NUDT15*17 is assigned no function based on limited evidence. The NUDT15*17 SNV (c.352G>T) results in a premature stop codon(p.E118X) within the Nudix hydrolase domain. Additionally, the stop occurs upstream of c.415C>T, a known "no function" variant. Four out of four variant effect predictors tested by CPIC staff predict that the NUDT15*17 -defining SNV (c.352G>T (p.E118X)) impairs protein function.