CYP2D6*36 is assigned no function based on moderate evidence in heterozygous subjects and in vitro studies. CYP2D6*36 has been described in subjects with CYP2D6 *1/*36 and CYP2D6 *2/*36 genotype demonstrating decreased metabolism and subjects with CYP2D6 *4/*36 demonstrating poor metabolism with debrisoquine and dextromethorphan substrates (9918137, 16415111). Multiple in vitro studies found CYP2D6*36 had nondetectable or markedly decreased enzyme activity compared to wildtype with various substrates (7935325, 18784265, 24647041, 30366777). Therefore, consensus among experts was no function with an activity value of 0 based on moderate evidence.