CYP2C9*29 is assigned decreased function based on limited evidence. Multiple in vitro studies found CYP2C9*29 demonstrated decreased clearance compared to wildtype (23752738, 23844998, 24118918, 25951663, 25144335, 25476996, 25832633, 25884291, 25924705, 24077631). Although two in vitro studies showed CYP2C9*29 had similar activity compared to wildtype, the experts did not find these results convincing as in these studies CYP2C9*2 which definitively has decreased function, demonstrated increased or similar activity compared to wildtype in these studies (25142737, 27163851). Other studies, however, also showed CYP2C9*29 has similar clearance compared to wildtype (16788382, 25614704). Although the experts recognized there is conflicting evidence, the experts did not find it convincing as it was determined the activity of CYP2C9*29 toward most substrates was similar to CYP2C9*2 which definitively has decreased function. Therefore, consensus among experts was decreased function with an activity value of 0.5.