A	{"RYR1": {"c.6387C>G": 1, "c.9356G>A": 1}}	\N
7823491	7815081	c.4747C>T/c.6628G>T	{"RYR1": {"c.4747C>T": 1, "c.6628G>T": 1}}	\N
7823492	7815081	c.1201C>G/c.12149C>A	{"RYR1": {"c.1201C>G": 1, "c.12149C>A": 1}}	\N
7823493	7815081	c.1459C>G/c.9310G>A	{"RYR1": {"c.1459C>G": 1, "c.9310G>A": 1}}	\N
7823494	7815081	c.7777C>G/c.14477C>T	{"RYR1": {"c.7777C>G": 1, "c.14477C>T": 1}}	\N
7823495	7815081	c.1841G>T/c.14458G>T	{"RYR1": {"c.1841G>T": 1, "c.14458G>T": 1}}	\N
7823496	7815081	c.13505A>G/c.14803G>A	{"RYR1": {"c.13505A>G": 1, "c.14803G>A": 1}}	\N
7823497	7815081	c.7372C>T/c.9850T>A	{"RYR1": {"c.7372C>T": 1, "c.9850T>A": 1}}	\N
7823498	7815081	c.6544A>T/c.7123G>A	{"RYR1": {"c.6544A>T": 1, "c.7123G>A": 1}}	\N
7823499	7815081	c.1630G>T/c.9676G>C	{"RYR1": {"c.1630G>T": 1, "c.9676G>C": 1}}	\N
7823500	7815081	c.1834G>C/c.7373G>A	{"RYR1": {"c.1834G>C": 1, "c.7373G>A": 1}}	\N
7823501	7815081	c.1202G>A/c.10042C>T	{"RYR1": {"c.1202G>A": 1, "c.10042C>T": 1}}	\N
7823502	7815081	c.14567C>G/c.14627A>G	{"RYR1": {"c.14567C>G": 1, "c.14627A>G": 1}}	\N
7823503	7815081	c.7032G>C/c.14497C>T	{"RYR1": {"c.7032G>C": 1, "c.14497C>T": 1}}	\N
7823504	7815081	c.455C>A/c.6612C>G	{"RYR1": {"c.455C>A": 1, "c.6612C>G": 1}}	\N
7823505	7815081	c.7282G>A/c.11120G>T	{"RYR1": {"c.7282G>A": 1, "c.11120G>T": 1}}	\N
7823506	7815081	c.1201C>G/c.7358T>C	{"RYR1": {"c.1201C>G": 1, "c.7358T>C": 1}}	\N
7823507	7815081	c.7361G>A/c.14364+1G>T	{"RYR1": {"c.7361G>A": 1, "c.14364+1G>T": 1}}	\N
7823508	7815081	c.9848G>A/c.11708G>A	{"RYR1": {"c.9848G>A": 1, "c.11708G>A": 1}}	\N
7823509	7815081	c.7879G>C/c.14558C>T	{"RYR1": {"c.7879G>C": 1, "c.14558C>T": 1}}	\N
7823510	7815081	c.8198G>A/c.11315G>A	{"RYR1": {"c.8198G>A": 1, "c.11315G>A": 1}}	\N
7823511	7815081	c.1840C>T/c.9868G>A	{"RYR1": {"c.1840C>T": 1, "c.9868G>A": 1}}	\N
7823512	7815081	c.6487C>T/c.8600T>A	{"RYR1": {"c.6487C>T": 1, "c.8600T>A": 1}}	\N
7823513	7815081	c.6488G>A/c.11953T>C	{"RYR1": {"c.6488G>A": 1, "c.11953T>C": 1}}	\N
7823514	7815081	c.982C>T/c.7073T>A	{"RYR1": {"c.982C>T": 1, "c.7073T>A": 1}}	\N
7823515	7815081	c.7310C>T/c.14879T>A	{"RYR1": {"c.7310C>T": 1, "c.14879T>A": 1}}	\N
7823516	7815081	c.11969G>T/c.13918A>G	{"RYR1": {"c.11969G>T": 1, "c.13918A>G": 1}}	\N
7823517	7815081	c.7060G>A/c.15059G>C	{"RYR1": {"c.7060G>A": 1, "c.15059G>C": 1}}	\N
7823518	7815081	c.9652G>A/c.14497C>T	{"RYR1": {"c.9652G>A": 1, "c.14497C>T": 1}}	\N
7823519	7815081	c.7373G>A/c.7771C>T	{"RYR1": {"c.7373G>A": 1, "c.7771C>T": 1}}	\N
7823520	7815081	c.7307G>A/c.7372C>T	{"RYR1": {"c.7307G>A": 1, "c.7372C>T": 1}}	\N
7823521	7815081	c.6488G>A/c.6671G>A	{"RYR1": {"c.6488G>A": 1, "c.6671G>A": 1}}	\N
7823522	7815081	c.7373G>A/c.7771C>G	{"RYR1": {"c.7373G>A": 1, "c.7771C>G": 1}}	\N
7823523	7815081	c.1021G>A/c.14186A>C	{"RYR1": {"c.1021G>A": 1, "c.14186A>C": 1}}	\N
7823524	7815081	c.14509C>G/c.14627A>G	{"RYR1": {"c.14509C>G": 1, "c.14627A>G": 1}}	\N
7823525	7815081	c.982C>T/c.10252A>G	{"RYR1": {"c.982C>T": 1, "c.10252A>G": 1}}	\N
7823526	7815081	c.488G>T/c.1453A>G	{"RYR1": {"c.488G>T": 1, "c.1453A>G": 1}}	\N
7823527	7815081	c.5890C>T/c.7522C>T	{"RYR1": {"c.5890C>T": 1, "c.7522C>T": 1}}	\N
7823528	7815081	c.7879G>A/c.14209C>T	{"RYR1": {"c.7879G>A": 1, "c.14209C>T": 1}}	\N
7823529	7815081	c.463C>A/c.7097C>G	{"RYR1": {"c.463C>A": 1, "c.7097C>G": 1}}	\N
7823530	7815081	c.12383C>T/c.12700G>C	{"RYR1": {"c.12383C>T": 1, "c.12700G>C": 1}}	\N
7823531	7815081	c.6671G>A/c.7123G>A	{"RYR1": {"c.6671G>A": 1, "c.7123G>A": 1}}	\N
7823532	7815081	c.7007G>A/c.11958C>G	{"RYR1": {"c.7007G>A": 1, "c.11958C>G": 1}}	\N
7823533	7815081	c.7124G>C/c.14782A>G	{"RYR1": {"c.7124G>C": 1, "c.14782A>G": 1}}	\N
7823534	7815081	c.12383C>T/c.12700G>T	{"RYR1": {"c.12383C>T": 1, "c.12700G>T": 1}}	\N
7823535	7815081	c.533A>C/c.1615T>C	{"RYR1": {"c.533A>C": 1, "c.1615T>C": 1}}	\N
7823536	7815081	c.6488G>T/c.12848A>T	{"RYR1": {"c.6488G>T": 1, "c.12848A>T": 1}}	\N
7823537	7815081	c.641C>T/c.1841G>T	{"RYR1": {"c.641C>T": 1, "c.1841G>T": 1}}	\N
7823538	7815081	c.533A>C/c.1615T>G	{"RYR1": {"c.533A>C": 1, "c.1615T>G": 1}}	\N
7823539	7815081	c.12149C>A/c.14678G>A	{"RYR1": {"c.12149C>A": 1, "c.14678G>A": 1}}	\N
7823540	7815081	c.652G>A/c.14210G>A	{"RYR1": {"c.652G>A": 1, "c.14210G>A": 1}}	\N
7823541	7815081	c.7124G>C/c.12533G>T	{"RYR1": {"c.7124G>C": 1, "c.12533G>T": 1}}	\N
7823542	7815081	c.1597C>T/c.7075C>T	{"RYR1": {"c.1597C>T": 1, "c.7075C>T": 1}}	\N
7823543	7815081	c.487C>T/c.11958C>G	{"RYR1": {"c.487C>T": 1, "c.11958C>G": 1}}	\N
7823544	7815081	c.9310G>A/c.14968A>G	{"RYR1": {"c.9310G>A": 1, "c.14968A>G": 1}}	\N
7823545	7815081	c.7042_7044delGAG/c.14422_14423delinsAA	{"RYR1": {"c.7042_7044delGAG": 1, "c.14422_14423delinsAA": 1}}	\N
7823546	7815081	c.3166G>C/c.12689T>G	{"RYR1": {"c.3166G>C": 1, "c.12689T>G": 1}}	\N
7823547	7815081	c.1024G>A/c.1202G>A	{"RYR1": {"c.1024G>A": 1, "c.1202G>A": 1}}	\N
7823548	7815081	c.6628G>T/c.7771C>T	{"RYR1": {"c.6628G>T": 1, "c.7771C>T": 1}}	\N
7823549	7815081	c.1589G>A/c.5890C>T	{"RYR1": {"c.1589G>A": 1, "c.5890C>T": 1}}	\N
7823550	7815081	c.496G>A/c.6838G>A	{"RYR1": {"c.496G>A": 1, "c.6838G>A": 1}}	\N
7823551	7815081	c.2537C>T/c.6617C>T	{"RYR1": {"c.2537C>T": 1, "c.6617C>T": 1}}	\N
7823552	7815081	c.7300G>A/c.14186A>C	{"RYR1": {"c.7300G>A": 1, "c.14186A>C": 1}}	\N
7823553	7815081	c.529C>T/c.9652G>A	{"RYR1": {"c.529C>T": 1, "c.9652G>A": 1}}	\N
7823554	7815081	c.533A>G/c.13505A>G	{"RYR1": {"c.533A>G": 1, "c.13505A>G": 1}}	\N
7823555	7815081	c.1100G>A/c.6612C>G	{"RYR1": {"c.1100G>A": 1, "c.6612C>G": 1}}	\N
7823556	7815081	c.1597C>T/c.14387A>G	{"RYR1": {"c.1597C>T": 1, "c.14387A>G": 1}}	\N
7823557	7815081	c.1615T>G/c.9649T>C	{"RYR1": {"c.1615T>G": 1, "c.9649T>C": 1}}	\N
7823558	7815081	c.2537C>T/c.6617C>G	{"RYR1": {"c.2537C>T": 1, "c.6617C>G": 1}}	\N
7823559	7815081	c.1841G>T/c.12532G>A	{"RYR1": {"c.1841G>T": 1, "c.12532G>A": 1}}	\N
7823560	7815081	c.7307G>A/c.7360C>T	{"RYR1": {"c.7307G>A": 1, "c.7360C>T": 1}}	\N
7823561	7815081	c.1100G>A/c.7879G>C	{"RYR1": {"c.1100G>A": 1, "c.7879G>C": 1}}	\N
7823562	7815081	c.7007G>A/c.9676G>C	{"RYR1": {"c.7007G>A": 1, "c.9676G>C": 1}}	\N
7823563	7815081	c.6617C>T/c.14422_14423delinsAA	{"RYR1": {"c.6617C>T": 1, "c.14422_14423delinsAA": 1}}	\N
7823564	7815081	c.14209C>T/c.14471T>C	{"RYR1": {"c.14209C>T": 1, "c.14471T>C": 1}}	\N
7823565	7815081	c.11132C>T/c.14545G>A	{"RYR1": {"c.11132C>T": 1, "c.14545G>A": 1}}	\N
7823566	7815081	c.1565A>G/c.12242C>T	{"RYR1": {"c.1565A>G": 1, "c.12242C>T": 1}}	\N
7823567	7815081	c.3095G>A/c.11708G>A	{"RYR1": {"c.3095G>A": 1, "c.11708G>A": 1}}	\N
7823568	7815081	c.11315G>A/c.12553G>A	{"RYR1": {"c.11315G>A": 1, "c.12553G>A": 1}}	\N
7823569	7815081	c.7043A>G/c.10556C>T	{"RYR1": {"c.7043A>G": 1, "c.10556C>T": 1}}	\N
7823570	7815081	c.5033A>G/c.12700G>C	{"RYR1": {"c.5033A>G": 1, "c.12700G>C": 1}}	\N
7823571	7815081	c.1597C>T/c.12355A>T	{"RYR1": {"c.1597C>T": 1, "c.12355A>T": 1}}	\N
7823572	7815081	c.6628G>T/c.14051T>C	{"RYR1": {"c.6628G>T": 1, "c.14051T>C": 1}}	\N
7823573	7815081	c.6617C>G/c.11953T>C	{"RYR1": {"c.6617C>G": 1, "c.11953T>C": 1}}	\N
7823574	7815081	c.7042_7044delGAG/c.8654C>G	{"RYR1": {"c.8654C>G": 1, "c.7042_7044delGAG": 1}}	\N
7823575	7815081	c.14197T>G/c.14497C>T	{"RYR1": {"c.14197T>G": 1, "c.14497C>T": 1}}	\N
7823576	7815081	c.463C>A/c.4775C>T	{"RYR1": {"c.463C>A": 1, "c.4775C>T": 1}}	\N
7823577	7815081	c.130C>T/c.3172G>A	{"RYR1": {"c.130C>T": 1, "c.3172G>A": 1}}	\N
7823578	7815081	c.1841G>T/c.13505A>G	{"RYR1": {"c.1841G>T": 1, "c.13505A>G": 1}}	\N
7823579	7815081	c.6387C>G/c.8729C>T	{"RYR1": {"c.6387C>G": 1, "c.8729C>T": 1}}	\N
7823580	7815081	c.1453A>G/c.7035C>A	{"RYR1": {"c.1453A>G": 1, "c.7035C>A": 1}}	\N
7823581	7815081	c.6617C>T/c.8654C>G	{"RYR1": {"c.6617C>T": 1, "c.8654C>G": 1}}	\N
7823582	7815081	c.5033A>G/c.12700G>T	{"RYR1": {"c.5033A>G": 1, "c.12700G>T": 1}}	\N
7823583	7815081	c.7089C>G/c.14512C>G	{"RYR1": {"c.7089C>G": 1, "c.14512C>G": 1}}	\N
7823584	7815081	c.7360C>T/c.9868G>A	{"RYR1": {"c.7360C>T": 1, "c.9868G>A": 1}}	\N
7823585	7815081	c.6838G>A/c.10237A>T	{"RYR1": {"c.6838G>A": 1, "c.10237A>T": 1}}	\N
7823586	7815081	c.6349G>C/c.9152G>A	{"RYR1": {"c.6349G>C": 1, "c.9152G>A": 1}}	\N
7823587	7815081	c.533A>G/c.2996G>A	{"RYR1": {"c.533A>G": 1, "c.2996G>A": 1}}	\N
7823588	7815081	c.1553T>C/c.7124G>C	{"RYR1": {"c.1553T>C": 1, "c.7124G>C": 1}}	\N
7823589	7815081	c.1475G>A/c.14918C>T	{"RYR1": {"c.1475G>A": 1, "c.14918C>T": 1}}	\N
7823590	7815081	c.1422G>T/c.12149C>A	{"RYR1": {"c.1422G>T": 1, "c.12149C>A": 1}}	\N
7823591	7815081	c.103T>C/c.3172G>A	{"RYR1": {"c.103T>C": 1, "c.3172G>A": 1}}	\N
7823592	7815081	c.1630G>T/c.9652G>A	{"RYR1": {"c.1630G>T": 1, "c.9652G>A": 1}}	\N
7823593	7815081	c.742G>C/c.6757C>T	{"RYR1": {"c.742G>C": 1, "c.6757C>T": 1}}	\N
7823594	7815081	c.7317G>C/c.11708G>A	{"RYR1": {"c.7317G>C": 1, "c.11708G>A": 1}}	\N
7823595	7815081	c.533A>C/c.6387C>G	{"RYR1": {"c.533A>C": 1, "c.6387C>G": 1}}	\N
7823596	7815081	c.51_53del/c.982C>T	{"RYR1": {"c.982C>T": 1, "c.51_53del": 1}}	\N
7823597	7815081	c.103T>C/c.5890C>T	{"RYR1": {"c.103T>C": 1, "c.5890C>T": 1}}	\N
7823598	7815081	c.7354C>T/c.8518C>T	{"RYR1": {"c.7354C>T": 1, "c.8518C>T": 1}}	\N
7823599	7815081	c.1021G>A/c.7073T>A	{"RYR1": {"c.1021G>A": 1, "c.7073T>A": 1}}	\N
7823600	7815081	c.6488G>T/c.14558C>T	{"RYR1": {"c.6488G>T": 1, "c.14558C>T": 1}}	\N
7823601	7815081	c.38T>G/c.13505A>G	{"RYR1": {"c.38T>G": 1, "c.13505A>G": 1}}	\N
7823602	7815081	c.7090T>G/c.14364+1G>T	{"RYR1": {"c.7090T>G": 1, "c.14364+1G>T": 1}}	\N
7823603	7815081	c.2537C>T/c.6488G>T	{"RYR1": {"c.2537C>T": 1, "c.6488G>T": 1}}	\N
7823604	7815081	c.7018T>C/c.9310G>A	{"RYR1": {"c.7018T>C": 1, "c.9310G>A": 1}}	\N
7823605	7815081	c.3166G>C/c.6671G>A	{"RYR1": {"c.3166G>C": 1, "c.6671G>A": 1}}	\N
7823606	7815081	c.7060G>A/c.10043G>A	{"RYR1": {"c.7060G>A": 1, "c.10043G>A": 1}}	\N
7823607	7815081	c.6387C>G/c.14201G>A	{"RYR1": {"c.6387C>G": 1, "c.14201G>A": 1}}	\N
7823608	7815081	c.7292A>T/c.7360C>T	{"RYR1": {"c.7292A>T": 1, "c.7360C>T": 1}}	\N
7823609	7815081	c.1597C>T/c.3095G>A	{"RYR1": {"c.1597C>T": 1, "c.3095G>A": 1}}	\N
7823610	7815081	c.1453A>G/c.6387C>G	{"RYR1": {"c.1453A>G": 1, "c.6387C>G": 1}}	\N
7823611	7815081	c.7097C>G/c.7879G>C	{"RYR1": {"c.7097C>G": 1, "c.7879G>C": 1}}	\N
7823612	7815081	c.7307G>A/c.12700G>T	{"RYR1": {"c.7307G>A": 1, "c.12700G>T": 1}}	\N
7823613	7815081	c.1630G>T/c.13918A>G	{"RYR1": {"c.1630G>T": 1, "c.13918A>G": 1}}	\N
7823614	7815081	c.3095G>A/c.6502G>A	{"RYR1": {"c.3095G>A": 1, "c.6502G>A": 1}}	\N
7823615	7815081	c.1565A>G/c.14458G>T	{"RYR1": {"c.1565A>G": 1, "c.14458G>T": 1}}	\N
7823616	7815081	c.7124G>C/c.12242C>T	{"RYR1": {"c.7124G>C": 1, "c.12242C>T": 1}}	\N
7823617	7815081	c.7307G>A/c.7310C>T	{"RYR1": {"c.7307G>A": 1, "c.7310C>T": 1}}	\N
7823618	7815081	c.1565A>G/c.14458G>A	{"RYR1": {"c.1565A>G": 1, "c.14458G>A": 1}}	\N
7823619	7815081	c.1021G>A/c.14879T>A	{"RYR1": {"c.1021G>A": 1, "c.14879T>A": 1}}	\N
7823620	7815081	c.1100G>T/c.14539G>C	{"RYR1": {"c.1100G>T": 1, "c.14539G>C": 1}}	\N
7823621	7815081	c.7522C>T/c.8527T>C	{"RYR1": {"c.7522C>T": 1, "c.8527T>C": 1}}	\N
7823622	7815081	c.7282G>A/c.14639T>C	{"RYR1": {"c.7282G>A": 1, "c.14639T>C": 1}}	\N
7823623	7815081	c.1422G>T/c.14627A>G	{"RYR1": {"c.1422G>T": 1, "c.14627A>G": 1}}	\N
7823624	7815081	c.6488G>C/c.6548G>A	{"RYR1": {"c.6488G>C": 1, "c.6548G>A": 1}}	\N
7823625	7815081	c.7307G>A/c.12700G>C	{"RYR1": {"c.7307G>A": 1, "c.12700G>C": 1}}	\N
7823626	7815081	c.7032G>C/c.8026C>T	{"RYR1": {"c.7032G>C": 1, "c.8026C>T": 1}}	\N
7823627	7815081	c.1201C>A/c.14545G>A	{"RYR1": {"c.1201C>A": 1, "c.14545G>A": 1}}	\N
7823628	7815081	c.6488G>T/c.7317G>C	{"RYR1": {"c.6488G>T": 1, "c.7317G>C": 1}}	\N
7823629	7815081	c.7063C>T/c.14693T>C	{"RYR1": {"c.7063C>T": 1, "c.14693T>C": 1}}	\N
7823630	7815081	c.7523G>A/c.14582G>A	{"RYR1": {"c.7523G>A": 1, "c.14582G>A": 1}}	\N
7823631	7815081	c.6743G>A/c.7063C>T	{"RYR1": {"c.6743G>A": 1, "c.7063C>T": 1}}	\N
7823632	7815081	c.1201C>T/c.13702C>G	{"RYR1": {"c.1201C>T": 1, "c.13702C>G": 1}}	\N
7823633	7815081	c.463C>A/c.7385C>T	{"RYR1": {"c.463C>A": 1, "c.7385C>T": 1}}	\N
7823634	7815081	c.7090T>G/c.15060G>C	{"RYR1": {"c.7090T>G": 1, "c.15060G>C": 1}}	\N
7823635	7815081	c.12700G>T/c.13672C>T	{"RYR1": {"c.12700G>T": 1, "c.13672C>T": 1}}	\N
7823636	7815081	c.97A>G/c.6640G>A	{"RYR1": {"c.97A>G": 1, "c.6640G>A": 1}}	\N
7823637	7815081	c.10891G>T/c.11315G>A	{"RYR1": {"c.10891G>T": 1, "c.11315G>A": 1}}	\N
7823638	7815081	c.2537C>T/c.6488G>C	{"RYR1": {"c.2537C>T": 1, "c.6488G>C": 1}}	\N
7823639	7815081	c.463C>A/c.8290G>A	{"RYR1": {"c.463C>A": 1, "c.8290G>A": 1}}	\N
7823640	7815081	c.2537C>T/c.6488G>A	{"RYR1": {"c.2537C>T": 1, "c.6488G>A": 1}}	\N
7823641	7815081	c.641C>T/c.6628G>T	{"RYR1": {"c.641C>T": 1, "c.6628G>T": 1}}	\N
7823642	7815081	c.526G>A/c.3166G>C	{"RYR1": {"c.526G>A": 1, "c.3166G>C": 1}}	\N
7823643	7815081	c.529C>T/c.1422G>T	{"RYR1": {"c.529C>T": 1, "c.1422G>T": 1}}	\N
7823644	7815081	c.7060G>A/c.7085A>G	{"RYR1": {"c.7060G>A": 1, "c.7085A>G": 1}}	\N
7823645	7815081	c.7354C>T/c.14582G>A	{"RYR1": {"c.7354C>T": 1, "c.14582G>A": 1}}	\N
7823646	7815081	c.7097C>G/c.7372C>T	{"RYR1": {"c.7097C>G": 1, "c.7372C>T": 1}}	\N
7823647	7815081	c.8189A>G/c.11315G>A	{"RYR1": {"c.8189A>G": 1, "c.11315G>A": 1}}	\N
7823648	7815081	c.6847A>C/c.8026C>T	{"RYR1": {"c.6847A>C": 1, "c.8026C>T": 1}}	\N
7823649	7815081	c.6502G>A/c.12115A>T	{"RYR1": {"c.6502G>A": 1, "c.12115A>T": 1}}	\N
7823650	7815081	c.1459C>G/c.7090T>G	{"RYR1": {"c.1459C>G": 1, "c.7090T>G": 1}}	\N
7823651	7815081	c.1144C>A/c.6612C>G	{"RYR1": {"c.1144C>A": 1, "c.6612C>G": 1}}	\N
7823652	7815081	c.9268G>A/c.14477C>T	{"RYR1": {"c.9268G>A": 1, "c.14477C>T": 1}}	\N
7823653	7815081	c.7042_7044delGAG/c.11947C>T	{"RYR1": {"c.11947C>T": 1, "c.7042_7044delGAG": 1}}	\N
7823654	7815081	c.38T>G/c.6304G>C	{"RYR1": {"c.38T>G": 1, "c.6304G>C": 1}}	\N
7823655	7815081	c.1422G>T/c.6617C>T	{"RYR1": {"c.1422G>T": 1, "c.6617C>T": 1}}	\N
7823656	7815081	c.14512C>G/c.14814C>G	{"RYR1": {"c.14512C>G": 1, "c.14814C>G": 1}}	\N
7823657	7815081	c.7210G>A/c.8026C>T	{"RYR1": {"c.7210G>A": 1, "c.8026C>T": 1}}	\N
7823658	7815081	c.7292A>T/c.7372C>T	{"RYR1": {"c.7292A>T": 1, "c.7372C>T": 1}}	\N
7823659	7815081	c.1422G>T/c.6617C>G	{"RYR1": {"c.1422G>T": 1, "c.6617C>G": 1}}	\N
7823660	7815081	c.7036G>A/c.7097C>G	{"RYR1": {"c.7036G>A": 1, "c.7097C>G": 1}}	\N
7823661	7815081	c.7076G>A/c.7385C>T	{"RYR1": {"c.7076G>A": 1, "c.7385C>T": 1}}	\N
7823662	7815081	c.7304G>A/c.11416G>A	{"RYR1": {"c.7304G>A": 1, "c.11416G>A": 1}}	\N
7823663	7815081	c.7048G>A/c.14581C>T	{"RYR1": {"c.7048G>A": 1, "c.14581C>T": 1}}	\N
7823664	7815081	c.8638G>A/c.9310G>A	{"RYR1": {"c.8638G>A": 1, "c.9310G>A": 1}}	\N
7823665	7815081	c.13672C>T/c.14803G>A	{"RYR1": {"c.13672C>T": 1, "c.14803G>A": 1}}	\N
7823666	7815081	c.7282G>A/c.12553G>A	{"RYR1": {"c.7282G>A": 1, "c.12553G>A": 1}}	\N
7823667	7815081	c.7304G>A/c.9868G>A	{"RYR1": {"c.7304G>A": 1, "c.9868G>A": 1}}	\N
7823668	7815081	c.7355G>C/c.9310G>A	{"RYR1": {"c.7355G>C": 1, "c.9310G>A": 1}}	\N
7823669	7815081	c.130C>T/c.10556C>T	{"RYR1": {"c.130C>T": 1, "c.10556C>T": 1}}	\N
7823670	7815081	c.8054C>T/c.14803G>A	{"RYR1": {"c.8054C>T": 1, "c.14803G>A": 1}}	\N
7823671	7815081	c.6628G>T/c.12121C>T	{"RYR1": {"c.6628G>T": 1, "c.12121C>T": 1}}	\N
7823672	7815081	c.14210G>A/c.14270G>A	{"RYR1": {"c.14210G>A": 1, "c.14270G>A": 1}}	\N
7823673	7815081	c.3127C>T/c.14545G>A	{"RYR1": {"c.3127C>T": 1, "c.14545G>A": 1}}	\N
7823674	7815081	c.6487C>T/c.7777C>G	{"RYR1": {"c.6487C>T": 1, "c.7777C>G": 1}}	\N
7823675	7815081	c.2537C>T/c.3166G>C	{"RYR1": {"c.2537C>T": 1, "c.3166G>C": 1}}	\N
7823676	7815081	c.38T>G/c.6635T>A	{"RYR1": {"c.38T>G": 1, "c.6635T>A": 1}}	\N
7823677	7815081	c.7084G>A/c.10891G>T	{"RYR1": {"c.7084G>A": 1, "c.10891G>T": 1}}	\N
7823678	7815081	c.6488G>C/c.10237A>T	{"RYR1": {"c.6488G>C": 1, "c.10237A>T": 1}}	\N
7823679	7815081	c.1021G>C/c.14524G>A	{"RYR1": {"c.1021G>C": 1, "c.14524G>A": 1}}	\N
7823680	7815081	c.1841G>T/c.8189A>G	{"RYR1": {"c.1841G>T": 1, "c.8189A>G": 1}}	\N
7823681	7815081	c.1202G>T/c.13505A>G	{"RYR1": {"c.1202G>T": 1, "c.13505A>G": 1}}	\N
7823682	7815081	c.947G>T/c.14918C>T	{"RYR1": {"c.947G>T": 1, "c.14918C>T": 1}}	\N
7823683	7815081	c.1565A>C/c.14458G>T	{"RYR1": {"c.1565A>C": 1, "c.14458G>T": 1}}	\N
7823684	7815081	c.497A>G/c.1201C>T	{"RYR1": {"c.497A>G": 1, "c.1201C>T": 1}}	\N
7823685	7815081	c.7076G>A/c.14817C>A	{"RYR1": {"c.7076G>A": 1, "c.14817C>A": 1}}	\N
7823686	7815081	c.497A>G/c.7035C>A	{"RYR1": {"c.497A>G": 1, "c.7035C>A": 1}}	\N
7823687	7815081	c.982C>T/c.8054C>T	{"RYR1": {"c.982C>T": 1, "c.8054C>T": 1}}	\N
7823688	7815081	c.51_53del/c.12149C>A	{"RYR1": {"c.12149C>A": 1, "c.51_53del": 1}}	\N
7823689	7815081	c.6387C>G/c.9649T>C	{"RYR1": {"c.6387C>G": 1, "c.9649T>C": 1}}	\N
7823690	7815081	c.14803G>A/c.14825G>T	{"RYR1": {"c.14803G>A": 1, "c.14825G>T": 1}}	\N
7823691	7815081	c.7043A>G/c.11723A>T	{"RYR1": {"c.7043A>G": 1, "c.11723A>T": 1}}	\N
7823692	7815081	c.2122G>A/c.14539G>C	{"RYR1": {"c.2122G>A": 1, "c.14539G>C": 1}}	\N
7823693	7815081	c.1565A>C/c.14458G>A	{"RYR1": {"c.1565A>C": 1, "c.14458G>A": 1}}	\N
7823694	7815081	c.625G>A/c.7291G>A	{"RYR1": {"c.625G>A": 1, "c.7291G>A": 1}}	\N
7823695	7815081	c.12149C>A/c.13918A>G	{"RYR1": {"c.12149C>A": 1, "c.13918A>G": 1}}	\N
7823696	7815081	c.7048G>A/c.11958C>G	{"RYR1": {"c.7048G>A": 1, "c.11958C>G": 1}}	\N
7823697	7815081	c.1201C>G/c.7076G>A	{"RYR1": {"c.1201C>G": 1, "c.7076G>A": 1}}	\N
7823698	7815081	c.7099G>A/c.7879G>C	{"RYR1": {"c.7099G>A": 1, "c.7879G>C": 1}}	\N
7823699	7815081	c.7123G>A/c.13672C>T	{"RYR1": {"c.7123G>A": 1, "c.13672C>T": 1}}	\N
7823700	7815081	c.625G>A/c.7291G>T	{"RYR1": {"c.625G>A": 1, "c.7291G>T": 1}}	\N
7823701	7815081	c.7355G>C/c.11969G>T	{"RYR1": {"c.7355G>C": 1, "c.11969G>T": 1}}	\N
7823702	7815081	c.1597C>T/c.10891G>T	{"RYR1": {"c.1597C>T": 1, "c.10891G>T": 1}}	\N
7823703	7815081	c.7060G>A/c.7099G>A	{"RYR1": {"c.7060G>A": 1, "c.7099G>A": 1}}	\N
7823704	7815081	c.3667G>A/c.7291G>A	{"RYR1": {"c.3667G>A": 1, "c.7291G>A": 1}}	\N
7823705	7815081	c.992_994dup/c.7879G>C	{"RYR1": {"c.7879G>C": 1, "c.992_994dup": 1}}	\N
7823706	7815081	c.14126C>T/c.14512C>G	{"RYR1": {"c.14126C>T": 1, "c.14512C>G": 1}}	\N
7823707	7815081	c.463C>A/c.14782A>G	{"RYR1": {"c.463C>A": 1, "c.14782A>G": 1}}	\N
7823708	7815081	c.1021G>A/c.14524G>A	{"RYR1": {"c.1021G>A": 1, "c.14524G>A": 1}}	\N
7823709	7815081	c.7522C>T/c.8654C>G	{"RYR1": {"c.7522C>T": 1, "c.8654C>G": 1}}	\N
7823710	7815081	c.1202G>A/c.8290G>A	{"RYR1": {"c.1202G>A": 1, "c.8290G>A": 1}}	\N
7823711	7815081	c.6488G>T/c.7522C>G	{"RYR1": {"c.6488G>T": 1, "c.7522C>G": 1}}	\N
7823712	7815081	c.7760A>G/c.11315G>A	{"RYR1": {"c.7760A>G": 1, "c.11315G>A": 1}}	\N
7823713	7815081	c.6487C>T/c.7307G>A	{"RYR1": {"c.6487C>T": 1, "c.7307G>A": 1}}	\N
7823714	7815081	c.1834G>C/c.7310C>T	{"RYR1": {"c.1834G>C": 1, "c.7310C>T": 1}}	\N
7823715	7815081	c.7291G>T/c.14582G>A	{"RYR1": {"c.7291G>T": 1, "c.14582G>A": 1}}	\N
7823716	7815081	c.3166G>A/c.7354C>T	{"RYR1": {"c.3166G>A": 1, "c.7354C>T": 1}}	\N
7823717	7815081	c.3166G>C/c.6478G>A	{"RYR1": {"c.3166G>C": 1, "c.6478G>A": 1}}	\N
7823718	7815081	c.6488G>A/c.10237A>T	{"RYR1": {"c.6488G>A": 1, "c.10237A>T": 1}}	\N
7823719	7815081	c.7300G>A/c.8600T>A	{"RYR1": {"c.7300G>A": 1, "c.8600T>A": 1}}	\N
7823720	7815081	c.97A>G/c.496G>A	{"RYR1": {"c.97A>G": 1, "c.496G>A": 1}}	\N
7823721	7815081	c.7035C>A/c.7787C>T	{"RYR1": {"c.7035C>A": 1, "c.7787C>T": 1}}	\N
7823722	7815081	c.1459C>G/c.1841G>T	{"RYR1": {"c.1459C>G": 1, "c.1841G>T": 1}}	\N
7823723	7815081	c.1615T>G/c.13913G>A	{"RYR1": {"c.1615T>G": 1, "c.13913G>A": 1}}	\N
7823724	7815081	c.2050G>C/c.7042_7044delGAG	{"RYR1": {"c.2050G>C": 1, "c.7042_7044delGAG": 1}}	\N
7823725	7815081	c.8654C>G/c.9310G>A	{"RYR1": {"c.8654C>G": 1, "c.9310G>A": 1}}	\N
7823726	7815081	c.97A>G/c.5441T>A	{"RYR1": {"c.97A>G": 1, "c.5441T>A": 1}}	\N
7823727	7815081	c.6488G>T/c.7787C>T	{"RYR1": {"c.6488G>T": 1, "c.7787C>T": 1}}	\N
7823728	7815081	c.7090T>G/c.15059G>C	{"RYR1": {"c.7090T>G": 1, "c.15059G>C": 1}}	\N
7823729	7815081	c.7291G>T/c.13994_13995delTCinsCT	{"RYR1": {"c.7291G>T": 1, "c.13994_13995delTCinsCT": 1}}	\N
7823730	7815081	c.1021G>C/c.14879T>A	{"RYR1": {"c.1021G>C": 1, "c.14879T>A": 1}}	\N
7823731	7815081	c.9848G>A/c.14209C>T	{"RYR1": {"c.9848G>A": 1, "c.14209C>T": 1}}	\N
7823732	7815081	c.496G>A/c.7063C>T	{"RYR1": {"c.496G>A": 1, "c.7063C>T": 1}}	\N
7823733	7815081	c.1459C>G/c.5183C>T	{"RYR1": {"c.1459C>G": 1, "c.5183C>T": 1}}	\N
7823734	7815081	c.3656A>C/c.14512C>G	{"RYR1": {"c.3656A>C": 1, "c.14512C>G": 1}}	\N
7823735	7815081	c.7354C>T/c.13994_13995delTCinsCT	{"RYR1": {"c.7354C>T": 1, "c.13994_13995delTCinsCT": 1}}	\N
7823736	7815081	c.5441T>A/c.9310G>A	{"RYR1": {"c.5441T>A": 1, "c.9310G>A": 1}}	\N
7823737	7815081	c.6488G>A/c.6548G>A	{"RYR1": {"c.6488G>A": 1, "c.6548G>A": 1}}	\N
7823738	7815081	c.6617C>G/c.13934G>A	{"RYR1": {"c.6617C>G": 1, "c.13934G>A": 1}}	\N
7823739	7815081	c.6478G>A/c.7043A>G	{"RYR1": {"c.6478G>A": 1, "c.7043A>G": 1}}	\N
7823740	7815081	c.7522C>T/c.7778G>A	{"RYR1": {"c.7522C>T": 1, "c.7778G>A": 1}}	\N
7823741	7815081	c.7007G>A/c.13994_13995delTCinsCT	{"RYR1": {"c.7007G>A": 1, "c.13994_13995delTCinsCT": 1}}	\N
7823742	7815081	c.6838G>A/c.12355A>T	{"RYR1": {"c.6838G>A": 1, "c.12355A>T": 1}}	\N
7823743	7815081	c.1201C>T/c.14581C>T	{"RYR1": {"c.1201C>T": 1, "c.14581C>T": 1}}	\N
7823744	7815081	c.529C>T/c.11958C>G	{"RYR1": {"c.529C>T": 1, "c.11958C>G": 1}}	\N
7823745	7815081	c.7042_7044delGAG/c.14002C>T	{"RYR1": {"c.14002C>T": 1, "c.7042_7044delGAG": 1}}	\N
7823746	7815081	c.982C>T/c.1553T>C	{"RYR1": {"c.982C>T": 1, "c.1553T>C": 1}}	\N
7823747	7815081	c.14582G>A/c.14627A>G	{"RYR1": {"c.14582G>A": 1, "c.14627A>G": 1}}	\N
7823748	7815081	c.1840C>T/c.11813G>A	{"RYR1": {"c.1840C>T": 1, "c.11813G>A": 1}}	\N
7823749	7815081	c.1615T>C/c.6599C>T	{"RYR1": {"c.1615T>C": 1, "c.6599C>T": 1}}	\N
7823750	7815081	c.11315G>A/c.14471T>C	{"RYR1": {"c.11315G>A": 1, "c.14471T>C": 1}}	\N
7823751	7815081	c.7007G>A/c.14582G>A	{"RYR1": {"c.7007G>A": 1, "c.14582G>A": 1}}	\N
7823752	7815081	c.7879G>A/c.14210G>A	{"RYR1": {"c.7879G>A": 1, "c.14210G>A": 1}}	\N
7823753	7815081	c.7304G>A/c.9652G>A	{"RYR1": {"c.7304G>A": 1, "c.9652G>A": 1}}	\N
7823754	7815081	c.7373G>T/c.8638G>A	{"RYR1": {"c.7373G>T": 1, "c.8638G>A": 1}}	\N
7823755	7815081	c.9652G>A/c.14918C>T	{"RYR1": {"c.9652G>A": 1, "c.14918C>T": 1}}	\N
7823756	7815081	c.11813G>A/c.14803G>A	{"RYR1": {"c.11813G>A": 1, "c.14803G>A": 1}}	\N
7823757	7815081	c.1565A>C/c.8926C>T	{"RYR1": {"c.1565A>C": 1, "c.8926C>T": 1}}	\N
7823758	7815081	c.1209C>G/c.7043A>G	{"RYR1": {"c.1209C>G": 1, "c.7043A>G": 1}}	\N
7823759	7815081	c.6302T>A/c.14209C>T	{"RYR1": {"c.6302T>A": 1, "c.14209C>T": 1}}	\N
7823760	7815081	c.6838G>A/c.7210G>A	{"RYR1": {"c.6838G>A": 1, "c.7210G>A": 1}}	\N
7823761	7815081	c.1565A>G/c.15059G>C	{"RYR1": {"c.1565A>G": 1, "c.15059G>C": 1}}	\N
7823762	7815081	c.6838G>A/c.13918A>G	{"RYR1": {"c.6838G>A": 1, "c.13918A>G": 1}}	\N
7823763	7815081	c.9850T>A/c.14512C>G	{"RYR1": {"c.9850T>A": 1, "c.14512C>G": 1}}	\N
7823764	7815081	c.1841G>T/c.14818G>A	{"RYR1": {"c.1841G>T": 1, "c.14818G>A": 1}}	\N
7823765	7815081	c.487C>T/c.1024G>A	{"RYR1": {"c.487C>T": 1, "c.1024G>A": 1}}	\N
7823766	7815081	c.488G>T/c.13760C>T	{"RYR1": {"c.488G>T": 1, "c.13760C>T": 1}}	\N
7823767	7815081	c.7304G>A/c.9676G>C	{"RYR1": {"c.7304G>A": 1, "c.9676G>C": 1}}	\N
7823768	7815081	c.982C>T/c.14186A>C	{"RYR1": {"c.982C>T": 1, "c.14186A>C": 1}}	\N
7823769	7815081	c.6487C>T/c.9848G>A	{"RYR1": {"c.6487C>T": 1, "c.9848G>A": 1}}	\N
7823770	7815081	c.38T>G/c.497A>G	{"RYR1": {"c.38T>G": 1, "c.497A>G": 1}}	\N
7823771	7815081	c.6742C>T/c.8026C>T	{"RYR1": {"c.6742C>T": 1, "c.8026C>T": 1}}	\N
7823772	7815081	c.982C>T/c.12413T>C	{"RYR1": {"c.982C>T": 1, "c.12413T>C": 1}}	\N
7823773	7815081	c.51_53del/c.6838G>A	{"RYR1": {"c.6838G>A": 1, "c.51_53del": 1}}	\N
7823774	7815081	c.7310C>T/c.14126C>T	{"RYR1": {"c.7310C>T": 1, "c.14126C>T": 1}}	\N
7823775	7815081	c.1597C>T/c.14680G>A	{"RYR1": {"c.1597C>T": 1, "c.14680G>A": 1}}	\N
7823776	7815081	c.1565A>G/c.15060G>C	{"RYR1": {"c.1565A>G": 1, "c.15060G>C": 1}}	\N
7823777	7815081	c.992_994dup/c.6349G>C	{"RYR1": {"c.6349G>C": 1, "c.992_994dup": 1}}	\N
7823778	7815081	c.7291G>T/c.12028G>A	{"RYR1": {"c.7291G>T": 1, "c.12028G>A": 1}}	\N
7823779	7815081	c.7372C>T/c.14582G>A	{"RYR1": {"c.7372C>T": 1, "c.14582G>A": 1}}	\N
7823780	7815081	c.6488G>T/c.6671G>A	{"RYR1": {"c.6488G>T": 1, "c.6671G>A": 1}}	\N
7823781	7815081	c.7361G>A/c.13760C>T	{"RYR1": {"c.7361G>A": 1, "c.13760C>T": 1}}	\N
7823782	7815081	c.3418C>T/c.7063C>T	{"RYR1": {"c.3418C>T": 1, "c.7063C>T": 1}}	\N
7823783	7815081	c.1565A>C/c.6388G>A	{"RYR1": {"c.1565A>C": 1, "c.6388G>A": 1}}	\N
7823784	7815081	c.488G>T/c.14364+1G>T	{"RYR1": {"c.488G>T": 1, "c.14364+1G>T": 1}}	\N
7823785	7815081	c.6502G>A/c.12689T>G	{"RYR1": {"c.6502G>A": 1, "c.12689T>G": 1}}	\N
7823786	7815081	c.1597C>T/c.12848A>T	{"RYR1": {"c.1597C>T": 1, "c.12848A>T": 1}}	\N
7823787	7815081	c.6743G>A/c.14627A>G	{"RYR1": {"c.6743G>A": 1, "c.14627A>G": 1}}	\N
7823788	7815081	c.528G>T/c.7043A>G	{"RYR1": {"c.528G>T": 1, "c.7043A>G": 1}}	\N
7823789	7815081	c.13918A>G/c.14918C>T	{"RYR1": {"c.13918A>G": 1, "c.14918C>T": 1}}	\N
7823790	7815081	c.7879G>C/c.14879T>A	{"RYR1": {"c.7879G>C": 1, "c.14879T>A": 1}}	\N
7823791	7815081	c.6488G>A/c.12848A>T	{"RYR1": {"c.6488G>A": 1, "c.12848A>T": 1}}	\N
7823792	7815081	c.6640G>A/c.11315G>A	{"RYR1": {"c.6640G>A": 1, "c.11315G>A": 1}}	\N
7823793	7815081	c.7063C>T/c.13505A>G	{"RYR1": {"c.7063C>T": 1, "c.13505A>G": 1}}	\N
7823794	7815081	c.130C>T/c.9499C>T	{"RYR1": {"c.130C>T": 1, "c.9499C>T": 1}}	\N
7823795	7815081	c.7123G>A/c.14814C>G	{"RYR1": {"c.7123G>A": 1, "c.14814C>G": 1}}	\N
7823796	7815081	c.190T>C/c.8026C>T	{"RYR1": {"c.190T>C": 1, "c.8026C>T": 1}}	\N
7823797	7815081	c.1459C>G/c.7291G>T	{"RYR1": {"c.1459C>G": 1, "c.7291G>T": 1}}	\N
7823798	7815081	c.13760C>T/c.14210G>A	{"RYR1": {"c.13760C>T": 1, "c.14210G>A": 1}}	\N
7823799	7815081	c.178G>A/c.14512C>G	{"RYR1": {"c.178G>A": 1, "c.14512C>G": 1}}	\N
7823800	7815081	c.533A>G/c.2924G>A	{"RYR1": {"c.533A>G": 1, "c.2924G>A": 1}}	\N
7823801	7815081	c.533A>C/c.7035C>A	{"RYR1": {"c.533A>C": 1, "c.7035C>A": 1}}	\N
7823802	7815081	c.6617C>T/c.12355A>T	{"RYR1": {"c.6617C>T": 1, "c.12355A>T": 1}}	\N
7823803	7815081	c.8026C>T/c.14197T>G	{"RYR1": {"c.8026C>T": 1, "c.14197T>G": 1}}	\N
7823804	7815081	c.178G>T/c.14477C>T	{"RYR1": {"c.178G>T": 1, "c.14477C>T": 1}}	\N
7823805	7815081	c.7372C>T/c.14387A>G	{"RYR1": {"c.7372C>T": 1, "c.14387A>G": 1}}	\N
7823806	7815081	c.7076G>A/c.12121C>T	{"RYR1": {"c.7076G>A": 1, "c.12121C>T": 1}}	\N
7823807	7815081	c.11315G>A/c.13673G>A	{"RYR1": {"c.11315G>A": 1, "c.13673G>A": 1}}	\N
7823808	7815081	c.1201C>A/c.7076G>A	{"RYR1": {"c.1201C>A": 1, "c.7076G>A": 1}}	\N
7823809	7815081	c.251C>T/c.7304G>A	{"RYR1": {"c.251C>T": 1, "c.7304G>A": 1}}	\N
7823810	7815081	c.10042C>T/c.11315G>A	{"RYR1": {"c.10042C>T": 1, "c.11315G>A": 1}}	\N
7823811	7815081	c.1459C>G/c.7291G>A	{"RYR1": {"c.1459C>G": 1, "c.7291G>A": 1}}	\N
7823812	7815081	c.7063C>T/c.7097C>G	{"RYR1": {"c.7063C>T": 1, "c.7097C>G": 1}}	\N
7823813	7815081	c.11708G>A/c.13505A>G	{"RYR1": {"c.11708G>A": 1, "c.13505A>G": 1}}	\N
7823814	7815081	c.1597C>A/c.14918C>T	{"RYR1": {"c.1597C>A": 1, "c.14918C>T": 1}}	\N
7823815	7815081	c.7035C>A/c.13702C>G	{"RYR1": {"c.7035C>A": 1, "c.13702C>G": 1}}	\N
7823816	7815081	c.251C>T/c.7304G>T	{"RYR1": {"c.251C>T": 1, "c.7304G>T": 1}}	\N
7823817	7815081	c.3527C>T/c.7043A>G	{"RYR1": {"c.3527C>T": 1, "c.7043A>G": 1}}	\N
7823818	7815081	c.1475G>A/c.7282G>A	{"RYR1": {"c.1475G>A": 1, "c.7282G>A": 1}}	\N
7823819	7815081	c.2996G>A/c.6838G>A	{"RYR1": {"c.2996G>A": 1, "c.6838G>A": 1}}	\N
7823820	7815081	c.7771C>G/c.14209C>T	{"RYR1": {"c.7771C>G": 1, "c.14209C>T": 1}}	\N
7823821	7815081	c.7522C>T/c.12355A>T	{"RYR1": {"c.7522C>T": 1, "c.12355A>T": 1}}	\N
7823822	7815081	c.6488G>C/c.12848A>T	{"RYR1": {"c.6488G>C": 1, "c.12848A>T": 1}}	\N
7823823	7815081	c.7199A>G/c.14497C>T	{"RYR1": {"c.7199A>G": 1, "c.14497C>T": 1}}	\N
7823824	7815081	c.1021G>C/c.6478G>A	{"RYR1": {"c.1021G>C": 1, "c.6478G>A": 1}}	\N
7823825	7815081	c.7522C>T/c.14825G>T	{"RYR1": {"c.7522C>T": 1, "c.14825G>T": 1}}	\N
7823826	7815081	c.488G>T/c.8926C>T	{"RYR1": {"c.488G>T": 1, "c.8926C>T": 1}}	\N
7823827	7815081	c.7063C>T/c.11813G>A	{"RYR1": {"c.7063C>T": 1, "c.11813G>A": 1}}	\N
7823828	7815081	c.7361G>A/c.12398A>G	{"RYR1": {"c.7361G>A": 1, "c.12398A>G": 1}}	\N
7823829	7815081	c.6838G>A/c.6847A>C	{"RYR1": {"c.6838G>A": 1, "c.6847A>C": 1}}	\N
7823830	7815081	c.11708G>A/c.14782A>G	{"RYR1": {"c.11708G>A": 1, "c.14782A>G": 1}}	\N
7823831	7815081	c.130C>T/c.1598G>A	{"RYR1": {"c.130C>T": 1, "c.1598G>A": 1}}	\N
7823832	7815081	c.982C>T/c.5033A>G	{"RYR1": {"c.982C>T": 1, "c.5033A>G": 1}}	\N
7823833	7815081	c.1202G>T/c.14693T>C	{"RYR1": {"c.1202G>T": 1, "c.14693T>C": 1}}	\N
7823834	7815081	c.7124G>C/c.14197T>G	{"RYR1": {"c.7124G>C": 1, "c.14197T>G": 1}}	\N
7823835	7815081	c.6502G>A/c.9268G>A	{"RYR1": {"c.6502G>A": 1, "c.9268G>A": 1}}	\N
7823836	7815081	c.7035C>A/c.14270G>A	{"RYR1": {"c.7035C>A": 1, "c.14270G>A": 1}}	\N
7823837	7815081	c.130C>T/c.11518G>A	{"RYR1": {"c.130C>T": 1, "c.11518G>A": 1}}	\N
7823838	7815081	c.479A>G/c.7035C>A	{"RYR1": {"c.479A>G": 1, "c.7035C>A": 1}}	\N
7823839	7815081	c.6617C>G/c.11748T>G	{"RYR1": {"c.6617C>G": 1, "c.11748T>G": 1}}	\N
7823840	7815081	c.463C>A/c.2537C>T	{"RYR1": {"c.463C>A": 1, "c.2537C>T": 1}}	\N
7823841	7815081	c.7073T>A/c.7304G>T	{"RYR1": {"c.7073T>A": 1, "c.7304G>T": 1}}	\N
7823842	7815081	c.7355G>A/c.9310G>A	{"RYR1": {"c.7355G>A": 1, "c.9310G>A": 1}}	\N
7823843	7815081	c.7304G>T/c.14387A>G	{"RYR1": {"c.7304G>T": 1, "c.14387A>G": 1}}	\N
7823844	7815081	c.7354C>T/c.12028G>A	{"RYR1": {"c.7354C>T": 1, "c.12028G>A": 1}}	\N
7823845	7815081	c.130C>T/c.9152G>A	{"RYR1": {"c.130C>T": 1, "c.9152G>A": 1}}	\N
7823846	7815081	c.7310C>T/c.12383C>T	{"RYR1": {"c.7310C>T": 1, "c.12383C>T": 1}}	\N
7823847	7815081	c.6488G>A/c.14270G>A	{"RYR1": {"c.6488G>A": 1, "c.14270G>A": 1}}	\N
7823848	7815081	c.680A>T/c.14539G>C	{"RYR1": {"c.680A>T": 1, "c.14539G>C": 1}}	\N
7823849	7815081	c.1021G>A/c.6478G>A	{"RYR1": {"c.1021G>A": 1, "c.6478G>A": 1}}	\N
7823850	7815081	c.3667G>A/c.6628G>T	{"RYR1": {"c.3667G>A": 1, "c.6628G>T": 1}}	\N
7823851	7815081	c.1565A>G/c.6388G>A	{"RYR1": {"c.1565A>G": 1, "c.6388G>A": 1}}	\N
7823852	7815081	c.7073T>A/c.7304G>A	{"RYR1": {"c.7073T>A": 1, "c.7304G>A": 1}}	\N
7823853	7815081	c.1630G>T/c.14424C>A	{"RYR1": {"c.1630G>T": 1, "c.14424C>A": 1}}	\N
7823854	7815081	c.7373G>A/c.15059G>C	{"RYR1": {"c.7373G>A": 1, "c.15059G>C": 1}}	\N
7823855	7815081	c.3166G>C/c.14524G>A	{"RYR1": {"c.3166G>C": 1, "c.14524G>A": 1}}	\N
7823856	7815081	c.7123G>A/c.14201G>A	{"RYR1": {"c.7123G>A": 1, "c.14201G>A": 1}}	\N
7823857	7815081	c.12700G>T/c.14814C>G	{"RYR1": {"c.12700G>T": 1, "c.14814C>G": 1}}	\N
7823858	7815081	c.119G>C/c.7007G>A	{"RYR1": {"c.119G>C": 1, "c.7007G>A": 1}}	\N
7823859	7815081	c.10252A>G/c.14210G>A	{"RYR1": {"c.10252A>G": 1, "c.14210G>A": 1}}	\N
7823860	7815081	c.212C>A/c.14209C>T	{"RYR1": {"c.212C>A": 1, "c.14209C>T": 1}}	\N
7823861	7815081	c.7090T>G/c.14458G>T	{"RYR1": {"c.7090T>G": 1, "c.14458G>T": 1}}	\N
7823862	7815081	c.12700G>T/c.14201G>A	{"RYR1": {"c.12700G>T": 1, "c.14201G>A": 1}}	\N
7823863	7815081	c.6743G>A/c.12149C>A	{"RYR1": {"c.6743G>A": 1, "c.12149C>A": 1}}	\N
7823864	7815081	c.6544A>T/c.14627A>G	{"RYR1": {"c.6544A>T": 1, "c.14627A>G": 1}}	\N
7823865	7815081	c.152C>A/c.1630G>T	{"RYR1": {"c.152C>A": 1, "c.1630G>T": 1}}	\N
7823866	7815081	c.6387C>G/c.11132C>T	{"RYR1": {"c.6387C>G": 1, "c.11132C>T": 1}}	\N
7823867	7815081	c.6387C>G/c.8188G>C	{"RYR1": {"c.6387C>G": 1, "c.8188G>C": 1}}	\N
7823868	7815081	c.12115A>T/c.14803G>A	{"RYR1": {"c.12115A>T": 1, "c.14803G>A": 1}}	\N
7823869	7815081	c.1654C>T/c.3667G>A	{"RYR1": {"c.1654C>T": 1, "c.3667G>A": 1}}	\N
7823870	7815081	c.7090T>G/c.14458G>A	{"RYR1": {"c.7090T>G": 1, "c.14458G>A": 1}}	\N
7823871	7815081	c.1411C>T/c.14477C>T	{"RYR1": {"c.1411C>T": 1, "c.14477C>T": 1}}	\N
7823872	7815081	c.3656A>C/c.14803G>A	{"RYR1": {"c.3656A>C": 1, "c.14803G>A": 1}}	\N
7823873	7815081	c.7487C>T/c.14803G>A	{"RYR1": {"c.7487C>T": 1, "c.14803G>A": 1}}	\N
7823874	7815081	c.7112A>G/c.14918C>T	{"RYR1": {"c.7112A>G": 1, "c.14918C>T": 1}}	\N
7823875	7815081	c.463C>A/c.14817C>A	{"RYR1": {"c.463C>A": 1, "c.14817C>A": 1}}	\N
7823876	7815081	c.7035C>A/c.14581C>T	{"RYR1": {"c.7035C>A": 1, "c.14581C>T": 1}}	\N
7823877	7815081	c.7035C>A/c.7317G>C	{"RYR1": {"c.7035C>A": 1, "c.7317G>C": 1}}	\N
7823878	7815081	c.7076G>A/c.14782A>G	{"RYR1": {"c.7076G>A": 1, "c.14782A>G": 1}}	\N
7823879	7815081	c.487C>T/c.14567C>G	{"RYR1": {"c.487C>T": 1, "c.14567C>G": 1}}	\N
7823880	7815081	c.1201C>T/c.1422G>T	{"RYR1": {"c.1201C>T": 1, "c.1422G>T": 1}}	\N
7823881	7815081	c.11120G>T/c.14477C>T	{"RYR1": {"c.11120G>T": 1, "c.14477C>T": 1}}	\N
7823882	7815081	c.6488G>C/c.14270G>A	{"RYR1": {"c.6488G>C": 1, "c.14270G>A": 1}}	\N
7823883	7815081	c.1654C>T/c.11723A>T	{"RYR1": {"c.1654C>T": 1, "c.11723A>T": 1}}	\N
7823884	7815081	c.10891G>T/c.14539G>C	{"RYR1": {"c.10891G>T": 1, "c.14539G>C": 1}}	\N
7823885	7815081	c.7373G>T/c.14782A>G	{"RYR1": {"c.7373G>T": 1, "c.14782A>G": 1}}	\N
7823886	7815081	c.14126C>T/c.14803G>A	{"RYR1": {"c.14126C>T": 1, "c.14803G>A": 1}}	\N
7823887	7815081	c.5183C>T/c.8638G>A	{"RYR1": {"c.5183C>T": 1, "c.8638G>A": 1}}	\N
7823888	7815081	c.455C>A/c.14512C>G	{"RYR1": {"c.455C>A": 1, "c.14512C>G": 1}}	\N
7823889	7815081	c.463C>A/c.8638G>A	{"RYR1": {"c.463C>A": 1, "c.8638G>A": 1}}	\N
7823890	7815081	c.463C>A/c.641C>T	{"RYR1": {"c.463C>A": 1, "c.641C>T": 1}}	\N
7823891	7815081	c.7073T>A/c.7123G>A	{"RYR1": {"c.7073T>A": 1, "c.7123G>A": 1}}	\N
7823892	7815081	c.1201C>T/c.13994_13995delTCinsCT	{"RYR1": {"c.1201C>T": 1, "c.13994_13995delTCinsCT": 1}}	\N
7823893	7815081	c.178G>A/c.7007G>A	{"RYR1": {"c.178G>A": 1, "c.7007G>A": 1}}	\N
7823894	7815081	c.742G>A/c.13913G>A	{"RYR1": {"c.742G>A": 1, "c.13913G>A": 1}}	\N
7823895	7815081	c.6488G>C/c.10891G>T	{"RYR1": {"c.6488G>C": 1, "c.10891G>T": 1}}	\N
7823896	7815081	c.14545G>A/c.15060G>C	{"RYR1": {"c.14545G>A": 1, "c.15060G>C": 1}}	\N
7823897	7815081	c.7032G>C/c.7523G>A	{"RYR1": {"c.7032G>C": 1, "c.7523G>A": 1}}	\N
7823898	7815081	c.2996G>A/c.7522C>T	{"RYR1": {"c.2996G>A": 1, "c.7522C>T": 1}}	\N
7823899	7815081	c.6847A>C/c.14210G>A	{"RYR1": {"c.6847A>C": 1, "c.14210G>A": 1}}	\N
7823900	7815081	c.5890C>T/c.7523G>A	{"RYR1": {"c.5890C>T": 1, "c.7523G>A": 1}}	\N
7823901	7815081	c.3166G>C/c.14422_14423delinsAA	{"RYR1": {"c.3166G>C": 1, "c.14422_14423delinsAA": 1}}	\N
7823902	7815081	c.1024G>A/c.11969G>T	{"RYR1": {"c.1024G>A": 1, "c.11969G>T": 1}}	\N
7823903	7815081	c.6640G>A/c.14539G>C	{"RYR1": {"c.6640G>A": 1, "c.14539G>C": 1}}	\N
7823904	7815081	c.4763C>T/c.6612C>G	{"RYR1": {"c.4763C>T": 1, "c.6612C>G": 1}}	\N
7823905	7815081	c.1201C>T/c.3095G>A	{"RYR1": {"c.1201C>T": 1, "c.3095G>A": 1}}	\N
7823906	7815081	c.5341T>C/c.7035C>A	{"RYR1": {"c.5341T>C": 1, "c.7035C>A": 1}}	\N
7823907	7815081	c.7291G>T/c.11958C>G	{"RYR1": {"c.7291G>T": 1, "c.11958C>G": 1}}	\N
7823908	7815081	c.6628G>T/c.8189A>G	{"RYR1": {"c.6628G>T": 1, "c.8189A>G": 1}}	\N
7823909	7815081	c.6635T>A/c.7360C>T	{"RYR1": {"c.6635T>A": 1, "c.7360C>T": 1}}	\N
7823910	7815081	c.12700G>C/c.13672C>T	{"RYR1": {"c.12700G>C": 1, "c.13672C>T": 1}}	\N
7823911	7815081	c.463C>A/c.3656A>C	{"RYR1": {"c.463C>A": 1, "c.3656A>C": 1}}	\N
7823912	7815081	c.1597C>A/c.6488G>C	{"RYR1": {"c.1597C>A": 1, "c.6488G>C": 1}}	\N
7823913	7815081	c.7373G>A/c.15060G>C	{"RYR1": {"c.7373G>A": 1, "c.15060G>C": 1}}	\N
7823914	7815081	c.7035C>A/c.9850T>A	{"RYR1": {"c.7035C>A": 1, "c.9850T>A": 1}}	\N
7823915	7815081	c.1597C>A/c.6488G>A	{"RYR1": {"c.1597C>A": 1, "c.6488G>A": 1}}	\N
7823916	7815081	c.103T>C/c.5341T>C	{"RYR1": {"c.103T>C": 1, "c.5341T>C": 1}}	\N
7823917	7815081	c.1021G>C/c.5890C>T	{"RYR1": {"c.1021G>C": 1, "c.5890C>T": 1}}	\N
7823918	7815081	c.6488G>C/c.7317G>C	{"RYR1": {"c.6488G>C": 1, "c.7317G>C": 1}}	\N
7823919	7815081	c.130C>T/c.5186T>G	{"RYR1": {"c.130C>T": 1, "c.5186T>G": 1}}	\N
7823920	7815081	c.51_53del/c.7522C>T	{"RYR1": {"c.7522C>T": 1, "c.51_53del": 1}}	\N
7823921	7815081	c.1597C>A/c.6488G>T	{"RYR1": {"c.1597C>A": 1, "c.6488G>T": 1}}	\N
7823922	7815081	c.12700G>C/c.14814C>G	{"RYR1": {"c.12700G>C": 1, "c.14814C>G": 1}}	\N
7823923	7815081	c.1630G>T/c.14002C>T	{"RYR1": {"c.1630G>T": 1, "c.14002C>T": 1}}	\N
7823924	7815081	c.1841G>T/c.12121C>T	{"RYR1": {"c.1841G>T": 1, "c.12121C>T": 1}}	\N
7823925	7815081	c.7048G>A/c.13994_13995delTCinsCT	{"RYR1": {"c.7048G>A": 1, "c.13994_13995delTCinsCT": 1}}	\N
7823926	7815081	c.6617C>G/c.7317G>C	{"RYR1": {"c.6617C>G": 1, "c.7317G>C": 1}}	\N
7823927	7815081	c.6377G>A/c.14209C>T	{"RYR1": {"c.6377G>A": 1, "c.14209C>T": 1}}	\N
7823928	7815081	c.3418C>T/c.7358T>C	{"RYR1": {"c.3418C>T": 1, "c.7358T>C": 1}}	\N
7823929	7815081	c.742G>C/c.13913G>A	{"RYR1": {"c.742G>C": 1, "c.13913G>A": 1}}	\N
7823930	7815081	c.3172G>A/c.8026C>T	{"RYR1": {"c.3172G>A": 1, "c.8026C>T": 1}}	\N
7823931	7815081	c.7760A>G/c.14539G>C	{"RYR1": {"c.7760A>G": 1, "c.14539G>C": 1}}	\N
7823932	7815081	c.677T>A/c.14512C>G	{"RYR1": {"c.677T>A": 1, "c.14512C>G": 1}}	\N
7823933	7815081	c.7084G>A/c.14581C>T	{"RYR1": {"c.7084G>A": 1, "c.14581C>T": 1}}	\N
7823934	7815081	c.6488G>A/c.10891G>T	{"RYR1": {"c.6488G>A": 1, "c.10891G>T": 1}}	\N
7823935	7815081	c.7282G>A/c.9499C>T	{"RYR1": {"c.7282G>A": 1, "c.9499C>T": 1}}	\N
7823936	7815081	c.1553T>C/c.7123G>A	{"RYR1": {"c.1553T>C": 1, "c.7123G>A": 1}}	\N
7823937	7815081	c.97A>G/c.5132A>G	{"RYR1": {"c.97A>G": 1, "c.5132A>G": 1}}	\N
7823938	7815081	c.2537C>T/c.7304G>A	{"RYR1": {"c.2537C>T": 1, "c.7304G>A": 1}}	\N
7823939	7815081	c.1100G>A/c.14539G>C	{"RYR1": {"c.1100G>A": 1, "c.14539G>C": 1}}	\N
7823940	7815081	c.493G>A/c.1597C>T	{"RYR1": {"c.493G>A": 1, "c.1597C>T": 1}}	\N
7823941	7815081	c.6640G>A/c.7361G>A	{"RYR1": {"c.6640G>A": 1, "c.7361G>A": 1}}	\N
7823942	7815081	c.6617C>G/c.7522C>G	{"RYR1": {"c.6617C>G": 1, "c.7522C>G": 1}}	\N
7823943	7815081	c.7123G>A/c.9649T>C	{"RYR1": {"c.7123G>A": 1, "c.9649T>C": 1}}	\N
7823944	7815081	c.742G>A/c.9758T>C	{"RYR1": {"c.742G>A": 1, "c.9758T>C": 1}}	\N
7823945	7815081	c.4763C>T/c.7043A>G	{"RYR1": {"c.4763C>T": 1, "c.7043A>G": 1}}	\N
7823946	7815081	c.533A>G/c.14818G>A	{"RYR1": {"c.533A>G": 1, "c.14818G>A": 1}}	\N
7823947	7815081	c.1201C>T/c.7075C>T	{"RYR1": {"c.1201C>T": 1, "c.7075C>T": 1}}	\N
7823948	7815081	c.12149C>A/c.14002C>T	{"RYR1": {"c.12149C>A": 1, "c.14002C>T": 1}}	\N
7823949	7815081	c.7291G>A/c.9868G>A	{"RYR1": {"c.7291G>A": 1, "c.9868G>A": 1}}	\N
7823950	7815081	c.1202G>T/c.14813T>C	{"RYR1": {"c.1202G>T": 1, "c.14813T>C": 1}}	\N
7823951	7815081	c.1021G>A/c.5890C>T	{"RYR1": {"c.1021G>A": 1, "c.5890C>T": 1}}	\N
7823952	7815081	c.7361G>A/c.12533G>T	{"RYR1": {"c.7361G>A": 1, "c.12533G>T": 1}}	\N
7823953	7815081	c.6488G>A/c.7317G>C	{"RYR1": {"c.6488G>A": 1, "c.7317G>C": 1}}	\N
7823954	7815081	c.6487C>T/c.10252A>G	{"RYR1": {"c.6487C>T": 1, "c.10252A>G": 1}}	\N
7823955	7815081	c.6487C>T/c.7073T>A	{"RYR1": {"c.6487C>T": 1, "c.7073T>A": 1}}	\N
7823956	7815081	c.7300G>A/c.7307G>A	{"RYR1": {"c.7300G>A": 1, "c.7307G>A": 1}}	\N
7823957	7815081	c.7097C>G/c.7300G>A	{"RYR1": {"c.7097C>G": 1, "c.7300G>A": 1}}	\N
7823958	7815081	c.14545G>A/c.15059G>C	{"RYR1": {"c.14545G>A": 1, "c.15059G>C": 1}}	\N
7823959	7815081	c.5183C>T/c.9635A>G	{"RYR1": {"c.5183C>T": 1, "c.9635A>G": 1}}	\N
7823960	7815081	c.487C>T/c.7085A>G	{"RYR1": {"c.487C>T": 1, "c.7085A>G": 1}}	\N
7823961	7815081	c.6628G>T/c.11314C>T	{"RYR1": {"c.6628G>T": 1, "c.11314C>T": 1}}	\N
7823962	7815081	c.529C>T/c.13994_13995delTCinsCT	{"RYR1": {"c.529C>T": 1, "c.13994_13995delTCinsCT": 1}}	\N
7823963	7815081	c.982C>T/c.11120G>T	{"RYR1": {"c.982C>T": 1, "c.11120G>T": 1}}	\N
7823964	7815081	c.7090T>G/c.8926C>T	{"RYR1": {"c.7090T>G": 1, "c.8926C>T": 1}}	\N
7823965	7815081	c.1460T>C/c.6502G>A	{"RYR1": {"c.1460T>C": 1, "c.6502G>A": 1}}	\N
7823966	7815081	c.7373G>A/c.8638G>A	{"RYR1": {"c.7373G>A": 1, "c.8638G>A": 1}}	\N
7823967	7815081	c.3527C>T/c.6612C>G	{"RYR1": {"c.3527C>T": 1, "c.6612C>G": 1}}	\N
7823968	7815081	c.6488G>A/c.7787C>T	{"RYR1": {"c.6488G>A": 1, "c.7787C>T": 1}}	\N
7823969	7815081	c.1630G>T/c.3527C>T	{"RYR1": {"c.1630G>T": 1, "c.3527C>T": 1}}	\N
7823970	7815081	c.6838G>A/c.11953T>C	{"RYR1": {"c.6838G>A": 1, "c.11953T>C": 1}}	\N
7823971	7815081	c.6617C>G/c.14424C>A	{"RYR1": {"c.6617C>G": 1, "c.14424C>A": 1}}	\N
7823972	7815081	c.4400A>G/c.6502G>A	{"RYR1": {"c.4400A>G": 1, "c.6502G>A": 1}}	\N
7823973	7815081	c.526G>A/c.7282G>A	{"RYR1": {"c.526G>A": 1, "c.7282G>A": 1}}	\N
7823974	7815081	c.1630G>T/c.11953T>C	{"RYR1": {"c.1630G>T": 1, "c.11953T>C": 1}}	\N
7823975	7815081	c.51_53del/c.14497C>T	{"RYR1": {"c.14497C>T": 1, "c.51_53del": 1}}	\N
7823976	7815081	c.6487C>T/c.13990T>C	{"RYR1": {"c.6487C>T": 1, "c.13990T>C": 1}}	\N
7823977	7815081	c.7099G>A/c.7300G>A	{"RYR1": {"c.7099G>A": 1, "c.7300G>A": 1}}	\N
7823978	7815081	c.190T>C/c.14210G>A	{"RYR1": {"c.190T>C": 1, "c.14210G>A": 1}}	\N
7823979	7815081	c.6488G>T/c.10237A>T	{"RYR1": {"c.6488G>T": 1, "c.10237A>T": 1}}	\N
7823980	7815081	c.6488G>A/c.14680G>A	{"RYR1": {"c.6488G>A": 1, "c.14680G>A": 1}}	\N
7823981	7815081	c.131G>A/c.7042_7044delGAG	{"RYR1": {"c.131G>A": 1, "c.7042_7044delGAG": 1}}	\N
7823982	7815081	c.677T>A/c.14477C>T	{"RYR1": {"c.677T>A": 1, "c.14477C>T": 1}}	\N
7823983	7815081	c.742G>C/c.9758T>C	{"RYR1": {"c.742G>C": 1, "c.9758T>C": 1}}	\N
7823984	7815081	c.496G>A/c.982C>T	{"RYR1": {"c.496G>A": 1, "c.982C>T": 1}}	\N
7823985	7815081	c.7291G>A/c.13994_13995delTCinsCT	{"RYR1": {"c.7291G>A": 1, "c.13994_13995delTCinsCT": 1}}	\N
7823986	7815081	c.38T>G/c.8926C>T	{"RYR1": {"c.38T>G": 1, "c.8926C>T": 1}}	\N
7823987	7815081	c.6502G>A/c.14524G>A	{"RYR1": {"c.6502G>A": 1, "c.14524G>A": 1}}	\N
7823988	7815081	c.103T>C/c.14126C>T	{"RYR1": {"c.103T>C": 1, "c.14126C>T": 1}}	\N
7823989	7815081	c.7048G>A/c.12028G>A	{"RYR1": {"c.7048G>A": 1, "c.12028G>A": 1}}	\N
7823990	7815081	c.6488G>C/c.7522C>G	{"RYR1": {"c.6488G>C": 1, "c.7522C>G": 1}}	\N
7823991	7815081	c.7063C>T/c.14813T>C	{"RYR1": {"c.7063C>T": 1, "c.14813T>C": 1}}	\N
7823992	7815081	c.7304G>A/c.13918A>G	{"RYR1": {"c.7304G>A": 1, "c.13918A>G": 1}}	\N
7823993	7815081	c.5186T>G/c.7035C>A	{"RYR1": {"c.5186T>G": 1, "c.7035C>A": 1}}	\N
7823994	7815081	c.7124G>C/c.9797T>C	{"RYR1": {"c.7124G>C": 1, "c.9797T>C": 1}}	\N
7823995	7815081	c.97A>G/c.12532G>A	{"RYR1": {"c.97A>G": 1, "c.12532G>A": 1}}	\N
7823996	7815081	c.479A>G/c.1201C>T	{"RYR1": {"c.479A>G": 1, "c.1201C>T": 1}}	\N
7823997	7815081	c.97A>G/c.9797T>C	{"RYR1": {"c.97A>G": 1, "c.9797T>C": 1}}	\N
7823998	7815081	c.7291G>A/c.11416G>A	{"RYR1": {"c.7291G>A": 1, "c.11416G>A": 1}}	\N
7823999	7815081	c.130C>T/c.14639T>C	{"RYR1": {"c.130C>T": 1, "c.14639T>C": 1}}	\N
7824000	7815081	c.488G>A/c.7090T>G	{"RYR1": {"c.488G>A": 1, "c.7090T>G": 1}}	\N
7824001	7815081	c.7360C>T/c.14567C>G	{"RYR1": {"c.7360C>T": 1, "c.14567C>G": 1}}	\N
7824002	7815081	c.8188G>C/c.11969G>T	{"RYR1": {"c.8188G>C": 1, "c.11969G>T": 1}}	\N
7824003	7815081	c.1202G>A/c.13505A>G	{"RYR1": {"c.1202G>A": 1, "c.13505A>G": 1}}	\N
7824004	7815081	c.6488G>C/c.7787C>T	{"RYR1": {"c.6488G>C": 1, "c.7787C>T": 1}}	\N
7824005	7815081	c.131G>A/c.1654C>T	{"RYR1": {"c.131G>A": 1, "c.1654C>T": 1}}	\N
7824006	7815081	c.6387C>G/c.14471T>C	{"RYR1": {"c.6387C>G": 1, "c.14471T>C": 1}}	\N
7824007	7815081	c.6488G>A/c.7355G>A	{"RYR1": {"c.6488G>A": 1, "c.7355G>A": 1}}	\N
7824008	7815081	c.1589G>A/c.14126C>T	{"RYR1": {"c.1589G>A": 1, "c.14126C>T": 1}}	\N
7824009	7815081	c.1475G>A/c.6487C>T	{"RYR1": {"c.1475G>A": 1, "c.6487C>T": 1}}	\N
7824010	7815081	c.2537C>T/c.7282G>A	{"RYR1": {"c.2537C>T": 1, "c.7282G>A": 1}}	\N
7824011	7815081	c.7291G>A/c.14582G>A	{"RYR1": {"c.7291G>A": 1, "c.14582G>A": 1}}	\N
7824012	7815081	c.6488G>A/c.7355G>C	{"RYR1": {"c.6488G>A": 1, "c.7355G>C": 1}}	\N
7824013	7815081	c.178G>A/c.14803G>A	{"RYR1": {"c.178G>A": 1, "c.14803G>A": 1}}	\N
7824014	7815081	c.6488G>C/c.14680G>A	{"RYR1": {"c.6488G>C": 1, "c.14680G>A": 1}}	\N
7824015	7815081	c.7076G>A/c.8189A>G	{"RYR1": {"c.7076G>A": 1, "c.8189A>G": 1}}	\N
7824016	7815081	c.488G>A/c.1202G>A	{"RYR1": {"c.488G>A": 1, "c.1202G>A": 1}}	\N
7824017	7815081	c.7523G>A/c.14387A>G	{"RYR1": {"c.7523G>A": 1, "c.14387A>G": 1}}	\N
7824018	7815081	c.9356G>A/c.11708G>A	{"RYR1": {"c.9356G>A": 1, "c.11708G>A": 1}}	\N
7824019	7815081	c.5183C>T/c.14782A>G	{"RYR1": {"c.5183C>T": 1, "c.14782A>G": 1}}	\N
7824020	7815081	c.946C>T/c.7042_7044delGAG	{"RYR1": {"c.946C>T": 1, "c.7042_7044delGAG": 1}}	\N
7824021	7815081	c.487C>T/c.7099G>A	{"RYR1": {"c.487C>T": 1, "c.7099G>A": 1}}	\N
7824022	7815081	c.7282G>A/c.11518G>A	{"RYR1": {"c.7282G>A": 1, "c.11518G>A": 1}}	\N
7824023	7815081	c.6612C>G/c.7355G>C	{"RYR1": {"c.6612C>G": 1, "c.7355G>C": 1}}	\N
7824024	7815081	c.7035C>A/c.10891G>T	{"RYR1": {"c.7035C>A": 1, "c.10891G>T": 1}}	\N
7824025	7815081	c.3418C>T/c.12149C>A	{"RYR1": {"c.3418C>T": 1, "c.12149C>A": 1}}	\N
7824026	7815081	c.6488G>A/c.7522C>G	{"RYR1": {"c.6488G>A": 1, "c.7522C>G": 1}}	\N
7824027	7815081	c.6612C>G/c.7355G>A	{"RYR1": {"c.6612C>G": 1, "c.7355G>A": 1}}	\N
7824028	7815081	c.6635T>A/c.7372C>T	{"RYR1": {"c.6635T>A": 1, "c.7372C>T": 1}}	\N
7824029	7815081	c.7372C>T/c.9652G>A	{"RYR1": {"c.7372C>T": 1, "c.9652G>A": 1}}	\N
7824030	7815081	c.488G>A/c.1202G>T	{"RYR1": {"c.488G>A": 1, "c.1202G>T": 1}}	\N
7824031	7815081	c.12115A>T/c.14512C>G	{"RYR1": {"c.12115A>T": 1, "c.14512C>G": 1}}	\N
7824032	7815081	c.488G>A/c.5183C>T	{"RYR1": {"c.488G>A": 1, "c.5183C>T": 1}}	\N
7824033	7815081	c.488G>T/c.4400A>G	{"RYR1": {"c.488G>T": 1, "c.4400A>G": 1}}	\N
7824034	7815081	c.7035C>A/c.14680G>A	{"RYR1": {"c.7035C>A": 1, "c.14680G>A": 1}}	\N
7824035	7815081	c.487C>T/c.7018T>C	{"RYR1": {"c.487C>T": 1, "c.7018T>C": 1}}	\N
7824036	7815081	c.6612C>G/c.10237A>T	{"RYR1": {"c.6612C>G": 1, "c.10237A>T": 1}}	\N
7824037	7815081	c.7310C>T/c.8188G>C	{"RYR1": {"c.7310C>T": 1, "c.8188G>C": 1}}	\N
7824038	7815081	c.4747C>T/c.7291G>T	{"RYR1": {"c.4747C>T": 1, "c.7291G>T": 1}}	\N
7824039	7815081	c.1553T>C/c.14545G>A	{"RYR1": {"c.1553T>C": 1, "c.14545G>A": 1}}	\N
7824040	7815081	c.1630G>T/c.5440A>G	{"RYR1": {"c.1630G>T": 1, "c.5440A>G": 1}}	\N
7824041	7815081	c.488G>T/c.14458G>A	{"RYR1": {"c.488G>T": 1, "c.14458G>A": 1}}	\N
7824042	7815081	c.212C>A/c.7042_7044delGAG	{"RYR1": {"c.212C>A": 1, "c.7042_7044delGAG": 1}}	\N
7824043	7815081	c.7084G>A/c.12848A>T	{"RYR1": {"c.7084G>A": 1, "c.12848A>T": 1}}	\N
7824044	7815081	c.6488G>C/c.7355G>C	{"RYR1": {"c.6488G>C": 1, "c.7355G>C": 1}}	\N
7824045	7815081	c.6387C>G/c.14814C>G	{"RYR1": {"c.6387C>G": 1, "c.14814C>G": 1}}	\N
7824046	7815081	c.6488G>C/c.7355G>A	{"RYR1": {"c.6488G>C": 1, "c.7355G>A": 1}}	\N
7824047	7815081	c.497A>G/c.6387C>G	{"RYR1": {"c.497A>G": 1, "c.6387C>G": 1}}	\N
7824048	7815081	c.6617C>T/c.11748T>G	{"RYR1": {"c.6617C>T": 1, "c.11748T>G": 1}}	\N
7824049	7815081	c.38T>G/c.190T>C	{"RYR1": {"c.38T>G": 1, "c.190T>C": 1}}	\N
7824050	7815081	c.14210G>A/c.14680G>A	{"RYR1": {"c.14210G>A": 1, "c.14680G>A": 1}}	\N
7824051	7815081	c.7522C>G/c.11708G>A	{"RYR1": {"c.7522C>G": 1, "c.11708G>A": 1}}	\N
7824052	7815081	c.7360C>T/c.14813T>C	{"RYR1": {"c.7360C>T": 1, "c.14813T>C": 1}}	\N
7824053	7815081	c.4775C>T/c.6349G>C	{"RYR1": {"c.4775C>T": 1, "c.6349G>C": 1}}	\N
7824054	7815081	c.7304G>T/c.12848A>T	{"RYR1": {"c.7304G>T": 1, "c.12848A>T": 1}}	\N
7824055	7815081	c.178G>T/c.14512C>G	{"RYR1": {"c.178G>T": 1, "c.14512C>G": 1}}	\N
7824056	7815081	c.7523G>A/c.13994_13995delTCinsCT	{"RYR1": {"c.7523G>A": 1, "c.13994_13995delTCinsCT": 1}}	\N
7824057	7815081	c.1209C>G/c.6612C>G	{"RYR1": {"c.1209C>G": 1, "c.6612C>G": 1}}	\N
7824058	7815081	c.529C>T/c.14582G>A	{"RYR1": {"c.529C>T": 1, "c.14582G>A": 1}}	\N
7824059	7815081	c.3127C>T/c.7076G>A	{"RYR1": {"c.3127C>T": 1, "c.7076G>A": 1}}	\N
7824060	7815081	c.6617C>T/c.14424C>A	{"RYR1": {"c.6617C>T": 1, "c.14424C>A": 1}}	\N
7824061	7815081	c.4747C>T/c.7291G>A	{"RYR1": {"c.4747C>T": 1, "c.7291G>A": 1}}	\N
7824062	7815081	c.7358T>C/c.13934G>A	{"RYR1": {"c.7358T>C": 1, "c.13934G>A": 1}}	\N
7824063	7815081	c.7358T>C/c.7522C>G	{"RYR1": {"c.7358T>C": 1, "c.7522C>G": 1}}	\N
7824064	7815081	c.12028G>A/c.14210G>A	{"RYR1": {"c.12028G>A": 1, "c.14210G>A": 1}}	\N
7824065	7815081	c.6617C>G/c.12355A>T	{"RYR1": {"c.6617C>G": 1, "c.12355A>T": 1}}	\N
7824066	7815081	c.7304G>T/c.9652G>A	{"RYR1": {"c.7304G>T": 1, "c.9652G>A": 1}}	\N
7824067	7815081	c.6387C>G/c.13672C>T	{"RYR1": {"c.6387C>G": 1, "c.13672C>T": 1}}	\N
7824068	7815081	c.1630G>T/c.11748T>G	{"RYR1": {"c.1630G>T": 1, "c.11748T>G": 1}}	\N
7824069	7815081	c.488G>T/c.14458G>T	{"RYR1": {"c.488G>T": 1, "c.14458G>T": 1}}	\N
7824070	7815081	c.1422G>T/c.7063C>T	{"RYR1": {"c.1422G>T": 1, "c.7063C>T": 1}}	\N
7824071	7815081	c.119G>C/c.14512C>G	{"RYR1": {"c.119G>C": 1, "c.14512C>G": 1}}	\N
7824072	7815081	c.7523G>A/c.9868G>A	{"RYR1": {"c.7523G>A": 1, "c.9868G>A": 1}}	\N
7824073	7815081	c.12149C>A/c.14424C>A	{"RYR1": {"c.12149C>A": 1, "c.14424C>A": 1}}	\N
7824074	7815081	c.1021G>A/c.8005G>A	{"RYR1": {"c.1021G>A": 1, "c.8005G>A": 1}}	\N
7824075	7815081	c.5132A>G/c.14210G>A	{"RYR1": {"c.5132A>G": 1, "c.14210G>A": 1}}	\N
7824076	7815081	c.1840C>T/c.14813T>C	{"RYR1": {"c.1840C>T": 1, "c.14813T>C": 1}}	\N
7824077	7815081	c.152C>A/c.11708G>A	{"RYR1": {"c.152C>A": 1, "c.11708G>A": 1}}	\N
7824078	7815081	c.3527C>T/c.14477C>T	{"RYR1": {"c.3527C>T": 1, "c.14477C>T": 1}}	\N
7824079	7815081	c.7373G>A/c.14782A>G	{"RYR1": {"c.7373G>A": 1, "c.14782A>G": 1}}	\N
7824080	7815081	c.488G>A/c.1841G>T	{"RYR1": {"c.488G>A": 1, "c.1841G>T": 1}}	\N
7824081	7815081	c.1589G>A/c.10252A>G	{"RYR1": {"c.1589G>A": 1, "c.10252A>G": 1}}	\N
7824082	7815081	c.97A>G/c.652G>A	{"RYR1": {"c.97A>G": 1, "c.652G>A": 1}}	\N
7824083	7815081	c.130C>T/c.1209C>G	{"RYR1": {"c.130C>T": 1, "c.1209C>G": 1}}	\N
7824084	7815081	c.982C>T/c.13673G>A	{"RYR1": {"c.982C>T": 1, "c.13673G>A": 1}}	\N
7824085	7815081	c.11126C>T/c.14545G>A	{"RYR1": {"c.11126C>T": 1, "c.14545G>A": 1}}	\N
7824086	7815081	c.1630G>T/c.5024T>C	{"RYR1": {"c.1630G>T": 1, "c.5024T>C": 1}}	\N
7824087	7815081	c.7523G>A/c.13702C>G	{"RYR1": {"c.7523G>A": 1, "c.13702C>G": 1}}	\N
7824088	7815081	c.97A>G/c.14051T>C	{"RYR1": {"c.97A>G": 1, "c.14051T>C": 1}}	\N
7824089	7815081	c.1202G>T/c.8290G>A	{"RYR1": {"c.1202G>T": 1, "c.8290G>A": 1}}	\N
7824090	7815081	c.5890C>T/c.12149C>A	{"RYR1": {"c.5890C>T": 1, "c.12149C>A": 1}}	\N
7824091	7815081	c.119G>C/c.14209C>T	{"RYR1": {"c.119G>C": 1, "c.14209C>T": 1}}	\N
7824092	7815081	c.7372C>T/c.9676G>C	{"RYR1": {"c.7372C>T": 1, "c.9676G>C": 1}}	\N
7824093	7815081	c.14539G>C/c.14813T>C	{"RYR1": {"c.14539G>C": 1, "c.14813T>C": 1}}	\N
7824094	7815081	c.5183C>T/c.15059G>C	{"RYR1": {"c.5183C>T": 1, "c.15059G>C": 1}}	\N
7824095	7815081	c.1841G>T/c.6388G>A	{"RYR1": {"c.1841G>T": 1, "c.6388G>A": 1}}	\N
7824096	7815081	c.3667G>A/c.7291G>T	{"RYR1": {"c.3667G>A": 1, "c.7291G>T": 1}}	\N
7824097	7815081	c.8026C>T/c.13760C>T	{"RYR1": {"c.8026C>T": 1, "c.13760C>T": 1}}	\N
7824098	7815081	c.1840C>T/c.6304G>C	{"RYR1": {"c.1840C>T": 1, "c.6304G>C": 1}}	\N
7824099	7815081	c.1615T>C/c.13913G>A	{"RYR1": {"c.1615T>C": 1, "c.13913G>A": 1}}	\N
7824100	7815081	c.6544A>T/c.7063C>T	{"RYR1": {"c.6544A>T": 1, "c.7063C>T": 1}}	\N
7824101	7815081	c.4763C>T/c.14477C>T	{"RYR1": {"c.4763C>T": 1, "c.14477C>T": 1}}	\N
7824102	7815081	c.1565A>G/c.8926C>T	{"RYR1": {"c.1565A>G": 1, "c.8926C>T": 1}}	\N
7824103	7815081	c.6387C>G/c.14126C>T	{"RYR1": {"c.6387C>G": 1, "c.14126C>T": 1}}	\N
7824104	7815081	c.103T>C/c.131G>A	{"RYR1": {"c.103T>C": 1, "c.131G>A": 1}}	\N
7824105	7815081	c.7035C>A/c.7075C>T	{"RYR1": {"c.7035C>A": 1, "c.7075C>T": 1}}	\N
7824106	7815081	c.12533G>T/c.14477C>T	{"RYR1": {"c.12533G>T": 1, "c.14477C>T": 1}}	\N
7824107	7815081	c.6617C>G/c.7787C>T	{"RYR1": {"c.6617C>G": 1, "c.7787C>T": 1}}	\N
7824108	7815081	c.529C>T/c.12028G>A	{"RYR1": {"c.529C>T": 1, "c.12028G>A": 1}}	\N
7824109	7815081	c.1453A>G/c.11969G>T	{"RYR1": {"c.1453A>G": 1, "c.11969G>T": 1}}	\N
7824110	7815081	c.251C>T/c.1565A>C	{"RYR1": {"c.251C>T": 1, "c.1565A>C": 1}}	\N
7824111	7815081	c.1460T>C/c.1630G>T	{"RYR1": {"c.1460T>C": 1, "c.1630G>T": 1}}	\N
7824112	7815081	c.529C>T/c.3127C>T	{"RYR1": {"c.529C>T": 1, "c.3127C>T": 1}}	\N
7824113	7815081	c.5024T>C/c.7042_7044delGAG	{"RYR1": {"c.5024T>C": 1, "c.7042_7044delGAG": 1}}	\N
7824114	7815081	c.1021G>C/c.8005G>A	{"RYR1": {"c.1021G>C": 1, "c.8005G>A": 1}}	\N
7824115	7815081	c.251C>T/c.1565A>G	{"RYR1": {"c.251C>T": 1, "c.1565A>G": 1}}	\N
7824116	7815081	c.7304G>A/c.8518C>T	{"RYR1": {"c.7304G>A": 1, "c.8518C>T": 1}}	\N
7824117	7815081	c.7304G>T/c.11958C>G	{"RYR1": {"c.7304G>T": 1, "c.11958C>G": 1}}	\N
7824118	7815081	c.12533G>T/c.14512C>G	{"RYR1": {"c.12533G>T": 1, "c.14512C>G": 1}}	\N
7824119	7815081	c.5183C>T/c.15060G>C	{"RYR1": {"c.5183C>T": 1, "c.15060G>C": 1}}	\N
7824120	7815081	c.3166G>C/c.9268G>A	{"RYR1": {"c.3166G>C": 1, "c.9268G>A": 1}}	\N
7824121	7815081	c.5183C>T/c.6388G>A	{"RYR1": {"c.5183C>T": 1, "c.6388G>A": 1}}	\N
7824122	7815081	c.251C>T/c.533A>G	{"RYR1": {"c.251C>T": 1, "c.533A>G": 1}}	\N
7824123	7815081	c.5890C>T/c.7358T>C	{"RYR1": {"c.5890C>T": 1, "c.7358T>C": 1}}	\N
7824124	7815081	c.7300G>A/c.14968A>G	{"RYR1": {"c.7300G>A": 1, "c.14968A>G": 1}}	\N
7824125	7815081	c.6388G>A/c.6502G>A	{"RYR1": {"c.6388G>A": 1, "c.6502G>A": 1}}	\N
7824126	7815081	c.1615T>G/c.6599C>T	{"RYR1": {"c.1615T>G": 1, "c.6599C>T": 1}}	\N
7824127	7815081	c.7084G>A/c.11958C>G	{"RYR1": {"c.7084G>A": 1, "c.11958C>G": 1}}	\N
7824128	7815081	c.7099G>A/c.7372C>T	{"RYR1": {"c.7099G>A": 1, "c.7372C>T": 1}}	\N
7824129	7815081	c.7042_7044delGAG/c.10891G>T	{"RYR1": {"c.10891G>T": 1, "c.7042_7044delGAG": 1}}	\N
7824130	7815081	c.1021G>A/c.8600T>A	{"RYR1": {"c.1021G>A": 1, "c.8600T>A": 1}}	\N
7824131	7815081	c.7360C>T/c.7760A>G	{"RYR1": {"c.7360C>T": 1, "c.7760A>G": 1}}	\N
7824132	7815081	c.7307G>A/c.14539G>C	{"RYR1": {"c.7307G>A": 1, "c.14539G>C": 1}}	\N
7824133	7815081	c.1841G>T/c.14782A>G	{"RYR1": {"c.1841G>T": 1, "c.14782A>G": 1}}	\N
7824134	7815081	c.7358T>C/c.7787C>T	{"RYR1": {"c.7358T>C": 1, "c.7787C>T": 1}}	\N
7824135	7815081	c.6488G>T/c.11748T>G	{"RYR1": {"c.6488G>T": 1, "c.11748T>G": 1}}	\N
7824136	7815081	c.7360C>T/c.10042C>T	{"RYR1": {"c.7360C>T": 1, "c.10042C>T": 1}}	\N
7824137	7815081	c.8026C>T/c.14782A>G	{"RYR1": {"c.8026C>T": 1, "c.14782A>G": 1}}	\N
7824138	7815081	c.7032G>C/c.14918C>T	{"RYR1": {"c.7032G>C": 1, "c.14918C>T": 1}}	\N
7824139	7815081	c.5441T>A/c.7060G>A	{"RYR1": {"c.5441T>A": 1, "c.7060G>A": 1}}	\N
7824140	7815081	c.533A>G/c.6388G>A	{"RYR1": {"c.533A>G": 1, "c.6388G>A": 1}}	\N
7824141	7815081	c.7042_7044delGAG/c.7355G>A	{"RYR1": {"c.7355G>A": 1, "c.7042_7044delGAG": 1}}	\N
7824142	7815081	c.7354C>T/c.9868G>A	{"RYR1": {"c.7354C>T": 1, "c.9868G>A": 1}}	\N
7824143	7815081	c.7042_7044delGAG/c.7355G>C	{"RYR1": {"c.7355G>C": 1, "c.7042_7044delGAG": 1}}	\N
7824144	7815081	c.7291G>A/c.12028G>A	{"RYR1": {"c.7291G>A": 1, "c.12028G>A": 1}}	\N
7824145	7815081	c.2537C>T/c.7304G>T	{"RYR1": {"c.2537C>T": 1, "c.7304G>T": 1}}	\N
7824146	7815081	c.7060G>A/c.14567C>G	{"RYR1": {"c.7060G>A": 1, "c.14567C>G": 1}}	\N
7824147	7815081	c.8518C>T/c.11969G>T	{"RYR1": {"c.8518C>T": 1, "c.11969G>T": 1}}	\N
7824148	7815081	c.8729C>T/c.14803G>A	{"RYR1": {"c.8729C>T": 1, "c.14803G>A": 1}}	\N
7824149	7815081	c.1553T>C/c.7076G>A	{"RYR1": {"c.1553T>C": 1, "c.7076G>A": 1}}	\N
7824150	7815081	c.6757C>T/c.11969G>T	{"RYR1": {"c.6757C>T": 1, "c.11969G>T": 1}}	\N
7824151	7815081	c.7372C>T/c.11958C>G	{"RYR1": {"c.7372C>T": 1, "c.11958C>G": 1}}	\N
7824152	7815081	c.1021G>A/c.14968A>G	{"RYR1": {"c.1021G>A": 1, "c.14968A>G": 1}}	\N
7824153	7815081	c.131G>A/c.14209C>T	{"RYR1": {"c.131G>A": 1, "c.14209C>T": 1}}	\N
7824154	7815081	c.7090T>G/c.8638G>A	{"RYR1": {"c.7090T>G": 1, "c.8638G>A": 1}}	\N
7824155	7815081	c.7063C>T/c.8290G>A	{"RYR1": {"c.7063C>T": 1, "c.8290G>A": 1}}	\N
7824156	7815081	c.526G>A/c.6488G>C	{"RYR1": {"c.526G>A": 1, "c.6488G>C": 1}}	\N
7824157	7815081	c.488G>T/c.1201C>A	{"RYR1": {"c.488G>T": 1, "c.1201C>A": 1}}	\N
7824158	7815081	c.8026C>T/c.12533G>T	{"RYR1": {"c.8026C>T": 1, "c.12533G>T": 1}}	\N
7824159	7815081	c.680A>T/c.12700G>C	{"RYR1": {"c.680A>T": 1, "c.12700G>C": 1}}	\N
7824160	7815081	c.14002C>T/c.14512C>G	{"RYR1": {"c.14002C>T": 1, "c.14512C>G": 1}}	\N
7824161	7815081	c.526G>A/c.6488G>A	{"RYR1": {"c.526G>A": 1, "c.6488G>A": 1}}	\N
7824162	7815081	c.463C>A/c.14693T>C	{"RYR1": {"c.463C>A": 1, "c.14693T>C": 1}}	\N
7824163	7815081	c.488G>T/c.1201C>G	{"RYR1": {"c.488G>T": 1, "c.1201C>G": 1}}	\N
7824164	7815081	c.7099G>A/c.7360C>T	{"RYR1": {"c.7099G>A": 1, "c.7360C>T": 1}}	\N
7824165	7815081	c.496G>A/c.7358T>C	{"RYR1": {"c.496G>A": 1, "c.7358T>C": 1}}	\N
7824166	7815081	c.9310G>A/c.14186A>C	{"RYR1": {"c.9310G>A": 1, "c.14186A>C": 1}}	\N
