The NAT2 reference allele has now changed: The NG_012246.1 RefSeq differs from X14672.1 (which was used in the past to define star alleles) at the position that corresponds to c.803 (rs1208), where X14672.1 has "A" while NG_012246.1 has "G". Thus, depending on which reference sequence is utilized, this position is reported as either reference or variant. The transition of allele definitions to the NG_012246.1 RefSeq caused "variant switching", meaning that all star alleles which were previously described as having c.803A>G lost this variant, as "G" is now considered reference, while all other star alleles gained c.803G>A, as "A" is now considered variant.