--
--

\restrict HggCO2gs9B0mxkkOraMToUnv6d2ER0HEvqGhvM5sjPevLwYpbD4EwK9neBB3asb


SELECT pg_catalog.set_config('search_path', '', false);

--
-- Name: cpic; Type: SCHEMA; Schema: -; Owner: -
--

CREATE SCHEMA cpic;


--
-- Name: increment_version(); Type: FUNCTION; Schema: cpic; Owner: -
--

CREATE FUNCTION cpic.increment_version() RETURNS trigger
    LANGUAGE plpgsql
    AS $$
BEGIN
  new.version := new.version + 1;
  return new;
END;
$$;


--
-- Name: pharmgkb_guideline_alleles(text); Type: FUNCTION; Schema: cpic; Owner: -
--

CREATE FUNCTION cpic.pharmgkb_guideline_alleles(pharmgkbdrugid text) RETURNS TABLE(genesymbol text, chr text, lookupmethod text, alleles text[])
    LANGUAGE sql STABLE
    AS $$
select
    a.genesymbol,
    g.chr,
    g.lookupmethod,
    array_agg(distinct a.name order by a.name) as alleles
from allele a join gene g on a.genesymbol=g.symbol
where
    a.clinicalfunctionalstatus is not null
    and g.lookupmethod!='ALLELE_STATUS'
    and a.genesymbol in (
        select distinct jsonb_object_keys(p.lookupkey) as genes
        from recommendation p join guideline g on p.guidelineid = g.id join drug d on p.drugid=d.drugid
        where d.pharmgkbid=pharmgkbdrugid
    )
group by a.genesymbol, g.chr, g.lookupmethod
union all
select
    g.symbol as genesymbol,
    g.chr,
    g.lookupmethod,
    array_agg(distinct a.value order by a.value) as alleles
from
    recommendation r
    join drug d on r.drugid = d.drugid,
    jsonb_each_text(r.lookupkey) a
    join gene g on (a.key=g.symbol)
where
    r.allelestatus is not null
    and g.lookupmethod='ALLELE_STATUS'
    and d.pharmgkbid=pharmgkbdrugid
    and upper(a.value) != 'NO RESULT'
group by g.symbol, g.chr, g.lookupmethod
$$;


--
-- Name: FUNCTION pharmgkb_guideline_alleles(pharmgkbdrugid text); Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON FUNCTION cpic.pharmgkb_guideline_alleles(pharmgkbdrugid text) IS 'For a given PharmGKB drug ID, list the alleles that are options for looking up recommendations';


--
-- Name: pharmgkb_guideline_recommendation(text, text); Type: FUNCTION; Schema: cpic; Owner: -
--

CREATE FUNCTION cpic.pharmgkb_guideline_recommendation(drugidarg text, lookupkeyarg text) RETURNS TABLE(drugname text, recommendationid integer, implications jsonb, drugrecommendation text, classification text, phenotypes jsonb, activityscore jsonb, allelestatus jsonb, population text, comments text)
    LANGUAGE sql STABLE
    AS $$
select
    d.name as drugname,
    r.id as recommendationid,
    r.implications,
    r.drugrecommendation,
    r.classification,
    r.phenotypes,
    r.activityscore,
    r.allelestatus,
    r.population,
    r.comments
from recommendation r join drug d on r.drugid = d.drugid join guideline g on r.guidelineid = g.id
where lookupkey <@ (
    select jsonb_object_agg(a.key, coalesce(d.lookupkey -> a.key, a.value)) as lookup
    from
        json_each(lookupkeyArg::json) a
            left join diplotype d on (d.diplotypekey=jsonb_build_object(a.key, a.value))
)
  and d.pharmgkbid=drugidArg
$$;


--
-- Name: FUNCTION pharmgkb_guideline_recommendation(drugidarg text, lookupkeyarg text); Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON FUNCTION cpic.pharmgkb_guideline_recommendation(drugidarg text, lookupkeyarg text) IS 'For a given PharmGKB guideline and genotype lookup JSON key, give the matching recommendations';


--
-- Name: pharmgkb_recommendation(text); Type: FUNCTION; Schema: cpic; Owner: -
--

CREATE FUNCTION cpic.pharmgkb_recommendation(lookupkeyarg text) RETURNS TABLE(drugname text, drugid text, recommendationid integer, implications jsonb, drugrecommendation text, classification text, phenotypes jsonb, activityscore jsonb, allelestatus jsonb, population text, comments text, guidelineurl text)
    LANGUAGE sql STABLE
    AS $$
select
    d.name as drugname,
    d.pharmgkbid as drugid,
    r.id as recommendationid,
    r.implications,
    r.drugrecommendation,
    r.classification,
    r.phenotypes,
    r.activityscore,
    r.allelestatus,
    r.population,
    r.comments,
    g.url as guidelineurl
from recommendation r join drug d on r.drugid = d.drugid join guideline g on r.guidelineid = g.id
where lookupkey <@ (
    select jsonb_object_agg(a.key, coalesce(d.lookupkey -> a.key, a.value)) as lookup
    from
        json_each(lookupKeyArg::json) a
            left join diplotype d on (d.diplotypekey=jsonb_build_object(a.key, a.value))
)
$$;


--
-- Name: FUNCTION pharmgkb_recommendation(lookupkeyarg text); Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON FUNCTION cpic.pharmgkb_recommendation(lookupkeyarg text) IS 'For a given genotype lookup JSON key, give the matching recommendations for all available drugs';


--
-- Name: cpic_id; Type: SEQUENCE; Schema: cpic; Owner: -
--

CREATE SEQUENCE cpic.cpic_id
    START WITH 110000
    INCREMENT BY 1
    NO MINVALUE
    NO MAXVALUE
    CACHE 1;




--
-- Name: drug; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.drug (
    drugid character varying(20) NOT NULL,
    name text NOT NULL,
    pharmgkbid character varying(20),
    rxnormid character varying(20),
    drugbankid character varying(20),
    atcid text[],
    umlscui character varying(20),
    flowchart text,
    version integer DEFAULT 1,
    guidelineid integer
);


--
-- Name: TABLE drug; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.drug IS 'A clinically-used drug.';


--
-- Name: COLUMN drug.drugid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.drug.drugid IS 'A unique identifier for this drug in the form "source:id" where source is some outside knowledge resource and id is their identifier, primary key';


--
-- Name: COLUMN drug.name; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.drug.name IS 'The generic name for this drug, lower-cased, required';


--
-- Name: COLUMN drug.pharmgkbid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.drug.pharmgkbid IS 'The PharmGKB ID for this drug, optional';


--
-- Name: COLUMN drug.rxnormid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.drug.rxnormid IS 'The RxNorm ID for this drug, optional';


--
-- Name: COLUMN drug.drugbankid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.drug.drugbankid IS 'The DrugBank ID for this drug, optional';


--
-- Name: COLUMN drug.atcid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.drug.atcid IS 'One or more ATC IDs for this drug in an array, optional';


--
-- Name: COLUMN drug.umlscui; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.drug.umlscui IS 'The UMLS Concept Unique ID for this drug, optional';


--
-- Name: COLUMN drug.flowchart; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.drug.flowchart IS 'URL for the flow chart image of this drug';


--
-- Name: COLUMN drug.guidelineid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.drug.guidelineid IS 'The guideline this drug is part of a guideline, null means not a part of any guideline';


--
-- Name: guideline; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.guideline (
    id integer DEFAULT nextval('cpic.cpic_id'::regclass) NOT NULL,
    version integer DEFAULT 1,
    name text NOT NULL,
    url text,
    pharmgkbid text[],
    genes text[],
    notesonusage text,
    clinpgxid text
);


--
-- Name: TABLE guideline; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.guideline IS 'A guideline for a drug or group of drugs';


--
-- Name: COLUMN guideline.id; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.guideline.id IS 'A synthetic numerical ID, primary key';


--
-- Name: COLUMN guideline.version; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.guideline.version IS 'The version number, iterates on modification';


--
-- Name: COLUMN guideline.name; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.guideline.name IS 'The name (title) of this guideline, required';


--
-- Name: COLUMN guideline.url; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.guideline.url IS 'The URL of this guideline on the cpicpgx.org domain, optional';


--
-- Name: COLUMN guideline.pharmgkbid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.guideline.pharmgkbid IS 'The IDs from PharmGKB for their annotations of this guideline, optional';


--
-- Name: COLUMN guideline.genes; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.guideline.genes IS 'The subject genes of this guideline';


--
-- Name: COLUMN guideline.notesonusage; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.guideline.notesonusage IS 'Notes about using a particular guideline within this system. This may include. You may find information here when data for a guideline seems missing or incomplete.';


--
-- Name: COLUMN guideline.clinpgxid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.guideline.clinpgxid IS 'The accession ID in ClinPGx for the guideline';


--
-- Name: recommendation; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.recommendation (
    id integer DEFAULT nextval('cpic.cpic_id'::regclass) NOT NULL,
    guidelineid integer,
    drugid character varying(20),
    implications jsonb,
    drugrecommendation text,
    classification character varying(20),
    phenotypes jsonb,
    activityscore jsonb,
    allelestatus jsonb,
    lookupkey jsonb,
    population text,
    comments text,
    version integer DEFAULT 1,
    dosinginformation boolean DEFAULT false,
    alternatedrugavailable boolean DEFAULT false,
    otherprescribingguidance boolean DEFAULT false
);


--
-- Name: TABLE recommendation; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.recommendation IS 'Recommendations for a gene result pulled from a guideline';


--
-- Name: COLUMN recommendation.id; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.recommendation.id IS 'A synthetic numerical ID, auto-assigned, primary key';


--
-- Name: COLUMN recommendation.guidelineid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.recommendation.guidelineid IS 'The guideline this recommendation appears in';


--
-- Name: COLUMN recommendation.drugid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.recommendation.drugid IS 'The drug this recommendation is for';


--
-- Name: COLUMN recommendation.implications; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.recommendation.implications IS 'Implications for phenotypic measures, this is a JSON mapping of gene to implication';


--
-- Name: COLUMN recommendation.drugrecommendation; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.recommendation.drugrecommendation IS 'Dosing or therapeutic recommendations, depending on particular drug';


--
-- Name: COLUMN recommendation.classification; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.recommendation.classification IS 'Classification of recommendations, described in supplementary meterial';


--
-- Name: COLUMN recommendation.phenotypes; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.recommendation.phenotypes IS 'Phenotypes that this recommendation applies to, this is a JSON mapping of gene to phenotype';


--
-- Name: COLUMN recommendation.activityscore; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.recommendation.activityscore IS 'Activity score that this recommendation applies to, this is a JSON mapping of gene to score value';


--
-- Name: COLUMN recommendation.allelestatus; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.recommendation.allelestatus IS 'Whether or not an allele is present, used mainly for HLA genes, and used for recommendation lookups. This is a JSON mapping of gene to allele status (positive/negative)';


--
-- Name: COLUMN recommendation.lookupkey; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.recommendation.lookupkey IS 'A key to use for finding a specific recommendation. Made of a JSON object of gene symbol to key value. The key value can be one of phenotype, activity score, or allele status depending on the gene.';


--
-- Name: COLUMN recommendation.population; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.recommendation.population IS 'The population this recommendation is applicable to';


--
-- Name: COLUMN recommendation.comments; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.recommendation.comments IS 'Optional comments about the recommendation';


--
-- Name: COLUMN recommendation.dosinginformation; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.recommendation.dosinginformation IS 'The guideline recommends a dose adjustment based on genetic variants or phenotypes (e.g. "poor metabolizers") as a primary course of action. However, the guideline may also describe extenuating circumstances where this action is not appropriate.';


--
-- Name: COLUMN recommendation.alternatedrugavailable; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.recommendation.alternatedrugavailable IS 'The guideline recommends that an alternate drug be selected for patients based on genetic variants or phenotypes (e.g. "poor metabolizers") as a primary course of action. However, the guideline may also describe extenuating circumstances where this action is not appropriate.';


--
-- Name: COLUMN recommendation.otherprescribingguidance; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.recommendation.otherprescribingguidance IS 'The guideline and other prescribing guidance not described as either dose adjustment or alternate drug.';


--
-- Name: recommendation_view; Type: VIEW; Schema: cpic; Owner: -
--

CREATE VIEW cpic.recommendation_view AS
 SELECT r.id AS recommendationid,
    r.lookupkey,
    d.name AS drugname,
    g.name AS guidelinename,
    g.url AS guidelineurl,
    r.implications,
    r.drugrecommendation,
    r.classification,
    r.phenotypes,
    r.activityscore,
    r.population,
    r.comments
   FROM ((cpic.recommendation r
     JOIN cpic.drug d ON (((r.drugid)::text = (d.drugid)::text)))
     JOIN cpic.guideline g ON ((r.guidelineid = g.id)));


--
-- Name: VIEW recommendation_view; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON VIEW cpic.recommendation_view IS 'A view to help find recommendation data when querying by the lookupKey';


--
-- Name: recommendation_lookup(text); Type: FUNCTION; Schema: cpic; Owner: -
--

CREATE FUNCTION cpic.recommendation_lookup(diplotypelookup text) RETURNS SETOF cpic.recommendation_view
    LANGUAGE sql STABLE SECURITY DEFINER
    AS $$
select * from cpic.recommendation_view where lookupkey <@ (
    select jsonb_object_agg(key, value) as lookupkey
    from (select lookupkey from cpic.diplotype where diplotypekey <@ diplotypelookup::jsonb) x,
        json_each(x.lookupkey)
)
$$;


--
-- Name: FUNCTION recommendation_lookup(diplotypelookup text); Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON FUNCTION cpic.recommendation_lookup(diplotypelookup text) IS 'This function helps translate diplotypes into recommendation data. This relies on the recommendation_view to gather and filter relevant information. The diplotypelookup parameter is a JSON object of gene symbol to JSON allele representation.';


--
-- Name: test_alert; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.test_alert (
    id integer DEFAULT nextval('cpic.cpic_id'::regclass) NOT NULL,
    population text,
    cdscontext text NOT NULL,
    genes text[],
    phenotype jsonb,
    activityscore jsonb,
    allelestatus jsonb,
    lookupkey jsonb,
    drugid character varying(20),
    alerttext text[] NOT NULL,
    version integer DEFAULT 1
);


--
-- Name: TABLE test_alert; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.test_alert IS 'Example CDS test alert language';


--
-- Name: COLUMN test_alert.id; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.test_alert.id IS 'A synthetic numerical ID, primary key';


--
-- Name: COLUMN test_alert.population; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.test_alert.population IS 'The population this test alert is applicable to: general, adult, pediatrics, unspecified';


--
-- Name: COLUMN test_alert.cdscontext; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.test_alert.cdscontext IS 'This should be either "Pre-test", "Post-test" or "No CDS". This field is non-null';


--
-- Name: COLUMN test_alert.genes; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.test_alert.genes IS 'One or more genes this test alert uses for trigger conditions';


--
-- Name: COLUMN test_alert.phenotype; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.test_alert.phenotype IS 'A JSON object of gene symbol keys to phenotype description';


--
-- Name: COLUMN test_alert.activityscore; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.test_alert.activityscore IS 'A JSON object of gene symbol keys to gene activity score';


--
-- Name: COLUMN test_alert.allelestatus; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.test_alert.allelestatus IS 'Whether or not an allele is present, used mainly for HLA genes. This is a JSON mapping of gene to allele status (positive/negative)';


--
-- Name: COLUMN test_alert.lookupkey; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.test_alert.lookupkey IS 'A key to use for finding a specific test alert. Made of a JSON object of gene symbol to key value. The key value can be one of phenotype, activity score, or allele status depending on the gene.';


--
-- Name: COLUMN test_alert.drugid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.test_alert.drugid IS 'The ID of a drug this alert text is for';


--
-- Name: COLUMN test_alert.alerttext; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.test_alert.alerttext IS 'An array of one or more pieces of alert text';


--
-- Name: test_alert_view; Type: VIEW; Schema: cpic; Owner: -
--

CREATE VIEW cpic.test_alert_view AS
 SELECT t.id AS testalertid,
    t.lookupkey,
    d.name AS drugname,
    t.population,
    t.alerttext,
    t.cdscontext
   FROM (cpic.test_alert t
     JOIN cpic.drug d ON (((t.drugid)::text = (d.drugid)::text)));


--
-- Name: VIEW test_alert_view; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON VIEW cpic.test_alert_view IS 'A view to help find test alert data when querying by the lookupKey';


--
-- Name: test_alert_lookup(text); Type: FUNCTION; Schema: cpic; Owner: -
--

CREATE FUNCTION cpic.test_alert_lookup(lookup text) RETURNS SETOF cpic.test_alert_view
    LANGUAGE sql STABLE SECURITY DEFINER
    AS $$
select * from cpic.test_alert_view where lookupkey <@ (
    select jsonb_object_agg(key, value) as lookupkey
    from (select lookupkey from cpic.diplotype where diplotypekey <@ lookup::jsonb) x,
        json_each(x.lookupkey)
)
$$;


--
-- Name: FUNCTION test_alert_lookup(lookup text); Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON FUNCTION cpic.test_alert_lookup(lookup text) IS 'This function helps translate diplotypes into test alert data. This relies on the test_alert_view to gather and filter relevant information. The lookup parameter is a JSON object of gene symbol to JSON allele representation.';


--
-- Name: allele; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.allele (
    id integer DEFAULT nextval('cpic.cpic_id'::regclass) NOT NULL,
    version integer DEFAULT 1,
    genesymbol character varying(50) NOT NULL,
    name text NOT NULL,
    functionalstatus text,
    clinicalfunctionalstatus text,
    clinicalfunctionalsubstrate text,
    activityvalue character varying(50),
    definitionid integer NOT NULL,
    citations text[],
    strength text,
    functioncomments text,
    findings text,
    frequency jsonb,
    inferredfrequency boolean DEFAULT false
);


--
-- Name: TABLE allele; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.allele IS 'An allele of a gene';


--
-- Name: COLUMN allele.id; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele.id IS 'A synthetic numerical ID, auto-assigned, primary key';


--
-- Name: COLUMN allele.version; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele.version IS 'The version number, iterates on modification';


--
-- Name: COLUMN allele.genesymbol; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele.genesymbol IS 'The HGNC symbol of the gene the allele is for, required';


--
-- Name: COLUMN allele.name; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele.name IS 'The name of this allele, required';


--
-- Name: COLUMN allele.functionalstatus; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele.functionalstatus IS 'The functional phenotype of this allele';


--
-- Name: COLUMN allele.clinicalfunctionalstatus; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele.clinicalfunctionalstatus IS 'The functional phenotype of this allele used for clinical systems';


--
-- Name: COLUMN allele.clinicalfunctionalsubstrate; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele.clinicalfunctionalsubstrate IS 'Allele clinical function substrate specificity, optional';


--
-- Name: COLUMN allele.activityvalue; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele.activityvalue IS 'Descriptor of activity score, optional';


--
-- Name: COLUMN allele.definitionid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele.definitionid IS 'The reference to the definition for this allele';


--
-- Name: COLUMN allele.citations; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele.citations IS 'An array of PubMed IDs use as citations for this functional assignment';


--
-- Name: COLUMN allele.strength; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele.strength IS 'The strength of evidence';


--
-- Name: COLUMN allele.functioncomments; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele.functioncomments IS 'Comments this functional assignment of this allele';


--
-- Name: COLUMN allele.inferredfrequency; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele.inferredfrequency IS 'Indicates (with "true") that the frequencies for this allele have been inferred by an algorithm that aggregates the frequencies for other alleles of this gene and is not based on direct data, defaults to false, should only be 1 per gene';


--
-- Name: allele_definition; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.allele_definition (
    id integer DEFAULT nextval('cpic.cpic_id'::regclass) NOT NULL,
    version integer DEFAULT 1,
    genesymbol character varying(50) NOT NULL,
    name text NOT NULL,
    pharmvarid character varying(50),
    matchesreferencesequence boolean DEFAULT false,
    structuralvariation boolean DEFAULT false
);


--
-- Name: TABLE allele_definition; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.allele_definition IS 'The definition for an allele of a gene';


--
-- Name: COLUMN allele_definition.id; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele_definition.id IS 'A synthetic numerical ID, auto-assigned, primary key';


--
-- Name: COLUMN allele_definition.genesymbol; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele_definition.genesymbol IS 'The HGNC symbol of the gene the allele is for, required';


--
-- Name: COLUMN allele_definition.name; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele_definition.name IS 'The name of this allele, required';


--
-- Name: COLUMN allele_definition.pharmvarid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele_definition.pharmvarid IS 'The PharmVar core allele ID for this allele';


--
-- Name: COLUMN allele_definition.matchesreferencesequence; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele_definition.matchesreferencesequence IS 'Indicates (with "true") the variants that define the named allele will match the reference sequence for the gene, defaults to false, should only be 1 per gene';


--
-- Name: COLUMN allele_definition.structuralvariation; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele_definition.structuralvariation IS 'Indicates whether this allele definition is a structural variant, default is false. If true, look in the pharmvarid field for the PharmVar ID that defines the structural variation.';


--
-- Name: allele_frequency; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.allele_frequency (
    alleleid integer NOT NULL,
    population integer NOT NULL,
    frequency numeric,
    label text,
    version integer DEFAULT 1
);


--
-- Name: TABLE allele_frequency; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.allele_frequency IS 'A frequency observation for a particular allele in a particular population';


--
-- Name: COLUMN allele_frequency.alleleid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele_frequency.alleleid IS 'The ID of the allele for this observation';


--
-- Name: COLUMN allele_frequency.population; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele_frequency.population IS 'The ID of the population for this observation';


--
-- Name: COLUMN allele_frequency.frequency; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele_frequency.frequency IS 'The numeric representation of this frequency';


--
-- Name: COLUMN allele_frequency.label; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele_frequency.label IS 'The textual label for this frequency, "-" means no observation made';


--
-- Name: COLUMN allele_frequency.version; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele_frequency.version IS 'The version number, iterates on modification';


--
-- Name: pair; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.pair (
    pairid integer DEFAULT nextval('cpic.cpic_id'::regclass) NOT NULL,
    genesymbol character varying(20),
    drugid character varying(20),
    guidelineid integer,
    usedforrecommendation boolean DEFAULT false,
    version integer DEFAULT 1,
    cpiclevel character varying(5) NOT NULL,
    pgkbcalevel character varying(5),
    pgxtesting text,
    citations text[],
    removed boolean DEFAULT false,
    removeddate date,
    removedreason text,
    CONSTRAINT valid_cpiclevel_check CHECK (((cpiclevel)::text = ANY (ARRAY[('A'::character varying)::text, ('A/B'::character varying)::text, ('B'::character varying)::text, ('B/C'::character varying)::text, ('C'::character varying)::text, ('C/D'::character varying)::text, ('D'::character varying)::text]))),
    CONSTRAINT valid_pgkblevel_check CHECK (((pgkbcalevel)::text = ANY (ARRAY[('1A'::character varying)::text, ('1B'::character varying)::text, ('2A'::character varying)::text, ('2B'::character varying)::text, ('3'::character varying)::text, ('4'::character varying)::text]))),
    CONSTRAINT valid_pmids CHECK ((array_to_string(citations, ''::text) ~ '\d+'::text)),
    CONSTRAINT valid_used_check CHECK (((NOT usedforrecommendation) OR (guidelineid IS NOT NULL)))
);


--
-- Name: TABLE pair; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.pair IS 'A pair of a gene and a drug that is notable to CPIC';


--
-- Name: COLUMN pair.pairid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair.pairid IS 'A synthetic numerical id, automatically assigned, primary key';


--
-- Name: COLUMN pair.genesymbol; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair.genesymbol IS 'The HGNC symbol of the gene in this pair, required';


--
-- Name: COLUMN pair.drugid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair.drugid IS 'The ID of the drug in this pair, required';


--
-- Name: COLUMN pair.guidelineid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair.guidelineid IS 'The ID of a guideline this pair is described in, optional';


--
-- Name: COLUMN pair.usedforrecommendation; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair.usedforrecommendation IS 'Whether the gene is used for recommendation lookup for the drug if this pair is part of a guideline, default false';


--
-- Name: COLUMN pair.version; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair.version IS 'The version number, iterates on modification';


--
-- Name: COLUMN pair.cpiclevel; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair.cpiclevel IS 'The CPIC level of this pair, required';


--
-- Name: COLUMN pair.pgkbcalevel; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair.pgkbcalevel IS 'The top level of PharmGKB Clinical Annotation for this pair, optional';


--
-- Name: COLUMN pair.pgxtesting; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair.pgxtesting IS 'The top level of PGx testing recommendation from PharmGKB label annotations, optional';


--
-- Name: COLUMN pair.citations; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair.citations IS 'The PMID citations in an array for this pair, optional';


--
-- Name: COLUMN pair.removed; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair.removed IS 'Has this pair been "removed", eg is no longer a valid pair, default false';


--
-- Name: COLUMN pair.removeddate; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair.removeddate IS 'If removed, when was this pair "removed"';


--
-- Name: COLUMN pair.removedreason; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair.removedreason IS 'If removed, why was this pair "removed"';


--
-- Name: allele_guideline_view; Type: VIEW; Schema: cpic; Owner: -
--

CREATE VIEW cpic.allele_guideline_view AS
 SELECT DISTINCT a.genesymbol,
    a.name AS allele_name,
    g.name AS guideline_name,
    g.url AS guideline_url
   FROM ((cpic.allele a
     JOIN cpic.pair p ON (((a.genesymbol)::text = (p.genesymbol)::text)))
     JOIN cpic.guideline g ON ((g.id = p.guidelineid)))
  WHERE (a.clinicalfunctionalstatus IS NOT NULL);


--
-- Name: VIEW allele_guideline_view; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON VIEW cpic.allele_guideline_view IS 'A combination of alleles and the guidelines they appear in';


--
-- Name: COLUMN allele_guideline_view.genesymbol; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele_guideline_view.genesymbol IS 'The HGNC symbol of the gene';


--
-- Name: COLUMN allele_guideline_view.allele_name; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele_guideline_view.allele_name IS 'The name of the allele';


--
-- Name: COLUMN allele_guideline_view.guideline_name; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele_guideline_view.guideline_name IS 'The name of the guideline this allele appears in';


--
-- Name: COLUMN allele_guideline_view.guideline_url; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele_guideline_view.guideline_url IS 'The URL to the guideline';


--
-- Name: allele_location_value; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.allele_location_value (
    alleledefinitionid integer NOT NULL,
    locationid integer NOT NULL,
    variantallele text NOT NULL,
    version integer DEFAULT 1
);


--
-- Name: TABLE allele_location_value; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.allele_location_value IS 'The change at a specific location for a specific allele';


--
-- Name: COLUMN allele_location_value.alleledefinitionid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele_location_value.alleledefinitionid IS 'The reference to the allele this variant is on';


--
-- Name: COLUMN allele_location_value.locationid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele_location_value.locationid IS 'The reference to the location this variant is for';


--
-- Name: COLUMN allele_location_value.variantallele; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele_location_value.variantallele IS 'The allele of this location for the allele';


--
-- Name: COLUMN allele_location_value.version; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.allele_location_value.version IS 'The version number, iterates on modification';


--
-- Name: change_log; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.change_log (
    date date NOT NULL,
    type text NOT NULL,
    entityid text,
    note text NOT NULL,
    version integer DEFAULT 1,
    deployedrelease text
);


--
-- Name: TABLE change_log; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.change_log IS 'A dated freeform text description of a change made to a type of information and optionally for a specific entity';


--
-- Name: COLUMN change_log.date; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.change_log.date IS 'The date the log note is applicable';


--
-- Name: COLUMN change_log.type; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.change_log.type IS 'The type of data this log message is about';


--
-- Name: COLUMN change_log.entityid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.change_log.entityid IS 'Optional, the specific entity this note is about. For example, could be a gene symbol or drug ID';


--
-- Name: COLUMN change_log.note; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.change_log.note IS 'The freeform text note about what the change was';


--
-- Name: COLUMN change_log.version; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.change_log.version IS 'The version number, iterates on modification';


--
-- Name: COLUMN change_log.deployedrelease; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.change_log.deployedrelease IS 'The release this change was deployed with';


--
-- Name: gene; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.gene (
    symbol character varying(20) NOT NULL,
    chr character varying(20),
    genesequenceid text,
    proteinsequenceid text,
    chromosequenceid text,
    mrnasequenceid text,
    hgncid text,
    ncbiid text,
    ensemblid text,
    pharmgkbid text,
    frequencymethods text,
    lookupmethod text DEFAULT 'PHENOTYPE'::text,
    version integer DEFAULT 1,
    notesondiplotype text,
    url text,
    functionmethods text,
    notesonallelenaming text,
    includephenotypefrequencies boolean DEFAULT true NOT NULL,
    includediplotypefrequencies boolean DEFAULT true NOT NULL,
    CONSTRAINT gene_chr_check CHECK (((chr)::text ~ '^chr\S+$'::text)),
    CONSTRAINT gene_chromosequenceid_check CHECK ((chromosequenceid ~ '^(NC_\S+)?$'::text)),
    CONSTRAINT gene_ensemblid_check CHECK ((ensemblid ~ '^(ENSG\d+)?$'::text)),
    CONSTRAINT gene_genesequenceid_check CHECK ((genesequenceid ~ '^(NG_\S+)?$'::text)),
    CONSTRAINT gene_hgncid_check CHECK ((hgncid ~ '^(HGNC:\d+)?$'::text)),
    CONSTRAINT gene_mrnasequenceid_check CHECK ((mrnasequenceid ~ '^(NM_\S+)?$'::text)),
    CONSTRAINT gene_pharmgkbid_check CHECK ((pharmgkbid ~ '^(PA\d+)?$'::text)),
    CONSTRAINT gene_proteinsequenceid_check CHECK ((proteinsequenceid ~ '^(NP_\S+)?$'::text))
);


--
-- Name: TABLE gene; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.gene IS 'Gene information with a primary key of the approved HGNC symbol for the gene. This means any gene used in the table must be approved by HGNC.';


--
-- Name: COLUMN gene.symbol; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene.symbol IS 'Approved HGNC symbol, primary key.';


--
-- Name: COLUMN gene.chr; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene.chr IS 'Chromosome symbol. In the form chr##, where ## is the number or X/Y.';


--
-- Name: COLUMN gene.genesequenceid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene.genesequenceid IS 'The RefSeq ID for the sequence that represents this gene, starts with "NG_". No version suffix.';


--
-- Name: COLUMN gene.proteinsequenceid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene.proteinsequenceid IS 'The RefSeq ID for the sequence that represents the protein product of this gene, starts with "NP_". No version suffix.';


--
-- Name: COLUMN gene.chromosequenceid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene.chromosequenceid IS 'The RefSeq ID for the sequence that represents the chromosome this gene is on, starts with "NC_". No version suffix.';


--
-- Name: COLUMN gene.mrnasequenceid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene.mrnasequenceid IS 'The RefSeq ID for the sequence that represents the translation of this gene, starts with "NM_". No version suffix.';


--
-- Name: COLUMN gene.hgncid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene.hgncid IS 'The HGNC numerical ID number for this gene prefixed by "HGNC:"';


--
-- Name: COLUMN gene.ncbiid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene.ncbiid IS 'The NCBI Gene (Entrez) ID number for this gene';


--
-- Name: COLUMN gene.ensemblid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene.ensemblid IS 'The Ensembl ID for this gene';


--
-- Name: COLUMN gene.pharmgkbid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene.pharmgkbid IS 'The ID for this gene in PharmGKB.';


--
-- Name: COLUMN gene.frequencymethods; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene.frequencymethods IS 'Text documentation of the methods and caveats for allele frequency data';


--
-- Name: COLUMN gene.lookupmethod; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene.lookupmethod IS 'The way to lookup information about diplotypes of this gene, should use ACTIVITY_SCORE, PHENOTYPE, or ALLELE_STATUS';


--
-- Name: COLUMN gene.notesondiplotype; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene.notesondiplotype IS 'Optional notes about the diplotypes of the gene';


--
-- Name: COLUMN gene.includephenotypefrequencies; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene.includephenotypefrequencies IS 'if allele frequencies exist for this gene, whether to calculate and display phenotype-level frequencies. a true value does not imply existence frequency data';


--
-- Name: COLUMN gene.includediplotypefrequencies; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene.includediplotypefrequencies IS 'if allele frequencies exist for this gene, whether to calculate and display diplotype-level frequencies. a true value does not imply existence frequency data';


--
-- Name: change_log_view; Type: VIEW; Schema: cpic; Owner: -
--

CREATE VIEW cpic.change_log_view AS
 WITH x AS (
         SELECT gene.symbol AS entityid,
            gene.symbol AS entityname
           FROM cpic.gene
        UNION ALL
         SELECT drug.drugid AS entityid,
            drug.name AS entityname
           FROM cpic.drug
        )
 SELECT l.date,
    l.type,
    x.entityname,
    l.note,
    l.deployedrelease
   FROM (cpic.change_log l
     LEFT JOIN x ON ((l.entityid = (x.entityid)::text)));


--
-- Name: VIEW change_log_view; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON VIEW cpic.change_log_view IS 'This view of the change_log table add the entity name to make it more readable';


--
-- Name: gene_result; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.gene_result (
    id integer DEFAULT nextval('cpic.cpic_id'::regclass) NOT NULL,
    genesymbol character varying(50) NOT NULL,
    result text NOT NULL,
    activityscore text,
    ehrpriority text,
    consultationtext text,
    version integer DEFAULT 1,
    frequency jsonb
);


--
-- Name: TABLE gene_result; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.gene_result IS 'Possible phenotype values for a gene. The gene + phenotype + activity score should be unique.';


--
-- Name: COLUMN gene_result.id; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene_result.id IS 'A synthetic numerical ID, auto-assigned, primary key';


--
-- Name: COLUMN gene_result.genesymbol; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene_result.genesymbol IS 'The HGNC symbol of the gene in this pair, required';


--
-- Name: COLUMN gene_result.result; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene_result.result IS 'The result for a gene, can either be a phenotype or "allele status" depending on the lookup method for the gene (see lookupMethod in gene table), required';


--
-- Name: COLUMN gene_result.activityscore; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene_result.activityscore IS 'Activity score, optional';


--
-- Name: COLUMN gene_result.ehrpriority; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene_result.ehrpriority IS 'EHR Priority Result, optional';


--
-- Name: COLUMN gene_result.consultationtext; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene_result.consultationtext IS 'Consultation (Interpretation) Text Provided with Test Result';


--
-- Name: COLUMN gene_result.frequency; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene_result.frequency IS 'JSON map of frequencies for this gene result with keys being biogeographical groups';


--
-- Name: gene_result_diplotype; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.gene_result_diplotype (
    id integer DEFAULT nextval('cpic.cpic_id'::regclass) NOT NULL,
    functionphenotypeid integer NOT NULL,
    diplotype text NOT NULL,
    diplotypekey jsonb NOT NULL,
    frequency jsonb
);


--
-- Name: TABLE gene_result_diplotype; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.gene_result_diplotype IS 'Specific diplotypes that are associated with a gene result. This table is a child of gene_result_lookup and distantly of gene_result';


--
-- Name: COLUMN gene_result_diplotype.id; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene_result_diplotype.id IS 'A synthetic numerical ID, auto-assigned, primary key';


--
-- Name: COLUMN gene_result_diplotype.functionphenotypeid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene_result_diplotype.functionphenotypeid IS 'An ID referencing a gene_result_lookup record, required';


--
-- Name: COLUMN gene_result_diplotype.diplotype; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene_result_diplotype.diplotype IS 'A diplotype for the gene in the form Allele1/Allele2, required';


--
-- Name: COLUMN gene_result_diplotype.diplotypekey; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene_result_diplotype.diplotypekey IS 'A normalized JSON version of the diplotype for use in lookups. Should be an object with the allele names as properties and the counts as the values. Required';


--
-- Name: gene_result_lookup; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.gene_result_lookup (
    id integer DEFAULT nextval('cpic.cpic_id'::regclass) NOT NULL,
    phenotypeid integer NOT NULL,
    lookupkey jsonb NOT NULL,
    function1 text,
    function2 text,
    activityvalue1 text,
    activityvalue2 text,
    totalactivityscore text,
    description text
);


--
-- Name: TABLE gene_result_lookup; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.gene_result_lookup IS 'Gene descriptions that, when combined, link to a gene result. This table is a child of gene_result.';


--
-- Name: COLUMN gene_result_lookup.id; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene_result_lookup.id IS 'A synthetic numerical ID, auto-assigned, primary key';


--
-- Name: COLUMN gene_result_lookup.phenotypeid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene_result_lookup.phenotypeid IS 'An ID referencing the gene_result this is associated with, required';


--
-- Name: COLUMN gene_result_lookup.lookupkey; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene_result_lookup.lookupkey IS 'A normalized JSON format of the data used to lookup a diplotype. The keys of this field are either the functions, activity scores, or allele statuses depending on what the gene requires. Required.';


--
-- Name: COLUMN gene_result_lookup.function1; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene_result_lookup.function1 IS 'The first allele function';


--
-- Name: COLUMN gene_result_lookup.function2; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene_result_lookup.function2 IS 'The second allele function';


--
-- Name: COLUMN gene_result_lookup.activityvalue1; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene_result_lookup.activityvalue1 IS 'The activity score for the first allele function';


--
-- Name: COLUMN gene_result_lookup.activityvalue2; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene_result_lookup.activityvalue2 IS 'The activity score for the second allele function';


--
-- Name: COLUMN gene_result_lookup.totalactivityscore; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene_result_lookup.totalactivityscore IS 'The sum activity score for the functions';


--
-- Name: COLUMN gene_result_lookup.description; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.gene_result_lookup.description IS 'A description of the diplotypes associated with this phenotype';


--
-- Name: diplotype; Type: VIEW; Schema: cpic; Owner: -
--

CREATE VIEW cpic.diplotype AS
 SELECT gp.genesymbol,
    d.diplotype,
    pf.function1,
    pf.function2,
    pf.activityvalue1,
    pf.activityvalue2,
    pf.totalactivityscore,
    pf.description,
    d.diplotypekey,
    gp.result AS generesult,
    gp.ehrpriority,
    gp.consultationtext,
    json_build_object(gp.genesymbol,
        CASE
            WHEN (g.lookupmethod = 'ACTIVITY_SCORE'::text) THEN pf.totalactivityscore
            ELSE gp.result
        END) AS lookupkey
   FROM (((cpic.gene_result_diplotype d
     JOIN cpic.gene_result_lookup pf ON ((d.functionphenotypeid = pf.id)))
     JOIN cpic.gene_result gp ON ((pf.phenotypeid = gp.id)))
     JOIN cpic.gene g ON (((gp.genesymbol)::text = (g.symbol)::text)));


--
-- Name: VIEW diplotype; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON VIEW cpic.diplotype IS 'A combination of gene_result and gene_result_diplotype that allows you to easily query by diplotype and see the phenotype-related data for it';


--
-- Name: COLUMN diplotype.genesymbol; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.diplotype.genesymbol IS 'The HGNC symbol of the gene in this pair, required';


--
-- Name: COLUMN diplotype.diplotype; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.diplotype.diplotype IS 'A diplotype for the gene in the form Allele1/Allele2, required';


--
-- Name: COLUMN diplotype.function1; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.diplotype.function1 IS 'A functional assignment of one of the alleles, optional';


--
-- Name: COLUMN diplotype.function2; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.diplotype.function2 IS 'A functional assignment of one of the alleles, optional';


--
-- Name: COLUMN diplotype.activityvalue1; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.diplotype.activityvalue1 IS 'An activity value assignment of one of the alleles, optional';


--
-- Name: COLUMN diplotype.activityvalue2; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.diplotype.activityvalue2 IS 'An activity value assignment of one of the alleles, optional';


--
-- Name: COLUMN diplotype.totalactivityscore; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.diplotype.totalactivityscore IS 'The total Activity Score number, optional';


--
-- Name: COLUMN diplotype.description; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.diplotype.description IS 'The long-form description of the diplotype';


--
-- Name: COLUMN diplotype.diplotypekey; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.diplotype.diplotypekey IS 'A normalized version of the diplotype that can be used for DB lookups';


--
-- Name: COLUMN diplotype.generesult; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.diplotype.generesult IS 'The result for a gene, can either be a phenotype or "allele status" depending on the lookup method for the gene (see lookupMethod in gene table), required';


--
-- Name: COLUMN diplotype.lookupkey; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.diplotype.lookupkey IS 'A normalized version of the gene phenotype that can be used for recommendation or test alert lookup';


--
-- Name: data_progress; Type: VIEW; Schema: cpic; Owner: -
--

CREATE VIEW cpic.data_progress AS
 SELECT 'Gene'::text AS object_class,
    'Allele Definition Data'::text AS data_type,
    allele_definition.genesymbol AS object_name,
    count(*) AS n
   FROM cpic.allele_definition
  GROUP BY allele_definition.genesymbol
UNION ALL
 SELECT 'Gene'::text AS object_class,
    'Allele Functionality Data'::text AS data_type,
    a.genesymbol AS object_name,
    count(*) AS n
   FROM cpic.allele a
  WHERE (a.clinicalfunctionalstatus IS NOT NULL)
  GROUP BY a.genesymbol
UNION ALL
 SELECT 'Gene'::text AS object_class,
    'Diplotype to Phenotype Data'::text AS data_type,
    diplotype.genesymbol AS object_name,
    count(*) AS n
   FROM cpic.diplotype
  GROUP BY diplotype.genesymbol
UNION ALL
 SELECT 'Gene'::text AS object_class,
    'Frequency Data'::text AS data_type,
    a.genesymbol AS object_name,
    count(*) AS n
   FROM (cpic.allele_frequency f
     JOIN cpic.allele a ON ((f.alleleid = a.id)))
  GROUP BY a.genesymbol
UNION ALL
 SELECT 'Gene'::text AS object_class,
    'Gene CDS Data'::text AS data_type,
    gene_result.genesymbol AS object_name,
    count(*) AS n
   FROM cpic.gene_result
  WHERE (gene_result.consultationtext IS NOT NULL)
  GROUP BY gene_result.genesymbol
UNION ALL
 SELECT 'Gene'::text AS object_class,
    'Gene Phenotype Data'::text AS data_type,
    g.genesymbol AS object_name,
    count(*) AS n
   FROM (cpic.gene_result g
     JOIN cpic.gene_result_lookup pf ON ((g.id = pf.phenotypeid)))
  GROUP BY g.genesymbol
UNION ALL
 SELECT 'Gene'::text AS object_class,
    'PharmVar Allele IDs'::text AS data_type,
    a.genesymbol AS object_name,
    count(*) AS n
   FROM cpic.allele_definition a
  WHERE (a.pharmvarid IS NOT NULL)
  GROUP BY a.genesymbol
UNION ALL
 SELECT 'Drug'::text AS object_class,
    'Flowcharts'::text AS data_type,
    drug.name AS object_name,
    count(*) AS n
   FROM cpic.drug
  WHERE (drug.flowchart IS NOT NULL)
  GROUP BY drug.name
UNION ALL
 SELECT 'Drug'::text AS object_class,
    'Table 2 Recommendations'::text AS data_type,
    d.name AS object_name,
    count(DISTINCT r.id) AS n
   FROM (cpic.recommendation r
     JOIN cpic.drug d ON (((r.drugid)::text = (d.drugid)::text)))
  GROUP BY d.name
UNION ALL
 SELECT 'Drug'::text AS object_class,
    'Drug Test Alerts'::text AS data_type,
    d.name AS object_name,
    count(DISTINCT t.id) AS n
   FROM (cpic.test_alert t
     JOIN cpic.drug d ON (((t.drugid)::text = (d.drugid)::text)))
  GROUP BY d.name
UNION ALL
 SELECT 'Drug'::text AS object_class,
    'Guideline'::text AS data_type,
    d.name AS object_name,
    count(DISTINCT g.id) AS n
   FROM ((cpic.guideline g
     JOIN cpic.pair p ON ((g.id = p.guidelineid)))
     JOIN cpic.drug d ON (((p.drugid)::text = (d.drugid)::text)))
  GROUP BY d.name;


--
-- Name: file_artifact; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.file_artifact (
    id integer DEFAULT nextval('cpic.cpic_id'::regclass) NOT NULL,
    entityids text[],
    type text NOT NULL,
    filename text NOT NULL,
    url text
);


--
-- Name: TABLE file_artifact; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.file_artifact IS 'File artifact information. Each entry is a different file artifact generated by the system';


--
-- Name: COLUMN file_artifact.id; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.file_artifact.id IS 'A synthetic numerical ID, auto-assigned, primary key';


--
-- Name: COLUMN file_artifact.entityids; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.file_artifact.entityids IS 'The IDs of the entities the file is for, required';


--
-- Name: COLUMN file_artifact.type; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.file_artifact.type IS 'The type of file';


--
-- Name: COLUMN file_artifact.filename; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.file_artifact.filename IS 'The name of the file (no path)';


--
-- Name: COLUMN file_artifact.url; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.file_artifact.url IS 'The permanent URL of the current version of this file';


--
-- Name: file_artifact_history; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.file_artifact_history (
    id integer DEFAULT nextval('cpic.cpic_id'::regclass) NOT NULL,
    fileid integer NOT NULL,
    source text NOT NULL,
    changedate timestamp without time zone DEFAULT CURRENT_TIMESTAMP NOT NULL,
    changemessage text
);


--
-- Name: TABLE file_artifact_history; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.file_artifact_history IS 'History information for a related file artifact';


--
-- Name: COLUMN file_artifact_history.id; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.file_artifact_history.id IS 'A synthetic numerical ID, auto-assigned, primary key';


--
-- Name: COLUMN file_artifact_history.fileid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.file_artifact_history.fileid IS 'The ID of the related File Artifact';


--
-- Name: COLUMN file_artifact_history.source; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.file_artifact_history.source IS 'Where this history message originated from';


--
-- Name: COLUMN file_artifact_history.changedate; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.file_artifact_history.changedate IS 'The date the change was applied';


--
-- Name: COLUMN file_artifact_history.changemessage; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.file_artifact_history.changemessage IS 'A message describing the change that occurred';


--
-- Name: file_note; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.file_note (
    type text NOT NULL,
    entityid text,
    note text NOT NULL,
    ordinal integer NOT NULL,
    version integer DEFAULT 1
);


--
-- Name: TABLE file_note; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.file_note IS 'An ordered note that should appear with the type of information specified';


--
-- Name: COLUMN file_note.type; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.file_note.type IS 'The type of information this note is about';


--
-- Name: COLUMN file_note.entityid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.file_note.entityid IS 'Optional, the specific entity this note is about. For example, could be a gene symbol or drug ID';


--
-- Name: COLUMN file_note.note; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.file_note.note IS 'The freeform text note about the type/entity';


--
-- Name: COLUMN file_note.ordinal; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.file_note.ordinal IS 'The index number for ordering notes of a given type/entity';


--
-- Name: COLUMN file_note.version; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.file_note.version IS 'The version number, iterates on modification';


--
-- Name: file_status; Type: VIEW; Schema: cpic; Owner: -
--

CREATE VIEW cpic.file_status AS
 SELECT a.id,
    a.entityids,
    a.type,
    a.filename,
    a.url,
    history.latest_change
   FROM (cpic.file_artifact a
     LEFT JOIN ( SELECT h.fileid,
            max(h.changedate) AS latest_change
           FROM cpic.file_artifact_history h
          GROUP BY h.fileid) history ON ((a.id = history.fileid)))
  ORDER BY a.type, a.filename;


--
-- Name: flyway_schema_history; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.flyway_schema_history (
    installed_rank integer NOT NULL,
    version character varying(50),
    description character varying(200) NOT NULL,
    type character varying(20) NOT NULL,
    script character varying(1000) NOT NULL,
    checksum integer,
    installed_by character varying(100) NOT NULL,
    installed_on timestamp without time zone DEFAULT now() NOT NULL,
    execution_time integer NOT NULL,
    success boolean NOT NULL
);


--
-- Name: guideline_summary_view; Type: VIEW; Schema: cpic; Owner: -
--

CREATE VIEW cpic.guideline_summary_view AS
 SELECT g.name AS guideline_name,
    g.url AS guideline_url,
    array_agg(DISTINCT d.name) AS drugs,
    jsonb_agg(DISTINCT jsonb_build_object('symbol', p.genesymbol, 'url', (('https://cpicpgx.org/gene/'::text || lower((p.genesymbol)::text)) || '/'::text))) AS genes
   FROM ((cpic.guideline g
     JOIN cpic.pair p ON ((g.id = p.guidelineid)))
     JOIN cpic.drug d ON (((p.drugid)::text = (d.drugid)::text)))
  GROUP BY g.name, g.url;


--
-- Name: VIEW guideline_summary_view; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON VIEW cpic.guideline_summary_view IS 'This view lists guidelines and the genes and drugs that are associated with them';


--
-- Name: COLUMN guideline_summary_view.guideline_name; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.guideline_summary_view.guideline_name IS 'The title of the guideline';


--
-- Name: COLUMN guideline_summary_view.guideline_url; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.guideline_summary_view.guideline_url IS 'The URL of the guideline on the CPIC website';


--
-- Name: COLUMN guideline_summary_view.drugs; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.guideline_summary_view.drugs IS 'An array of drug names associated with this guideline';


--
-- Name: COLUMN guideline_summary_view.genes; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.guideline_summary_view.genes IS 'An array of gene data associated with this guideline, each object will have a symbol and a URL for the gene on the CPIC website';


--
-- Name: pair_view; Type: VIEW; Schema: cpic; Owner: -
--

CREATE VIEW cpic.pair_view AS
 SELECT p.pairid,
    p.drugid,
    d.name AS drugname,
    p.genesymbol,
    g.name AS guidelinename,
    g.url AS guidelineurl,
    p.cpiclevel,
    p.pgkbcalevel,
    p.pgxtesting,
    p.citations AS pmids,
        CASE
            WHEN (p.usedforrecommendation AND (p.guidelineid IS NOT NULL)) THEN 'Yes'::text
            WHEN ((NOT p.usedforrecommendation) AND (p.guidelineid IS NOT NULL)) THEN 'No'::text
            ELSE 'n/a'::text
        END AS usedforrecommendation,
        CASE
            WHEN (p.guidelineid IS NULL) THEN true
            ELSE false
        END AS provisional
   FROM ((cpic.pair p
     JOIN cpic.drug d ON (((p.drugid)::text = (d.drugid)::text)))
     LEFT JOIN cpic.guideline g ON ((p.guidelineid = g.id)))
  WHERE (p.removed IS FALSE);


--
-- Name: VIEW pair_view; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON VIEW cpic.pair_view IS 'This pairs view combines information from the pair, drug, and guideline tables to make a more readable view of pair data. This also limits result to pairs which have NOT been removed.';


--
-- Name: COLUMN pair_view.pairid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair_view.pairid IS 'The primary key ID of this pair';


--
-- Name: COLUMN pair_view.drugid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair_view.drugid IS 'The ID of the drug in the pair';


--
-- Name: COLUMN pair_view.drugname; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair_view.drugname IS 'The name of the drug in the pair';


--
-- Name: COLUMN pair_view.genesymbol; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair_view.genesymbol IS 'The symbol of the drug in the pair';


--
-- Name: COLUMN pair_view.guidelinename; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair_view.guidelinename IS 'The name for the guideline of this pair';


--
-- Name: COLUMN pair_view.guidelineurl; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair_view.guidelineurl IS 'The URL for the guideline of this pair';


--
-- Name: COLUMN pair_view.cpiclevel; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair_view.cpiclevel IS 'The CPIC-assigned level of the pair';


--
-- Name: COLUMN pair_view.pgkbcalevel; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair_view.pgkbcalevel IS 'The top level of PharmGKB Clinical Annotation of the pair';


--
-- Name: COLUMN pair_view.pgxtesting; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair_view.pgxtesting IS 'The testing level of the label annotation from PharmGKB for this pair';


--
-- Name: COLUMN pair_view.pmids; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair_view.pmids IS 'The PMIDs for guideline publications of this pair';


--
-- Name: COLUMN pair_view.provisional; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.pair_view.provisional IS 'The CPIC level assigned to this pair is provisional, true if this pair is not part of a guideline';


--
-- Name: population; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.population (
    id integer DEFAULT nextval('cpic.cpic_id'::regclass) NOT NULL,
    publicationid integer,
    ethnicity text NOT NULL,
    population text,
    populationinfo text,
    subjecttype text,
    subjectcount integer DEFAULT 0,
    version integer DEFAULT 1
);


--
-- Name: TABLE population; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.population IS 'A population description of a group of subjects';


--
-- Name: COLUMN population.id; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.population.id IS 'A synthetic primary key ID';


--
-- Name: COLUMN population.publicationid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.population.publicationid IS 'A reference to a publication';


--
-- Name: COLUMN population.ethnicity; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.population.ethnicity IS 'The major ethnicity grouping of this population';


--
-- Name: COLUMN population.population; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.population.population IS 'The descriptive name of this population, optional';


--
-- Name: COLUMN population.populationinfo; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.population.populationinfo IS 'Further information about this population, optional';


--
-- Name: COLUMN population.subjecttype; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.population.subjecttype IS 'Information about the types of subjects in this population';


--
-- Name: COLUMN population.subjectcount; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.population.subjectcount IS 'The total number of subjects in this population';


--
-- Name: COLUMN population.version; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.population.version IS 'The version number, iterates on modification';


--
-- Name: population_frequency_view; Type: VIEW; Schema: cpic; Owner: -
--

CREATE VIEW cpic.population_frequency_view AS
 WITH x AS (
         SELECT a.id AS alleleid,
            a.genesymbol,
            a.name,
            f.key AS population_group,
                CASE
                    WHEN (jsonb_typeof(f.value) = 'null'::text) THEN NULL::numeric
                    ELSE (f.value)::numeric
                END AS freq_weighted_avg
           FROM (cpic.allele a
             CROSS JOIN LATERAL jsonb_each(a.frequency) f(key, value))
        ), y AS (
         SELECT f.alleleid,
            p.ethnicity,
            max(f.frequency) AS freq_max,
            min(f.frequency) AS freq_min,
            avg(f.frequency) AS freq_avg,
            sum(p.subjectcount) AS subjectcount
           FROM (cpic.population p
             JOIN cpic.allele_frequency f ON ((p.id = f.population)))
          GROUP BY f.alleleid, p.ethnicity
        )
 SELECT x.genesymbol,
    x.name,
    x.population_group,
    y.subjectcount,
    x.freq_weighted_avg,
    y.freq_avg,
    y.freq_max,
    y.freq_min
   FROM (x
     JOIN y ON (((x.alleleid = y.alleleid) AND (x.population_group = y.ethnicity))));


--
-- Name: VIEW population_frequency_view; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON VIEW cpic.population_frequency_view IS 'A summary of frequency data by allele and major population group';


--
-- Name: COLUMN population_frequency_view.genesymbol; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.population_frequency_view.genesymbol IS 'The HGNC symbol of the gene';


--
-- Name: COLUMN population_frequency_view.name; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.population_frequency_view.name IS 'The allele name';


--
-- Name: COLUMN population_frequency_view.population_group; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.population_frequency_view.population_group IS 'The major grouping of population';


--
-- Name: COLUMN population_frequency_view.subjectcount; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.population_frequency_view.subjectcount IS 'The count of subjects assigned the population group for the given allele';


--
-- Name: COLUMN population_frequency_view.freq_weighted_avg; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.population_frequency_view.freq_weighted_avg IS 'The average frequency weighted by total subjects';


--
-- Name: COLUMN population_frequency_view.freq_avg; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.population_frequency_view.freq_avg IS 'The unweighted average frequency (use with caution)';


--
-- Name: COLUMN population_frequency_view.freq_max; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.population_frequency_view.freq_max IS 'The maximum frequency observed';


--
-- Name: COLUMN population_frequency_view.freq_min; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.population_frequency_view.freq_min IS 'The minimum frequency observed';


--
-- Name: publication; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.publication (
    id integer DEFAULT nextval('cpic.cpic_id'::regclass) NOT NULL,
    guidelineid integer,
    title text,
    authors text[],
    journal text,
    month integer,
    page character varying(50),
    volume character varying(50),
    year integer,
    pmid text,
    pmcid text,
    doi text,
    url text,
    version integer DEFAULT 1,
    highlightedonsite boolean DEFAULT false,
    fulltextfile text
);


--
-- Name: TABLE publication; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.publication IS 'Documents published to an external resource';


--
-- Name: COLUMN publication.id; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.publication.id IS 'A synthetic numerical ID, auto-assigned, primary key';


--
-- Name: COLUMN publication.guidelineid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.publication.guidelineid IS 'The ID for the guideline this publication is about, optional';


--
-- Name: COLUMN publication.pmid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.publication.pmid IS 'The PubMed identifier for this publication';


--
-- Name: COLUMN publication.pmcid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.publication.pmcid IS 'The PubMed Central identifier for this publication';


--
-- Name: COLUMN publication.doi; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.publication.doi IS 'The Document Object Identifier (DOI) for this publication';


--
-- Name: COLUMN publication.url; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.publication.url IS 'The URL for this publication';


--
-- Name: COLUMN publication.highlightedonsite; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.publication.highlightedonsite IS 'true means this publication will show in the CPIC site Publications page, defaults to false';


--
-- Name: COLUMN publication.fulltextfile; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.publication.fulltextfile IS 'publicly-accessible URL to full text of publication';


--
-- Name: publication_supplement; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.publication_supplement (
    id integer DEFAULT nextval('cpic.cpic_id'::regclass) NOT NULL,
    publicationid integer NOT NULL,
    description text,
    url text NOT NULL,
    version integer DEFAULT 1
);


--
-- Name: TABLE publication_supplement; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.publication_supplement IS 'A table to hold optional supplemental files for publications';


--
-- Name: COLUMN publication_supplement.id; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.publication_supplement.id IS 'A synthetic numerical ID, primary key';


--
-- Name: COLUMN publication_supplement.publicationid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.publication_supplement.publicationid IS 'A foreign-key reference to the publication this is a supplement for';


--
-- Name: COLUMN publication_supplement.description; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.publication_supplement.description IS 'An optional free text description of the supplemental file';


--
-- Name: COLUMN publication_supplement.url; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.publication_supplement.url IS 'The publicly-accessible URL to the supplemental file';


--
-- Name: COLUMN publication_supplement.version; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.publication_supplement.version IS 'The version number, iterates on modification';


--
-- Name: recommendation_alleles_view; Type: VIEW; Schema: cpic; Owner: -
--

CREATE VIEW cpic.recommendation_alleles_view AS
 SELECT a.genesymbol,
    g.chr,
    g.lookupmethod,
    array_agg(DISTINCT a.name ORDER BY a.name) AS alleles,
    count(DISTINCT a.name) AS allele_count
   FROM (cpic.allele a
     JOIN cpic.gene g ON (((a.genesymbol)::text = (g.symbol)::text)))
  WHERE ((a.clinicalfunctionalstatus IS NOT NULL) AND (g.lookupmethod <> 'ALLELE_STATUS'::text))
  GROUP BY a.genesymbol, g.chr, g.lookupmethod
UNION
 SELECT g.symbol AS genesymbol,
    g.chr,
    g.lookupmethod,
    array_agg(DISTINCT a.value ORDER BY a.value) AS alleles,
    count(DISTINCT a.value) AS allele_count
   FROM (cpic.recommendation r
     JOIN cpic.drug d ON (((r.drugid)::text = (d.drugid)::text))),
    (LATERAL jsonb_each_text(r.lookupkey) a(key, value)
     JOIN cpic.gene g ON ((a.key = (g.symbol)::text)))
  WHERE ((r.allelestatus IS NOT NULL) AND (g.lookupmethod = 'ALLELE_STATUS'::text) AND (upper(a.value) !~~ '%NO%RESULT%'::text))
  GROUP BY g.symbol, g.chr, g.lookupmethod;


--
-- Name: VIEW recommendation_alleles_view; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON VIEW cpic.recommendation_alleles_view IS 'A list of genes that are used for recommendation lookup and the alleles to use for those lookups';


--
-- Name: sequence_location; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.sequence_location (
    id integer DEFAULT nextval('cpic.cpic_id'::regclass) NOT NULL,
    version integer DEFAULT 1,
    name text,
    chromosomelocation text,
    genelocation text,
    proteinlocation text,
    genesymbol character varying(50) NOT NULL,
    dbsnpid text,
    "position" integer,
    CONSTRAINT chromosomelocation_nn CHECK ((chromosomelocation IS NOT NULL)),
    CONSTRAINT position_nn CHECK (("position" IS NOT NULL))
);


--
-- Name: TABLE sequence_location; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.sequence_location IS 'A location on a sequence';


--
-- Name: COLUMN sequence_location.name; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.sequence_location.name IS 'The short name of this sequence location, arbitrary but often the gene location and nucleotide change';


--
-- Name: COLUMN sequence_location.chromosomelocation; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.sequence_location.chromosomelocation IS 'The partial HGVS representation of the location on the chromosomal sequence';


--
-- Name: COLUMN sequence_location.genelocation; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.sequence_location.genelocation IS 'The partial HGVS representation of the location on the gene sequence';


--
-- Name: COLUMN sequence_location.proteinlocation; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.sequence_location.proteinlocation IS 'The partial HGVS representation of the location on the protein sequence';


--
-- Name: COLUMN sequence_location.genesymbol; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.sequence_location.genesymbol IS 'The HGNC symbol fo the gene this squence location falls in';


--
-- Name: COLUMN sequence_location.dbsnpid; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.sequence_location.dbsnpid IS 'The DBSNP identifier (rs#) for this location, optional';


--
-- Name: COLUMN sequence_location."position"; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.sequence_location."position" IS 'The position, or starting position, of this variation on the chromosomal/mitochondrial sequence';


--
-- Name: statistic; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.statistic (
    createdon timestamp without time zone NOT NULL,
    stattype text NOT NULL,
    statvalue numeric NOT NULL
);


--
-- Name: TABLE statistic; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.statistic IS 'A collection of numerical statistics with metadata about this database and other CPIC data';


--
-- Name: term; Type: TABLE; Schema: cpic; Owner: -
--

CREATE TABLE cpic.term (
    id integer DEFAULT nextval('cpic.cpic_id'::regclass) NOT NULL,
    category text NOT NULL,
    term text NOT NULL,
    functionaldef text,
    geneticdef text,
    loinc text,
    version integer DEFAULT 1
);


--
-- Name: TABLE term; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON TABLE cpic.term IS 'Standardized terms for clinical PGx test results';


--
-- Name: COLUMN term.id; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.term.id IS 'A synthetic numerical ID, auto-assigned, primary key';


--
-- Name: COLUMN term.category; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.term.category IS 'Category group this term falls into';


--
-- Name: COLUMN term.term; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.term.term IS 'The term name';


--
-- Name: COLUMN term.functionaldef; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.term.functionaldef IS 'The functional definition of the term';


--
-- Name: COLUMN term.geneticdef; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.term.geneticdef IS 'The genetic definition of the term';


--
-- Name: COLUMN term.loinc; Type: COMMENT; Schema: cpic; Owner: -
--

COMMENT ON COLUMN cpic.term.loinc IS 'The LOINC identifier for the term';




--
-- Data for Name: allele_definition; Type: TABLE DATA; Schema: cpic; Owner: -
--

COPY cpic.allele_definition (id, version, genesymbol, name, pharmvarid, matchesreferencesequence, structuralvariation) FROM stdin;
9000	1	HLA-A	*31:01	\N	f	f
9001	1	HLA-B	*15:02	\N	f	f
9002	1	HLA-B	*57:01	\N	f	f
9003	1	HLA-B	*58:01	\N	f	f
777464	165	CYP2B6	*23	PV00761	f	f
777466	165	CYP2B6	*24	PV00762	f	f
6355215	3	CFTR	A234D	\N	f	f
1406321	135	CYP2C9	*75	PV01742	f	f
777704	165	CYP2C9	*19	PV00555	f	f
777958	165	CYP2D6	*12	PV00437	f	f
777474	165	CYP2B6	*28	PV00766	f	f
777476	160	CYP2B6	*29	PV00767	f	t
777478	160	CYP2B6	*30	PV00770	f	t
777480	165	CYP2B6	*31	PV00771	f	f
777482	165	CYP2B6	*32	PV00772	f	f
777484	165	CYP2B6	*33	PV00848	f	f
777486	165	CYP2B6	*34	PV00774	f	f
777490	165	CYP2B6	*36	PV00776	f	f
777492	165	CYP2B6	*37	PV00777	f	f
777494	165	CYP2B6	*38	PV00778	f	f
2899154	79	CYP2B6	*45	PV02278	f	f
2899156	79	CYP2B6	*46	PV02280	f	f
2899158	79	CYP2B6	*47	PV02282	f	f
2899162	79	CYP2B6	*49	PV02286	f	f
5997308	12	CYP2B6	*50	PV02841	f	f
777432	165	CYP2B6	*6	PV00744	f	f
777434	165	CYP2B6	*7	PV00745	f	f
777436	165	CYP2B6	*8	PV00746	f	f
777438	165	CYP2B6	*9	PV00747	f	f
777580	165	CYP2C19	*28	PV00622	f	f
777578	165	CYP2C19	*26	PV00621	f	f
6235065	8	CYP2C19	*41	PV02896	f	f
777592	165	CYP2C19	*34	PV02143	f	f
777690	165	CYP2C9	*12	PV00548	f	f
777442	165	CYP2B6	*11	PV00749	f	f
777716	165	CYP2C9	*25	PV00561	f	f
777732	165	CYP2C9	*33	PV00569	f	f
777794	165	CYP2C9	*64	PV01419	f	f
778180	165	CYP2D6	*131	PV00686	f	f
777746	165	CYP2C9	*40	PV00576	f	f
778182	165	CYP2D6	*132	PV00687	f	f
778188	165	CYP2D6	*135	PV00690	f	f
778190	165	CYP2D6	*136	PV00691	f	f
777766	165	CYP2C9	*50	PV00586	f	f
778192	165	CYP2D6	*137	PV00692	f	f
777776	165	CYP2C9	*55	PV00591	f	f
777454	165	CYP2B6	*18	PV00756	f	f
778196	165	CYP2D6	*139	PV00728	f	f
777678	165	CYP2C9	*6	PV00542	f	f
778200	165	CYP2D6	*141	PV02389	f	f
778202	165	CYP2D6	*142	PV01434	f	f
778206	165	CYP2D6	*144	PV01436	f	f
778208	165	CYP2D6	*145	PV01437	f	f
6355245	3	CFTR	F311del	\N	f	f
1103377	147	CYP2D6	*146	PV01717	f	f
1609527	128	CYP2D6	*148	PV01745	f	f
1103381	147	CYP2D6	*149	PV01730	f	f
2677013	87	CYP2D6	*151	PV02194	f	f
2091236	109	CYP2D6	*152	PV02155	f	f
2091242	109	CYP2D6	*155	PV01936	f	f
2091244	109	CYP2D6	*156	PV01943	f	f
2091246	109	CYP2D6	*157	PV01947	f	f
777440	165	CYP2B6	*10	PV00748	f	f
777444	165	CYP2B6	*12	PV00750	f	f
777448	165	CYP2B6	*14	PV00752	f	f
777468	165	CYP2B6	*25	PV00763	f	f
777680	165	CYP2C9	*7	PV00543	f	f
778178	165	CYP2D6	*130	PV00685	f	f
777450	165	CYP2B6	*15	PV00753	f	f
777452	165	CYP2B6	*17	PV00755	f	f
6355213	3	CFTR	A120T	\N	f	f
777456	165	CYP2B6	*19	PV00757	f	f
6355217	3	CFTR	A349V	\N	f	f
6355227	3	CFTR	D192G	\N	f	f
6355231	3	CFTR	D924N	\N	f	f
777333	93	CFTR	E56K	\N	f	f
6355241	3	CFTR	E822K	\N	f	f
6355327	3	CFTR	Q237H	\N	f	f
777470	165	CYP2B6	*26	PV00764	f	f
1933003	115	CYP2C9	*85	PV01798	f	f
778184	165	CYP2D6	*133	PV00688	f	f
6355247	3	CFTR	F311L	\N	f	f
6355249	3	CFTR	F508C	\N	f	f
6355257	3	CFTR	G178E	\N	f	f
6355261	3	CFTR	G194R(G>A)	\N	f	f
6355263	3	CFTR	G194R(G>C)	\N	f	f
6355265	3	CFTR	G314E	\N	f	f
1103379	147	CYP2D6	*147	PV01805	f	f
6355271	3	CFTR	G576A	\N	f	f
6355273	3	CFTR	G970D	\N	f	f
6355279	3	CFTR	G1249R(G>A)	\N	f	f
6355281	3	CFTR	G1249R(G>C)	\N	f	f
6355285	3	CFTR	H939R	\N	f	f
6355287	3	CFTR	H1375P	\N	f	f
6355289	3	CFTR	I148T	\N	f	f
6355293	3	CFTR	I807M	\N	f	f
6355295	3	CFTR	I1027T	\N	f	f
6355297	3	CFTR	I1139V	\N	f	f
6355303	3	CFTR	L320V	\N	f	f
6355305	3	CFTR	L967S	\N	f	f
6355307	3	CFTR	L997F(G>C)	\N	f	f
6355309	3	CFTR	L997F(G>T)	\N	f	f
6355311	3	CFTR	L1480P	\N	f	f
6355313	3	CFTR	M152V	\N	f	f
6355315	3	CFTR	M952I(G>A)	\N	f	f
6355319	3	CFTR	M952I(G>T)	\N	f	f
6355321	3	CFTR	M952T	\N	f	f
777357	93	CFTR	P67L	\N	f	f
6355325	3	CFTR	Q237E	\N	f	f
6355329	3	CFTR	Q359R	\N	f	f
6355331	3	CFTR	Q1291R	\N	f	f
6355335	3	CFTR	R75Q	\N	f	f
6355339	3	CFTR	R117G	\N	f	f
6355343	3	CFTR	R117L	\N	f	f
6355345	3	CFTR	R117P	\N	f	f
6355347	3	CFTR	R170H	\N	f	f
6355351	3	CFTR	R347L	\N	f	f
6355355	3	CFTR	R553Q	\N	f	f
6355357	3	CFTR	R668C	\N	f	f
6355359	3	CFTR	R792G	\N	f	f
6355361	3	CFTR	R933G	\N	f	f
777460	165	CYP2B6	*21	PV00759	f	f
777462	165	CYP2B6	*22	PV00760	f	f
2091238	109	CYP2D6	*153	PV02157	f	f
778054	160	CYP2D6	*61	PV00485	f	t
779307	158	SLCO1B1	*16	PV01633	f	f
5175554	26	CYP2D6	*175	PV02502	f	f
779321	158	SLCO1B1	*23	PV01636	f	f
778052	165	CYP2D6	*60	PV00484	f	f
2677053	87	CYP2D6	*171	PV02189	f	f
5175550	26	CYP2D6	*173	PV02498	f	f
5409119	22	CYP2D6	*176	PV02519	f	f
5763832	16	CYP2D6	*177	PV02522	f	f
5998158	12	CYP2D6	*178	PV02809	f	f
5998160	12	CYP2D6	*179	PV02811	f	f
779337	158	SLCO1B1	*31	PV01644	f	f
5998162	12	CYP2D6	*180	PV02813	f	f
5998164	12	CYP2D6	*181	PV02815	f	f
778080	165	CYP2D6	*81	PV00498	f	f
778114	165	CYP2D6	*98	PV00515	f	f
778112	165	CYP2D6	*97	PV00514	f	f
779297	158	SLCO1B1	*11	PV01628	f	f
778032	165	CYP2D6	*50	PV00474	f	f
778034	165	CYP2D6	*51	PV00475	f	f
778036	165	CYP2D6	*52	PV00476	f	f
778038	165	CYP2D6	*53	PV00477	f	f
778040	165	CYP2D6	*54	PV00478	f	f
778042	165	CYP2D6	*55	PV00479	f	f
778044	165	CYP2D6	*56	PV00480	f	f
778048	165	CYP2D6	*58	PV00482	f	f
778064	160	CYP2D6	*68	PV00490	f	t
778050	165	CYP2D6	*59	PV00483	f	f
777946	165	CYP2D6	*6	PV00431	f	f
777948	165	CYP2D6	*7	PV00432	f	f
778068	165	CYP2D6	*70	PV00492	f	f
778058	160	CYP2D6	*63	PV00487	f	t
778072	165	CYP2D6	*72	PV00494	f	f
778062	165	CYP2D6	*65	PV00489	f	f
778076	165	CYP2D6	*74	PV00496	f	f
778066	165	CYP2D6	*69	PV00491	f	f
777950	165	CYP2D6	*8	PV00433	f	f
778070	165	CYP2D6	*71	PV00493	f	f
778108	165	CYP2D6	*95	PV00512	f	f
778074	165	CYP2D6	*73	PV00495	f	f
778084	165	CYP2D6	*83	PV02385	f	f
778078	165	CYP2D6	*75	PV00497	f	f
778088	165	CYP2D6	*85	PV00502	f	f
778082	165	CYP2D6	*82	PV00499	f	f
778092	165	CYP2D6	*87	PV00504	f	f
778086	165	CYP2D6	*84	PV00501	f	f
778096	165	CYP2D6	*89	PV00506	f	f
778090	165	CYP2D6	*86	PV00503	f	f
2091250	109	CYP2D6	*159	PV01954	f	f
778094	165	CYP2D6	*88	PV00505	f	f
2091256	109	CYP2D6	*162	PV01967	f	f
777952	165	CYP2D6	*9	PV00434	f	f
4058604	41	CYP4F2	*17	PV02391	f	f
777978	165	CYP2D6	*23	PV00447	f	f
3318593	64	CYP4F2	*12	PV02322	f	f
778014	165	CYP2D6	*41	PV00465	f	f
3318599	64	CYP4F2	*15	PV02328	f	f
778018	165	CYP2D6	*43	PV00467	f	f
778240	164	CYP4F2	*2	PV02213	f	f
778022	165	CYP2D6	*45	PV00469	f	f
2677049	87	CYP2D6	*169	PV02163	f	f
778028	165	CYP2D6	*48	PV00472	f	f
5998166	12	CYP2D6	*182	PV02817	f	f
779303	158	SLCO1B1	*14	PV01631	f	f
5998168	12	CYP2D6	*183	PV02819	f	f
1002697	149	SLCO1B1	*43	PV01655	f	f
3318587	64	CYP4F2	*9	PV02316	f	f
5998170	12	CYP2D6	*184	PV02821	f	f
5998172	12	CYP2D6	*185	PV02823	f	f
777970	165	CYP2D6	*19	PV02196	f	f
777988	165	CYP2D6	*28	PV00452	f	f
2784572	83	CYP4F2	*4	PV02221	f	f
778016	165	CYP2D6	*42	PV02297	f	f
778020	165	CYP2D6	*44	PV00468	f	f
2784578	83	CYP4F2	*7	PV02227	f	f
778024	165	CYP2D6	*46	PV00470	f	f
779080	164	NUDT15	*9	PV01605	f	f
778026	165	CYP2D6	*47	PV00471	f	f
778030	165	CYP2D6	*49	PV00473	f	f
778056	165	CYP2D6	*62	PV00486	f	f
778060	165	CYP2D6	*64	PV00488	f	f
3318595	64	CYP4F2	*13	PV02324	f	f
2784576	83	CYP4F2	*6	PV02225	f	f
3318585	64	CYP4F2	*8	PV02314	f	f
1002687	149	SLCO1B1	*38	PV01650	f	f
779335	158	SLCO1B1	*30	PV01643	f	f
6235063	8	CYP2C19	*40	PV02894	f	f
3318601	64	CYP4F2	*16	PV02312	f	t
779323	158	SLCO1B1	*24	PV01637	f	f
779327	158	SLCO1B1	*26	PV01639	f	f
779331	158	SLCO1B1	*28	PV01641	f	f
777758	165	CYP2C9	*46	PV00582	f	f
779281	158	SLCO1B1	*3	PV01620	f	f
779339	158	SLCO1B1	*32	PV01645	f	f
1002689	149	SLCO1B1	*39	PV01651	f	f
779299	158	SLCO1B1	*12	PV01629	f	f
779283	158	SLCO1B1	*4	PV01621	f	f
1002695	149	SLCO1B1	*42	PV01654	f	f
779305	158	SLCO1B1	*15	PV01632	f	f
1002703	149	SLCO1B1	*46	PV01658	f	f
779301	158	SLCO1B1	*13	PV01630	f	f
779315	158	SLCO1B1	*20	PV01635	f	f
779325	158	SLCO1B1	*25	PV01638	f	f
777682	165	CYP2C9	*8	PV00544	f	f
6235320	8	CYP2C9	*86	PV02929	f	f
2091258	109	CYP2D6	*163	PV01969	f	f
6235324	8	CYP2C9	*88	PV02933	f	f
778186	165	CYP2D6	*134	PV00689	f	f
778204	165	CYP2D6	*143	PV01435	f	f
2677011	87	CYP2D6	*150	PV02524	f	f
6355367	3	CFTR	R1162L	\N	f	f
6235322	8	CYP2C9	*87	PV02931	f	f
2091252	109	CYP2D6	*160	PV01958	f	f
2091254	109	CYP2D6	*161	PV01963	f	f
2677039	87	CYP2D6	*164	PV02199	f	f
2677043	87	CYP2D6	*166	PV02203	f	f
779343	158	SLCO1B1	*34	PV01647	f	f
2677051	87	CYP2D6	*170	PV02165	f	f
2677045	87	CYP2D6	*167	PV02159	f	f
3318539	64	CYP2D6	*172	PV02301	f	f
2677047	87	CYP2D6	*168	PV02161	f	f
5175552	26	CYP2D6	*174	PV02500	f	f
779347	158	SLCO1B1	*36	PV01648	f	f
1002693	149	SLCO1B1	*41	PV01653	f	f
1357091	137	SLCO1B1	*48	PV01732	f	t
777532	165	CYP2C19	*1	PV00598	f	f
779236	93	RYR1	c.14497C>T	\N	f	f
3685930	32	RYR1	c.14510delA	\N	f	f
3685976	32	RYR1	c.14918C>T	\N	f	f
3685978	32	RYR1	c.14968A>G	\N	f	f
779289	158	SLCO1B1	*7	PV01624	f	f
777550	165	CYP2C19	*10	PV00607	f	f
777544	165	CYP2C19	*7	PV02134	f	f
777548	165	CYP2C19	*9	PV00606	f	f
778242	164	CYP4F2	*3	PV02214	f	f
1002623	149	SLCO1B1	*1	PV01618	t	f
778435	93	DPYD	c.1905C>G	\N	f	f
778453	93	DPYD	c.2279C>T	\N	f	f
777944	160	CYP2D6	*5	PV00430	f	t
778485	93	DPYD	c.2983G>T (*10)	\N	f	f
778780	95	G6PD	Taipei, Chinese-3	\N	f	f
778872	93	G6PD	West Virginia	\N	f	f
779041	93	IFNL3	rs12979860 reference (C)	\N	t	f
3685876	32	RYR1	c.13672C>T	\N	f	f
779291	158	SLCO1B1	*8	PV01625	f	f
3685878	32	RYR1	c.13702C>G	\N	f	f
3685890	32	RYR1	c.13994_13995delTCinsCT	\N	f	f
3685892	32	RYR1	c.14002C>T	\N	f	f
3685894	32	RYR1	c.14051T>C	\N	f	f
3685896	32	RYR1	c.14126C>T	\N	f	f
3685902	32	RYR1	c.14197T>G	\N	f	f
3685904	32	RYR1	c.14201G>A	\N	f	f
3685916	32	RYR1	c.14424C>A	\N	f	f
777552	165	CYP2C19	*11	PV00608	f	f
3685918	32	RYR1	c.14449A>T	\N	f	f
779293	158	SLCO1B1	*9	PV01626	f	f
777554	165	CYP2C19	*12	PV00609	f	f
777572	165	CYP2C19	*23	PV00618	f	f
777574	165	CYP2C19	*24	PV00619	f	f
777576	165	CYP2C19	*25	PV00620	f	f
3685898	32	RYR1	c.14168G>A	\N	f	f
779279	158	SLCO1B1	*2	PV01619	f	f
777562	165	CYP2C19	*16	PV02139	f	f
777564	165	CYP2C19	*17	PV00614	f	f
778954	93	G6PD	Puerto Limon	\N	f	f
779043	93	IFNL3	rs12979860 variant (T)	\N	f	f
3685874	32	RYR1	c.13673G>A	\N	f	f
3685880	32	RYR1	c.13760C>T	\N	f	f
3685920	32	RYR1	c.14458G>A	\N	f	f
3685922	32	RYR1	c.14458G>T	\N	f	f
777598	160	CYP2C19	*37	PV00732	f	t
3685924	32	RYR1	c.14471T>C	\N	f	f
779234	93	RYR1	c.14477C>T	\N	f	f
3685932	32	RYR1	c.14509C>G	\N	f	f
779238	93	RYR1	c.14512C>G	\N	f	f
3685936	32	RYR1	c.14524G>A	\N	f	f
779240	93	RYR1	c.14545G>A	\N	f	f
3685942	32	RYR1	c.14558C>T	\N	f	f
3685944	32	RYR1	c.14567C>G	\N	f	f
779242	93	RYR1	c.14582G>A	\N	f	f
3685948	32	RYR1	c.14581C>T	\N	f	f
3685950	32	RYR1	c.14627A>G	\N	f	f
3685952	32	RYR1	c.14639T>C	\N	f	f
3685954	32	RYR1	c.14678G>A	\N	f	f
3685956	32	RYR1	c.14680G>A	\N	f	f
779244	93	RYR1	c.14693T>C	\N	f	f
777566	165	CYP2C19	*18	PV00615	f	f
3685960	32	RYR1	c.14782A>G	\N	f	f
3685962	32	RYR1	c.14803G>A	\N	f	f
3685964	32	RYR1	c.14813T>C	\N	f	f
3685966	32	RYR1	c.14814C>G	\N	f	f
3685968	32	RYR1	c.14817C>A	\N	f	f
3685970	32	RYR1	c.14818G>A	\N	f	f
3685980	32	RYR1	c.15059G>C	\N	f	f
779333	158	SLCO1B1	*29	PV01642	f	f
1002685	149	SLCO1B1	*37	PV01649	f	f
1357093	137	SLCO1B1	*49	PV01734	f	t
779285	158	SLCO1B1	*5	PV01622	f	f
777556	165	CYP2C19	*13	PV00610	f	f
777558	165	CYP2C19	*14	PV00611	f	f
6355369	3	CFTR	R1283M	\N	f	f
777560	165	CYP2C19	*15	PV00612	f	f
6355377	3	CFTR	S589N	\N	f	f
6355379	3	CFTR	S737F	\N	f	f
777568	165	CYP2C19	*19	PV00616	f	f
777534	165	CYP2C19	*2	PV00599	f	f
6355385	3	CFTR	S1159F	\N	f	f
6355387	3	CFTR	S1159P	\N	f	f
6355393	3	CFTR	T338I	\N	f	f
6355395	3	CFTR	T1053I	\N	f	f
778990	93	G6PD	Santiago de Cuba, Morioka	\N	f	f
6355397	3	CFTR	V232D	\N	f	f
6355399	3	CFTR	V562I	\N	f	f
3685972	32	RYR1	c.14825G>T	\N	f	f
3685974	32	RYR1	c.14879T>A	\N	f	f
778116	165	CYP2D6	*99	PV00516	f	f
6355401	3	CFTR	V754M	\N	f	f
3685900	32	RYR1	c.14186A>C	\N	f	f
3685906	32	RYR1	c.14209C>T	\N	f	f
3685908	32	RYR1	c.14210G>A	\N	f	f
3685910	32	RYR1	c.14270G>A	\N	f	f
779232	93	RYR1	c.14387A>G	\N	f	f
6355403	3	CFTR	V1293G	\N	f	f
3685938	32	RYR1	c.14539G>C	\N	f	f
1002701	149	SLCO1B1	*45	PV01657	f	f
6355405	3	CFTR	W1282R	\N	f	f
6355407	3	CFTR	Y1014C	\N	f	f
6355409	3	CFTR	Y1032C	\N	f	f
777536	165	CYP2C19	*3	PV00600	f	f
777600	165	CYP2C19	*39	PV01528	f	f
777570	165	CYP2C19	*22	PV00617	f	f
3685882	32	RYR1	c.13913G>A	\N	f	f
779287	158	SLCO1B1	*6	PV01623	f	f
777538	165	CYP2C19	*4	PV00601	f	f
777594	165	CYP2C19	*35	PV00629	f	f
3685886	32	RYR1	c.13934G>A	\N	f	f
3685888	32	RYR1	c.13990T>C	\N	f	f
777540	165	CYP2C19	*5	PV02131	f	f
777542	165	CYP2C19	*6	PV00603	f	f
778337	93	DPYD	c.295_298delTCAT (*7)	\N	f	f
777804	165	CYP2C9	*69	PV01424	f	f
777806	165	CYP2C9	*70	PV01425	f	f
1406315	135	CYP2C9	*72	PV01736	f	f
1406317	135	CYP2C9	*73	PV01738	f	f
1406319	135	CYP2C9	*74	PV01803	f	f
1932985	115	CYP2C9	*76	PV01780	f	f
1932987	115	CYP2C9	*77	PV01782	f	f
778712	93	G6PD	A- 202A_376G	\N	f	f
778742	93	G6PD	Acrokorinthos	\N	f	f
779002	93	G6PD	Andalus	\N	f	f
778826	93	G6PD	Asahikawa	\N	f	f
778938	93	G6PD	Beverly Hills, Genova, Iwate, Niigata, Yamaguchi	\N	f	f
1932989	115	CYP2C9	*78	PV01784	f	f
777726	165	CYP2C9	*30	PV00566	f	f
777728	165	CYP2C9	*31	PV00567	f	f
777730	165	CYP2C9	*32	PV00568	f	f
777734	165	CYP2C9	*34	PV00570	f	f
777738	165	CYP2C9	*36	PV00572	f	f
1932991	115	CYP2C9	*79	PV01786	f	f
1932993	115	CYP2C9	*80	PV01788	f	f
1932997	115	CYP2C9	*82	PV01792	f	f
779038	93	G6PD	Brighton	\N	f	f
777740	165	CYP2C9	*37	PV00573	f	f
778774	93	G6PD	Gond	\N	f	f
778906	93	G6PD	Ierapetra	\N	f	f
778724	93	G6PD	Lagosanto	\N	f	f
778800	94	G6PD	Mediterranean, Dallas, Panama, Sassari, Cagliari, Birmingham	\N	f	f
777742	165	CYP2C9	*38	PV00574	f	f
777744	165	CYP2C9	*39	PV00575	f	f
778802	93	G6PD	Pedoplis-Ckaro	\N	f	f
777748	165	CYP2C9	*41	PV00577	f	f
777750	165	CYP2C9	*42	PV00578	f	f
777752	165	CYP2C9	*43	PV00579	f	f
777756	165	CYP2C9	*45	PV00581	f	f
778744	93	G6PD	Santa Maria	\N	f	f
777760	165	CYP2C9	*47	PV00583	f	f
777762	165	CYP2C9	*48	PV00584	f	f
777764	165	CYP2C9	*49	PV00585	f	f
777676	165	CYP2C9	*5	PV00541	f	f
777768	165	CYP2C9	*51	PV00587	f	f
3685694	32	RYR1	c.7771C>T	\N	f	f
3685726	32	RYR1	c.8518C>T	\N	f	f
3685758	32	RYR1	c.9758T>C	\N	f	f
3685790	32	RYR1	c.10891G>T	\N	f	f
3685822	32	RYR1	c.11953T>C	\N	f	f
1932999	115	CYP2C9	*83	PV01794	f	f
1933001	115	CYP2C9	*84	PV01796	f	f
777770	165	CYP2C9	*52	PV00588	f	f
3685856	32	RYR1	c.12553G>A	\N	f	f
777428	165	CYP2B6	*4	PV00742	f	f
6355291	3	CFTR	I175V	\N	f	f
6355317	3	CFTR	M952I(G>C)	\N	f	f
777772	165	CYP2C9	*53	PV00589	f	f
777774	165	CYP2C9	*54	PV00590	f	f
777778	165	CYP2C9	*56	PV00592	f	f
777780	165	CYP2C9	*57	PV00593	f	f
777782	165	CYP2C9	*58	PV00594	f	f
777684	165	CYP2C9	*9	PV00545	f	f
777784	165	CYP2C9	*59	PV00595	f	f
777786	165	CYP2C9	*60	PV00596	f	f
777788	165	CYP2C9	*61	PV00597	f	f
777994	165	CYP2D6	*31	PV00455	f	f
6235905	8	CYP4F2	*18	PV02945	f	f
6235907	8	CYP4F2	*19	PV02947	f	f
777790	165	CYP2C9	*62	PV00851	f	f
777686	165	CYP2C9	*10	PV00546	f	f
777692	165	CYP2C9	*13	PV00549	f	f
777694	165	CYP2C9	*14	PV00550	f	f
777698	165	CYP2C9	*16	PV00552	f	f
777700	165	CYP2C9	*17	PV00553	f	f
777702	165	CYP2C9	*18	PV00554	f	f
777792	165	CYP2C9	*63	PV01418	f	f
777796	165	CYP2C9	*65	PV01420	f	f
6235909	8	CYP4F2	*20	PV02949	f	f
6235911	8	CYP4F2	*21	PV02951	f	f
777798	165	CYP2C9	*66	PV01421	f	f
6235913	8	CYP4F2	*22	PV02953	f	f
6235915	8	CYP4F2	*23	PV02955	f	f
777800	165	CYP2C9	*67	PV01422	f	f
777670	165	CYP2C9	*2	PV00538	f	f
777706	165	CYP2C9	*20	PV00556	f	f
777712	165	CYP2C9	*23	PV00559	f	f
777714	165	CYP2C9	*24	PV00560	f	f
777720	165	CYP2C9	*27	PV00563	f	f
777722	165	CYP2C9	*28	PV00564	f	f
778483	93	DPYD	c.2977C>T	\N	f	f
777724	165	CYP2C9	*29	PV00565	f	f
777672	165	CYP2C9	*3	PV00539	f	f
777802	165	CYP2C9	*68	PV01423	f	f
778714	93	G6PD	202G>A_376A>G_1264C>G	\N	f	f
778752	93	G6PD	A	\N	f	f
777472	165	CYP2B6	*27	PV00765	f	f
2899142	79	CYP2B6	*39	PV02266	f	f
2899146	79	CYP2B6	*41	PV02270	f	f
2899148	79	CYP2B6	*42	PV02272	f	f
2899150	79	CYP2B6	*43	PV02274	f	f
2899152	79	CYP2B6	*44	PV02276	f	f
777430	165	CYP2B6	*5	PV00743	f	f
777530	165	CYP2C19	*38	PV02145	t	f
777936	165	CYP2D6	*1	PV00426	t	f
777954	165	CYP2D6	*10	PV00435	f	f
778118	165	CYP2D6	*100	PV00517	f	f
778120	165	CYP2D6	*101	PV00518	f	f
778122	165	CYP2D6	*102	PV00519	f	f
778124	165	CYP2D6	*103	PV00520	f	f
778126	165	CYP2D6	*104	PV00521	f	f
778128	165	CYP2D6	*105	PV00522	f	f
778130	165	CYP2D6	*106	PV00523	f	f
778132	165	CYP2D6	*107	PV00524	f	f
778136	165	CYP2D6	*109	PV00526	f	f
777956	165	CYP2D6	*11	PV00436	f	f
778138	165	CYP2D6	*110	PV00527	f	f
778140	165	CYP2D6	*111	PV00528	f	f
778142	165	CYP2D6	*112	PV00529	f	f
778144	165	CYP2D6	*113	PV00530	f	f
777962	165	CYP2D6	*14	PV00439	f	f
777964	165	CYP2D6	*15	PV00440	f	f
777966	165	CYP2D6	*17	PV00441	f	f
777968	165	CYP2D6	*18	PV01591	f	f
777938	165	CYP2D6	*2	PV00427	f	f
777972	165	CYP2D6	*20	PV01749	f	f
777974	165	CYP2D6	*21	PV02825	f	f
777976	165	CYP2D6	*22	PV00446	f	f
777980	165	CYP2D6	*24	PV00448	f	f
777982	165	CYP2D6	*25	PV00449	f	f
777984	165	CYP2D6	*26	PV00450	f	f
777986	165	CYP2D6	*27	PV00451	f	f
777990	165	CYP2D6	*29	PV00453	f	f
777940	165	CYP2D6	*3	PV00428	f	f
777992	165	CYP2D6	*30	PV00454	f	f
777996	165	CYP2D6	*32	PV00456	f	f
777998	165	CYP2D6	*33	PV00457	f	f
778000	165	CYP2D6	*34	PV00458	f	f
778002	165	CYP2D6	*35	PV00459	f	f
778004	165	CYP2D6	*36	PV02379	f	f
778006	165	CYP2D6	*37	PV00461	f	f
778008	165	CYP2D6	*38	PV01592	f	f
778010	165	CYP2D6	*39	PV00463	f	f
777942	165	CYP2D6	*4	PV00429	f	f
778012	165	CYP2D6	*40	PV00464	f	f
6237969	8	SLCO1B1	*50	PV02969	f	f
6237971	8	SLCO1B1	*51	PV02971	f	f
6237973	8	SLCO1B1	*52	PV02973	f	f
6237975	8	SLCO1B1	*53	PV02975	f	f
6237977	8	SLCO1B1	*54	PV02977	f	f
3827906	26	MT-RNR1	m.1189T>C	\N	f	f
3827908	26	MT-RNR1	m.1243T>C	\N	f	f
3827910	26	MT-RNR1	m.1494C>T	\N	f	f
3827912	26	MT-RNR1	m.1520T>C	\N	f	f
3827914	26	MT-RNR1	m.1537C>T	\N	f	f
3827916	26	MT-RNR1	m.1555A>G	\N	f	f
3827918	26	MT-RNR1	m.1556C>T	\N	f	f
6481200	4	NAT2	*10	PV02400	f	f
779398	93	TPMT	*3B	\N	f	f
779400	93	TPMT	*3C	\N	f	f
779402	93	TPMT	*4	\N	f	f
779404	93	TPMT	*5	\N	f	f
779406	93	TPMT	*6	\N	f	f
779408	93	TPMT	*7	\N	f	f
779410	93	TPMT	*8	\N	f	f
779412	93	TPMT	*9	\N	f	f
779414	93	TPMT	*10	\N	f	f
779416	93	TPMT	*11	\N	f	f
779418	93	TPMT	*12	\N	f	f
779420	93	TPMT	*13	\N	f	f
779422	93	TPMT	*14	\N	f	f
779424	93	TPMT	*15	\N	f	f
779426	93	TPMT	*16	\N	f	f
779428	93	TPMT	*17	\N	f	f
779430	93	TPMT	*18	\N	f	f
779432	93	TPMT	*19	\N	f	f
779434	93	TPMT	*20	\N	f	f
779436	93	TPMT	*21	\N	f	f
778152	165	CYP2D6	*117	PV00534	f	f
778156	165	CYP2D6	*119	PV00536	f	f
1002691	149	SLCO1B1	*40	PV01652	f	f
1002705	149	SLCO1B1	*47	PV01659	f	f
779392	93	TPMT	*1	\N	t	f
777262	93	CACNA1S	Reference	\N	t	f
779394	93	TPMT	*2	\N	f	f
777266	93	CACNA1S	c.3257G>A	\N	f	f
777339	93	CFTR	F1074L	\N	f	f
777379	93	CFTR	S549R(A>C)	\N	f	f
777458	165	CYP2B6	*20	PV00758	f	f
779438	93	TPMT	*22	\N	f	f
779440	93	TPMT	*23	\N	f	f
779442	93	TPMT	*24	\N	f	f
779444	93	TPMT	*25	\N	f	f
777446	165	CYP2B6	*13	PV00751	f	f
777488	165	CYP2B6	*35	PV00775	f	f
778162	165	CYP2D6	*122	PV00632	f	f
778164	165	CYP2D6	*123	PV00633	f	f
778166	165	CYP2D6	*124	PV00634	f	f
778168	165	CYP2D6	*125	PV00681	f	f
778170	165	CYP2D6	*126	PV00682	f	f
777546	165	CYP2C19	*8	PV02136	f	f
778172	165	CYP2D6	*127	PV00635	f	f
777688	165	CYP2C9	*11	PV00547	f	f
778146	165	CYP2D6	*114	PV00531	f	f
777696	165	CYP2C9	*15	PV00551	f	f
777710	165	CYP2C9	*22	PV00558	f	f
778150	165	CYP2D6	*116	PV00533	f	f
777674	165	CYP2C9	*4	PV00540	f	f
3318597	64	CYP4F2	*14	PV02326	f	f
778176	165	CYP2D6	*129	PV00684	f	f
778148	165	CYP2D6	*115	PV00532	f	f
778098	165	CYP2D6	*90	PV00507	f	f
828095	92	MT-RNR1	Reference	\N	t	f
6481190	4	NAT2	*1	PV02395	t	f
2784574	83	CYP4F2	*5	PV02223	f	f
3827872	26	MT-RNR1	m.663A>G	\N	f	f
6481236	4	NAT2	*40	PV02418	f	f
6481206	4	NAT2	*16	PV02403	f	f
6481208	4	NAT2	*19	PV02404	f	f
3827874	26	MT-RNR1	m.669T>C	\N	f	f
3827876	26	MT-RNR1	m.747A>G	\N	f	f
3827878	26	MT-RNR1	m.786G>A	\N	f	f
3827880	26	MT-RNR1	m.807A>C	\N	f	f
3827882	26	MT-RNR1	m.807A>G	\N	f	f
3827884	26	MT-RNR1	m.827A>G	\N	f	f
3827886	26	MT-RNR1	m.839A>G	\N	f	f
779341	158	SLCO1B1	*33	PV01646	f	f
779396	93	TPMT	*3A	\N	f	f
3827888	26	MT-RNR1	m.896A>G	\N	f	f
3827890	26	MT-RNR1	m.930A>G	\N	f	f
3827892	26	MT-RNR1	m.951G>A	\N	f	f
3827894	26	MT-RNR1	m.960C>del	\N	f	f
3827896	26	MT-RNR1	m.961T>G	\N	f	f
3827898	26	MT-RNR1	m.961T>del	\N	f	f
3827900	26	MT-RNR1	m.961T>del+Cn	\N	f	f
3827902	26	MT-RNR1	m.988G>A	\N	f	f
3827904	26	MT-RNR1	m.1095T>C	\N	f	f
6481256	4	NAT2	*50	PV02428	f	f
6481210	4	NAT2	*21	PV02405	f	f
6481212	4	NAT2	*27	PV02406	f	f
6481216	4	NAT2	*30	PV02408	f	f
6481218	4	NAT2	*31	PV02409	f	f
6481220	4	NAT2	*32	PV02410	f	f
6481222	4	NAT2	*33	PV02411	f	f
6481226	4	NAT2	*35	PV02413	f	f
6481228	4	NAT2	*36	PV02414	f	f
6481230	4	NAT2	*37	PV02415	f	f
6481232	4	NAT2	*38	PV02416	f	f
6481192	4	NAT2	*4	PV02396	f	f
6481238	4	NAT2	*41	PV02419	f	f
6481276	4	NAT2	*60	PV02791	f	f
6481240	4	NAT2	*42	PV02420	f	f
6481244	4	NAT2	*44	PV02422	f	f
6481246	4	NAT2	*45	PV02423	f	f
6481248	4	NAT2	*46	PV02424	f	f
6481250	4	NAT2	*47	PV02425	f	f
6481254	4	NAT2	*49	PV02427	f	f
6481194	4	NAT2	*5	PV02397	f	f
6481258	4	NAT2	*51	PV02640	f	f
779313	158	SLCO1B1	*19	PV01634	f	f
6481262	4	NAT2	*53	PV02644	f	f
6481264	4	NAT2	*54	PV02771	f	f
6481266	4	NAT2	*55	PV02776	f	f
6481268	4	NAT2	*56	PV02783	f	f
6481272	4	NAT2	*58	PV02787	f	f
6481274	4	NAT2	*59	PV02789	f	f
6481196	4	NAT2	*6	PV02398	f	f
6481280	4	NAT2	*62	PV02795	f	f
6481204	4	NAT2	*15	PV02402	f	f
6481282	4	NAT2	*63	PV02797	f	f
6481284	4	NAT2	*64	PV02799	f	f
6481198	4	NAT2	*7	PV02399	f	f
6481286	2	NAT2	*5G	\N	f	f
6481288	2	NAT2	*17	\N	f	f
6481290	2	NAT2	*5J	\N	f	f
6481292	2	NAT2	*5M	\N	f	f
6481294	2	NAT2	*6J	\N	f	f
6481296	2	NAT2	*5U	\N	f	f
779329	158	SLCO1B1	*27	PV01640	f	f
779220	93	RYR1	c.7373G>A	\N	f	f
3685704	32	RYR1	c.7879G>C	\N	f	f
3685734	32	RYR1	c.8654C>G	\N	f	f
3685764	32	RYR1	c.9850T>A	\N	f	f
3685794	32	RYR1	c.11120G>T	\N	f	f
3685824	32	RYR1	c.11958C>G	\N	f	f
3685854	32	RYR1	c.12533G>T	\N	f	f
3685884	32	RYR1	c.13918A>G	\N	f	f
3685914	32	RYR1	c.14422_14423delinsAA	\N	f	f
779088	164	NUDT15	*13	PV01609	f	f
1508724	74	ABCG2	rs2231142 reference (G)	\N	t	f
779090	164	NUDT15	*14	PV01610	f	f
779092	164	NUDT15	*15	PV01611	f	f
779094	164	NUDT15	*16	PV01612	f	f
779446	93	TPMT	*26	\N	f	f
779096	164	NUDT15	*17	PV01613	f	f
779448	93	TPMT	*27	\N	f	f
779450	93	TPMT	*28	\N	f	f
779098	164	NUDT15	*18	PV01614	f	f
6481298	2	NAT2	*7G	\N	f	f
779100	164	NUDT15	*19	PV01615	f	f
779452	93	TPMT	*29	\N	f	f
779454	93	TPMT	*30	\N	f	f
779066	164	NUDT15	*2	PV01598	f	f
779102	164	NUDT15	*20	PV01616	f	f
5881976	14	NUDT15	*21	PV02804	f	f
779068	164	NUDT15	*3	PV01599	f	f
779456	93	TPMT	*31	\N	f	f
779070	164	NUDT15	*4	PV01600	f	f
779072	164	NUDT15	*5	PV01601	f	f
779074	164	NUDT15	*6	PV01602	f	f
779076	164	NUDT15	*7	PV01603	f	f
779078	164	NUDT15	*8	PV01604	f	f
1002699	149	SLCO1B1	*44	PV01656	f	f
779160	93	RYR1	c.742G>A	\N	f	f
3685398	32	RYR1	c.1144C>A	\N	f	f
3685428	32	RYR1	c.1565A>G	\N	f	f
3685458	32	RYR1	c.2537C>T	\N	f	f
3685488	32	RYR1	c.4024A>G	\N	f	f
3685520	32	RYR1	c.5440A>G	\N	f	f
779458	93	TPMT	*32	\N	f	f
779460	93	TPMT	*33	\N	f	f
779462	93	TPMT	*34	\N	f	f
779464	93	TPMT	*35	\N	f	f
779466	93	TPMT	*36	\N	f	f
779468	93	TPMT	*37	\N	f	f
779470	93	TPMT	*38	\N	f	f
779472	93	TPMT	*39	\N	f	f
779474	93	TPMT	*40	\N	f	f
779476	93	TPMT	*41	\N	f	f
779478	93	TPMT	*42	\N	f	f
779480	93	TPMT	*43	\N	f	f
779482	93	TPMT	*44	\N	f	f
779488	93	UGT1A1	*1	\N	t	f
779490	93	UGT1A1	*6	\N	f	f
779492	93	UGT1A1	*27	\N	f	f
779494	93	UGT1A1	*28	\N	f	f
779496	93	UGT1A1	*36	\N	f	f
3685550	32	RYR1	c.6488G>T	\N	f	f
779498	93	UGT1A1	*37	\N	f	f
3685580	32	RYR1	c.6743G>A	\N	f	f
779500	93	UGT1A1	*80	\N	f	f
779502	93	UGT1A1	*80+*28	\N	f	f
779504	93	UGT1A1	*80+*37	\N	f	f
779507	93	VKORC1	rs9923231 reference (C)	\N	t	f
779509	93	VKORC1	rs9923231 variant (T)	\N	f	f
779202	93	RYR1	c.7063C>T	\N	f	f
779206	93	RYR1	c.7282G>A	\N	f	f
3685646	32	RYR1	c.7292A>T	\N	f	f
778218	165	CYP3A5	*1	PV01323	t	f
778222	165	CYP3A5	*3	PV01325	f	f
778230	165	CYP3A5	*7	PV01329	f	f
778232	165	CYP3A5	*8	PV01330	f	f
778234	165	CYP3A5	*9	PV01331	f	f
779064	164	NUDT15	*1	PV01597	t	f
779082	164	NUDT15	*10	PV01606	f	f
779084	164	NUDT15	*11	PV01607	f	f
779086	164	NUDT15	*12	PV01608	f	f
779150	93	RYR1	c.103T>C	\N	f	f
3685312	32	RYR1	c.97A>G	\N	f	f
3318589	64	CYP4F2	*10	PV02318	f	f
3685316	32	RYR1	c.119G>C	\N	f	f
779152	93	RYR1	c.130C>T	\N	f	f
778228	165	CYP3A5	*6	PV01328	f	f
3685320	32	RYR1	c.131G>A	\N	f	f
3685322	32	RYR1	c.152C>A	\N	f	f
3685324	32	RYR1	c.178G>A	\N	f	f
3685326	32	RYR1	c.178G>T	\N	f	f
3685328	32	RYR1	c.190T>C	\N	f	f
3685330	32	RYR1	c.212C>A	\N	f	f
3685332	32	RYR1	c.251C>T	\N	f	f
3685334	32	RYR1	c.418G>A	\N	f	f
3685336	32	RYR1	c.455C>A	\N	f	f
3685338	32	RYR1	c.463C>A	\N	f	f
3685340	32	RYR1	c.467G>A	\N	f	f
3685342	32	RYR1	c.479A>G	\N	f	f
779154	93	RYR1	c.487C>T	\N	f	f
779156	93	RYR1	c.488G>T	\N	f	f
3685348	32	RYR1	c.488G>A	\N	f	f
3685350	32	RYR1	c.493G>A	\N	f	f
3685530	32	RYR1	c.6302T>A	\N	f	f
3685352	32	RYR1	c.496G>A	\N	f	f
3685354	32	RYR1	c.497A>G	\N	f	f
3685356	32	RYR1	c.526G>A	\N	f	f
3685358	32	RYR1	c.528G>T	\N	f	f
3685360	32	RYR1	c.529C>T	\N	f	f
3685362	32	RYR1	c.533A>G	\N	f	f
3685364	32	RYR1	c.533A>C	\N	f	f
3685368	32	RYR1	c.641C>T	\N	f	f
3685370	32	RYR1	c.652G>A	\N	f	f
3685372	32	RYR1	c.677T>A	\N	f	f
3685374	32	RYR1	c.680A>T	\N	f	f
779158	93	RYR1	c.742G>C	\N	f	f
3685380	32	RYR1	c.946C>T	\N	f	f
3685382	32	RYR1	c.947G>T	\N	f	f
779162	93	RYR1	c.982C>T	\N	f	f
3685386	32	RYR1	c.992_994dup	\N	f	f
779164	93	RYR1	c.1021G>A	\N	f	f
779166	93	RYR1	c.1021G>C	\N	f	f
3685392	32	RYR1	c.1024G>A	\N	f	f
3685394	32	RYR1	c.1100G>A	\N	f	f
3685396	32	RYR1	c.1100G>T	\N	f	f
779168	93	RYR1	c.1201C>T	\N	f	f
3685402	32	RYR1	c.1201C>A	\N	f	f
3685404	32	RYR1	c.1201C>G	\N	f	f
3685406	32	RYR1	c.1202G>T	\N	f	f
3685408	32	RYR1	c.1202G>A	\N	f	f
779170	93	RYR1	c.1209C>G	\N	f	f
3685412	32	RYR1	c.1411C>T	\N	f	f
3685414	32	RYR1	c.1422G>T	\N	f	f
3685416	32	RYR1	c.1453A>G	\N	f	f
3685418	32	RYR1	c.1459C>G	\N	f	f
3685420	32	RYR1	c.1460T>C	\N	f	f
3685422	32	RYR1	c.1475G>A	\N	f	f
3685424	32	RYR1	c.1553T>C	\N	f	f
779172	93	RYR1	c.1565A>C	\N	f	f
779174	93	RYR1	c.1589G>A	\N	f	f
779176	93	RYR1	c.1597C>T	\N	f	f
3685434	32	RYR1	c.1597C>A	\N	f	f
779178	93	RYR1	c.1598G>A	\N	f	f
3685438	32	RYR1	c.1615T>C	\N	f	f
3685440	32	RYR1	c.1615T>G	\N	f	f
3685442	32	RYR1	c.1630G>T	\N	f	f
779180	93	RYR1	c.1654C>T	\N	f	f
3685446	32	RYR1	c.1834G>C	\N	f	f
779182	93	RYR1	c.1840C>T	\N	f	f
779184	93	RYR1	c.1841G>T	\N	f	f
3685452	32	RYR1	c.2050G>C	\N	f	f
3685454	32	RYR1	c.2122G>A	\N	f	f
3685456	32	RYR1	c.2447C>T	\N	f	f
3685460	32	RYR1	c.2654G>A	\N	f	f
3685462	32	RYR1	c.2797G>A	\N	f	f
3685464	32	RYR1	c.2924G>A	\N	f	f
3685466	32	RYR1	c.2996G>A	\N	f	f
3685468	32	RYR1	c.3095G>A	\N	f	f
3685470	32	RYR1	c.3127C>T	\N	f	f
3685472	32	RYR1	c.3166G>C	\N	f	f
3685474	32	RYR1	c.3166G>A	\N	f	f
3685476	32	RYR1	c.3172G>A	\N	f	f
3685478	32	RYR1	c.3224G>A	\N	f	f
3685480	32	RYR1	c.3418C>T	\N	f	f
3685482	32	RYR1	c.3527C>T	\N	f	f
3685484	32	RYR1	c.3656A>C	\N	f	f
3685486	32	RYR1	c.3667G>A	\N	f	f
3685490	32	RYR1	c.4178A>G	\N	f	f
3685492	32	RYR1	c.4400A>G	\N	f	f
3685494	32	RYR1	c.4711A>G	\N	f	f
3685496	32	RYR1	c.4747C>T	\N	f	f
3685498	32	RYR1	c.4763C>T	\N	f	f
3685500	32	RYR1	c.4775C>T	\N	f	f
3685502	32	RYR1	c.5024T>C	\N	f	f
3685504	32	RYR1	c.5033A>G	\N	f	f
3685506	32	RYR1	c.5036G>A	\N	f	f
3685508	32	RYR1	c.5132A>G	\N	f	f
3685510	32	RYR1	c.5183C>T	\N	f	f
3685512	32	RYR1	c.5186T>G	\N	f	f
3685514	32	RYR1	c.5317C>T	\N	f	f
3685516	32	RYR1	c.5341T>C	\N	f	f
3685518	32	RYR1	c.5360C>T	\N	f	f
3685522	32	RYR1	c.5441T>A	\N	f	f
3685524	32	RYR1	c.5890C>T	\N	f	f
3685526	32	RYR1	c.6037A>C	\N	f	f
3685528	32	RYR1	c.6178G>T	\N	f	f
3685532	32	RYR1	c.6304G>C	\N	f	f
3685534	32	RYR1	c.6349G>C	\N	f	f
3685536	32	RYR1	c.6377G>A	\N	f	f
3685538	32	RYR1	c.6387C>G	\N	f	f
3685540	32	RYR1	c.6388G>A	\N	f	f
3685542	32	RYR1	c.6478G>A	\N	f	f
779186	93	RYR1	c.6487C>T	\N	f	f
779188	93	RYR1	c.6488G>A	\N	f	f
3685548	32	RYR1	c.6488G>C	\N	f	f
779190	93	RYR1	c.6502G>A	\N	f	f
3685554	32	RYR1	c.6544A>T	\N	f	f
3685556	32	RYR1	c.6548G>A	\N	f	f
3685558	32	RYR1	c.6599C>T	\N	f	f
3685982	32	RYR1	c.15060G>C	\N	f	f
3318591	64	CYP4F2	*11	PV02320	f	f
779148	93	RYR1	Reference	\N	t	f
3685308	32	RYR1	c.38T>G	\N	f	f
3685310	32	RYR1	c.51_53del	\N	f	f
778238	164	CYP4F2	*1	PV02212	t	f
3685984	32	RYR1	c.14364+1G>T	\N	f	f
778104	165	CYP2D6	*93	PV00510	f	f
778329	93	DPYD	c.46C>G	\N	f	f
778373	93	DPYD	c.1057C>T	\N	f	f
778375	93	DPYD	c.1108A>G	\N	f	f
3942827	25	DPYD	c.1129-5923C>G	\N	f	f
778383	93	DPYD	c.1181G>T	\N	f	f
778385	93	DPYD	c.1218G>A	\N	f	f
778387	93	DPYD	c.1260T>A	\N	f	f
778389	93	DPYD	c.1278G>T	\N	f	f
778391	93	DPYD	c.1294G>A	\N	f	f
778359	93	DPYD	c.775A>G	\N	f	f
778361	93	DPYD	c.868A>G	\N	f	f
778363	93	DPYD	c.929T>C	\N	f	f
778395	93	DPYD	c.1349C>T	\N	f	f
778397	93	DPYD	c.1358C>G	\N	f	f
778158	165	CYP2D6	*120	PV00630	f	f
778399	93	DPYD	c.1371C>T	\N	f	f
778401	93	DPYD	c.1403C>A	\N	f	f
778403	93	DPYD	c.1475C>T	\N	f	f
778407	93	DPYD	c.1519G>A	\N	f	f
778409	93	DPYD	c.1543G>A	\N	f	f
2091248	109	CYP2D6	*158	PV01951	f	f
777960	160	CYP2D6	*13	PV00438	f	t
778377	93	DPYD	c.1129-5923C>G, c.1236G>A (HapB3)	\N	f	f
778379	93	DPYD	c.1156G>T (*12)	\N	f	f
778345	93	DPYD	c.496A>G	\N	f	f
2677041	87	CYP2D6	*165	PV02201	f	f
778381	93	DPYD	c.1180C>T	\N	f	f
778411	93	DPYD	c.1577C>G	\N	f	f
778413	93	DPYD	c.1601G>A (*4)	\N	f	f
778415	93	DPYD	c.1615G>A	\N	f	f
778419	93	DPYD	c.1679T>G (*13)	\N	f	f
778421	93	DPYD	c.1682G>T	\N	f	f
778423	93	DPYD	c.1774C>T	\N	f	f
778425	93	DPYD	c.1775G>A	\N	f	f
778427	93	DPYD	c.1777G>A	\N	f	f
778429	93	DPYD	c.1796T>C	\N	f	f
778431	93	DPYD	c.1896T>C	\N	f	f
778433	93	DPYD	c.1898delC (*3)	\N	f	f
778437	93	DPYD	c.1905+1G>A (*2A)	\N	f	f
778445	93	DPYD	c.2161G>A	\N	f	f
778447	93	DPYD	c.2186C>T	\N	f	f
778449	93	DPYD	c.2194G>A (*6)	\N	f	f
778451	93	DPYD	c.2195T>G	\N	f	f
778455	93	DPYD	c.2303C>A	\N	f	f
778457	93	DPYD	c.2336C>A	\N	f	f
778459	93	DPYD	c.2482G>A	\N	f	f
778461	93	DPYD	c.2582A>G	\N	f	f
778463	93	DPYD	c.2623A>C	\N	f	f
778465	93	DPYD	c.2639G>T	\N	f	f
778467	93	DPYD	c.2656C>T	\N	f	f
778469	93	DPYD	c.2657G>A (*9B)	\N	f	f
778471	93	DPYD	c.2846A>T	\N	f	f
778473	93	DPYD	c.2872A>G	\N	f	f
778475	93	DPYD	c.2915A>G	\N	f	f
778477	93	DPYD	c.2921A>T	\N	f	f
778479	93	DPYD	c.2933A>G	\N	f	f
778481	93	DPYD	c.2978T>G	\N	f	f
778487	93	DPYD	c.3049G>A	\N	f	f
778489	93	DPYD	c.3061G>C	\N	f	f
778491	93	DPYD	c.3067C>A	\N	f	f
3685366	32	RYR1	c.625G>A	\N	f	f
3685560	32	RYR1	c.6612C>G	\N	f	f
779192	93	RYR1	c.6617C>G	\N	f	f
779194	93	RYR1	c.6617C>T	\N	f	f
3685566	32	RYR1	c.6628G>T	\N	f	f
3685568	32	RYR1	c.6635T>A	\N	f	f
3685572	32	RYR1	c.6671G>A	\N	f	f
3685574	32	RYR1	c.6670C>T	\N	f	f
3685576	32	RYR1	c.6710G>A	\N	f	f
3685578	32	RYR1	c.6742C>T	\N	f	f
3685582	32	RYR1	c.6757C>T	\N	f	f
3685584	32	RYR1	c.6838G>A	\N	f	f
3685586	32	RYR1	c.6847A>C	\N	f	f
3685588	32	RYR1	c.6961A>G	\N	f	f
779196	93	RYR1	c.7007G>A	\N	f	f
3685592	32	RYR1	c.7018T>C	\N	f	f
2899144	79	CYP2B6	*40	PV02268	f	f
2899160	79	CYP2B6	*48	PV02284	f	f
777586	165	CYP2C19	*31	PV00625	f	f
777596	160	CYP2C19	*36	PV00730	f	t
777668	165	CYP2C9	*1	PV00537	t	f
777708	165	CYP2C9	*21	PV00557	f	f
777718	165	CYP2C9	*26	PV00562	f	f
777754	165	CYP2C9	*44	PV00580	f	f
777808	165	CYP2C9	*71	PV01444	f	f
778194	165	CYP2D6	*138	PV00722	f	f
778198	165	CYP2D6	*140	PV01361	f	f
778347	93	DPYD	c.498G>A	\N	f	f
778327	93	DPYD	Reference	\N	t	f
778349	93	DPYD	c.525G>A	\N	f	f
778351	93	DPYD	c.557A>G	\N	f	f
778353	93	DPYD	c.601A>C	\N	f	f
778355	93	DPYD	c.632A>G	\N	f	f
1932995	115	CYP2C9	*81	PV01790	f	f
778134	165	CYP2D6	*108	PV00525	f	f
778154	165	CYP2D6	*118	PV00535	f	f
2091240	109	CYP2D6	*154	PV01934	f	f
778365	93	DPYD	c.934C>T	\N	f	f
778367	93	DPYD	c.967G>A	\N	f	f
778393	93	DPYD	c.1314T>G	\N	f	f
778405	93	DPYD	c.1484A>G	\N	f	f
777736	165	CYP2C9	*35	PV00571	f	f
778369	93	DPYD	c.1003G>T (*11)	\N	f	f
778357	93	DPYD	c.703C>T (*8)	\N	f	f
778371	93	DPYD	c.1024G>A	\N	f	f
778417	93	DPYD	c.1627A>G (*5)	\N	f	f
3685570	32	RYR1	c.6640G>A	\N	f	f
778331	93	DPYD	c.61C>T	\N	f	f
778333	93	DPYD	c.62G>A	\N	f	f
778335	93	DPYD	c.85T>C (*9A)	\N	f	f
778339	93	DPYD	c.313G>A	\N	f	f
778341	93	DPYD	c.343A>G	\N	f	f
778343	93	DPYD	c.451A>G	\N	f	f
777422	165	CYP2B6	*1	PV00738	t	f
777424	165	CYP2B6	*2	PV00740	f	f
777426	165	CYP2B6	*3	PV00741	f	f
1508726	74	ABCG2	rs2231142 variant (T)	\N	f	f
777264	93	CACNA1S	c.520C>T	\N	f	f
777315	93	CFTR	711+3A->G	\N	f	f
777309	93	CFTR	2789+5G->A	\N	f	f
777311	93	CFTR	3272-26A->G	\N	f	f
777313	93	CFTR	3849+10kbC->T	\N	f	f
777319	93	CFTR	A455E	\N	f	f
777317	93	CFTR	A1067T	\N	f	f
777321	93	CFTR	D110E	\N	f	f
777323	93	CFTR	D110H	\N	f	f
777329	93	CFTR	D579G	\N	f	f
777325	93	CFTR	D1152H	\N	f	f
777327	93	CFTR	D1270N	\N	f	f
777331	93	CFTR	E193K	\N	f	f
777335	93	CFTR	E831X	\N	f	f
777337	93	CFTR	F1052V	\N	f	f
777347	93	CFTR	G178R	\N	f	f
777349	93	CFTR	G551D	\N	f	f
777351	93	CFTR	G551S	\N	f	f
777341	93	CFTR	G1069R	\N	f	f
777343	93	CFTR	G1244E	\N	f	f
777345	93	CFTR	G1349D	\N	f	f
777353	93	CFTR	K1060T	\N	f	f
777355	93	CFTR	L206W	\N	f	f
777371	93	CFTR	R74W	\N	f	f
777363	93	CFTR	R117C	\N	f	f
777365	93	CFTR	R117H	\N	f	f
777367	93	CFTR	R347H	\N	f	f
777369	93	CFTR	R352Q	\N	f	f
777359	93	CFTR	R1070Q	\N	f	f
777361	93	CFTR	R1070W	\N	f	f
777377	93	CFTR	S549N	\N	f	f
777381	93	CFTR	S549R(T>G)	\N	f	f
777383	93	CFTR	S945L	\N	f	f
777385	93	CFTR	S977F	\N	f	f
777373	93	CFTR	S1251N	\N	f	f
777375	93	CFTR	S1255P	\N	f	f
777582	165	CYP2C19	*29	PV00623	f	f
777584	165	CYP2C19	*30	PV02141	f	f
777588	165	CYP2C19	*32	PV00626	f	f
777590	165	CYP2C19	*33	PV00627	f	f
778160	165	CYP2D6	*121	PV00631	f	f
778174	165	CYP2D6	*128	PV01408	f	f
6481202	4	NAT2	*14	PV02401	f	f
6481214	4	NAT2	*29	PV02407	f	f
6481224	4	NAT2	*34	PV02412	f	f
6481234	4	NAT2	*39	PV02417	f	f
6481242	4	NAT2	*43	PV02421	f	f
6481252	4	NAT2	*48	PV02426	f	f
6481260	4	NAT2	*52	PV02642	f	f
6481270	4	NAT2	*57	PV02785	f	f
6481278	4	NAT2	*61	PV02793	f	f
779295	158	SLCO1B1	*10	PV01627	f	f
777307	93	CFTR	ivacaftor non-responsive CFTR sequence	\N	t	f
6606011	1	CFTR	F508C,S1251N	\N	f	f
778100	165	CYP2D6	*91	PV00508	f	f
778102	165	CYP2D6	*92	PV00509	f	f
778106	165	CYP2D6	*94	PV00511	f	f
778110	165	CYP2D6	*96	PV00513	f	f
778439	93	DPYD	c.1906A>C	\N	f	f
778441	93	DPYD	c.1990G>T	\N	f	f
778443	93	DPYD	c.2021G>A	\N	f	f
6610094	1	CYP2D6	*68+*4	\N	f	f
6610096	1	CYP2D6	*36+*10	\N	f	f
6610098	1	CYP2D6	*13+*1	\N	f	f
6610101	1	CYP2D6	*13+*2	\N	f	f
6610103	1	CYP2D6	*13+*68x2+*4	\N	f	f
6610105	1	CYP2D6	*36x2+*10	\N	f	f
6610108	1	CYP2D6	*68+*2	\N	f	f
778666	94	G6PD	B (reference)	\N	t	f
778748	93	G6PD	A- 680T_376G	\N	f	f
778750	93	G6PD	A- 968C_376G	\N	f	f
6610461	2	NAT2	*65	PV02991	f	f
6610463	2	NAT2	*66	PV02993	f	f
6610465	2	NAT2	*67	PV02995	f	f
6610467	2	NAT2	*68	PV02997	f	f
6610469	2	NAT2	*69	PV02999	f	f
778916	93	G6PD	Aachen	\N	f	f
778962	93	G6PD	Abeno	\N	f	f
778950	93	G6PD	Alhambra	\N	f	f
778702	93	G6PD	Amazonia	\N	f	f
779006	93	G6PD	Amiens	\N	f	f
778700	93	G6PD	Amsterdam	\N	f	f
778956	93	G6PD	Anadia	\N	f	f
778746	93	G6PD	Ananindeua	\N	f	f
779036	93	G6PD	Arakawa	\N	f	f
778708	93	G6PD	Asahi	\N	f	f
778686	93	G6PD	Aures	\N	f	f
778836	93	G6PD	Aveiro	\N	f	f
778858	93	G6PD	Bajo Maumere	\N	f	f
778844	93	G6PD	Bangkok	\N	f	f
779008	93	G6PD	Bangkok Noi	\N	f	f
778738	93	G6PD	Bao Loc	\N	f	f
778952	93	G6PD	Bari	\N	f	f
778766	93	G6PD	Belem	\N	f	f
779034	93	G6PD	Buenos Aires	\N	f	f
778762	93	G6PD	Cairo	\N	f	f
778922	93	G6PD	Calvo Mackenna	\N	f	f
779032	93	G6PD	Campinas	\N	f	f
779012	93	G6PD	Canton, Taiwan-Hakka, Gifu-like, Agrigento-like	\N	f	f
778994	93	G6PD	Cassano	\N	f	f
778894	93	G6PD	Chatham	\N	f	f
778794	93	G6PD	Chikugo	\N	f	f
778854	93	G6PD	Chinese-1	\N	f	f
778900	93	G6PD	Chinese-5	\N	f	f
778816	93	G6PD	Cincinnati	\N	f	f
778840	93	G6PD	Cleveland Corum	\N	f	f
778740	93	G6PD	Crispim	\N	f	f
778810	93	G6PD	Dagua	\N	f	f
778830	93	G6PD	Durham	\N	f	f
778888	93	G6PD	Farroupilha	\N	f	f
779004	93	G6PD	Figuera da Foz	\N	f	f
779018	93	G6PD	Flores	\N	f	f
779030	93	G6PD	Fukaya	\N	f	f
778896	93	G6PD	Fushan	\N	f	f
778674	93	G6PD	Gaohe	\N	f	f
778978	93	G6PD	Georgia	\N	f	f
778680	93	G6PD	Gidra	\N	f	f
778936	93	G6PD	Guadalajara	\N	f	f
778698	93	G6PD	Costanzo	\N	f	f
778958	93	G6PD	Covao do Lobo	\N	f	f
778726	93	G6PD	Guangzhou	\N	f	f
778852	93	G6PD	Haikou	\N	f	f
778734	93	G6PD	Hammersmith	\N	f	f
778818	93	G6PD	Harilaou	\N	f	f
778998	93	G6PD	Harima	\N	f	f
778940	93	G6PD	Hartford	\N	f	f
778710	93	G6PD	Hechi	\N	f	f
778996	93	G6PD	Hermoupolis	\N	f	f
778676	93	G6PD	Honiara	\N	f	f
778770	93	G6PD	Ilesha	\N	f	f
778890	93	G6PD	Insuli	\N	f	f
778934	93	G6PD	Iowa, Walter Reed, Springfield	\N	f	f
778908	93	G6PD	Iwatsuki	\N	f	f
778970	93	G6PD	Japan, Shinagawa	\N	f	f
779022	93	G6PD	Kaiping, Anant, Dhon, Sapporo-like, Wosera	\N	f	f
778880	93	G6PD	Kalyan-Kerala, Jamnaga, Rohini	\N	f	f
778688	93	G6PD	Kambos	\N	f	f
779016	93	G6PD	Kamiube, Keelung	\N	f	f
778692	93	G6PD	Kamogawa	\N	f	f
778972	93	G6PD	Kawasaki	\N	f	f
778690	93	G6PD	Kozukata	\N	f	f
778944	93	G6PD	Krakow	\N	f	f
778848	93	G6PD	La Jolla	\N	f	f
778672	93	G6PD	Lages	\N	f	f
779026	93	G6PD	Laibin	\N	f	f
778842	93	G6PD	Lille	\N	f	f
778768	93	G6PD	Liuzhou	\N	f	f
778914	93	G6PD	Loma Linda	\N	f	f
778878	93	G6PD	Ludhiana	\N	f	f
778930	93	G6PD	Lynwood	\N	f	f
778932	93	G6PD	Madrid	\N	f	f
778776	93	G6PD	Mahidol	\N	f	f
778796	93	G6PD	Malaga	\N	f	f
778884	93	G6PD	Manhattan	\N	f	f
778984	93	G6PD	Mediterranean Haplotype	\N	f	f
778696	93	G6PD	Metaponto	\N	f	f
778822	93	G6PD	Mexico City	\N	f	f
778790	93	G6PD	Miaoli	\N	f	f
778814	93	G6PD	Minnesota, Marion, Gastonia, LeJeune	\N	f	f
778902	93	G6PD	Mira d'Aire	\N	f	f
778860	93	G6PD	Mizushima	\N	f	f
778868	93	G6PD	Montalbano	\N	f	f
778920	93	G6PD	Montpellier	\N	f	f
778754	93	G6PD	Mt Sinai	\N	f	f
778974	93	G6PD	Munich	\N	f	f
778718	93	G6PD	Murcia Oristano	\N	f	f
778704	93	G6PD	Musashino	\N	f	f
778716	93	G6PD	Namouru	\N	f	f
778788	93	G6PD	Nankang	\N	f	f
778828	93	G6PD	Nanning	\N	f	f
778784	93	G6PD	Naone	\N	f	f
778882	93	G6PD	Nara	\N	f	f
778948	93	G6PD	Nashville, Anaheim, Portici	\N	f	f
779024	93	G6PD	Neapolis	\N	f	f
779014	93	G6PD	Nice	\N	f	f
778808	93	G6PD	Nilgiri	\N	f	f
778668	93	G6PD	No name	\N	f	f
778824	93	G6PD	North Dallas	\N	f	f
778926	93	G6PD	Olomouc	\N	f	f
778876	93	G6PD	Omiya	\N	f	f
778684	93	G6PD	Orissa	\N	f	f
778866	93	G6PD	Osaka	\N	f	f
778694	93	G6PD	Palestrina	\N	f	f
778862	93	G6PD	Papua	\N	f	f
778904	93	G6PD	Partenope	\N	f	f
778986	93	G6PD	Pawnee	\N	f	f
778864	93	G6PD	Piotrkow	\N	f	f
778778	93	G6PD	Plymouth	\N	f	f
778942	93	G6PD	Praha	\N	f	f
778760	93	G6PD	Quing Yan	\N	f	f
778820	93	G6PD	Radlowo	\N	f	f
778886	93	G6PD	Rehevot	\N	f	f
778682	93	G6PD	Rignano	\N	f	f
778924	93	G6PD	Riley	\N	f	f
778968	93	G6PD	Riverside	\N	f	f
778838	93	G6PD	Roubaix	\N	f	f
778992	93	G6PD	S. Antioco	\N	f	f
778758	93	G6PD	Salerno Pyrgos	\N	f	f
778806	93	G6PD	Santiago	\N	f	f
778736	93	G6PD	Sao Borja	\N	f	f
778856	93	G6PD	Seattle, Lodi, Modena, Ferrara II, Athens-like	\N	f	f
778874	93	G6PD	Seoul	\N	f	f
778910	93	G6PD	Serres	\N	f	f
778772	93	G6PD	Shenzen	\N	f	f
778792	93	G6PD	Shinshu	\N	f	f
778812	93	G6PD	Sibari	\N	f	f
778730	93	G6PD	Sierra Leone	\N	f	f
778670	93	G6PD	Sinnai	\N	f	f
778706	93	G6PD	Songklanagarind	\N	f	f
779028	93	G6PD	Split	\N	f	f
778832	93	G6PD	Stonybrook	\N	f	f
778846	93	G6PD	Sugao	\N	f	f
778982	93	G6PD	Sumare	\N	f	f
778678	93	G6PD	Sunderland	\N	f	f
778980	93	G6PD	Surabaya	\N	f	f
778966	93	G6PD	Suwalki	\N	f	f
778720	93	G6PD	Swansea	\N	f	f
3564276	34	G6PD	Telti, Kobe	\N	f	f
778918	93	G6PD	Tenri	\N	f	f
778976	93	G6PD	Tokyo, Fukushima	\N	f	f
778782	93	G6PD	Toledo	\N	f	f
778928	93	G6PD	Tomah	\N	f	f
778912	93	G6PD	Tondela	\N	f	f
778898	93	G6PD	Torun	\N	f	f
778798	93	G6PD	Tsukui	\N	f	f
778722	93	G6PD	Ube Konan	\N	f	f
779000	93	G6PD	Union,Maewo, Chinese-2, Kalo	\N	f	f
778728	93	G6PD	Urayasu	\N	f	f
778964	93	G6PD	Utrecht	\N	f	f
778764	93	G6PD	Valladolid	\N	f	f
778732	93	G6PD	Vancouver	\N	f	f
778756	93	G6PD	Vanua Lava	\N	f	f
778870	93	G6PD	Viangchan, Jammu	\N	f	f
778892	93	G6PD	Villeurbanne	\N	f	f
778786	93	G6PD	Volendam	\N	f	f
778834	93	G6PD	Wayne	\N	f	f
778850	93	G6PD	Wexham	\N	f	f
778960	93	G6PD	Clinic	\N	f	f
778804	93	G6PD	Coimbra Shunde	\N	f	f
779010	93	G6PD	Cosenza	\N	f	f
3685600	32	RYR1	c.7036G>A	\N	f	f
779198	93	RYR1	c.7042_7044delGAG	\N	f	f
3685604	32	RYR1	c.7043A>G	\N	f	f
779200	93	RYR1	c.7048G>A	\N	f	f
3685608	32	RYR1	c.7060G>A	\N	f	f
3685612	32	RYR1	c.7073T>A	\N	f	f
3685596	32	RYR1	c.7032G>C	\N	f	f
3685598	32	RYR1	c.7035C>A	\N	f	f
3685614	32	RYR1	c.7076G>A	\N	f	f
3685616	32	RYR1	c.7075C>T	\N	f	f
3685618	32	RYR1	c.7084G>A	\N	f	f
3685620	32	RYR1	c.7085A>G	\N	f	f
3685622	32	RYR1	c.7089C>G	\N	f	f
3685624	32	RYR1	c.7090T>G	\N	f	f
3685626	32	RYR1	c.7097C>G	\N	f	f
3685628	32	RYR1	c.7099G>A	\N	f	f
3685630	32	RYR1	c.7112A>G	\N	f	f
3685632	32	RYR1	c.7123G>A	\N	f	f
779204	93	RYR1	c.7124G>C	\N	f	f
3685636	32	RYR1	c.7199A>G	\N	f	f
3685638	32	RYR1	c.7210G>A	\N	f	f
3685642	32	RYR1	c.7291G>A	\N	f	f
3685644	32	RYR1	c.7291G>T	\N	f	f
779208	93	RYR1	c.7300G>A	\N	f	f
779210	93	RYR1	c.7304G>A	\N	f	f
3685652	32	RYR1	c.7304G>T	\N	f	f
3685654	32	RYR1	c.7307G>A	\N	f	f
3685656	32	RYR1	c.7310C>T	\N	f	f
3685658	32	RYR1	c.7317G>C	\N	f	f
779212	93	RYR1	c.7354C>T	\N	f	f
3685662	32	RYR1	c.7355G>A	\N	f	f
3685664	32	RYR1	c.7355G>C	\N	f	f
3685666	32	RYR1	c.7358T>C	\N	f	f
779214	93	RYR1	c.7360C>T	\N	f	f
779216	93	RYR1	c.7361G>A	\N	f	f
779218	93	RYR1	c.7372C>T	\N	f	f
3685676	32	RYR1	c.7373G>T	\N	f	f
3685678	32	RYR1	c.7385C>T	\N	f	f
3685680	32	RYR1	c.7487C>T	\N	f	f
779222	93	RYR1	c.7522C>T	\N	f	f
779224	93	RYR1	c.7522C>G	\N	f	f
779226	93	RYR1	c.7523G>A	\N	f	f
3685688	32	RYR1	c.7528T>C	\N	f	f
3685690	32	RYR1	c.7760A>G	\N	f	f
3685692	32	RYR1	c.7771C>G	\N	f	f
3685696	32	RYR1	c.7777C>G	\N	f	f
3685698	32	RYR1	c.7778G>A	\N	f	f
3685700	32	RYR1	c.7787C>T	\N	f	f
3685702	32	RYR1	c.7816T>A	\N	f	f
3685706	32	RYR1	c.7879G>A	\N	f	f
3685708	32	RYR1	c.8005G>A	\N	f	f
3685710	32	RYR1	c.8026C>T	\N	f	f
3685712	32	RYR1	c.8054C>T	\N	f	f
3685714	32	RYR1	c.8188G>C	\N	f	f
3685716	32	RYR1	c.8189A>G	\N	f	f
3685718	32	RYR1	c.8198G>A	\N	f	f
3685720	32	RYR1	c.8290G>A	\N	f	f
3685722	32	RYR1	c.8327C>T	\N	f	f
3685724	32	RYR1	c.8360C>G	\N	f	f
3685728	32	RYR1	c.8527T>C	\N	f	f
3685730	32	RYR1	c.8600T>A	\N	f	f
3685732	32	RYR1	c.8638G>A	\N	f	f
3685736	32	RYR1	c.8729C>T	\N	f	f
3685738	32	RYR1	c.8926C>T	\N	f	f
3685740	32	RYR1	c.9152G>A	\N	f	f
3685742	32	RYR1	c.9268G>A	\N	f	f
779228	93	RYR1	c.9310G>A	\N	f	f
3685746	32	RYR1	c.9356G>A	\N	f	f
3685748	32	RYR1	c.9499C>T	\N	f	f
3685750	32	RYR1	c.9635A>G	\N	f	f
3685752	32	RYR1	c.9649T>C	\N	f	f
3685754	32	RYR1	c.9652G>A	\N	f	f
3685756	32	RYR1	c.9676G>C	\N	f	f
3685760	32	RYR1	c.9797T>C	\N	f	f
3685762	32	RYR1	c.9848G>A	\N	f	f
3685766	32	RYR1	c.9868G>A	\N	f	f
3685768	32	RYR1	c.10042C>T	\N	f	f
3685770	32	RYR1	c.10043G>A	\N	f	f
3685772	32	RYR1	c.10097G>A	\N	f	f
3685774	32	RYR1	c.10100A>G	\N	f	f
3685776	32	RYR1	c.10229C>A	\N	f	f
3685778	32	RYR1	c.10237A>T	\N	f	f
3685780	32	RYR1	c.10252A>G	\N	f	f
3685782	32	RYR1	c.10556C>T	\N	f	f
3685784	32	RYR1	c.10616G>A	\N	f	f
3685786	32	RYR1	c.10747G>C	\N	f	f
3685788	32	RYR1	c.10750G>C	\N	f	f
3685792	32	RYR1	c.11086G>C	\N	f	f
3685796	32	RYR1	c.11126C>T	\N	f	f
3685798	32	RYR1	c.11132C>T	\N	f	f
3685800	32	RYR1	c.11266C>G	\N	f	f
3685802	32	RYR1	c.11315G>A	\N	f	f
3685804	32	RYR1	c.11314C>T	\N	f	f
3685806	32	RYR1	c.11416G>A	\N	f	f
3685808	32	RYR1	c.11518G>A	\N	f	f
3685810	32	RYR1	c.11708G>A	\N	f	f
3685812	32	RYR1	c.11723A>T	\N	f	f
3685814	32	RYR1	c.11748T>G	\N	f	f
3685816	32	RYR1	c.11798A>G	\N	f	f
3685818	32	RYR1	c.11813G>A	\N	f	f
3685820	32	RYR1	c.11947C>T	\N	f	f
779230	93	RYR1	c.11969G>T	\N	f	f
3685828	32	RYR1	c.12028G>A	\N	f	f
3685830	32	RYR1	c.12064A>G	\N	f	f
3685832	32	RYR1	c.12115A>T	\N	f	f
3685834	32	RYR1	c.12121C>T	\N	f	f
3685836	32	RYR1	c.12149C>A	\N	f	f
3685838	32	RYR1	c.12242C>T	\N	f	f
3685840	32	RYR1	c.12310G>C	\N	f	f
3685842	32	RYR1	c.12355A>T	\N	f	f
3685844	32	RYR1	c.12383C>T	\N	f	f
3685846	32	RYR1	c.12398A>G	\N	f	f
3685848	32	RYR1	c.12406C>A	\N	f	f
3685850	32	RYR1	c.12413T>C	\N	f	f
3685852	32	RYR1	c.12532G>A	\N	f	f
3685858	32	RYR1	c.12689T>G	\N	f	f
3685860	32	RYR1	c.12700G>C	\N	f	f
3685862	32	RYR1	c.12700G>T	\N	f	f
3685864	32	RYR1	c.12848A>T	\N	f	f
3685866	32	RYR1	c.12881C>T	\N	f	f
3685868	32	RYR1	c.12884C>T	\N	f	f
3685870	32	RYR1	c.13505A>G	\N	f	f
3685872	32	RYR1	c.13513G>C	\N	f	f
778946	93	G6PD	Wisconsin	\N	f	f
779020	93	G6PD	Yunan	\N	f	f
3685594	32	RYR1	c.7025A>G	\N	f	f
\.


--
-- Data for Name: allele_frequency; Type: TABLE DATA; Schema: cpic; Owner: -
--

COPY cpic.allele_frequency (alleleid, population, frequency, label, version) FROM stdin;
1508725	6721027	0.926	0.9260	1
1508727	6721027	0.074	0.0740	1
1508725	6721028	0.99	0.9900	1
1508727	6721028	0.01	0.0100	1
1508725	6721029	0.8	0.8000	1
1508727	6721029	0.2	0.2000	1
1508725	6721030	0.9068	0.9068	1
1508727	6721030	0.0932	0.0932	1
1508725	6721031	0.6929	0.6929	1
1508727	6721031	0.3071	0.3071	1
1508725	6721032	0.8964	0.8964	1
1508727	6721032	0.1036	0.1036	1
1508725	6721033	0.7756	0.7756	1
1508727	6721033	0.2244	0.2244	1
1508725	6721034	0.9347	0.9347	1
1508727	6721034	0.0653	0.0653	1
1508725	6721035	0.903	0.9030	1
1508727	6721035	0.097	0.0970	1
1508725	6721036	0.893	0.8930	1
1508727	6721036	0.107	0.1070	1
1508725	6721037	0.798	0.7980	1
1508727	6721037	0.202	0.2020	1
1508725	6721038	0.561	0.5610	1
1508727	6721038	0.439	0.4390	1
1508725	6721039	1	1.0000	1
1508727	6721039	0	0.0	1
1508725	6721040	1	1.0000	1
1508727	6721040	0	0.0	1
1508725	6721041	0.987	0.9870	1
1508727	6721041	0.013	0.0130	1
1508725	6721042	0.982	0.9820	1
1508727	6721042	0.018	0.0180	1
1508725	6721043	1	1.0000	1
1508727	6721043	0	0.0	1
777265	6721044	0.00003267	3.267E-5	1
777267	6721044	\N	\N	1
777265	6721045	\N	\N	1
777267	6721045	0	0.0	1
777265	6721046	0.0001087	1.087E-4	1
777267	6721046	0	0.0	1
777265	6721047	0.00001759	1.759E-5	1
777267	6721047	\N	\N	1
777265	6721048	0	0.0	1
777267	6721048	\N	\N	1
777265	6721049	\N	\N	1
777267	6721049	0	0.0	1
777265	6721050	\N	\N	1
777267	6721050	0	0.0	1
777265	6721051	0.00005783	5.783E-5	1
777267	6721051	\N	\N	1
777265	6721052	\N	\N	1
777267	6721052	0.00002891	2.891E-5	1
777265	6721053	0	0.0	1
777267	6721053	\N	\N	1
777265	6721054	\N	\N	1
777267	6721054	0	0.0	1
778233	6722376	\N	\N	1
777425	6721055	\N	\N	1
777427	6721055	0	0.0	1
777429	6721055	\N	\N	1
777431	6721055	\N	\N	1
777433	6721055	\N	\N	1
777435	6721055	\N	\N	1
777437	6721055	\N	\N	1
777439	6721055	\N	\N	1
777441	6721055	\N	\N	1
777443	6721055	\N	\N	1
777445	6721055	\N	\N	1
777447	6721055	\N	\N	1
777449	6721055	\N	\N	1
777451	6721055	\N	\N	1
777453	6721055	\N	\N	1
777455	6721055	\N	\N	1
777457	6721055	\N	\N	1
777459	6721055	\N	\N	1
777461	6721055	\N	\N	1
777463	6721055	\N	\N	1
777465	6721055	\N	\N	1
777467	6721055	\N	\N	1
777469	6721055	\N	\N	1
777471	6721055	\N	\N	1
777473	6721055	\N	\N	1
777475	6721055	\N	\N	1
777477	6721055	\N	\N	1
777479	6721055	\N	\N	1
777481	6721055	\N	\N	1
777483	6721055	\N	\N	1
777485	6721055	\N	\N	1
777487	6721055	\N	\N	1
777489	6721055	\N	\N	1
777491	6721055	\N	\N	1
777493	6721055	\N	\N	1
777495	6721055	\N	\N	1
777425	6721056	\N	\N	1
777427	6721056	\N	\N	1
777429	6721056	\N	\N	1
777431	6721056	\N	\N	1
777433	6721056	0.35	0.35	1
777435	6721056	\N	\N	1
777437	6721056	\N	\N	1
777439	6721056	\N	\N	1
777441	6721056	\N	\N	1
777443	6721056	\N	\N	1
777445	6721056	\N	\N	1
777447	6721056	\N	\N	1
777449	6721056	\N	\N	1
777451	6721056	\N	\N	1
777453	6721056	\N	\N	1
777455	6721056	0.04	0.04	1
777457	6721056	\N	\N	1
777459	6721056	\N	\N	1
777461	6721056	\N	\N	1
777463	6721056	\N	\N	1
777465	6721056	\N	\N	1
777467	6721056	\N	\N	1
777469	6721056	\N	\N	1
777471	6721056	\N	\N	1
777473	6721056	\N	\N	1
777475	6721056	\N	\N	1
777477	6721056	\N	\N	1
777479	6721056	\N	\N	1
777481	6721056	\N	\N	1
777483	6721056	\N	\N	1
777485	6721056	\N	\N	1
777487	6721056	\N	\N	1
777489	6721056	\N	\N	1
777491	6721056	\N	\N	1
777493	6721056	\N	\N	1
777495	6721056	\N	\N	1
777425	6721057	\N	\N	1
777427	6721057	\N	\N	1
777429	6721057	\N	\N	1
777431	6721057	\N	\N	1
777433	6721057	\N	\N	1
777435	6721057	\N	\N	1
777437	6721057	\N	\N	1
777439	6721057	\N	\N	1
777441	6721057	\N	\N	1
777443	6721057	0.003	0.003	1
777445	6721057	\N	\N	1
777447	6721057	\N	\N	1
777449	6721057	\N	\N	1
777451	6721057	\N	\N	1
777453	6721057	\N	\N	1
777455	6721057	\N	\N	1
777457	6721057	\N	\N	1
777459	6721057	\N	\N	1
777461	6721057	\N	\N	1
777463	6721057	\N	\N	1
777465	6721057	\N	\N	1
777467	6721057	\N	\N	1
777469	6721057	\N	\N	1
777471	6721057	\N	\N	1
777473	6721057	\N	\N	1
777475	6721057	\N	\N	1
777477	6721057	\N	\N	1
777479	6721057	\N	\N	1
777481	6721057	\N	\N	1
777483	6721057	\N	\N	1
777485	6721057	\N	\N	1
777487	6721057	\N	\N	1
777489	6721057	\N	\N	1
777491	6721057	\N	\N	1
777493	6721057	\N	\N	1
777495	6721057	\N	\N	1
777425	6721058	0.043	0.043	1
777427	6721058	0	0.0	1
777429	6721058	0	0.0	1
777431	6721058	0.086	0.086	1
777433	6721058	0.328	0.328	1
777435	6721058	0	0.0	1
777423	6721056	0.61	0.61	2
777423	6721057	0.997	0.997	2
777437	6721058	0	0.0	1
777439	6721058	0	0.0	1
777441	6721058	\N	\N	1
777443	6721058	\N	\N	1
777445	6721058	\N	\N	1
777447	6721058	\N	\N	1
777449	6721058	\N	\N	1
777451	6721058	\N	\N	1
777453	6721058	0.071	0.071	1
777455	6721058	0.029	0.029	1
777457	6721058	0	0.0	1
777459	6721058	0	0.0	1
777461	6721058	0	0.0	1
777463	6721058	0.011	0.011	1
777465	6721058	\N	\N	1
777467	6721058	\N	\N	1
777469	6721058	\N	\N	1
777471	6721058	\N	\N	1
777473	6721058	\N	\N	1
777475	6721058	\N	\N	1
777477	6721058	\N	\N	1
777479	6721058	\N	\N	1
777481	6721058	\N	\N	1
777483	6721058	\N	\N	1
777485	6721058	\N	\N	1
777487	6721058	\N	\N	1
777489	6721058	\N	\N	1
777491	6721058	\N	\N	1
777493	6721058	\N	\N	1
777495	6721058	\N	\N	1
777425	6721059	0	0.0	1
777427	6721059	\N	\N	1
777429	6721059	0.037	0.037	1
777431	6721059	0	0.0	1
777433	6721059	0.259	0.259	1
777435	6721059	0	0.0	1
777437	6721059	\N	\N	1
777439	6721059	0.167	0.167	1
777441	6721059	\N	\N	1
777443	6721059	\N	\N	1
777445	6721059	\N	\N	1
777447	6721059	\N	\N	1
777449	6721059	\N	\N	1
777451	6721059	\N	\N	1
777453	6721059	\N	\N	1
777455	6721059	0.037	0.037	1
777457	6721059	\N	\N	1
777459	6721059	\N	\N	1
777461	6721059	\N	\N	1
777463	6721059	\N	\N	1
777465	6721059	\N	\N	1
777467	6721059	\N	\N	1
777469	6721059	\N	\N	1
777471	6721059	\N	\N	1
777473	6721059	\N	\N	1
777475	6721059	\N	\N	1
777477	6721059	\N	\N	1
777479	6721059	\N	\N	1
777481	6721059	\N	\N	1
777483	6721059	\N	\N	1
777485	6721059	\N	\N	1
777487	6721059	\N	\N	1
777489	6721059	\N	\N	1
777491	6721059	\N	\N	1
777493	6721059	\N	\N	1
777495	6721059	\N	\N	1
777425	6721060	\N	\N	1
777427	6721060	0.008	0.008	1
777429	6721060	\N	\N	1
777431	6721060	\N	\N	1
777433	6721060	\N	\N	1
777435	6721060	\N	\N	1
777437	6721060	\N	\N	1
777439	6721060	\N	\N	1
777441	6721060	\N	\N	1
777443	6721060	0	0.0	1
777445	6721060	0	0.0	1
777447	6721060	\N	\N	1
777449	6721060	0	0.0	1
777451	6721060	0	0.0	1
777453	6721060	\N	\N	1
777455	6721060	\N	\N	1
777457	6721060	\N	\N	1
777459	6721060	\N	\N	1
777461	6721060	\N	\N	1
777463	6721060	\N	\N	1
777465	6721060	0	0.0	1
777467	6721060	\N	\N	1
777469	6721060	\N	\N	1
777471	6721060	\N	\N	1
777473	6721060	\N	\N	1
777475	6721060	\N	\N	1
777477	6721060	\N	\N	1
777479	6721060	\N	\N	1
777481	6721060	\N	\N	1
777483	6721060	\N	\N	1
777485	6721060	\N	\N	1
777487	6721060	\N	\N	1
777489	6721060	\N	\N	1
777491	6721060	\N	\N	1
777493	6721060	\N	\N	1
777495	6721060	\N	\N	1
778235	6722376	\N	\N	1
777425	6721061	\N	\N	1
777427	6721061	0	0.0	1
777429	6721061	\N	\N	1
777431	6721061	\N	\N	1
777433	6721061	\N	\N	1
777435	6721061	\N	\N	1
777437	6721061	\N	\N	1
777439	6721061	\N	\N	1
777441	6721061	\N	\N	1
777443	6721061	0	0.0	1
777445	6721061	0	0.0	1
777447	6721061	\N	\N	1
777449	6721061	0	0.0	1
777451	6721061	0	0.0	1
777453	6721061	\N	\N	1
777455	6721061	\N	\N	1
777457	6721061	\N	\N	1
777459	6721061	\N	\N	1
777461	6721061	\N	\N	1
777463	6721061	\N	\N	1
777465	6721061	0.005	0.005	1
777467	6721061	\N	\N	1
777469	6721061	\N	\N	1
777471	6721061	\N	\N	1
777473	6721061	\N	\N	1
777475	6721061	\N	\N	1
777477	6721061	\N	\N	1
777479	6721061	\N	\N	1
777481	6721061	\N	\N	1
777483	6721061	\N	\N	1
777485	6721061	\N	\N	1
777487	6721061	\N	\N	1
777489	6721061	\N	\N	1
777491	6721061	\N	\N	1
777493	6721061	\N	\N	1
777495	6721061	\N	\N	1
777425	6721062	\N	\N	1
777427	6721062	0	0.0	1
777429	6721062	\N	\N	1
777431	6721062	\N	\N	1
777433	6721062	\N	\N	1
777435	6721062	\N	\N	1
777437	6721062	\N	\N	1
777439	6721062	\N	\N	1
777441	6721062	\N	\N	1
777443	6721062	0	0.0	1
777445	6721062	0	0.0	1
777447	6721062	\N	\N	1
777449	6721062	0	0.0	1
777451	6721062	0	0.0	1
777453	6721062	\N	\N	1
777455	6721062	\N	\N	1
777457	6721062	\N	\N	1
777459	6721062	\N	\N	1
777461	6721062	\N	\N	1
777463	6721062	\N	\N	1
777465	6721062	0	0.0	1
777467	6721062	\N	\N	1
777469	6721062	\N	\N	1
777471	6721062	\N	\N	1
777473	6721062	\N	\N	1
777475	6721062	\N	\N	1
777477	6721062	\N	\N	1
777479	6721062	\N	\N	1
777481	6721062	\N	\N	1
777483	6721062	\N	\N	1
777485	6721062	\N	\N	1
777487	6721062	\N	\N	1
777489	6721062	\N	\N	1
777491	6721062	\N	\N	1
777493	6721062	\N	\N	1
777495	6721062	\N	\N	1
777423	6721063	0.994	0.994	2
777423	6721060	0.992	0.992	2
777423	6721059	0.5	0.5	2
777425	6721063	\N	\N	1
777427	6721063	0	0.0	1
777429	6721063	\N	\N	1
777431	6721063	\N	\N	1
777433	6721063	\N	\N	1
777435	6721063	\N	\N	1
777437	6721063	\N	\N	1
777439	6721063	\N	\N	1
777441	6721063	\N	\N	1
777443	6721063	0.006	0.006	1
777445	6721063	0	0.0	1
777447	6721063	\N	\N	1
777449	6721063	0	0.0	1
777451	6721063	0	0.0	1
777453	6721063	\N	\N	1
777455	6721063	\N	\N	1
777457	6721063	\N	\N	1
777459	6721063	\N	\N	1
777461	6721063	\N	\N	1
777463	6721063	\N	\N	1
777465	6721063	0	0.0	1
777467	6721063	\N	\N	1
777469	6721063	\N	\N	1
777471	6721063	\N	\N	1
777473	6721063	\N	\N	1
777475	6721063	\N	\N	1
777477	6721063	\N	\N	1
777479	6721063	\N	\N	1
777481	6721063	\N	\N	1
777483	6721063	\N	\N	1
777485	6721063	\N	\N	1
777487	6721063	\N	\N	1
777489	6721063	\N	\N	1
777491	6721063	\N	\N	1
777493	6721063	\N	\N	1
777495	6721063	\N	\N	1
777425	6721064	\N	\N	1
777427	6721064	0.005	0.005	1
777429	6721064	\N	\N	1
777431	6721064	\N	\N	1
777433	6721064	\N	\N	1
777435	6721064	\N	\N	1
777437	6721064	\N	\N	1
777439	6721064	\N	\N	1
777441	6721064	\N	\N	1
777443	6721064	0	0.0	1
777445	6721064	0	0.0	1
777447	6721064	\N	\N	1
777449	6721064	0	0.0	1
777451	6721064	0	0.0	1
777453	6721064	\N	\N	1
777455	6721064	\N	\N	1
777457	6721064	\N	\N	1
777459	6721064	\N	\N	1
777461	6721064	\N	\N	1
777463	6721064	\N	\N	1
777465	6721064	0	0.0	1
777467	6721064	\N	\N	1
777469	6721064	\N	\N	1
777471	6721064	\N	\N	1
777473	6721064	\N	\N	1
777475	6721064	\N	\N	1
777477	6721064	\N	\N	1
777479	6721064	\N	\N	1
777481	6721064	\N	\N	1
777483	6721064	\N	\N	1
777485	6721064	\N	\N	1
777487	6721064	\N	\N	1
777489	6721064	\N	\N	1
777491	6721064	\N	\N	1
777493	6721064	\N	\N	1
777495	6721064	\N	\N	1
777425	6721065	\N	\N	1
777427	6721065	0.005	0.005	1
777429	6721065	\N	\N	1
777431	6721065	\N	\N	1
777433	6721065	\N	\N	1
777435	6721065	\N	\N	1
777437	6721065	\N	\N	1
777439	6721065	\N	\N	1
777441	6721065	\N	\N	1
777443	6721065	0	0.0	1
777445	6721065	0	0.0	1
777447	6721065	\N	\N	1
777449	6721065	0	0.0	1
777451	6721065	0	0.0	1
777453	6721065	\N	\N	1
777455	6721065	\N	\N	1
777457	6721065	\N	\N	1
777459	6721065	\N	\N	1
777461	6721065	\N	\N	1
777463	6721065	\N	\N	1
777465	6721065	0	0.0	1
777467	6721065	\N	\N	1
777469	6721065	\N	\N	1
777471	6721065	\N	\N	1
777473	6721065	\N	\N	1
777475	6721065	\N	\N	1
777477	6721065	\N	\N	1
777479	6721065	\N	\N	1
777481	6721065	\N	\N	1
777483	6721065	\N	\N	1
777485	6721065	\N	\N	1
777487	6721065	\N	\N	1
777489	6721065	\N	\N	1
777491	6721065	\N	\N	1
777493	6721065	\N	\N	1
777495	6721065	\N	\N	1
777425	6721066	\N	\N	1
777427	6721066	0.002456	0.002456	1
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777423	6721097	0.5634	0.56340003	2
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777423	6721106	1	1.0	2
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777479	6721108	\N	\N	1
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778231	6722376	\N	\N	1
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777433	6721109	0.23	0.23	1
777435	6721109	\N	\N	1
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777493	6721109	\N	\N	1
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777433	6721110	0.25	0.25	1
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777451	6721110	\N	\N	1
777453	6721110	\N	\N	1
777455	6721110	0.05	0.05	1
777457	6721110	\N	\N	1
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777461	6721110	\N	\N	1
777463	6721110	\N	\N	1
777465	6721110	\N	\N	1
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777471	6721110	\N	\N	1
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777437	6721111	\N	\N	1
777439	6721111	\N	\N	1
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777443	6721111	0	0.0	1
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777423	6721108	0.971	0.971	2
777423	6721107	0.995	0.995	2
777481	6721111	\N	\N	1
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777429	6721112	0.143	0.143	1
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777435	6721112	\N	\N	1
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777425	6721113	\N	\N	1
777427	6721113	0.001891	0.001891	1
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777437	6721113	\N	\N	1
777439	6721113	\N	\N	1
777441	6721113	\N	\N	1
777443	6721113	0.001743	0.001743	1
777445	6721113	0.0005237	5.237E-4	1
777447	6721113	\N	\N	1
777449	6721113	0.001628	0.001628	1
777451	6721113	0.001569	0.001569	1
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777461	6721113	0	0.0	1
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777481	6721113	0	0.0	1
777483	6721113	0.00002978	2.978E-5	1
777485	6721113	\N	\N	1
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777425	6721114	\N	\N	1
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777429	6721114	0.0732	0.0732	1
777431	6721114	0.03	0.03	1
777433	6721114	0.2306	0.2306	1
777435	6721114	\N	\N	1
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777439	6721114	0.0234	0.0234	1
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777425	6721115	0.044	0.044	1
777427	6721115	\N	\N	1
777429	6721115	0.152	0.152	1
777431	6721115	0.048	0.048	1
777433	6721115	0.18	0.18	1
777435	6721115	0.008	0.008	1
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777455	6721115	0.016	0.016	1
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777425	6721116	0.039	0.039	1
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777433	6721116	0.231	0.231	1
777435	6721116	0.024	0.024	1
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777423	6721115	0.408	0.408	2
777423	6721112	0.572	0.572	2
777423	6721113	0.992616	0.9926155	2
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777425	6721118	\N	\N	1
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777477	6721118	\N	\N	1
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777489	6721118	\N	\N	1
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777495	6721118	\N	\N	1
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777427	6721119	0	0.0	1
777429	6721119	\N	\N	1
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777437	6721119	\N	\N	1
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777443	6721119	0.005	0.005	1
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777451	6721119	0	0.0	1
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777455	6721119	\N	\N	1
777457	6721119	\N	\N	1
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777533	6721421	0.649	0.649	2
777533	6721419	0.8544	0.8544	2
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777535	6721427	0.154	0.1540	1
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777565	6721427	0.244	0.2440	1
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777535	6721428	0.169	0.1690	1
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777535	6721429	0.135	0.1350	1
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777533	6721429	0.652	0.652	2
777533	6721427	0.602	0.602	2
777533	6721425	0.821	0.821	2
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777565	6721429	0.213	0.2130	1
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777565	6721431	0.1896	0.1896	1
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777565	6721432	0.2247	0.2247	1
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777535	6721433	0.109	0.1090	1
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777565	6721434	0.2232	0.2232	1
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777539	6721435	0.0007	0.0007	1
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777565	6721435	0.1767	0.1767	1
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777535	6721436	0.1335	0.1335	1
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777563	6721436	\N	\N	1
777565	6721436	0.2205	0.2205	1
777567	6721436	\N	\N	1
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777601	6721436	\N	\N	1
778233	6722382	\N	\N	1
777535	6721437	0.133	0.1330	1
777537	6721437	0	0.0	1
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777559	6721450	\N	\N	1
777561	6721450	\N	\N	1
777563	6721450	\N	\N	1
777565	6721450	\N	\N	1
777567	6721450	\N	\N	1
777569	6721450	\N	\N	1
777571	6721450	\N	\N	1
777573	6721450	\N	\N	1
777575	6721450	\N	\N	1
777577	6721450	\N	\N	1
777579	6721450	\N	\N	1
777581	6721450	\N	\N	1
777583	6721450	\N	\N	1
777585	6721450	\N	\N	1
777587	6721450	\N	\N	1
777589	6721450	\N	\N	1
777591	6721450	\N	\N	1
777593	6721450	\N	\N	1
777595	6721450	\N	\N	1
777597	6721450	\N	\N	1
777599	6721450	\N	\N	1
777531	6721450	\N	\N	1
777601	6721450	\N	\N	1
777535	6721451	0.1116	0.1116	1
777537	6721451	\N	\N	1
777539	6721451	\N	\N	1
777541	6721451	\N	\N	1
777543	6721451	\N	\N	1
777545	6721451	\N	\N	1
777547	6721451	\N	\N	1
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777551	6721451	\N	\N	1
777553	6721451	\N	\N	1
777555	6721451	\N	\N	1
777557	6721451	\N	\N	1
777559	6721451	\N	\N	1
777561	6721451	\N	\N	1
777563	6721451	\N	\N	1
777565	6721451	\N	\N	1
777567	6721451	\N	\N	1
777569	6721451	\N	\N	1
777571	6721451	\N	\N	1
777573	6721451	\N	\N	1
777575	6721451	\N	\N	1
777577	6721451	\N	\N	1
777579	6721451	\N	\N	1
777581	6721451	\N	\N	1
777583	6721451	\N	\N	1
777585	6721451	\N	\N	1
777587	6721451	\N	\N	1
777589	6721451	\N	\N	1
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777531	6721451	\N	\N	1
777601	6721451	\N	\N	1
777535	6721452	0.1312	0.1312	1
777537	6721452	\N	\N	1
777539	6721452	\N	\N	1
777541	6721452	\N	\N	1
777543	6721452	\N	\N	1
777545	6721452	\N	\N	1
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777565	6721452	0.1989	0.1989	1
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777599	6721452	\N	\N	1
777531	6721452	\N	\N	1
777601	6721452	\N	\N	1
