-- Data for Name: file_note; Type: TABLE DATA; Schema: cpic; Owner: -
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COPY cpic.file_note (type, entityid, note, ordinal, version) FROM stdin;
GENE_CDS	ABCG2	The phenotype is used to store an interpretation of the test result. This is a design decision that may differ among sites.	0	1
GENE_CDS	ABCG2	For this example, a priority result is defined as a genetic test result that results in a change in drug, drug dose, or drug monitoring.	1	1
GENE_CDS	ABCG2	The specific wording of the interpretive text may differ among sites.	2	1
FREQUENCY	CACNA1S	For full references see "References" tab.	0	1
TEST_ALERT	RxNorm:704	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:704	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:5095	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:5095	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:36437	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:36437	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:140587	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:140587	Pharmacist, pharmacologist, or a clinician with pharmacogenetic expertise/training.	1	1
TEST_ALERT	RxNorm:5640	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:5640	Pharmacist, pharmacologist, or a clinician with pharmacogenetic expertise/training.	1	1
TEST_ALERT	RxNorm:2049549	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:2049549	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:10638	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:10638	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
ALLELE_DEFINITION	CYP2D6	rsID are RefSNP accession ID number (http://www.ncbi.nlm.nih.gov/snp/).	5	1
ALLELE_DEFINITION	CYP2D6	The CYP2D6*1 allele is characterized by the absence of any sequence variations. Consequently, this allele cannot be identified by a SNP; rather CYP2D6*1 is assigned by default when no SNPs are detected during testing.	6	1
ALLELE_DEFINITION	CYP2D6	The CYP2D6*2 allele is typically characterized by two amino acid changes; both, however also occur in many other CYP2D6 alleles. Therefore, if an allele carries these two SNPs exclusively, it is designated CYP2D6*2. Interrogating for additional SNPs is the only way to distinguish CYP2D6*2 from other alleles (e.g., CYP2D6*17 and *41).	7	1
ALLELE_DEFINITION	CYP2D6	4180G>C is present on many allelic variants including functional and non-functional variants. Specifically, it has been found on some CYP2D6*4 subvariants. While some tests include this SNP, it cannot be utilized to identify an allelic variant with certainty.	8	1
ALLELE_DEFINITION	CYP2D6	An important caveat for all genotyping tests is that the decision to assign an allele a wild-type status is based upon a genotyping test that interrogates only the most common and already- proven sites of functional variation. It is always possible that a novel, previously undiscovered (and therefore un-interrogated) site of variation may confer loss-of-function in an individual, and thus lead to the rare possibility of a non-functional allele being erroneously called as wild-type.	9	1
ALLELE_DEFINITION	CYP2D6	Content is accessed through the PharmVar API. HGVS and 'PharmVar-style' (accessible on the PharmVar website) positions may differ for indels in some instances which is most likely explained by differences in sequence alignments. Also, PharmVar displays single nucleotide insertions as 'ins' while the HGVS display is as duplications or 'dup' if the insertion is the same base as the prior base. The entries in the 'Free Text' field in row 2 reflect the default variant names on the CYP2D6 PharmVar page (https://www.pharmvar.org/gene/CYP2D6). Additional variant coordinates are consistent with the content displayed on the upper section of the 'Variant Positions' window which can be accessed by clicking on the variant of interest on the CYP2D6 PharmVar page.	10	1
ALLELE_DEFINITION	NUDT15	PharmVAR releases new alleles based on received submissions, see https://www.pharmvar.org/gene/NUDT15 for comprehensive haplotype definitions of NUDT15 variant alleles, including sub-alleles, and updated allele information.	0	1
ALLELE_DEFINITION	NUDT15	rsID=RefSNP accession ID number (http://www.ncbi.nlm.nih.gov/snp/)	1	1
ALLELE_DEFINITION	NUDT15	All variants are annotated to the positive DNA strand.	2	1
ALLELE_DEFINITION	NUDT15	rs554405994 was merged into rs869320766 which was merged into rs746071566	3	1
ALLELE_DEFINITION	NUDT15	Content is accessed through the PharmVar API. HGVS and 'PharmVar-style' (accessible on the PharmVar website) positions may differ for indels in some instances which is most likely explained by differences in sequence alignments. Also, PharmVar displays single nucleotide insertions as 'ins' while the HGVS display is as duplications or 'dub' if the insertion is the same base as the prior base.	4	1
ALLELE_FUNCTION_REFERENCE	NAT2	Legacy NAT2 allele nomenclature and functional assignments	2	1
GENE_CDS	CACNA1S	The phenotype is used to store an interpretation of the test result. This is a design decision that may differ among sites.	0	1
GENE_CDS	CACNA1S	For this example, a priority result is defined as a genetic test result that results in a change in drug, drug dose, or drug monitoring.	1	1
GENE_CDS	CACNA1S	The specific wording of the interpretive text may differ among sites.	2	1
FREQUENCY	CYP2B6	For full references see "references" tab.	0	1
FREQUENCY	CYP2B6	Average frequencies based on the reported frequencies in one or multiple studies.	1	1
FREQUENCY	CYP2B6	Based on the PharmGKB biogeographical groups https://www.pharmgkb.org/page/biogeographicalGroups	2	1
FREQUENCY	CYP2B6	See allele definition table (https://www.pharmgkb.org/page/cyp2b6RefMaterials) for allele definitions	3	1
FREQUENCY	CYP2B6	Because CYP2B6*1 is not genotyped directly, all alleles that are negative for a sequence variation are defaulted to a CYP2B6*1 assignment. The inferred frequency for CYP2B6*1 is calculated as: 1 - (sum of averaged variant allele frequencies).	4	1
TEST_ALERT	RxNorm:343047	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:343047	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:5691	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:5691	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:36453	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:36453	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:2348	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:2348	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:2348	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:2348	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:6099	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:6099	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:8687	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:8687	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:8687	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:8687	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:10689	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:10689	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
ALLELE_DEFINITION	CYP3A5	The variants included are based on the PharmVar core alleles (for core alleles only see https://www.pharmvar.org/gene/CYP3a5).	0	1
ALLELE_DEFINITION	CYP3A5	See PharmVar website (http://www.pharmvar.org) for comprehensive haplotype definitions of CYP3A5 variant alleles, including sub-alleles, and updated allele information.	1	1
ALLELE_DEFINITION	CYP3A5	rsID=RefSNP accession ID number (http://www.ncbi.nlm.nih.gov/snp/)	2	1
ALLELE_DEFINITION	CYP3A5	All variants are annotated to the positive DNA strand.	3	1
ALLELE_DEFINITION	CYP3A5	An important caveat for all genotyping tests is that the decision to assign an allele a "wild- type" status is based upon a genotyping test that interrogates only the most common and already-proven sites of functional variation. In human DNA, it is always possible that a new, previously undiscovered (and therefore un-interrogated) site of variation may confer loss-of- function in an individual, and thus lead to the rare possibility of a non-functional allele being erroneously called as "wild-type"	4	1
ALLELE_DEFINITION	CYP3A5	Citations for assignment of function can be found at https://www.pharmgkb.org/page/cyp3a5RefMaterials	5	1
ALLELE_DEFINITION	CYP3A5	Content is accessed through the PharmVar API. HGVS and 'PharmVar-style' (accessible on the PharmVar website) positions may differ for indels in some instances which is most likely explained by differences in sequence alignments. Also, PharmVar displays single nucleotide insertions as 'ins' while the HGVS display is as duplications or 'dub' if the insertion is the same base as the prior base.	6	1
ALLELE_DEFINITION	RYR1	Variant selection based on an update of the CPIC guideline for potent volatile anesthetic agents and succinylcholine. The guideline update includes the published list of RYR1 variants (supplemental table S2), which are evaluated by the ClinGen malignant hyperthermia susceptibility (MHS) variant curation expert panel and classified for RYR1-related malignant hyperthermia susceptibility based on specified the ACMG/AMP criteria (PMID 35849058).	0	1
ALLELE_DEFINITION	RYR1	The deletion of an E can be represented as E2347del orE2348del (c.7039_7041delGAG or c.7042_7044delGAG, respectivly). c.7042_7044delGAG is used to name the variant in the file to reflect the ClinGen naming, however the mapping of the variant is done according to the corresponding rsID rs121918596.	1	1
ALLELE_FUNCTION_REFERENCE	NAT2	PharmVar NAT2 Read Me	3	1
GENE_CDS	CYP2B6	The phenotype is used to store an interpretation of the test result. This is a design decision that may differ among sites.	0	1
GENE_CDS	CYP2B6	For this example, a priority result is defined as a genetic test result that results in a change in drug, drug dose, or drug monitoring.	1	1
GENE_CDS	CYP2B6	The specific wording of the interpretive text may differ among sites.	2	1
GENE_CDS	CYP2B6	Although two CYP2B6 alleles, *4 and *22, are categorized as increased function alleles, the effect of *4 and *22 on CYP2B6 function with respect to efavirenz plasma exposure appears to be modest based on current evidence. However, the phenotype categories of CYP2B6 rapid metabolizer (RM; one normal function allele and one increased function allele) and CYP2B6 ultra-rapid metabolizer (UM; two increased function alleles) were created to allow for the possibility that these may be clinically relevant for CYP2B6 substrates other than efavirenz. As there is no recommendation for altering dosing for CYP2B6 RMs or UMs for efavirenz, the EHR priority is sent to "normal" for these metabolizers.	3	1
FREQUENCY	CYP2C9	For full references see "References" tab.	0	1
FREQUENCY	CYP2C9	Average frequencies based on the reported frequencies in one or multiple studies.	1	1
FREQUENCY	CYP2C9	Based on the PharmGKB biogeographical groups https://www.pharmgkb.org/page/biogeographicalGroups	2	1
FREQUENCY	CYP2C9	See allele definition table (https://www.pharmgkb.org/page/cyp2c9RefMaterials) for allele definitions	3	1
FREQUENCY	CYP2C9	Because CYP2C9*1 is not genotyped directly, all alleles that are negative for a sequence variation are defaulted to a CYP2C9*1 assignment. The inferred frequency for CYP2C9*1 is calculated as: 1 - (sum of averaged variant allele frequencies).	4	1
TEST_ALERT	RxNorm:83367	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:83367	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:6026	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:6026	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:36567	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:36567	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:2393	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:2393	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:2393	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:2393	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:20890	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:20890	Pharmacist, pharmacologist, or a clinician with pharmacogenetic expertise/training.	1	1
TEST_ALERT	RxNorm:9071	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:9071	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:9071	The specific wording of the alert text may differ among sites.	2	1
ALLELE_DEFINITION	CYP4F2	rsID=RefSNP accession ID number (http://www.ncbi.nlm.nih.gov/snp/)	0	1
ALLELE_DEFINITION	CYP4F2	All variants are annotated to the positive DNA strand.	1	1
ALLELE_DEFINITION	CYP4F2	See PharmVar website (http://pharmvar.org) for comprehensive haplotype definitions of CYP4F2 variant alleles and updated allele information.	2	1
ALLELE_DEFINITION	CYP4F2	An important caveat for all genotyping tests is that the decision to assign an allele a "wild-type" status is based upon a genotyping test that interrogates only the most common and already-proven sites of functional variation. In human DNA, it is always possible that a new, previously undiscovered (and therefore un-interrogated) site of variation may confer loss-of-function in an individual, and thus lead to the rare possibility of a non-functional allele being erroneously called as "wild-type."	3	1
ALLELE_DEFINITION	SLCO1B1	rsID=RefSNP accession ID number (http://www.ncbi.nlm.nih.gov/snp/)	0	1
ALLELE_DEFINITION	SLCO1B1	All variants are annotated to the positive DNA strand.	1	1
ALLELE_DEFINITION	SLCO1B1	An important caveat for all genotyping tests is that the decision to assign an allele a "wild-type" status is based upon a genotyping test that interrogates only the most common and already-proven sites of functional variation. In human DNA, it is always possible that a new, previously undiscovered (and therefore un-interrogated) site of variation may confer loss-of-function in an individual, and thus lead to the rare possibility of a non-functional allele being erroneously called as "wild-type."	2	1
ALLELE_DEFINITION	SLCO1B1	Citations for assignment of function can be found at https://www.pharmgkb.org/page/slco1b1RefMaterials	3	1
ALLELE_FUNCTION_REFERENCE	RYR1	Variant selection based on an update of the CPIC guideline for potent volatile anesthetic agents and succinylcholine. The guideline update includes the published list of RYR1 variants (supplemental Table S2), which are evaluated by the ClinGen malignant hyperthermia susceptibility (MHS) variant curation expert panel (VCEP) and classified for RYR1-related malignant hyperthermia susceptibility based on specified ACMG/AMP criteria (PMID 35849058). The entries in the column 'Allele Functional Status (Optional)' are from the 'Pathogenicity' column and the entries in the column 'Findings (Optional)' are from the ACMG/AMP Criteria column in Table S2 (PMID 35849058).	0	1
ALLELE_FUNCTION_REFERENCE	RYR1	Variants 1209C>G, 7522C>G, 14387A>G, 14693T>C are not included in the PMID 35849058 and are classified as VUS by the RYR1 VCEP in May 2023.	1	1
ALLELE_FUNCTION_REFERENCE	RYR1	Variant classification was re-evaluated and updated by the RYR1 VCEP in May 2023 for the following variants: c.488G>T, c.1589G>A, c.7522C>T, c.14210G>A, c.14582G>A, c.6612C>G, c.14918C>T, c.5183C>T, c.5132A>G, c.6838G>A	2	1
ALLELE_FUNCTION_REFERENCE	RYR1	Variant classification was re-evaluated and updated by the RYR1 VCEP in Nov 2023 for the following variants: c.6488G>T, c.14627A>G, c.14813T>C	3	1
ALLELE_FUNCTION_REFERENCE	RYR1	Allele Clinical Functional Status is mapped to the classification by the ClinGen malignant hyperthermia susceptibility (MHS) variant curation expert panel PMID: 35849058 as follows:	4	1
GENE_CDS	CYP2C19	The phenotype is used to store an interpretation of the test result. This is a design decision that may differ among sites.	0	1
GENE_CDS	CYP2C19	For this example, a priority result is defined as a genetic test result that results in a change in drug, drug dose, or drug monitoring.	1	1
GENE_CDS	CYP2C19	The specific wording of the interpretive text may differ among sites.	2	1
FREQUENCY	CYP2D6	In the Sub-Saharan African group, presented data for Twesigomwe et al., 2022 PMID 36111505 is a combination of frequencies from PMID 36111505 and Wang et al. 2022 PMID 36294714. See the Methods and Caveats tab for how *1 frequencies are determined for this file.	0	1
TEST_ALERT	RxNorm:2002	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:2002	"Clinical Pharmacist" could be a pharmacist, pharmacologist, or a clinician with pharmacogenetic expertise/training.	1	1
TEST_ALERT	RxNorm:17128	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:17128	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:17128	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:17128	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:10154	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:10154	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:2551	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:2551	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:2551	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:2551	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:6572	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:6572	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:6572	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:6572	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:9071	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:27392	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:27392	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
ALLELE_DEFINITION	DPYD	Variant selection is based on the CPIC guideline for Fluoropyrimidines and DPYD (https://cpicpgx.org/guidelines/guideline-for-fluoropyrimidines-and-dpyd/) and sourced from PharmVar (https://www.pharmvar.org/gene/DPYD).	0	1
ALLELE_DEFINITION	DPYD	All variants are annotated to the positive DNA strand.	1	1
ALLELE_DEFINITION	DPYD	As an individual only carries a maximum of two fully functional DPYD copies, common normal function variants may be located on the same gene copy as other normal	2	1
ALLELE_DEFINITION	DPYD	c.1129-5923C>G is likely the HapB3 haplotype causal variant. c.1236G>A (E412E) is a proxy SNP for HapB3.	3	1
ALLELE_DEFINITION	TPMT	rsID=RefSNP accession ID number (http://www.ncbi.nlm.nih.gov/snp/)	0	1
GENE_CDS	CYP2C9	The phenotype is used to store an interpretation of the test result. This is a design decision that may differ among sites. Assignment of all Genotype/Phenotype Summaries based on diplotype is available on the 'Possible CYP2C19' Diplotype tab.	0	1
GENE_CDS	CYP2C9	A priority result is defined as a genetic test result that results in a change in drug, drug dose, or drug monitoring.	1	1
GENE_CDS	CYP2C9	The specific wording of the interpretive text may differ among sites.	2	1
FREQUENCY	CYP3A5	For full references see "References" tab.	0	1
FREQUENCY	CYP3A5	Average frequencies based on the reported frequencies in one or multiple studies.	1	1
FREQUENCY	CYP3A5	Based on the PharmGKB biogeographical groups https://www.pharmgkb.org/page/biogeographicalGroups	2	1
FREQUENCY	CYP3A5	See the Allele Definition Table at http://www.pharmgkb.org/cyp3a5RefMaterials for allele definitions	3	1
FREQUENCY	CYP3A5	Because CYP3A5*1 is not genotyped directly, all alleles that are negative for a sequence variation are defaulted to a CYP3A5*1 assignment. The inferred frequency for CYP3A5*1 is calculated as: 1 - (sum of averaged variant allele frequencies).	4	1
TEST_ALERT	RxNorm:2556	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:2556	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:6472	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:6472	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:42316	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:42316	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:2670	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:2670	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:41493	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:41493	Pharmacist, pharmacologist, or a clinician with pharmacogenetic expertise/training.	1	1
TEST_ALERT	RxNorm:283821	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:283821	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:39786	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:39786	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
ALLELE_DEFINITION	DPYD	Individual patients have been reported (PMID 38129972) to carry only one of the two SNPs in the HapB3 haplotype (i.e., c.1236G>A without c.1129-5923C>G), suggesting that the two variants are not in complete linkage disequilibrium. CPIC updated the allele definition to include the c.1129-5923C>G SNP separately as this is likely the causal variant leading to decreased function. CPIC also retained the HapB3 haplotype definition for cases where only the c.1236G>A variant is tested (e.g. whole exome sequencing). While CPIC recommends to directly test the causal SNP if possible, in cases where only c.1236G>A is tested or results are available for, it should be clearly stated in the test report that "decreased function" was inferred by detecting the exonic tag SNP, and disclose that in rare cases, the causal decreased function variant c.1129-5923C>G may not be present despite having this tag SNP.	4	1
ALLELE_DEFINITION	DPYD	c.680+139G>A is not exclusive to HapB3 and therefore not a suitable proxy.	5	1
ALLELE_DEFINITION	DPYD	rsID rs3918290, when combined with rs1801159, makes up DPYD*2B	6	1
ALLELE_DEFINITION	DPYD	rs56293913, rs3790387, rs2811202 are all part of a common haplotype that also encompasses c.496A>G (M166V).	7	1
ALLELE_DEFINITION	DPYD	The rs115632870 variant was found to be in linkage disequilibrium (D'=1) with the decreased function variant rs115232898 (Y186C); the decreased function associated with this variant is likely due to this linkage.	8	1
ALLELE_DEFINITION	DPYD	Content is accessed through the PharmVar API. HGVS and 'PharmVar-style' (accessible on the PharmVar website) positions may differ for indels in some instances which is most likely explained by differences in sequence alignments. Also, PharmVar displays single nucleotide insertions as 'ins' while the HGVS display is as duplications or 'dub' if the insertion is the same base as the prior base.	9	1
ALLELE_DEFINITION	TPMT	All variants are annotated to the positive DNA strand.	1	1
ALLELE_DEFINITION	TPMT	Variants are sourced from the TPMT nomenclature committee (TPMT Alleles), see https://liu.se/en/research/tpmt-nomenclature-committee	2	1
ALLELE_FUNCTION_REFERENCE	RYR1	Pathogenic = Malignant Hyperthermia associated	5	1
ALLELE_FUNCTION_REFERENCE	RYR1	Likely Pathogenic = Malignant Hyperthermia associated	6	1
ALLELE_FUNCTION_REFERENCE	RYR1	Variant of uncertain significance = Uncertain function	7	1
ALLELE_FUNCTION_REFERENCE	RYR1	Likely Benign = Normal function	8	1
ALLELE_FUNCTION_REFERENCE	RYR1	Benign = Normal function	9	1
ALLELE_FUNCTION_REFERENCE	RYR1	"Reference" is included in the CPIC RYR1 allele definition table. Allele Clinical Functional Status is assigned Normal function.	10	1
GENE_CDS	CYP3A5	The coded diplotype/phenotype summary is used to store an interpretation of the test result. This is a design decision that may differ among sites. Assignment of all Genotype/Phenotype Summaries based on diplotype is available on the 'Possible CYP2C19' Diplotype tab.	0	1
GENE_CDS	CYP3A5	For this example, a priority result is defined as a genetic test result that results in a change in drug, drug dose, or drug monitoring.	1	1
GENE_CDS	CYP3A5	The specific wording of the interpretive text may differ among sites.	2	1
FREQUENCY	CYP4F2	For full references see "references" tab.	0	1
FREQUENCY	CYP4F2	Average frequencies based on the reported frequencies in one or multiple studies.	1	1
FREQUENCY	CYP4F2	Based on the PharmGKB biogeographical groups https://www.pharmgkb.org/page/biogeographicalGroups	2	1
FREQUENCY	CYP4F2	See allele definition table (https://www.pharmgkb.org/page/cyp4f2RefMaterials) for allele definitions	3	1
FREQUENCY	CYP4F2	Because CYP4F2*1 is not genotyped directly, all alleles that are negative for a sequence variation are defaulted to a CYP4F2*1 assignment. The inferred frequency for CYP4F2*1 is calculated as: 1 - (sum of averaged variant allele frequencies).	4	1
TEST_ALERT	RxNorm:2597	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:2597	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:6857	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:6857	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:10324	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:10324	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:3108	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:3108	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:103	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:103	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:NA	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:NA	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:1151	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:1151	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:1151	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:1151	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
ALLELE_DEFINITION	G6PD	This modified table of G6PD variants is from PMID:22293322, https://grenada.lumc.nl/LOVD2/MR/home.php?select_db=G6PD, with several additional variants.	0	1
ALLELE_DEFINITION	G6PD	rsID=RefSNP accession ID number (http://www.ncbi.nlm.nih.gov/snp/)	1	1
ALLELE_DEFINITION	G6PD	All variants are annotated to the positive DNA strand.	2	1
ALLELE_DEFINITION	G6PD	Please note; WHO class as reported in PMID:22293322 and Luzzatto, L. & Poggi, V. Glucose-6-Phosphate Dehydrogenase Deficiency In: Nathan and Oski's Hematology of Infancy and Childhood, 7th Edition (ed. Meloni, D., Anderson, A. Authors of the book: Orkin, S.H., Fisher, D.E., Look, A.T., Lux IV, S.E., Ginsburg, D., Nathan, D.G. ) (Saunders, Elsevier., 2009) or individual references. This class may have been assigned based on just clinical\nmanifestations and not enzyme activity level or characterization of the enzyme variant.	3	1
ALLELE_DEFINITION	G6PD	Likely phenotype as referenced in this guideline, based on converting assigned WHO class to 3 phenotypes. "Normal" defined as very mild or no enzyme deficiency (>60% normal enzyme levels); "Deficient" defined as mild to severely deficient (<10-60% normal) enzyme levels; "Deficient with CNSHA" defined as severe G6PD enzyme deficiency (<10% activity) with chronic non-spherocytic hemolytic anemia based on Luzzatto, L. & Poggi, V. Glucose-6-Phosphate Dehydrogenase Deficiency In: Nathan and Oski's Hematology of Infancy and Childhood, 7th Edition (ed. Meloni, D., Anderson, A. Authors of the book: Orkin, S.H., Fisher, D.E., Look, A.T., Lux IV, S.E., Ginsburg, D., Nathan, D.G. ) (Saunders, Elsevier., 2009).	4	1
ALLELE_DEFINITION	UGT1A1	rsID=RefSNP accession ID number (http://www.ncbi.nlm.nih.gov/snp/)	0	1
ALLELE_DEFINITION	UGT1A1	All variants are annotated to the positive DNA strand.	1	1
GENE_CDS	DPYD	The phenotype is used to store an interpretation of the test result. This is a design decision that may differ among sites.	0	1
GENE_CDS	DPYD	For this example, a priority result is defined as a genetic test result that results in a change in drug, drug dose, or drug monitoring.	1	1
GENE_CDS	DPYD	The specific wording of the interpretive text may differ among sites.	2	1
FREQUENCY	DPYD	Both variants in c.1129-5923C>G, c.1236G>A (HapB3) are listed with identical frequencies in 1000 Genomes	0	1
FREQUENCY	DPYD	For full references see "References" tab.	1	1
FREQUENCY	DPYD	Average frequencies based on the reported frequencies in one or multiple studies.	2	1
FREQUENCY	DPYD	Based on the PharmGKB biogeographical groups https://www.pharmgkb.org/page/biogeographicalGroups	3	1
FREQUENCY	DPYD	See allele definition table (https://www.pharmgkb.org/page/dpydRefMaterials) for allele definitions	4	1
TEST_ALERT	RxNorm:32968	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:32968	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:7531	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:7531	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:37790	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:37790	Pharmacist, pharmacologist, or a clinician with pharmacogenetic expertise/training.	1	1
TEST_ALERT	RxNorm:3328	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:3328	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:6878	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:6878	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:10109	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:10109	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:11258	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:11258	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:11258	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:11258	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
DIPLOTYPE_PHENOTYPE	RYR1	The CPIC guideline includes RYR1 variants assigned a Allele Clinical Functional Status of Normal function, Uncertain function, and Malignant Hyperthermia associated (see the "RYR1_allele_functionality_reference" file). A translation of Allele Function combinations to Phenotype is available in the "RYR1_phenotypes" file. It might be possible that a subject could have more than 2 RYR1 variants and this RYR1_Diplotype_Phenotype_Table is a representation of possible RYR1 genotypes considering the two functionally most impacted RYR1 variants.	0	1
GENE_CDS	G6PD	For this example, a priority result is defined as a genetic test result that results in a change in drug, drug dose, or drug monitoring.	0	1
GENE_CDS	G6PD	The specific wording of the interpretive text may differ among sites.	1	1
FREQUENCY	G6PD	The allele frequency table was made by searching the gnomAD database v2.1.1 except for Cairo from v3.1.2	0	1
FREQUENCY	G6PD	Based on the PharmGKB biogeographical groups https://www.pharmgkb.org/page/biogeographicalGroups	1	1
FREQUENCY	G6PD	See allele definition table (https://www.pharmgkb.org/page/g6pdRefMaterials) for allele definitions	2	1
FREQUENCY	G6PD	Because B(reference) is not genotyped directly, all alleles that are negative for a sequence variation are defaulted to a B (reference) assignment. The inferred frequency for B(reference) is calculated as: 1 - (sum of averaged variant allele frequencies) but this may not be accurate since there are many variants with no known frequency.	3	1
FREQUENCY	G6PD	Note that gnomAD does not calculate haploytpe frequencies. Some haplotypes have frequencies in this spreadsheet if a unique allele in the haplotype has frequency information in gnomAD AND if the other variant in the haplotype is known to have normal function	4	1
FREQUENCY	G6PD	Note that some variants in this spreadsheet can either be found alone or in a haplotype (in combination with other variants). Therefore the frequency reported MAY NOT BE FOR THE VARIANT ALONE, BUT ALSO FOR THE VARIANT IF FOUND IN A HAPLOTYPE.	5	1
TEST_ALERT	RxNorm:27340	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:27340	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:7646	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:7646	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:7646	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:7646	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:10834	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:10834	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:3445	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:3445	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:3445	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:3445	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:6918	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:6918	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:10171	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:10171	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:10171	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:10171	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
ALLELE_DEFINITION	IFNL3	rsID=RefSNP accession ID number (http://www.ncbi.nlm.nih.gov/snp/)	0	1
ALLELE_DEFINITION	IFNL3	All variants are annotated to the positive DNA strand.	1	1
ALLELE_DEFINITION	UGT1A1	To see a full list of known UGT1A1 alleles see https://www.pharmacogenomics.pha.ulaval.ca/wp-content/uploads/2015/04/UGT1A1-allele-nomenclature.html	2	1
ALLELE_DEFINITION	UGT1A1	An important caveat for all genotyping tests is that the decision to assign an allele a "wild-type" status is based upon a genotyping test that interrogates only the most common and already- proven sites of functional variation. In human DNA, it is always possible that a new, previously undiscovered (and therefore un-interrogated) site of variation may confer loss-of-function in an individual, and thus lead to the rare possibility of a non-functional allele being erroneously called as "wild-type".	3	1
ALLELE_DEFINITION	UGT1A1	Citations for assignment of function can be found at https://www.pharmgkb.org/page/ugt1a1RefMaterials	4	1
ALLELE_DEFINITION	UGT1A1	UGT1A1*80 is in very high linkage disequilibrium with *28 and *37. However, the function of the *80 allele alone, in the absence of *28 or *37, is uncertain. If a patient is only tested for *80, decreased function may be inferred, though linkage is not 100%.	5	1
ALLELE_DEFINITION	UGT1A1	TA repeat: Historically in the literature and at the UGT nomenclature website, the TA repeat is referred to as TA(6) for *1, TA(7) for *28, TA(5) for *36, etc. The UGT allele nomenclature website (https://www.pharmacogenomics.pha.ulaval.ca/wp-content/uploads/2015/04/UGT1A1-allele-nomenclature.html) defines them in more detail as for example: A(TA)6TAA to A(TA)7TAA for *28 and A(TA)6TAA to A(TA)5TAA for *36. Note that after the repeat and number, there is an additional TA listed in the flanking sequence as "TAA". Similar nomenclature/representation is in cell C2 of the table on the "Alleles" tab as historical referencing ("CA" in front as an anchor for the point in the sequence that the TA repeats are starting from). Rows 4 and 5 align with the indicated reference sequences. In cells C4 and C5, when counting from the first TA at the given position in the sequence and including the last TA, the 5, 6, 7, 8 repeats become 6, 7, 8, 9 because there are actually 6 to 9 "TA" repeats in the genomic and gene reference sequences.	6	1
TEST_ALERT	RxNorm:1455099	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:1455099	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
GENE_CDS	HLA-A	The phenotype is used to store an interpretation of the test result. This is a design decision that may differ among sites.	0	1
GENE_CDS	HLA-A	For this example, a priority result is defined as a genetic test result that results in a change in drug, drug dose, or drug monitoring.	1	1
GENE_CDS	HLA-A	The specific wording of the interpretive text may differ among sites.	2	1
FREQUENCY	HLA-A	For full references see "References" tab.	0	1
FREQUENCY	HLA-A	Average frequencies based on the reported frequencies in one or multiple studies.	1	1
FREQUENCY	HLA-A	Based on the PharmGKB biogeographical groups https://www.pharmgkb.org/page/biogeographicalGroups	2	1
TEST_ALERT	RxNorm:3247	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:3247	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:26225	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:26225	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:121243	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:121243	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:121243	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:121243	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:3639	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:3639	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:3639	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:3639	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:7240	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:7240	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:7240	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:7240	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:10178	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:10178	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:10178	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:10178	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
ALLELE_DEFINITION	MT-RNR1	Variant selection based on the CPIC guideline for aminoglycoside antibiotics and MT-RNR1.	0	1
ALLELE_DEFINITION	VKORC1	rsID=RefSNP accession ID number (http://www.ncbi.nlm.nih.gov/snp/)	0	1
ALLELE_DEFINITION	VKORC1	All variants are annotated to the positive DNA strand.	1	1
GENE_CDS	HLA-B	The phenotype is used to store an interpretation of the test result. This is a design decision that may differ among sites.	0	1
GENE_CDS	HLA-B	For this example, a priority result is defined as a genetic test result that results in a change in drug, drug dose, or drug monitoring.	1	1
GENE_CDS	HLA-B	The specific wording of the interpretive text may differ among sites.	2	1
FREQUENCY	HLA-B	For full references see "References" tab.	0	1
FREQUENCY	HLA-B	aAverage frequencies based on the reported frequencies in one or multiple studies.	1	1
FREQUENCY	HLA-B	bBased on the PharmGKB biogeographical groups https://www.pharmgkb.org/page/biogeographicalGroups	2	1
TEST_ALERT	RxNorm:816346	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:816346	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:816346	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:816346	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:32624	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:32624	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:190521	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:190521	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:4492	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:4492	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:7299	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:7299	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:10831	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:10831	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:10831	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:10831	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
ALLELE_DEFINITION	CACNA1S	Variant selection based on the CPIC guideline for potent volatile anesthetic agents and succinylcholine and RYR1 and CACNA1S.	0	1
ALLELE_DEFINITION	NAT2	rsID = RefSNP accession ID number (http://www.ncbi.nlm.nih.gov/snp/)	0	1
ALLELE_DEFINITION	NAT2	All variants are annotated to the positive DNA strand.	1	1
ALLELE_DEFINITION	NAT2	Structural variants are represented using the PharmVar ID.	2	1
ALLELE_DEFINITION	NAT2	See PharmVar website (http://www.pharmvar.org) for comprehensive haplotype definitions of NAT2 variant alleles and updated allele information.	3	1
ALLELE_DEFINITION	NAT2	An important caveat for all genotyping tests is that the decision to assign an allele a "wild-type" status is based upon a genotyping test that interrogates only the most common and already-proven sites of functional variation. In human DNA, it is always possible that a new, previously undiscovered (and therefore un-interrogated) site of variation may confer loss-of-function in an individual, and thus lead to the rare possibility of a non-functional allele being erroneously called as "wild-type."	4	1
ALLELE_DEFINITION	NAT2	Some drastic changes have been made to NAT2 nomenclature during transition from the original (Database of Arylamine N-Acetyltransferases (NATs)) to the new (https://www.pharmvar.org/gene/NAT2) "star" allele definitions:	5	1
ALLELE_DEFINITION	NAT2	The NAT2 reference allele has now changed: The NG_012246.1 RefSeq differs from X14672.1 (which was used in the past to define star alleles) at the position that corresponds to c.803 (rs1208), where X14672.1 has "A" while NG_012246.1 has "G". Thus, depending on which reference sequence is utilized, this position is reported as either reference or variant. The transition of allele definitions to the NG_012246.1 RefSeq caused "variant switching", meaning that all star alleles which were previously described as having c.803A>G lost this variant, as "G" is now considered reference, while all other star alleles gained c.803G>A, as "A" is now considered variant.	6	1
ALLELE_FUNCTION_REFERENCE	CYP2B6	CYP2B6 functional metabolic effects may be substrate specific (and extrapolations to other substrates may not be reliable).	0	1
GENE_CDS	MT-RNR1	The phenotype is used to store an interpretation of the test result. This is a design decision that may differ among sites.	0	1
GENE_CDS	MT-RNR1	For this example, a priority result is defined as a genetic test result that results in a change in drug, drug dose, or drug monitoring.	1	1
GENE_CDS	MT-RNR1	The specific wording of the interpretive text may differ among sites.	2	1
FREQUENCY	MT-RNR1	For full references see "References" tab.	0	1
FREQUENCY	MT-RNR1	aAverage frequencies based on the reported frequencies in one or multiple studies.	1	1
FREQUENCY	MT-RNR1	bBased on the PharmGKB biogeographical groups https://www.pharmgkb.org/page/biogeographicalGroups	2	1
TEST_ALERT	RxNorm:3638	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:3638	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:40790	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:40790	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:40790	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:40790	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:519	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:519	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:4502	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:4502	Pharmacist, pharmacologist, or a clinician with pharmacogenetic expertise/training.	1	1
TEST_ALERT	RxNorm:7337	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:7337	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:10184	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:10184	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:10184	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:10184	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
ALLELE_DEFINITION	CFTR	rsID=RefSNP accession ID number (http://www.ncbi.nlm.nih.gov/snp/)	0	1
ALLELE_DEFINITION	CFTR	All variants are annotated to the positive chromosomal strand.	1	1
ALLELE_DEFINITION	CFTR	Class is defined in PMID: 20932301.	2	1
ALLELE_DEFINITION	CFTR	Table includes variants listed as ivacaftor responsive on FDA-approved ivacaftor (Kalydeco) label (see change log for updates).	3	1
ALLELE_DEFINITION	CFTR	The ivacaftor (Kalydeco) label includes the CFTR variants as amino acid changes. Based on information in dbSNP, for four variants, the amino acid change can be coded by >1 nucleotide change at the same genomic position. In these cases the variant was named with the protein change and the nucleotide change in parentheses.	4	1
ALLELE_DEFINITION	CFTR	The ivacaftor label includes F311del. The variant is caused by a 3 bp deletion within a repetitive sequence C TTC TTC TTC T at nucleotide position 1059-1069. This results in a deletion of one of the phenylalanine residues at either position 311, 312 or 313.	5	1
GENE_CDS	NAT2	The phenotype is used to store an interpretation of the test result. This is a design decision that may differ among sites.	0	1
GENE_CDS	NAT2	For this example, a priority result is defined as a genetic test result that results in a change in drug, drug dose, or drug monitoring.	1	1
GENE_CDS	NAT2	The specific wording of the interpretive text may differ among sites.	2	1
FREQUENCY	NUDT15	For full references see "References" tab.	0	1
FREQUENCY	NUDT15	Average frequencies based on the reported frequencies in one or multiple studies.	1	1
FREQUENCY	NUDT15	Based on the PharmGKB biogeographical groups https://www.pharmgkb.org/page/biogeographicalGroups	2	1
FREQUENCY	NUDT15	See allele definition table (https://www.pharmgkb.org/page/nudt15RefMaterials) for allele definitions	3	1
FREQUENCY	NUDT15	Because NUDT15*1 is not genotyped directly, all alleles that are negative for a sequence variation are defaulted to a NUDT15*1 assignment. The inferred frequency for NUDT15*1 is calculated as: 1 - (sum of averaged variant allele frequencies).	4	1
TEST_ALERT	RxNorm:195085	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:195085	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:32937	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:32937	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:641	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:641	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:4601	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:4601	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:4601	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:4601	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:7454	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:7454	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:9524	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:9524	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
DIPLOTYPE_PHENOTYPE	DPYD	It is possible that a subject has > 2 DPYD variants and this DPYD_Diplotype_Phenotype_Table is a representation of possible DPYD genotypes considering the two functionally most impacted (lowest activity value) variants. Based on the CPIC guideline for Dihydropyrimidine Dehydrogenase Genotype and Fluoropyrimidine Dosing: 2017 Update (PMID: 29152729), the DPD phenotype is assigned using a gene activity score (DPYD-AS; based on the DPYD Allele Functionality Table), calculated as the sum of the two DPYD variants with the lowest variant activity value. A translation of Allele Function combinations to Phenotype is available in the "DPYD_phenotypes" file. If two decreased/no function variants are present, each decreased/no function variant is considered to be on a different gene copy when the phase is not known.	0	1
TEST_ALERT	RxNorm:9524	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:9524	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
ALLELE_DEFINITION	CFTR	F508C;S1251N includes the following footnote for Table 3 of the FDA-approved ivacaftor label (annotated by ClinPGx 10/05/2023): "Complex/compound mutations where a single allele of the CFTR gene has multiple mutations; these exist independent of the presence of mutations on the other allele."	6	1
ALLELE_DEFINITION	NAT2	The new reference allele is now catalogued as NAT2*1: The sequence of NG_012246.1 RefSeq corresponds to the allele that was formerly described as NAT2*12A. Its renaming as NAT2*1.001 facilitates the application of PharmVar rules to NAT2 allelic nomenclature, while it also enables the use of NAT2*1 name to describe the reference allele, in line with the star allele nomenclature of other pharmacogenes. To avoid confusion during the transition from the legacy to the new nomenclature, *12 is now retired. Having a NAT2*1 allele grouping in place also facilitates NGS analyses using GRCh38 as a reference.	7	1
GENE_CDS	NUDT15	The phenotype is used to store an interpretation of the test result. This is a design decision that may differ among sites.	0	1
GENE_CDS	NUDT15	For this example, a priority result is defined as a genetic test result that results in a change in drug, drug dose, or drug monitoring.	1	1
GENE_CDS	NUDT15	The specific wording of the interpretive text may differ among sites.	2	1
FREQUENCY	RYR1	For full references see "References" tab.	0	1
TEST_ALERT	RxNorm:3920	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:3920	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:8183	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:8183	Pharmacist, pharmacologist, or a clinician with pharmacogenetic expertise/training.	1	1
TEST_ALERT	RxNorm:7833	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:7833	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:7833	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:7833	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	ATC:D06AX07	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	ATC:D06AX07	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:7517	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:7517	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:7517	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:7517	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:10207	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:10207	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:10207	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:10207	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
ALLELE_DEFINITION	CYP2B6	rsID=RefSNP accession ID number (http://www.ncbi.nlm.nih.gov/snp/)	0	1
ALLELE_DEFINITION	CYP2B6	All variants are annotated to the positive chromosomal strand.	1	1
ALLELE_DEFINITION	CYP2B6	See PharmVar website (http://www.pharmvar.org) for comprehensive haplotype definitions of CYP2B6 variant alleles and updated allele information.	2	1
ALLELE_DEFINITION	CYP2B6	An important caveat for all genotyping tests is that the decision to assign an allele a "wild-type" status is based upon a genotyping test that interrogates only the most common and already-proven sites of functional variation. In human DNA, it is always possible that a new, previously undiscovered (and therefore un-interrogated) site of variation may confer loss-of-function in an individual, and thus lead to the rare possibility of a non-functional allele being erroneously called as "wild-type."	3	1
ALLELE_DEFINITION	NAT2	NAT2*4 is no longer considered as the reference allele: Alleles carrying c.803G>A as their only amino acid changing SNV will be called as *4 according to the new nomenclature. This includes the former NAT2*4 reference allele of sequence X14672.1, now considered a variant and listed as NAT2*4.001. Although this will no longer be used as a reference, it is considered to be functionally equivalent to NAT2*1.001 (formerly NAT2*12A) and may still be used to compare the enzymatic or structural properties of polymorphic NAT2 proteins.	8	1
ALLELE_DEFINITION	NAT2	Not all previously defined star alleles have been transferred: In the past, it has not always been clear how a NAT2 haplotype was determined. Many have been inferred via computational phase analysis and were not verified experimentally. In the case of haplotypes where the available evidence from the literature was deemed insufficient to support confident allele definition, those haplotypes were not transferred to PharmVar, but they will remain posted on the original Database of Arylamine N-Acetyltransferases (NATs).	9	1
ALLELE_DEFINITION	NAT2	This file contains the PharmVar NAT2 core allele definitions.	10	1
ALLELE_FUNCTION_REFERENCE	CYP2D6	CNV alleles are based on Table 2 'CYP2D6 Identical Gene Duplications/Multiplications' from the PharmVar CYP2D6 structural variation document (https://a.storyblok.com/f/70677/x/d80b535e9c/cyp2d6_structural-variation_v3-2.pdf).	0	1
GENE_CDS	RYR1	The phenotype is used to store an interpretation of the test result. This is a design decision that may differ among sites.	0	1
GENE_CDS	RYR1	For this example, a priority result is defined as a genetic test result that results in a change in drug, drug dose, or drug monitoring.	1	1
GENE_CDS	RYR1	The specific wording of the interpretive text may differ among sites.	2	1
FREQUENCY	SLCO1B1	For full references see "References" tab.	0	1
FREQUENCY	SLCO1B1	Average frequencies based on the reported frequencies in one or multiple studies.	1	1
FREQUENCY	SLCO1B1	Based on the PharmGKB biogeographical groups https://www.pharmgkb.org/page/biogeographicalGroups	2	1
FREQUENCY	SLCO1B1	See allele definition table (https://www.pharmgkb.org/page/slco1b1RefMaterials) for allele definitions	3	1
FREQUENCY	SLCO1B1	Because SLCO1B1*1 is not genotyped directly, all alleles that are negative for a sequence variation are defaulted to a SLCO1B!*1 assignment. The inferred frequency for SLCO1B1*1 is calculated as: 1 - (sum of averaged variant allele frequencies).	4	1
TEST_ALERT	RxNorm:321988	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:321988	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:8356	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:8356	Pharmacist, pharmacologist, or a clinician with pharmacogenetic expertise/training.	1	1
TEST_ALERT	RxNorm:1191	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:1191	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:1191	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:1191	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:4815	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:4815	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:4815	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:4815	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:7623	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:7623	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:7623	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:7623	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:2054023	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:2054023	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
ALLELE_DEFINITION	CYP2C19	The variants included in the alleles are based on the PharmVar core alleles (for core allele definitions only, see https://www.pharmvar.org/gene/CYP2C19). In addition, variants that present in the core allele for one star allele but also present in some but not allsuballeles of another star allele are included in the other star allele as ambiguous changes using the IUPAC nucleotide code (https://www.bioinformatics.org/sms/iupac.html), e.g. the *4 consensus allele includes a "Y" being either C or T at the -806C>T position since this variant is part of the *17 core allele but is not part of the *4 core allele at PharmVar since it is not present in all *4 suballeles. These postions are represented in grey in the Comparative Allele ViewEr (CAVE) tool at PharmVar.	0	1
ALLELE_DEFINITION	CYP2C19	PharmVAR releases new alleles based on received submissions, see https://www.pharmvar.org for comprehensive haplotype definitions of CYP2C19 variant alleles, including sub-alleles, and updated allele information.	1	1
ALLELE_DEFINITION	CYP2C19	rsID=RefSNP accession ID number (http://www.ncbi.nlm.nih.gov/snp/)	2	1
ALLELE_DEFINITION	CYP2C19	All variants are annotated to the positive DNA strand.	3	1
ALLELE_DEFINITION	CYP2C19	An important caveat for all genotyping tests is that the decision to assign an allele a wild-type status is based upon a genotyping test that interrogates only the most common and already- proven sites of functional variation. It is always possible that a novel, previously undiscovered (and therefore un-interrogated) site of variation may confer loss-of-function in an individual, and thus lead to the rare possibility of a non-functional allele being erroneously called as wild-type.	4	1
ALLELE_DEFINITION	CYP2C19	The deterimental CYP2C19*4-defining SNP (rs28399504) has been identified to be linked (i.e. on the same chromosome) with *17 (-806C>T; rs12248560) in certain ethnic subpopulations. To distinguish the *4 (no function) and *17 (increased function) alleles, both rs28399504 and rs12248560 needs to be genotyped [PMID: 21358751, PMID: 24012947]). This haplotype is designated CYP2C19*4B [PMID: 21716271, PMID: 21358751].	5	1
GENE_CDS	SLCO1B1	The phenotype is used to store an interpretation of the test result. This is a design decision that may differ among sites.	0	1
GENE_CDS	SLCO1B1	For this example, a priority result is defined as a genetic test result that results in a change in drug, drug dose, or drug monitoring.	1	1
GENE_CDS	SLCO1B1	The specific wording of the interpretive text may differ among sites.	2	1
FREQUENCY	TPMT	For full references see "References" tab.	0	1
FREQUENCY	TPMT	Average frequencies based on the reported frequencies in one or multiple studies.	1	1
FREQUENCY	TPMT	Based on the PharmGKB biogeographical groups https://www.pharmgkb.org/page/biogeographicalGroups	2	1
FREQUENCY	TPMT	See the Allele Definition Tables at https://www.pharmgkb.org/page/tpmtRefMaterials for allele definitions	3	1
FREQUENCY	TPMT	Because TPMT*1 is not genotyped directly, all alleles that are negative for a sequence variation are defaulted to a TPMT*1 assignment. The inferred frequency for TPMT*1 is calculated as: 1 - (sum of averaged variant allele frequencies).	4	1
TEST_ALERT	RxNorm:41127	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:41127	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:861634	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:861634	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:38400	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:38400	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:38400	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:38400	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:5470	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:5470	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:7934	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:7934	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:10485	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:10485	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
ALLELE_DEFINITION	CYP2C19	The SNP c.463G>T (rs374036992) has been identified to occur in linkage with the *17-defining SNP (- 806C>T; rs12248560). To distinguish *17 from this haplotype, c.463G>T needs to be genotyped [PMID: 25141895]. This allele has not been submitted to PharmVar for a star allele designation.	6	1
ALLELE_DEFINITION	CYP2C19	CYP2C19*27 was reassigned to CYP2C19*1.006 with PharmVar Version 4.0 Last Updated May 7 2019	7	1
ALLELE_DEFINITION	CYP2C19	CYP2C19*36 is a full gene deletion and *37 is a partial gene deletion that includes at least exon 1; for details see the PharmVar CYP2C19 GeneFocus (PMID 32602114) and the CYP2C19 Structural Variation document at https://www.pharmvar.org/gene/CYP2C19).	8	1
ALLELE_DEFINITION	CYP2C19	CYP2C19*38 was set as reference allele as this allele matches the human genome CYP2C19 Reference sequence LRG_584 / NG_008384.3. The RefSeq (LRG_584 / NG_008384.3) has 80161A while many of star alleles, including all *1 suballeles have 80161G. Thus, the CYP2C19*1 core allele is defined by one amino acid (I331V), while the *38 core allele definition does not have any amino acid changes.	9	1
GENE_CDS	TPMT	The phenotype is used to store an interpretation of the test result. This is a design decision that may differ among sites.	0	1
GENE_CDS	TPMT	For this example, a priority result is defined as a genetic test result that results in a change in drug, drug dose, or drug monitoring.	1	1
GENE_CDS	TPMT	The specific wording of the interpretive text may differ among sites.	2	1
FREQUENCY	UGT1A1	For full references see "References" tab.	0	1
FREQUENCY	UGT1A1	Average frequencies are based on the actual number of subjects with each allele as reported in one or multiple studies.	1	1
FREQUENCY	UGT1A1	Based on the PharmGKB biogeographical groups https://www.pharmgkb.org/page/biogeographicalGroups	2	1
FREQUENCY	UGT1A1	See allele definition table (https://www.pharmgkb.org/page/ugt1a1RefMaterials) for allele definitions	3	1
FREQUENCY	UGT1A1	Because UGT1A1*1 is not genotyped directly, all alleles that are negative for a sequence variation are defaulted to a UGT1A1*1 assignment. The inferred frequency for UGT1A1*1 is calculated as: 1 - (sum of averaged variant allele frequencies).	4	1
TEST_ALERT	RxNorm:42355	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:42355	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:42463	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:42463	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:1256	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:1256	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:5489	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:5489	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:1011650	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:1011650	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:10627	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:10627	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
ALLELE_DEFINITION	CYP2C9	PharmVAR releases new alleles based on received submissions, see https://www.pharmvar.org for comprehensive haplotype definitions of CYP2C9 variant alleles, including sub-alleles, and updated allele information.	0	1
ALLELE_DEFINITION	CYP2C9	rsID=RefSNP accession ID number (http://www.ncbi.nlm.nih.gov/snp/)	1	1
ALLELE_DEFINITION	CYP2C9	All variants are annotated to the positive DNA strand.	2	1
ALLELE_DEFINITION	CYP2C9	An important caveat for all genotyping tests is that the decision to assign an allele a "wild-type" status is based upon a genotyping test that interrogates only the most common and already-proven sites of functional variation. In human DNA, it is always possible that a new, previously undiscovered (and therefore un-interrogated) site of variation may confer loss-of-function in an individual, and thus lead to the rare possibility of a non-functional allele being erroneously called as "wild-type."	3	1
ALLELE_DEFINITION	CYP2C9	Citations for assignment of function can be found at https://www.pharmgkb.org/page/cyp2c9RefMaterials	4	1
ALLELE_DEFINITION	CYP2C9	Content is accessed through the PharmVar API. HGVS and 'PharmVar-style' (accessible on the PharmVar website) positions may differ for indels in some instances which is most likely explained by differences in sequence alignments. Also, PharmVar displays single nucleotide insertions as 'ins' while the HGVS display is as duplications or 'dub' if the insertion is the same base as the prior base.	5	1
ALLELE_DEFINITION	NAT2	Alleles with content annotated in PharmGKB (*5G, *5J, *5M, *5U, *6J, *7G, *17) but not included in PharmVar are added using the the original Database of Arylamine N-Acetyltransferases (NATs, http://nat.mbg.duth.gr/Human%20NAT2%20alleles_2013.htm) definitions. This results in the inclusion of 2 synonymous SNPs (added in grey). PharmVar NAT2 core alleles do not include these SNPs although those are part of many NAT2 suballeles and the cells in the core alleles are therefore left blank in this file (see PharmVar for all transitioned NAT2 suballeles and about what is included in a core allele definition). Additionally, with transitioning to PharmVar, the change at p.268 is now according to the reference sequence R268K (see above information). Therefore, original definitions that include K268R will have a blank cell, while alleles that did not include the SNP will now have an "A" at this position.	11	1
ALLELE_DEFINITION	NAT2	Positions added:	12	1
ALLELE_DEFINITION	NAT2	226T>G part of *7G	13	1
ALLELE_DEFINITION	NAT2	434A>C part of *17	14	1
ALLELE_DEFINITION	NAT2	282C>T and 481C>T synonymous SNPs	15	1
ALLELE_DEFINITION	NAT2	*5G has K268R - 803G =ref at this position, therefore blank	16	1
ALLELE_DEFINITION	NAT2	*5J has 803A	17	1
ALLELE_DEFINITION	NAT2	*5M has K268R - 803G =ref at this position, therefore blank	18	1
ALLELE_DEFINITION	NAT2	*5U has K268R - 803G =ref at this position, therefore blank	19	1
ALLELE_DEFINITION	NAT2	*6J has 803A	20	1
ALLELE_DEFINITION	NAT2	*7G has 803A	21	1
ALLELE_DEFINITION	NAT2	*17 has 803A	22	1
ALLELE_FUNCTION_REFERENCE	NAT2	The NAT gene nomenclature committee has curated, annotated, and assigned function to NAT2 star alleles since 1997. In March 2024, NAT2 nomenclature was transferred to PharmVar with some major changes. Most notably, the creation of NAT2*1 as the reference allele in accordance with the reference genome GRCh38. NAT2*4, the former reference allele, is defined by the presence of the SNV c.803G>A. Historically, acetylation function was assigned to NAT2 * alleles as either "rapid" or "slow". Under the CPIC allele function terminology, rapid acetylation alleles are categorized as "Increased Function" and slow acetylation alleles are categorized as "Decreased Function". More information can be found at the NAT gene nomenclature committee website, including legacy allele nomenclature and functional assignments (see links below). Additionally, see the PharmVar NAT2 Read Me document (link below)	0	1
GENE_CDS	UGT1A1	The phenotype is used to store an interpretation of the test result. This is a design decision that may differ among sites.	0	1
GENE_CDS	UGT1A1	For this example, a priority result is defined as a genetic test result that results in a change in drug, drug dose, or drug monitoring.	1	1
GENE_CDS	UGT1A1	The specific wording of the interpretive text may differ among sites.	2	1
FREQUENCY	VKORC1	For full references see "References" tab.	0	1
FREQUENCY	VKORC1	Average frequencies based on the reported frequencies in one or multiple studies.	1	1
FREQUENCY	VKORC1	Based on the PharmGKB biogeographical groups https://www.pharmgkb.org/page/biogeographicalGroups	2	1
TEST_ALERT	RxNorm:72236	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:72236	Pharmacist, pharmacologist, or a clinician with pharmacogenetic expertise/training.	1	1
TEST_ALERT	RxNorm:301542	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:301542	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:194000	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:194000	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:5521	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:5521	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:5521	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:5521	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:8120	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:8120	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:8120	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:8120	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:10635	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:10635	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:10635	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:10635	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
ALLELE_DEFINITION	CYP2D6	The variants included in the alleles are based on the PharmVar core alleles (for core allele definitions only, see https://www.pharmvar.org/gene/CYP2D6). In addition, variants that present in the core allele for one star allele but also present in some but not all suballeles of another star allele are included in the other star allele as ambiguous changes using the IUPAC nucleotide code (https://www.bioinformatics.org/sms/iupac.html), e.g. the *4 consensus allele includes a "R" being either G or A (positive strand) at the 100C>T (P34S) position since this variant is part of other core star alleles, e.g. *10, but is not part of the *4 core allele at PharmVar since it is not present in all *4 suballeles. These postions are represented in grey (G) in the Comparative Allele ViewEr (CAVE) tool at PharmVar. The g.42129130C>G position is an exception. The SNP by itself causes a synonymous change, therefore by itself the SNP would not be part of a core allele based on the core allele definition. However, in *29 and *70 the SNP is needed for the amino acid change and therefore part of the *29 and *70 core allele definition in PharmVar. To follow the above, "S" is added at the position for star alleles in which not all suballeles carry the SNP. In case all suballeles have the SNP "G" is added.	0	1
ALLELE_DEFINITION	CYP2D6	At PharmVar, information about duplications and gene hybrids are available through https://www.pharmvar.org/gene-support/Variation_CYP2D6.pdf.	1	1
ALLELE_DEFINITION	CYP2D6	PharmVAR releases new alleles based on received submissions, see https://www.pharmvar.org for comprehensive haplotype definitions of CYP2D6 variant alleles, including sub-alleles, and updated allele information.	2	1
ALLELE_DEFINITION	CYP2D6	Amino acid changes are displayed per single variantion. However, in some alleles the 2 consecutive variants together cause a different amino acid change as each by itself. *29, *70: 1660G>A and 1662G>C result in V136I; *82: 1021A>T and 1022C>A result in T107Y; in exon 9 conversion: 4156C>T and 4157A>T result in H478S, 4168G>A and 4169C>G result in A482S	3	1
ALLELE_DEFINITION	CYP2D6	All variants are annotated to the positive DNA strand	4	1
ALLELE_FUNCTION_REFERENCE	NAT2	NAT Gene Nomenclature Committee Homepage	1	1
\.


--
-- Data for Name: flyway_schema_history; Type: TABLE DATA; Schema: cpic; Owner: -
--

COPY cpic.flyway_schema_history (installed_rank, version, description, type, script, checksum, installed_by, installed_on, execution_time, success) FROM stdin;
1	1	Initial bootstrap	SQL	V1__Initial_bootstrap.sql	1343833882	cpic	2020-09-30 21:02:41.398674	17646	t
2	2	initial data	SQL	V2__initial_data.sql	1569953039	cpic	2020-09-30 21:03:00.181244	1464	t
3	3	views	SQL	V3__views.sql	1637573145	cpic	2020-09-30 21:03:02.68466	2906	t
4	4	flow charts	SQL	V4__flow_charts.sql	-461764197	cpic	2020-09-30 21:03:06.637242	3674	t
5	6	nsaid release	SQL	V6__nsaid_release.sql	1899796322	cpic	2020-09-30 21:03:11.349979	2479	t
6	7	nsaid pair data	SQL	V7__nsaid_pair_data.sql	-1759040576	cpic	2020-09-30 21:03:14.862537	1507	t
7	8	data progress view	SQL	V8__data_progress_view.sql	-583739949	cpic	2020-09-30 21:03:17.405314	325	t
8	9	file view	SQL	V9__file_view.sql	-435728782	cpic	2020-09-30 21:03:18.784115	320	t
9	10	pair data update	SQL	V10__pair_data_update.sql	1561416759	cpic	2020-09-30 21:03:20.133162	720	t
10	11	guideline in drug model	SQL	V11__guideline_in_drug_model.sql	1721141764	cpic	2020-09-30 21:03:21.898691	476	t
11	12	pair data update	SQL	V12__pair_data_update.sql	-1970090295	cpic	2020-09-30 21:03:23.402028	233	t
12	13	add publications	SQL	V13__add_publications.sql	1291951866	cpic	2020-09-30 21:03:24.679997	320	t
13	14	add highlighted publications	SQL	V14__add_highlighted_publications.sql	759335679	cpic	2020-09-30 21:03:26.044179	399	t
14	15	pair data update	SQL	V15__pair_data_update.sql	81113836	cpic	2020-09-30 21:03:27.481903	243	t
15	16	update ibuprofen ATC	SQL	V16__update_ibuprofen_ATC.sql	1407599949	cpic	2020-09-30 21:03:28.777477	243	t
16	18	allele status lookup	SQL	V18__allele_status_lookup.sql	-859499970	cpic	2020-09-30 21:03:30.070317	482	t
17	19	new publication	SQL	V19__new_publication.sql	-1342471317	cpic	2020-09-30 21:03:31.581321	315	t
18	20	update sequence IDs	SQL	V20__update_sequence_IDs.sql	-75396910	cpic	2020-09-30 21:03:32.939966	480	t
19	21	recommendation lookup fn	SQL	V21__recommendation_lookup_fn.sql	-1422255981	cpic	2020-09-30 21:03:34.466215	478	t
20	22	ppi release	SQL	V22__ppi_release.sql	-1608844545	cpic	2020-09-30 21:03:35.973984	885	t
21	23	helpful views	SQL	V23__helpful_views.sql	1737227498	cpic	2020-09-30 21:03:37.894656	1362	t
22	24	new drug flowcharts	SQL	V24__new_drug_flowcharts.sql	426101726	cpic	2020-09-30 21:03:40.286768	888	t
23	25	phenytoin guideline update	SQL	V25__phenytoin_guideline_update.sql	-746232628	cpic	2020-09-30 21:03:42.235826	481	t
24	26	validate pair pmids	SQL	V26__validate_pair_pmids.sql	-1806818774	cpic	2020-09-30 21:03:43.755407	240	t
25	27	reference allele	SQL	V27__reference_allele.sql	849245471	cpic	2020-09-30 21:03:45.03582	1701	t
26	\N	apply permissions	SQL	R__apply_permissions.sql	-1445996752	cpic	2020-09-30 21:03:47.781042	1352	t
27	28	more allele frequency	SQL	V28__more_allele_frequency.sql	805701621	cpic	2020-10-06 04:45:31.882019	65	t
28	29	gene notes on diplotype	SQL	V29__gene_notes_on_diplotype.sql	-32272162	cpic	2020-10-06 04:45:31.979835	39	t
29	30	fix diplotype note column name	SQL	V30__fix_diplotype_note_column_name.sql	-1780194441	cpic	2020-10-06 20:33:55.825135	12	t
30	31	structural variant alleles	SQL	V31__structural_variant_alleles.sql	907385290	cpic	2020-10-21 16:33:11.171586	21	t
31	32	more notes	SQL	V32__more_notes.sql	946380705	cpic	2020-10-26 04:13:26.606463	33	t
32	33	remove allele frequency	SQL	V33__remove_allele_frequency.sql	370457724	cpic	2020-10-29 02:34:55.945477	28	t
33	34	add constraints to publication	SQL	V34__add_constraints_to_publication.sql	1822736403	cpic	2020-12-07 19:33:55.270759	86	t
34	35	opioid release	SQL	V35__opioid_release.sql	-334675632	cpic	2021-01-08 00:30:17.865038	51	t
35	36	update allele view	SQL	V36__update_allele_view.sql	-926799802	cpic	2021-01-15 23:54:12.278947	96	t
36	37	remove unused column	SQL	V37__remove_unused column.sql	-2122981860	cpic	2021-03-25 17:42:36.558878	134	t
37	38	gene urls	SQL	V38__gene_urls.sql	1563545318	cpic	2021-03-25 17:42:36.742551	62	t
38	\N	apply permissions	SQL	R__apply_permissions.sql	-575065814	cpic	2021-03-25 17:42:36.82488	28	t
39	39	guideline summary view	SQL	V39__guideline_summary_view.sql	480060255	cpic	2021-03-26 20:19:53.149371	58	t
40	\N	apply permissions	SQL	R__apply_permissions.sql	-1861354715	cpic	2021-03-26 20:19:53.225004	31	t
41	40	fix flowchart urls	SQL	V40__fix_flowchart_urls.sql	-1456884835	cpic	2021-05-11 18:22:43.25079	46	t
43	42	aminoglycosides guideline	SQL	V42__aminoglycosides_guideline.sql	540949488	cpic	2021-06-14 04:40:37.690857	93	t
44	43	seq loc unique key	SQL	V43__seq_loc_unique_key.sql	-1638696174	cpic	2021-06-14 04:40:37.808891	52	t
45	44	functionmethods	SQL	V44__functionmethods.sql	2079604482	cpic	2021-06-29 15:43:53.422219	16	t
46	45	sequence location position	SQL	V45__sequence_location_position.sql	1314277241	cpic	2021-07-09 21:30:29.833003	102	t
47	46	fix dbsnpid column	SQL	V46__fix_dbsnpid_column.sql	-1850897598	cpic	2021-08-05 17:38:43.759722	21	t
48	47	guideline fns	SQL	V47__guideline_fns.sql	-1198346012	cpic	2021-08-18 22:14:26.14922	30	t
49	48	update guideline allele fn	SQL	V48__update_guideline_allele_fn.sql	-1854568090	cpic	2021-09-09 21:03:26.214156	30	t
50	49	fix allele findings	SQL	V49__fix_allele_findings.sql	976892510	cpic	2021-09-09 21:03:26.268771	65	t
51	50	fix IFNL3 lookup	SQL	V50__fix_IFNL3_lookup.sql	119727388	cpic	2021-10-13 17:22:27.82421	9	t
52	51	fix guideline allele fn	SQL	V51__fix_guideline_allele_fn.sql	798068262	cpic	2021-11-10 05:57:09.346894	62	t
53	52	recommendation alleles view	SQL	V52__recommendation_alleles_view.sql	-1879594301	cpic	2021-12-07 15:59:50.932388	98	t
54	\N	apply permissions	SQL	R__apply_permissions.sql	-1576403970	cpic	2021-12-07 15:59:51.080556	20	t
55	53	statins guideline	SQL	V53__statins_guideline.sql	-374639719	cpic	2022-02-16 23:10:42.374259	18	t
56	54	publication index	SQL	V54__publication_index.sql	-1084867310	cpic	2022-02-18 22:16:35.644864	11	t
57	55	allele frequency cache	SQL	V55__allele_frequency_cache.sql	778761699	cpic	2022-03-09 23:20:36.042025	13	t
58	56	gene legacy names	SQL	V56__gene_legacy_names.sql	-442391864	cpic	2022-03-17 23:13:23.411535	13	t
59	57	pgkb recs fn update	SQL	V57__pgkb_recs_fn_update.sql	415609266	cpic	2022-06-10 14:24:09.906199	22	t
42	41	publication files	SQL	V41__publication_files.sql	389573953	cpic	2021-05-11 18:22:43.398622	319	t
60	\N	apply permissions	DELETE	R__apply_permissions.sql	-1576403970	cpic	2022-08-16 07:29:30.595272	0	t
61	58	stats table	SQL	V58__stats_table.sql	1603923816	cpic	2022-08-16 07:35:43.159887	60	t
62	59	remove allele guideline	SQL	V59__remove_allele_guideline.sql	-1144551837	cpic	2022-09-14 17:55:53.477071	21	t
63	60	reference allele	SQL	V60__reference_allele.sql	1296637883	cpic	2022-09-14 17:55:53.52649	26	t
64	61	G6PD guideline prep	SQL	V61__G6PD_guideline_prep.sql	1983975991	cpic	2022-09-14 17:55:53.577532	28	t
65	62	G6PD flow charts	SQL	V62__G6PD_flow_charts.sql	626814934	cpic	2022-09-22 16:42:28.143006	29	t
66	63	fosphenytoin flow chart	SQL	V63__fosphenytoin_flow_chart.sql	1952328724	cpic	2022-09-30 13:34:29.608278	28	t
67	64	recommendation flags	SQL	V64__recommendation_flags.sql	-797174188	cpic	2023-02-27 19:42:13.143746	42	t
68	65	frequency flags	SQL	V65__frequency_flags.sql	-477833361	cpic	2023-03-23 11:54:36.147354	42	t
69	66	ssri snri guideline	SQL	V66__ssri_snri_guideline.sql	-1949888557	cpic	2023-04-12 19:43:47.434594	34	t
70	67	frequency view fix	SQL	V67__frequency_view_fix.sql	-1816979743	cpic	2023-09-01 14:42:15.154823	41	t
71	68	fix function definitions	SQL	V68__fix_function_definitions.sql	1243132888	cpic	2024-01-12 20:33:40.207106	11	t
72	69	change log releases	SQL	V69__change_log_releases.sql	1272931372	cpic	2024-05-09 15:03:57.003783	276	t
73	70	fix allele freq view	SQL	V70__fix_allele_freq_view.sql	-957778206	cpic	2024-10-03 15:13:15.938037	9	t
74	71	fix guideline summary view	SQL	V71__fix_guideline_summary_view.sql	-1334280856	cpic	2025-03-07 16:21:39.906989	8	t
75	72	gene cds changelog	SQL	V72__gene_cds_changelog.sql	1161542228	cpic	2025-08-13 13:08:11.731509	7	t
76	73	clinpgx guideline update	SQL	V73__clinpgx_guideline_update.sql	-1024347267	cpic	2025-08-13 13:08:11.764363	15	t
77	74	supplemental file cleanup	SQL	V74__supplemental_file_cleanup.sql	822347170	cpic	2025-08-21 13:23:06.297301	15	t
78	75	hydrazaline guideline	SQL	V75__hydrazaline_guideline.sql	1311712376	cpic	2025-09-08 15:29:54.084279	6	t
\.


--
-- Data for Name: gene; Type: TABLE DATA; Schema: cpic; Owner: -
--

COPY cpic.gene (symbol, chr, genesequenceid, proteinsequenceid, chromosequenceid, mrnasequenceid, hgncid, ncbiid, ensemblid, pharmgkbid, frequencymethods, lookupmethod, version, notesondiplotype, url, functionmethods, notesonallelenaming, includephenotypefrequencies, includediplotypefrequencies) FROM stdin;
ERCC1	chr19	NG_015839	NP_001974	\N	\N	HGNC:3433	2067	ENSG00000012061	PA155	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
POLG	chr15	NG_008218	NP_002684	\N	\N	HGNC:9179	5428	ENSG00000140521	PA33500	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
ASS1	chr9	NG_011542	NP_000041	\N	\N	HGNC:758	445	ENSG00000130707	PA162376926	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
DRD2	chr11	NG_008841	NP_000786	\N	\N	HGNC:3023	1813	ENSG00000149295	PA27478	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
ATIC	chr2	NG_013002	NP_004035	\N	\N	HGNC:794	471	ENSG00000138363	PA25094	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
APOE	chr19	NG_007084	NP_000032	\N	\N	HGNC:613	348	ENSG00000130203	PA55	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
GSTM1	chr1	NG_009246	NP_000552	\N	\N	HGNC:4632	2944	ENSG00000134184	PA182	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
F5	chr1	NG_011806	NP_000121	\N	\N	HGNC:3542	2153	ENSG00000198734	PA159	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
CYB5R3	chr22	NG_012194	NP_000389	\N	\N	HGNC:2873	1727	ENSG00000100243	PA27331	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
CHRNA3	chr15	NG_016143	NP_000734	\N	\N	HGNC:1957	1136	ENSG00000080644	PA113	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
HMGCR	chr5	NG_011449	NP_000850	\N	\N	HGNC:5006	3156	ENSG00000113161	PA189	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
CRHR1	chr17	NG_009902	NP_004373	\N	\N	HGNC:2357	1394	ENSG00000120088	PA26874	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
ITPA	chr20	NG_012093	NP_258412	\N	\N	HGNC:6176	3704	ENSG00000125877	PA29973	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
MC4R	chr18	NG_016441	NP_005903	\N	\N	HGNC:6932	4160	ENSG00000166603	PA30676	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
COQ2	chr4	NG_015825	NP_056512	\N	\N	HGNC:25223	27235	ENSG00000173085	PA142672084	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
HTR2C	chrX	NG_012082	NP_000859	\N	\N	HGNC:5295	3358	ENSG00000147246	PA194	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
OTC	chrX	NG_008471	NP_000522	\N	\N	HGNC:8512	5009	ENSG00000036473	PA32840	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
MTRR	chr5	NG_008856	NP_002445	\N	\N	HGNC:7473	4552	ENSG00000124275	PA31277	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
LPA	chr6	NG_016147	NP_005568	\N	\N	HGNC:6667	4018	ENSG00000198670	PA30432	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
NAT1	chr8	NG_012245	NP_000653	\N	\N	HGNC:7645	9	ENSG00000171428	PA17	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
CPS1	chr2	NG_008285	NP_001866	\N	\N	HGNC:2323	1373	ENSG00000021826	PA26840	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
EGF	chr4	NG_011441	NP_001954	\N	\N	HGNC:3229	1950	ENSG00000138798	PA27664	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
DYNC2H1	chr11	NG_016423	NP_001368	\N	\N	HGNC:2962	79659	ENSG00000187240	PA27433	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
GNB3	chr12	NG_009100	NP_002066	\N	\N	HGNC:4400	2784	ENSG00000111664	PA176	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
SEMA3C	chr7	\N	NP_006370	\N	\N	HGNC:10725	10512	ENSG00000075223	PA35647	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
KIF6	chr6	\N	NP_659464	\N	\N	HGNC:21202	221458	ENSG00000164627	PA134920075	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
CCHCR1	chr6	\N	NP_061925	\N	\N	HGNC:13930	54535	ENSG00000204536	PA134942738	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
FCGR3A	chr1	NG_009066	NP_000560	\N	\N	HGNC:3619	2214	ENSG00000203747	PA28065	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
NAGS	chr17	NG_008106	NP_694551	\N	\N	HGNC:17996	162417	ENSG00000161653	PA134968729	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
LDLR	chr19	NG_009060	NP_000518	\N	\N	HGNC:6547	3949	ENSG00000130164	PA227	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
ASL	chr7	NG_009288	NP_000039	\N	\N	HGNC:746	435	ENSG00000126522	PA25046	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
HPRT1	chrX	NG_012329	NP_000185	\N	\N	HGNC:5157	3251	ENSG00000165704	PA29427	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
ANKK1	chr11	NG_012976	NP_848605	\N	\N	HGNC:21027	255239	ENSG00000170209	PA134872551	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
XPC	chr3	NG_011763	NP_004619	\N	\N	HGNC:12816	7508	ENSG00000154767	PA37413	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
ADRA2C	\N	\N	\N	\N	\N	HGNC:283	152	ENSG00000184160	PA37	\N	PHENOTYPE	13	\N	https://cpicpgx.org/gene/adra2c/	\N	\N	t	t
CALU	chr7	\N	NP_001210	\N	\N	HGNC:1458	813	ENSG00000128595	PA26047	\N	PHENOTYPE	101	\N	\N	\N	\N	t	t
CES1	chr16	NG_012057	NP_001257	\N	\N	HGNC:1863	1066	ENSG00000198848	PA107	\N	PHENOTYPE	100	\N	\N	\N	\N	t	t
ADRB2	chr5	NG_016421	NP_000015	\N	\N	HGNC:286	154	ENSG00000169252	PA39	\N	PHENOTYPE	3	\N	https://cpicpgx.org/gene/adrb2/	\N	\N	t	t
FKBP5	chr6	NG_012645	NP_004108	\N	\N	HGNC:3721	2289	ENSG00000096060	PA28162	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
ACE	chr17	NG_011648	NP_000780	\N	\N	HGNC:2707	1636	ENSG00000159640	PA139	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
TXNRD2	chr22	NG_011835	NP_006431	\N	\N	HGNC:18155	10587	ENSG00000184470	PA38302	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
GBA	chr1	NG_009783	NP_000148	\N	\N	HGNC:4177	2629	ENSG00000177628	PA28591	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
HLA-DRB1	chr6	NG_002392	NP_002115	\N	\N	HGNC:4948	3123	ENSG00000196126	PA35072	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
CETP	chr16	NG_008952	NP_000069	\N	\N	HGNC:1869	1071	ENSG00000087237	PA108	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
UGT1A4	chr2	NG_002601	NP_009051	\N	\N	HGNC:12536	54657	ENSG00000244474	PA37179	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
TP53	chr17	NG_017013	NP_000537	\N	\N	HGNC:11998	7157	ENSG00000141510	PA36679	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
PRKCA	chr17	NG_012206	NP_002728	\N	\N	HGNC:9393	5578	ENSG00000154229	PA33759	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
TCF7L2	chr10	NG_012631	NP_110383	\N	\N	HGNC:11641	6934	ENSG00000148737	PA36394	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
ADD1	chr4	NG_012037	NP_001110	\N	\N	HGNC:243	118	ENSG00000087274	PA31	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
TMEM43	chr3	NG_008975	NP_077310	\N	\N	HGNC:28472	79188	ENSG00000170876	PA134871907	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
SOD2	chr6	NG_008729	NP_000627	\N	\N	HGNC:11180	6648	ENSG00000112096	PA36017	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
SERPINC1	chr1	NG_012462	NP_000479	\N	\N	HGNC:775	462	ENSG00000117601	PA35026	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
TNF	chr6	NG_007462	NP_000585	\N	\N	HGNC:11892	7124	ENSG00000232810	PA435	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
C11orf65	chr11	\N	NP_689800	\N	\N	HGNC:28519	160140	ENSG00000166323	PA144596484	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
HAS3	chr16	\N	NP_005320	\N	\N	HGNC:4820	3038	ENSG00000103044	PA29196	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
SLC47A2	chr17	\N	NP_001093116	\N	\N	HGNC:26439	146802	ENSG00000180638	PA162403847	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
CBR3	chr21	\N	NP_001227	\N	\N	HGNC:1549	874	ENSG00000159231	PA26122	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
NT5C2	chr10	\N	NP_036361	\N	\N	HGNC:8022	22978	ENSG00000076685	PA31801	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
NEDD4L	chr18	\N	NP_056092	\N	\N	HGNC:7728	23327	ENSG00000049759	PA31534	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
CYB5R1	chr1	\N	NP_057327	\N	\N	HGNC:13397	51706	ENSG00000159348	PA134979668	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
SLC28A3	chr9	\N	NP_071410	\N	\N	HGNC:16484	64078	ENSG00000197506	PA426	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
FDPS	chr1	\N	NP_001995	\N	\N	HGNC:3631	2224	ENSG00000160752	PA28075	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
PTGFR	chr1	\N	NP_000950	\N	\N	HGNC:9600	5737	ENSG00000122420	PA290	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
KCNIP4	chr4	\N	NP_671711	\N	\N	HGNC:30083	80333	ENSG00000185774	PA134893552	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
HLA-DQA1	chr6	\N	NP_002113	\N	\N	HGNC:4942	3117	ENSG00000196735	PA35066	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
ABCC4	chr13	\N	NP_005836	\N	\N	HGNC:55	10257	ENSG00000125257	PA397	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
ABL2	chr1	\N	NP_005149	\N	\N	HGNC:77	27	ENSG00000143322	PA24414	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
UGT2B15	chr4	\N	NP_001067	\N	\N	HGNC:12546	7366	ENSG00000196620	PA37188	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
YEATS4	chr12	\N	NP_006521	\N	\N	HGNC:24859	8089	ENSG00000127337	PA134992686	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
TANC1	chr2	\N	NP_203752	\N	\N	HGNC:29364	85461	ENSG00000115183	PA142670838	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
CRHR2	chr7	\N	NP_001874	\N	\N	HGNC:2358	1395	ENSG00000106113	PA26875	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
CYB5R2	chr11	\N	NP_057313	\N	\N	HGNC:24376	51700	ENSG00000166394	PA142672060	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
XRCC1	chr19	\N	NP_006288	\N	\N	HGNC:12828	7515	ENSG00000073050	PA369	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
COL22A1	chr8	\N	NP_690848	\N	\N	HGNC:22989	169044	ENSG00000169436	PA134914705	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
CYB5R4	chr6	\N	NP_057314	\N	\N	HGNC:20147	51167	ENSG00000065615	PA134904907	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
C8orf34	chr8	\N	NP_443190	\N	\N	HGNC:30905	116328	ENSG00000165084	PA142672353	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
ADORA2A	chr22	\N	NP_000666	\N	\N	HGNC:263	135	ENSG00000128271	PA24584	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
NAT2	chr8	NG_012246.1	NP_000006.2	NC_000008.11	NM_001042351.2	HGNC:7646	10	ENSG00000156006	PA18	\N	PHENOTYPE	102	\N	\N	\N	Common name	t	t
ADRB1	\N	\N	\N	\N	\N	HGNC:285	153	ENSG00000043591	PA38	\N	PHENOTYPE	99	\N	https://cpicpgx.org/gene/adrb1/	\N	\N	t	t
CYP2A7P1	chr19	NG_000008	\N	\N	\N	HGNC:2612	1550	ENSG00000213908	PA27103	\N	PHENOTYPE	101	\N	\N	\N	\N	t	t
FLOT1	chr6	\N	NP_005794	\N	\N	HGNC:3757	10211	ENSG00000137312	PA28175	\N	PHENOTYPE	101	\N	\N	\N	\N	t	t
GRIK4	chr11	\N	NP_055434	\N	\N	HGNC:4582	2900	ENSG00000149403	PA28976	\N	PHENOTYPE	101	\N	\N	\N	\N	t	t
GRK4	\N	\N	\N	\N	\N	HGNC:4543	2868	ENSG00000125388	PA28941	\N	PHENOTYPE	13	\N	https://cpicpgx.org/gene/grk4/	\N	\N	t	t
GRK5	\N	\N	\N	\N	\N	HGNC:4544	2869	ENSG00000198873	PA180	\N	PHENOTYPE	99	\N	https://cpicpgx.org/gene/grk5/	\N	\N	t	t
HLA-C	chr6	NG_002397	NP_002108	\N	\N	HGNC:4933	3107	ENSG00000204525	PA35057	\N	PHENOTYPE	100	\N	\N	\N	\N	t	t
HLA-DPB1	chr6	\N	NP_002112	\N	\N	HGNC:4940	3115	ENSG00000223865	PA35064	\N	PHENOTYPE	101	\N	\N	\N	\N	t	t
HTR1A	chr5	\N	NP_000515	\N	\N	HGNC:5286	3350	ENSG00000178394	PA192	\N	PHENOTYPE	101	\N	\N	\N	\N	t	t
IFNL4	chr19	\N	\N	\N	\N	HGNC:44480	101180976	ENSG00000272395	PA166049147	\N	PHENOTYPE	103	\N	https://cpicpgx.org/gene/ifnl/	\N	\N	t	t
LTC4S	chr5	\N	NP_665874	\N	\N	HGNC:6719	4056	ENSG00000213316	PA235	\N	PHENOTYPE	101	\N	\N	\N	\N	t	t
OPRM1	chr6	NG_021208	NP_000905	\N	\N	HGNC:8156	4988	ENSG00000112038	PA31945	\N	PHENOTYPE	94	\N	https://cpicpgx.org/gene/oprm1/	\N	\N	t	t
PTGS1	chr9	\N	NP_000953	\N	\N	HGNC:9604	5742	ENSG00000095303	PA24346	\N	PHENOTYPE	101	\N	\N	\N	\N	t	t
HLA-A	chr6	NG_002398	NP_002107	\N	\N	HGNC:4931	3105	ENSG00000206503	PA35055	Methods\n\nThe allele frequency table was made by searching the PubMed® database (1995 to September 2019). The following criteria were used for HLA-A: (HLA-A) AND (allele OR frequency). In addition, reports were also identified from citations by others or review articles. Studies were considered for inclusion in the HLA-A frequency table if: (1) the ethnicity of the population was clearly indicated, (2) either allele frequencies or genotype frequencies were reported, (3) the method by which the genes were genotyped was indicated, (4) the sample population consisted of at least 50 individuals with a few exceptions (e.g., smaller cohorts that were part of larger studies) and (5) the study represented an original publication (no reviews or meta-analyses). Allele frequencies reported in phase 3 1000 Genomes (http://browser.1000genomes.org/index.html) and from allelefrequencies.net (https://www.allelefrequencies.net) were also included .\nCaveats to estimated allele frequencies:\n\nSampling. Allele frequencies collected by CPIC for the supplemental tables are based on published literature reports which typically study small groups of people based on a geographic location (e.g. Malaysia, Berlin, Cairo). Almost no studies use genetic markers to estimate ancestry. Manuscripts are often focused on a specific phenotype (e.g. disease) or study only individuals taking a particular drug. Such samples would not be considered a random sample of the general population. Another consideration is that sample size is important, and PGx studies are typically not large. The frequencies collected from these studies are then used to estimate general estimates of entire ethnic population allele frequencies. Therefore, frequencies from larger groups of subjects and frequencies averaged from many sample populations probably result in better estimates.\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details, including the definitions of each group, can be found at https://www.pharmgkb.org/page/biogeographicalGroups. We strongly recommend that users use either the publication or the PharmGKB link provided to familiarize themselves with the grouping system before using these allele frequencies. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.	ALLELE_STATUS	197	\N	https://cpicpgx.org/gene/hla/	\N	\N	f	f
DPYD	chr1	NG_008807.2	NP_000101.2	NC_000001.11	NM_000110.4	HGNC:3012	282617	ENSG00000188641	PA145	Methods:\nThe DPYD frequency table was created using data from ExAC (http://exac.broadinstitute.org/) and the 1000 Genomes project (http://www.ensembl.org/Homo_sapiens/Info/Index).\nThe average allele frequencies by race were calculated by taking the number with the variant in all studies divided by the total number of individuals tested for the variant in all studies.\nAll nucleotide changes are according to reference sequence NM_000110.3 and all protein changes are according to reference sequence NP_000101.2\nCaveats\nIf 1000 Genomes and/or ExAC did not return any frequency data for a given variant, cells were left blank\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details can be found at https://www.pharmgkb.org/page/biogeographicalGroups. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.\n\n\n\n\n\n\n\n	ACTIVITY_SCORE	396	The DPYD phenotype is assigned using a gene activity score (DPYD-AS; based on the DPYD Allele Functionality Table), calculated as the sum of the two DPYD variants with the lowest variant activity value. Briefly, carriers of two no function variants (DPYD-AS: 0) OR one decreased function variant (DPD-AS: 0.5) are classified as DPYD poor metabolizers; carriers of two decreased function variants OR carriers of only one no function variant (DPYD-AS: 1) OR carriers of only one decreased function variant (DPYD-AS: 1.5) are considered DPYD intermediate metabolizers , and those with only normal function variants are classified as DPYD normal metabolizers (DPYD-AS: 2). If two decreased/no function variants are present, each decreased/no function variant is considered to be on a different gene copy. Irrespective of the presence of decreased/no function variants, patients may carry multiple normal function variants. As an individual only carries a maximum of two fully functional DPYD copies, common normal function variants may be located on the same gene copy as other normal function variants or decreased/no function variants.	https://cpicpgx.org/gene/dpyd/	\N	Legacy Name/Class	f	f
NUDT15	chr13	NG_047021.1	NP_060753.1	NC_000013.11	NM_001042351.2	HGNC:23063	55270	ENSG00000136159	PA134963132	The allele frequency table was made by searching the PubMed® database (no start date to 1/2018). Allele frequencies reported in the gnomAD browser (http://gnomad.broadinstitute.org/ - exomes and genomes) and ensembl (grch37.ensembl.org - exomes or genomes) were also included. URLs are included in the "PMID" column.\n\nDiplotype and phenotype frequencies were estimated using the equation describing Hardy Weinberg equilibrium based on reported allele frequencies.\n\nCaveats to estimated allele, diplotype and phenotype frequencies:\n\nSampling. Allele frequencies collected by CPIC for the supplemental tables are based on published literature reports which typically study small groups of people based on a geographic location (e.g. Malaysia, Berlin, Cairo). Almost no studies use genetic markers to estimate ancestry. Manuscripts are often focused on a specific phenotype (e.g. disease) or study only individuals taking a particular drug. Such samples would not be considered a random sample of the general population. Another consideration is that sample size is important, and PGx studies are typically not large. The frequencies collected from these studies are then used to estimate general estimates of entire ethnic population allele frequencies. Therefore, frequencies from larger groups of subjects and frequencies averaged from many sample populations probably result in better estimates.\n\nEstimation of *1 frequency. In general, there are no population studies that test for all known variant alleles. Because *1 is not genotyped directly in many studies, all alleles that are negative for a sequence variation are defaulted to a *1 assignment. The inferred frequency for *1 is estimated as: 100 - (sum of averaged variant allele frequencies). For genes where many alleles are not tested for in any population, and frequency of 'common' alleles is not well documented in many understudied populations (Oceania, South Asian, Latino), the *1 frequency will deviate even more from true values.\n\nDiplotype/Phenotype frequency estimates. Diplotype and phenotype frequencies were estimated using the equation describing Hardy Weinberg equilibrium based on reported allele frequencies. When calculating diplotype frequencies from these allele frequencies, the margin of error is compounded based on the margin of error on each allele in the diplotype. So, the margin of error will necessarily increase for diplotype frequency estimates compared to allele frequency estimates. For allele frequencies with already large margins of error due to small and non-random sampling, the diplotype margin of error could potentially be quite large. On the other hand, for well-studied alleles, the margin of error is likely low.\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details can be found at https://www.pharmgkb.org/page/biogeographicalGroups. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.	PHENOTYPE	387	\N	https://cpicpgx.org/gene/nudt15/	\N	Common name	t	t
RYR1	chr19	NG_008866.1	NP_000531.2	NC_000019.10	NM_000540.2	HGNC:10483	6261	ENSG00000196218	PA34896	Methods\n\nTable includes variants based on an update of the CPIC guideline for potent volatile anesthetic agents and succinylcholine. The guideline update includes the published list of RYR1 variants (supplemental table S2), which are evaluated by the ClinGen malignant hyperthermia susceptibility (MHS) variant curation expert panel and classified for RYR1-related malignant hyperthermia susceptibility based on specified ACMG/AMP criteria (PMID 35849058).\n\ngnomAD v2.1.1 was queried with the variant positions or rsIDs.\ngnomAD population description - PharmGKB biogeographical group mapping:\nAfrican/African American - Sub-Saharan African\nSouth Asian - Central/South Asian\nLatino/Admixed American - Latino\nEast Asian - East Asian\nNon-Finnish European - European\nAshkenazi Jewish - Near Eastern\n\nCaveats to estimated allele, frequencies:\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details, including the definitions of each group, can be found at https://www.pharmgkb.org/page/biogeographicalGroups. We strongly recommend that users use either the publication or the PharmGKB link provided to familiarize themselves with the grouping system before using these allele frequencies. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.	PHENOTYPE	387	\N	https://cpicpgx.org/gene/ryr1/	\N	Common name	f	f
ABCB1	chr7	NG_011513	NP_000918	\N	\N	HGNC:40	5243	ENSG00000085563	PA267	\N	PHENOTYPE	100	\N	\N	\N	\N	t	t
CYP4F2	chr19	NG_007971.2	NP_001073.3	NC_000019.10	NM_000069.2	HGNC:2645	8529	ENSG00000186115	PA27121	Methods\n\nThe allele frequency table was made by searching the PubMed® database (1995 to 2016). Allele frequencies reported in and gnomD browser and phase 3 1000 Genomes were also included (https://gnomad.broadinstitute.org/, http://browser.1000genomes.org/index.html) for alleles that contain single unique variant.\n\nCaveats to estimated allele, diplotype and phenotype frequencies:\n\nSampling. Allele frequencies collected by CPIC for the supplemental tables are based on published literature reports which typically study small groups of people based on a geographic location (e.g. Malaysia, Berlin, Cairo). Almost no studies use genetic markers to estimate ancestry. Manuscripts are often focused on a specific phenotype (e.g. disease) or study only individuals taking a particular drug. Such samples would not be considered a random sample of the general population. Another consideration is that sample size is important, and PGx studies are typically not large. The frequencies collected from these studies are then used to estimate general estimates of entire ethnic population allele frequencies. Therefore, frequencies from larger groups of subjects and frequencies averaged from many sample populations probably result in better estimates.\n\nEstimation of *1 frequency. In general, there are no population studies that test for all known variant alleles. Because *1 is not genotyped directly in many studies, all alleles that are negative for a sequence variation are defaulted to a *1 assignment. Because CYP4F2*1 is not genotyped directly, all alleles that are negative for a sequence variation are defaulted to a CYP4F2*1 assignment. Likewise, sequence variations of alleles that are not tested may default to a CYP4F2*1 assignment and hence contribute to the frequencies reported for this allele. Therefore, the inferred frequency for CYP4F2*1 was calculated as an average from studies describing allele frequencies for the most common alleles found in a particular biogeographical group.\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details can be found at https://www.pharmgkb.org/page/biogeographicalGroups. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.	PHENOTYPE	309	CYP4F2 diplotype to phenotype translation is not applicable to the warfarin guideline.	https://cpicpgx.org/gene/cyp4f2/	\N	Legacy Name/Class	f	f
MT-RNR1	chrM	NG_042193.1	NP_000101.2	NC_012920.1	NM_001042351.2	HGNC:7470	4549	ENSG00000211459	PA31274	Methods\n\nThe allele frequency table was made by searching the PubMed® database (1995 to September 2019). The following criteria were used for MT-RNR1: (Mitochondrial AND (A1555G OR C1494T OR T1095C) AND frequency). In addition, reports were also identified from citations by others or review articles. Studies were considered for inclusion in the MT-RNR1 frequency table if: (1) the ethnicity of the population was clearly indicated, (2) the method by which the genes were genotyped was indicated, (3) the sample population consisted of at least 50 individuals with a few exceptions (e.g., smaller cohorts that were part of larger studies) and (4) the study represented an original publication (no reviews or meta-analyses). Homoplasmic allele frequencies reported in gnomAD (https://gnomad.broadinstitute.org/) were also included .\nCaveats to estimated allele, diplotype and phenotype frequencies:\n\nSampling. Allele frequencies collected by CPIC for the supplemental tables are based on published literature reports which typically study small groups of people based on a geographic location (e.g. Malaysia, Berlin, Cairo). Almost no studies use genetic markers to estimate ancestry. Manuscripts are often focused on a specific phenotype (e.g. disease) or study only individuals taking a particular drug. Such samples would not be considered a random sample of the general population. Another consideration is that sample size is important, and PGx studies are typically not large. The frequencies collected from these studies are then used to estimate general estimates of entire ethnic population allele frequencies. Therefore, frequencies from larger groups of subjects and frequencies averaged from many sample populations probably result in better estimates.\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details, including the definitions of each group, can be found at https://www.pharmgkb.org/page/biogeographicalGroups. We strongly recommend that users use either the publication or the PharmGKB link provided to familiarize themselves with the grouping system before using these allele frequencies. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.	PHENOTYPE	351	\N	https://cpicpgx.org/gene/mt-rnr1/	\N	Common name	f	f
ABCG2	chr4	NG_032067.2	NP_001335914.1	NC_000004.12	NM_004827.3	HGNC:74	9429	ENSG00000118777	PA390	Methods\n\nThe allele frequency table was made by searching the Genome Aggregation Database (gnomAD) and 1000 Genomes phase 3 data by rsID. In addition, pubmed were also searched to include frequencies for certain biogeographical groups (eg. Oceanian and American).\n\nCaveats to estimated allele, frequencies:\n\nSampling. Allele frequencies collected by CPIC for the supplemental tables are based on published literature reports which typically study small groups of people based on a geographic location (e.g. Malaysia, Berlin, Cairo). Almost no studies use genetic markers to estimate ancestry. Manuscripts are often focused on a specific phenotype (e.g. disease) or study only individuals taking a particular drug. Such samples would not be considered a random sample of the general population. Another consideration is that sample size is important, and PGx studies are typically not large. The frequencies collected from these studies are then used to estimate general estimates of entire ethnic population allele frequencies. Therefore, frequencies from larger groups of subjects and frequencies averaged from many sample populations probably result in better estimates.\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details, including the definitions of each group, can be found at https://www.pharmgkb.org/page/biogeographicalGroups. We strongly recommend that users use either the publication or the PharmGKB link provided to familiarize themselves with the grouping system before using these allele frequencies. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.	PHENOTYPE	294	\N	https://cpicpgx.org/gene/abcg2/	\N	\N	t	t
BCHE	chr3	NG_009031	NP_000046	\N	\N	HGNC:983	590	ENSG00000114200	PA25294	\N	PHENOTYPE	100	\N	\N	\N	\N	t	t
TYMS	chr18	\N	NP_001062	\N	\N	HGNC:12441	7298	ENSG00000176890	PA359	\N	PHENOTYPE	101	\N	\N	\N	\N	t	t
CFTR	chr7	NG_016465.4	NP_000483.3	NC_000007.14	NM_000069.2	HGNC:1884	1080	ENSG00000001626	PA109	\N	PHENOTYPE	296	\N	https://cpicpgx.org/gene/cftr/	\N	Legacy Name/Class	t	t
ACYP2	\N	\N	\N	\N	\N	HGNC:180	98	ENSG00000170634	PA24500	\N	PHENOTYPE	74	\N	\N	\N	\N	t	t
UMPS	chr3	NG_017037	NP_000364	\N	\N	HGNC:12563	7372	ENSG00000114491	PA363	\N	PHENOTYPE	100	\N	\N	\N	\N	t	t
UGT1A1	chr2	NG_002601.2	NP_000454.1	NC_000002.12	NM_000540.2	HGNC:12530	54658	ENSG00000241635	PA420	Methods\n\nThe allele frequency table was made by searching the PubMed® database (1995 to 2015). Allele frequencies reported in phase 3 1000 Genomes were also included (http://browser.1000genomes.org/index.html).\n\nCaveats to estimated allele, diplotype and phenotype frequencies:\n\nSampling. Allele frequencies collected by CPIC for the supplemental tables are based on published literature reports which typically study small groups of people based on a geographic location (e.g. Malaysia, Berlin, Cairo). Almost no studies use genetic markers to estimate ancestry. Manuscripts are often focused on a specific phenotype (e.g. disease) or study only individuals taking a particular drug. Such samples would not be considered a random sample of the general population. Another consideration is that sample size is important, and PGx studies are typically not large. The frequencies collected from these studies are then used to estimate general estimates of entire ethnic population allele frequencies. Therefore, frequencies from larger groups of subjects and frequencies averaged from many sample populations probably result in better estimates.\n\nEstimation of *1 frequency. In general, there are no population studies that test for all known variant alleles. Because *1 is not genotyped directly in many studies, all alleles that are negative for a sequence variation are defaulted to a *1 assignment. Because UGT1A1*1 is not genotyped directly, all alleles that are negative for a sequence variation are defaulted to a UGT1A1*1 assignment. Likewise, sequence variations of alleles that are not tested may default to a UGT1A1*1 assignment and hence contribute to the frequencies reported for this allele. Therefore, the inferred frequency for UGT1A1*1 was calculated as an average from studies describing allele frequencies for the most common alleles found in a particular biogeographical group.\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details can be found at https://www.pharmgkb.org/page/biogeographicalGroups. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.	PHENOTYPE	387	\N	https://cpicpgx.org/gene/ugt1a1/	\N	Nucleotide changes from the UGT nomenclature page: https://www.pharmacogenomics.pha.ulaval.ca/wp-content/uploads/2015/04/UGT1A1-allele-nomenclature.html	f	f
CYP2C9	chr10	NG_008385.2	NP_000762.2	NC_000010.11	NM_000069.2	HGNC:2623	1559	ENSG00000138109	PA126	Methods\n\nThe allele frequency table was made by searching the PubMed® database (1995 to July 2019). The following criteria were used for CYP2C9: (CYP2C9 or 2C9 or cytochrome P4502C9) AND (genotype OR allele OR frequency OR minor allele OR variant OR ethnic OR race OR racial OR ethnicity OR population) with filter limits set to retrieve "full-text" and "English" literature. In addition, reports were also identified from citations by others or review articles. Studies were considered for inclusion in the CYP2C9 frequency table if: (1) the ethnicity of the population was clearly indicated, (2) either allele frequencies or genotype frequencies were reported, (3) the method by which the genes were genotyped was indicated, (4) the sample population consisted of at least 50 individuals with a few exceptions (e.g., smaller cohorts that were part of larger studies) and (5) the study represented an original publication (no reviews or meta-analyses). Allele frequencies reported in and gnomD browser and phase 3 1000 Genomes were also included (https://gnomad.broadinstitute.org/, http://browser.1000genomes.org/index.html) for alleles that contain single unique variant.\n\nDiplotype and Phenotype Calculations. Diplotype and phenotype frequencies were estimated using the equation describing Hardy Weinberg equilibrium based on reported allele frequencies.\n\nCaveats to estimated allele, diplotype and phenotype frequencies:\n\nSampling. Allele frequencies collected by CPIC for the supplemental tables are based on published literature reports which typically study small groups of people based on a geographic location (e.g. Malaysia, Berlin, Cairo). Almost no studies use genetic markers to estimate ancestry. Manuscripts are often focused on a specific phenotype (e.g. disease) or study only individuals taking a particular drug. Such samples would not be considered a random sample of the general population. Another consideration is that sample size is important, and PGx studies are typically not large. The frequencies collected from these studies are then used to estimate general estimates of entire ethnic population allele frequencies. Therefore, frequencies from larger groups of subjects and frequencies averaged from many sample populations probably result in better estimates.\n\nEstimation of *1 frequency. In general, there are no population studies that test for all known variant alleles. Because *1 is not genotyped directly in many studies, all alleles that are negative for a sequence variation are defaulted to a *1 assignment. Because CYP2C9*1 is not genotyped directly, all alleles that are negative for a sequence variation are defaulted to a CYP2C9*1 assignment. Likewise, sequence variations of alleles that are not tested may default to a CYP2C9*1 assignment and hence contribute to the frequencies reported for this allele. Therefore, the inferred frequency for CYP2C9*1 was calculated as an average from studies describing allele frequencies for the most common alleles found in a particular biogeographical group.\n\nDiplotype/Phenotype frequency estimates. When calculating diplotype frequencies from these allele frequencies, the margin of error is compounded based on the margin of error on each allele in the diplotype. So, the margin of error will necessarily increase for diplotype frequency estimates compared to allele frequency estimates. For allele frequencies with already large margins of error due to small and non-random sampling, the diplotype margin of error could potentially be quite large. On the other hand, for well-studied alleles, the margin of error is likely low.\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details can be found at https://www.pharmgkb.org/page/biogeographicalGroups. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.	ACTIVITY_SCORE	398	CYP2C9 diplotype to phenotype translation is not applicable to the warfarin guideline.	https://cpicpgx.org/gene/cyp2c9/	Methods:\nThe PubMed and PharmGKB databases were searched for the following keywords: (CYP2C9 OR cytochrome p450 2c9)AND [genomic identifiers (e.g. dbSNP rs number, star alleles, additional common names)] AND English [Language]. Study inclusion criteria included publications that incorporated analyses for the association between CYP2C9 genotype and drug pharmacokinetic parameters, clinical outcomes, or allele function.	Legacy Name/Class	t	t
VDR	chr12	NG_008731	NP_000367	\N	\N	HGNC:12679	7421	ENSG00000111424	PA37301	\N	PHENOTYPE	100	\N	\N	\N	\N	t	t
CYP2D6	chr22	NG_008376.4	NP_000097.3	NC_000022.11	NM_000069.2	HGNC:2625	1565	ENSG00000100197	PA128	Methods:\n\nThe CYP2D6 allele frequency tables (CYP2D6 frequency table; link to PharmGKB) are updates of those previously published in CPIC guidelines (PMID: 25974703, 24458010). Updates to the CYP2D6 allele frequency tables were made by searching the PubMed® database (1995 to 2018). The following criteria were used for CYP2D6: (CYP2D6 or 2D6 or cytochrome P4502D6) AND (genotype OR allele OR frequency OR minor allele OR variant OR ethnic OR race OR racial OR ethnicity) with filter limits set to retrieve "full-text" and "English" literature. In addition, reports were also identified from citations by others or review articles. Studies were considered for inclusion in the CYP2D6 frequency table if: (1) the ethnicity of the population was clearly indicated, (2) either allele frequencies or genotype frequencies were reported, (3) the method by which the genes were genotyped was indicated, (4) the sample population consisted of at least 50 individuals with a few exceptions (e.g., smaller cohorts that were part of larger studies) and (5) the study represented an original publication (no reviews or meta-analyses).\nDiplotype and phenotype frequencies were estimated using the equation describing Hardy Weinberg equilibrium based on reported allele frequencies. Because the frequencies for each allele are averages from all studies for that population, allele frequencies may not add up to100%. To account for this in diplotype and phenotype frequencies calculations, *1 frequency was calculated as 1 - sum (non *1 allele frequency).\n\n\nCaveats to estimated allele, diplotype and phenotype frequencies:\n\nSampling. Allele frequencies collected by CPIC for the supplemental tables are based on published literature reports which typically study small groups of people based on a geographic location (e.g. Malaysia, Berlin, Cairo). Almost no studies use genetic markers to estimate ancestry. Manuscripts are often focused on a specific phenotype (e.g. disease) or study only individuals taking a particular drug. Such samples would not be considered a random sample of the general population. Another consideration is that sample size is important, and PGx studies are typically not large. The frequencies collected from these studies are then used to estimate general estimates of entire ethnic population allele frequencies. Therefore, frequencies from larger groups of subjects and frequencies averaged from many sample populations probably result in better estimates.\n\nEstimation of *1 frequency. In general, there are no population studies that test for all known variant alleles. Because CYP2D6*1 is not genotyped directly, all alleles that are negative for a sequence variation are defaulted to a CYP2D6*1 assignment. Likewise, sequence variations of alleles that are not tested may default to a CYP2D6*1 assignment and hence contribute to the frequencies reported for this allele. Therefore, the inferred frequency for CYP2D6*1 was calculated as an average from studies describing allele frequencies for the most common alleles found in a particular ethnic group.\n\nDiplotype/Phenotype frequency estimates. When calculating diplotype frequencies from these allele frequencies, the margin of error is compounded based on the margin of error on each allele in the diplotype. So, the margin of error will necessarily increase for diplotype frequency estimates compared to allele frequency estimates. For allele frequencies with already large margins of error due to small and non-random sampling, the diplotype margin of error could potentially be quite large. On the other hand, for well-studied alleles, the margin of error is likely low.\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details, including the definitions of each group, can be found at https://www.pharmgkb.org/page/biogeographicalGroups. We strongly recommend that users use either the publication or the PharmGKB link provided to familiarize themselves with the grouping system before using these allele frequencies. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.\n\nOverestimation of allele frequencies. CYP2D6*2 is a 'default' assignment and, unless tested and discriminated for CYP2D6*8, *11, *17, *35,*41 and other variants, will default to a CYP2D6*2 assignment. The frequencies shown here may therefore be over-estimated. CYP2D6*10 is a 'default' assignment and, unless tested and discriminated for, CYP2D6*14 and *36 and other variants, will default to a CYP2D6*10 assignment. The frequencies shown here may therefore be over-estimated. CYP2D6*17 is a 'default' assignment and, unless tested and discriminated for, CYP2D6*40 and *58 will default to a CYP2D6*17 assignment. The frequencies shown here may therefore be over-estimated. CYP2D6*41 has not consistently been determined by its defining SNP (2988G>A) across studies; some platforms still use the -1584C>G SNP to discriminate between CYP2D6*2 and *41. This may lead to an overestimation of the CYP2D6*41 frequency, especially in those of African ancestry.\n\nCNV alleles. Many studies do not specify the exact copy number of duplicated alleles found in their study population and instead report the total frequency of observed CNVs as "xN". Where possible, these frequencies have been included in the CNV column for that allele (e.g. *1xN frequencies are included in the *1x2 column, *4xN frequencies are included in the *4x2 column). Users should be aware that this will lead to an overestimation of the frequency of that exact copy number in the population.	ACTIVITY_SCORE	393	\N	https://cpicpgx.org/gene/cyp2d6/	\N	Legacy Name/Class	t	t
HLA-B	chr6	NG_002397	NP_005505	\N	\N	HGNC:4932	3106	ENSG00000234745	PA35056	Methods\n\nThe allele frequency table was made by searching the PubMed® database (1995 to September 2019). The following criteria were used for HLA-B: (HLA-B) AND (allele OR frequency). In addition, reports were also identified from citations by others or review articles. Studies were considered for inclusion in the HLA-B frequency table if: (1) the ethnicity of the population was clearly indicated, (2) either allele frequencies or genotype frequencies were reported, (3) the method by which the genes were genotyped was indicated, (4) the sample population consisted of at least 50 individuals with a few exceptions (e.g., smaller cohorts that were part of larger studies) and (5) the study represented an original publication (no reviews or meta-analyses). Allele frequencies reported in phase 3 1000 Genomes (http://browser.1000genomes.org/index.html) and from allelefrequencies.net (https://www.allelefrequencies.net) were also included .\nCaveats to estimated allele, diplotype and phenotype frequencies:\n\nSampling. Allele frequencies collected by CPIC for the supplemental tables are based on published literature reports which typically study small groups of people based on a geographic location (e.g. Malaysia, Berlin, Cairo). Almost no studies use genetic markers to estimate ancestry. Manuscripts are often focused on a specific phenotype (e.g. disease) or study only individuals taking a particular drug. Such samples would not be considered a random sample of the general population. Another consideration is that sample size is important, and PGx studies are typically not large. The frequencies collected from these studies are then used to estimate general estimates of entire ethnic population allele frequencies. Therefore, frequencies from larger groups of subjects and frequencies averaged from many sample populations probably result in better estimates.\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details, including the definitions of each group, can be found at https://www.pharmgkb.org/page/biogeographicalGroups. We strongly recommend that users use either the publication or the PharmGKB link provided to familiarize themselves with the grouping system before using these allele frequencies. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.	ALLELE_STATUS	197	\N	https://cpicpgx.org/gene/hla/	\N	\N	f	f
COMT	chr22	NG_011526	NP_000745	\N	\N	HGNC:2228	1312	ENSG00000093010	PA117	\N	PHENOTYPE	94	\N	https://cpicpgx.org/gene/comt/	\N	\N	t	t
CYP2C8	chr10	NG_007972	NP_000761	\N	\N	HGNC:2622	1558	ENSG00000138115	PA125	\N	PHENOTYPE	100	\N	\N	\N	\N	t	t
CYP3A4	chr7	NG_000004	NP_059488	\N	\N	HGNC:2637	1576	ENSG00000160868	PA130	\N	PHENOTYPE	100	\N	\N	\N	\N	t	t
EPHX1	chr1	NG_009776	NP_000111	\N	\N	HGNC:3401	2052	ENSG00000143819	PA27829	\N	PHENOTYPE	100	\N	\N	\N	\N	t	t
GGCX	chr2	NG_011811	NP_000812	\N	\N	HGNC:4247	2677	ENSG00000115486	PA28660	\N	PHENOTYPE	100	\N	\N	\N	\N	t	t
GP1BA	chr17	NG_008767	NP_000164	\N	\N	HGNC:4439	2811	ENSG00000185245	PA178	\N	PHENOTYPE	100	\N	\N	\N	\N	t	t
GSTP1	chr11	NG_012075	NP_000843	\N	\N	HGNC:4638	2950	ENSG00000084207	PA29028	\N	PHENOTYPE	100	\N	\N	\N	\N	t	t
HTR2A	chr13	NG_013011	NP_000612	\N	\N	HGNC:5293	3356	ENSG00000102468	PA193	\N	PHENOTYPE	100	\N	\N	\N	\N	t	t
MTHFR	chr1	NG_013351	NP_005948	\N	\N	HGNC:7436	4524	ENSG00000177000	PA245	\N	PHENOTYPE	100	\N	\N	\N	\N	t	t
NQO1	chr16	NG_011504	NP_000894	\N	\N	HGNC:2874	1728	ENSG00000181019	PA31744	\N	PHENOTYPE	100	\N	\N	\N	\N	t	t
PROC	chr2	NG_016323	NP_000303	\N	\N	HGNC:9451	5624	ENSG00000115718	PA33799	\N	PHENOTYPE	100	\N	\N	\N	\N	t	t
PROS1	chr3	NG_009813	NP_000304	\N	\N	HGNC:9456	5627	ENSG00000184500	PA33809	\N	PHENOTYPE	100	\N	\N	\N	\N	t	t
SCN1A	chr2	NG_011906	NP_008851	\N	\N	HGNC:10585	6323	ENSG00000144285	PA301	\N	PHENOTYPE	100	\N	\N	\N	\N	t	t
SLC6A4	chr17	NG_011747	NP_001036	\N	\N	HGNC:11050	6532	ENSG00000108576	PA312	\N	PHENOTYPE	100	\N	\N	\N	\N	t	t
SLCO1B1	chr12	NG_011745.1	NP_006437.3	NC_000012.12	NM_000540.2	HGNC:10959	10599	ENSG00000134538	PA134865839	Methods\n\nThe allele frequency table was made by searching the PubMed® database (1995 to 2021).\n\nCaveats to estimated allele frequencies:\n\nSampling. Allele frequencies collected by CPIC for the supplemental tables are based on published literature reports which typically study small groups of people based on a geographic location (e.g. Malaysia, Berlin, Cairo). Almost no studies use genetic markers to estimate ancestry. Manuscripts are often focused on a specific phenotype (e.g. disease) or study only individuals taking a particular drug. Such samples would not be considered a random sample of the general population. Another consideration is that sample size is important, and PGx studies are typically not large. The frequencies collected from these studies are then used to estimate general estimates of entire ethnic population allele frequencies. Therefore, frequencies from larger groups of subjects and frequencies averaged from many sample populations probably result in better estimates.\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details can be found at https://www.pharmgkb.org/page/biogeographicalGroups. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.	PHENOTYPE	385	\N	https://cpicpgx.org/gene/slco1b1/	\N	Common name	t	t
CYP3A5	chr7	NG_007938.2	NP_000768.1	NC_000007.14	NM_000069.2	HGNC:2638	1577	ENSG00000106258	PA131	Methods\n\nThe allele frequency table was made by searching the PubMed® database (1995 to 2014).\n\nDiplotype and Phenotype Calculations. Diplotype and phenotype frequencies were estimated using the equation describing Hardy Weinberg equilibrium based on reported allele frequencies.\n\nCaveats to estimated allele frequencies:\n\nSampling. Allele frequencies collected by CPIC for the supplemental tables are based on published literature reports which typically study small groups of people based on a geographic location (e.g. Malaysia, Berlin, Cairo). Almost no studies use genetic markers to estimate ancestry. Manuscripts are often focused on a specific phenotype (e.g. disease) or study only individuals taking a particular drug. Such samples would not be considered a random sample of the general population. Another consideration is that sample size is important, and PGx studies are typically not large. The frequencies collected from these studies are then used to estimate general estimates of entire ethnic population allele frequencies. Therefore, frequencies from larger groups of subjects and frequencies averaged from many sample populations probably result in better estimates.\n\nEstimation of *1 frequency. In general, there are no population studies that test for all known variant alleles. Because *1 is not genotyped directly in many studies, all alleles that are negative for a sequence variation are defaulted to a *1 assignment. Because CYP3A5*1 is not genotyped directly, all alleles that are negative for a sequence variation are defaulted to a CYP3A5*1 assignment. Likewise, sequence variations of alleles that are not tested may default to a CYP3A5*1 assignment and hence contribute to the frequencies reported for this allele. Therefore, the inferred frequency for CYP3A5*1 was calculated as an average from studies describing allele frequencies for the most common alleles found in a particular biogeographical group.\n\nDiplotype/Phenotype frequency estimates. Diplotype and phenotype frequencies were estimated using the equation describing Hardy Weinberg equilibrium based on reported allele frequencies. When calculating diplotype frequencies from these allele frequencies, the margin of error is compounded based on the margin of error on each allele in the diplotype. So, the margin of error will necessarily increase for diplotype frequency estimates compared to allele frequency estimates. For allele frequencies with already large margins of error due to small and non-random sampling, the diplotype margin of error could potentially be quite large. On the other hand, for well-studied alleles, the margin of error is likely low.\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details, including the definitions of each group, can be found at https://www.pharmgkb.org/page/biogeographicalGroups. We strongly recommend that users use either the publication or the PharmGKB link provided to familiarize themselves with the grouping system before using these allele frequencies. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.\n	PHENOTYPE	392	\N	https://cpicpgx.org/gene/cyp3a5/	\N	Legacy Name/Class	t	t
CYP2C19	chr10	NG_008384.3	NP_000760.1	NC_000010.11	NM_000069.2	HGNC:2621	1557	ENSG00000165841	PA124	Methods:\nThe CYP2C19 frequency table includes updates of those previously published in CPIC guidelines. Updates to the CYP2C19 frequency tables were made by searching the PubMed® database (1995 to 2015). The following criteria were used for CYP2C19: (CYP2C19 or 2C19 or cytochrome P4502C19) AND (genotype OR allele OR frequency OR minor allele OR variant OR ethnic OR race OR racial OR ethnicity) with filter limits set to retrieve "full-text" and "English" literature. In addition, reports were also identified from citations by others or review articles. Studies were considered for inclusion in the CYP2C19 frequency table if: (1) the ethnicity of the population was clearly indicated, (2) either allele frequencies or genotype frequencies were reported, (3) the method by which the genes were genotyped was indicated, (4) the sample population consisted of at least 50 individuals with a few exceptions (e.g., smaller cohorts that were part of larger studies) and (5) the study represented an original publication (no reviews or meta-analyses). Diplotype and phenotype frequencies were estimated using the equation describing Hardy Weinberg equilibrium based on reported allele frequencies.\n\nDiplotype and Phenotype Calculations. Diplotype and phenotype frequencies were estimated using the equation describing Hardy Weinberg equilibrium based on reported allele frequencies.\n\nCaveats to estimated allele, diplotype and phenotype frequencies:\n\nSampling. Allele frequencies collected by CPIC for the supplemental tables are based on published literature reports which typically study small groups of people based on a geographic location (e.g. Malaysia, Berlin, Cairo). Almost no studies use genetic markers to estimate ancestry. Manuscripts are often focused on a specific phenotype (e.g. disease) or study only individuals taking a particular drug. Such samples would not be considered a random sample of the general population. Another consideration is that sample size is important, and PGx studies are typically not large. The frequencies collected from these studies are then used to estimate general estimates of entire ethnic population allele frequencies. Therefore, frequencies from larger groups of subjects and frequencies averaged from many sample populations probably result in better estimates.\n\nEstimation of *1 frequency. In general, there are no population studies that test for all known variant alleles. Because *1 is not genotyped directly in many studies, all alleles that are negative for a sequence variation are defaulted to a *1 assignment. The inferred frequency for *1 is estimated as: 100 - (sum of averaged variant allele frequencies). For genes where many alleles are not tested for in any population, and frequency of 'common' alleles is not well documented in many understudied populations (Oceanian, Central/South Asian, Latino), the *1 frequency will deviate even more from true values.\n\nDiplotype/Phenotype frequency estimates. Diplotype and phenotype frequencies were estimated using the equation describing Hardy Weinberg equilibrium based on reported allele frequencies. When calculating diplotype frequencies from these allele frequencies, the margin of error is compounded based on the margin of error on each allele in the diplotype. So, the margin of error will necessarily increase for diplotype frequency estimates compared to allele frequency estimates. For allele frequencies with already large margins of error due to small and non-random sampling, the diplotype margin of error could potentially be quite large. On the other hand, for well-studied alleles, the margin of error is likely low.\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details, including the definitions of each group, can be found at https://www.pharmgkb.org/page/biogeographicalGroups. We strongly recommend that users use either the publication or the PharmGKB link provided to familiarize themselves with the grouping system before using these allele frequencies. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.	PHENOTYPE	396	\N	https://cpicpgx.org/gene/cyp2c19/	\N	Legacy Name/Class	t	t
G6PD	chrX	NG_009015.2	NP_000101.2	NC_000023.11	NM_001042351.2	HGNC:4057	2539	ENSG00000160211	PA28469	Methods\n\nThe allele frequency table was made by searching the gnomAD database.\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details can be found at https://www.pharmgkb.org/page/biogeographicalGroups. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n	PHENOTYPE	341	\N	https://cpicpgx.org/gene/g6pd/	\N	Legacy Name/Class	f	f
TPMT	chr6	NG_012137.2	NP_000358.1	NC_000006.12	NM_000540.2	HGNC:12014	7172	ENSG00000137364	PA356	The allele frequency table was made by searching the PubMed® database (no start date to 1/2018). Allele frequencies reported in the gnomAD browser (http://gnomad.broadinstitute.org/ - exomes and genomes) and ensembl (grch37.ensembl.org - exomes or genomes) were also included. URLs are included in the "PMID" column.\n\nDiplotype and Phenotype Calculations. Diplotype and phenotype frequencies were estimated using the equation describing Hardy Weinberg equilibrium based on reported allele frequencies.\n\nCaveats to estimated allele, diplotype and phenotype frequencies:\n\nSampling. Allele frequencies collected by CPIC for the supplemental tables are based on published literature reports which typically study small groups of people based on a geographic location (e.g. Malaysia, Berlin, Cairo). Almost no studies use genetic markers to estimate ancestry. Manuscripts are often focused on a specific phenotype (e.g. disease) or study only individuals taking a particular drug. Such samples would not be considered a random sample of the general population. Another consideration is that sample size is important, and PGx studies are typically not large. The frequencies collected from these studies are then used to estimate general estimates of entire ethnic population allele frequencies. Therefore, frequencies from larger groups of subjects and frequencies averaged from many sample populations probably result in better estimates.\n\nEstimation of *1 frequency. In general, there are no population studies that test for all known variant alleles. Because *1 is not genotyped directly in many studies, all alleles that are negative for a sequence variation are defaulted to a *1 assignment. The inferred frequency for *1 is estimated as: 100 - (sum of averaged variant allele frequencies). For genes where many alleles are not tested for in any population, and frequency of 'common' alleles is not well documented in many understudied populations (Oceania, South Asian, Latino), the *1 frequency will deviate even more from true values.\n\nDiplotype/Phenotype frequency estimates. Diplotype and phenotype frequencies were estimated using the equation describing Hardy Weinberg equilibrium based on reported allele frequencies. When calculating diplotype frequencies from these allele frequencies, the margin of error is compounded based on the margin of error on each allele in the diplotype. So, the margin of error will necessarily increase for diplotype frequency estimates compared to allele frequency estimates. For allele frequencies with already large margins of error due to small and non-random sampling, the diplotype margin of error could potentially be quite large. On the other hand, for well-studied alleles, the margin of error is likely low.\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details can be found at https://www.pharmgkb.org/page/biogeographicalGroups. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.	PHENOTYPE	385	\N	https://cpicpgx.org/gene/tpmt/	\N	Nucleotide change on cDNA from https://liu.se/en/research/tpmt-nomenclature-committee	t	t
IFNL3	chr19	NG_042193.1	NP_000101.2	NC_000019.10	NM_001042351.2	HGNC:18365	282617	ENSG00000197110	PA134952671	\N	ALLELE_STATUS	208	\N	https://cpicpgx.org/gene/ifnl/	\N	Common Name	t	t
CYP2B6	chr19	NG_007929.1	NP_000758.1	NC_000019.10	NM_000069.2	HGNC:2615	1555	ENSG00000197408	PA123	Methods\n\nThe allele frequency table was made by searching the PubMed® database (no start date to May 2018). Studies were considered for inclusion in the CYP2B6 Frequency Table if (1) the ethnicity of the population was clearly indicated; (2) either allele frequencies or genotype frequencies were reported; and (3) the method by which genes were genotyped was indicated. Allele frequencies reported in the gnomAD browser (http://gnomad.broadinstitute.org/ - exomes and genomes) and 1000 Genomes Project phase 3 data on Ensemble browser (https://uswest.ensembl.org/index.html) were also included.\n\nDiplotype and Phenotype Calculations. Diplotype and phenotype frequencies were estimated using the equation describing Hardy Weinberg equilibrium based on reported allele frequencies.\n\nCaveats to estimated allele, diplotype and phenotype frequencies:\n\nSampling. Allele frequencies collected by CPIC for the supplemental tables are based on published literature reports which typically study small groups of people based on a geographic location (e.g. Malaysia, Berlin, Cairo). Almost no studies use genetic markers to estimate ancestry. Manuscripts are often focused on a specific phenotype (e.g. disease) or study only individuals taking a particular drug. Such samples would not be considered a random sample of the general population. Another consideration is that sample size is important, and PGx studies are typically not large. Studies were included in the frequency calculation regardless of number. The frequencies collected from these studies are then used to estimate general estimates of entire ethnic population allele frequencies. Therefore, frequencies from larger groups of subjects and frequencies averaged from many sample populations probably result in better estimates.\n\nEstimation of *1 frequency. In general, there are no population studies that test for all known variant alleles. Because *1 is not genotyped directly in many studies, all alleles that are negative for a sequence variation are defaulted to a *1 assignment. The inferred frequency for *1 is estimated as: 1 - (sum of averaged variant allele frequencies). For genes where many alleles are not tested for in any population, and frequency of 'common' alleles is not well documented in many understudied populations (Oceania, Middle eastern, South Asian, Latino), the *1 frequency will deviate even more from true values.\n\nDiplotype/Phenotype frequency estimates. Diplotype and phenotype frequencies were estimated using the equation describing Hardy Weinberg equilibrium based on reported allele frequencies. When calculating diplotype frequencies from these allele frequencies, the margin of error is compounded based on the margin of error on each allele in the diplotype. So, the margin of error will necessarily increase for diplotype frequency estimates compared to allele frequency estimates. For allele frequencies with already large margins of error due to small and non-random sampling, the diplotype margin of error could potentially be quite large. On the other hand, for well-studied alleles, the margin of error is likely low.\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details, including the definitions of each group, can be found at https://www.pharmgkb.org/page/biogeographicalGroups. We strongly recommend that users use either the publication or the PharmGKB link provided to familiarize themselves with the grouping system before using these allele frequencies. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.	PHENOTYPE	397	\N	https://cpicpgx.org/gene/cyp2b6/	\N	Legacy Name/Class	t	t
VKORC1	chr16	NG_011564.1	NP_076869.1	NC_000016.10	NM_000540.2	HGNC:23663	79001	ENSG00000167397	PA133787052	Methods\n\nThe allele frequency table was made by searching the PubMed® database (1995 to 2016). Allele frequencies reported in phase 3 1000 Genomes were also included (http://browser.1000genomes.org/index.html).\n\nCaveats to estimated allele, diplotype and phenotype frequencies:\n\nSampling. Allele frequencies collected by CPIC for the supplemental tables are based on published literature reports which typically study small groups of people based on a geographic location (e.g. Malaysia, Berlin, Cairo). Almost no studies use genetic markers to estimate ancestry. Manuscripts are often focused on a specific phenotype (e.g. disease) or study only individuals taking a particular drug. Such samples would not be considered a random sample of the general population. Another consideration is that sample size is important, and PGx studies are typically not large. The frequencies collected from these studies are then used to estimate general estimates of entire ethnic population allele frequencies. Therefore, frequencies from larger groups of subjects and frequencies averaged from many sample populations probably result in better estimates.\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details can be found at https://www.pharmgkb.org/page/biogeographicalGroups. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.	PHENOTYPE	304	VKORC1 diplotype to phenotype translation is not applicable to the warfarin guideline.	https://cpicpgx.org/gene/vkorc1/	\N	Common Name	f	f
CACNA1S	chr1	NG_009816.1	NP_000060.2	NC_000001.11	NM_000069.2	HGNC:1397	779	ENSG00000081248	PA85	Methods\n\nThe allele frequency table was made by searching the Genome Aggregation Database (gnomAD) by each rsID\n\nCaveats to estimated allele, frequencies:\n\nSampling. Allele frequencies collected by CPIC for the supplemental tables are based on published literature reports which typically study small groups of people based on a geographic location (e.g. Malaysia, Berlin, Cairo). Almost no studies use genetic markers to estimate ancestry. Manuscripts are often focused on a specific phenotype (e.g. disease) or study only individuals taking a particular drug. Such samples would not be considered a random sample of the general population. Another consideration is that sample size is important, and PGx studies are typically not large. The frequencies collected from these studies are then used to estimate general estimates of entire ethnic population allele frequencies. Therefore, frequencies from larger groups of subjects and frequencies averaged from many sample populations probably result in better estimates.\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details, including the definitions of each group, can be found at https://www.pharmgkb.org/page/biogeographicalGroups. We strongly recommend that users use either the publication or the PharmGKB link provided to familiarize themselves with the grouping system before using these allele frequencies. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.	PHENOTYPE	398	\N	https://cpicpgx.org/gene/cacna1s/	\N	\N	f	f
\.


--
-- Data for Name: gene_result; Type: TABLE DATA; Schema: cpic; Owner: -
--

COPY cpic.gene_result (id, genesymbol, result, activityscore, ehrpriority, consultationtext, version, frequency) FROM stdin;
6511065	CYP3A5	Poor Metabolizer	n/a	Normal/Routine/Low Risk	This result signifies that the patient has two copies of a no function allele. Patients with this genotype are expected to require standard tacrolimus dosing. Please consult a clinical pharmacist for more specific dosing information.	3	{"Latino": 0.68427247, "European": 0.85728335, "East Asian": 0.5571847, "Near Eastern": 0.770986, "Central/South Asian": 0.45330563, "Sub-Saharan African": 0.2710154, "African American/Afro-Caribbean": 0.2993679}
6511060	CYP3A5	Intermediate Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a normal function allele and one copy of a no function allele. Patients with this genotype are expected to require higher starting tacrolimus dosing (1.5 times to 2 times the standard dose-maximum starting dose not to exceed 0.3mg/kg/day). Further dose adjustments or selection of alternative therapy may be necessary due to other clinical factors (e.g., medication interactions, or hepatic function). Please consult a clinical pharmacist for more specific dosing information.	3	{"Latino": 0.28587034, "European": 0.13722531, "East Asian": 0.37852672, "Near Eastern": 0.21414419, "Central/South Asian": 0.43994826, "Sub-Saharan African": 0.499152, "African American/Afro-Caribbean": 0.4955547}
6511077	CYP3A5	Indeterminate	n/a	none	This result signifies that the patient has an allele combination with uncertain and/or unknown function alleles. The expected phenotype for this patient cannot be determined currently based on the CYP3A5 diplotype result. Please consult a clinical pharmacist for more specific information about how CYP3A5 function influences drug dosing.	3	{"Latino": 0.0, "European": 0.0, "East Asian": 0.0, "Near Eastern": 0.0, "Central/South Asian": 0.0, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": 0.0}
6489590	CYP2B6	Poor Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has two copies of a no function allele OR two copies of a decreased function allele OR one copy of a no function allele and one copy of a decreased function allele. Based on the genotype result this patient is predicted to be a poor metabolizer of CYP2B6 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2B6. To avoid an untoward drug response, dose adjustments or or alternative therapy may be necessary for medications metabolized by CYP2B6. Please consult a clinical pharmacist for more information about how CYP2B6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.09452413, "European": 0.07428478, "Oceanian": 0.4096, "East Asian": 0.0436291, "Near Eastern": 0.127449, "Central/South Asian": 0.059536003, "Sub-Saharan African": 0.23673655, "African American/Afro-Caribbean": 0.15714757}
6494159	CYP2D6	Ultrarapid Metabolizer	≥5.0	Abnormal/Priority/High Risk	This result signifies that this patient has [X copies of a normal function allele (*_xN)] [X copies of a decreased function allele (*_)] [X copies of a no function allele (*_)]. Based on the genotype result this patient is predicted to be an ultrarapid metabolizer of CYP2D6 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2D6. To avoid an untoward drug response, dose adjustments may be necessary for medications metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.000055729302, "American": 0.00006450697, "European": 0.000058472542, "Oceanian": 0.0, "East Asian": 0.000015887783, "Near Eastern": 0.0, "Central/South Asian": 0.0, "Sub-Saharan African": 0.00025361063, "African American/Afro-Caribbean": 0.0}
6494239	CYP2D6	Ultrarapid Metabolizer	≥3.25	Abnormal/Priority/High Risk	This result signifies that this patient has [X copies of a normal function allele (*_xN)] [X copies of a decreased function allele (*_)] [X copies of a no function allele (*_)]. Based on the genotype result this patient is predicted to be an ultrarapid metabolizer of CYP2D6 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2D6. To avoid an untoward drug response, dose adjustments may be necessary for medications metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.00018561553, "American": 0.00009731066, "European": 0.00046782166, "Oceanian": 0.0, "East Asian": 0.0009120896, "Near Eastern": 0.0, "Central/South Asian": 0.0, "Sub-Saharan African": 0.000952962, "African American/Afro-Caribbean": 0.0}
6494928	CYP2D6	Normal Metabolizer	1.5	Normal/Routine/ Low Risk	This result signifies that this patient has [1 copy of a normal function allele (*_)] [X copies of a decreased function allele (*_)] [X copies of a no function allele (*_)]. Based on the genotype result this patient is predicted to be a normal metabolizer of CYP2D6 substrates. There is no reason to selectively adjust the dose of most medications that are metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.051568672, "American": 0.012521543, "European": 0.010339902, "Oceanian": 0.00143701, "East Asian": 0.017062929, "Near Eastern": 0.045171212, "Central/South Asian": 0.0029989334, "Sub-Saharan African": 0.23161727, "African American/Afro-Caribbean": 0.23827769}
6494263	CYP2D6	Ultrarapid Metabolizer	≥3.0	Abnormal/Priority/High Risk	This result signifies that this patient has [X copies of a normal function allele (*_xN)] [X copies of a decreased function allele (*_)] [X copies of a no function allele (*_)]. Based on the genotype result this patient is predicted to be an ultrarapid metabolizer of CYP2D6 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2D6. To avoid an untoward drug response, dose adjustments may be necessary for medications metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.00035315607, "American": 0.0002839765, "European": 0.0008605249, "Oceanian": 0.0, "East Asian": 0.00018026348, "Near Eastern": 0.0, "Central/South Asian": 0.0, "Sub-Saharan African": 0.001428226, "African American/Afro-Caribbean": 0.0}
6511089	DPYD	Normal Metabolizer	2.0	Normal/Routine/Low Risk	This result signifies that the patient has two copies of normal function DPYD alleles. Based on the genotype result this patient is predicted to be DPYD Normal Metabolizer with a DPYD activity score of 2. For this genotype, no selective dose adjustment is indicated for medications that are metabolized by DPD. Please consult a clinical pharmacist for more information about how DPD metabolic status influences drug selection and dosing.	2	\N
6512687	DPYD	Intermediate Metabolizer	1.5	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a normal function allele and one copy of a decreased function allele of the DPYD gene. Based on the genotype result this patient is predicted to be a DPYD Intermediate Metabolizer with a DPYD activity score of 1.5. This patient may be at risk for adverse drug reactions to medications that are metabolized by DPD (i.e. 5-fluorouracil, capecitabine, and tegafur) and a dose adjustment may be indicated. Please consult a clinical pharmacist for more information about how DPD metabolic status influences drug selection and dosing.	2	\N
6513081	DPYD	Intermediate Metabolizer	1.0	Abnormal/Priority/High Risk	This result signifies that the patient has either one copy of a normal function allele and one copy of a no function allele of the DPYD gene OR two copies of decreased function alleles of the DPYD gene. Based on the genotype result this patient is predicted to be a DPYD Intermediate Metabolizer with a DPYD activity score of 1. This patient may be at risk for adverse drug reactions to medications that are metabolized by DPD (i.e. 5-fluorouracil, capecitabine, and tegafur) and a dose adjustment may be indicated. Please consult a clinical pharmacist for more information about how DPD metabolic status influences drug selection and dosing.	2	\N
6514288	DPYD	Poor Metabolizer	0.5	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a decreased function allele and one copy of a no function allele of the DPYD gene. Based on the genotype result this patient is predicted to be a DPYD Poor Metabolizer with a DPYD activity score of 0.5. This patient may be at risk for adverse drug reactions to medications that are metabolized by DPD (i.e. 5-fluorouracil, capecitabine, and tegafur) and a dose adjustment or alternative therapeutic agents may be indicated. Please consult a clinical pharmacist for more information about how DPD metabolic status influences drug selection and dosing.	2	\N
6514437	DPYD	Poor Metabolizer	0.0	Abnormal/Priority/High Risk	This result signifies that the patient has two copies of no function alleles of the DPYD gene. Based on the genotype result this patient is predicted to be a DPYD Poor Metabolizer with a DPYD activity score of 0. This patient may be at risk for adverse drug reactions to medications that are metabolized by DPD (i.e. 5-fluorouracil, capecitabine, and tegafur) and alternative therapeutic agents may be indicated. Please consult a clinical pharmacist for more information about how DPD metabolic status influences drug selection and dosing.	2	\N
6490636	CYP2C19	Likely Intermediate Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a normal function allele and one copy of a decreased function allele OR one copy of an increased function allele and one copy of a decreased function allele OR two copies of a decreased function allele. Based on the genotype result this patient MAY be an intermediate metabolizer of CYP2C19 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2C19. To avoid an untoward drug response, dose adjustments or alternative therapeutic agents may be necessary for medications metabolized by CYP2C19. Please consult a clinical pharmacist for more information about how CYP2C19 metabolic status influences drug selection and dosing.	3	{"Latino": 0.003709162, "American": 0.0, "European": 0.0011160374, "Oceanian": 0.0, "East Asian": 0.00076989824, "Near Eastern": 0.0, "Central/South Asian": 0.0, "Sub-Saharan African": 0.042863965, "African American/Afro-Caribbean": 0.027788177}
6490597	CYP2C19	Rapid Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a normal function allele and one copy of an increased function allele. Based on the genotype result this patient is predicted to be a rapid metabolizer of CYP2C19 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2C19. To avoid an untoward drug response, dose adjustments or alternative therapeutic agents may be necessary for medications metabolized by CYP2C19. Please consult a clinical pharmacist for more information about how CYP2C19 metabolic status influences drug selection and dosing.	3	{"Latino": 0.24136075, "American": 0.13638271, "European": 0.2711846, "Oceanian": 0.021329276, "East Asian": 0.025343522, "Near Eastern": 0.2573682, "Central/South Asian": 0.18567303, "Sub-Saharan African": 0.21080859, "African American/Afro-Caribbean": 0.2373838}
6494361	CYP2D6	Ultrarapid Metabolizer	4.0	Abnormal/Priority/High Risk	This result signifies that this patient has [X copies of a normal function allele (*_xN)] [X copies of a decreased function allele (*_)] [X copies of a no function allele (*_)]. Based on the genotype result this patient is predicted to be an ultrarapid metabolizer of CYP2D6 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2D6. To avoid an untoward drug response, dose adjustments may be necessary for medications metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.0007764387, "American": 0.0010402872, "European": 0.0003002313, "Oceanian": 0.014133941, "East Asian": 0.000063105406, "Near Eastern": 0.0041771694, "Central/South Asian": 0.00016144973, "Sub-Saharan African": 0.0006431835, "African American/Afro-Caribbean": 0.0007742127}
6494570	CYP2D6	Normal Metabolizer	2.25	Normal/Routine/ Low Risk	This result signifies that this patient has two copies of a normal function allele (*_x2) and one copy of decreased function allele with an activity value of 0.25 (*_). Based on the genotype result this patient is predicted to be a normal metabolizer of CYP2D6 substrates. There is no reason to selectively adjust the dose of most medications that are metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.005172111, "American": 0.0031386076, "European": 0.004804125, "Oceanian": 0.021296859, "East Asian": 0.0072455397, "Near Eastern": 0.029094387, "Central/South Asian": 0.005050826, "Sub-Saharan African": 0.0048336256, "African American/Afro-Caribbean": 0.004428509}
6514677	G6PD	Deficient	n/a	Abnormal/Priority/High Risk	Based on the genotype result, this patient is predicted to be G6PD deficient and is at risk for developing hemolytic anemia when exposed to certain medications (such as dapsone, methylene blue, pegloticase, primaquine (at certain doses), rasburicase, tafenoquine, toluidine blue) or foods (such as fava beans). Please consult a clinical pharmacist for more information.	2	\N
6514770	G6PD	Deficient with CNSHA	n/a	Abnormal/Priority/High Risk	Based on the genotype result, this patient is predicted to be G6PD deficient with CNSHA and is at risk for developing or worsening hemolytic anemia when exposed to certain medications (such as dapsone, methylene blue, pegloticase, primaquine (at certain doses), rasburicase, tafenoquine, toluidine blue) or foods (such as fava beans). Please consult a clinical pharmacist for more information.	2	\N
6531340	G6PD	Indeterminate	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has an allele combination with uncertain and/or unknown function alleles. The expected phenotype for this patient cannot be determined currently based on genotype alone. A G6PD enzyme activity test is recommended to assess for G6PD deficiency. Please consult a clinical pharmacist for more specific information about how G6PD function influences drug dosing.	2	\N
6514670	G6PD	Normal	n/a	Normal Risk	Based on the genotype result, this patient is predicted to have normal G6PD enzyme activity. This means there is no reason to selectively avoid G6PD associated medications based on the G6PD status alone. Please consult a clinical pharmacist for more information.	2	\N
6514874	G6PD	Variable	n/a	Abnormal/Priority/High Risk	This patient carries one copy of a deficient G6PD allele and one copy of a normal G6PD allele. Due to X inactivation, patients who are heterozygous with one deficient allele and one normal allele may exhibit G6PD activity ranging from normal to deficient. A G6PD enzyme activity test is recommended to assess for G6PD deficiency. Please consult a clinical pharmacist for more information.	2	\N
6494949	CYP2D6	Normal Metabolizer	1.25	Normal/Routine/ Low Risk	This result signifies that this patient has [1 copy of a normal function allele (*_)] or [2 copies of a decreased function allele with an activity value of 0.5 (*_x2)] and [1 copy of a decreased function allele with an activity value of 0.25 (*_)] OR *41x3 and [1 copy of a decreased function allele with an activity value of 0.5 (*_)] or [2 copies of a decreased function allele with an activity value of 0.25 (*_x2)]. Based on the genotype result this patient is predicted to be a normal metabolizer of CYP2D6 substrates. There is no reason to selectively adjust the dose of most medications that are metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.11888533, "American": 0.07351474, "European": 0.15507403, "Oceanian": 0.12359433, "East Asian": 0.3547828, "Near Eastern": 0.22410923, "Central/South Asian": 0.23109229, "Sub-Saharan African": 0.073030114, "African American/Afro-Caribbean": 0.07348749}
6494977	CYP2D6	Intermediate Metabolizer	0.75	Abnormal/Priority/High Risk	This result signifies that this patient has has three copies of *41 (*41x3) and one copy of a no function allele (*_) OR [1 copy of a decreased function allele with an activity value of 0.25 (*_)] and [1 copy of a decreased function allele with an activity value of 0.5 (*_)] or [2 copies of a decreased function allele with an activity value of 0.25 (*_x2)] . Based on the genotype result this patient is predicted to be an intermediate metabolizer of CYP2D6 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2D6. To avoid an untoward drug response, dose adjustments may be necessary for medications metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.0074723335, "American": 0.00080644403, "European": 0.0025628314, "Oceanian": 0.00018655165, "East Asian": 0.020004882, "Near Eastern": 0.02042247, "Central/South Asian": 0.0010252715, "Sub-Saharan African": 0.05760366, "African American/Afro-Caribbean": 0.041067164}
6494154	CYP2D6	Ultrarapid Metabolizer	≥6.0	Abnormal/Priority/High Risk	This result signifies that this patient has [X copies of a normal function allele (*_xN)] [X copies of a decreased function allele (*_)] [X copies of a no function allele (*_)]. Based on the genotype result this patient is predicted to be an ultrarapid metabolizer of CYP2D6 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2D6. To avoid an untoward drug response, dose adjustments may be necessary for medications metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.0000010000001, "American": 0.0000010000001, "European": 0.0000028470035, "Oceanian": 0.0, "East Asian": 0.0000010000001, "Near Eastern": 0.0, "Central/South Asian": 0.0, "Sub-Saharan African": 0.000025000001, "African American/Afro-Caribbean": 0.0}
6494177	CYP2D6	Ultrarapid Metabolizer	≥4.0	Abnormal/Priority/High Risk	This result signifies that this patient has [X copies of a normal function allele (*_xN)] [X copies of a decreased function allele (*_)] [X copies of a no function allele (*_)]. Based on the genotype result this patient is predicted to be an ultrarapid metabolizer of CYP2D6 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2D6. To avoid an untoward drug response, dose adjustments may be necessary for medications metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.0012809848, "American": 0.0015109289, "European": 0.0018874556, "Oceanian": 0.0, "East Asian": 0.0007779561, "Near Eastern": 0.0, "Central/South Asian": 0.0, "Sub-Saharan African": 0.0038317435, "African American/Afro-Caribbean": 0.0}
6483918	ABCG2	Normal Function	n/a	Normal/Routine/Low Risk	This result signifies that the patient has two copies of a normal function allele. Based on the genotype result, this patient is predicted to have normal ABCG2 function. This means that there is no reason to adjust the dose of most medications that are affected by ABCG2 on the basis of ABCG2 genetic status. Please consult a clinical pharmacist for more specific information about how ABCG2 function influences drug dosing.	3	{"Latino": 0.6015554, "American": 0.64000005, "European": 0.8035329, "Oceanian": 0.63246274, "East Asian": 0.4801104, "Near Eastern": 0.87366414, "Central/South Asian": 0.8222862, "Sub-Saharan African": 0.9883421, "African American/Afro-Caribbean": 0.9314832}
6494173	CYP2D6	Ultrarapid Metabolizer	≥3.75	Abnormal/Priority/High Risk	This result signifies that this patient has [X copies of a normal function allele (*_xN)] [X copies of a decreased function allele (*_)] [X copies of a no function allele (*_)]. Based on the genotype result this patient is predicted to be an ultrarapid metabolizer of CYP2D6 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2D6. To avoid an untoward drug response, dose adjustments may be necessary for medications metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.0, "American": 0.0, "European": 0.0, "Oceanian": 0.0, "East Asian": 0.0, "Near Eastern": 0.0, "Central/South Asian": 0.0, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": 0.0}
6494211	CYP2D6	Ultrarapid Metabolizer	≥3.5	Abnormal/Priority/High Risk	This result signifies that this patient has [X copies of a normal function allele (*_xN)] [X copies of a decreased function allele (*_)] [X copies of a no function allele (*_)]. Based on the genotype result this patient is predicted to be an ultrarapid metabolizer of CYP2D6 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2D6. To avoid an untoward drug response, dose adjustments may be necessary for medications metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.00008051411, "American": 0.00001657463, "European": 0.000031193038, "Oceanian": 0.0, "East Asian": 0.00004386605, "Near Eastern": 0.0, "Central/South Asian": 0.0, "Sub-Saharan African": 0.0030223487, "African American/Afro-Caribbean": 0.0}
6498956	CYP2D6	Indeterminate	n/a	none	This result signifies that the patient has an allele combination with uncertain and/or unknown function alleles. The expected phenotype for this patient cannot be determined currently based on the CYP2D6 diplotype result. Please consult a clinical pharmacist for more specific information about how CYP2D6 function influences drug dosing.	3	{"Latino": 0.041558996, "American": 0.02454997, "European": 0.03725156, "Oceanian": 0.087338224, "East Asian": 0.066782884, "Near Eastern": 0.03744279, "Central/South Asian": 0.09993659, "Sub-Saharan African": 0.09009597, "African American/Afro-Caribbean": 0.038868744}
6511057	CYP3A5	Normal Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has two copies of a normal function allele. Patients with this genotype are expected to require higher starting tacrolimus dosing (1.5 times to 2 times the standard dose-maximum starting dose not to exceed 0.3mg/kg/day). Further dose adjustments or selection of alternative therapy may be necessary due to other clinical factors (e.g., medication interactions, or hepatic function). Please consult a clinical pharmacist for more specific dosing information.	3	{"Latino": 0.029857205, "European": 0.005491413, "East Asian": 0.064288594, "Near Eastern": 0.014869832, "Central/South Asian": 0.106746115, "Sub-Saharan African": 0.22983262, "African American/Afro-Caribbean": 0.20507748}
6532465	MT-RNR1	normal risk of aminoglycoside-induced hearing loss	n/a	Normal/Routine/Low Risk	This result signifies that MT-RNR1 variants associated with aminoglycoside-induced hearing loss were not detected in this patient. Based on this genotype result, no change in aminoglycoside therapy is warranted. It should be noted that this result does not absolutely rule out the possibility of the patient developing ototoxicity with aminoglycoside use.	2	\N
6483921	CACNA1S	Malignant Hyperthermia Susceptibility	n/a	Abnormal/Priority/High Risk	This result signifies that this patient has one copy of a variant [variant] associated with malignant hyperthermia susceptibility. Halogenated volatile anesthetics or depolarizing muscle relaxants are relatively contraindicated in persons with MHS. They should not be used, except in extraordinary circumstances where the benefits outweigh the risks. Please consult a MHS specialist or contact MHAUS (https://www.mhaus.org/healthcare-professionals/) for further information.	2	\N
6483929	CACNA1S	Uncertain Susceptibility	n/a	Normal Risk	Variation in RYR1 and/or CACNA1S genes is associated with increased risk of Malignant hyperthermia after administration of depolarizing muscle relaxants and potent volatile anesthetics. Although listed causative CACNA1S variants were NOT detected in this patient, it should be noted that this finding does not absolutely rule out the possibility of malignant hyperthermia. These results should be interpreted in the context of other genetic and clinical findings, family history and other laboratory data.	2	\N
6532490	NAT2	Rapid Metabolizer	n/a	Priority/High Risk	This result signifies that the patient has inherited two increased function alleles. Based on the genotype result this patient is predicted to be a rapid metabolizer of NAT2 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by NAT2. To avoid an untoward drug response, dose adjustments or alternative therapeutic agents may be necessary for medications metabolized by NAT2. Please consult a clinical pharmacist for more information about how NAT2 metabolic status influences drug selection and dosing.	2	\N
6532495	NAT2	Intermediate Metabolizer	n/a	Priority/High Risk	This result signifies that the patient has inherited one increased function allele and one decreased function allele. Based on the genotype result this patient is predicted to be an intermediate metabolizer of NAT2 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by NAT2. To avoid an untoward drug response, dose adjustments or alternative therapeutic agents may be necessary for medications metabolized by NAT2. Please consult a clinical pharmacist for more information about how NAT2 metabolic status influences drug selection and dosing.	2	\N
6532569	NAT2	Poor Metabolizer	n/a	Priority/High Risk	This result signifies that the patient has inherited two decreased function alleles. Based on the genotype result this patient is predicted to be a poor metabolizer of NAT2 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by NAT2. To avoid an untoward drug response, dose adjustments or alternative therapeutic agents may be necessary for medications metabolized by NAT2. Please consult a clinical pharmacist for more information about how NAT2 metabolic status influences drug selection and dosing.	2	\N
6533237	NAT2	Indeterminate	n/a	none	This result signifies that the patient has inhertied an allele combination with uncertain and/or unknown function alleles. The expected phenotype for this patient cannot be determined currently based on the NAT2 diplotype result. Please consult a clinical pharmacist for more specific information about how NAT2 function influences drug dosing.	2	\N
6511073	CYP3A5	Possible Intermediate Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a normal function allele and one copy of an uncertain or unknown function allele. Patients with this genotype are expected to require higher starting tacrolimus dosing (1.5 times to 2 times the standard dose-maximum starting dose not to exceed 0.3mg/kg/day). Further dose adjustments or selection of alternative therapy may be necessary due to other clinical factors (e.g., medication interactions, or hepatic function). Please consult a clinical pharmacist for more specific dosing information.	3	{"Latino": 0.0, "European": 0.0, "East Asian": 0.0, "Near Eastern": 0.0, "Central/South Asian": 0.0, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": 0.0}
6533935	NUDT15	Normal Metabolizer	n/a	Normal/Routine/Low Risk	This result signifies that the patient has two copies of a normal function allele. Based on the genotype result this patient is predicted to be a NUDT15 normal metabolizer. There is no reason to selectively adjust the dose of most medications that are metabolized by NUDT15. Please consult a clinical pharmacist for more information about how NUDT15 metabolic status influences drug selection and dosing.	3	{"Latino": 0.8768086, "European": 0.98630786, "East Asian": 0.77218705, "Central/South Asian": 0.86494493}
6533938	NUDT15	Intermediate Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a normal function allele and one copy of a no function allele. Based on the genotype result this patient is predicted to be a NUDT15 intermediate metabolizer. This patient may be at risk for an adverse reactions to medications that are metabolized by NUDT15 (eg thiopurines). To avoid an untoward drug response, dose adjustments or alternative therapeutic agents may be necessary for medications metabolized by NUDT15. Please consult a clinical pharmacist for more information about how NUDT15 metabolic status influences drug selection and dosing.	3	{"Latino": 0.082887314, "European": 0.0076054693, "East Asian": 0.16783968, "Central/South Asian": 0.12554385}
6533943	NUDT15	Poor Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has two copies of a no function allele. Based on the genotype result this patient is predicted to be a NUDT15 poor metabolizer. This patient may be at a high risk for an adverse reactions to medications that are metabolized by NUDT15 (eg. thiopurines). To avoid an untoward drug response, dose adjustments or or alternative therapy may be necessary for medications metabolized by NUDT15. Please consult a clinical pharmacist for more information about how NUDT15 metabolic status influences drug selection and dosing.	3	{"Latino": 0.0019588957, "European": 0.000014661539, "East Asian": 0.00912025, "Central/South Asian": 0.0045555667}
6533951	NUDT15	Indeterminate	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has an allele combination with uncertain and/or unknown function alleles. The expected phenotype for this patient cannot be determined currently based on the NUDT15 diplotype result. If thiopurines are required and NUDT15 status is unknown, monitor closely for toxicity. Please consult a clinical pharmacist for more specific information about how NUDT15 function influences drug dosing.	3	{"Latino": 0.03663146, "European": 0.006048766, "East Asian": 0.045933217, "Central/South Asian": 0.0046207304}
6533958	NUDT15	Possible Intermediate Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of an uncertain function allele and one copy of a no function allele. Based on the genotype result this patient is predicted to be a NUDT15 possible intermediate metabolizer. This patient may be at risk for an adverse reactions to medications that are metabolized by NUDT15 (eg thiopurines). To avoid an untoward drug response, dose adjustments or alternative therapeutic agents may be necessary for medications metabolized by NUDT15. Please consult a clinical pharmacist for more information about how NUDT15 metabolic status influences drug selection and dosing.	3	{"Latino": 0.0017137243, "European": 0.000023285522, "East Asian": 0.0049198293, "Central/South Asian": 0.00033489507}
6483932	CFTR	ivacaftor responsive in CF patients	n/a	\N	\N	1	\N
6489394	CFTR	ivacaftor non-responsive in CF patients	n/a	\N	\N	1	\N
6565621	RYR1	Malignant Hyperthermia Susceptibility	n/a	Abnormal/Priority/High Risk	This result signifies that this patient has one copy of a variant [variant] associated with malignant hyperthermia susceptibility. Halogenated volatile anesthetics or depolarizing muscle relaxants are relatively contraindicated in persons with MHS. They should not be used, except in extraordinary circumstances where the benefits outweigh the risks. Please consult a MHS specialist or contact MHAUS (https://www.mhaus.org/healthcare-professionals/) for further information.	2	\N
6533991	RYR1	Uncertain Susceptibility	n/a	Normal Risk	Variation in RYR1 and/or CACNA1S genes is associated with increased risk of Malignant hyperthermia after administration of depolarizing muscle relaxants and potent volatile anesthetics. Although listed causative RYR1 variants were NOT detected in this patient, it should be noted that this finding does not absolutely rule out the possibility of malignant hyperthermia. These results should be interpreted in the context of other genetic and clinical findings, family history and other laboratory data.	2	\N
6592135	SLCO1B1	Possible Decreased Function	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a uncertain or unknown function allele (*_) and one copy of a no function allele (*_). Based on the genotype result, this patient is predicted to have possible decreased SLCO1B1 function. This patient may be at risk for an adverse response to medications that are affected by SLCO1B1. To avoid an untoward drug response, dose adjustments may be necessary for medications affected by SLCO1B1 (i.e. statins). Please consult a clinical pharmacist for more specific information about how SLCO1B1 function influences drug dosing.	3	{"American": 0.0, "European": 0.00029760195, "Oceanian": 0.0, "East Asian": 0.0011306308, "Near Eastern": 0.0, "Central/South Asian": 0.0000418451, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": 0.0}
6591974	SLCO1B1	Decreased Function	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a normal function allele (*_) and one copy of a no function allele (*_). Based on the genotype result, this patient is predicted to have decreased SLCO1B1 function. This patient may be at risk for an adverse response to medications that are affected by SLCO1B1. To avoid an untoward drug response, dose adjustments may be necessary for medications affected by SLCO1B1 (i.e. statins). Please consult a clinical pharmacist for more specific information about how SLCO1B1 function influences drug dosing.	3	{"American": 0.3648, "European": 0.28279552, "Oceanian": 0.0, "East Asian": 0.21842287, "Near Eastern": 0.32000002, "Central/South Asian": 0.12971397, "Sub-Saharan African": 0.054308295, "African American/Afro-Caribbean": 0.0198}
6591969	SLCO1B1	Increased Function	n/a	Normal/Routine/Low Risk	This result signifies that the patient has two copies of an increased function allele. Based on the genotype result, this patient is predicted to have increased SLCO1B1 function. This means that there is no reason to adjust the dose of most medications that are affected by SLCO1B1 on the basis of SLCO1B1 genetic status at this time. Please consult a clinical pharmacist for more specific information about how SLCO1B1 function influences drug dosing.	3	{"American": 0.0, "European": 0.029916462, "Oceanian": 0.0, "East Asian": 0.0, "Near Eastern": 0.0, "Central/South Asian": 0.0, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": 0.0}
6592000	SLCO1B1	Indeterminate	n/a	none	This result signifies that the patient has an allele combination with unknown or uncertain function alleles. The expected phenotype for this patient cannot be determined currently based on the SLCO1B1 diplotype result. Please consult a clinical pharmacist for more specific information about how SLCO1B1 function influences drug dosing.	3	{"American": 0.0, "European": 0.0014452906, "Oceanian": 0.0, "East Asian": 0.007855513, "Near Eastern": 0.0, "Central/South Asian": 0.0005580649, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": 0.0}
6591994	SLCO1B1	Normal Function	n/a	Normal/Routine/Low Risk	This result signifies that the patient has two copies of a normal function allele. Based on the genotype result, this patient is predicted to have normal SLCO1B1 function. This means that there is no reason to adjust the dose of most medications that are affected by SLCO1B1 on the basis of SLCO1B1 genetic status. Please consult a clinical pharmacist for more specific information about how SLCO1B1 function influences drug dosing.	3	{"American": 0.5776, "European": 0.6564144, "Oceanian": 1.0, "East Asian": 0.75683165, "Near Eastern": 0.64000005, "Central/South Asian": 0.8648222, "Sub-Saharan African": 0.94491136, "African American/Afro-Caribbean": 0.98010004}
6592065	SLCO1B1	Poor Function	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has two copies of a no function allele. Based on the genotype result, this patient is predicted to have low SLCO1B1 function. This patient may be at a high risk for an adverse response to medications that are affected by SLCO1B1 (i.e. statins). To avoid an untoward drug response, dose adjustments or alternative therapeutic agents may be necessary for medications affected by SLCO1B1. Please consult a clinical pharmacist for more specific information about how SLCO1B1 function influences drug dosing.	3	{"American": 0.0576, "European": 0.029130744, "Oceanian": 0.0, "East Asian": 0.015759302, "Near Eastern": 0.040000003, "Central/South Asian": 0.004863923, "Sub-Saharan African": 0.0007803353, "African American/Afro-Caribbean": 0.00010}
6593093	TPMT	Possible Intermediate Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of an uncertain/unknown function allele and one copy of a no function allele. Based on the genotype result this patient has a priority result (TPMT possible intermediate metabolizer) because their activity is not likely to be any higher than that of an intermediate metabolizer; if the uncertain/unknown function allele is also low, activity may be even lower than that of an intermediate metabolizer. This patient may be at risk for an adverse reactions to medications that are metabolized by TPMT (eg. thiopurines). To avoid an untoward drug response, dose adjustments or alternative therapeutic agents may be necessary for medications metabolized by TPMT. However, thiopurines can be affected by a patient's TPMT and NUDT15 phenotype. Please consult a clinical pharmacist for more information about how TPMT and NUDT15metabolic status influences drug selection and dosing.	3	{"Latino": 0.00033617634, "European": 0.0002236386, "East Asian": 0.000113386974, "Near Eastern": 0.0, "Central/South Asian": 0.000042878622, "Sub-Saharan African": 0.0026164071, "African American/Afro-Caribbean": 0.0029308118}
6592980	TPMT	Normal Metabolizer	n/a	Normal/Routine/Low Risk	This result signifies that the patient has two copies of a normal function allele. Based on the genotype result this patient is predicted to be a TPMT normal metabolizer. There is no reason to selectively adjust the dose of most medications that are metabolized by TPMT. However, thiopurines can be affected by a patient's TPMT and NUDT15 phenotype. Please consult a clinical pharmacist for more information about how TPMT and NUDT15 metabolic status influences drug selection and dosing.	3	{"Latino": 0.890108, "European": 0.9090313, "East Asian": 0.9596651, "Near Eastern": 0.93240434, "Central/South Asian": 0.96308726, "Sub-Saharan African": 0.8491466, "African American/Afro-Caribbean": 0.8526922}
6592983	TPMT	Intermediate Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a normal function allele and one copy of a no function allele. Based on the genotype result this patient is predicted to be a TPMT intermediate metabolizer. This patient may be at risk for an adverse reactions to medications that are metabolized by TPMT (eg. thiopurines). To avoid an untoward drug response, dose adjustments or alternative therapeutic agents may be necessary for medications metabolized by TPMT. However, thiopurines can be affected by a patient's TPMT and NUDT15 phenotype. Please consult a clinical pharmacist for more information about how TPMT and NUDT15 metabolic status influences drug selection and dosing.	3	{"Latino": 0.100754894, "European": 0.083957225, "East Asian": 0.033404876, "Near Eastern": 0.06641302, "Central/South Asian": 0.034146916, "Sub-Saharan African": 0.1004582, "African American/Afro-Caribbean": 0.068898946}
6592996	TPMT	Poor Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has two copies of a no function allele. Based on the genotype result this patient is predicted to be a TPMT poor metabolizer. This patient may be at a high risk for an adverse reactions to medications that are metabolized by TPMT (eg. thiopurines). To avoid an untoward drug response, dose adjustments or or alternative therapy may be necessary for medications metabolized by TPMT. However, thiopurines can be affected by a patient's TPMT and NUDT15 phenotype. Please consult a clinical pharmacist for more information about how TPMT and NUDT16 metabolic status influences drug selection and dosing.	3	{"Latino": 0.0028512129, "European": 0.0019385515, "East Asian": 0.00029069668, "Near Eastern": 0.0011826118, "Central/South Asian": 0.00030267553, "Sub-Saharan African": 0.002971174, "African American/Afro-Caribbean": 0.0013917874}
6593064	TPMT	Indeterminate	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has an allele combination with uncertain and/or unknown function alleles. The expected phenotype for this patient cannot be determined currently based on the TPMT diplotype result. Consider evaluating TPMT erythrocyte activity to assess TPMT phenotype. Erythrocyte TPMT activity test results can be falsely low at diagnosis of leukemia and is unreliable in the case of recent red blood cell transfusions. If thiopurines are required and TPMT status is unknown, monitor closely for toxicity. Please consult a clinical pharmacist for more specific information about how TPMT function influences drug dosing.	3	{"Latino": 0.0059497347, "European": 0.0048492607, "East Asian": 0.006525885, "Near Eastern": 0.0, "Central/South Asian": 0.0024202352, "Sub-Saharan African": 0.044807594, "African American/Afro-Caribbean": 0.07408627}
6593986	UGT1A1	Indeterminate	n/a	none	This result signifies that the patient has an allele combination with uncertain and/or unknown function alleles. The expected phenotype for this patient cannot be determined currently based on the UGT1A1 diplotype result. UGT1A1*80 is in very high linkage disequilibrium with *28 and *37. In the rare event that *80 is detected but *28 and *37 are not, there are not enough clinical data to predict metabolizer status with certainty. However, if only *80 is interrogated and the patient is heterozygous or homozygous for *80, an intermediate or poor metabolizer phenotype may be inferred, respectively. Please consult a clinical pharmacist for more specific information about how UGT1A1 function influences drug dosing.	2	\N
6593948	UGT1A1	Intermediate Metabolizer	n/a	Normal/Routine/Low Risk	This result signifies that the patient has one copy of a normal function allele (*1) OR one copy of an increased function allele (*36), AND and one copy of a decreased function allele (*_). Based on the genotype result this patient is predicted to be an intermediate metabolizer of UGT1A1 substrates. There is no reason to selectively adjust the dose of most medications that inhibit or are inactivated by UGT1A1. Please consult a clinical pharmacist for more information about how UGT1A1 metabolic status influences drug selection and dosing.	2	\N
6593941	UGT1A1	Normal Metabolizer	n/a	Normal/Routine/Low Risk	This result signifies that the patient has two copies of a normal function allele (*1) OR one copy of a normal function allele (*1) and one copy of an increased function allele (*36) OR two copies of an increased function allele (*36). Based on the genotype result this patient is predicted to be an normal metabolizer of UGT1A1 substrates. There is no reason to selectively adjust the dose of most medications that inhibit or are inactivated by UGT1A1. Please consult a clinical pharmacist for more information about how UGT1A1 metabolic status influences drug selection and dosing.	2	\N
6593963	UGT1A1	Poor Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has two copies of decreased function alleles (*_ and *_). Based on the genotype result this patient is predicted to be a poor metabolizer of UGT1A1 substrates. This patient may be at risk for an adverse or poor response to medications that inhibit or are inactivated by UGT1A1. Based on the genotype result, this patient is predicted to have low UGT1A1 function, which is generally indicative of Gilbert syndrome. This patient may be at high risk for toxicity from select medications that inhibit or are inactivated by UGT1A1. Please consult a clinical pharmacist for more information about how UGT1A1 metabolic status influences drug selection and dosing.	2	\N
6494392	CYP2D6	Ultrarapid Metabolizer	3.0	Abnormal/Priority/High Risk	This result signifies that this patient has [X copies of a normal function allele (*_xN)] [X copies of a decreased function allele (*_)] [X copies of a no function allele (*_)]. Based on the genotype result this patient is predicted to be an ultrarapid metabolizer of CYP2D6 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2D6. To avoid an untoward drug response, dose adjustments may be necessary for medications metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.035694193, "American": 0.048732717, "European": 0.019382542, "Oceanian": 0.16405001, "East Asian": 0.006179998, "Near Eastern": 0.06435209, "Central/South Asian": 0.014773737, "Sub-Saharan African": 0.019435417, "African American/Afro-Caribbean": 0.025694855}
6494384	CYP2D6	Ultrarapid Metabolizer	2.75	Abnormal/Priority/High Risk	This result signifies that this patient has [X copies of a normal function allele (*_xN)] [X copies of a decreased function allele (*_)] [X copies of a no function allele (*_)]. Based on the genotype result this patient is predicted to be an ultrarapid metabolizer of CYP2D6 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2D6. To avoid an untoward drug response, dose adjustments may be necessary for medications metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.0, "American": 0.0, "European": 0.0, "Oceanian": 0.0, "East Asian": 0.0, "Near Eastern": 0.0, "Central/South Asian": 0.0, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": 0.0}
6494490	CYP2D6	Ultrarapid Metabolizer	2.5	Abnormal/Priority/High Risk	This result signifies that this patient has [X copies of a normal function allele (*_xN)] [X copies of a decreased function allele (*_)]. Based on the genotype result this patient is predicted to be an ultrarapid metabolizer of CYP2D6 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2D6. To avoid an untoward drug response, dose adjustments may be necessary for medications metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.0022434974, "American": 0.0005345896, "European": 0.0003203256, "Oceanian": 0.00024761492, "East Asian": 0.00034846712, "Near Eastern": 0.005864233, "Central/South Asian": 0.00006554563, "Sub-Saharan African": 0.015329994, "African American/Afro-Caribbean": 0.01435911}
6494638	CYP2D6	Normal Metabolizer	2.0	Normal/Routine/ Low Risk	This result signifies that this patient has [X copies of a normal function allele (*_xN)] [X copies of a decreased function allele (*_)] [X copies of a no function allele (*_)]. Based on the genotype result this patient is predicted to be a normal metabolizer of CYP2D6 substrates. There is no reason to selectively adjust the dose of most medications that are metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.42007107, "American": 0.57988566, "European": 0.32166475, "Oceanian": 0.48931405, "East Asian": 0.1527359, "Near Eastern": 0.2670007, "Central/South Asian": 0.34187043, "Sub-Saharan African": 0.15406683, "African American/Afro-Caribbean": 0.22171879}
6494931	CYP2D6	Normal Metabolizer	1.75	Normal/Routine/ Low Risk	This result signifies that this patient has three copies of *41 (*41x3) and one copy of a normal function allele (*_) or [2 copies of a decreased function allele with an activity value of 0.5 (*_x2)]. Based on the genotype result this patient is predicted to be a normal metabolizer of CYP2D6 substrates. There is no reason to selectively adjust the dose of most medications that are metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.0, "American": 0.0, "European": 0.0, "Oceanian": 0.0, "East Asian": 0.0, "Near Eastern": 0.0, "Central/South Asian": 0.0, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": 0.0}
6494964	CYP2D6	Intermediate Metabolizer	1.0	Abnormal/Priority/High Risk	This result signifies that this patient has [1 copy of a normal function allele (*_)] [X copies of a decreased function allele (*_)] [X copies of a no function allele (*_)]. Based on the genotype result this patient is predicted to be an intermediate metabolizer of CYP2D6 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2D6. To avoid an untoward drug response, dose adjustments may be necessary for medications metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.2278144, "American": 0.21460281, "European": 0.28533316, "Oceanian": 0.077126324, "East Asian": 0.070599586, "Near Eastern": 0.14959782, "Central/South Asian": 0.17827679, "Sub-Saharan African": 0.20079781, "African American/Afro-Caribbean": 0.2080644}
6496555	CYP2D6	Intermediate Metabolizer	0.5	Abnormal/Priority/High Risk	This result signifies that this patient has [1 copy of a decreased function allele with an activity value of 0.5 (*_)] or [2 copies of a decreased function allele with an activity value of 0.25 (*_x2)] and one copy of a no function allele (*_) OR two copies for a decreased function allele with an activity value of 0.25 (*_/*_). Based on the genotype result this patient is predicted to be an intermediate metabolizer of CYP2D6 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2D6. To avoid an untoward drug response, dose adjustments may be necessary for medications metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.022830304, "American": 0.0047207433, "European": 0.023932345, "Oceanian": 0.008138877, "East Asian": 0.21193053, "Near Eastern": 0.06410619, "Central/South Asian": 0.040293686, "Sub-Saharan African": 0.0954133, "African American/Afro-Caribbean": 0.08539959}
6497248	CYP2D6	Intermediate Metabolizer	0.25	Abnormal/Priority/High Risk	This result signifies that this patient has one copy of a decreased function allele with an activity value of 0.25 (*_) and one copy of a no function allele (*_). Based on the genotype result this patient is predicted to be an intermediate metabolizer of CYP2D6 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2D6. To avoid an untoward drug response, dose adjustments may be necessary for medications metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.03277562, "American": 0.0138169695, "European": 0.07070104, "Oceanian": 0.010012345, "East Asian": 0.08220821, "Near Eastern": 0.06670452, "Central/South Asian": 0.060946763, "Sub-Saharan African": 0.027220901, "African American/Afro-Caribbean": 0.024385082}
6497778	CYP2D6	Poor Metabolizer	0.0	Abnormal/Priority/High Risk	This result signifies that the patient has two copies of a no function allele (*_/*_). Based on the genotype result this patient is predicted to be a poor metabolizer of CYP2D6 substrates. This patient may be at a high risk for an adverse or poor response to medications that are metabolized by CYP2D6. To avoid an untoward drug response, dose adjustments or alternative therapeutic agents may be necessary for medications metabolized by the CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.0311798, "American": 0.020160662, "European": 0.065024786, "Oceanian": 0.0031239481, "East Asian": 0.008123729, "Near Eastern": 0.021957064, "Central/South Asian": 0.023507897, "Sub-Saharan African": 0.020398295, "African American/Afro-Caribbean": 0.023474354}
6594000	HLA-A	*31:01 negative	n/a	Routine/Low-Risk	The HLA-A*31:01 allele, which is associated with severe cutaneous adverse reactions among patients taking certain aromatic anticonvulsants, was not detected in this patient. No change in therapy is warranted based on these results. It should be noted that a negative HLA-A*31:01 result does not absolutely rule out the possibility of an adverse drug reaction. Please consult a clinical pharmacist for more information.	1	\N
6594003	HLA-A	*31:01 positive	n/a	Priority/High-Risk	This result signifies that the patient has one or two copies of HLA-A*31:01. Patients with this genotype are at increased risk of severe cutaneous adverse reactions, including Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN), drug reaction with eosinophilia and systemic symptoms (DRESS), and maculopapular exanthema (MPE), with certain aromatic anticonvulsants (e.g., carbamazepine). Alternative therapy may be warranted. Please consult a clinical pharmacist for more information.	1	\N
6489431	CYP2B6	Intermediate Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a normal function allele and one copy of a no function allele OR one copy of a normal function allele and one copy of a decreased function allele OR one copy of an increased function allele and one copy of a no function allele OR one copy of an increased function allele and one copy of a decreased function allele. Based on the genotype result this patient is predicted to be an intermediate metabolizer of CYP2B6 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2B6. To avoid an untoward drug response, dose adjustments or alternative therapeutic agents may be necessary for medications metabolized by CYP2B6. Please consult a clinical pharmacist for more information about how CYP2B6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.42165288, "European": 0.37952113, "Oceanian": 0.46080005, "East Asian": 0.32628936, "Near Eastern": 0.459102, "Central/South Asian": 0.36526063, "Sub-Saharan African": 0.36808127, "African American/Afro-Caribbean": 0.4660738}
6489408	CYP2B6	Normal Metabolizer	n/a	Normal/Routine/Low Risk	This result signifies that the patient has two copies of normal function alleles. Based on the genotype result this patient is predicted to be an normal metabolizer of CYP2B6 substrates. There is no reason to selectively adjust the dose of most medications that are metabolized by CYP2B6. Please consult a clinical pharmacist for more information about how CYP2B6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.33582056, "European": 0.42950228, "Oceanian": 0.12960002, "East Asian": 0.48562673, "Near Eastern": 0.29052103, "Central/South Asian": 0.42183065, "Sub-Saharan African": 0.14307445, "African American/Afro-Caribbean": 0.333572}
6489400	CYP2B6	Rapid Metabolizer	n/a	Normal/Routine/Low Risk	This result signifies that the patient has one copy of a normal function allele and one copy of an increased function allele. Based on the genotype result this patient is predicted to be a rapid metabolizer of CYP2B6 substrates. There is no reason to selectively adjust the dose of most medications that are metabolized by CYP2B6. Please consult a clinical pharmacist for more information about how CYP2B6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.1231214, "European": 0.05357082, "Oceanian": 0.0, "East Asian": 0.11734093, "Near Eastern": 0.112112, "Central/South Asian": 0.12859802, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": 0.011896482}
6489397	CYP2B6	Ultrarapid Metabolizer	n/a	Normal/Routine/Low Risk	This result signifies that the patient has two copies of increased function alleles. Based on the genotype result this patient is predicted to be an ultrarapid metabolizer of CYP2B6 substrates. There is no reason to selectively adjust the dose of most medications that are metabolized by CYP2B6. Please consult a clinical pharmacist for more information about how CYP2B6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.011284955, "European": 0.0016704409, "Oceanian": 0.0, "East Asian": 0.007088209, "Near Eastern": 0.010816, "Central/South Asian": 0.009801, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": 0.000106068765}
6594006	HLA-B	*15:02 negative	n/a	Routine/Low-Risk	The HLA-B*15:02 allele, which is associated with severe cutaneous adverse reactions among patients taking certain aromatic anticonvulsants, was not detected in this patient. No change in therapy is warranted based on these results. It should be noted that a negative HLA-B*15:02 result does not absolutely rule out the possibility of an adverse drug reaction. Please consult a clinical pharmacist for more information.	1	\N
6594009	HLA-B	*15:02 positive	n/a	Priority/High-Risk	This result signifies that the patient has one or two copies of HLA-B*15:02. Patients with this genotype are at increased risk of severe cutaneous adverse reactions, including Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN), with certain aromatic anticonvulsants (e.g., carbamazepine, oxcarbazepine, phenytoin/fosphenytoin). Alternative therapy may be warranted. Please consult a clinical pharmacist for more information.	1	\N
6594012	HLA-B	*57:01 negative	n/a	Normal/Routine/Low Risk	The HLA-B*57:01 allele, associated with abacavir hypersensitivity, was not detected in this patient. The patient may be prescribed abacavir. Please refer to the hospital formulary guidelines for specific dosing information. It should be noted that a negative HLA-B*57:01 result does not absolutely rule out the possibility of some form of abacavir hypersensitivity. Administration of abacavir therapy requires close observation including immediate discontinuation of therapy should any signs or symptoms of hypersensitivity develop.	1	\N
6594015	HLA-B	*57:01 positive	n/a	Abnormal/Priority/High Risk	The HLA-B*57:01 allele, associated with abacavir hypersensitivity, was detected in this patient. HLA-B*5701 positive patients should NOT be prescribed abacavir.	1	\N
6594018	HLA-B	*58:01 negative	n/a	Normal/Routine/Low Risk	The HLA-B*58:01 allele, associated with allopurinol hypersensitivity, was not detected in this patient. Allopurinol can be used per standard dosing guidelines. Patients should be monitored closely for any signs of sensitivity reactions, especially those patients receiving allopurinol (of >300 mg/day), concomitant medications (i.e. thiazide diuretics or penicillin/cephalosporin) or with medical conditions (i.e. chronic kidney disease) that increase the non-genetic risk for allopurinol-related hypersensitivity reactions.	1	\N
6594021	HLA-B	*58:01 positive	n/a	Abnormal/Priority/High Risk	The HLA-B*58:01 allele, associated with allopurinol hypersensitivity, was detected in this patient. Allopurinol is contraindicated.	1	\N
6489847	CYP2B6	Indeterminate	n/a	none	This result signifies that the patient has an allele combination with uncertain and/or unknown function alleles. The expected phenotype for this patient cannot be determined currently based on the CYP2B6 diplotype result. Please consult a clinical pharmacist for more specific information about how CYP2B6 function influences drug dosing.	3	{"Latino": 0.013596146, "European": 0.06145065, "Oceanian": 0.0, "East Asian": 0.020025712, "Near Eastern": 0.0, "Central/South Asian": 0.014973663, "Sub-Saharan African": 0.25210795, "African American/Afro-Caribbean": 0.031204166}
6490709	CYP2C19	Intermediate Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a normal function allele and one copy of a no function allele OR one copy of an increased function and one copy of a no function allele. Based on the genotype result this patient is predicted to be an intermediate metabolizer of CYP2C19 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2C19. To avoid an untoward drug response, dose adjustments or alternative therapeutic agents may be necessary for medications metabolized by CYP2C19. Please consult a clinical pharmacist for more information about how CYP2C19 metabolic status influences drug selection and dosing.	3	{"Latino": 0.19035932, "American": 0.21383229, "European": 0.26108757, "Oceanian": 0.36902928, "East Asian": 0.45928204, "Near Eastern": 0.2354828, "Central/South Asian": 0.40806636, "Sub-Saharan African": 0.29945874, "African American/Afro-Caribbean": 0.31398684}
6490808	CYP2C19	Likely Poor Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a decreased function allele and one copy of a no function allele. Based on the genotype result this patient MAY be a poor metabolizer of CYP2C19 substrates. This patient may be at a high risk for an adverse or poor response to medications that are metabolized by CYP2C19. To avoid an untoward drug response, dose adjustments or or alternative therapy may be necessary for medications metabolized by the CYP2C19. Please consult a clinical pharmacist for more information about how CYP2C19 metabolic status influences drug selection and dosing.	3	{"Latino": 0.0004440685, "American": 0.0, "European": 0.00020405183, "Oceanian": 0.0, "East Asian": 0.0004349198, "Near Eastern": 0.0, "Central/South Asian": 0.0, "Sub-Saharan African": 0.010332189, "African American/Afro-Caribbean": 0.007090685}
6490606	CYP2C19	Normal Metabolizer	n/a	Normal/Routine/Low Risk	This result signifies that the patient has two copies of a normal function allele. Based on the genotype result this patient is predicted to be an normal metabolizer of CYP2C19 substrates. There is no reason to selectively adjust the dose of most medications that are metabolized by CYP2C19. Please consult a clinical pharmacist for more information about how CYP2C19 metabolic status influences drug selection and dosing.	3	{"Latino": 0.5249766, "American": 0.62755567, "European": 0.39611652, "Oceanian": 0.035006005, "East Asian": 0.38055435, "Near Eastern": 0.45192146, "Central/South Asian": 0.29552925, "Sub-Saharan African": 0.36977687, "African American/Afro-Caribbean": 0.32805592}
6490882	CYP2C19	Poor Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has two copies of a no function allele. Based on the genotype result this patient is predicted to be a poor metabolizer of CYP2C19 substrates. This patient may be at a high risk for an adverse or poor response to medications that are metabolized by CYP2C19. To avoid an untoward drug response, dose adjustments or or alternative therapy may be necessary for medications metabolized by the CYP2C19. Please consult a clinical pharmacist for more information about how CYP2C19 metabolic status influences drug selection and dosing.	3	{"Latino": 0.011408395, "American": 0.014819587, "European": 0.02387743, "Oceanian": 0.5713864, "East Asian": 0.12978691, "Near Eastern": 0.018584846, "Central/South Asian": 0.08156806, "Sub-Saharan African": 0.036714304, "African American/Afro-Caribbean": 0.040512204}
6490594	CYP2C19	Ultrarapid Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has two copies of an increased function allele. Based on the genotype result this patient is predicted to be an ultrarapid metabolizer of CYP2C19 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2C19. To avoid an untoward drug response, dose adjustments or alternative therapeutic agents may be necessary for medications metabolized by CYP2C19. Please consult a clinical pharmacist for more information about how CYP2C19 metabolic status influences drug selection and dosing.	3	{"Latino": 0.02774172, "American": 0.0074097984, "European": 0.04641379, "Oceanian": 0.003249, "East Asian": 0.00042194634, "Near Eastern": 0.036642652, "Central/South Asian": 0.029163336, "Sub-Saharan African": 0.030045323, "African American/Afro-Caribbean": 0.042943195}
6532460	MT-RNR1	increased risk of aminoglycoside-induced hearing loss	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has a copy of the MT-RNR1 [variant]. Based on this genotype result, the patient is predicted to be at increased risk of aminoglycoside-induced hearing loss. This means that the patient is likely to develop irreversible hearing loss if aminoglycosides (e.g. amikacin, gentamicin, tobramycin) are prescribed. Please consult a clinical pharmacist or Infectious Diseases Service for help selecting alternative therapies.	2	\N
6532468	MT-RNR1	uncertain risk of aminoglycoside-induced hearing loss	n/a	Normal/Routine/Low Risk	This result signifies that the patient has a copy of MT-RNR1 [variant]. At this time, the association of this allele with aminoglycoside-induced hearing loss is unknown/uncertain. Based on this genotype result, no change in aminoglycoside therapy is warranted. It should be noted that this result does not absolutely rule out the possibility of the patient developing ototoxicity with aminoglycoside use.	2	\N
6490962	CYP2C19	Indeterminate	n/a	none	This result signifies that the patient has an allele combination with uncertain and/or unknown function alleles. The expected phenotype for this patient cannot be determined currently based on the CYP2C19 diplotype result. Please consult a clinical pharmacist for more specific information about how CYP2C19 function influences drug dosing.	3	{"Latino": 0.0, "American": 0.0, "European": 0.0, "Oceanian": 0.0, "East Asian": 0.0034064606, "Near Eastern": 0.0, "Central/South Asian": 0.0, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": 0.0022393465}
6491332	CYP2C9	Intermediate Metabolizer	1.0	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a normal function allele and one copy of a no function allele OR two copies of decreased function alleles. Based on the genotype result, this patient is predicted to be a CYP2C9 intermediate metabolizer (activity score of 1). This patient may be at risk for an adverse response to medications that are affected by CYP2C9. Please consult a clinical pharmacist for more specific information about how CYP2C9 intermediate metabolizer status influences drug dosing.	3	{"Latino": 0.08109343, "American": 0.05818467, "European": 0.13767911, "Oceanian": 0.03061276, "East Asian": 0.098925985, "Near Eastern": 0.1494271, "Central/South Asian": 0.18352722, "Sub-Saharan African": 0.049747862, "African American/Afro-Caribbean": 0.049812526}
6491592	CYP2C9	Poor Metabolizer	0.5	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a decreased function allele and one copy of a no function allele. Based on the genotype result, this patient is predicted to be a CYP2C9 poor metabolizer. This patient may be at high risk for an adverse response to medications that are affected by CYP2C9. Please consult a clinical pharmacist for more specific information about how CYP2C9 intermediate metabolizer status influences drug dosing.	3	{"Latino": 0.007974847, "American": 0.0034911723, "European": 0.019907156, "Oceanian": 0.0009130932, "East Asian": 0.0030826868, "Near Eastern": 0.022547128, "Central/South Asian": 0.025517693, "Sub-Saharan African": 0.0049882242, "African American/Afro-Caribbean": 0.004712071}
6491867	CYP2C9	Poor Metabolizer	0.0	Abnormal/Priority/High Risk	This result signifies that the patient has two copies of no function alleles. Based on the genotype result, this patient is predicted to be a CYP2C9 poor metabolizer. This patient may be at high risk for an adverse response to medications that are affected by CYP2C9. Please consult a clinical pharmacist for more specific information about how CYP2C9 intermediate metabolizer status influences drug dosing.	3	{"Latino": 0.0017415384, "American": 0.00090327376, "European": 0.0057798154, "Oceanian": 0.00024261088, "East Asian": 0.0028714235, "Near Eastern": 0.007066085, "Central/South Asian": 0.012135133, "Sub-Saharan African": 0.0003982905, "African American/Afro-Caribbean": 0.00048520204}
6483912	ABCG2	Poor Function	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has two copies of a decreased function allele. Based on the genotype result, this patient is predicted to have poor ABCG2 function. This patient may be at a high risk for an adverse response to medications that are affected by ABCG2 (i.e. statins). To avoid an untoward drug response, dose adjustments or alternative therapeutic agents may be necessary for medications affected by ABCG2. Please consult a clinical pharmacist for more specific information about how ABCG2 function influences drug dosing.	3	{"Latino": 0.05035536, "American": 0.040000003, "European": 0.010732961, "Oceanian": 0.0419122, "East Asian": 0.09431041, "Near Eastern": 0.00426409, "Central/South Asian": 0.00868624, "Sub-Saharan African": 0.000034175762, "African American/Afro-Caribbean": 0.0012156549}
6483915	ABCG2	Decreased Function	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a normal function allele and one copy of a no decreased allele . Based on the genotype result, this patient is predicted to have decreased ABCG2 function. This patient may be at risk for an adverse response to medications that are affected by ABCG2. To avoid an untoward drug response, dose adjustments may be necessary for medications affected by ABCG2 (i.e. statins). Please consult a clinical pharmacist for more specific information about how ABCG2 function influences drug dosing.	3	{"Latino": 0.34808928, "American": 0.32000002, "European": 0.18573408, "Oceanian": 0.32562497, "East Asian": 0.4255792, "Near Eastern": 0.122071825, "Central/South Asian": 0.1690275, "Sub-Saharan African": 0.011623656, "African American/Afro-Caribbean": 0.06730118}
6491960	CYP2C9	Indeterminate	n/a	none	This result signifies that the patient has an allele combination with uncertain and/or unknown function alleles. The expected phenotype for this patient cannot be determined currently based on the CYP2C9 diplotype result. Please consult a clinical pharmacist for more specific information about how CYP2C9 function influences drug dosing.	3	{"Latino": 0.0009997501, "American": 0.0, "European": 0.00059991, "Oceanian": 0.0, "East Asian": 0.0046076896, "Near Eastern": 0.0, "Central/South Asian": 0.0037963898, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": 0.0}
6491283	CYP2C9	Normal Metabolizer	2.0	Normal/Routine/Low Risk	This result signifies that the patient has two copies of a normal function allele. Based on the genotype result, this patient is predicted to be a CYP2C9 Normal metabolizer. Based only on the CYP2C9 genotype, there is no reason to adjust the dose of most medications that are affected by CYP2C9. Please consult a clinical pharmacist for more specific information about how CYP2C9 function influences drug dosing.	3	{"Latino": 0.74342215, "American": 0.83149743, "European": 0.62845254, "Oceanian": 0.9122409, "East Asian": 0.8378542, "Near Eastern": 0.61125296, "Central/South Asian": 0.5961676, "Sub-Saharan African": 0.73114437, "African American/Afro-Caribbean": 0.75866354}
6491288	CYP2C9	Intermediate Metabolizer	1.5	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a normal function allele and one copy of a decreased function allele. Based on the genotype result, this patient is predicted to be a CYP2C9 intermediate metabolizer (activity score of 1.5). This patient may be at risk for an adverse response to medications that are affected by CYP2C9. Please consult a clinical pharmacist for more specific information about how CYP2C9 intermediate metabolizer status influences drug dosing.	3	{"Latino": 0.1647683, "American": 0.10592343, "European": 0.20758142, "Oceanian": 0.05599055, "East Asian": 0.052658077, "Near Eastern": 0.2097067, "Central/South Asian": 0.17885593, "Sub-Saharan African": 0.21372117, "African American/Afro-Caribbean": 0.1863267}
\.


--
-- Data for Name: gene_result_diplotype; Type: TABLE DATA; Schema: cpic; Owner: -
--

COPY cpic.gene_result_diplotype (id, functionphenotypeid, diplotype, diplotypekey, frequency) FROM stdin;
6500432	6499734	*1/*75	{"CYP2D6": {"*1": 1, "*75": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": 0.00014818038, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
6500433	6499734	*27/*153	{"CYP2D6": {"*27": 1, "*153": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": 0.0000034884083, "African American/Afro-Caribbean": null}
6500434	6499734	*27/*152	{"CYP2D6": {"*27": 1, "*152": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": 0.0000034884083, "African American/Afro-Caribbean": null}
6500435	6499734	*27/*159	{"CYP2D6": {"*27": 1, "*159": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": 0.0000034884083, "African American/Afro-Caribbean": null}
6500436	6499734	*27/*158	{"CYP2D6": {"*27": 1, "*158": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": 0.000013953633, "African American/Afro-Caribbean": null}
6500437	6499734	*27/*157	{"CYP2D6": {"*27": 1, "*157": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": 0.0000034884083, "African American/Afro-Caribbean": null}
6500438	6499734	*2/*71	{"CYP2D6": {"*2": 1, "*71": 1}}	{"Latino": null, "American": 0.0, "European": 0.0, "Oceanian": 0.005215548, "East Asian": 0.00049331953, "Near Eastern": 0.0, "Central/South Asian": 0.0, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": 0.0}
6500439	6499734	*2/*70	{"CYP2D6": {"*2": 1, "*70": 1}}	{"Latino": null, "American": null, "European": 0.0, "Oceanian": null, "East Asian": 0.0, "Near Eastern": 0.0, "Central/South Asian": null, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": null}
6500440	6499734	*27/*155	{"CYP2D6": {"*27": 1, "*155": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": 0.0000069768166, "African American/Afro-Caribbean": null}
6500441	6499734	*2/*73	{"CYP2D6": {"*2": 1, "*73": 1}}	{"Latino": null, "American": 0.0, "European": 0.0, "Oceanian": null, "East Asian": 0.0, "Near Eastern": 0.0, "Central/South Asian": 0.0, "Sub-Saharan African": 0.00079068117, "African American/Afro-Caribbean": 0.0}
6500442	6499734	*1/*83	{"CYP2D6": {"*1": 1, "*83": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
6500443	6499734	*27/*154	{"CYP2D6": {"*27": 1, "*154": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": 0.0000034884083, "African American/Afro-Caribbean": null}
6500444	6499734	*2/*72	{"CYP2D6": {"*2": 1, "*72": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
6500445	6499734	*1/*82	{"CYP2D6": {"*1": 1, "*82": 1}}	{"Latino": 0.015311215, "American": 0.009729411, "European": 0.0, "Oceanian": null, "East Asian": 0.0, "Near Eastern": 0.0, "Central/South Asian": 0.00052543177, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": 0.0}
6500446	6499734	*2/*75	{"CYP2D6": {"*2": 1, "*75": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": 0.00006965038, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
6500447	6499734	*1/*85	{"CYP2D6": {"*1": 1, "*85": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": 0.0, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
6500448	6499734	*2/*74	{"CYP2D6": {"*2": 1, "*74": 1}}	{"Latino": null, "American": 0.0, "European": 0.0, "Oceanian": null, "East Asian": 0.0, "Near Eastern": 0.0, "Central/South Asian": 0.0, "Sub-Saharan African": 0.00047685142, "African American/Afro-Caribbean": 0.0}
6511063	6511061	*1/*6	{"CYP3A5": {"*1": 1, "*6": 1}}	{"Latino": 0.0128053, "European": 0.00022445525, "East Asian": 0.00033252715, "Near Eastern": 0.009288459, "Central/South Asian": 0.0, "Sub-Saharan African": 0.18527767, "African American/Afro-Caribbean": 0.10068418}
6511069	6511066	*7/*7	{"CYP3A5": {"*7": 2}}	{"Latino": 0.0006259178, "European": 0.0, "East Asian": 0.0, "Near Eastern": 0.000014861411, "Central/South Asian": null, "Sub-Saharan African": 0.00746671, "African American/Afro-Caribbean": 0.0144}
6511070	6511066	*6/*7	{"CYP3A5": {"*6": 1, "*7": 1}}	{"Latino": 0.0018540601, "European": 0.0, "East Asian": 0.0, "Near Eastern": 0.00029364365, "Central/South Asian": null, "Sub-Saharan African": 0.033395033, "African American/Afro-Caribbean": 0.026679855}
6511083	6511078	*3/*8	{"CYP3A5": {"*3": 1, "*8": 1}}	{"Latino": null, "European": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
6511080	6511078	*6/*8	{"CYP3A5": {"*6": 1, "*8": 1}}	{"Latino": null, "European": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
6511081	6511078	*7/*9	{"CYP3A5": {"*7": 1, "*9": 1}}	{"Latino": null, "European": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
6511088	6511085	*8/*9	{"CYP3A5": {"*8": 1, "*9": 1}}	{"Latino": null, "European": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
6511091	6511090	c.496A>G/c.2194G>A (*6)	{"DPYD": {"c.496A>G": 1, "c.2194G>A (*6)": 1}}	\N
6511092	6511090	c.1349C>T/c.1358C>G	{"DPYD": {"c.1349C>T": 1, "c.1358C>G": 1}}	\N
6511093	6511090	c.1218G>A/c.1519G>A	{"DPYD": {"c.1218G>A": 1, "c.1519G>A": 1}}	\N
6511094	6511090	c.1218G>A/c.1990G>T	{"DPYD": {"c.1218G>A": 1, "c.1990G>T": 1}}	\N
6511095	6511090	c.1519G>A/c.2582A>G	{"DPYD": {"c.1519G>A": 1, "c.2582A>G": 1}}	\N
6511096	6511090	c.1990G>T/c.2582A>G	{"DPYD": {"c.1990G>T": 1, "c.2582A>G": 1}}	\N
6511097	6511090	c.1519G>A/c.1615G>A	{"DPYD": {"c.1519G>A": 1, "c.1615G>A": 1}}	\N
6511098	6511090	c.2186C>T/c.2656C>T	{"DPYD": {"c.2186C>T": 1, "c.2656C>T": 1}}	\N
6511099	6511090	c.343A>G/c.2921A>T	{"DPYD": {"c.343A>G": 1, "c.2921A>T": 1}}	\N
6511100	6511090	c.1682G>T/c.3049G>A	{"DPYD": {"c.1682G>T": 1, "c.3049G>A": 1}}	\N
6511101	6511090	c.85T>C (*9A)/c.1358C>G	{"DPYD": {"c.1358C>G": 1, "c.85T>C (*9A)": 1}}	\N
6511102	6511090	c.2194G>A (*6)/c.2978T>G	{"DPYD": {"c.2978T>G": 1, "c.2194G>A (*6)": 1}}	\N
6511103	6511090	c.1349C>T/c.1682G>T	{"DPYD": {"c.1349C>T": 1, "c.1682G>T": 1}}	\N
6511104	6511090	c.1682G>T/c.1906A>C	{"DPYD": {"c.1682G>T": 1, "c.1906A>C": 1}}	\N
6511105	6511090	c.1181G>T/c.2303C>A	{"DPYD": {"c.1181G>T": 1, "c.2303C>A": 1}}	\N
6511106	6511090	c.343A>G/c.1519G>A	{"DPYD": {"c.343A>G": 1, "c.1519G>A": 1}}	\N
6511107	6511090	c.85T>C (*9A)/c.1682G>T	{"DPYD": {"c.1682G>T": 1, "c.85T>C (*9A)": 1}}	\N
6511108	6511090	c.343A>G/c.1990G>T	{"DPYD": {"c.343A>G": 1, "c.1990G>T": 1}}	\N
6511109	6511090	c.967G>A/c.2482G>A	{"DPYD": {"c.967G>A": 1, "c.2482G>A": 1}}	\N
6511110	6511090	c.1260T>A/c.2921A>T	{"DPYD": {"c.1260T>A": 1, "c.2921A>T": 1}}	\N
6511111	6511090	c.3061G>C/Reference	{"DPYD": {"Reference": 1, "c.3061G>C": 1}}	\N
6511112	6511090	c.2161G>A/c.2186C>T	{"DPYD": {"c.2161G>A": 1, "c.2186C>T": 1}}	\N
6511113	6511090	c.2336C>A/c.2977C>T	{"DPYD": {"c.2336C>A": 1, "c.2977C>T": 1}}	\N
6511114	6511090	c.1218G>A/c.2921A>T	{"DPYD": {"c.1218G>A": 1, "c.2921A>T": 1}}	\N
6511115	6511090	c.1615G>A/c.2161G>A	{"DPYD": {"c.1615G>A": 1, "c.2161G>A": 1}}	\N
6511116	6511090	c.1180C>T/c.1906A>C	{"DPYD": {"c.1180C>T": 1, "c.1906A>C": 1}}	\N
6511117	6511090	c.967G>A/c.1577C>G	{"DPYD": {"c.967G>A": 1, "c.1577C>G": 1}}	\N
6511118	6511090	c.1349C>T/c.3061G>C	{"DPYD": {"c.1349C>T": 1, "c.3061G>C": 1}}	\N
6511119	6511090	c.1278G>T/c.2623A>C	{"DPYD": {"c.1278G>T": 1, "c.2623A>C": 1}}	\N
6511120	6511090	c.1260T>A/c.1519G>A	{"DPYD": {"c.1260T>A": 1, "c.1519G>A": 1}}	\N
6511121	6511090	c.1260T>A/c.1990G>T	{"DPYD": {"c.1260T>A": 1, "c.1990G>T": 1}}	\N
6511122	6511090	c.313G>A/c.2336C>A	{"DPYD": {"c.313G>A": 1, "c.2336C>A": 1}}	\N
6511123	6511090	c.498G>A/c.1403C>A	{"DPYD": {"c.498G>A": 1, "c.1403C>A": 1}}	\N
6511124	6511090	c.1403C>A/c.2194G>A (*6)	{"DPYD": {"c.1403C>A": 1, "c.2194G>A (*6)": 1}}	\N
6511125	6511090	c.1278G>T/Reference	{"DPYD": {"Reference": 1, "c.1278G>T": 1}}	\N
6511126	6511090	c.1796T>C/c.2656C>T	{"DPYD": {"c.1796T>C": 1, "c.2656C>T": 1}}	\N
6511127	6511090	c.1615G>A/c.1796T>C	{"DPYD": {"c.1615G>A": 1, "c.1796T>C": 1}}	\N
6511128	6511090	c.775A>G/c.2186C>T	{"DPYD": {"c.775A>G": 1, "c.2186C>T": 1}}	\N
6511129	6511090	c.85T>C (*9A)/c.3061G>C	{"DPYD": {"c.3061G>C": 1, "c.85T>C (*9A)": 1}}	\N
6511130	6511090	c.85T>C (*9A)/c.2161G>A	{"DPYD": {"c.2161G>A": 1, "c.85T>C (*9A)": 1}}	\N
6511131	6511090	c.929T>C/c.1403C>A	{"DPYD": {"c.929T>C": 1, "c.1403C>A": 1}}	\N
6511132	6511090	c.1519G>A/c.2195T>G	{"DPYD": {"c.1519G>A": 1, "c.2195T>G": 1}}	\N
6511133	6511090	c.2978T>G/c.2978T>G	{"DPYD": {"c.2978T>G": 2}}	\N
6511134	6511090	c.1108A>G/c.1218G>A	{"DPYD": {"c.1108A>G": 1, "c.1218G>A": 1}}	\N
6511135	6511090	c.2656C>T/Reference	{"DPYD": {"Reference": 1, "c.2656C>T": 1}}	\N
6511136	6511090	c.496A>G/c.1294G>A	{"DPYD": {"c.496A>G": 1, "c.1294G>A": 1}}	\N
6511137	6511090	c.1627A>G (*5)/c.3067C>A	{"DPYD": {"c.3067C>A": 1, "c.1627A>G (*5)": 1}}	\N
6511138	6511090	c.934C>T/c.2656C>T	{"DPYD": {"c.934C>T": 1, "c.2656C>T": 1}}	\N
6511139	6511090	c.343A>G/c.3049G>A	{"DPYD": {"c.343A>G": 1, "c.3049G>A": 1}}	\N
6511140	6511090	c.967G>A/c.1601G>A (*4)	{"DPYD": {"c.967G>A": 1, "c.1601G>A (*4)": 1}}	\N
6511141	6511090	c.1180C>T/c.2194G>A (*6)	{"DPYD": {"c.1180C>T": 1, "c.2194G>A (*6)": 1}}	\N
6511142	6511090	c.1180C>T/c.3049G>A	{"DPYD": {"c.1180C>T": 1, "c.3049G>A": 1}}	\N
6511143	6511090	c.46C>G/c.2656C>T	{"DPYD": {"c.46C>G": 1, "c.2656C>T": 1}}	\N
6511144	6511090	c.1403C>A/c.1906A>C	{"DPYD": {"c.1403C>A": 1, "c.1906A>C": 1}}	\N
6511145	6511090	c.1519G>A/c.1577C>G	{"DPYD": {"c.1519G>A": 1, "c.1577C>G": 1}}	\N
6511146	6511090	c.1218G>A/c.3049G>A	{"DPYD": {"c.1218G>A": 1, "c.3049G>A": 1}}	\N
6511147	6511090	c.1906A>C/c.2186C>T	{"DPYD": {"c.1906A>C": 1, "c.2186C>T": 1}}	\N
6511148	6511090	c.2482G>A/c.2915A>G	{"DPYD": {"c.2482G>A": 1, "c.2915A>G": 1}}	\N
6511149	6511090	c.2921A>T/Reference	{"DPYD": {"Reference": 1, "c.2921A>T": 1}}	\N
6511150	6511090	c.967G>A/c.2582A>G	{"DPYD": {"c.967G>A": 1, "c.2582A>G": 1}}	\N
6511151	6511090	Reference/Reference	{"DPYD": {"Reference": 2}}	\N
6511152	6511090	c.1577C>G/c.2978T>G	{"DPYD": {"c.1577C>G": 1, "c.2978T>G": 1}}	\N
6511153	6511090	c.967G>A/c.1615G>A	{"DPYD": {"c.967G>A": 1, "c.1615G>A": 1}}	\N
6511154	6511090	c.85T>C (*9A)/c.1543G>A	{"DPYD": {"c.1543G>A": 1, "c.85T>C (*9A)": 1}}	\N
6511155	6511090	c.1627A>G (*5)/c.2303C>A	{"DPYD": {"c.2303C>A": 1, "c.1627A>G (*5)": 1}}	\N
6511156	6511090	c.1003G>T (*11)/c.2977C>T	{"DPYD": {"c.2977C>T": 1, "c.1003G>T (*11)": 1}}	\N
6511157	6511090	c.1601G>A (*4)/c.2915A>G	{"DPYD": {"c.2915A>G": 1, "c.1601G>A (*4)": 1}}	\N
6511158	6511090	c.2336C>A/c.3067C>A	{"DPYD": {"c.2336C>A": 1, "c.3067C>A": 1}}	\N
6511159	6511090	c.1990G>T/c.2482G>A	{"DPYD": {"c.1990G>T": 1, "c.2482G>A": 1}}	\N
6511160	6511090	c.1371C>T/c.1896T>C	{"DPYD": {"c.1371C>T": 1, "c.1896T>C": 1}}	\N
6511161	6511090	c.1003G>T (*11)/c.1218G>A	{"DPYD": {"c.1218G>A": 1, "c.1003G>T (*11)": 1}}	\N
6511162	6511090	c.1682G>T/c.2921A>T	{"DPYD": {"c.1682G>T": 1, "c.2921A>T": 1}}	\N
6511163	6511090	c.1615G>A/c.3061G>C	{"DPYD": {"c.1615G>A": 1, "c.3061G>C": 1}}	\N
6511164	6511090	c.343A>G/c.1906A>C	{"DPYD": {"c.343A>G": 1, "c.1906A>C": 1}}	\N
6511165	6511090	c.775A>G/c.929T>C	{"DPYD": {"c.775A>G": 1, "c.929T>C": 1}}	\N
6511166	6511090	c.1349C>T/c.2161G>A	{"DPYD": {"c.1349C>T": 1, "c.2161G>A": 1}}	\N
6511167	6511090	c.1294G>A/c.2977C>T	{"DPYD": {"c.1294G>A": 1, "c.2977C>T": 1}}	\N
6511168	6511090	c.1278G>T/c.1905C>G	{"DPYD": {"c.1278G>T": 1, "c.1905C>G": 1}}	\N
6511169	6511090	c.775A>G/c.1905C>G	{"DPYD": {"c.775A>G": 1, "c.1905C>G": 1}}	\N
6511170	6511090	c.1278G>T/c.1601G>A (*4)	{"DPYD": {"c.1278G>T": 1, "c.1601G>A (*4)": 1}}	\N
6511171	6511090	c.967G>A/c.1181G>T	{"DPYD": {"c.967G>A": 1, "c.1181G>T": 1}}	\N
6511172	6511090	c.343A>G/c.496A>G	{"DPYD": {"c.343A>G": 1, "c.496A>G": 1}}	\N
6511173	6511090	c.967G>A/c.2195T>G	{"DPYD": {"c.967G>A": 1, "c.2195T>G": 1}}	\N
6511174	6511090	c.1627A>G (*5)/c.2977C>T	{"DPYD": {"c.2977C>T": 1, "c.1627A>G (*5)": 1}}	\N
6511175	6511090	c.496A>G/c.775A>G	{"DPYD": {"c.496A>G": 1, "c.775A>G": 1}}	\N
6511176	6511090	c.313G>A/c.2978T>G	{"DPYD": {"c.313G>A": 1, "c.2978T>G": 1}}	\N
6511177	6511090	c.1260T>A/c.3049G>A	{"DPYD": {"c.1260T>A": 1, "c.3049G>A": 1}}	\N
6511178	6511090	c.2195T>G/c.2977C>T	{"DPYD": {"c.2195T>G": 1, "c.2977C>T": 1}}	\N
6511179	6511090	c.46C>G/c.498G>A	{"DPYD": {"c.46C>G": 1, "c.498G>A": 1}}	\N
6511180	6511090	c.1108A>G/c.2977C>T	{"DPYD": {"c.1108A>G": 1, "c.2977C>T": 1}}	\N
6511181	6511090	c.85T>C (*9A)/c.451A>G	{"DPYD": {"c.451A>G": 1, "c.85T>C (*9A)": 1}}	\N
6511182	6511090	c.967G>A/Reference	{"DPYD": {"c.967G>A": 1, "Reference": 1}}	\N
6511183	6511090	c.451A>G/c.1108A>G	{"DPYD": {"c.451A>G": 1, "c.1108A>G": 1}}	\N
6511184	6511090	c.343A>G/c.1294G>A	{"DPYD": {"c.343A>G": 1, "c.1294G>A": 1}}	\N
6511185	6511090	c.1278G>T/c.1896T>C	{"DPYD": {"c.1278G>T": 1, "c.1896T>C": 1}}	\N
6511186	6511090	c.498G>A/c.2303C>A	{"DPYD": {"c.498G>A": 1, "c.2303C>A": 1}}	\N
6511187	6511090	c.2482G>A/c.2978T>G	{"DPYD": {"c.2482G>A": 1, "c.2978T>G": 1}}	\N
6511188	6511090	c.496A>G/c.3049G>A	{"DPYD": {"c.496A>G": 1, "c.3049G>A": 1}}	\N
6511189	6511090	c.2623A>C/c.2915A>G	{"DPYD": {"c.2623A>C": 1, "c.2915A>G": 1}}	\N
6511190	6511090	c.498G>A/c.3067C>A	{"DPYD": {"c.498G>A": 1, "c.3067C>A": 1}}	\N
6511191	6511090	c.1358C>G/c.2656C>T	{"DPYD": {"c.1358C>G": 1, "c.2656C>T": 1}}	\N
6511192	6511090	c.2582A>G/c.2657G>A (*9B)	{"DPYD": {"c.2582A>G": 1, "c.2657G>A (*9B)": 1}}	\N
6511193	6511090	c.1371C>T/c.1905C>G	{"DPYD": {"c.1371C>T": 1, "c.1905C>G": 1}}	\N
6511194	6511090	c.1371C>T/c.2623A>C	{"DPYD": {"c.1371C>T": 1, "c.2623A>C": 1}}	\N
6511195	6511090	c.1543G>A/c.2161G>A	{"DPYD": {"c.1543G>A": 1, "c.2161G>A": 1}}	\N
6511196	6511090	c.451A>G/c.2194G>A (*6)	{"DPYD": {"c.451A>G": 1, "c.2194G>A (*6)": 1}}	\N
6511197	6511090	c.1294G>A/c.1615G>A	{"DPYD": {"c.1294G>A": 1, "c.1615G>A": 1}}	\N
6511198	6511090	c.1294G>A/c.2582A>G	{"DPYD": {"c.1294G>A": 1, "c.2582A>G": 1}}	\N
6511199	6511090	c.1543G>A/c.3061G>C	{"DPYD": {"c.1543G>A": 1, "c.3061G>C": 1}}	\N
6511200	6511090	c.1218G>A/c.1294G>A	{"DPYD": {"c.1218G>A": 1, "c.1294G>A": 1}}	\N
6511201	6511090	c.2978T>G/c.3061G>C	{"DPYD": {"c.2978T>G": 1, "c.3061G>C": 1}}	\N
6511202	6511090	c.1003G>T (*11)/c.1615G>A	{"DPYD": {"c.1615G>A": 1, "c.1003G>T (*11)": 1}}	\N
6511203	6511090	c.1003G>T (*11)/c.2582A>G	{"DPYD": {"c.2582A>G": 1, "c.1003G>T (*11)": 1}}	\N
6511204	6511090	c.1218G>A/c.2656C>T	{"DPYD": {"c.1218G>A": 1, "c.2656C>T": 1}}	\N
6511205	6511090	c.1403C>A/c.1990G>T	{"DPYD": {"c.1403C>A": 1, "c.1990G>T": 1}}	\N
6511206	6511090	c.525G>A/c.1260T>A	{"DPYD": {"c.525G>A": 1, "c.1260T>A": 1}}	\N
6511207	6511090	c.1003G>T (*11)/c.1181G>T	{"DPYD": {"c.1181G>T": 1, "c.1003G>T (*11)": 1}}	\N
6511208	6511090	c.2161G>A/c.2623A>C	{"DPYD": {"c.2161G>A": 1, "c.2623A>C": 1}}	\N
6511209	6511090	c.934C>T/c.2921A>T	{"DPYD": {"c.934C>T": 1, "c.2921A>T": 1}}	\N
6511210	6511090	c.1796T>C/c.2657G>A (*9B)	{"DPYD": {"c.1796T>C": 1, "c.2657G>A (*9B)": 1}}	\N
6511211	6511090	c.2977C>T/c.3061G>C	{"DPYD": {"c.2977C>T": 1, "c.3061G>C": 1}}	\N
6511212	6511090	c.775A>G/c.1180C>T	{"DPYD": {"c.775A>G": 1, "c.1180C>T": 1}}	\N
6511213	6511090	c.967G>A/c.1896T>C	{"DPYD": {"c.967G>A": 1, "c.1896T>C": 1}}	\N
6511214	6511090	c.496A>G/c.1990G>T	{"DPYD": {"c.496A>G": 1, "c.1990G>T": 1}}	\N
6511215	6511090	c.496A>G/c.496A>G	{"DPYD": {"c.496A>G": 2}}	\N
6511216	6511090	c.934C>T/c.1519G>A	{"DPYD": {"c.934C>T": 1, "c.1519G>A": 1}}	\N
6511217	6511090	c.451A>G/c.1906A>C	{"DPYD": {"c.451A>G": 1, "c.1906A>C": 1}}	\N
6511218	6511090	c.775A>G/c.2623A>C	{"DPYD": {"c.775A>G": 1, "c.2623A>C": 1}}	\N
6511219	6511090	c.343A>G/c.775A>G	{"DPYD": {"c.343A>G": 1, "c.775A>G": 1}}	\N
6511220	6511090	c.343A>G/c.498G>A	{"DPYD": {"c.343A>G": 1, "c.498G>A": 1}}	\N
6511221	6511090	c.2161G>A/Reference	{"DPYD": {"Reference": 1, "c.2161G>A": 1}}	\N
6511222	6511090	c.1615G>A/c.2657G>A (*9B)	{"DPYD": {"c.1615G>A": 1, "c.2657G>A (*9B)": 1}}	\N
6511223	6511090	c.1181G>T/c.2977C>T	{"DPYD": {"c.1181G>T": 1, "c.2977C>T": 1}}	\N
6511224	6511090	c.1108A>G/c.1615G>A	{"DPYD": {"c.1108A>G": 1, "c.1615G>A": 1}}	\N
6511225	6511090	c.1796T>C/c.1990G>T	{"DPYD": {"c.1796T>C": 1, "c.1990G>T": 1}}	\N
6511226	6511090	c.62G>A/c.2657G>A (*9B)	{"DPYD": {"c.62G>A": 1, "c.2657G>A (*9B)": 1}}	\N
6511227	6511090	c.1108A>G/c.2582A>G	{"DPYD": {"c.1108A>G": 1, "c.2582A>G": 1}}	\N
6511228	6511090	c.46C>G/c.1990G>T	{"DPYD": {"c.46C>G": 1, "c.1990G>T": 1}}	\N
6511229	6511090	c.1260T>A/c.1294G>A	{"DPYD": {"c.1260T>A": 1, "c.1294G>A": 1}}	\N
6511230	6511090	c.1358C>G/c.1519G>A	{"DPYD": {"c.1358C>G": 1, "c.1519G>A": 1}}	\N
6511231	6511090	c.1260T>A/c.2656C>T	{"DPYD": {"c.1260T>A": 1, "c.2656C>T": 1}}	\N
6511232	6511090	c.1796T>C/c.2921A>T	{"DPYD": {"c.1796T>C": 1, "c.2921A>T": 1}}	\N
6511233	6511090	c.1577C>G/c.2161G>A	{"DPYD": {"c.1577C>G": 1, "c.2161G>A": 1}}	\N
6511234	6511090	c.1108A>G/c.1181G>T	{"DPYD": {"c.1108A>G": 1, "c.1181G>T": 1}}	\N
6511235	6511090	c.2195T>G/c.2195T>G	{"DPYD": {"c.2195T>G": 2}}	\N
6511236	6511090	c.1519G>A/c.1601G>A (*4)	{"DPYD": {"c.1519G>A": 1, "c.1601G>A (*4)": 1}}	\N
6511237	6511090	c.2195T>G/c.2303C>A	{"DPYD": {"c.2195T>G": 1, "c.2303C>A": 1}}	\N
6511238	6511090	c.2195T>G/c.3067C>A	{"DPYD": {"c.2195T>G": 1, "c.3067C>A": 1}}	\N
6511239	6511090	c.1003G>T (*11)/c.2482G>A	{"DPYD": {"c.2482G>A": 1, "c.1003G>T (*11)": 1}}	\N
6511240	6511090	c.451A>G/c.1180C>T	{"DPYD": {"c.451A>G": 1, "c.1180C>T": 1}}	\N
6511241	6511090	c.775A>G/c.1003G>T (*11)	{"DPYD": {"c.775A>G": 1, "c.1003G>T (*11)": 1}}	\N
6511242	6511090	c.1682G>T/c.1990G>T	{"DPYD": {"c.1682G>T": 1, "c.1990G>T": 1}}	\N
6511243	6511090	c.1519G>A/c.2482G>A	{"DPYD": {"c.1519G>A": 1, "c.2482G>A": 1}}	\N
6511244	6511090	c.525G>A/c.1403C>A	{"DPYD": {"c.525G>A": 1, "c.1403C>A": 1}}	\N
6511245	6511090	c.46C>G/c.496A>G	{"DPYD": {"c.46C>G": 1, "c.496A>G": 1}}	\N
6511246	6511090	c.1990G>T/c.2977C>T	{"DPYD": {"c.1990G>T": 1, "c.2977C>T": 1}}	\N
6511247	6511090	c.1615G>A/c.2336C>A	{"DPYD": {"c.1615G>A": 1, "c.2336C>A": 1}}	\N
6511248	6511090	c.525G>A/c.1627A>G (*5)	{"DPYD": {"c.525G>A": 1, "c.1627A>G (*5)": 1}}	\N
6511249	6511090	c.1349C>T/c.1543G>A	{"DPYD": {"c.1349C>T": 1, "c.1543G>A": 1}}	\N
6511250	6511090	c.1896T>C/c.2303C>A	{"DPYD": {"c.1896T>C": 1, "c.2303C>A": 1}}	\N
6511251	6511090	c.1180C>T/c.2921A>T	{"DPYD": {"c.1180C>T": 1, "c.2921A>T": 1}}	\N
6511252	6511090	c.929T>C/c.1260T>A	{"DPYD": {"c.929T>C": 1, "c.1260T>A": 1}}	\N
6511253	6511090	c.1278G>T/c.2186C>T	{"DPYD": {"c.1278G>T": 1, "c.2186C>T": 1}}	\N
6511254	6511090	c.1896T>C/c.2977C>T	{"DPYD": {"c.1896T>C": 1, "c.2977C>T": 1}}	\N
6511255	6511090	c.498G>A/c.2915A>G	{"DPYD": {"c.498G>A": 1, "c.2915A>G": 1}}	\N
6511256	6511090	c.929T>C/c.1627A>G (*5)	{"DPYD": {"c.929T>C": 1, "c.1627A>G (*5)": 1}}	\N
6511257	6511090	c.62G>A/c.1371C>T	{"DPYD": {"c.62G>A": 1, "c.1371C>T": 1}}	\N
6511258	6511090	c.1601G>A (*4)/c.2303C>A	{"DPYD": {"c.2303C>A": 1, "c.1601G>A (*4)": 1}}	\N
6511259	6511090	c.313G>A/c.451A>G	{"DPYD": {"c.313G>A": 1, "c.451A>G": 1}}	\N
6511260	6511090	c.1577C>G/c.2336C>A	{"DPYD": {"c.1577C>G": 1, "c.2336C>A": 1}}	\N
6511261	6511090	c.1294G>A/c.2482G>A	{"DPYD": {"c.1294G>A": 1, "c.2482G>A": 1}}	\N
6511262	6511090	c.1180C>T/c.1294G>A	{"DPYD": {"c.1180C>T": 1, "c.1294G>A": 1}}	\N
6511263	6511090	c.85T>C (*9A)/c.1796T>C	{"DPYD": {"c.1796T>C": 1, "c.85T>C (*9A)": 1}}	\N
6511264	6511090	c.46C>G/c.2194G>A (*6)	{"DPYD": {"c.46C>G": 1, "c.2194G>A (*6)": 1}}	\N
6511265	6511090	c.1278G>T/c.2582A>G	{"DPYD": {"c.1278G>T": 1, "c.2582A>G": 1}}	\N
6511266	6511090	c.451A>G/c.929T>C	{"DPYD": {"c.451A>G": 1, "c.929T>C": 1}}	\N
6511267	6511090	c.1896T>C/c.3067C>A	{"DPYD": {"c.1896T>C": 1, "c.3067C>A": 1}}	\N
6511268	6511090	c.496A>G/c.1906A>C	{"DPYD": {"c.496A>G": 1, "c.1906A>C": 1}}	\N
6511269	6511090	c.1108A>G/c.2482G>A	{"DPYD": {"c.1108A>G": 1, "c.2482G>A": 1}}	\N
6511270	6511090	c.498G>A/c.967G>A	{"DPYD": {"c.498G>A": 1, "c.967G>A": 1}}	\N
6511271	6511090	c.1990G>T/c.2195T>G	{"DPYD": {"c.1990G>T": 1, "c.2195T>G": 1}}	\N
6511272	6511090	c.1180C>T/c.1519G>A	{"DPYD": {"c.1180C>T": 1, "c.1519G>A": 1}}	\N
6511273	6511090	c.1601G>A (*4)/c.3067C>A	{"DPYD": {"c.3067C>A": 1, "c.1601G>A (*4)": 1}}	\N
6511274	6511090	c.1682G>T/c.2194G>A (*6)	{"DPYD": {"c.1682G>T": 1, "c.2194G>A (*6)": 1}}	\N
6511275	6511090	c.1278G>T/c.2482G>A	{"DPYD": {"c.1278G>T": 1, "c.2482G>A": 1}}	\N
6511276	6511090	c.2194G>A (*6)/c.2336C>A	{"DPYD": {"c.2336C>A": 1, "c.2194G>A (*6)": 1}}	\N
6511277	6511090	c.451A>G/c.775A>G	{"DPYD": {"c.451A>G": 1, "c.775A>G": 1}}	\N
6511278	6511090	c.929T>C/c.1218G>A	{"DPYD": {"c.929T>C": 1, "c.1218G>A": 1}}	\N
6511279	6511090	c.1181G>T/c.3067C>A	{"DPYD": {"c.1181G>T": 1, "c.3067C>A": 1}}	\N
6511280	6511090	c.343A>G/c.2656C>T	{"DPYD": {"c.343A>G": 1, "c.2656C>T": 1}}	\N
6511281	6511090	c.775A>G/c.1278G>T	{"DPYD": {"c.775A>G": 1, "c.1278G>T": 1}}	\N
6511282	6511090	c.46C>G/c.1906A>C	{"DPYD": {"c.46C>G": 1, "c.1906A>C": 1}}	\N
6511283	6511090	c.2977C>T/c.2978T>G	{"DPYD": {"c.2977C>T": 1, "c.2978T>G": 1}}	\N
6511284	6511090	c.1349C>T/c.1796T>C	{"DPYD": {"c.1349C>T": 1, "c.1796T>C": 1}}	\N
6511285	6511090	c.1358C>G/c.2921A>T	{"DPYD": {"c.1358C>G": 1, "c.2921A>T": 1}}	\N
6511286	6511090	c.1519G>A/Reference	{"DPYD": {"Reference": 1, "c.1519G>A": 1}}	\N
6511287	6511090	c.1543G>A/c.2657G>A (*9B)	{"DPYD": {"c.1543G>A": 1, "c.2657G>A (*9B)": 1}}	\N
6511288	6511090	c.313G>A/c.1358C>G	{"DPYD": {"c.313G>A": 1, "c.1358C>G": 1}}	\N
6511289	6511090	c.451A>G/c.1905C>G	{"DPYD": {"c.451A>G": 1, "c.1905C>G": 1}}	\N
6511290	6511090	c.1371C>T/c.1615G>A	{"DPYD": {"c.1371C>T": 1, "c.1615G>A": 1}}	\N
6511291	6511090	c.967G>A/c.1218G>A	{"DPYD": {"c.967G>A": 1, "c.1218G>A": 1}}	\N
6511292	6511090	c.1003G>T (*11)/c.1601G>A (*4)	{"DPYD": {"c.1601G>A (*4)": 1, "c.1003G>T (*11)": 1}}	\N
6511293	6511090	c.525G>A/c.1218G>A	{"DPYD": {"c.525G>A": 1, "c.1218G>A": 1}}	\N
6511294	6511090	c.1371C>T/c.2582A>G	{"DPYD": {"c.1371C>T": 1, "c.2582A>G": 1}}	\N
6511295	6511090	c.1577C>G/c.2657G>A (*9B)	{"DPYD": {"c.1577C>G": 1, "c.2657G>A (*9B)": 1}}	\N
6511296	6511090	c.1294G>A/c.1403C>A	{"DPYD": {"c.1294G>A": 1, "c.1403C>A": 1}}	\N
6511297	6511090	c.46C>G/c.1796T>C	{"DPYD": {"c.46C>G": 1, "c.1796T>C": 1}}	\N
6511298	6511090	c.775A>G/c.2482G>A	{"DPYD": {"c.775A>G": 1, "c.2482G>A": 1}}	\N
6511299	6511090	c.496A>G/c.2186C>T	{"DPYD": {"c.496A>G": 1, "c.2186C>T": 1}}	\N
6511300	6511090	c.1180C>T/c.2186C>T	{"DPYD": {"c.1180C>T": 1, "c.2186C>T": 1}}	\N
6511301	6511090	c.62G>A/c.3049G>A	{"DPYD": {"c.62G>A": 1, "c.3049G>A": 1}}	\N
6511302	6511090	c.451A>G/c.496A>G	{"DPYD": {"c.451A>G": 1, "c.496A>G": 1}}	\N
6511303	6511090	c.525G>A/c.967G>A	{"DPYD": {"c.525G>A": 1, "c.967G>A": 1}}	\N
6511304	6511090	c.1796T>C/c.1906A>C	{"DPYD": {"c.1796T>C": 1, "c.1906A>C": 1}}	\N
6511305	6511090	c.967G>A/c.2977C>T	{"DPYD": {"c.967G>A": 1, "c.2977C>T": 1}}	\N
6511306	6511090	c.2186C>T/c.2194G>A (*6)	{"DPYD": {"c.2186C>T": 1, "c.2194G>A (*6)": 1}}	\N
6511307	6511090	c.2915A>G/c.3049G>A	{"DPYD": {"c.2915A>G": 1, "c.3049G>A": 1}}	\N
6511308	6511090	c.451A>G/c.1003G>T (*11)	{"DPYD": {"c.451A>G": 1, "c.1003G>T (*11)": 1}}	\N
6511309	6511090	c.929T>C/c.967G>A	{"DPYD": {"c.929T>C": 1, "c.967G>A": 1}}	\N
6511310	6511090	c.1181G>T/c.1349C>T	{"DPYD": {"c.1181G>T": 1, "c.1349C>T": 1}}	\N
6511311	6511090	c.498G>A/c.1627A>G (*5)	{"DPYD": {"c.498G>A": 1, "c.1627A>G (*5)": 1}}	\N
6511312	6511090	c.85T>C (*9A)/c.498G>A	{"DPYD": {"c.498G>A": 1, "c.85T>C (*9A)": 1}}	\N
6511313	6511090	c.1358C>G/c.3049G>A	{"DPYD": {"c.1358C>G": 1, "c.3049G>A": 1}}	\N
6511314	6511090	c.1358C>G/c.2194G>A (*6)	{"DPYD": {"c.1358C>G": 1, "c.2194G>A (*6)": 1}}	\N
6511315	6511090	c.2303C>A/Reference	{"DPYD": {"Reference": 1, "c.2303C>A": 1}}	\N
6511316	6511090	c.62G>A/c.1358C>G	{"DPYD": {"c.62G>A": 1, "c.1358C>G": 1}}	\N
6511317	6511090	c.451A>G/c.1519G>A	{"DPYD": {"c.451A>G": 1, "c.1519G>A": 1}}	\N
6511318	6511090	c.1796T>C/c.3049G>A	{"DPYD": {"c.1796T>C": 1, "c.3049G>A": 1}}	\N
6511319	6511090	c.2336C>A/c.2582A>G	{"DPYD": {"c.2336C>A": 1, "c.2582A>G": 1}}	\N
6511320	6511090	c.1905C>G/c.1905C>G	{"DPYD": {"c.1905C>G": 2}}	\N
6511321	6511090	c.62G>A/c.1543G>A	{"DPYD": {"c.62G>A": 1, "c.1543G>A": 1}}	\N
6511322	6511090	c.1906A>C/c.2482G>A	{"DPYD": {"c.1906A>C": 1, "c.2482G>A": 1}}	\N
6511323	6511090	c.2623A>C/c.3067C>A	{"DPYD": {"c.2623A>C": 1, "c.3067C>A": 1}}	\N
6511324	6511090	c.1108A>G/c.1577C>G	{"DPYD": {"c.1108A>G": 1, "c.1577C>G": 1}}	\N
6511325	6511090	c.2303C>A/c.2921A>T	{"DPYD": {"c.2303C>A": 1, "c.2921A>T": 1}}	\N
6511326	6511090	c.525G>A/c.2977C>T	{"DPYD": {"c.525G>A": 1, "c.2977C>T": 1}}	\N
6511327	6511090	c.1519G>A/c.3067C>A	{"DPYD": {"c.1519G>A": 1, "c.3067C>A": 1}}	\N
6511328	6511090	c.1218G>A/c.2657G>A (*9B)	{"DPYD": {"c.1218G>A": 1, "c.2657G>A (*9B)": 1}}	\N
6511329	6511090	c.775A>G/c.2194G>A (*6)	{"DPYD": {"c.775A>G": 1, "c.2194G>A (*6)": 1}}	\N
6511330	6511090	c.934C>T/c.2161G>A	{"DPYD": {"c.934C>T": 1, "c.2161G>A": 1}}	\N
6511331	6511090	c.343A>G/c.929T>C	{"DPYD": {"c.343A>G": 1, "c.929T>C": 1}}	\N
6511332	6511090	c.1519G>A/c.2303C>A	{"DPYD": {"c.1519G>A": 1, "c.2303C>A": 1}}	\N
6511333	6511090	c.62G>A/c.1990G>T	{"DPYD": {"c.62G>A": 1, "c.1990G>T": 1}}	\N
6511334	6511090	c.313G>A/c.1371C>T	{"DPYD": {"c.313G>A": 1, "c.1371C>T": 1}}	\N
6511335	6511090	c.775A>G/c.1577C>G	{"DPYD": {"c.775A>G": 1, "c.1577C>G": 1}}	\N
6511336	6511090	c.967G>A/c.967G>A	{"DPYD": {"c.967G>A": 2}}	\N
6511337	6511090	c.313G>A/c.2161G>A	{"DPYD": {"c.313G>A": 1, "c.2161G>A": 1}}	\N
6511338	6511090	c.1108A>G/c.1403C>A	{"DPYD": {"c.1108A>G": 1, "c.1403C>A": 1}}	\N
6511339	6511090	c.1180C>T/c.1180C>T	{"DPYD": {"c.1180C>T": 2}}	\N
6511340	6511090	c.343A>G/c.1108A>G	{"DPYD": {"c.343A>G": 1, "c.1108A>G": 1}}	\N
6511341	6511090	c.46C>G/c.2657G>A (*9B)	{"DPYD": {"c.46C>G": 1, "c.2657G>A (*9B)": 1}}	\N
6511342	6511090	c.1003G>T (*11)/c.2623A>C	{"DPYD": {"c.2623A>C": 1, "c.1003G>T (*11)": 1}}	\N
6511343	6511090	c.1577C>G/c.1796T>C	{"DPYD": {"c.1577C>G": 1, "c.1796T>C": 1}}	\N
6511344	6511090	c.2161G>A/c.2582A>G	{"DPYD": {"c.2161G>A": 1, "c.2582A>G": 1}}	\N
6511345	6511090	c.929T>C/c.2977C>T	{"DPYD": {"c.929T>C": 1, "c.2977C>T": 1}}	\N
6511346	6511090	c.1349C>T/c.2915A>G	{"DPYD": {"c.1349C>T": 1, "c.2915A>G": 1}}	\N
6511347	6511090	c.1278G>T/c.2195T>G	{"DPYD": {"c.1278G>T": 1, "c.2195T>G": 1}}	\N
6511348	6511090	c.498G>A/c.1260T>A	{"DPYD": {"c.498G>A": 1, "c.1260T>A": 1}}	\N
6511349	6511090	c.775A>G/c.2195T>G	{"DPYD": {"c.775A>G": 1, "c.2195T>G": 1}}	\N
6511350	6511090	c.1003G>T (*11)/c.2303C>A	{"DPYD": {"c.2303C>A": 1, "c.1003G>T (*11)": 1}}	\N
6511351	6511090	c.1180C>T/c.2656C>T	{"DPYD": {"c.1180C>T": 1, "c.2656C>T": 1}}	\N
6511352	6511090	c.775A>G/c.3049G>A	{"DPYD": {"c.775A>G": 1, "c.3049G>A": 1}}	\N
6511353	6511090	c.85T>C (*9A)/c.1260T>A	{"DPYD": {"c.1260T>A": 1, "c.85T>C (*9A)": 1}}	\N
6511354	6511090	c.967G>A/c.1003G>T (*11)	{"DPYD": {"c.967G>A": 1, "c.1003G>T (*11)": 1}}	\N
6511355	6511090	c.1294G>A/c.1896T>C	{"DPYD": {"c.1294G>A": 1, "c.1896T>C": 1}}	\N
6511356	6511090	c.313G>A/c.2915A>G	{"DPYD": {"c.313G>A": 1, "c.2915A>G": 1}}	\N
6511357	6511090	c.451A>G/c.1990G>T	{"DPYD": {"c.451A>G": 1, "c.1990G>T": 1}}	\N
6511358	6511090	c.1003G>T (*11)/c.1905C>G	{"DPYD": {"c.1905C>G": 1, "c.1003G>T (*11)": 1}}	\N
6511359	6511090	c.1278G>T/c.1615G>A	{"DPYD": {"c.1278G>T": 1, "c.1615G>A": 1}}	\N
6511360	6511090	c.62G>A/c.496A>G	{"DPYD": {"c.62G>A": 1, "c.496A>G": 1}}	\N
6511361	6511090	c.46C>G/c.3049G>A	{"DPYD": {"c.46C>G": 1, "c.3049G>A": 1}}	\N
6511362	6511090	c.775A>G/c.934C>T	{"DPYD": {"c.775A>G": 1, "c.934C>T": 1}}	\N
6511363	6511090	c.1108A>G/c.1896T>C	{"DPYD": {"c.1108A>G": 1, "c.1896T>C": 1}}	\N
6511364	6511090	c.62G>A/c.1906A>C	{"DPYD": {"c.62G>A": 1, "c.1906A>C": 1}}	\N
6511365	6511090	c.1181G>T/c.1577C>G	{"DPYD": {"c.1181G>T": 1, "c.1577C>G": 1}}	\N
6511366	6511090	c.1990G>T/c.2186C>T	{"DPYD": {"c.1990G>T": 1, "c.2186C>T": 1}}	\N
6511367	6511090	c.1358C>G/c.1682G>T	{"DPYD": {"c.1358C>G": 1, "c.1682G>T": 1}}	\N
6511368	6511090	c.2194G>A (*6)/c.3061G>C	{"DPYD": {"c.3061G>C": 1, "c.2194G>A (*6)": 1}}	\N
6511369	6511090	c.2195T>G/c.2623A>C	{"DPYD": {"c.2195T>G": 1, "c.2623A>C": 1}}	\N
6511370	6511090	c.2623A>C/c.2978T>G	{"DPYD": {"c.2623A>C": 1, "c.2978T>G": 1}}	\N
6511371	6511090	c.496A>G/c.929T>C	{"DPYD": {"c.496A>G": 1, "c.929T>C": 1}}	\N
6511372	6511090	c.1403C>A/c.2656C>T	{"DPYD": {"c.1403C>A": 1, "c.2656C>T": 1}}	\N
6511373	6511090	c.2186C>T/c.2657G>A (*9B)	{"DPYD": {"c.2186C>T": 1, "c.2657G>A (*9B)": 1}}	\N
6511374	6511090	c.1615G>A/c.2915A>G	{"DPYD": {"c.1615G>A": 1, "c.2915A>G": 1}}	\N
6511375	6511090	c.451A>G/Reference	{"DPYD": {"c.451A>G": 1, "Reference": 1}}	\N
6511376	6511090	c.1543G>A/c.2921A>T	{"DPYD": {"c.1543G>A": 1, "c.2921A>T": 1}}	\N
6511377	6511090	c.934C>T/c.3049G>A	{"DPYD": {"c.934C>T": 1, "c.3049G>A": 1}}	\N
6511378	6511090	c.498G>A/c.1181G>T	{"DPYD": {"c.498G>A": 1, "c.1181G>T": 1}}	\N
6511379	6511090	c.1358C>G/c.2657G>A (*9B)	{"DPYD": {"c.1358C>G": 1, "c.2657G>A (*9B)": 1}}	\N
6511380	6511090	c.1519G>A/c.1905C>G	{"DPYD": {"c.1519G>A": 1, "c.1905C>G": 1}}	\N
6511381	6511090	c.2582A>G/c.2656C>T	{"DPYD": {"c.2582A>G": 1, "c.2656C>T": 1}}	\N
6511382	6511090	c.496A>G/c.1905C>G	{"DPYD": {"c.496A>G": 1, "c.1905C>G": 1}}	\N
6511383	6511090	c.1519G>A/c.2623A>C	{"DPYD": {"c.1519G>A": 1, "c.2623A>C": 1}}	\N
6511384	6511090	c.1627A>G (*5)/c.1627A>G (*5)	{"DPYD": {"c.1627A>G (*5)": 2}}	\N
6511385	6511090	c.1349C>T/c.1349C>T	{"DPYD": {"c.1349C>T": 2}}	\N
6511386	6511090	c.1218G>A/c.2161G>A	{"DPYD": {"c.1218G>A": 1, "c.2161G>A": 1}}	\N
6511387	6511090	c.1905C>G/c.3049G>A	{"DPYD": {"c.1905C>G": 1, "c.3049G>A": 1}}	\N
6511388	6511090	c.498G>A/c.2582A>G	{"DPYD": {"c.498G>A": 1, "c.2582A>G": 1}}	\N
6511389	6511090	c.451A>G/c.2186C>T	{"DPYD": {"c.451A>G": 1, "c.2186C>T": 1}}	\N
6511390	6511090	c.2482G>A/c.3067C>A	{"DPYD": {"c.2482G>A": 1, "c.3067C>A": 1}}	\N
6511391	6511090	c.2657G>A (*9B)/c.2921A>T	{"DPYD": {"c.2921A>T": 1, "c.2657G>A (*9B)": 1}}	\N
6511392	6511090	c.2194G>A (*6)/c.2915A>G	{"DPYD": {"c.2915A>G": 1, "c.2194G>A (*6)": 1}}	\N
6511393	6511090	c.2482G>A/c.2657G>A (*9B)	{"DPYD": {"c.2482G>A": 1, "c.2657G>A (*9B)": 1}}	\N
6511394	6511090	c.1349C>T/c.2657G>A (*9B)	{"DPYD": {"c.1349C>T": 1, "c.2657G>A (*9B)": 1}}	\N
6511395	6511090	c.313G>A/c.1627A>G (*5)	{"DPYD": {"c.313G>A": 1, "c.1627A>G (*5)": 1}}	\N
6511396	6511090	c.1181G>T/c.1218G>A	{"DPYD": {"c.1181G>T": 1, "c.1218G>A": 1}}	\N
6511397	6511090	c.3049G>A/c.3067C>A	{"DPYD": {"c.3049G>A": 1, "c.3067C>A": 1}}	\N
6511398	6511090	c.1003G>T (*11)/c.3067C>A	{"DPYD": {"c.3067C>A": 1, "c.1003G>T (*11)": 1}}	\N
6511399	6511090	c.1601G>A (*4)/c.1682G>T	{"DPYD": {"c.1682G>T": 1, "c.1601G>A (*4)": 1}}	\N
6511400	6511090	c.1627A>G (*5)/Reference	{"DPYD": {"Reference": 1, "c.1627A>G (*5)": 1}}	\N
6511401	6511090	c.1543G>A/c.1627A>G (*5)	{"DPYD": {"c.1543G>A": 1, "c.1627A>G (*5)": 1}}	\N
6511402	6511090	c.313G>A/c.3061G>C	{"DPYD": {"c.313G>A": 1, "c.3061G>C": 1}}	\N
6511403	6511090	c.46C>G/c.1543G>A	{"DPYD": {"c.46C>G": 1, "c.1543G>A": 1}}	\N
6511404	6511090	c.1615G>A/c.2921A>T	{"DPYD": {"c.1615G>A": 1, "c.2921A>T": 1}}	\N
6511405	6511090	c.496A>G/c.1519G>A	{"DPYD": {"c.496A>G": 1, "c.1519G>A": 1}}	\N
6511406	6511090	c.775A>G/c.1108A>G	{"DPYD": {"c.775A>G": 1, "c.1108A>G": 1}}	\N
6511407	6511090	c.1181G>T/c.2482G>A	{"DPYD": {"c.1181G>T": 1, "c.2482G>A": 1}}	\N
6511408	6511090	c.2582A>G/c.3049G>A	{"DPYD": {"c.2582A>G": 1, "c.3049G>A": 1}}	\N
6511409	6511090	c.496A>G/c.2921A>T	{"DPYD": {"c.496A>G": 1, "c.2921A>T": 1}}	\N
6511410	6511090	c.1260T>A/c.2161G>A	{"DPYD": {"c.1260T>A": 1, "c.2161G>A": 1}}	\N
6511411	6511090	c.1180C>T/c.1990G>T	{"DPYD": {"c.1180C>T": 1, "c.1990G>T": 1}}	\N
6511412	6511090	c.1278G>T/c.2194G>A (*6)	{"DPYD": {"c.1278G>T": 1, "c.2194G>A (*6)": 1}}	\N
6511413	6511090	c.2161G>A/c.2921A>T	{"DPYD": {"c.2161G>A": 1, "c.2921A>T": 1}}	\N
6511414	6511090	c.1003G>T (*11)/c.2195T>G	{"DPYD": {"c.2195T>G": 1, "c.1003G>T (*11)": 1}}	\N
6511415	6511090	c.343A>G/c.2194G>A (*6)	{"DPYD": {"c.343A>G": 1, "c.2194G>A (*6)": 1}}	\N
6511416	6511090	c.1905C>G/c.2194G>A (*6)	{"DPYD": {"c.1905C>G": 1, "c.2194G>A (*6)": 1}}	\N
6511417	6511090	c.85T>C (*9A)/c.2336C>A	{"DPYD": {"c.2336C>A": 1, "c.85T>C (*9A)": 1}}	\N
6511418	6511090	c.1615G>A/c.1627A>G (*5)	{"DPYD": {"c.1615G>A": 1, "c.1627A>G (*5)": 1}}	\N
6511419	6511090	c.85T>C (*9A)/c.2921A>T	{"DPYD": {"c.2921A>T": 1, "c.85T>C (*9A)": 1}}	\N
6511420	6511090	c.1371C>T/c.2186C>T	{"DPYD": {"c.1371C>T": 1, "c.2186C>T": 1}}	\N
6511421	6511090	c.1577C>G/c.2656C>T	{"DPYD": {"c.1577C>G": 1, "c.2656C>T": 1}}	\N
6511422	6511090	c.498G>A/c.2977C>T	{"DPYD": {"c.498G>A": 1, "c.2977C>T": 1}}	\N
6511423	6511090	c.85T>C (*9A)/c.1990G>T	{"DPYD": {"c.1990G>T": 1, "c.85T>C (*9A)": 1}}	\N
6511424	6511090	c.1349C>T/c.2978T>G	{"DPYD": {"c.1349C>T": 1, "c.2978T>G": 1}}	\N
6511425	6511090	c.1371C>T/c.1601G>A (*4)	{"DPYD": {"c.1371C>T": 1, "c.1601G>A (*4)": 1}}	\N
6511426	6511090	c.1990G>T/c.2623A>C	{"DPYD": {"c.1990G>T": 1, "c.2623A>C": 1}}	\N
6511427	6511090	c.2657G>A (*9B)/c.3061G>C	{"DPYD": {"c.3061G>C": 1, "c.2657G>A (*9B)": 1}}	\N
6511428	6511090	c.313G>A/c.1682G>T	{"DPYD": {"c.313G>A": 1, "c.1682G>T": 1}}	\N
6511429	6511090	c.1990G>T/Reference	{"DPYD": {"Reference": 1, "c.1990G>T": 1}}	\N
6511430	6511090	c.343A>G/c.2657G>A (*9B)	{"DPYD": {"c.343A>G": 1, "c.2657G>A (*9B)": 1}}	\N
6511431	6511090	c.1260T>A/c.1278G>T	{"DPYD": {"c.1260T>A": 1, "c.1278G>T": 1}}	\N
6511432	6511090	c.1278G>T/c.1278G>T	{"DPYD": {"c.1278G>T": 2}}	\N
6511433	6511090	c.62G>A/c.498G>A	{"DPYD": {"c.62G>A": 1, "c.498G>A": 1}}	\N
6511434	6511090	c.1682G>T/c.2656C>T	{"DPYD": {"c.1682G>T": 1, "c.2656C>T": 1}}	\N
6511435	6511090	c.1294G>A/c.1577C>G	{"DPYD": {"c.1294G>A": 1, "c.1577C>G": 1}}	\N
6511436	6511090	c.1260T>A/c.2657G>A (*9B)	{"DPYD": {"c.1260T>A": 1, "c.2657G>A (*9B)": 1}}	\N
6511437	6511090	c.2582A>G/c.2978T>G	{"DPYD": {"c.2582A>G": 1, "c.2978T>G": 1}}	\N
6511438	6511090	c.1682G>T/c.1796T>C	{"DPYD": {"c.1682G>T": 1, "c.1796T>C": 1}}	\N
6511439	6511090	c.1796T>C/c.1796T>C	{"DPYD": {"c.1796T>C": 2}}	\N
6511440	6511090	c.2186C>T/c.3049G>A	{"DPYD": {"c.2186C>T": 1, "c.3049G>A": 1}}	\N
6511441	6511090	c.934C>T/c.2657G>A (*9B)	{"DPYD": {"c.934C>T": 1, "c.2657G>A (*9B)": 1}}	\N
6511442	6511090	c.2921A>T/c.2977C>T	{"DPYD": {"c.2921A>T": 1, "c.2977C>T": 1}}	\N
6511443	6511090	c.1615G>A/c.1682G>T	{"DPYD": {"c.1615G>A": 1, "c.1682G>T": 1}}	\N
6511444	6511090	c.62G>A/c.2656C>T	{"DPYD": {"c.62G>A": 1, "c.2656C>T": 1}}	\N
6511445	6511090	c.1371C>T/c.1519G>A	{"DPYD": {"c.1371C>T": 1, "c.1519G>A": 1}}	\N
6511446	6511090	c.451A>G/c.2921A>T	{"DPYD": {"c.451A>G": 1, "c.2921A>T": 1}}	\N
6511447	6511090	c.1218G>A/c.1278G>T	{"DPYD": {"c.1218G>A": 1, "c.1278G>T": 1}}	\N
6511448	6511090	c.85T>C (*9A)/c.1371C>T	{"DPYD": {"c.1371C>T": 1, "c.85T>C (*9A)": 1}}	\N
6511449	6511090	c.1403C>A/c.3049G>A	{"DPYD": {"c.1403C>A": 1, "c.3049G>A": 1}}	\N
6511450	6511090	c.451A>G/c.1896T>C	{"DPYD": {"c.451A>G": 1, "c.1896T>C": 1}}	\N
6511451	6511090	c.2195T>G/c.2582A>G	{"DPYD": {"c.2195T>G": 1, "c.2582A>G": 1}}	\N
6511452	6511090	c.451A>G/c.1294G>A	{"DPYD": {"c.451A>G": 1, "c.1294G>A": 1}}	\N
6511453	6511090	c.525G>A/c.1358C>G	{"DPYD": {"c.525G>A": 1, "c.1358C>G": 1}}	\N
6511454	6511090	c.1358C>G/c.2161G>A	{"DPYD": {"c.1358C>G": 1, "c.2161G>A": 1}}	\N
6511455	6511090	c.934C>T/c.2194G>A (*6)	{"DPYD": {"c.934C>T": 1, "c.2194G>A (*6)": 1}}	\N
6511456	6511090	c.1260T>A/c.2194G>A (*6)	{"DPYD": {"c.1260T>A": 1, "c.2194G>A (*6)": 1}}	\N
6511457	6511090	c.2195T>G/Reference	{"DPYD": {"Reference": 1, "c.2195T>G": 1}}	\N
6511458	6511090	c.967G>A/c.1180C>T	{"DPYD": {"c.967G>A": 1, "c.1180C>T": 1}}	\N
6511459	6511090	c.62G>A/c.1796T>C	{"DPYD": {"c.62G>A": 1, "c.1796T>C": 1}}	\N
6511460	6511090	c.46C>G/c.1108A>G	{"DPYD": {"c.46C>G": 1, "c.1108A>G": 1}}	\N
6511461	6511090	c.1627A>G (*5)/c.2582A>G	{"DPYD": {"c.2582A>G": 1, "c.1627A>G (*5)": 1}}	\N
6511462	6511090	c.2336C>A/c.2915A>G	{"DPYD": {"c.2336C>A": 1, "c.2915A>G": 1}}	\N
6511463	6511090	c.1181G>T/c.1403C>A	{"DPYD": {"c.1181G>T": 1, "c.1403C>A": 1}}	\N
6511464	6511090	c.313G>A/c.1260T>A	{"DPYD": {"c.313G>A": 1, "c.1260T>A": 1}}	\N
6511465	6511090	c.1543G>A/c.1682G>T	{"DPYD": {"c.1543G>A": 1, "c.1682G>T": 1}}	\N
6511466	6511090	c.1218G>A/c.2194G>A (*6)	{"DPYD": {"c.1218G>A": 1, "c.2194G>A (*6)": 1}}	\N
6511467	6511090	c.2336C>A/c.2623A>C	{"DPYD": {"c.2336C>A": 1, "c.2623A>C": 1}}	\N
6511468	6511090	c.525G>A/c.2336C>A	{"DPYD": {"c.525G>A": 1, "c.2336C>A": 1}}	\N
6511469	6511090	c.496A>G/Reference	{"DPYD": {"c.496A>G": 1, "Reference": 1}}	\N
6511470	6511090	c.929T>C/c.2336C>A	{"DPYD": {"c.929T>C": 1, "c.2336C>A": 1}}	\N
6511471	6511090	c.1003G>T (*11)/c.1278G>T	{"DPYD": {"c.1278G>T": 1, "c.1003G>T (*11)": 1}}	\N
6511472	6511090	c.1601G>A (*4)/c.1627A>G (*5)	{"DPYD": {"c.1601G>A (*4)": 1, "c.1627A>G (*5)": 1}}	\N
6511473	6511090	c.1371C>T/Reference	{"DPYD": {"Reference": 1, "c.1371C>T": 1}}	\N
6511474	6511090	c.343A>G/c.1543G>A	{"DPYD": {"c.343A>G": 1, "c.1543G>A": 1}}	\N
6511475	6511090	c.1601G>A (*4)/c.1615G>A	{"DPYD": {"c.1615G>A": 1, "c.1601G>A (*4)": 1}}	\N
6511476	6511090	c.498G>A/c.3061G>C	{"DPYD": {"c.498G>A": 1, "c.3061G>C": 1}}	\N
6511477	6511090	c.967G>A/c.2194G>A (*6)	{"DPYD": {"c.967G>A": 1, "c.2194G>A (*6)": 1}}	\N
6511478	6511090	c.929T>C/c.1682G>T	{"DPYD": {"c.929T>C": 1, "c.1682G>T": 1}}	\N
6511479	6511090	c.1349C>T/c.1906A>C	{"DPYD": {"c.1349C>T": 1, "c.1906A>C": 1}}	\N
6511480	6511090	c.929T>C/c.1358C>G	{"DPYD": {"c.929T>C": 1, "c.1358C>G": 1}}	\N
6511481	6511090	c.2977C>T/c.3067C>A	{"DPYD": {"c.2977C>T": 1, "c.3067C>A": 1}}	\N
6511482	6511090	c.498G>A/c.525G>A	{"DPYD": {"c.498G>A": 1, "c.525G>A": 1}}	\N
6511483	6511090	c.1358C>G/c.2186C>T	{"DPYD": {"c.1358C>G": 1, "c.2186C>T": 1}}	\N
6511484	6511090	c.343A>G/c.1896T>C	{"DPYD": {"c.343A>G": 1, "c.1896T>C": 1}}	\N
6511485	6511090	c.2656C>T/c.2921A>T	{"DPYD": {"c.2656C>T": 1, "c.2921A>T": 1}}	\N
6511486	6511090	c.775A>G/c.2977C>T	{"DPYD": {"c.775A>G": 1, "c.2977C>T": 1}}	\N
6511487	6511090	c.1180C>T/c.1358C>G	{"DPYD": {"c.1180C>T": 1, "c.1358C>G": 1}}	\N
6511488	6511090	c.775A>G/c.2656C>T	{"DPYD": {"c.775A>G": 1, "c.2656C>T": 1}}	\N
6511489	6511090	c.451A>G/c.2657G>A (*9B)	{"DPYD": {"c.451A>G": 1, "c.2657G>A (*9B)": 1}}	\N
6511490	6511090	c.2161G>A/c.2977C>T	{"DPYD": {"c.2161G>A": 1, "c.2977C>T": 1}}	\N
6511491	6511090	c.451A>G/c.2195T>G	{"DPYD": {"c.451A>G": 1, "c.2195T>G": 1}}	\N
6511492	6511090	c.525G>A/c.2482G>A	{"DPYD": {"c.525G>A": 1, "c.2482G>A": 1}}	\N
6511493	6511090	c.496A>G/c.1577C>G	{"DPYD": {"c.496A>G": 1, "c.1577C>G": 1}}	\N
6511494	6511090	c.343A>G/c.451A>G	{"DPYD": {"c.343A>G": 1, "c.451A>G": 1}}	\N
6511495	6511090	c.929T>C/c.1601G>A (*4)	{"DPYD": {"c.929T>C": 1, "c.1601G>A (*4)": 1}}	\N
6511496	6511090	c.1627A>G (*5)/c.2978T>G	{"DPYD": {"c.2978T>G": 1, "c.1627A>G (*5)": 1}}	\N
6511497	6511090	c.525G>A/c.2161G>A	{"DPYD": {"c.525G>A": 1, "c.2161G>A": 1}}	\N
6511498	6511090	c.525G>A/c.1371C>T	{"DPYD": {"c.525G>A": 1, "c.1371C>T": 1}}	\N
6511499	6511090	c.1601G>A (*4)/c.2195T>G	{"DPYD": {"c.2195T>G": 1, "c.1601G>A (*4)": 1}}	\N
6511500	6511090	c.85T>C (*9A)/c.3049G>A	{"DPYD": {"c.3049G>A": 1, "c.85T>C (*9A)": 1}}	\N
6511501	6511090	c.1601G>A (*4)/c.2657G>A (*9B)	{"DPYD": {"c.1601G>A (*4)": 1, "c.2657G>A (*9B)": 1}}	\N
6511502	6511090	c.2978T>G/c.3067C>A	{"DPYD": {"c.2978T>G": 1, "c.3067C>A": 1}}	\N
6511503	6511090	c.2623A>C/c.2657G>A (*9B)	{"DPYD": {"c.2623A>C": 1, "c.2657G>A (*9B)": 1}}	\N
6511504	6511090	c.1349C>T/c.2194G>A (*6)	{"DPYD": {"c.1349C>T": 1, "c.2194G>A (*6)": 1}}	\N
6511505	6511090	c.496A>G/c.1796T>C	{"DPYD": {"c.496A>G": 1, "c.1796T>C": 1}}	\N
6511506	6511090	c.496A>G/c.1682G>T	{"DPYD": {"c.496A>G": 1, "c.1682G>T": 1}}	\N
6511507	6511090	c.967G>A/c.1906A>C	{"DPYD": {"c.967G>A": 1, "c.1906A>C": 1}}	\N
6511508	6511090	c.1371C>T/c.3067C>A	{"DPYD": {"c.1371C>T": 1, "c.3067C>A": 1}}	\N
6511509	6511090	c.498G>A/Reference	{"DPYD": {"c.498G>A": 1, "Reference": 1}}	\N
6511510	6511090	c.1003G>T (*11)/c.2186C>T	{"DPYD": {"c.2186C>T": 1, "c.1003G>T (*11)": 1}}	\N
6511511	6511090	c.85T>C (*9A)/c.2194G>A (*6)	{"DPYD": {"c.85T>C (*9A)": 1, "c.2194G>A (*6)": 1}}	\N
6511512	6511090	c.1181G>T/c.1896T>C	{"DPYD": {"c.1181G>T": 1, "c.1896T>C": 1}}	\N
6511513	6511090	c.343A>G/c.934C>T	{"DPYD": {"c.343A>G": 1, "c.934C>T": 1}}	\N
6511514	6511090	c.775A>G/c.1218G>A	{"DPYD": {"c.775A>G": 1, "c.1218G>A": 1}}	\N
6511515	6511090	c.1278G>T/c.2921A>T	{"DPYD": {"c.1278G>T": 1, "c.2921A>T": 1}}	\N
6511516	6511090	c.343A>G/c.2623A>C	{"DPYD": {"c.343A>G": 1, "c.2623A>C": 1}}	\N
6511517	6511090	c.498G>A/c.934C>T	{"DPYD": {"c.498G>A": 1, "c.934C>T": 1}}	\N
6511518	6511090	c.46C>G/c.46C>G	{"DPYD": {"c.46C>G": 2}}	\N
6511519	6511090	c.343A>G/c.1905C>G	{"DPYD": {"c.343A>G": 1, "c.1905C>G": 1}}	\N
6511520	6511090	c.1294G>A/c.2915A>G	{"DPYD": {"c.1294G>A": 1, "c.2915A>G": 1}}	\N
6511521	6511090	c.496A>G/c.1601G>A (*4)	{"DPYD": {"c.496A>G": 1, "c.1601G>A (*4)": 1}}	\N
6511522	6511090	c.451A>G/c.2582A>G	{"DPYD": {"c.451A>G": 1, "c.2582A>G": 1}}	\N
6511523	6511090	c.3061G>C/c.3067C>A	{"DPYD": {"c.3061G>C": 1, "c.3067C>A": 1}}	\N
6511524	6511090	c.85T>C (*9A)/c.775A>G	{"DPYD": {"c.775A>G": 1, "c.85T>C (*9A)": 1}}	\N
6511525	6511090	c.1896T>C/Reference	{"DPYD": {"Reference": 1, "c.1896T>C": 1}}	\N
6511526	6511090	c.1181G>T/c.1905C>G	{"DPYD": {"c.1181G>T": 1, "c.1905C>G": 1}}	\N
6511527	6511090	c.62G>A/c.2915A>G	{"DPYD": {"c.62G>A": 1, "c.2915A>G": 1}}	\N
6511528	6511090	c.1181G>T/c.2623A>C	{"DPYD": {"c.1181G>T": 1, "c.2623A>C": 1}}	\N
6511529	6511090	c.496A>G/c.1371C>T	{"DPYD": {"c.496A>G": 1, "c.1371C>T": 1}}	\N
6511530	6511090	c.498G>A/c.1896T>C	{"DPYD": {"c.498G>A": 1, "c.1896T>C": 1}}	\N
6511531	6511090	c.1905C>G/c.2161G>A	{"DPYD": {"c.1905C>G": 1, "c.2161G>A": 1}}	\N
6511532	6511090	c.2656C>T/c.3049G>A	{"DPYD": {"c.2656C>T": 1, "c.3049G>A": 1}}	\N
6511533	6511090	c.313G>A/c.498G>A	{"DPYD": {"c.313G>A": 1, "c.498G>A": 1}}	\N
6511534	6511090	c.1627A>G (*5)/c.1905C>G	{"DPYD": {"c.1905C>G": 1, "c.1627A>G (*5)": 1}}	\N
6511535	6511090	c.967G>A/c.1403C>A	{"DPYD": {"c.967G>A": 1, "c.1403C>A": 1}}	\N
6511536	6511090	c.1003G>T (*11)/c.2915A>G	{"DPYD": {"c.2915A>G": 1, "c.1003G>T (*11)": 1}}	\N
6511537	6511090	c.929T>C/c.1896T>C	{"DPYD": {"c.929T>C": 1, "c.1896T>C": 1}}	\N
6511538	6511090	c.1180C>T/c.1543G>A	{"DPYD": {"c.1180C>T": 1, "c.1543G>A": 1}}	\N
6511539	6511090	c.1371C>T/c.2977C>T	{"DPYD": {"c.1371C>T": 1, "c.2977C>T": 1}}	\N
6511540	6511090	c.525G>A/c.934C>T	{"DPYD": {"c.525G>A": 1, "c.934C>T": 1}}	\N
6511541	6511090	c.1358C>G/c.2336C>A	{"DPYD": {"c.1358C>G": 1, "c.2336C>A": 1}}	\N
6511542	6511090	c.62G>A/c.1108A>G	{"DPYD": {"c.62G>A": 1, "c.1108A>G": 1}}	\N
6511543	6511090	c.1896T>C/c.2482G>A	{"DPYD": {"c.1896T>C": 1, "c.2482G>A": 1}}	\N
6511544	6511090	c.1896T>C/c.2161G>A	{"DPYD": {"c.1896T>C": 1, "c.2161G>A": 1}}	\N
6511545	6511090	c.62G>A/c.2186C>T	{"DPYD": {"c.62G>A": 1, "c.2186C>T": 1}}	\N
6511546	6511090	c.1349C>T/c.1519G>A	{"DPYD": {"c.1349C>T": 1, "c.1519G>A": 1}}	\N
6511547	6511090	c.343A>G/c.525G>A	{"DPYD": {"c.343A>G": 1, "c.525G>A": 1}}	\N
6511548	6511090	c.1519G>A/c.2915A>G	{"DPYD": {"c.1519G>A": 1, "c.2915A>G": 1}}	\N
6511549	6511090	c.1358C>G/c.1627A>G (*5)	{"DPYD": {"c.1358C>G": 1, "c.1627A>G (*5)": 1}}	\N
6511550	6511090	c.343A>G/c.3061G>C	{"DPYD": {"c.343A>G": 1, "c.3061G>C": 1}}	\N
6511551	6511090	c.1278G>T/c.3049G>A	{"DPYD": {"c.1278G>T": 1, "c.3049G>A": 1}}	\N
6511552	6511090	c.1682G>T/c.2161G>A	{"DPYD": {"c.1682G>T": 1, "c.2161G>A": 1}}	\N
6511553	6511090	c.62G>A/c.1260T>A	{"DPYD": {"c.62G>A": 1, "c.1260T>A": 1}}	\N
6511554	6511090	c.1403C>A/c.1615G>A	{"DPYD": {"c.1403C>A": 1, "c.1615G>A": 1}}	\N
6511555	6511090	c.498G>A/c.1543G>A	{"DPYD": {"c.498G>A": 1, "c.1543G>A": 1}}	\N
6511556	6511090	c.1181G>T/c.3061G>C	{"DPYD": {"c.1181G>T": 1, "c.3061G>C": 1}}	\N
6511557	6511090	c.929T>C/c.2623A>C	{"DPYD": {"c.929T>C": 1, "c.2623A>C": 1}}	\N
6511558	6511090	c.1180C>T/c.1615G>A	{"DPYD": {"c.1180C>T": 1, "c.1615G>A": 1}}	\N
6511559	6511090	c.1180C>T/c.1371C>T	{"DPYD": {"c.1180C>T": 1, "c.1371C>T": 1}}	\N
6511560	6511090	c.1627A>G (*5)/c.2623A>C	{"DPYD": {"c.2623A>C": 1, "c.1627A>G (*5)": 1}}	\N
6511561	6511090	c.1906A>C/c.2921A>T	{"DPYD": {"c.1906A>C": 1, "c.2921A>T": 1}}	\N
6511562	6511090	c.2915A>G/c.2915A>G	{"DPYD": {"c.2915A>G": 2}}	\N
6511563	6511090	c.1403C>A/c.1796T>C	{"DPYD": {"c.1403C>A": 1, "c.1796T>C": 1}}	\N
6511564	6511090	c.1278G>T/c.1403C>A	{"DPYD": {"c.1278G>T": 1, "c.1403C>A": 1}}	\N
6511565	6511090	c.1003G>T (*11)/c.1627A>G (*5)	{"DPYD": {"c.1627A>G (*5)": 1, "c.1003G>T (*11)": 1}}	\N
6511566	6511090	c.1294G>A/c.1627A>G (*5)	{"DPYD": {"c.1294G>A": 1, "c.1627A>G (*5)": 1}}	\N
6511567	6511090	c.525G>A/c.525G>A	{"DPYD": {"c.525G>A": 2}}	\N
6511568	6511090	c.2336C>A/c.2336C>A	{"DPYD": {"c.2336C>A": 2}}	\N
6511569	6511090	c.967G>A/c.1990G>T	{"DPYD": {"c.967G>A": 1, "c.1990G>T": 1}}	\N
6511570	6511090	c.929T>C/c.1577C>G	{"DPYD": {"c.929T>C": 1, "c.1577C>G": 1}}	\N
6511571	6511090	c.2303C>A/c.2582A>G	{"DPYD": {"c.2303C>A": 1, "c.2582A>G": 1}}	\N
6511572	6511090	c.1577C>G/c.2977C>T	{"DPYD": {"c.1577C>G": 1, "c.2977C>T": 1}}	\N
6511573	6511090	c.85T>C (*9A)/c.1519G>A	{"DPYD": {"c.1519G>A": 1, "c.85T>C (*9A)": 1}}	\N
6511574	6511090	c.934C>T/c.1180C>T	{"DPYD": {"c.934C>T": 1, "c.1180C>T": 1}}	\N
6511575	6511090	c.1218G>A/c.2978T>G	{"DPYD": {"c.1218G>A": 1, "c.2978T>G": 1}}	\N
6511576	6511090	c.929T>C/c.3061G>C	{"DPYD": {"c.929T>C": 1, "c.3061G>C": 1}}	\N
6511577	6511090	c.496A>G/c.2623A>C	{"DPYD": {"c.496A>G": 1, "c.2623A>C": 1}}	\N
6511578	6511090	c.46C>G/c.929T>C	{"DPYD": {"c.46C>G": 1, "c.929T>C": 1}}	\N
6511579	6511090	c.934C>T/c.2978T>G	{"DPYD": {"c.934C>T": 1, "c.2978T>G": 1}}	\N
6511580	6511090	c.934C>T/Reference	{"DPYD": {"c.934C>T": 1, "Reference": 1}}	\N
6511581	6511090	c.1181G>T/c.2186C>T	{"DPYD": {"c.1181G>T": 1, "c.2186C>T": 1}}	\N
6511582	6511090	c.2194G>A (*6)/c.2921A>T	{"DPYD": {"c.2921A>T": 1, "c.2194G>A (*6)": 1}}	\N
6511583	6511090	c.1577C>G/c.1906A>C	{"DPYD": {"c.1577C>G": 1, "c.1906A>C": 1}}	\N
6511584	6511090	c.85T>C (*9A)/c.496A>G	{"DPYD": {"c.496A>G": 1, "c.85T>C (*9A)": 1}}	\N
6511585	6511090	c.1615G>A/c.2303C>A	{"DPYD": {"c.1615G>A": 1, "c.2303C>A": 1}}	\N
6511586	6511090	c.498G>A/c.1615G>A	{"DPYD": {"c.498G>A": 1, "c.1615G>A": 1}}	\N
6511587	6511090	c.46C>G/c.1180C>T	{"DPYD": {"c.46C>G": 1, "c.1180C>T": 1}}	\N
6511588	6511090	c.1180C>T/c.1181G>T	{"DPYD": {"c.1180C>T": 1, "c.1181G>T": 1}}	\N
6511589	6511090	c.1615G>A/c.1990G>T	{"DPYD": {"c.1615G>A": 1, "c.1990G>T": 1}}	\N
6511590	6511090	c.451A>G/c.498G>A	{"DPYD": {"c.451A>G": 1, "c.498G>A": 1}}	\N
6511591	6511090	c.967G>A/c.1108A>G	{"DPYD": {"c.967G>A": 1, "c.1108A>G": 1}}	\N
6511592	6511090	c.451A>G/c.1358C>G	{"DPYD": {"c.451A>G": 1, "c.1358C>G": 1}}	\N
6511593	6511090	c.1294G>A/c.1349C>T	{"DPYD": {"c.1294G>A": 1, "c.1349C>T": 1}}	\N
6511594	6511090	c.967G>A/c.1260T>A	{"DPYD": {"c.967G>A": 1, "c.1260T>A": 1}}	\N
6511595	6511090	c.498G>A/c.2336C>A	{"DPYD": {"c.498G>A": 1, "c.2336C>A": 1}}	\N
6511596	6511090	c.1371C>T/c.1906A>C	{"DPYD": {"c.1371C>T": 1, "c.1906A>C": 1}}	\N
6511597	6511090	c.451A>G/c.1577C>G	{"DPYD": {"c.451A>G": 1, "c.1577C>G": 1}}	\N
6511598	6511090	c.929T>C/c.1905C>G	{"DPYD": {"c.929T>C": 1, "c.1905C>G": 1}}	\N
6511599	6511090	c.1260T>A/c.1615G>A	{"DPYD": {"c.1260T>A": 1, "c.1615G>A": 1}}	\N
6511600	6511090	c.1615G>A/c.3067C>A	{"DPYD": {"c.1615G>A": 1, "c.3067C>A": 1}}	\N
6511601	6511090	c.451A>G/c.1601G>A (*4)	{"DPYD": {"c.451A>G": 1, "c.1601G>A (*4)": 1}}	\N
6511602	6511090	c.451A>G/c.1682G>T	{"DPYD": {"c.451A>G": 1, "c.1682G>T": 1}}	\N
6511603	6511090	c.62G>A/c.2978T>G	{"DPYD": {"c.62G>A": 1, "c.2978T>G": 1}}	\N
6511604	6511090	c.929T>C/c.2582A>G	{"DPYD": {"c.929T>C": 1, "c.2582A>G": 1}}	\N
6511605	6511090	c.498G>A/c.1278G>T	{"DPYD": {"c.498G>A": 1, "c.1278G>T": 1}}	\N
6511606	6511090	c.1278G>T/c.1294G>A	{"DPYD": {"c.1278G>T": 1, "c.1294G>A": 1}}	\N
6511607	6511090	c.2915A>G/c.2978T>G	{"DPYD": {"c.2915A>G": 1, "c.2978T>G": 1}}	\N
6511608	6511090	c.967G>A/c.1349C>T	{"DPYD": {"c.967G>A": 1, "c.1349C>T": 1}}	\N
6511609	6511090	c.1519G>A/c.2186C>T	{"DPYD": {"c.1519G>A": 1, "c.2186C>T": 1}}	\N
6511610	6511090	c.1294G>A/c.2978T>G	{"DPYD": {"c.1294G>A": 1, "c.2978T>G": 1}}	\N
6511611	6511090	c.496A>G/c.2657G>A (*9B)	{"DPYD": {"c.496A>G": 1, "c.2657G>A (*9B)": 1}}	\N
6511612	6511090	c.1627A>G (*5)/c.2915A>G	{"DPYD": {"c.2915A>G": 1, "c.1627A>G (*5)": 1}}	\N
6511613	6511090	c.496A>G/c.2195T>G	{"DPYD": {"c.496A>G": 1, "c.2195T>G": 1}}	\N
6511614	6511090	c.343A>G/c.2482G>A	{"DPYD": {"c.343A>G": 1, "c.2482G>A": 1}}	\N
6511615	6511090	c.967G>A/c.1519G>A	{"DPYD": {"c.967G>A": 1, "c.1519G>A": 1}}	\N
6500449	6499734	*1/*84	{"CYP2D6": {"*1": 1, "*84": 1}}	{"Latino": null, "American": 0.0, "European": 0.0, "Oceanian": null, "East Asian": 0.0, "Near Eastern": null, "Central/South Asian": 0.0, "Sub-Saharan African": 0.00031353152, "African American/Afro-Caribbean": 0.0012669443}
6500450	6499734	*1/*87	{"CYP2D6": {"*1": 1, "*87": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
6500451	6499734	*1/*86	{"CYP2D6": {"*1": 1, "*86": 1}}	{"Latino": null, "American": 0.0, "European": 0.0, "Oceanian": null, "East Asian": 0.00009844224, "Near Eastern": null, "Central/South Asian": 0.012543308, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": 0.0}
6500452	6499734	*1/*89	{"CYP2D6": {"*1": 1, "*89": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
6500453	6499734	*1/*88	{"CYP2D6": {"*1": 1, "*88": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
6500454	6499734	*28x2/*45	{"CYP2D6": {"*45": 1, "*28x2": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
6500455	6499734	*28x2/*46	{"CYP2D6": {"*46": 1, "*28x2": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
6500456	6499734	*28x2/*48	{"CYP2D6": {"*48": 1, "*28x2": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
6500457	6499734	*61/*68+*2	{"CYP2D6": {"*61": 1, "*68+*2": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
6500458	6499734	*28x2/*53	{"CYP2D6": {"*53": 1, "*28x2": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
6500459	6499734	*1/*90	{"CYP2D6": {"*1": 1, "*90": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
6511616	6511090	c.85T>C (*9A)/c.2915A>G	{"DPYD": {"c.2915A>G": 1, "c.85T>C (*9A)": 1}}	\N
6511617	6511090	c.451A>G/c.1796T>C	{"DPYD": {"c.451A>G": 1, "c.1796T>C": 1}}	\N
6511618	6511090	c.1260T>A/c.1796T>C	{"DPYD": {"c.1260T>A": 1, "c.1796T>C": 1}}	\N
6511619	6511090	c.1519G>A/c.1627A>G (*5)	{"DPYD": {"c.1519G>A": 1, "c.1627A>G (*5)": 1}}	\N
6511620	6511090	c.1543G>A/c.1906A>C	{"DPYD": {"c.1543G>A": 1, "c.1906A>C": 1}}	\N
6511621	6511090	c.775A>G/c.1990G>T	{"DPYD": {"c.775A>G": 1, "c.1990G>T": 1}}	\N
6511622	6511090	c.1358C>G/c.1896T>C	{"DPYD": {"c.1358C>G": 1, "c.1896T>C": 1}}	\N
6511623	6511090	c.1218G>A/c.1796T>C	{"DPYD": {"c.1218G>A": 1, "c.1796T>C": 1}}	\N
6511624	6511090	c.1181G>T/c.2978T>G	{"DPYD": {"c.1181G>T": 1, "c.2978T>G": 1}}	\N
6511625	6511090	c.62G>A/c.2336C>A	{"DPYD": {"c.62G>A": 1, "c.2336C>A": 1}}	\N
6511626	6511090	c.62G>A/c.85T>C (*9A)	{"DPYD": {"c.62G>A": 1, "c.85T>C (*9A)": 1}}	\N
6511627	6511090	c.1003G>T (*11)/c.1260T>A	{"DPYD": {"c.1260T>A": 1, "c.1003G>T (*11)": 1}}	\N
6511628	6511090	c.775A>G/c.1906A>C	{"DPYD": {"c.775A>G": 1, "c.1906A>C": 1}}	\N
6511629	6511090	c.1180C>T/Reference	{"DPYD": {"Reference": 1, "c.1180C>T": 1}}	\N
6511630	6511090	c.313G>A/c.2194G>A (*6)	{"DPYD": {"c.313G>A": 1, "c.2194G>A (*6)": 1}}	\N
6511631	6511090	c.2195T>G/c.2336C>A	{"DPYD": {"c.2195T>G": 1, "c.2336C>A": 1}}	\N
6511632	6511090	c.929T>C/c.1796T>C	{"DPYD": {"c.929T>C": 1, "c.1796T>C": 1}}	\N
6511633	6511090	c.1181G>T/c.2336C>A	{"DPYD": {"c.1181G>T": 1, "c.2336C>A": 1}}	\N
6511634	6511090	c.46C>G/c.1278G>T	{"DPYD": {"c.46C>G": 1, "c.1278G>T": 1}}	\N
6511635	6511090	c.1349C>T/c.2656C>T	{"DPYD": {"c.1349C>T": 1, "c.2656C>T": 1}}	\N
6511636	6511090	c.1108A>G/c.1543G>A	{"DPYD": {"c.1108A>G": 1, "c.1543G>A": 1}}	\N
6511637	6511090	c.1371C>T/c.2303C>A	{"DPYD": {"c.1371C>T": 1, "c.2303C>A": 1}}	\N
6511638	6511090	c.525G>A/c.1615G>A	{"DPYD": {"c.525G>A": 1, "c.1615G>A": 1}}	\N
6511639	6511090	c.1577C>G/c.1990G>T	{"DPYD": {"c.1577C>G": 1, "c.1990G>T": 1}}	\N
6511640	6511090	c.1543G>A/c.1990G>T	{"DPYD": {"c.1543G>A": 1, "c.1990G>T": 1}}	\N
6511641	6511090	c.3049G>A/Reference	{"DPYD": {"Reference": 1, "c.3049G>A": 1}}	\N
6511642	6511090	c.85T>C (*9A)/c.1627A>G (*5)	{"DPYD": {"c.85T>C (*9A)": 1, "c.1627A>G (*5)": 1}}	\N
6511643	6511090	c.2582A>G/c.2915A>G	{"DPYD": {"c.2582A>G": 1, "c.2915A>G": 1}}	\N
6511644	6511090	c.62G>A/c.1896T>C	{"DPYD": {"c.62G>A": 1, "c.1896T>C": 1}}	\N
6511645	6511090	c.775A>G/c.967G>A	{"DPYD": {"c.775A>G": 1, "c.967G>A": 1}}	\N
6511646	6511090	c.1180C>T/c.2482G>A	{"DPYD": {"c.1180C>T": 1, "c.2482G>A": 1}}	\N
6511647	6511090	c.1371C>T/c.1990G>T	{"DPYD": {"c.1371C>T": 1, "c.1990G>T": 1}}	\N
6511648	6511090	c.1519G>A/c.1519G>A	{"DPYD": {"c.1519G>A": 2}}	\N
6511649	6511090	c.1990G>T/c.1990G>T	{"DPYD": {"c.1990G>T": 2}}	\N
6511650	6511090	c.1294G>A/c.2186C>T	{"DPYD": {"c.1294G>A": 1, "c.2186C>T": 1}}	\N
6511651	6511090	c.85T>C (*9A)/c.1180C>T	{"DPYD": {"c.1180C>T": 1, "c.85T>C (*9A)": 1}}	\N
6511652	6511090	c.1615G>A/c.1906A>C	{"DPYD": {"c.1615G>A": 1, "c.1906A>C": 1}}	\N
6511653	6511090	c.525G>A/c.1181G>T	{"DPYD": {"c.525G>A": 1, "c.1181G>T": 1}}	\N
6511654	6511090	c.1577C>G/c.2194G>A (*6)	{"DPYD": {"c.1577C>G": 1, "c.2194G>A (*6)": 1}}	\N
6511655	6511090	c.313G>A/c.496A>G	{"DPYD": {"c.313G>A": 1, "c.496A>G": 1}}	\N
6511656	6511090	c.451A>G/c.2623A>C	{"DPYD": {"c.451A>G": 1, "c.2623A>C": 1}}	\N
6511657	6511090	c.1543G>A/c.3067C>A	{"DPYD": {"c.1543G>A": 1, "c.3067C>A": 1}}	\N
6511658	6511090	c.525G>A/Reference	{"DPYD": {"c.525G>A": 1, "Reference": 1}}	\N
6511659	6511090	c.496A>G/c.1003G>T (*11)	{"DPYD": {"c.496A>G": 1, "c.1003G>T (*11)": 1}}	\N
6511660	6511090	c.85T>C (*9A)/c.1403C>A	{"DPYD": {"c.1403C>A": 1, "c.85T>C (*9A)": 1}}	\N
6511661	6511090	c.496A>G/c.1358C>G	{"DPYD": {"c.496A>G": 1, "c.1358C>G": 1}}	\N
6511662	6511090	c.62G>A/c.1349C>T	{"DPYD": {"c.62G>A": 1, "c.1349C>T": 1}}	\N
6511663	6511090	c.1990G>T/c.3067C>A	{"DPYD": {"c.1990G>T": 1, "c.3067C>A": 1}}	\N
6511664	6511090	c.2623A>C/Reference	{"DPYD": {"Reference": 1, "c.2623A>C": 1}}	\N
6511665	6511090	c.1358C>G/c.3061G>C	{"DPYD": {"c.1358C>G": 1, "c.3061G>C": 1}}	\N
6511666	6511090	c.2336C>A/c.3061G>C	{"DPYD": {"c.2336C>A": 1, "c.3061G>C": 1}}	\N
6511667	6511090	c.1181G>T/c.2657G>A (*9B)	{"DPYD": {"c.1181G>T": 1, "c.2657G>A (*9B)": 1}}	\N
6511668	6511090	c.934C>T/c.1108A>G	{"DPYD": {"c.934C>T": 1, "c.1108A>G": 1}}	\N
6511669	6511090	c.343A>G/c.1627A>G (*5)	{"DPYD": {"c.343A>G": 1, "c.1627A>G (*5)": 1}}	\N
6511670	6511090	c.1906A>C/c.3067C>A	{"DPYD": {"c.1906A>C": 1, "c.3067C>A": 1}}	\N
6511671	6511090	c.1990G>T/c.2303C>A	{"DPYD": {"c.1990G>T": 1, "c.2303C>A": 1}}	\N
6511672	6511090	c.1403C>A/c.2161G>A	{"DPYD": {"c.1403C>A": 1, "c.2161G>A": 1}}	\N
6511673	6511090	c.46C>G/c.1003G>T (*11)	{"DPYD": {"c.46C>G": 1, "c.1003G>T (*11)": 1}}	\N
6511674	6511090	c.967G>A/c.3049G>A	{"DPYD": {"c.967G>A": 1, "c.3049G>A": 1}}	\N
6511675	6511090	c.343A>G/c.1601G>A (*4)	{"DPYD": {"c.343A>G": 1, "c.1601G>A (*4)": 1}}	\N
6511676	6511090	c.46C>G/c.1358C>G	{"DPYD": {"c.46C>G": 1, "c.1358C>G": 1}}	\N
6511677	6511090	c.1218G>A/Reference	{"DPYD": {"Reference": 1, "c.1218G>A": 1}}	\N
6511678	6511090	c.1108A>G/Reference	{"DPYD": {"Reference": 1, "c.1108A>G": 1}}	\N
6511679	6511090	c.1349C>T/c.1627A>G (*5)	{"DPYD": {"c.1349C>T": 1, "c.1627A>G (*5)": 1}}	\N
6511680	6511090	c.343A>G/c.1682G>T	{"DPYD": {"c.343A>G": 1, "c.1682G>T": 1}}	\N
6511681	6511090	c.2194G>A (*6)/c.2195T>G	{"DPYD": {"c.2195T>G": 1, "c.2194G>A (*6)": 1}}	\N
6511682	6511090	c.1543G>A/c.2303C>A	{"DPYD": {"c.1543G>A": 1, "c.2303C>A": 1}}	\N
6511683	6511090	c.2194G>A (*6)/c.2657G>A (*9B)	{"DPYD": {"c.2194G>A (*6)": 1, "c.2657G>A (*9B)": 1}}	\N
6511684	6511090	c.1260T>A/Reference	{"DPYD": {"Reference": 1, "c.1260T>A": 1}}	\N
6511685	6511090	c.525G>A/c.1543G>A	{"DPYD": {"c.525G>A": 1, "c.1543G>A": 1}}	\N
6511686	6511090	c.498G>A/c.2161G>A	{"DPYD": {"c.498G>A": 1, "c.2161G>A": 1}}	\N
6511687	6511090	c.1906A>C/c.2303C>A	{"DPYD": {"c.1906A>C": 1, "c.2303C>A": 1}}	\N
6511688	6511090	c.1403C>A/c.1577C>G	{"DPYD": {"c.1403C>A": 1, "c.1577C>G": 1}}	\N
6511689	6511090	c.496A>G/c.498G>A	{"DPYD": {"c.496A>G": 1, "c.498G>A": 1}}	\N
6511690	6511090	c.1294G>A/c.3049G>A	{"DPYD": {"c.1294G>A": 1, "c.3049G>A": 1}}	\N
6511691	6511090	c.934C>T/c.1796T>C	{"DPYD": {"c.934C>T": 1, "c.1796T>C": 1}}	\N
6511692	6511090	c.2161G>A/c.2194G>A (*6)	{"DPYD": {"c.2161G>A": 1, "c.2194G>A (*6)": 1}}	\N
6511693	6511090	c.1294G>A/c.1601G>A (*4)	{"DPYD": {"c.1294G>A": 1, "c.1601G>A (*4)": 1}}	\N
6511694	6511090	c.1181G>T/c.2195T>G	{"DPYD": {"c.1181G>T": 1, "c.2195T>G": 1}}	\N
6511695	6511090	c.1615G>A/c.2656C>T	{"DPYD": {"c.1615G>A": 1, "c.2656C>T": 1}}	\N
6511696	6511090	c.62G>A/c.1601G>A (*4)	{"DPYD": {"c.62G>A": 1, "c.1601G>A (*4)": 1}}	\N
6511697	6511090	c.1627A>G (*5)/c.1796T>C	{"DPYD": {"c.1796T>C": 1, "c.1627A>G (*5)": 1}}	\N
6511698	6511090	c.1294G>A/c.1682G>T	{"DPYD": {"c.1294G>A": 1, "c.1682G>T": 1}}	\N
6511699	6511090	c.1990G>T/c.2336C>A	{"DPYD": {"c.1990G>T": 1, "c.2336C>A": 1}}	\N
6511700	6511090	c.1519G>A/c.2336C>A	{"DPYD": {"c.1519G>A": 1, "c.2336C>A": 1}}	\N
6511701	6511090	c.1543G>A/c.2336C>A	{"DPYD": {"c.1543G>A": 1, "c.2336C>A": 1}}	\N
6511702	6511090	c.2915A>G/c.3061G>C	{"DPYD": {"c.2915A>G": 1, "c.3061G>C": 1}}	\N
6511703	6511090	c.2336C>A/c.2482G>A	{"DPYD": {"c.2336C>A": 1, "c.2482G>A": 1}}	\N
6511704	6511090	c.967G>A/c.2186C>T	{"DPYD": {"c.967G>A": 1, "c.2186C>T": 1}}	\N
6511705	6511090	c.62G>A/c.1682G>T	{"DPYD": {"c.62G>A": 1, "c.1682G>T": 1}}	\N
6511706	6511090	c.1577C>G/c.2582A>G	{"DPYD": {"c.1577C>G": 1, "c.2582A>G": 1}}	\N
6511707	6511090	c.313G>A/c.2657G>A (*9B)	{"DPYD": {"c.313G>A": 1, "c.2657G>A (*9B)": 1}}	\N
6511708	6511090	c.1796T>C/c.2161G>A	{"DPYD": {"c.1796T>C": 1, "c.2161G>A": 1}}	\N
6511709	6511090	c.313G>A/c.1796T>C	{"DPYD": {"c.313G>A": 1, "c.1796T>C": 1}}	\N
6511710	6511090	c.1108A>G/c.2161G>A	{"DPYD": {"c.1108A>G": 1, "c.2161G>A": 1}}	\N
6511711	6511090	c.2303C>A/c.2623A>C	{"DPYD": {"c.2303C>A": 1, "c.2623A>C": 1}}	\N
6511712	6511090	c.451A>G/c.451A>G	{"DPYD": {"c.451A>G": 2}}	\N
6511713	6511090	c.1181G>T/c.2915A>G	{"DPYD": {"c.1181G>T": 1, "c.2915A>G": 1}}	\N
6511714	6511090	c.2303C>A/c.3049G>A	{"DPYD": {"c.2303C>A": 1, "c.3049G>A": 1}}	\N
6511715	6511090	c.313G>A/c.2195T>G	{"DPYD": {"c.313G>A": 1, "c.2195T>G": 1}}	\N
6511716	6511090	c.46C>G/c.1615G>A	{"DPYD": {"c.46C>G": 1, "c.1615G>A": 1}}	\N
6511717	6511090	c.934C>T/c.1577C>G	{"DPYD": {"c.934C>T": 1, "c.1577C>G": 1}}	\N
6511718	6511090	c.934C>T/c.1294G>A	{"DPYD": {"c.934C>T": 1, "c.1294G>A": 1}}	\N
6511719	6511090	c.1601G>A (*4)/c.2978T>G	{"DPYD": {"c.2978T>G": 1, "c.1601G>A (*4)": 1}}	\N
6511720	6511090	c.2582A>G/c.2623A>C	{"DPYD": {"c.2582A>G": 1, "c.2623A>C": 1}}	\N
6511721	6511090	c.46C>G/c.1371C>T	{"DPYD": {"c.46C>G": 1, "c.1371C>T": 1}}	\N
6511722	6511090	c.1003G>T (*11)/c.1543G>A	{"DPYD": {"c.1543G>A": 1, "c.1003G>T (*11)": 1}}	\N
6511723	6511090	c.1294G>A/c.2194G>A (*6)	{"DPYD": {"c.1294G>A": 1, "c.2194G>A (*6)": 1}}	\N
6511724	6511090	c.1627A>G (*5)/c.2657G>A (*9B)	{"DPYD": {"c.1627A>G (*5)": 1, "c.2657G>A (*9B)": 1}}	\N
6511725	6511090	c.1627A>G (*5)/c.2195T>G	{"DPYD": {"c.2195T>G": 1, "c.1627A>G (*5)": 1}}	\N
6511726	6511090	c.1003G>T (*11)/c.3061G>C	{"DPYD": {"c.3061G>C": 1, "c.1003G>T (*11)": 1}}	\N
6511727	6511090	c.46C>G/c.1181G>T	{"DPYD": {"c.46C>G": 1, "c.1181G>T": 1}}	\N
6511728	6511090	c.1358C>G/c.2482G>A	{"DPYD": {"c.1358C>G": 1, "c.2482G>A": 1}}	\N
6511729	6511090	c.775A>G/c.775A>G	{"DPYD": {"c.775A>G": 2}}	\N
6511730	6511090	c.46C>G/c.1294G>A	{"DPYD": {"c.46C>G": 1, "c.1294G>A": 1}}	\N
6511731	6511090	c.1181G>T/c.1260T>A	{"DPYD": {"c.1181G>T": 1, "c.1260T>A": 1}}	\N
6511732	6511090	c.62G>A/c.3061G>C	{"DPYD": {"c.62G>A": 1, "c.3061G>C": 1}}	\N
6511733	6511090	c.343A>G/c.1260T>A	{"DPYD": {"c.343A>G": 1, "c.1260T>A": 1}}	\N
6511734	6511090	c.1358C>G/c.1906A>C	{"DPYD": {"c.1358C>G": 1, "c.1906A>C": 1}}	\N
6511735	6511090	c.934C>T/c.1371C>T	{"DPYD": {"c.934C>T": 1, "c.1371C>T": 1}}	\N
6511736	6511090	c.46C>G/c.2161G>A	{"DPYD": {"c.46C>G": 1, "c.2161G>A": 1}}	\N
6511737	6511090	c.2482G>A/c.2921A>T	{"DPYD": {"c.2482G>A": 1, "c.2921A>T": 1}}	\N
6511738	6511090	c.775A>G/c.1682G>T	{"DPYD": {"c.775A>G": 1, "c.1682G>T": 1}}	\N
6511739	6511090	c.1905C>G/c.2921A>T	{"DPYD": {"c.1905C>G": 1, "c.2921A>T": 1}}	\N
6511740	6511090	c.1358C>G/c.1543G>A	{"DPYD": {"c.1358C>G": 1, "c.1543G>A": 1}}	\N
6511741	6511090	c.62G>A/c.2194G>A (*6)	{"DPYD": {"c.62G>A": 1, "c.2194G>A (*6)": 1}}	\N
6511742	6511090	c.1796T>C/Reference	{"DPYD": {"Reference": 1, "c.1796T>C": 1}}	\N
6511743	6511090	c.313G>A/c.1577C>G	{"DPYD": {"c.313G>A": 1, "c.1577C>G": 1}}	\N
6511744	6511090	c.1519G>A/c.2977C>T	{"DPYD": {"c.1519G>A": 1, "c.2977C>T": 1}}	\N
6511745	6511090	c.1519G>A/c.1896T>C	{"DPYD": {"c.1519G>A": 1, "c.1896T>C": 1}}	\N
6511746	6511090	c.1003G>T (*11)/c.1896T>C	{"DPYD": {"c.1896T>C": 1, "c.1003G>T (*11)": 1}}	\N
6511747	6511090	c.1294G>A/c.2623A>C	{"DPYD": {"c.1294G>A": 1, "c.2623A>C": 1}}	\N
6511748	6511090	c.525G>A/c.929T>C	{"DPYD": {"c.525G>A": 1, "c.929T>C": 1}}	\N
6511749	6511090	c.85T>C (*9A)/c.1108A>G	{"DPYD": {"c.1108A>G": 1, "c.85T>C (*9A)": 1}}	\N
6511750	6511090	c.2194G>A (*6)/c.3049G>A	{"DPYD": {"c.3049G>A": 1, "c.2194G>A (*6)": 1}}	\N
6511751	6511090	c.1181G>T/c.2582A>G	{"DPYD": {"c.1181G>T": 1, "c.2582A>G": 1}}	\N
6511752	6511090	c.929T>C/c.2978T>G	{"DPYD": {"c.929T>C": 1, "c.2978T>G": 1}}	\N
6511753	6511090	c.1577C>G/c.2915A>G	{"DPYD": {"c.1577C>G": 1, "c.2915A>G": 1}}	\N
6511754	6511090	c.775A>G/c.1601G>A (*4)	{"DPYD": {"c.775A>G": 1, "c.1601G>A (*4)": 1}}	\N
6511755	6511090	c.343A>G/c.2582A>G	{"DPYD": {"c.343A>G": 1, "c.2582A>G": 1}}	\N
6511756	6511090	c.1905C>G/Reference	{"DPYD": {"Reference": 1, "c.1905C>G": 1}}	\N
6511757	6511090	c.2623A>C/c.2921A>T	{"DPYD": {"c.2623A>C": 1, "c.2921A>T": 1}}	\N
6511758	6511090	c.1349C>T/c.2186C>T	{"DPYD": {"c.1349C>T": 1, "c.2186C>T": 1}}	\N
6511759	6511090	c.1358C>G/c.1990G>T	{"DPYD": {"c.1358C>G": 1, "c.1990G>T": 1}}	\N
6511760	6511090	c.313G>A/c.1349C>T	{"DPYD": {"c.313G>A": 1, "c.1349C>T": 1}}	\N
6511761	6511090	c.62G>A/c.1519G>A	{"DPYD": {"c.62G>A": 1, "c.1519G>A": 1}}	\N
6511762	6511090	c.496A>G/c.1180C>T	{"DPYD": {"c.496A>G": 1, "c.1180C>T": 1}}	\N
6511763	6511090	c.343A>G/c.967G>A	{"DPYD": {"c.343A>G": 1, "c.967G>A": 1}}	\N
6511764	6511090	c.313G>A/c.1180C>T	{"DPYD": {"c.313G>A": 1, "c.1180C>T": 1}}	\N
6511765	6511090	c.62G>A/c.451A>G	{"DPYD": {"c.62G>A": 1, "c.451A>G": 1}}	\N
6511766	6511090	c.343A>G/c.2186C>T	{"DPYD": {"c.343A>G": 1, "c.2186C>T": 1}}	\N
6511767	6511090	c.929T>C/c.2915A>G	{"DPYD": {"c.929T>C": 1, "c.2915A>G": 1}}	\N
6511768	6511090	c.496A>G/c.2978T>G	{"DPYD": {"c.496A>G": 1, "c.2978T>G": 1}}	\N
6511769	6511090	c.498G>A/c.2656C>T	{"DPYD": {"c.498G>A": 1, "c.2656C>T": 1}}	\N
6511770	6511090	c.1906A>C/c.2161G>A	{"DPYD": {"c.1906A>C": 1, "c.2161G>A": 1}}	\N
6511771	6511090	c.498G>A/c.1218G>A	{"DPYD": {"c.498G>A": 1, "c.1218G>A": 1}}	\N
6511772	6511090	c.1218G>A/c.1577C>G	{"DPYD": {"c.1218G>A": 1, "c.1577C>G": 1}}	\N
6511773	6511090	c.525G>A/c.2303C>A	{"DPYD": {"c.525G>A": 1, "c.2303C>A": 1}}	\N
6511774	6511090	c.1218G>A/c.1371C>T	{"DPYD": {"c.1218G>A": 1, "c.1371C>T": 1}}	\N
6511775	6511090	c.929T>C/c.1349C>T	{"DPYD": {"c.929T>C": 1, "c.1349C>T": 1}}	\N
6511776	6511090	c.2186C>T/c.2921A>T	{"DPYD": {"c.2186C>T": 1, "c.2921A>T": 1}}	\N
6511777	6511090	c.343A>G/c.2977C>T	{"DPYD": {"c.343A>G": 1, "c.2977C>T": 1}}	\N
6511778	6511090	c.313G>A/c.1403C>A	{"DPYD": {"c.313G>A": 1, "c.1403C>A": 1}}	\N
6511779	6511090	c.1577C>G/c.1601G>A (*4)	{"DPYD": {"c.1577C>G": 1, "c.1601G>A (*4)": 1}}	\N
6511780	6511090	c.775A>G/c.1896T>C	{"DPYD": {"c.775A>G": 1, "c.1896T>C": 1}}	\N
6511781	6511090	c.929T>C/c.2657G>A (*9B)	{"DPYD": {"c.929T>C": 1, "c.2657G>A (*9B)": 1}}	\N
6511782	6511090	c.46C>G/Reference	{"DPYD": {"c.46C>G": 1, "Reference": 1}}	\N
6511783	6511090	c.85T>C (*9A)/c.2195T>G	{"DPYD": {"c.2195T>G": 1, "c.85T>C (*9A)": 1}}	\N
6511784	6511090	c.85T>C (*9A)/c.2657G>A (*9B)	{"DPYD": {"c.85T>C (*9A)": 1, "c.2657G>A (*9B)": 1}}	\N
6511785	6511090	c.967G>A/c.2623A>C	{"DPYD": {"c.967G>A": 1, "c.2623A>C": 1}}	\N
6511786	6511090	c.313G>A/c.3049G>A	{"DPYD": {"c.313G>A": 1, "c.3049G>A": 1}}	\N
6511787	6511090	c.1180C>T/c.3067C>A	{"DPYD": {"c.1180C>T": 1, "c.3067C>A": 1}}	\N
6511788	6511090	c.929T>C/c.2195T>G	{"DPYD": {"c.929T>C": 1, "c.2195T>G": 1}}	\N
6511789	6511090	c.1519G>A/c.1906A>C	{"DPYD": {"c.1519G>A": 1, "c.1906A>C": 1}}	\N
6511790	6511090	c.967G>A/c.1905C>G	{"DPYD": {"c.967G>A": 1, "c.1905C>G": 1}}	\N
6511791	6511090	c.2921A>T/c.3049G>A	{"DPYD": {"c.2921A>T": 1, "c.3049G>A": 1}}	\N
6511792	6511090	c.1294G>A/c.2195T>G	{"DPYD": {"c.1294G>A": 1, "c.2195T>G": 1}}	\N
6511793	6511090	c.343A>G/c.2336C>A	{"DPYD": {"c.343A>G": 1, "c.2336C>A": 1}}	\N
6511794	6511090	c.1294G>A/c.2657G>A (*9B)	{"DPYD": {"c.1294G>A": 1, "c.2657G>A (*9B)": 1}}	\N
6511795	6511090	c.1108A>G/c.1278G>T	{"DPYD": {"c.1108A>G": 1, "c.1278G>T": 1}}	\N
6511796	6511090	c.1577C>G/c.3061G>C	{"DPYD": {"c.1577C>G": 1, "c.3061G>C": 1}}	\N
6511797	6511090	c.1180C>T/c.1278G>T	{"DPYD": {"c.1180C>T": 1, "c.1278G>T": 1}}	\N
6511798	6511090	c.2303C>A/c.2978T>G	{"DPYD": {"c.2303C>A": 1, "c.2978T>G": 1}}	\N
6511799	6511090	c.1627A>G (*5)/c.3049G>A	{"DPYD": {"c.3049G>A": 1, "c.1627A>G (*5)": 1}}	\N
6511800	6511090	c.775A>G/c.1260T>A	{"DPYD": {"c.775A>G": 1, "c.1260T>A": 1}}	\N
6511801	6511090	c.1278G>T/c.1371C>T	{"DPYD": {"c.1278G>T": 1, "c.1371C>T": 1}}	\N
6511802	6511090	c.525G>A/c.3067C>A	{"DPYD": {"c.525G>A": 1, "c.3067C>A": 1}}	\N
6511803	6511090	c.1403C>A/Reference	{"DPYD": {"Reference": 1, "c.1403C>A": 1}}	\N
6511804	6511090	c.2161G>A/c.2195T>G	{"DPYD": {"c.2161G>A": 1, "c.2195T>G": 1}}	\N
6511805	6511090	c.1260T>A/c.1577C>G	{"DPYD": {"c.1260T>A": 1, "c.1577C>G": 1}}	\N
6511806	6511090	c.1278G>T/c.1577C>G	{"DPYD": {"c.1278G>T": 1, "c.1577C>G": 1}}	\N
6511807	6511090	c.2161G>A/c.2657G>A (*9B)	{"DPYD": {"c.2161G>A": 1, "c.2657G>A (*9B)": 1}}	\N
6511808	6511090	c.1349C>T/c.2336C>A	{"DPYD": {"c.1349C>T": 1, "c.2336C>A": 1}}	\N
6511809	6511090	c.525G>A/c.1278G>T	{"DPYD": {"c.525G>A": 1, "c.1278G>T": 1}}	\N
6511810	6511090	c.46C>G/c.343A>G	{"DPYD": {"c.46C>G": 1, "c.343A>G": 1}}	\N
6511811	6511090	c.1294G>A/c.1905C>G	{"DPYD": {"c.1294G>A": 1, "c.1905C>G": 1}}	\N
6511812	6511090	c.2978T>G/Reference	{"DPYD": {"Reference": 1, "c.2978T>G": 1}}	\N
6511813	6511090	c.1577C>G/c.1627A>G (*5)	{"DPYD": {"c.1577C>G": 1, "c.1627A>G (*5)": 1}}	\N
6511814	6511090	c.46C>G/c.2921A>T	{"DPYD": {"c.46C>G": 1, "c.2921A>T": 1}}	\N
6511815	6511090	c.775A>G/c.3061G>C	{"DPYD": {"c.775A>G": 1, "c.3061G>C": 1}}	\N
6511816	6511090	c.967G>A/c.1627A>G (*5)	{"DPYD": {"c.967G>A": 1, "c.1627A>G (*5)": 1}}	\N
6511817	6511090	c.1108A>G/c.2303C>A	{"DPYD": {"c.1108A>G": 1, "c.2303C>A": 1}}	\N
6511818	6511090	c.1906A>C/Reference	{"DPYD": {"Reference": 1, "c.1906A>C": 1}}	\N
6511819	6511090	c.1108A>G/c.3067C>A	{"DPYD": {"c.1108A>G": 1, "c.3067C>A": 1}}	\N
6511820	6511090	c.2186C>T/Reference	{"DPYD": {"Reference": 1, "c.2186C>T": 1}}	\N
6511821	6511090	c.46C>G/c.313G>A	{"DPYD": {"c.46C>G": 1, "c.313G>A": 1}}	\N
6511822	6511090	c.1003G>T (*11)/c.2336C>A	{"DPYD": {"c.2336C>A": 1, "c.1003G>T (*11)": 1}}	\N
6511823	6511090	c.2582A>G/c.2977C>T	{"DPYD": {"c.2582A>G": 1, "c.2977C>T": 1}}	\N
6511824	6511090	c.62G>A/c.775A>G	{"DPYD": {"c.62G>A": 1, "c.775A>G": 1}}	\N
6511825	6511090	c.1260T>A/c.1371C>T	{"DPYD": {"c.1260T>A": 1, "c.1371C>T": 1}}	\N
6511826	6511090	c.498G>A/c.2482G>A	{"DPYD": {"c.498G>A": 1, "c.2482G>A": 1}}	\N
6511827	6511090	c.1577C>G/c.2186C>T	{"DPYD": {"c.1577C>G": 1, "c.2186C>T": 1}}	\N
6511828	6511090	c.1577C>G/c.1682G>T	{"DPYD": {"c.1577C>G": 1, "c.1682G>T": 1}}	\N
6511829	6511090	c.85T>C (*9A)/c.2978T>G	{"DPYD": {"c.2978T>G": 1, "c.85T>C (*9A)": 1}}	\N
6511830	6511090	c.1003G>T (*11)/c.1990G>T	{"DPYD": {"c.1990G>T": 1, "c.1003G>T (*11)": 1}}	\N
6511831	6511090	c.934C>T/c.1358C>G	{"DPYD": {"c.934C>T": 1, "c.1358C>G": 1}}	\N
6511832	6511090	c.1181G>T/c.1627A>G (*5)	{"DPYD": {"c.1181G>T": 1, "c.1627A>G (*5)": 1}}	\N
6511833	6511090	c.934C>T/c.1003G>T (*11)	{"DPYD": {"c.934C>T": 1, "c.1003G>T (*11)": 1}}	\N
6511834	6511090	c.1278G>T/c.1358C>G	{"DPYD": {"c.1278G>T": 1, "c.1358C>G": 1}}	\N
6511835	6511090	c.1260T>A/c.1358C>G	{"DPYD": {"c.1260T>A": 1, "c.1358C>G": 1}}	\N
6511836	6511090	c.1349C>T/c.2977C>T	{"DPYD": {"c.1349C>T": 1, "c.2977C>T": 1}}	\N
6511837	6511090	c.1371C>T/c.2482G>A	{"DPYD": {"c.1371C>T": 1, "c.2482G>A": 1}}	\N
6511838	6511090	c.1349C>T/c.1896T>C	{"DPYD": {"c.1349C>T": 1, "c.1896T>C": 1}}	\N
6511839	6511090	c.2161G>A/c.3049G>A	{"DPYD": {"c.2161G>A": 1, "c.3049G>A": 1}}	\N
6511840	6511090	c.451A>G/c.2978T>G	{"DPYD": {"c.451A>G": 1, "c.2978T>G": 1}}	\N
6511841	6511090	c.1371C>T/c.2656C>T	{"DPYD": {"c.1371C>T": 1, "c.2656C>T": 1}}	\N
6511842	6511090	c.1990G>T/c.2656C>T	{"DPYD": {"c.1990G>T": 1, "c.2656C>T": 1}}	\N
6511843	6511090	c.1682G>T/Reference	{"DPYD": {"Reference": 1, "c.1682G>T": 1}}	\N
6511844	6511090	c.2303C>A/c.2657G>A (*9B)	{"DPYD": {"c.2303C>A": 1, "c.2657G>A (*9B)": 1}}	\N
6511845	6511090	c.1349C>T/c.1990G>T	{"DPYD": {"c.1349C>T": 1, "c.1990G>T": 1}}	\N
6511846	6511090	c.62G>A/c.1905C>G	{"DPYD": {"c.62G>A": 1, "c.1905C>G": 1}}	\N
6511847	6511090	c.62G>A/c.2623A>C	{"DPYD": {"c.62G>A": 1, "c.2623A>C": 1}}	\N
6511848	6511090	c.1519G>A/c.1990G>T	{"DPYD": {"c.1519G>A": 1, "c.1990G>T": 1}}	\N
6511849	6511090	c.2921A>T/c.2978T>G	{"DPYD": {"c.2921A>T": 1, "c.2978T>G": 1}}	\N
6511850	6511090	c.929T>C/c.2194G>A (*6)	{"DPYD": {"c.929T>C": 1, "c.2194G>A (*6)": 1}}	\N
6511851	6511090	c.2582A>G/c.3061G>C	{"DPYD": {"c.2582A>G": 1, "c.3061G>C": 1}}	\N
6511852	6511090	c.1181G>T/c.1601G>A (*4)	{"DPYD": {"c.1181G>T": 1, "c.1601G>A (*4)": 1}}	\N
6511853	6511090	c.1543G>A/c.1543G>A	{"DPYD": {"c.1543G>A": 2}}	\N
6511854	6511090	c.451A>G/c.3049G>A	{"DPYD": {"c.451A>G": 1, "c.3049G>A": 1}}	\N
6511855	6511090	c.1181G>T/c.1682G>T	{"DPYD": {"c.1181G>T": 1, "c.1682G>T": 1}}	\N
6511856	6511090	c.1371C>T/c.1543G>A	{"DPYD": {"c.1371C>T": 1, "c.1543G>A": 1}}	\N
6511857	6511090	c.1180C>T/c.2161G>A	{"DPYD": {"c.1180C>T": 1, "c.2161G>A": 1}}	\N
6511858	6511090	c.62G>A/c.1627A>G (*5)	{"DPYD": {"c.62G>A": 1, "c.1627A>G (*5)": 1}}	\N
6511859	6511090	c.1218G>A/c.1358C>G	{"DPYD": {"c.1218G>A": 1, "c.1358C>G": 1}}	\N
6511860	6511090	c.967G>A/c.2915A>G	{"DPYD": {"c.967G>A": 1, "c.2915A>G": 1}}	\N
6511861	6511090	c.85T>C (*9A)/c.1349C>T	{"DPYD": {"c.1349C>T": 1, "c.85T>C (*9A)": 1}}	\N
6511862	6511090	c.1003G>T (*11)/c.1906A>C	{"DPYD": {"c.1906A>C": 1, "c.1003G>T (*11)": 1}}	\N
6511863	6511090	c.313G>A/c.1108A>G	{"DPYD": {"c.313G>A": 1, "c.1108A>G": 1}}	\N
6511864	6511090	c.775A>G/c.2582A>G	{"DPYD": {"c.775A>G": 1, "c.2582A>G": 1}}	\N
6511865	6511090	c.1601G>A (*4)/c.1796T>C	{"DPYD": {"c.1796T>C": 1, "c.1601G>A (*4)": 1}}	\N
6511866	6511090	c.2195T>G/c.2482G>A	{"DPYD": {"c.2195T>G": 1, "c.2482G>A": 1}}	\N
6511867	6511090	c.775A>G/c.1519G>A	{"DPYD": {"c.775A>G": 1, "c.1519G>A": 1}}	\N
6511868	6511090	c.496A>G/c.1108A>G	{"DPYD": {"c.496A>G": 1, "c.1108A>G": 1}}	\N
6511869	6511090	c.1403C>A/c.2921A>T	{"DPYD": {"c.1403C>A": 1, "c.2921A>T": 1}}	\N
6511870	6511090	c.46C>G/c.62G>A	{"DPYD": {"c.46C>G": 1, "c.62G>A": 1}}	\N
6511871	6511090	c.1543G>A/c.2656C>T	{"DPYD": {"c.1543G>A": 1, "c.2656C>T": 1}}	\N
6511872	6511090	c.525G>A/c.2194G>A (*6)	{"DPYD": {"c.525G>A": 1, "c.2194G>A (*6)": 1}}	\N
6511873	6511090	c.1543G>A/c.2582A>G	{"DPYD": {"c.1543G>A": 1, "c.2582A>G": 1}}	\N
6511874	6511090	c.929T>C/c.1906A>C	{"DPYD": {"c.929T>C": 1, "c.1906A>C": 1}}	\N
6511875	6511090	c.2186C>T/c.2977C>T	{"DPYD": {"c.2186C>T": 1, "c.2977C>T": 1}}	\N
6511876	6511090	c.1906A>C/c.2336C>A	{"DPYD": {"c.1906A>C": 1, "c.2336C>A": 1}}	\N
6511877	6511090	c.62G>A/c.343A>G	{"DPYD": {"c.62G>A": 1, "c.343A>G": 1}}	\N
6511878	6511090	c.1543G>A/c.1615G>A	{"DPYD": {"c.1543G>A": 1, "c.1615G>A": 1}}	\N
6511879	6511090	c.498G>A/c.3049G>A	{"DPYD": {"c.498G>A": 1, "c.3049G>A": 1}}	\N
6511880	6511090	c.1278G>T/c.1543G>A	{"DPYD": {"c.1278G>T": 1, "c.1543G>A": 1}}	\N
6511881	6511090	c.967G>A/c.1371C>T	{"DPYD": {"c.967G>A": 1, "c.1371C>T": 1}}	\N
6511882	6511090	c.2657G>A (*9B)/c.2977C>T	{"DPYD": {"c.2977C>T": 1, "c.2657G>A (*9B)": 1}}	\N
6511883	6511090	c.929T>C/c.3049G>A	{"DPYD": {"c.929T>C": 1, "c.3049G>A": 1}}	\N
6511884	6511090	c.934C>T/c.2977C>T	{"DPYD": {"c.934C>T": 1, "c.2977C>T": 1}}	\N
6511885	6511090	c.525G>A/c.1294G>A	{"DPYD": {"c.525G>A": 1, "c.1294G>A": 1}}	\N
6511886	6511090	c.2336C>A/c.2656C>T	{"DPYD": {"c.2336C>A": 1, "c.2656C>T": 1}}	\N
6511887	6511090	c.1371C>T/c.2336C>A	{"DPYD": {"c.1371C>T": 1, "c.2336C>A": 1}}	\N
6511888	6511090	c.451A>G/c.1349C>T	{"DPYD": {"c.451A>G": 1, "c.1349C>T": 1}}	\N
6511889	6511090	c.85T>C (*9A)/c.1601G>A (*4)	{"DPYD": {"c.85T>C (*9A)": 1, "c.1601G>A (*4)": 1}}	\N
6511890	6511090	c.775A>G/c.2978T>G	{"DPYD": {"c.775A>G": 1, "c.2978T>G": 1}}	\N
6511891	6511090	c.967G>A/c.2161G>A	{"DPYD": {"c.967G>A": 1, "c.2161G>A": 1}}	\N
6511892	6511090	c.1615G>A/c.2482G>A	{"DPYD": {"c.1615G>A": 1, "c.2482G>A": 1}}	\N
6511893	6511090	c.1627A>G (*5)/c.2656C>T	{"DPYD": {"c.2656C>T": 1, "c.1627A>G (*5)": 1}}	\N
6511894	6511090	c.1278G>T/c.3061G>C	{"DPYD": {"c.1278G>T": 1, "c.3061G>C": 1}}	\N
6511895	6511090	c.775A>G/c.2336C>A	{"DPYD": {"c.775A>G": 1, "c.2336C>A": 1}}	\N
6511896	6511090	c.2161G>A/c.2978T>G	{"DPYD": {"c.2161G>A": 1, "c.2978T>G": 1}}	\N
6511897	6511090	c.967G>A/c.1796T>C	{"DPYD": {"c.967G>A": 1, "c.1796T>C": 1}}	\N
6511898	6511090	c.1181G>T/c.1990G>T	{"DPYD": {"c.1181G>T": 1, "c.1990G>T": 1}}	\N
6511899	6511090	c.525G>A/c.1906A>C	{"DPYD": {"c.525G>A": 1, "c.1906A>C": 1}}	\N
6511900	6511090	c.2303C>A/c.2915A>G	{"DPYD": {"c.2303C>A": 1, "c.2915A>G": 1}}	\N
6511901	6511090	c.1260T>A/c.1403C>A	{"DPYD": {"c.1260T>A": 1, "c.1403C>A": 1}}	\N
6511902	6511090	c.2582A>G/c.2582A>G	{"DPYD": {"c.2582A>G": 2}}	\N
6511903	6511090	c.85T>C (*9A)/c.1577C>G	{"DPYD": {"c.1577C>G": 1, "c.85T>C (*9A)": 1}}	\N
6511904	6511090	c.1896T>C/c.1906A>C	{"DPYD": {"c.1896T>C": 1, "c.1906A>C": 1}}	\N
6511905	6511090	c.1218G>A/c.3067C>A	{"DPYD": {"c.1218G>A": 1, "c.3067C>A": 1}}	\N
6511906	6511090	c.1260T>A/c.2303C>A	{"DPYD": {"c.1260T>A": 1, "c.2303C>A": 1}}	\N
6511907	6511090	c.1108A>G/c.2656C>T	{"DPYD": {"c.1108A>G": 1, "c.2656C>T": 1}}	\N
6511908	6511090	c.1519G>A/c.2657G>A (*9B)	{"DPYD": {"c.1519G>A": 1, "c.2657G>A (*9B)": 1}}	\N
6511909	6511090	c.934C>T/c.1218G>A	{"DPYD": {"c.934C>T": 1, "c.1218G>A": 1}}	\N
6511910	6511090	c.498G>A/c.1906A>C	{"DPYD": {"c.498G>A": 1, "c.1906A>C": 1}}	\N
6511911	6511090	c.1218G>A/c.2303C>A	{"DPYD": {"c.1218G>A": 1, "c.2303C>A": 1}}	\N
6511912	6511090	c.62G>A/c.313G>A	{"DPYD": {"c.62G>A": 1, "c.313G>A": 1}}	\N
6511913	6511090	c.1906A>C/c.2978T>G	{"DPYD": {"c.1906A>C": 1, "c.2978T>G": 1}}	\N
6511914	6511090	c.1543G>A/c.2482G>A	{"DPYD": {"c.1543G>A": 1, "c.2482G>A": 1}}	\N
6511915	6511090	c.1896T>C/c.3049G>A	{"DPYD": {"c.1896T>C": 1, "c.3049G>A": 1}}	\N
6511916	6511090	c.934C>T/c.967G>A	{"DPYD": {"c.934C>T": 1, "c.967G>A": 1}}	\N
6511917	6511090	c.2195T>G/c.2656C>T	{"DPYD": {"c.2195T>G": 1, "c.2656C>T": 1}}	\N
6511918	6511090	c.1218G>A/c.1403C>A	{"DPYD": {"c.1218G>A": 1, "c.1403C>A": 1}}	\N
6511919	6511090	c.46C>G/c.3067C>A	{"DPYD": {"c.46C>G": 1, "c.3067C>A": 1}}	\N
6511920	6511090	c.1349C>T/Reference	{"DPYD": {"Reference": 1, "c.1349C>T": 1}}	\N
6511921	6511090	c.1358C>G/c.2977C>T	{"DPYD": {"c.1358C>G": 1, "c.2977C>T": 1}}	\N
6511922	6511090	c.1519G>A/c.1796T>C	{"DPYD": {"c.1519G>A": 1, "c.1796T>C": 1}}	\N
6511923	6511090	c.46C>G/c.1218G>A	{"DPYD": {"c.46C>G": 1, "c.1218G>A": 1}}	\N
6511924	6511090	c.2161G>A/c.2336C>A	{"DPYD": {"c.2161G>A": 1, "c.2336C>A": 1}}	\N
6511925	6511090	c.85T>C (*9A)/c.525G>A	{"DPYD": {"c.525G>A": 1, "c.85T>C (*9A)": 1}}	\N
6511926	6511090	c.451A>G/c.1627A>G (*5)	{"DPYD": {"c.451A>G": 1, "c.1627A>G (*5)": 1}}	\N
6511927	6511090	c.929T>C/c.2921A>T	{"DPYD": {"c.929T>C": 1, "c.2921A>T": 1}}	\N
6511928	6511090	c.496A>G/c.1403C>A	{"DPYD": {"c.496A>G": 1, "c.1403C>A": 1}}	\N
6511929	6511090	c.3061G>C/c.3061G>C	{"DPYD": {"c.3061G>C": 2}}	\N
6511930	6511090	c.1990G>T/c.2161G>A	{"DPYD": {"c.1990G>T": 1, "c.2161G>A": 1}}	\N
6511931	6511090	c.929T>C/c.1294G>A	{"DPYD": {"c.929T>C": 1, "c.1294G>A": 1}}	\N
6511932	6511090	c.1519G>A/c.2161G>A	{"DPYD": {"c.1519G>A": 1, "c.2161G>A": 1}}	\N
6511933	6511090	c.498G>A/c.1990G>T	{"DPYD": {"c.498G>A": 1, "c.1990G>T": 1}}	\N
6511934	6511090	c.1003G>T (*11)/c.2656C>T	{"DPYD": {"c.2656C>T": 1, "c.1003G>T (*11)": 1}}	\N
6511935	6511090	c.1278G>T/c.1682G>T	{"DPYD": {"c.1278G>T": 1, "c.1682G>T": 1}}	\N
6511936	6511090	c.498G>A/c.2194G>A (*6)	{"DPYD": {"c.498G>A": 1, "c.2194G>A (*6)": 1}}	\N
6511937	6511090	c.1349C>T/c.2482G>A	{"DPYD": {"c.1349C>T": 1, "c.2482G>A": 1}}	\N
6511938	6511090	c.2657G>A (*9B)/c.3067C>A	{"DPYD": {"c.3067C>A": 1, "c.2657G>A (*9B)": 1}}	\N
6511939	6511090	c.1349C>T/c.1577C>G	{"DPYD": {"c.1349C>T": 1, "c.1577C>G": 1}}	\N
6511940	6511090	c.1294G>A/c.2656C>T	{"DPYD": {"c.1294G>A": 1, "c.2656C>T": 1}}	\N
6511941	6511090	c.1896T>C/c.2921A>T	{"DPYD": {"c.1896T>C": 1, "c.2921A>T": 1}}	\N
6511942	6511090	c.967G>A/c.1682G>T	{"DPYD": {"c.967G>A": 1, "c.1682G>T": 1}}	\N
6511943	6511090	c.1403C>A/c.1403C>A	{"DPYD": {"c.1403C>A": 2}}	\N
6511944	6511090	c.85T>C (*9A)/Reference	{"DPYD": {"Reference": 1, "c.85T>C (*9A)": 1}}	\N
6511945	6511090	c.967G>A/c.1543G>A	{"DPYD": {"c.967G>A": 1, "c.1543G>A": 1}}	\N
6511946	6511090	c.967G>A/c.2657G>A (*9B)	{"DPYD": {"c.967G>A": 1, "c.2657G>A (*9B)": 1}}	\N
6511947	6511090	c.85T>C (*9A)/c.2582A>G	{"DPYD": {"c.2582A>G": 1, "c.85T>C (*9A)": 1}}	\N
6511948	6511090	c.1181G>T/c.1519G>A	{"DPYD": {"c.1181G>T": 1, "c.1519G>A": 1}}	\N
6511949	6511090	c.1180C>T/c.1403C>A	{"DPYD": {"c.1180C>T": 1, "c.1403C>A": 1}}	\N
6511950	6511090	c.525G>A/c.775A>G	{"DPYD": {"c.525G>A": 1, "c.775A>G": 1}}	\N
6511951	6511090	c.967G>A/c.1358C>G	{"DPYD": {"c.967G>A": 1, "c.1358C>G": 1}}	\N
6511952	6511090	c.775A>G/c.1627A>G (*5)	{"DPYD": {"c.775A>G": 1, "c.1627A>G (*5)": 1}}	\N
6511953	6511090	c.496A>G/c.1349C>T	{"DPYD": {"c.496A>G": 1, "c.1349C>T": 1}}	\N
6511954	6511090	c.1181G>T/c.2921A>T	{"DPYD": {"c.1181G>T": 1, "c.2921A>T": 1}}	\N
6511955	6511090	c.85T>C (*9A)/c.2482G>A	{"DPYD": {"c.2482G>A": 1, "c.85T>C (*9A)": 1}}	\N
6511956	6511090	c.1349C>T/c.2582A>G	{"DPYD": {"c.1349C>T": 1, "c.2582A>G": 1}}	\N
6511957	6511090	c.1180C>T/c.2303C>A	{"DPYD": {"c.1180C>T": 1, "c.2303C>A": 1}}	\N
6511958	6511090	c.525G>A/c.2921A>T	{"DPYD": {"c.525G>A": 1, "c.2921A>T": 1}}	\N
6511959	6511090	c.62G>A/c.967G>A	{"DPYD": {"c.62G>A": 1, "c.967G>A": 1}}	\N
6511960	6511090	c.451A>G/c.1260T>A	{"DPYD": {"c.451A>G": 1, "c.1260T>A": 1}}	\N
6511961	6511090	c.1577C>G/c.2623A>C	{"DPYD": {"c.1577C>G": 1, "c.2623A>C": 1}}	\N
6511962	6511090	c.2186C>T/c.3067C>A	{"DPYD": {"c.2186C>T": 1, "c.3067C>A": 1}}	\N
6511963	6511090	c.525G>A/c.3049G>A	{"DPYD": {"c.525G>A": 1, "c.3049G>A": 1}}	\N
6511964	6511090	c.1615G>A/c.2623A>C	{"DPYD": {"c.1615G>A": 1, "c.2623A>C": 1}}	\N
6511965	6511090	c.313G>A/c.1896T>C	{"DPYD": {"c.313G>A": 1, "c.1896T>C": 1}}	\N
6511966	6511090	c.2186C>T/c.2303C>A	{"DPYD": {"c.2186C>T": 1, "c.2303C>A": 1}}	\N
6511967	6511090	c.1577C>G/c.1896T>C	{"DPYD": {"c.1577C>G": 1, "c.1896T>C": 1}}	\N
6511968	6511090	c.313G>A/c.2623A>C	{"DPYD": {"c.313G>A": 1, "c.2623A>C": 1}}	\N
6511969	6511090	c.313G>A/c.1905C>G	{"DPYD": {"c.313G>A": 1, "c.1905C>G": 1}}	\N
6511970	6511090	c.313G>A/c.929T>C	{"DPYD": {"c.313G>A": 1, "c.929T>C": 1}}	\N
6511971	6511090	c.1577C>G/c.1905C>G	{"DPYD": {"c.1577C>G": 1, "c.1905C>G": 1}}	\N
6511972	6511090	c.1543G>A/c.1577C>G	{"DPYD": {"c.1543G>A": 1, "c.1577C>G": 1}}	\N
6511973	6511090	c.1371C>T/c.2978T>G	{"DPYD": {"c.1371C>T": 1, "c.2978T>G": 1}}	\N
6511974	6511090	c.46C>G/c.2977C>T	{"DPYD": {"c.46C>G": 1, "c.2977C>T": 1}}	\N
6511975	6511090	c.2977C>T/Reference	{"DPYD": {"Reference": 1, "c.2977C>T": 1}}	\N
6511976	6511090	c.62G>A/c.2582A>G	{"DPYD": {"c.62G>A": 1, "c.2582A>G": 1}}	\N
6511977	6511090	c.496A>G/c.2303C>A	{"DPYD": {"c.496A>G": 1, "c.2303C>A": 1}}	\N
6511978	6511090	c.1278G>T/c.2978T>G	{"DPYD": {"c.1278G>T": 1, "c.2978T>G": 1}}	\N
6511979	6511090	c.775A>G/c.2915A>G	{"DPYD": {"c.775A>G": 1, "c.2915A>G": 1}}	\N
6511980	6511090	c.1990G>T/c.3061G>C	{"DPYD": {"c.1990G>T": 1, "c.3061G>C": 1}}	\N
6511981	6511090	c.1519G>A/c.3061G>C	{"DPYD": {"c.1519G>A": 1, "c.3061G>C": 1}}	\N
6511982	6511090	c.1218G>A/c.1218G>A	{"DPYD": {"c.1218G>A": 2}}	\N
6511983	6511090	c.85T>C (*9A)/c.1181G>T	{"DPYD": {"c.1181G>T": 1, "c.85T>C (*9A)": 1}}	\N
6511984	6511090	c.1358C>G/c.3067C>A	{"DPYD": {"c.1358C>G": 1, "c.3067C>A": 1}}	\N
6511985	6511090	c.1181G>T/c.2194G>A (*6)	{"DPYD": {"c.1181G>T": 1, "c.2194G>A (*6)": 1}}	\N
6511986	6511090	c.313G>A/c.934C>T	{"DPYD": {"c.313G>A": 1, "c.934C>T": 1}}	\N
6511987	6511090	c.1796T>C/c.2303C>A	{"DPYD": {"c.1796T>C": 1, "c.2303C>A": 1}}	\N
6511988	6511090	c.1615G>A/c.1896T>C	{"DPYD": {"c.1615G>A": 1, "c.1896T>C": 1}}	\N
6511989	6511090	c.1796T>C/c.2195T>G	{"DPYD": {"c.1796T>C": 1, "c.2195T>G": 1}}	\N
6511990	6511090	c.525G>A/c.1108A>G	{"DPYD": {"c.525G>A": 1, "c.1108A>G": 1}}	\N
6511991	6511090	c.313G>A/c.525G>A	{"DPYD": {"c.313G>A": 1, "c.525G>A": 1}}	\N
6511992	6511090	c.1906A>C/c.3061G>C	{"DPYD": {"c.1906A>C": 1, "c.3061G>C": 1}}	\N
6511993	6511090	c.496A>G/c.2915A>G	{"DPYD": {"c.496A>G": 1, "c.2915A>G": 1}}	\N
6511994	6511090	c.85T>C (*9A)/c.1905C>G	{"DPYD": {"c.1905C>G": 1, "c.85T>C (*9A)": 1}}	\N
6511995	6511090	c.1278G>T/c.1796T>C	{"DPYD": {"c.1278G>T": 1, "c.1796T>C": 1}}	\N
6511996	6511090	c.2336C>A/c.2921A>T	{"DPYD": {"c.2336C>A": 1, "c.2921A>T": 1}}	\N
6511997	6511090	c.62G>A/c.3067C>A	{"DPYD": {"c.62G>A": 1, "c.3067C>A": 1}}	\N
6511998	6511090	c.1180C>T/c.1349C>T	{"DPYD": {"c.1180C>T": 1, "c.1349C>T": 1}}	\N
6511999	6511090	c.1601G>A (*4)/c.1906A>C	{"DPYD": {"c.1906A>C": 1, "c.1601G>A (*4)": 1}}	\N
6512000	6511090	c.1796T>C/c.3067C>A	{"DPYD": {"c.1796T>C": 1, "c.3067C>A": 1}}	\N
6512001	6511090	c.1682G>T/c.3067C>A	{"DPYD": {"c.1682G>T": 1, "c.3067C>A": 1}}	\N
6512002	6511090	c.1627A>G (*5)/c.1990G>T	{"DPYD": {"c.1990G>T": 1, "c.1627A>G (*5)": 1}}	\N
6512003	6511090	c.934C>T/c.1403C>A	{"DPYD": {"c.934C>T": 1, "c.1403C>A": 1}}	\N
6512004	6511090	c.1615G>A/c.2195T>G	{"DPYD": {"c.1615G>A": 1, "c.2195T>G": 1}}	\N
6512005	6511090	c.496A>G/c.3067C>A	{"DPYD": {"c.496A>G": 1, "c.3067C>A": 1}}	\N
6512006	6511090	c.1108A>G/c.1519G>A	{"DPYD": {"c.1108A>G": 1, "c.1519G>A": 1}}	\N
6512007	6511090	c.62G>A/c.2195T>G	{"DPYD": {"c.62G>A": 1, "c.2195T>G": 1}}	\N
6512008	6511090	c.1180C>T/c.1260T>A	{"DPYD": {"c.1180C>T": 1, "c.1260T>A": 1}}	\N
6512009	6511090	c.1181G>T/c.3049G>A	{"DPYD": {"c.1181G>T": 1, "c.3049G>A": 1}}	\N
6512010	6511090	c.2656C>T/c.2978T>G	{"DPYD": {"c.2656C>T": 1, "c.2978T>G": 1}}	\N
6512011	6511090	c.1181G>T/c.1906A>C	{"DPYD": {"c.1181G>T": 1, "c.1906A>C": 1}}	\N
6512012	6511090	c.1358C>G/c.2582A>G	{"DPYD": {"c.1358C>G": 1, "c.2582A>G": 1}}	\N
6512013	6511090	c.1543G>A/c.1896T>C	{"DPYD": {"c.1543G>A": 1, "c.1896T>C": 1}}	\N
6512014	6511090	c.525G>A/c.1519G>A	{"DPYD": {"c.525G>A": 1, "c.1519G>A": 1}}	\N
6512015	6511090	c.1349C>T/c.1905C>G	{"DPYD": {"c.1349C>T": 1, "c.1905C>G": 1}}	\N
6512016	6511090	c.1577C>G/c.1577C>G	{"DPYD": {"c.1577C>G": 2}}	\N
6512017	6511090	c.1519G>A/c.1682G>T	{"DPYD": {"c.1519G>A": 1, "c.1682G>T": 1}}	\N
6512018	6511090	c.2195T>G/c.2657G>A (*9B)	{"DPYD": {"c.2195T>G": 1, "c.2657G>A (*9B)": 1}}	\N
6512019	6511090	c.2915A>G/c.2977C>T	{"DPYD": {"c.2915A>G": 1, "c.2977C>T": 1}}	\N
6512020	6511090	c.46C>G/c.2303C>A	{"DPYD": {"c.46C>G": 1, "c.2303C>A": 1}}	\N
6512021	6511090	c.1905C>G/c.2915A>G	{"DPYD": {"c.1905C>G": 1, "c.2915A>G": 1}}	\N
6512022	6511090	c.451A>G/c.1403C>A	{"DPYD": {"c.451A>G": 1, "c.1403C>A": 1}}	\N
6512023	6511090	c.1601G>A (*4)/c.3049G>A	{"DPYD": {"c.3049G>A": 1, "c.1601G>A (*4)": 1}}	\N
6512024	6511090	c.929T>C/c.1519G>A	{"DPYD": {"c.929T>C": 1, "c.1519G>A": 1}}	\N
6512025	6511090	c.1349C>T/c.2623A>C	{"DPYD": {"c.1349C>T": 1, "c.2623A>C": 1}}	\N
6512026	6511090	c.2161G>A/c.2915A>G	{"DPYD": {"c.2161G>A": 1, "c.2915A>G": 1}}	\N
6512027	6511090	c.1601G>A (*4)/c.2194G>A (*6)	{"DPYD": {"c.1601G>A (*4)": 1, "c.2194G>A (*6)": 1}}	\N
6512028	6511090	c.1003G>T (*11)/c.1519G>A	{"DPYD": {"c.1519G>A": 1, "c.1003G>T (*11)": 1}}	\N
6512029	6511090	c.1896T>C/c.2194G>A (*6)	{"DPYD": {"c.1896T>C": 1, "c.2194G>A (*6)": 1}}	\N
6512030	6511090	c.934C>T/c.1181G>T	{"DPYD": {"c.934C>T": 1, "c.1181G>T": 1}}	\N
6512031	6511090	c.2656C>T/c.3061G>C	{"DPYD": {"c.2656C>T": 1, "c.3061G>C": 1}}	\N
6512032	6511090	c.46C>G/c.967G>A	{"DPYD": {"c.46C>G": 1, "c.967G>A": 1}}	\N
6512033	6511090	c.967G>A/c.3061G>C	{"DPYD": {"c.967G>A": 1, "c.3061G>C": 1}}	\N
6512034	6511090	c.775A>G/c.1358C>G	{"DPYD": {"c.775A>G": 1, "c.1358C>G": 1}}	\N
6512035	6511090	c.1519G>A/c.2656C>T	{"DPYD": {"c.1519G>A": 1, "c.2656C>T": 1}}	\N
6512036	6511090	c.1294G>A/c.1519G>A	{"DPYD": {"c.1294G>A": 1, "c.1519G>A": 1}}	\N
6512037	6511090	c.498G>A/c.498G>A	{"DPYD": {"c.498G>A": 2}}	\N
6512038	6511090	c.929T>C/c.2656C>T	{"DPYD": {"c.929T>C": 1, "c.2656C>T": 1}}	\N
6512039	6511090	c.1601G>A (*4)/c.1990G>T	{"DPYD": {"c.1990G>T": 1, "c.1601G>A (*4)": 1}}	\N
6512040	6511090	c.1896T>C/c.1990G>T	{"DPYD": {"c.1896T>C": 1, "c.1990G>T": 1}}	\N
6512041	6511090	c.62G>A/c.2977C>T	{"DPYD": {"c.62G>A": 1, "c.2977C>T": 1}}	\N
6512042	6511090	c.1294G>A/c.2921A>T	{"DPYD": {"c.1294G>A": 1, "c.2921A>T": 1}}	\N
6512043	6511090	c.498G>A/c.775A>G	{"DPYD": {"c.498G>A": 1, "c.775A>G": 1}}	\N
6512044	6511090	c.1627A>G (*5)/c.2194G>A (*6)	{"DPYD": {"c.1627A>G (*5)": 1, "c.2194G>A (*6)": 1}}	\N
6512045	6511090	c.85T>C (*9A)/c.2623A>C	{"DPYD": {"c.2623A>C": 1, "c.85T>C (*9A)": 1}}	\N
6512046	6511090	c.929T>C/c.1108A>G	{"DPYD": {"c.929T>C": 1, "c.1108A>G": 1}}	\N
6512047	6511090	c.1682G>T/c.2303C>A	{"DPYD": {"c.1682G>T": 1, "c.2303C>A": 1}}	\N
6512048	6511090	c.62G>A/c.2303C>A	{"DPYD": {"c.62G>A": 1, "c.2303C>A": 1}}	\N
6512049	6511090	c.85T>C (*9A)/c.343A>G	{"DPYD": {"c.343A>G": 1, "c.85T>C (*9A)": 1}}	\N
6512050	6511090	c.343A>G/c.343A>G	{"DPYD": {"c.343A>G": 2}}	\N
6512051	6511090	c.343A>G/c.1218G>A	{"DPYD": {"c.343A>G": 1, "c.1218G>A": 1}}	\N
6512052	6511090	c.85T>C (*9A)/c.1615G>A	{"DPYD": {"c.1615G>A": 1, "c.85T>C (*9A)": 1}}	\N
6512053	6511090	c.1796T>C/c.2977C>T	{"DPYD": {"c.1796T>C": 1, "c.2977C>T": 1}}	\N
6512054	6511090	c.1519G>A/c.1543G>A	{"DPYD": {"c.1519G>A": 1, "c.1543G>A": 1}}	\N
6512055	6511090	c.451A>G/c.2915A>G	{"DPYD": {"c.451A>G": 1, "c.2915A>G": 1}}	\N
6512056	6511090	c.967G>A/c.2978T>G	{"DPYD": {"c.967G>A": 1, "c.2978T>G": 1}}	\N
6512057	6511090	c.343A>G/c.1403C>A	{"DPYD": {"c.343A>G": 1, "c.1403C>A": 1}}	\N
6512058	6511090	c.313G>A/c.1278G>T	{"DPYD": {"c.313G>A": 1, "c.1278G>T": 1}}	\N
6512059	6511090	c.1403C>A/c.2915A>G	{"DPYD": {"c.1403C>A": 1, "c.2915A>G": 1}}	\N
6512060	6511090	c.1990G>T/c.2657G>A (*9B)	{"DPYD": {"c.1990G>T": 1, "c.2657G>A (*9B)": 1}}	\N
6512061	6511090	c.1349C>T/c.1615G>A	{"DPYD": {"c.1349C>T": 1, "c.1615G>A": 1}}	\N
6512062	6511090	c.2336C>A/c.3049G>A	{"DPYD": {"c.2336C>A": 1, "c.3049G>A": 1}}	\N
6512063	6511090	c.1260T>A/c.1260T>A	{"DPYD": {"c.1260T>A": 2}}	\N
6512064	6511090	c.1349C>T/c.1601G>A (*4)	{"DPYD": {"c.1349C>T": 1, "c.1601G>A (*4)": 1}}	\N
6512065	6511090	c.1627A>G (*5)/c.1906A>C	{"DPYD": {"c.1906A>C": 1, "c.1627A>G (*5)": 1}}	\N
6512066	6511090	c.2915A>G/c.3067C>A	{"DPYD": {"c.2915A>G": 1, "c.3067C>A": 1}}	\N
6512067	6511090	c.2482G>A/Reference	{"DPYD": {"Reference": 1, "c.2482G>A": 1}}	\N
6512068	6511090	c.313G>A/c.1003G>T (*11)	{"DPYD": {"c.313G>A": 1, "c.1003G>T (*11)": 1}}	\N
6512069	6511090	c.1543G>A/c.2195T>G	{"DPYD": {"c.1543G>A": 1, "c.2195T>G": 1}}	\N
6512070	6511090	c.62G>A/c.1403C>A	{"DPYD": {"c.62G>A": 1, "c.1403C>A": 1}}	\N
6512071	6511090	c.3049G>A/c.3049G>A	{"DPYD": {"c.3049G>A": 2}}	\N
6512072	6511090	c.2186C>T/c.2482G>A	{"DPYD": {"c.2186C>T": 1, "c.2482G>A": 1}}	\N
6512073	6511090	c.1577C>G/c.2195T>G	{"DPYD": {"c.1577C>G": 1, "c.2195T>G": 1}}	\N
6512074	6511090	c.1294G>A/c.3061G>C	{"DPYD": {"c.1294G>A": 1, "c.3061G>C": 1}}	\N
6512075	6511090	c.1003G>T (*11)/c.3049G>A	{"DPYD": {"c.3049G>A": 1, "c.1003G>T (*11)": 1}}	\N
6512076	6511090	c.313G>A/c.1615G>A	{"DPYD": {"c.313G>A": 1, "c.1615G>A": 1}}	\N
6512077	6511090	c.62G>A/c.934C>T	{"DPYD": {"c.62G>A": 1, "c.934C>T": 1}}	\N
6512078	6511090	c.1218G>A/c.2915A>G	{"DPYD": {"c.1218G>A": 1, "c.2915A>G": 1}}	\N
6512079	6511090	c.1003G>T (*11)/c.1682G>T	{"DPYD": {"c.1682G>T": 1, "c.1003G>T (*11)": 1}}	\N
6512080	6511090	c.1615G>A/c.2977C>T	{"DPYD": {"c.1615G>A": 1, "c.2977C>T": 1}}	\N
6512081	6511090	c.1905C>G/c.3067C>A	{"DPYD": {"c.1905C>G": 1, "c.3067C>A": 1}}	\N
6512082	6511090	c.967G>A/c.2656C>T	{"DPYD": {"c.967G>A": 1, "c.2656C>T": 1}}	\N
6512083	6511090	c.85T>C (*9A)/c.2186C>T	{"DPYD": {"c.2186C>T": 1, "c.85T>C (*9A)": 1}}	\N
6512084	6511090	c.1278G>T/c.1627A>G (*5)	{"DPYD": {"c.1278G>T": 1, "c.1627A>G (*5)": 1}}	\N
6512085	6511090	c.525G>A/c.2656C>T	{"DPYD": {"c.525G>A": 1, "c.2656C>T": 1}}	\N
6512086	6511090	c.1294G>A/c.1358C>G	{"DPYD": {"c.1294G>A": 1, "c.1358C>G": 1}}	\N
6512087	6511090	c.1615G>A/c.2186C>T	{"DPYD": {"c.1615G>A": 1, "c.2186C>T": 1}}	\N
6512088	6511090	c.1108A>G/c.1906A>C	{"DPYD": {"c.1108A>G": 1, "c.1906A>C": 1}}	\N
6512089	6511090	c.1260T>A/c.2915A>G	{"DPYD": {"c.1260T>A": 1, "c.2915A>G": 1}}	\N
6512090	6511090	c.1294G>A/c.1906A>C	{"DPYD": {"c.1294G>A": 1, "c.1906A>C": 1}}	\N
6512091	6511090	c.1358C>G/c.1601G>A (*4)	{"DPYD": {"c.1358C>G": 1, "c.1601G>A (*4)": 1}}	\N
6512092	6511090	c.775A>G/c.1796T>C	{"DPYD": {"c.775A>G": 1, "c.1796T>C": 1}}	\N
6512093	6511090	c.85T>C (*9A)/c.967G>A	{"DPYD": {"c.967G>A": 1, "c.85T>C (*9A)": 1}}	\N
6512094	6511090	c.525G>A/c.2186C>T	{"DPYD": {"c.525G>A": 1, "c.2186C>T": 1}}	\N
6512095	6511090	c.313G>A/c.2582A>G	{"DPYD": {"c.313G>A": 1, "c.2582A>G": 1}}	\N
6512096	6511090	c.343A>G/c.2915A>G	{"DPYD": {"c.343A>G": 1, "c.2915A>G": 1}}	\N
6512097	6511090	c.2194G>A (*6)/c.2194G>A (*6)	{"DPYD": {"c.2194G>A (*6)": 2}}	\N
6512098	6511090	c.1108A>G/c.1371C>T	{"DPYD": {"c.1108A>G": 1, "c.1371C>T": 1}}	\N
6512099	6511090	c.313G>A/c.775A>G	{"DPYD": {"c.313G>A": 1, "c.775A>G": 1}}	\N
6512100	6511090	c.1403C>A/c.2978T>G	{"DPYD": {"c.1403C>A": 1, "c.2978T>G": 1}}	\N
6512101	6511090	c.46C>G/c.1577C>G	{"DPYD": {"c.46C>G": 1, "c.1577C>G": 1}}	\N
6512102	6511090	c.1627A>G (*5)/c.2161G>A	{"DPYD": {"c.2161G>A": 1, "c.1627A>G (*5)": 1}}	\N
6512103	6511090	c.1108A>G/c.1294G>A	{"DPYD": {"c.1108A>G": 1, "c.1294G>A": 1}}	\N
6512104	6511090	c.934C>T/c.1615G>A	{"DPYD": {"c.934C>T": 1, "c.1615G>A": 1}}	\N
6512105	6511090	c.2194G>A (*6)/c.2582A>G	{"DPYD": {"c.2582A>G": 1, "c.2194G>A (*6)": 1}}	\N
6512106	6511090	c.1218G>A/c.2195T>G	{"DPYD": {"c.1218G>A": 1, "c.2195T>G": 1}}	\N
6512107	6511090	c.1601G>A (*4)/c.1905C>G	{"DPYD": {"c.1905C>G": 1, "c.1601G>A (*4)": 1}}	\N
6512108	6511090	c.1543G>A/c.1905C>G	{"DPYD": {"c.1543G>A": 1, "c.1905C>G": 1}}	\N
6512109	6511090	c.313G>A/c.1294G>A	{"DPYD": {"c.313G>A": 1, "c.1294G>A": 1}}	\N
6512110	6511090	c.1543G>A/c.2977C>T	{"DPYD": {"c.1543G>A": 1, "c.2977C>T": 1}}	\N
6512111	6511090	c.62G>A/c.525G>A	{"DPYD": {"c.62G>A": 1, "c.525G>A": 1}}	\N
6512112	6511090	c.85T>C (*9A)/c.313G>A	{"DPYD": {"c.313G>A": 1, "c.85T>C (*9A)": 1}}	\N
6512113	6511090	c.1278G>T/c.2915A>G	{"DPYD": {"c.1278G>T": 1, "c.2915A>G": 1}}	\N
6512114	6511090	c.1260T>A/c.1627A>G (*5)	{"DPYD": {"c.1260T>A": 1, "c.1627A>G (*5)": 1}}	\N
6512115	6511090	c.1294G>A/c.1543G>A	{"DPYD": {"c.1294G>A": 1, "c.1543G>A": 1}}	\N
6512116	6511090	c.1218G>A/c.1627A>G (*5)	{"DPYD": {"c.1218G>A": 1, "c.1627A>G (*5)": 1}}	\N
6512117	6511090	c.2303C>A/c.3061G>C	{"DPYD": {"c.2303C>A": 1, "c.3061G>C": 1}}	\N
6512118	6511090	c.2656C>T/c.2915A>G	{"DPYD": {"c.2656C>T": 1, "c.2915A>G": 1}}	\N
6512119	6511090	c.1108A>G/c.1796T>C	{"DPYD": {"c.1108A>G": 1, "c.1796T>C": 1}}	\N
6512120	6511090	c.313G>A/c.1181G>T	{"DPYD": {"c.313G>A": 1, "c.1181G>T": 1}}	\N
6512121	6511090	c.1371C>T/c.1371C>T	{"DPYD": {"c.1371C>T": 2}}	\N
6512122	6511090	c.46C>G/c.2195T>G	{"DPYD": {"c.46C>G": 1, "c.2195T>G": 1}}	\N
6512123	6511090	c.498G>A/c.929T>C	{"DPYD": {"c.498G>A": 1, "c.929T>C": 1}}	\N
6512124	6511090	c.2161G>A/c.3061G>C	{"DPYD": {"c.2161G>A": 1, "c.3061G>C": 1}}	\N
6512125	6511090	c.1218G>A/c.1615G>A	{"DPYD": {"c.1218G>A": 1, "c.1615G>A": 1}}	\N
6512126	6511090	c.2336C>A/c.2657G>A (*9B)	{"DPYD": {"c.2336C>A": 1, "c.2657G>A (*9B)": 1}}	\N
6512127	6511090	c.775A>G/c.1349C>T	{"DPYD": {"c.775A>G": 1, "c.1349C>T": 1}}	\N
6512128	6511090	c.1358C>G/Reference	{"DPYD": {"Reference": 1, "c.1358C>G": 1}}	\N
6512129	6511090	c.62G>A/c.1577C>G	{"DPYD": {"c.62G>A": 1, "c.1577C>G": 1}}	\N
6512130	6511090	c.1294G>A/c.1990G>T	{"DPYD": {"c.1294G>A": 1, "c.1990G>T": 1}}	\N
6512131	6511090	c.451A>G/c.2336C>A	{"DPYD": {"c.451A>G": 1, "c.2336C>A": 1}}	\N
6512132	6511090	c.1294G>A/c.1371C>T	{"DPYD": {"c.1294G>A": 1, "c.1371C>T": 1}}	\N
6512133	6511090	c.1278G>T/c.2657G>A (*9B)	{"DPYD": {"c.1278G>T": 1, "c.2657G>A (*9B)": 1}}	\N
6512134	6511090	c.1371C>T/c.2161G>A	{"DPYD": {"c.1371C>T": 1, "c.2161G>A": 1}}	\N
6512135	6511090	c.1543G>A/c.2623A>C	{"DPYD": {"c.1543G>A": 1, "c.2623A>C": 1}}	\N
6512136	6511090	c.775A>G/c.2657G>A (*9B)	{"DPYD": {"c.775A>G": 1, "c.2657G>A (*9B)": 1}}	\N
6512137	6511090	c.1682G>T/c.2978T>G	{"DPYD": {"c.1682G>T": 1, "c.2978T>G": 1}}	\N
6512138	6511090	c.1601G>A (*4)/c.2921A>T	{"DPYD": {"c.2921A>T": 1, "c.1601G>A (*4)": 1}}	\N
6512139	6511090	c.1218G>A/c.1349C>T	{"DPYD": {"c.1218G>A": 1, "c.1349C>T": 1}}	\N
6512140	6511090	c.1260T>A/c.1349C>T	{"DPYD": {"c.1260T>A": 1, "c.1349C>T": 1}}	\N
6512141	6511090	c.1180C>T/c.2336C>A	{"DPYD": {"c.1180C>T": 1, "c.2336C>A": 1}}	\N
6512142	6511090	c.525G>A/c.1180C>T	{"DPYD": {"c.525G>A": 1, "c.1180C>T": 1}}	\N
6512143	6511090	c.929T>C/c.1180C>T	{"DPYD": {"c.929T>C": 1, "c.1180C>T": 1}}	\N
6512144	6511090	c.1180C>T/c.2977C>T	{"DPYD": {"c.1180C>T": 1, "c.2977C>T": 1}}	\N
6512145	6511090	c.775A>G/c.1403C>A	{"DPYD": {"c.775A>G": 1, "c.1403C>A": 1}}	\N
6512146	6511090	c.2656C>T/c.2657G>A (*9B)	{"DPYD": {"c.2656C>T": 1, "c.2657G>A (*9B)": 1}}	\N
6512147	6511090	c.1371C>T/c.2915A>G	{"DPYD": {"c.1371C>T": 1, "c.2915A>G": 1}}	\N
6512148	6511090	c.1601G>A (*4)/c.2186C>T	{"DPYD": {"c.2186C>T": 1, "c.1601G>A (*4)": 1}}	\N
6512149	6511090	c.62G>A/c.2482G>A	{"DPYD": {"c.62G>A": 1, "c.2482G>A": 1}}	\N
6512150	6511090	c.1108A>G/c.2921A>T	{"DPYD": {"c.1108A>G": 1, "c.2921A>T": 1}}	\N
6512151	6511090	c.2195T>G/c.3061G>C	{"DPYD": {"c.2195T>G": 1, "c.3061G>C": 1}}	\N
6512152	6511090	c.1990G>T/c.2921A>T	{"DPYD": {"c.1990G>T": 1, "c.2921A>T": 1}}	\N
6512153	6511090	c.934C>T/c.1349C>T	{"DPYD": {"c.934C>T": 1, "c.1349C>T": 1}}	\N
6512154	6511090	c.1358C>G/c.1615G>A	{"DPYD": {"c.1358C>G": 1, "c.1615G>A": 1}}	\N
6512155	6511090	c.1403C>A/c.3067C>A	{"DPYD": {"c.1403C>A": 1, "c.3067C>A": 1}}	\N
6512156	6511090	c.1180C>T/c.1218G>A	{"DPYD": {"c.1180C>T": 1, "c.1218G>A": 1}}	\N
6512157	6511090	c.1796T>C/c.2482G>A	{"DPYD": {"c.1796T>C": 1, "c.2482G>A": 1}}	\N
6512158	6511090	c.1108A>G/c.3061G>C	{"DPYD": {"c.1108A>G": 1, "c.3061G>C": 1}}	\N
6512159	6511090	c.496A>G/c.2977C>T	{"DPYD": {"c.496A>G": 1, "c.2977C>T": 1}}	\N
6512160	6511090	c.929T>C/c.2186C>T	{"DPYD": {"c.929T>C": 1, "c.2186C>T": 1}}	\N
6512161	6511090	c.934C>T/c.934C>T	{"DPYD": {"c.934C>T": 2}}	\N
6512162	6511090	c.1294G>A/c.1796T>C	{"DPYD": {"c.1294G>A": 1, "c.1796T>C": 1}}	\N
6512163	6511090	c.1615G>A/c.1905C>G	{"DPYD": {"c.1615G>A": 1, "c.1905C>G": 1}}	\N
6512164	6511090	c.2623A>C/c.3049G>A	{"DPYD": {"c.2623A>C": 1, "c.3049G>A": 1}}	\N
6512165	6511090	c.2623A>C/c.2623A>C	{"DPYD": {"c.2623A>C": 2}}	\N
6512166	6511090	c.2186C>T/c.2195T>G	{"DPYD": {"c.2186C>T": 1, "c.2195T>G": 1}}	\N
6512167	6511090	c.1543G>A/c.2186C>T	{"DPYD": {"c.1543G>A": 1, "c.2186C>T": 1}}	\N
6512168	6511090	c.1278G>T/c.1349C>T	{"DPYD": {"c.1278G>T": 1, "c.1349C>T": 1}}	\N
6512169	6511090	c.46C>G/c.934C>T	{"DPYD": {"c.46C>G": 1, "c.934C>T": 1}}	\N
6512170	6511090	c.1358C>G/c.2303C>A	{"DPYD": {"c.1358C>G": 1, "c.2303C>A": 1}}	\N
6512171	6511090	c.46C>G/c.1349C>T	{"DPYD": {"c.46C>G": 1, "c.1349C>T": 1}}	\N
6512172	6511090	c.967G>A/c.2336C>A	{"DPYD": {"c.967G>A": 1, "c.2336C>A": 1}}	\N
6512173	6511090	c.2582A>G/c.3067C>A	{"DPYD": {"c.2582A>G": 1, "c.3067C>A": 1}}	\N
6512174	6511090	c.2482G>A/c.2623A>C	{"DPYD": {"c.2482G>A": 1, "c.2623A>C": 1}}	\N
6512175	6511090	c.1358C>G/c.2195T>G	{"DPYD": {"c.1358C>G": 1, "c.2195T>G": 1}}	\N
6512176	6511090	c.2482G>A/c.3049G>A	{"DPYD": {"c.2482G>A": 1, "c.3049G>A": 1}}	\N
6512177	6511090	c.1519G>A/c.2978T>G	{"DPYD": {"c.1519G>A": 1, "c.2978T>G": 1}}	\N
6512178	6511090	c.1371C>T/c.3061G>C	{"DPYD": {"c.1371C>T": 1, "c.3061G>C": 1}}	\N
6512179	6511090	c.313G>A/c.343A>G	{"DPYD": {"c.313G>A": 1, "c.343A>G": 1}}	\N
6512180	6511090	c.1260T>A/c.2978T>G	{"DPYD": {"c.1260T>A": 1, "c.2978T>G": 1}}	\N
6512181	6511090	c.1403C>A/c.2303C>A	{"DPYD": {"c.1403C>A": 1, "c.2303C>A": 1}}	\N
6512182	6511090	c.929T>C/c.1003G>T (*11)	{"DPYD": {"c.929T>C": 1, "c.1003G>T (*11)": 1}}	\N
6512183	6511090	c.1349C>T/c.2195T>G	{"DPYD": {"c.1349C>T": 1, "c.2195T>G": 1}}	\N
6512184	6511090	c.1358C>G/c.1905C>G	{"DPYD": {"c.1358C>G": 1, "c.1905C>G": 1}}	\N
6512185	6511090	c.775A>G/c.1543G>A	{"DPYD": {"c.775A>G": 1, "c.1543G>A": 1}}	\N
6512186	6511090	c.2194G>A (*6)/Reference	{"DPYD": {"Reference": 1, "c.2194G>A (*6)": 1}}	\N
6512187	6511090	c.1349C>T/c.3067C>A	{"DPYD": {"c.1349C>T": 1, "c.3067C>A": 1}}	\N
6512188	6511090	c.1577C>G/c.3049G>A	{"DPYD": {"c.1577C>G": 1, "c.3049G>A": 1}}	\N
6512189	6511090	c.1543G>A/c.1601G>A (*4)	{"DPYD": {"c.1543G>A": 1, "c.1601G>A (*4)": 1}}	\N
6512190	6511090	c.2194G>A (*6)/c.2623A>C	{"DPYD": {"c.2623A>C": 1, "c.2194G>A (*6)": 1}}	\N
6512191	6511090	c.2657G>A (*9B)/Reference	{"DPYD": {"Reference": 1, "c.2657G>A (*9B)": 1}}	\N
6512192	6511090	c.85T>C (*9A)/c.1003G>T (*11)	{"DPYD": {"c.85T>C (*9A)": 1, "c.1003G>T (*11)": 1}}	\N
6512193	6511090	c.934C>T/c.2915A>G	{"DPYD": {"c.934C>T": 1, "c.2915A>G": 1}}	\N
6512194	6511090	c.525G>A/c.1896T>C	{"DPYD": {"c.525G>A": 1, "c.1896T>C": 1}}	\N
6512195	6511090	c.496A>G/c.1181G>T	{"DPYD": {"c.496A>G": 1, "c.1181G>T": 1}}	\N
6512196	6511090	c.2195T>G/c.2921A>T	{"DPYD": {"c.2195T>G": 1, "c.2921A>T": 1}}	\N
6512197	6511090	c.1358C>G/c.2623A>C	{"DPYD": {"c.1358C>G": 1, "c.2623A>C": 1}}	\N
6512198	6511090	c.46C>G/c.1403C>A	{"DPYD": {"c.46C>G": 1, "c.1403C>A": 1}}	\N
6512199	6511090	c.85T>C (*9A)/c.85T>C (*9A)	{"DPYD": {"c.85T>C (*9A)": 2}}	\N
6512200	6511090	c.1278G>T/c.2161G>A	{"DPYD": {"c.1278G>T": 1, "c.2161G>A": 1}}	\N
6512201	6511090	c.1601G>A (*4)/Reference	{"DPYD": {"Reference": 1, "c.1601G>A (*4)": 1}}	\N
6512202	6511090	c.1627A>G (*5)/c.3061G>C	{"DPYD": {"c.3061G>C": 1, "c.1627A>G (*5)": 1}}	\N
6512203	6511090	c.934C>T/c.2303C>A	{"DPYD": {"c.934C>T": 1, "c.2303C>A": 1}}	\N
6512204	6511090	c.451A>G/c.1371C>T	{"DPYD": {"c.451A>G": 1, "c.1371C>T": 1}}	\N
6512205	6511090	c.1627A>G (*5)/c.1682G>T	{"DPYD": {"c.1682G>T": 1, "c.1627A>G (*5)": 1}}	\N
6512206	6511090	c.1003G>T (*11)/c.2657G>A (*9B)	{"DPYD": {"c.1003G>T (*11)": 1, "c.2657G>A (*9B)": 1}}	\N
6512207	6511090	c.313G>A/c.313G>A	{"DPYD": {"c.313G>A": 2}}	\N
6512208	6511090	c.1543G>A/Reference	{"DPYD": {"Reference": 1, "c.1543G>A": 1}}	\N
6512209	6511090	c.313G>A/c.2921A>T	{"DPYD": {"c.313G>A": 1, "c.2921A>T": 1}}	\N
6512210	6511090	c.313G>A/c.1601G>A (*4)	{"DPYD": {"c.313G>A": 1, "c.1601G>A (*4)": 1}}	\N
6512211	6511090	c.1371C>T/c.1682G>T	{"DPYD": {"c.1371C>T": 1, "c.1682G>T": 1}}	\N
6512212	6511090	c.1371C>T/c.1627A>G (*5)	{"DPYD": {"c.1371C>T": 1, "c.1627A>G (*5)": 1}}	\N
6512213	6511090	c.496A>G/c.1627A>G (*5)	{"DPYD": {"c.496A>G": 1, "c.1627A>G (*5)": 1}}	\N
6512214	6511090	c.1294G>A/c.2336C>A	{"DPYD": {"c.1294G>A": 1, "c.2336C>A": 1}}	\N
6512215	6511090	c.496A>G/c.1615G>A	{"DPYD": {"c.496A>G": 1, "c.1615G>A": 1}}	\N
6512216	6511090	c.2921A>T/c.3061G>C	{"DPYD": {"c.2921A>T": 1, "c.3061G>C": 1}}	\N
6512217	6511090	c.2303C>A/c.2336C>A	{"DPYD": {"c.2303C>A": 1, "c.2336C>A": 1}}	\N
6512218	6511090	c.343A>G/c.2978T>G	{"DPYD": {"c.343A>G": 1, "c.2978T>G": 1}}	\N
6512219	6511090	c.1615G>A/c.1615G>A	{"DPYD": {"c.1615G>A": 2}}	\N
6512220	6511090	c.313G>A/c.2186C>T	{"DPYD": {"c.313G>A": 1, "c.2186C>T": 1}}	\N
6512221	6511090	c.1627A>G (*5)/c.2921A>T	{"DPYD": {"c.2921A>T": 1, "c.1627A>G (*5)": 1}}	\N
6512222	6511090	c.1003G>T (*11)/c.2161G>A	{"DPYD": {"c.2161G>A": 1, "c.1003G>T (*11)": 1}}	\N
6512223	6511090	c.343A>G/c.3067C>A	{"DPYD": {"c.343A>G": 1, "c.3067C>A": 1}}	\N
6512224	6511090	c.934C>T/c.1278G>T	{"DPYD": {"c.934C>T": 1, "c.1278G>T": 1}}	\N
6512225	6511090	c.1615G>A/c.2582A>G	{"DPYD": {"c.1615G>A": 1, "c.2582A>G": 1}}	\N
6512226	6511090	c.343A>G/c.2195T>G	{"DPYD": {"c.343A>G": 1, "c.2195T>G": 1}}	\N
6512227	6511090	c.1682G>T/c.2482G>A	{"DPYD": {"c.1682G>T": 1, "c.2482G>A": 1}}	\N
6512228	6511090	c.62G>A/c.1218G>A	{"DPYD": {"c.62G>A": 1, "c.1218G>A": 1}}	\N
6512229	6511090	c.934C>T/c.3067C>A	{"DPYD": {"c.934C>T": 1, "c.3067C>A": 1}}	\N
6512230	6511090	c.496A>G/c.2582A>G	{"DPYD": {"c.496A>G": 1, "c.2582A>G": 1}}	\N
6512231	6511090	c.1260T>A/c.2195T>G	{"DPYD": {"c.1260T>A": 1, "c.2195T>G": 1}}	\N
6512232	6511090	c.343A>G/c.1349C>T	{"DPYD": {"c.343A>G": 1, "c.1349C>T": 1}}	\N
6512233	6511090	c.1260T>A/c.3067C>A	{"DPYD": {"c.1260T>A": 1, "c.3067C>A": 1}}	\N
6512234	6511090	c.1601G>A (*4)/c.2623A>C	{"DPYD": {"c.2623A>C": 1, "c.1601G>A (*4)": 1}}	\N
6512235	6511090	c.498G>A/c.1519G>A	{"DPYD": {"c.498G>A": 1, "c.1519G>A": 1}}	\N
6512236	6511090	c.1627A>G (*5)/c.2186C>T	{"DPYD": {"c.2186C>T": 1, "c.1627A>G (*5)": 1}}	\N
6512237	6511090	c.934C>T/c.2195T>G	{"DPYD": {"c.934C>T": 1, "c.2195T>G": 1}}	\N
6512238	6511090	c.1181G>T/c.1543G>A	{"DPYD": {"c.1181G>T": 1, "c.1543G>A": 1}}	\N
6512239	6511090	c.313G>A/c.1519G>A	{"DPYD": {"c.313G>A": 1, "c.1519G>A": 1}}	\N
6512240	6511090	c.1003G>T (*11)/c.2194G>A (*6)	{"DPYD": {"c.2194G>A (*6)": 1, "c.1003G>T (*11)": 1}}	\N
6512241	6511090	c.1108A>G/c.2336C>A	{"DPYD": {"c.1108A>G": 1, "c.2336C>A": 1}}	\N
6512242	6511090	c.1905C>G/c.2303C>A	{"DPYD": {"c.1905C>G": 1, "c.2303C>A": 1}}	\N
6512243	6511090	c.525G>A/c.1003G>T (*11)	{"DPYD": {"c.525G>A": 1, "c.1003G>T (*11)": 1}}	\N
6512244	6511090	c.1905C>G/c.2978T>G	{"DPYD": {"c.1905C>G": 1, "c.2978T>G": 1}}	\N
6512245	6511090	c.929T>C/c.1371C>T	{"DPYD": {"c.929T>C": 1, "c.1371C>T": 1}}	\N
6512246	6511090	c.451A>G/c.2977C>T	{"DPYD": {"c.451A>G": 1, "c.2977C>T": 1}}	\N
6512247	6511090	c.1349C>T/c.2303C>A	{"DPYD": {"c.1349C>T": 1, "c.2303C>A": 1}}	\N
6512248	6511090	c.1906A>C/c.2656C>T	{"DPYD": {"c.1906A>C": 1, "c.2656C>T": 1}}	\N
6512249	6511090	c.1615G>A/Reference	{"DPYD": {"Reference": 1, "c.1615G>A": 1}}	\N
6512250	6511090	c.1180C>T/c.1577C>G	{"DPYD": {"c.1180C>T": 1, "c.1577C>G": 1}}	\N
6512251	6511090	c.343A>G/c.2303C>A	{"DPYD": {"c.343A>G": 1, "c.2303C>A": 1}}	\N
6512252	6511090	c.313G>A/Reference	{"DPYD": {"c.313G>A": 1, "Reference": 1}}	\N
6512253	6511090	c.1108A>G/c.1990G>T	{"DPYD": {"c.1108A>G": 1, "c.1990G>T": 1}}	\N
6512254	6511090	c.451A>G/c.3061G>C	{"DPYD": {"c.451A>G": 1, "c.3061G>C": 1}}	\N
6512255	6511090	c.1358C>G/c.2915A>G	{"DPYD": {"c.1358C>G": 1, "c.2915A>G": 1}}	\N
6512256	6511090	c.2303C>A/c.2977C>T	{"DPYD": {"c.2303C>A": 1, "c.2977C>T": 1}}	\N
6512257	6511090	c.1896T>C/c.2656C>T	{"DPYD": {"c.1896T>C": 1, "c.2656C>T": 1}}	\N
6512258	6511090	c.1181G>T/c.2656C>T	{"DPYD": {"c.1181G>T": 1, "c.2656C>T": 1}}	\N
6512259	6511090	c.1108A>G/c.1358C>G	{"DPYD": {"c.1108A>G": 1, "c.1358C>G": 1}}	\N
6512260	6511090	c.1577C>G/c.2482G>A	{"DPYD": {"c.1577C>G": 1, "c.2482G>A": 1}}	\N
6512261	6511090	c.496A>G/c.1260T>A	{"DPYD": {"c.496A>G": 1, "c.1260T>A": 1}}	\N
6512262	6511090	c.1181G>T/c.1796T>C	{"DPYD": {"c.1181G>T": 1, "c.1796T>C": 1}}	\N
6512263	6511090	c.85T>C (*9A)/c.1896T>C	{"DPYD": {"c.1896T>C": 1, "c.85T>C (*9A)": 1}}	\N
6512264	6511090	c.525G>A/c.1990G>T	{"DPYD": {"c.525G>A": 1, "c.1990G>T": 1}}	\N
6512265	6511090	c.85T>C (*9A)/c.2977C>T	{"DPYD": {"c.2977C>T": 1, "c.85T>C (*9A)": 1}}	\N
6512266	6511090	c.1519G>A/c.2194G>A (*6)	{"DPYD": {"c.1519G>A": 1, "c.2194G>A (*6)": 1}}	\N
6512267	6511090	c.498G>A/c.2921A>T	{"DPYD": {"c.498G>A": 1, "c.2921A>T": 1}}	\N
6512268	6511090	c.498G>A/c.2186C>T	{"DPYD": {"c.498G>A": 1, "c.2186C>T": 1}}	\N
6512269	6511090	c.1601G>A (*4)/c.1601G>A (*4)	{"DPYD": {"c.1601G>A (*4)": 2}}	\N
6512270	6511090	c.46C>G/c.2482G>A	{"DPYD": {"c.46C>G": 1, "c.2482G>A": 1}}	\N
6512271	6511090	c.929T>C/c.1990G>T	{"DPYD": {"c.929T>C": 1, "c.1990G>T": 1}}	\N
6512272	6511090	c.498G>A/c.1294G>A	{"DPYD": {"c.498G>A": 1, "c.1294G>A": 1}}	\N
6512273	6511090	c.2336C>A/c.2978T>G	{"DPYD": {"c.2336C>A": 1, "c.2978T>G": 1}}	\N
6512274	6511090	c.2921A>T/c.3067C>A	{"DPYD": {"c.2921A>T": 1, "c.3067C>A": 1}}	\N
6512275	6511090	c.343A>G/Reference	{"DPYD": {"c.343A>G": 1, "Reference": 1}}	\N
6512276	6511090	c.1601G>A (*4)/c.2582A>G	{"DPYD": {"c.2582A>G": 1, "c.1601G>A (*4)": 1}}	\N
6512277	6511090	c.1108A>G/c.2186C>T	{"DPYD": {"c.1108A>G": 1, "c.2186C>T": 1}}	\N
6512278	6511090	c.498G>A/c.1601G>A (*4)	{"DPYD": {"c.498G>A": 1, "c.1601G>A (*4)": 1}}	\N
6512279	6511090	c.1260T>A/c.1543G>A	{"DPYD": {"c.1260T>A": 1, "c.1543G>A": 1}}	\N
6512280	6511090	c.1218G>A/c.1896T>C	{"DPYD": {"c.1218G>A": 1, "c.1896T>C": 1}}	\N
6512281	6511090	c.1627A>G (*5)/c.2336C>A	{"DPYD": {"c.2336C>A": 1, "c.1627A>G (*5)": 1}}	\N
6512282	6511090	c.46C>G/c.2978T>G	{"DPYD": {"c.46C>G": 1, "c.2978T>G": 1}}	\N
6512283	6511090	c.46C>G/c.2336C>A	{"DPYD": {"c.46C>G": 1, "c.2336C>A": 1}}	\N
6512284	6511090	c.967G>A/c.1294G>A	{"DPYD": {"c.967G>A": 1, "c.1294G>A": 1}}	\N
6512285	6511090	c.2161G>A/c.2656C>T	{"DPYD": {"c.2161G>A": 1, "c.2656C>T": 1}}	\N
6512286	6511090	c.525G>A/c.1577C>G	{"DPYD": {"c.525G>A": 1, "c.1577C>G": 1}}	\N
6512287	6511090	c.1905C>G/c.2195T>G	{"DPYD": {"c.1905C>G": 1, "c.2195T>G": 1}}	\N
6512288	6511090	c.2657G>A (*9B)/c.2978T>G	{"DPYD": {"c.2978T>G": 1, "c.2657G>A (*9B)": 1}}	\N
6512289	6511090	c.1260T>A/c.1896T>C	{"DPYD": {"c.1260T>A": 1, "c.1896T>C": 1}}	\N
6512290	6511090	c.1905C>G/c.2657G>A (*9B)	{"DPYD": {"c.1905C>G": 1, "c.2657G>A (*9B)": 1}}	\N
6512291	6511090	c.934C>T/c.2336C>A	{"DPYD": {"c.934C>T": 1, "c.2336C>A": 1}}	\N
6512292	6511090	c.1181G>T/c.1278G>T	{"DPYD": {"c.1181G>T": 1, "c.1278G>T": 1}}	\N
6512293	6511090	c.451A>G/c.1181G>T	{"DPYD": {"c.451A>G": 1, "c.1181G>T": 1}}	\N
6512294	6511090	c.62G>A/c.929T>C	{"DPYD": {"c.62G>A": 1, "c.929T>C": 1}}	\N
6512295	6511090	c.1896T>C/c.3061G>C	{"DPYD": {"c.1896T>C": 1, "c.3061G>C": 1}}	\N
6512296	6511090	c.1682G>T/c.1682G>T	{"DPYD": {"c.1682G>T": 2}}	\N
6512297	6511090	c.1796T>C/c.2186C>T	{"DPYD": {"c.1796T>C": 1, "c.2186C>T": 1}}	\N
6512298	6511090	c.1180C>T/c.3061G>C	{"DPYD": {"c.1180C>T": 1, "c.3061G>C": 1}}	\N
6512299	6511090	c.313G>A/c.3067C>A	{"DPYD": {"c.313G>A": 1, "c.3067C>A": 1}}	\N
6512300	6511090	c.1906A>C/c.2977C>T	{"DPYD": {"c.1906A>C": 1, "c.2977C>T": 1}}	\N
6512301	6511090	c.1577C>G/c.2303C>A	{"DPYD": {"c.1577C>G": 1, "c.2303C>A": 1}}	\N
6512302	6511090	c.525G>A/c.1796T>C	{"DPYD": {"c.525G>A": 1, "c.1796T>C": 1}}	\N
6512303	6511090	c.1003G>T (*11)/c.1180C>T	{"DPYD": {"c.1180C>T": 1, "c.1003G>T (*11)": 1}}	\N
6512304	6511090	c.929T>C/c.934C>T	{"DPYD": {"c.929T>C": 1, "c.934C>T": 1}}	\N
6512305	6511090	c.85T>C (*9A)/c.1294G>A	{"DPYD": {"c.1294G>A": 1, "c.85T>C (*9A)": 1}}	\N
6512306	6511090	c.1278G>T/c.2303C>A	{"DPYD": {"c.1278G>T": 1, "c.2303C>A": 1}}	\N
6512307	6511090	c.62G>A/c.1180C>T	{"DPYD": {"c.62G>A": 1, "c.1180C>T": 1}}	\N
6512308	6511090	c.1896T>C/c.1896T>C	{"DPYD": {"c.1896T>C": 2}}	\N
6512309	6511090	c.525G>A/c.1601G>A (*4)	{"DPYD": {"c.525G>A": 1, "c.1601G>A (*4)": 1}}	\N
6512310	6511090	c.496A>G/c.2161G>A	{"DPYD": {"c.496A>G": 1, "c.2161G>A": 1}}	\N
6512311	6511090	c.1349C>T/c.3049G>A	{"DPYD": {"c.1349C>T": 1, "c.3049G>A": 1}}	\N
6512312	6511090	c.1260T>A/c.1682G>T	{"DPYD": {"c.1260T>A": 1, "c.1682G>T": 1}}	\N
6512313	6511090	c.2186C>T/c.2978T>G	{"DPYD": {"c.2186C>T": 1, "c.2978T>G": 1}}	\N
6512314	6511090	c.46C>G/c.2186C>T	{"DPYD": {"c.46C>G": 1, "c.2186C>T": 1}}	\N
6512315	6511090	c.934C>T/c.2186C>T	{"DPYD": {"c.934C>T": 1, "c.2186C>T": 1}}	\N
6512316	6511090	c.313G>A/c.2656C>T	{"DPYD": {"c.313G>A": 1, "c.2656C>T": 1}}	\N
6512317	6511090	c.498G>A/c.1358C>G	{"DPYD": {"c.498G>A": 1, "c.1358C>G": 1}}	\N
6512318	6511090	c.451A>G/c.1615G>A	{"DPYD": {"c.451A>G": 1, "c.1615G>A": 1}}	\N
6512319	6511090	c.2194G>A (*6)/c.2977C>T	{"DPYD": {"c.2977C>T": 1, "c.2194G>A (*6)": 1}}	\N
6512320	6511090	c.1278G>T/c.1990G>T	{"DPYD": {"c.1278G>T": 1, "c.1990G>T": 1}}	\N
6512321	6511090	c.1260T>A/c.1601G>A (*4)	{"DPYD": {"c.1260T>A": 1, "c.1601G>A (*4)": 1}}	\N
6512322	6511090	c.313G>A/c.2303C>A	{"DPYD": {"c.313G>A": 1, "c.2303C>A": 1}}	\N
6512323	6511090	c.1403C>A/c.2482G>A	{"DPYD": {"c.1403C>A": 1, "c.2482G>A": 1}}	\N
6512324	6511090	c.1577C>G/c.3067C>A	{"DPYD": {"c.1577C>G": 1, "c.3067C>A": 1}}	\N
6512325	6511090	c.1181G>T/Reference	{"DPYD": {"Reference": 1, "c.1181G>T": 1}}	\N
6512326	6511090	c.1896T>C/c.2623A>C	{"DPYD": {"c.1896T>C": 1, "c.2623A>C": 1}}	\N
6512327	6511090	c.1682G>T/c.1896T>C	{"DPYD": {"c.1682G>T": 1, "c.1896T>C": 1}}	\N
6512328	6511090	c.1108A>G/c.1180C>T	{"DPYD": {"c.1108A>G": 1, "c.1180C>T": 1}}	\N
6512329	6511090	c.343A>G/c.1358C>G	{"DPYD": {"c.343A>G": 1, "c.1358C>G": 1}}	\N
6512330	6511090	c.1218G>A/c.3061G>C	{"DPYD": {"c.1218G>A": 1, "c.3061G>C": 1}}	\N
6512331	6511090	c.343A>G/c.1278G>T	{"DPYD": {"c.343A>G": 1, "c.1278G>T": 1}}	\N
6512332	6511090	c.1349C>T/c.2921A>T	{"DPYD": {"c.1349C>T": 1, "c.2921A>T": 1}}	\N
6512333	6511090	c.2482G>A/c.2977C>T	{"DPYD": {"c.2482G>A": 1, "c.2977C>T": 1}}	\N
6512334	6511090	c.1108A>G/c.1627A>G (*5)	{"DPYD": {"c.1108A>G": 1, "c.1627A>G (*5)": 1}}	\N
6512335	6511090	c.496A>G/c.934C>T	{"DPYD": {"c.496A>G": 1, "c.934C>T": 1}}	\N
6512336	6511090	c.775A>G/c.3067C>A	{"DPYD": {"c.775A>G": 1, "c.3067C>A": 1}}	\N
6512337	6511090	c.46C>G/c.1905C>G	{"DPYD": {"c.46C>G": 1, "c.1905C>G": 1}}	\N
6512338	6511090	c.1577C>G/c.2921A>T	{"DPYD": {"c.1577C>G": 1, "c.2921A>T": 1}}	\N
6512339	6511090	c.1278G>T/c.3067C>A	{"DPYD": {"c.1278G>T": 1, "c.3067C>A": 1}}	\N
6512340	6511090	c.1682G>T/c.2623A>C	{"DPYD": {"c.1682G>T": 1, "c.2623A>C": 1}}	\N
6512341	6511090	c.2921A>T/c.2921A>T	{"DPYD": {"c.2921A>T": 2}}	\N
6512342	6511090	c.929T>C/c.2161G>A	{"DPYD": {"c.929T>C": 1, "c.2161G>A": 1}}	\N
6512343	6511090	c.498G>A/c.1371C>T	{"DPYD": {"c.498G>A": 1, "c.1371C>T": 1}}	\N
6512344	6511090	c.1905C>G/c.2482G>A	{"DPYD": {"c.1905C>G": 1, "c.2482G>A": 1}}	\N
6512345	6511090	c.1403C>A/c.1601G>A (*4)	{"DPYD": {"c.1403C>A": 1, "c.1601G>A (*4)": 1}}	\N
6512346	6511090	c.1371C>T/c.2921A>T	{"DPYD": {"c.1371C>T": 1, "c.2921A>T": 1}}	\N
6512347	6511090	c.498G>A/c.1796T>C	{"DPYD": {"c.498G>A": 1, "c.1796T>C": 1}}	\N
6512348	6511090	c.1180C>T/c.1896T>C	{"DPYD": {"c.1180C>T": 1, "c.1896T>C": 1}}	\N
6512349	6511090	c.1543G>A/c.2915A>G	{"DPYD": {"c.1543G>A": 1, "c.2915A>G": 1}}	\N
6512350	6511090	c.1990G>T/c.2915A>G	{"DPYD": {"c.1990G>T": 1, "c.2915A>G": 1}}	\N
6512351	6511090	c.496A>G/c.525G>A	{"DPYD": {"c.496A>G": 1, "c.525G>A": 1}}	\N
6512352	6511090	c.496A>G/c.3061G>C	{"DPYD": {"c.496A>G": 1, "c.3061G>C": 1}}	\N
6512353	6511090	c.1601G>A (*4)/c.2161G>A	{"DPYD": {"c.2161G>A": 1, "c.1601G>A (*4)": 1}}	\N
6512354	6511090	c.2656C>T/c.3067C>A	{"DPYD": {"c.2656C>T": 1, "c.3067C>A": 1}}	\N
6512355	6511090	c.1003G>T (*11)/c.2978T>G	{"DPYD": {"c.2978T>G": 1, "c.1003G>T (*11)": 1}}	\N
6512356	6511090	c.1601G>A (*4)/c.2482G>A	{"DPYD": {"c.2482G>A": 1, "c.1601G>A (*4)": 1}}	\N
6512357	6511090	c.2186C>T/c.2336C>A	{"DPYD": {"c.2186C>T": 1, "c.2336C>A": 1}}	\N
6512358	6511090	c.1260T>A/c.3061G>C	{"DPYD": {"c.1260T>A": 1, "c.3061G>C": 1}}	\N
6512359	6511090	c.1403C>A/c.1543G>A	{"DPYD": {"c.1403C>A": 1, "c.1543G>A": 1}}	\N
6512360	6511090	c.1403C>A/c.2657G>A (*9B)	{"DPYD": {"c.1403C>A": 1, "c.2657G>A (*9B)": 1}}	\N
6512361	6511090	c.1403C>A/c.2195T>G	{"DPYD": {"c.1403C>A": 1, "c.2195T>G": 1}}	\N
6512362	6511090	c.1218G>A/c.1905C>G	{"DPYD": {"c.1218G>A": 1, "c.1905C>G": 1}}	\N
6512363	6511090	c.46C>G/c.85T>C (*9A)	{"DPYD": {"c.46C>G": 1, "c.85T>C (*9A)": 1}}	\N
6512364	6511090	c.1682G>T/c.1905C>G	{"DPYD": {"c.1682G>T": 1, "c.1905C>G": 1}}	\N
6512365	6511090	c.1627A>G (*5)/c.1896T>C	{"DPYD": {"c.1896T>C": 1, "c.1627A>G (*5)": 1}}	\N
6512366	6511090	c.1108A>G/c.2915A>G	{"DPYD": {"c.1108A>G": 1, "c.2915A>G": 1}}	\N
6512367	6511090	c.496A>G/c.1896T>C	{"DPYD": {"c.496A>G": 1, "c.1896T>C": 1}}	\N
6512368	6511090	c.46C>G/c.2623A>C	{"DPYD": {"c.46C>G": 1, "c.2623A>C": 1}}	\N
6512369	6511090	c.1180C>T/c.1682G>T	{"DPYD": {"c.1180C>T": 1, "c.1682G>T": 1}}	\N
6512370	6511090	c.343A>G/c.1577C>G	{"DPYD": {"c.343A>G": 1, "c.1577C>G": 1}}	\N
6512371	6511090	c.343A>G/c.2161G>A	{"DPYD": {"c.343A>G": 1, "c.2161G>A": 1}}	\N
6512372	6511090	c.1682G>T/c.3061G>C	{"DPYD": {"c.1682G>T": 1, "c.3061G>C": 1}}	\N
6512373	6511090	c.1403C>A/c.1682G>T	{"DPYD": {"c.1403C>A": 1, "c.1682G>T": 1}}	\N
6512374	6511090	c.85T>C (*9A)/c.1906A>C	{"DPYD": {"c.1906A>C": 1, "c.85T>C (*9A)": 1}}	\N
6512375	6511090	c.313G>A/c.2977C>T	{"DPYD": {"c.313G>A": 1, "c.2977C>T": 1}}	\N
6512376	6511090	c.1003G>T (*11)/c.1349C>T	{"DPYD": {"c.1349C>T": 1, "c.1003G>T (*11)": 1}}	\N
6512377	6511090	c.1905C>G/c.2582A>G	{"DPYD": {"c.1905C>G": 1, "c.2582A>G": 1}}	\N
6512378	6511090	c.2195T>G/c.2978T>G	{"DPYD": {"c.2195T>G": 1, "c.2978T>G": 1}}	\N
6512379	6511090	c.498G>A/c.1682G>T	{"DPYD": {"c.498G>A": 1, "c.1682G>T": 1}}	\N
6512380	6511090	c.1108A>G/c.2978T>G	{"DPYD": {"c.1108A>G": 1, "c.2978T>G": 1}}	\N
6512381	6511090	c.1180C>T/c.1796T>C	{"DPYD": {"c.1180C>T": 1, "c.1796T>C": 1}}	\N
6512382	6511090	c.1260T>A/c.1905C>G	{"DPYD": {"c.1260T>A": 1, "c.1905C>G": 1}}	\N
6512383	6511090	c.525G>A/c.3061G>C	{"DPYD": {"c.525G>A": 1, "c.3061G>C": 1}}	\N
6512384	6511090	c.934C>T/c.1905C>G	{"DPYD": {"c.934C>T": 1, "c.1905C>G": 1}}	\N
6512385	6511090	c.1615G>A/c.3049G>A	{"DPYD": {"c.1615G>A": 1, "c.3049G>A": 1}}	\N
6512386	6511090	c.1218G>A/c.2623A>C	{"DPYD": {"c.1218G>A": 1, "c.2623A>C": 1}}	\N
6512387	6511090	c.934C>T/c.2623A>C	{"DPYD": {"c.934C>T": 1, "c.2623A>C": 1}}	\N
6512388	6511090	c.1180C>T/c.1601G>A (*4)	{"DPYD": {"c.1180C>T": 1, "c.1601G>A (*4)": 1}}	\N
6512389	6511090	c.1260T>A/c.2623A>C	{"DPYD": {"c.1260T>A": 1, "c.2623A>C": 1}}	\N
6512390	6511090	c.46C>G/c.1896T>C	{"DPYD": {"c.46C>G": 1, "c.1896T>C": 1}}	\N
6512391	6511090	c.343A>G/c.1796T>C	{"DPYD": {"c.343A>G": 1, "c.1796T>C": 1}}	\N
6512392	6511090	c.929T>C/c.1181G>T	{"DPYD": {"c.929T>C": 1, "c.1181G>T": 1}}	\N
6512393	6511090	c.934C>T/c.1543G>A	{"DPYD": {"c.934C>T": 1, "c.1543G>A": 1}}	\N
6512394	6511090	c.2657G>A (*9B)/c.2915A>G	{"DPYD": {"c.2915A>G": 1, "c.2657G>A (*9B)": 1}}	\N
6512395	6511090	c.2978T>G/c.3049G>A	{"DPYD": {"c.2978T>G": 1, "c.3049G>A": 1}}	\N
6512396	6511090	c.1108A>G/c.1905C>G	{"DPYD": {"c.1108A>G": 1, "c.1905C>G": 1}}	\N
6512397	6511090	c.1218G>A/c.2482G>A	{"DPYD": {"c.1218G>A": 1, "c.2482G>A": 1}}	\N
6512398	6511090	c.1519G>A/c.3049G>A	{"DPYD": {"c.1519G>A": 1, "c.3049G>A": 1}}	\N
6512399	6511090	c.451A>G/c.967G>A	{"DPYD": {"c.451A>G": 1, "c.967G>A": 1}}	\N
6512400	6511090	c.2336C>A/Reference	{"DPYD": {"Reference": 1, "c.2336C>A": 1}}	\N
6512401	6511090	c.2656C>T/c.2977C>T	{"DPYD": {"c.2656C>T": 1, "c.2977C>T": 1}}	\N
6512402	6511090	c.1990G>T/c.3049G>A	{"DPYD": {"c.1990G>T": 1, "c.3049G>A": 1}}	\N
6512403	6511090	c.2186C>T/c.2623A>C	{"DPYD": {"c.2186C>T": 1, "c.2623A>C": 1}}	\N
6512404	6511090	c.1601G>A (*4)/c.3061G>C	{"DPYD": {"c.3061G>C": 1, "c.1601G>A (*4)": 1}}	\N
6512405	6511090	c.525G>A/c.2623A>C	{"DPYD": {"c.525G>A": 1, "c.2623A>C": 1}}	\N
6512406	6511090	c.451A>G/c.1218G>A	{"DPYD": {"c.451A>G": 1, "c.1218G>A": 1}}	\N
6512407	6511090	c.2482G>A/c.2582A>G	{"DPYD": {"c.2482G>A": 1, "c.2582A>G": 1}}	\N
6512408	6511090	c.1403C>A/c.1905C>G	{"DPYD": {"c.1403C>A": 1, "c.1905C>G": 1}}	\N
6512409	6511090	c.1403C>A/c.2623A>C	{"DPYD": {"c.1403C>A": 1, "c.2623A>C": 1}}	\N
6512410	6511090	c.1682G>T/c.2195T>G	{"DPYD": {"c.1682G>T": 1, "c.2195T>G": 1}}	\N
6512411	6511090	c.1682G>T/c.2657G>A (*9B)	{"DPYD": {"c.1682G>T": 1, "c.2657G>A (*9B)": 1}}	\N
6512412	6511090	c.525G>A/c.1905C>G	{"DPYD": {"c.525G>A": 1, "c.1905C>G": 1}}	\N
6512413	6511090	c.46C>G/c.2915A>G	{"DPYD": {"c.46C>G": 1, "c.2915A>G": 1}}	\N
6512414	6511090	c.1543G>A/c.3049G>A	{"DPYD": {"c.1543G>A": 1, "c.3049G>A": 1}}	\N
6512415	6511090	c.929T>C/c.1615G>A	{"DPYD": {"c.929T>C": 1, "c.1615G>A": 1}}	\N
6512416	6511090	c.1896T>C/c.2336C>A	{"DPYD": {"c.1896T>C": 1, "c.2336C>A": 1}}	\N
6512417	6511090	c.62G>A/c.1003G>T (*11)	{"DPYD": {"c.62G>A": 1, "c.1003G>T (*11)": 1}}	\N
6512418	6511090	c.496A>G/c.1278G>T	{"DPYD": {"c.496A>G": 1, "c.1278G>T": 1}}	\N
6512419	6511090	c.2656C>T/c.2656C>T	{"DPYD": {"c.2656C>T": 2}}	\N
6512420	6511090	c.2195T>G/c.2915A>G	{"DPYD": {"c.2195T>G": 1, "c.2915A>G": 1}}	\N
6512421	6511090	c.2623A>C/c.2656C>T	{"DPYD": {"c.2623A>C": 1, "c.2656C>T": 1}}	\N
6512422	6511090	c.967G>A/c.2303C>A	{"DPYD": {"c.967G>A": 1, "c.2303C>A": 1}}	\N
6512423	6511090	c.3067C>A/Reference	{"DPYD": {"Reference": 1, "c.3067C>A": 1}}	\N
6512424	6511090	c.2186C>T/c.2915A>G	{"DPYD": {"c.2186C>T": 1, "c.2915A>G": 1}}	\N
6512425	6511090	c.46C>G/c.451A>G	{"DPYD": {"c.46C>G": 1, "c.451A>G": 1}}	\N
6512426	6511090	c.2303C>A/c.2656C>T	{"DPYD": {"c.2303C>A": 1, "c.2656C>T": 1}}	\N
6512427	6511090	c.451A>G/c.2161G>A	{"DPYD": {"c.451A>G": 1, "c.2161G>A": 1}}	\N
6512428	6511090	c.451A>G/c.2656C>T	{"DPYD": {"c.451A>G": 1, "c.2656C>T": 1}}	\N
6512429	6511090	c.1260T>A/c.2582A>G	{"DPYD": {"c.1260T>A": 1, "c.2582A>G": 1}}	\N
6512430	6511090	c.967G>A/c.3067C>A	{"DPYD": {"c.967G>A": 1, "c.3067C>A": 1}}	\N
6512431	6511090	c.1906A>C/c.3049G>A	{"DPYD": {"c.1906A>C": 1, "c.3049G>A": 1}}	\N
6512432	6511090	c.1218G>A/c.2186C>T	{"DPYD": {"c.1218G>A": 1, "c.2186C>T": 1}}	\N
6512433	6511090	c.775A>G/c.2303C>A	{"DPYD": {"c.775A>G": 1, "c.2303C>A": 1}}	\N
6512434	6511090	c.498G>A/c.1905C>G	{"DPYD": {"c.498G>A": 1, "c.1905C>G": 1}}	\N
6512435	6511090	c.1278G>T/c.2656C>T	{"DPYD": {"c.1278G>T": 1, "c.2656C>T": 1}}	\N
6512436	6511090	c.46C>G/c.525G>A	{"DPYD": {"c.46C>G": 1, "c.525G>A": 1}}	\N
6512437	6511090	c.313G>A/c.967G>A	{"DPYD": {"c.313G>A": 1, "c.967G>A": 1}}	\N
6512438	6511090	c.498G>A/c.1003G>T (*11)	{"DPYD": {"c.498G>A": 1, "c.1003G>T (*11)": 1}}	\N
6512439	6511090	c.934C>T/c.1601G>A (*4)	{"DPYD": {"c.934C>T": 1, "c.1601G>A (*4)": 1}}	\N
6512440	6511090	c.934C>T/c.1627A>G (*5)	{"DPYD": {"c.934C>T": 1, "c.1627A>G (*5)": 1}}	\N
6512441	6511090	c.1260T>A/c.2186C>T	{"DPYD": {"c.1260T>A": 1, "c.2186C>T": 1}}	\N
6512442	6511090	c.1990G>T/c.2194G>A (*6)	{"DPYD": {"c.1990G>T": 1, "c.2194G>A (*6)": 1}}	\N
6512443	6511090	c.934C>T/c.1682G>T	{"DPYD": {"c.934C>T": 1, "c.1682G>T": 1}}	\N
6512444	6511090	c.1181G>T/c.1358C>G	{"DPYD": {"c.1181G>T": 1, "c.1358C>G": 1}}	\N
6512445	6511090	c.1906A>C/c.1906A>C	{"DPYD": {"c.1906A>C": 2}}	\N
6512446	6511090	c.525G>A/c.2582A>G	{"DPYD": {"c.525G>A": 1, "c.2582A>G": 1}}	\N
6512447	6511090	c.1218G>A/c.1601G>A (*4)	{"DPYD": {"c.1218G>A": 1, "c.1601G>A (*4)": 1}}	\N
6512448	6511090	c.1796T>C/c.2336C>A	{"DPYD": {"c.1796T>C": 1, "c.2336C>A": 1}}	\N
6512449	6511090	c.1896T>C/c.2978T>G	{"DPYD": {"c.1896T>C": 1, "c.2978T>G": 1}}	\N
6512450	6511090	c.1905C>G/c.2623A>C	{"DPYD": {"c.1905C>G": 1, "c.2623A>C": 1}}	\N
6512451	6511090	c.1003G>T (*11)/c.1294G>A	{"DPYD": {"c.1294G>A": 1, "c.1003G>T (*11)": 1}}	\N
6512452	6511090	c.498G>A/c.1577C>G	{"DPYD": {"c.498G>A": 1, "c.1577C>G": 1}}	\N
6512453	6511090	c.1905C>G/c.2656C>T	{"DPYD": {"c.1905C>G": 1, "c.2656C>T": 1}}	\N
6512454	6511090	c.929T>C/c.1543G>A	{"DPYD": {"c.929T>C": 1, "c.1543G>A": 1}}	\N
6512455	6511090	c.2194G>A (*6)/c.3067C>A	{"DPYD": {"c.3067C>A": 1, "c.2194G>A (*6)": 1}}	\N
6512456	6511090	c.343A>G/c.1181G>T	{"DPYD": {"c.343A>G": 1, "c.1181G>T": 1}}	\N
6512457	6511090	c.1796T>C/c.2978T>G	{"DPYD": {"c.1796T>C": 1, "c.2978T>G": 1}}	\N
6512458	6511090	c.2482G>A/c.2482G>A	{"DPYD": {"c.2482G>A": 2}}	\N
6512459	6511090	c.1218G>A/c.1682G>T	{"DPYD": {"c.1218G>A": 1, "c.1682G>T": 1}}	\N
6512460	6511090	c.1218G>A/c.2582A>G	{"DPYD": {"c.1218G>A": 1, "c.2582A>G": 1}}	\N
6512461	6511090	c.1358C>G/c.2978T>G	{"DPYD": {"c.1358C>G": 1, "c.2978T>G": 1}}	\N
6512462	6511090	c.2482G>A/c.2656C>T	{"DPYD": {"c.2482G>A": 1, "c.2656C>T": 1}}	\N
6512463	6511090	c.929T>C/c.2482G>A	{"DPYD": {"c.929T>C": 1, "c.2482G>A": 1}}	\N
6512464	6511090	c.2977C>T/c.2977C>T	{"DPYD": {"c.2977C>T": 2}}	\N
6512465	6511090	c.498G>A/c.2623A>C	{"DPYD": {"c.498G>A": 1, "c.2623A>C": 1}}	\N
6512466	6511090	c.313G>A/c.1990G>T	{"DPYD": {"c.313G>A": 1, "c.1990G>T": 1}}	\N
6512467	6511090	c.1906A>C/c.2194G>A (*6)	{"DPYD": {"c.1906A>C": 1, "c.2194G>A (*6)": 1}}	\N
6512468	6511090	c.525G>A/c.1682G>T	{"DPYD": {"c.525G>A": 1, "c.1682G>T": 1}}	\N
6512469	6511090	c.1796T>C/c.1896T>C	{"DPYD": {"c.1796T>C": 1, "c.1896T>C": 1}}	\N
6512470	6511090	c.929T>C/Reference	{"DPYD": {"c.929T>C": 1, "Reference": 1}}	\N
6512471	6511090	c.1294G>A/c.1294G>A	{"DPYD": {"c.1294G>A": 2}}	\N
6512472	6511090	c.496A>G/c.2336C>A	{"DPYD": {"c.496A>G": 1, "c.2336C>A": 1}}	\N
6512473	6511090	c.1543G>A/c.2194G>A (*6)	{"DPYD": {"c.1543G>A": 1, "c.2194G>A (*6)": 1}}	\N
6512474	6511090	c.1003G>T (*11)/c.1108A>G	{"DPYD": {"c.1108A>G": 1, "c.1003G>T (*11)": 1}}	\N
6512475	6511090	c.1601G>A (*4)/c.1896T>C	{"DPYD": {"c.1896T>C": 1, "c.1601G>A (*4)": 1}}	\N
6512476	6511090	c.1601G>A (*4)/c.2977C>T	{"DPYD": {"c.2977C>T": 1, "c.1601G>A (*4)": 1}}	\N
6512477	6511090	c.1003G>T (*11)/Reference	{"DPYD": {"Reference": 1, "c.1003G>T (*11)": 1}}	\N
6512478	6511090	c.1108A>G/c.1260T>A	{"DPYD": {"c.1108A>G": 1, "c.1260T>A": 1}}	\N
6512479	6511090	c.1896T>C/c.2195T>G	{"DPYD": {"c.1896T>C": 1, "c.2195T>G": 1}}	\N
6512480	6511090	c.1896T>C/c.2657G>A (*9B)	{"DPYD": {"c.1896T>C": 1, "c.2657G>A (*9B)": 1}}	\N
6512481	6511090	c.1682G>T/c.2336C>A	{"DPYD": {"c.1682G>T": 1, "c.2336C>A": 1}}	\N
6512482	6511090	c.451A>G/c.525G>A	{"DPYD": {"c.451A>G": 1, "c.525G>A": 1}}	\N
6512483	6511090	c.1906A>C/c.1990G>T	{"DPYD": {"c.1906A>C": 1, "c.1990G>T": 1}}	\N
6512484	6511090	c.2194G>A (*6)/c.2303C>A	{"DPYD": {"c.2303C>A": 1, "c.2194G>A (*6)": 1}}	\N
6512485	6511090	c.1260T>A/c.2482G>A	{"DPYD": {"c.1260T>A": 1, "c.2482G>A": 1}}	\N
6512486	6511090	c.967G>A/c.2921A>T	{"DPYD": {"c.967G>A": 1, "c.2921A>T": 1}}	\N
6512487	6511090	c.85T>C (*9A)/c.929T>C	{"DPYD": {"c.929T>C": 1, "c.85T>C (*9A)": 1}}	\N
6512488	6511090	c.313G>A/c.1906A>C	{"DPYD": {"c.313G>A": 1, "c.1906A>C": 1}}	\N
6512489	6511090	c.343A>G/c.1615G>A	{"DPYD": {"c.343A>G": 1, "c.1615G>A": 1}}	\N
6512490	6511090	c.934C>T/c.2482G>A	{"DPYD": {"c.934C>T": 1, "c.2482G>A": 1}}	\N
6512491	6511090	c.1218G>A/c.1543G>A	{"DPYD": {"c.1218G>A": 1, "c.1543G>A": 1}}	\N
6512492	6511090	c.1180C>T/c.2582A>G	{"DPYD": {"c.1180C>T": 1, "c.2582A>G": 1}}	\N
6512493	6511090	c.1906A>C/c.2657G>A (*9B)	{"DPYD": {"c.1906A>C": 1, "c.2657G>A (*9B)": 1}}	\N
6512494	6511090	c.1906A>C/c.2195T>G	{"DPYD": {"c.1906A>C": 1, "c.2195T>G": 1}}	\N
6512495	6511090	c.1371C>T/c.2194G>A (*6)	{"DPYD": {"c.1371C>T": 1, "c.2194G>A (*6)": 1}}	\N
6512496	6511090	c.2977C>T/c.3049G>A	{"DPYD": {"c.2977C>T": 1, "c.3049G>A": 1}}	\N
6512497	6511090	c.1349C>T/c.1403C>A	{"DPYD": {"c.1349C>T": 1, "c.1403C>A": 1}}	\N
6512498	6511090	c.1108A>G/c.1108A>G	{"DPYD": {"c.1108A>G": 2}}	\N
6512499	6511090	c.1278G>T/c.1519G>A	{"DPYD": {"c.1278G>T": 1, "c.1519G>A": 1}}	\N
6512500	6511090	c.934C>T/c.1260T>A	{"DPYD": {"c.934C>T": 1, "c.1260T>A": 1}}	\N
6512501	6511090	c.1615G>A/c.2194G>A (*6)	{"DPYD": {"c.1615G>A": 1, "c.2194G>A (*6)": 1}}	\N
6512502	6511090	c.1181G>T/c.1371C>T	{"DPYD": {"c.1181G>T": 1, "c.1371C>T": 1}}	\N
6512503	6511090	c.1218G>A/c.1260T>A	{"DPYD": {"c.1218G>A": 1, "c.1260T>A": 1}}	\N
6512504	6511090	c.775A>G/c.1294G>A	{"DPYD": {"c.775A>G": 1, "c.1294G>A": 1}}	\N
6512505	6511090	c.3049G>A/c.3061G>C	{"DPYD": {"c.3049G>A": 1, "c.3061G>C": 1}}	\N
6512506	6511090	c.46C>G/c.775A>G	{"DPYD": {"c.46C>G": 1, "c.775A>G": 1}}	\N
6512507	6511090	c.2161G>A/c.2482G>A	{"DPYD": {"c.2161G>A": 1, "c.2482G>A": 1}}	\N
6512508	6511090	c.1358C>G/c.1358C>G	{"DPYD": {"c.1358C>G": 2}}	\N
6512509	6511090	c.496A>G/c.1218G>A	{"DPYD": {"c.496A>G": 1, "c.1218G>A": 1}}	\N
6512510	6511090	c.929T>C/c.929T>C	{"DPYD": {"c.929T>C": 2}}	\N
6512511	6511090	c.775A>G/c.2161G>A	{"DPYD": {"c.775A>G": 1, "c.2161G>A": 1}}	\N
6512512	6511090	c.451A>G/c.3067C>A	{"DPYD": {"c.451A>G": 1, "c.3067C>A": 1}}	\N
6512513	6511090	c.2482G>A/c.3061G>C	{"DPYD": {"c.2482G>A": 1, "c.3061G>C": 1}}	\N
6512514	6511090	c.1906A>C/c.2582A>G	{"DPYD": {"c.1906A>C": 1, "c.2582A>G": 1}}	\N
6512515	6511090	c.451A>G/c.2303C>A	{"DPYD": {"c.451A>G": 1, "c.2303C>A": 1}}	\N
6512516	6511090	c.451A>G/c.1278G>T	{"DPYD": {"c.451A>G": 1, "c.1278G>T": 1}}	\N
6512517	6511090	c.1003G>T (*11)/c.1403C>A	{"DPYD": {"c.1403C>A": 1, "c.1003G>T (*11)": 1}}	\N
6512518	6511090	c.2161G>A/c.2161G>A	{"DPYD": {"c.2161G>A": 2}}	\N
6512519	6511090	c.1003G>T (*11)/c.1358C>G	{"DPYD": {"c.1358C>G": 1, "c.1003G>T (*11)": 1}}	\N
6512520	6511090	c.775A>G/c.1371C>T	{"DPYD": {"c.775A>G": 1, "c.1371C>T": 1}}	\N
6512521	6511090	c.1543G>A/c.2978T>G	{"DPYD": {"c.1543G>A": 1, "c.2978T>G": 1}}	\N
6512522	6511090	c.498G>A/c.1180C>T	{"DPYD": {"c.498G>A": 1, "c.1180C>T": 1}}	\N
6512523	6511090	c.934C>T/c.2582A>G	{"DPYD": {"c.934C>T": 1, "c.2582A>G": 1}}	\N
6512524	6511090	c.62G>A/Reference	{"DPYD": {"c.62G>A": 1, "Reference": 1}}	\N
6512525	6511090	c.1371C>T/c.2657G>A (*9B)	{"DPYD": {"c.1371C>T": 1, "c.2657G>A (*9B)": 1}}	\N
6512526	6511090	c.1371C>T/c.2195T>G	{"DPYD": {"c.1371C>T": 1, "c.2195T>G": 1}}	\N
6512527	6511090	c.1108A>G/c.1682G>T	{"DPYD": {"c.1108A>G": 1, "c.1682G>T": 1}}	\N
6512528	6511090	c.85T>C (*9A)/c.2656C>T	{"DPYD": {"c.2656C>T": 1, "c.85T>C (*9A)": 1}}	\N
6512529	6511090	c.85T>C (*9A)/c.1218G>A	{"DPYD": {"c.1218G>A": 1, "c.85T>C (*9A)": 1}}	\N
6512530	6511090	c.1294G>A/Reference	{"DPYD": {"Reference": 1, "c.1294G>A": 1}}	\N
6512531	6511090	c.1601G>A (*4)/c.2336C>A	{"DPYD": {"c.2336C>A": 1, "c.1601G>A (*4)": 1}}	\N
6512532	6511090	c.2915A>G/Reference	{"DPYD": {"Reference": 1, "c.2915A>G": 1}}	\N
6512533	6511090	c.1577C>G/c.1615G>A	{"DPYD": {"c.1577C>G": 1, "c.1615G>A": 1}}	\N
6512534	6511090	c.496A>G/c.2656C>T	{"DPYD": {"c.496A>G": 1, "c.2656C>T": 1}}	\N
6512535	6511090	c.62G>A/c.2921A>T	{"DPYD": {"c.62G>A": 1, "c.2921A>T": 1}}	\N
6512536	6511090	c.1796T>C/c.2194G>A (*6)	{"DPYD": {"c.1796T>C": 1, "c.2194G>A (*6)": 1}}	\N
6512537	6511090	c.1403C>A/c.2977C>T	{"DPYD": {"c.1403C>A": 1, "c.2977C>T": 1}}	\N
6512538	6511090	c.1003G>T (*11)/c.2921A>T	{"DPYD": {"c.2921A>T": 1, "c.1003G>T (*11)": 1}}	\N
6512539	6511090	c.496A>G/c.967G>A	{"DPYD": {"c.496A>G": 1, "c.967G>A": 1}}	\N
6512540	6511090	c.343A>G/c.1180C>T	{"DPYD": {"c.343A>G": 1, "c.1180C>T": 1}}	\N
6512541	6511090	c.1905C>G/c.2336C>A	{"DPYD": {"c.1905C>G": 1, "c.2336C>A": 1}}	\N
6512542	6511090	c.1796T>C/c.3061G>C	{"DPYD": {"c.1796T>C": 1, "c.3061G>C": 1}}	\N
6512543	6511090	c.1108A>G/c.1601G>A (*4)	{"DPYD": {"c.1108A>G": 1, "c.1601G>A (*4)": 1}}	\N
6512544	6511090	c.1371C>T/c.1796T>C	{"DPYD": {"c.1371C>T": 1, "c.1796T>C": 1}}	\N
6512545	6511090	c.1990G>T/c.2978T>G	{"DPYD": {"c.1990G>T": 1, "c.2978T>G": 1}}	\N
6512546	6511090	c.2194G>A (*6)/c.2482G>A	{"DPYD": {"c.2482G>A": 1, "c.2194G>A (*6)": 1}}	\N
6512547	6511090	c.1682G>T/c.2915A>G	{"DPYD": {"c.1682G>T": 1, "c.2915A>G": 1}}	\N
6512548	6511090	c.1682G>T/c.2977C>T	{"DPYD": {"c.1682G>T": 1, "c.2977C>T": 1}}	\N
6512549	6511090	c.1371C>T/c.1577C>G	{"DPYD": {"c.1371C>T": 1, "c.1577C>G": 1}}	\N
6512550	6511090	c.1180C>T/c.2978T>G	{"DPYD": {"c.1180C>T": 1, "c.2978T>G": 1}}	\N
6512551	6511090	c.498G>A/c.1108A>G	{"DPYD": {"c.498G>A": 1, "c.1108A>G": 1}}	\N
6512552	6511090	c.775A>G/c.1181G>T	{"DPYD": {"c.775A>G": 1, "c.1181G>T": 1}}	\N
6512553	6511090	c.2623A>C/c.3061G>C	{"DPYD": {"c.2623A>C": 1, "c.3061G>C": 1}}	\N
6512554	6511090	c.1896T>C/c.2186C>T	{"DPYD": {"c.1896T>C": 1, "c.2186C>T": 1}}	\N
6512555	6511090	c.2657G>A (*9B)/c.3049G>A	{"DPYD": {"c.3049G>A": 1, "c.2657G>A (*9B)": 1}}	\N
6512556	6511090	c.1403C>A/c.2336C>A	{"DPYD": {"c.1403C>A": 1, "c.2336C>A": 1}}	\N
6512557	6511090	c.2582A>G/Reference	{"DPYD": {"Reference": 1, "c.2582A>G": 1}}	\N
6512558	6511090	c.775A>G/c.1615G>A	{"DPYD": {"c.775A>G": 1, "c.1615G>A": 1}}	\N
6512559	6511090	c.1403C>A/c.1627A>G (*5)	{"DPYD": {"c.1403C>A": 1, "c.1627A>G (*5)": 1}}	\N
6512560	6511090	c.1003G>T (*11)/c.1796T>C	{"DPYD": {"c.1796T>C": 1, "c.1003G>T (*11)": 1}}	\N
6512561	6511090	c.62G>A/c.1294G>A	{"DPYD": {"c.62G>A": 1, "c.1294G>A": 1}}	\N
6512562	6511090	c.2195T>G/c.3049G>A	{"DPYD": {"c.2195T>G": 1, "c.3049G>A": 1}}	\N
6512563	6511090	c.2657G>A (*9B)/c.2657G>A (*9B)	{"DPYD": {"c.2657G>A (*9B)": 2}}	\N
6512564	6511090	c.46C>G/c.1601G>A (*4)	{"DPYD": {"c.46C>G": 1, "c.1601G>A (*4)": 1}}	\N
6512565	6511090	c.1896T>C/c.2915A>G	{"DPYD": {"c.1896T>C": 1, "c.2915A>G": 1}}	\N
6512566	6511090	c.1519G>A/c.2921A>T	{"DPYD": {"c.1519G>A": 1, "c.2921A>T": 1}}	\N
6512567	6511090	c.62G>A/c.2161G>A	{"DPYD": {"c.62G>A": 1, "c.2161G>A": 1}}	\N
6512568	6511090	c.1358C>G/c.1796T>C	{"DPYD": {"c.1358C>G": 1, "c.1796T>C": 1}}	\N
6512569	6511090	c.934C>T/c.3061G>C	{"DPYD": {"c.934C>T": 1, "c.3061G>C": 1}}	\N
6512570	6511090	c.1294G>A/c.2303C>A	{"DPYD": {"c.1294G>A": 1, "c.2303C>A": 1}}	\N
6512571	6511090	c.1358C>G/c.1403C>A	{"DPYD": {"c.1358C>G": 1, "c.1403C>A": 1}}	\N
6512572	6511090	c.1003G>T (*11)/c.1371C>T	{"DPYD": {"c.1371C>T": 1, "c.1003G>T (*11)": 1}}	\N
6512573	6511090	c.1682G>T/c.2186C>T	{"DPYD": {"c.1682G>T": 1, "c.2186C>T": 1}}	\N
6512574	6511090	c.1108A>G/c.3049G>A	{"DPYD": {"c.1108A>G": 1, "c.3049G>A": 1}}	\N
6512575	6511090	c.62G>A/c.1278G>T	{"DPYD": {"c.62G>A": 1, "c.1278G>T": 1}}	\N
6512576	6511090	c.2303C>A/c.2482G>A	{"DPYD": {"c.2303C>A": 1, "c.2482G>A": 1}}	\N
6512577	6511090	c.1358C>G/c.1371C>T	{"DPYD": {"c.1358C>G": 1, "c.1371C>T": 1}}	\N
6512578	6511090	c.1615G>A/c.2978T>G	{"DPYD": {"c.1615G>A": 1, "c.2978T>G": 1}}	\N
6512579	6511090	c.1181G>T/c.1294G>A	{"DPYD": {"c.1181G>T": 1, "c.1294G>A": 1}}	\N
6512580	6511090	c.1906A>C/c.2915A>G	{"DPYD": {"c.1906A>C": 1, "c.2915A>G": 1}}	\N
6512581	6511090	c.2915A>G/c.2921A>T	{"DPYD": {"c.2915A>G": 1, "c.2921A>T": 1}}	\N
6512582	6511090	c.525G>A/c.2978T>G	{"DPYD": {"c.525G>A": 1, "c.2978T>G": 1}}	\N
6512583	6511090	c.1181G>T/c.2161G>A	{"DPYD": {"c.1181G>T": 1, "c.2161G>A": 1}}	\N
6512584	6511090	c.1278G>T/c.2977C>T	{"DPYD": {"c.1278G>T": 1, "c.2977C>T": 1}}	\N
6512585	6511090	c.451A>G/c.1543G>A	{"DPYD": {"c.451A>G": 1, "c.1543G>A": 1}}	\N
6512586	6511090	c.1796T>C/c.2582A>G	{"DPYD": {"c.1796T>C": 1, "c.2582A>G": 1}}	\N
6512587	6511090	c.525G>A/c.2915A>G	{"DPYD": {"c.525G>A": 1, "c.2915A>G": 1}}	\N
6512588	6511090	c.1180C>T/c.1627A>G (*5)	{"DPYD": {"c.1180C>T": 1, "c.1627A>G (*5)": 1}}	\N
6512589	6511090	c.1108A>G/c.2623A>C	{"DPYD": {"c.1108A>G": 1, "c.2623A>C": 1}}	\N
6512590	6511090	c.498G>A/c.2195T>G	{"DPYD": {"c.498G>A": 1, "c.2195T>G": 1}}	\N
6512591	6511090	c.498G>A/c.2657G>A (*9B)	{"DPYD": {"c.498G>A": 1, "c.2657G>A (*9B)": 1}}	\N
6512592	6511090	c.85T>C (*9A)/c.1278G>T	{"DPYD": {"c.1278G>T": 1, "c.85T>C (*9A)": 1}}	\N
6512593	6511090	c.1371C>T/c.1403C>A	{"DPYD": {"c.1371C>T": 1, "c.1403C>A": 1}}	\N
6512594	6511090	c.929T>C/c.3067C>A	{"DPYD": {"c.929T>C": 1, "c.3067C>A": 1}}	\N
6512595	6511090	c.1180C>T/c.2195T>G	{"DPYD": {"c.1180C>T": 1, "c.2195T>G": 1}}	\N
6512596	6511090	c.1371C>T/c.3049G>A	{"DPYD": {"c.1371C>T": 1, "c.3049G>A": 1}}	\N
6512597	6511090	c.1796T>C/c.1905C>G	{"DPYD": {"c.1796T>C": 1, "c.1905C>G": 1}}	\N
6512598	6511090	c.1180C>T/c.1905C>G	{"DPYD": {"c.1180C>T": 1, "c.1905C>G": 1}}	\N
6512599	6511090	c.775A>G/c.2921A>T	{"DPYD": {"c.775A>G": 1, "c.2921A>T": 1}}	\N
6512600	6511090	c.1218G>A/c.2977C>T	{"DPYD": {"c.1218G>A": 1, "c.2977C>T": 1}}	\N
6512601	6511090	c.1180C>T/c.2657G>A (*9B)	{"DPYD": {"c.1180C>T": 1, "c.2657G>A (*9B)": 1}}	\N
6512602	6511090	c.85T>C (*9A)/c.3067C>A	{"DPYD": {"c.3067C>A": 1, "c.85T>C (*9A)": 1}}	\N
6512603	6511090	c.1896T>C/c.2582A>G	{"DPYD": {"c.1896T>C": 1, "c.2582A>G": 1}}	\N
6512604	6511090	c.1905C>G/c.1906A>C	{"DPYD": {"c.1905C>G": 1, "c.1906A>C": 1}}	\N
6512605	6511090	c.1108A>G/c.2195T>G	{"DPYD": {"c.1108A>G": 1, "c.2195T>G": 1}}	\N
6512606	6511090	c.1108A>G/c.2657G>A (*9B)	{"DPYD": {"c.1108A>G": 1, "c.2657G>A (*9B)": 1}}	\N
6512607	6511090	c.1403C>A/c.1519G>A	{"DPYD": {"c.1403C>A": 1, "c.1519G>A": 1}}	\N
6512608	6511090	c.62G>A/c.1615G>A	{"DPYD": {"c.62G>A": 1, "c.1615G>A": 1}}	\N
6512609	6511090	c.934C>T/c.1896T>C	{"DPYD": {"c.934C>T": 1, "c.1896T>C": 1}}	\N
6512610	6511090	c.1108A>G/c.1349C>T	{"DPYD": {"c.1108A>G": 1, "c.1349C>T": 1}}	\N
6512611	6511090	c.1003G>T (*11)/c.1003G>T (*11)	{"DPYD": {"c.1003G>T (*11)": 2}}	\N
6512612	6511090	c.1260T>A/c.2977C>T	{"DPYD": {"c.1260T>A": 1, "c.2977C>T": 1}}	\N
6512613	6511090	c.46C>G/c.1627A>G (*5)	{"DPYD": {"c.46C>G": 1, "c.1627A>G (*5)": 1}}	\N
6512614	6511090	c.1260T>A/c.2336C>A	{"DPYD": {"c.1260T>A": 1, "c.2336C>A": 1}}	\N
6512615	6511090	c.62G>A/c.62G>A	{"DPYD": {"c.62G>A": 2}}	\N
6512616	6511090	c.2161G>A/c.2303C>A	{"DPYD": {"c.2161G>A": 1, "c.2303C>A": 1}}	\N
6512617	6511090	c.62G>A/c.1181G>T	{"DPYD": {"c.62G>A": 1, "c.1181G>T": 1}}	\N
6512618	6511090	c.2623A>C/c.2977C>T	{"DPYD": {"c.2623A>C": 1, "c.2977C>T": 1}}	\N
6512619	6511090	c.1294G>A/c.3067C>A	{"DPYD": {"c.1294G>A": 1, "c.3067C>A": 1}}	\N
6512620	6511090	c.775A>G/Reference	{"DPYD": {"c.775A>G": 1, "Reference": 1}}	\N
6512621	6511090	c.934C>T/c.1990G>T	{"DPYD": {"c.934C>T": 1, "c.1990G>T": 1}}	\N
6512622	6511090	c.451A>G/c.2482G>A	{"DPYD": {"c.451A>G": 1, "c.2482G>A": 1}}	\N
6512623	6511090	c.46C>G/c.3061G>C	{"DPYD": {"c.46C>G": 1, "c.3061G>C": 1}}	\N
6512624	6511090	c.967G>A/c.1278G>T	{"DPYD": {"c.967G>A": 1, "c.1278G>T": 1}}	\N
6512625	6511090	c.1796T>C/c.2623A>C	{"DPYD": {"c.1796T>C": 1, "c.2623A>C": 1}}	\N
6512626	6511090	c.2161G>A/c.3067C>A	{"DPYD": {"c.2161G>A": 1, "c.3067C>A": 1}}	\N
6512627	6511090	c.1905C>G/c.2186C>T	{"DPYD": {"c.1905C>G": 1, "c.2186C>T": 1}}	\N
6512628	6511090	c.85T>C (*9A)/c.2303C>A	{"DPYD": {"c.2303C>A": 1, "c.85T>C (*9A)": 1}}	\N
6512629	6511090	c.1906A>C/c.2623A>C	{"DPYD": {"c.1906A>C": 1, "c.2623A>C": 1}}	\N
6512630	6511090	c.525G>A/c.1349C>T	{"DPYD": {"c.525G>A": 1, "c.1349C>T": 1}}	\N
6512631	6511090	c.1180C>T/c.2915A>G	{"DPYD": {"c.1180C>T": 1, "c.2915A>G": 1}}	\N
6512632	6511090	c.498G>A/c.2978T>G	{"DPYD": {"c.498G>A": 1, "c.2978T>G": 1}}	\N
6512633	6511090	c.1278G>T/c.2336C>A	{"DPYD": {"c.1278G>T": 1, "c.2336C>A": 1}}	\N
6512634	6511090	c.1682G>T/c.2582A>G	{"DPYD": {"c.1682G>T": 1, "c.2582A>G": 1}}	\N
6512635	6511090	c.1896T>C/c.1905C>G	{"DPYD": {"c.1896T>C": 1, "c.1905C>G": 1}}	\N
6512636	6511090	c.1403C>A/c.1896T>C	{"DPYD": {"c.1403C>A": 1, "c.1896T>C": 1}}	\N
6512637	6511090	c.46C>G/c.1682G>T	{"DPYD": {"c.46C>G": 1, "c.1682G>T": 1}}	\N
6512638	6511090	c.498G>A/c.1349C>T	{"DPYD": {"c.498G>A": 1, "c.1349C>T": 1}}	\N
6512639	6511090	c.1905C>G/c.3061G>C	{"DPYD": {"c.1905C>G": 1, "c.3061G>C": 1}}	\N
6512640	6511090	c.1796T>C/c.2915A>G	{"DPYD": {"c.1796T>C": 1, "c.2915A>G": 1}}	\N
6512641	6511090	c.1180C>T/c.2623A>C	{"DPYD": {"c.1180C>T": 1, "c.2623A>C": 1}}	\N
6512642	6511090	c.929T>C/c.1278G>T	{"DPYD": {"c.929T>C": 1, "c.1278G>T": 1}}	\N
6512643	6511090	c.343A>G/c.1003G>T (*11)	{"DPYD": {"c.343A>G": 1, "c.1003G>T (*11)": 1}}	\N
6512644	6511090	c.1905C>G/c.1990G>T	{"DPYD": {"c.1905C>G": 1, "c.1990G>T": 1}}	\N
6512645	6511090	c.1403C>A/c.2582A>G	{"DPYD": {"c.1403C>A": 1, "c.2582A>G": 1}}	\N
6512646	6511090	c.1003G>T (*11)/c.1577C>G	{"DPYD": {"c.1577C>G": 1, "c.1003G>T (*11)": 1}}	\N
6512647	6511090	c.1577C>G/Reference	{"DPYD": {"Reference": 1, "c.1577C>G": 1}}	\N
6512648	6511090	c.313G>A/c.1218G>A	{"DPYD": {"c.313G>A": 1, "c.1218G>A": 1}}	\N
6512649	6511090	c.934C>T/c.1906A>C	{"DPYD": {"c.934C>T": 1, "c.1906A>C": 1}}	\N
6512650	6511090	c.1905C>G/c.2977C>T	{"DPYD": {"c.1905C>G": 1, "c.2977C>T": 1}}	\N
6512651	6511090	c.1403C>A/c.3061G>C	{"DPYD": {"c.1403C>A": 1, "c.3061G>C": 1}}	\N
6512652	6511090	c.1260T>A/c.1906A>C	{"DPYD": {"c.1260T>A": 1, "c.1906A>C": 1}}	\N
6512653	6511090	c.1218G>A/c.2336C>A	{"DPYD": {"c.1218G>A": 1, "c.2336C>A": 1}}	\N
6512654	6511090	c.2303C>A/c.2303C>A	{"DPYD": {"c.2303C>A": 2}}	\N
6512655	6511090	c.3067C>A/c.3067C>A	{"DPYD": {"c.3067C>A": 2}}	\N
6512656	6511090	c.1218G>A/c.1906A>C	{"DPYD": {"c.1218G>A": 1, "c.1906A>C": 1}}	\N
6512657	6511090	c.2303C>A/c.3067C>A	{"DPYD": {"c.2303C>A": 1, "c.3067C>A": 1}}	\N
6512658	6511090	c.2186C>T/c.3061G>C	{"DPYD": {"c.2186C>T": 1, "c.3061G>C": 1}}	\N
6512659	6511090	c.1601G>A (*4)/c.2656C>T	{"DPYD": {"c.2656C>T": 1, "c.1601G>A (*4)": 1}}	\N
6512660	6511090	c.451A>G/c.934C>T	{"DPYD": {"c.451A>G": 1, "c.934C>T": 1}}	\N
6512661	6511090	c.2186C>T/c.2582A>G	{"DPYD": {"c.2186C>T": 1, "c.2582A>G": 1}}	\N
6512662	6511090	c.1294G>A/c.2161G>A	{"DPYD": {"c.1294G>A": 1, "c.2161G>A": 1}}	\N
6512663	6511090	c.313G>A/c.1543G>A	{"DPYD": {"c.313G>A": 1, "c.1543G>A": 1}}	\N
6512664	6511090	c.929T>C/c.2303C>A	{"DPYD": {"c.929T>C": 1, "c.2303C>A": 1}}	\N
6512665	6511090	c.1627A>G (*5)/c.2482G>A	{"DPYD": {"c.2482G>A": 1, "c.1627A>G (*5)": 1}}	\N
6512666	6511090	c.1543G>A/c.1796T>C	{"DPYD": {"c.1543G>A": 1, "c.1796T>C": 1}}	\N
6512667	6511090	c.496A>G/c.1543G>A	{"DPYD": {"c.496A>G": 1, "c.1543G>A": 1}}	\N
6512668	6511090	c.46C>G/c.2582A>G	{"DPYD": {"c.46C>G": 1, "c.2582A>G": 1}}	\N
6512669	6511090	c.525G>A/c.2657G>A (*9B)	{"DPYD": {"c.525G>A": 1, "c.2657G>A (*9B)": 1}}	\N
6512670	6511090	c.525G>A/c.2195T>G	{"DPYD": {"c.525G>A": 1, "c.2195T>G": 1}}	\N
6512671	6511090	c.46C>G/c.1519G>A	{"DPYD": {"c.46C>G": 1, "c.1519G>A": 1}}	\N
6512672	6511090	c.496A>G/c.2482G>A	{"DPYD": {"c.496A>G": 1, "c.2482G>A": 1}}	\N
6512673	6511090	c.46C>G/c.1260T>A	{"DPYD": {"c.46C>G": 1, "c.1260T>A": 1}}	\N
6512674	6511090	c.1349C>T/c.1371C>T	{"DPYD": {"c.1349C>T": 1, "c.1371C>T": 1}}	\N
6512675	6511090	c.313G>A/c.2482G>A	{"DPYD": {"c.313G>A": 1, "c.2482G>A": 1}}	\N
6512676	6511090	c.1108A>G/c.2194G>A (*6)	{"DPYD": {"c.1108A>G": 1, "c.2194G>A (*6)": 1}}	\N
6512677	6511090	c.2582A>G/c.2921A>T	{"DPYD": {"c.2582A>G": 1, "c.2921A>T": 1}}	\N
6512678	6511090	c.343A>G/c.1371C>T	{"DPYD": {"c.343A>G": 1, "c.1371C>T": 1}}	\N
6512679	6511090	c.1181G>T/c.1181G>T	{"DPYD": {"c.1181G>T": 2}}	\N
6512680	6511090	c.85T>C (*9A)/c.934C>T	{"DPYD": {"c.934C>T": 1, "c.85T>C (*9A)": 1}}	\N
6512681	6511090	c.1403C>A/c.2186C>T	{"DPYD": {"c.1403C>A": 1, "c.2186C>T": 1}}	\N
6512682	6511090	c.1278G>T/c.1906A>C	{"DPYD": {"c.1278G>T": 1, "c.1906A>C": 1}}	\N
6512683	6511090	c.1181G>T/c.1615G>A	{"DPYD": {"c.1181G>T": 1, "c.1615G>A": 1}}	\N
6512684	6511090	c.2186C>T/c.2186C>T	{"DPYD": {"c.2186C>T": 2}}	\N
6512685	6511090	c.2194G>A (*6)/c.2656C>T	{"DPYD": {"c.2656C>T": 1, "c.2194G>A (*6)": 1}}	\N
6512686	6511090	c.1358C>G/c.1577C>G	{"DPYD": {"c.1358C>G": 1, "c.1577C>G": 1}}	\N
6512689	6512688	c.1129-5923C>G/c.1349C>T	{"DPYD": {"c.1349C>T": 1, "c.1129-5923C>G": 1}}	\N
6512690	6512688	c.2623A>C/c.2846A>T	{"DPYD": {"c.2623A>C": 1, "c.2846A>T": 1}}	\N
6512691	6512688	c.557A>G/c.967G>A	{"DPYD": {"c.557A>G": 1, "c.967G>A": 1}}	\N
6512692	6512688	c.1129-5923C>G, c.1236G>A (HapB3)/c.1403C>A	{"DPYD": {"c.1403C>A": 1, "c.1129-5923C>G, c.1236G>A (HapB3)": 1}}	\N
6512693	6512688	c.313G>A/c.2279C>T	{"DPYD": {"c.313G>A": 1, "c.2279C>T": 1}}	\N
6512694	6512688	c.868A>G/c.1796T>C	{"DPYD": {"c.868A>G": 1, "c.1796T>C": 1}}	\N
6512695	6512688	c.557A>G/c.2186C>T	{"DPYD": {"c.557A>G": 1, "c.2186C>T": 1}}	\N
6512696	6512688	c.1129-5923C>G/c.1615G>A	{"DPYD": {"c.1615G>A": 1, "c.1129-5923C>G": 1}}	\N
6512697	6512688	c.868A>G/c.1615G>A	{"DPYD": {"c.868A>G": 1, "c.1615G>A": 1}}	\N
6512698	6512688	c.1129-5923C>G/c.2582A>G	{"DPYD": {"c.2582A>G": 1, "c.1129-5923C>G": 1}}	\N
6512699	6512688	c.557A>G/c.1218G>A	{"DPYD": {"c.557A>G": 1, "c.1218G>A": 1}}	\N
6512700	6512688	c.2279C>T/c.2582A>G	{"DPYD": {"c.2279C>T": 1, "c.2582A>G": 1}}	\N
6512701	6512688	c.1371C>T/c.2279C>T	{"DPYD": {"c.1371C>T": 1, "c.2279C>T": 1}}	\N
6512702	6512688	c.1129-5923C>G, c.1236G>A (HapB3)/c.3061G>C	{"DPYD": {"c.3061G>C": 1, "c.1129-5923C>G, c.1236G>A (HapB3)": 1}}	\N
6512703	6512688	c.343A>G/c.1129-5923C>G, c.1236G>A (HapB3)	{"DPYD": {"c.343A>G": 1, "c.1129-5923C>G, c.1236G>A (HapB3)": 1}}	\N
6512704	6512688	c.1129-5923C>G, c.1236G>A (HapB3)/c.1358C>G	{"DPYD": {"c.1358C>G": 1, "c.1129-5923C>G, c.1236G>A (HapB3)": 1}}	\N
6512705	6512688	c.1577C>G/c.2279C>T	{"DPYD": {"c.1577C>G": 1, "c.2279C>T": 1}}	\N
6512706	6512688	c.1129-5923C>G, c.1236G>A (HapB3)/c.1906A>C	{"DPYD": {"c.1906A>C": 1, "c.1129-5923C>G, c.1236G>A (HapB3)": 1}}	\N
6512707	6512688	c.557A>G/c.929T>C	{"DPYD": {"c.557A>G": 1, "c.929T>C": 1}}	\N
6512708	6512688	c.1129-5923C>G, c.1236G>A (HapB3)/c.1543G>A	{"DPYD": {"c.1543G>A": 1, "c.1129-5923C>G, c.1236G>A (HapB3)": 1}}	\N
6512709	6512688	c.868A>G/c.1349C>T	{"DPYD": {"c.868A>G": 1, "c.1349C>T": 1}}	\N
6512710	6512688	c.775A>G/c.2279C>T	{"DPYD": {"c.775A>G": 1, "c.2279C>T": 1}}	\N
6512711	6512688	c.2846A>T/c.2978T>G	{"DPYD": {"c.2846A>T": 1, "c.2978T>G": 1}}	\N
6512712	6512688	c.934C>T/c.2279C>T	{"DPYD": {"c.934C>T": 1, "c.2279C>T": 1}}	\N
6512713	6512688	c.2582A>G/c.2846A>T	{"DPYD": {"c.2582A>G": 1, "c.2846A>T": 1}}	\N
6512714	6512688	c.1314T>G/c.2915A>G	{"DPYD": {"c.1314T>G": 1, "c.2915A>G": 1}}	\N
6512715	6512688	c.868A>G/c.2482G>A	{"DPYD": {"c.868A>G": 1, "c.2482G>A": 1}}	\N
6512716	6512688	c.1129-5923C>G, c.1236G>A (HapB3)/c.1896T>C	{"DPYD": {"c.1896T>C": 1, "c.1129-5923C>G, c.1236G>A (HapB3)": 1}}	\N
6512717	6512688	c.1129-5923C>G, c.1236G>A (HapB3)/c.2623A>C	{"DPYD": {"c.2623A>C": 1, "c.1129-5923C>G, c.1236G>A (HapB3)": 1}}	\N
6512718	6512688	c.2846A>T/c.2977C>T	{"DPYD": {"c.2846A>T": 1, "c.2977C>T": 1}}	\N
6512719	6512688	c.1129-5923C>G, c.1236G>A (HapB3)/c.3049G>A	{"DPYD": {"c.3049G>A": 1, "c.1129-5923C>G, c.1236G>A (HapB3)": 1}}	\N
6512720	6512688	c.868A>G/c.2582A>G	{"DPYD": {"c.868A>G": 1, "c.2582A>G": 1}}	\N
6512721	6512688	c.2279C>T/c.2657G>A (*9B)	{"DPYD": {"c.2279C>T": 1, "c.2657G>A (*9B)": 1}}	\N
6512722	6512688	c.46C>G/c.2279C>T	{"DPYD": {"c.46C>G": 1, "c.2279C>T": 1}}	\N
6512723	6512688	c.1129-5923C>G/c.1181G>T	{"DPYD": {"c.1181G>T": 1, "c.1129-5923C>G": 1}}	\N
6512724	6512688	c.1990G>T/c.2846A>T	{"DPYD": {"c.1990G>T": 1, "c.2846A>T": 1}}	\N
6512725	6512688	c.1129-5923C>G, c.1236G>A (HapB3)/Reference	{"DPYD": {"Reference": 1, "c.1129-5923C>G, c.1236G>A (HapB3)": 1}}	\N
6512726	6512688	c.1180C>T/c.1314T>G	{"DPYD": {"c.1180C>T": 1, "c.1314T>G": 1}}	\N
6512727	6512688	c.1129-5923C>G/c.2195T>G	{"DPYD": {"c.2195T>G": 1, "c.1129-5923C>G": 1}}	\N
6512728	6512688	c.1129-5923C>G/c.2657G>A (*9B)	{"DPYD": {"c.1129-5923C>G": 1, "c.2657G>A (*9B)": 1}}	\N
6512729	6512688	c.1627A>G (*5)/c.2279C>T	{"DPYD": {"c.2279C>T": 1, "c.1627A>G (*5)": 1}}	\N
6512730	6512688	c.1129-5923C>G, c.1236G>A (HapB3)/c.2303C>A	{"DPYD": {"c.2303C>A": 1, "c.1129-5923C>G, c.1236G>A (HapB3)": 1}}	\N
6512731	6512688	c.85T>C (*9A)/c.1129-5923C>G, c.1236G>A (HapB3)	{"DPYD": {"c.85T>C (*9A)": 1, "c.1129-5923C>G, c.1236G>A (HapB3)": 1}}	\N
6512732	6512688	c.1129-5923C>G, c.1236G>A (HapB3)/c.2194G>A (*6)	{"DPYD": {"c.2194G>A (*6)": 1, "c.1129-5923C>G, c.1236G>A (HapB3)": 1}}	\N
6512733	6512688	c.62G>A/c.2846A>T	{"DPYD": {"c.62G>A": 1, "c.2846A>T": 1}}	\N
6512734	6512688	c.557A>G/c.1180C>T	{"DPYD": {"c.557A>G": 1, "c.1180C>T": 1}}	\N
6512735	6512688	c.1601G>A (*4)/c.2846A>T	{"DPYD": {"c.2846A>T": 1, "c.1601G>A (*4)": 1}}	\N
6512736	6512688	c.85T>C (*9A)/c.557A>G	{"DPYD": {"c.557A>G": 1, "c.85T>C (*9A)": 1}}	\N
6512737	6512688	c.868A>G/c.2194G>A (*6)	{"DPYD": {"c.868A>G": 1, "c.2194G>A (*6)": 1}}	\N
6512738	6512688	c.557A>G/c.2978T>G	{"DPYD": {"c.557A>G": 1, "c.2978T>G": 1}}	\N
6512739	6512688	c.2161G>A/c.2279C>T	{"DPYD": {"c.2161G>A": 1, "c.2279C>T": 1}}	\N
6512740	6512688	c.2195T>G/c.2279C>T	{"DPYD": {"c.2195T>G": 1, "c.2279C>T": 1}}	\N
6512741	6512688	c.557A>G/c.2336C>A	{"DPYD": {"c.557A>G": 1, "c.2336C>A": 1}}	\N
6512742	6512688	c.1314T>G/c.2582A>G	{"DPYD": {"c.1314T>G": 1, "c.2582A>G": 1}}	\N
6512743	6512688	c.1129-5923C>G/c.1260T>A	{"DPYD": {"c.1260T>A": 1, "c.1129-5923C>G": 1}}	\N
6512744	6512688	c.1796T>C/c.2279C>T	{"DPYD": {"c.1796T>C": 1, "c.2279C>T": 1}}	\N
6512745	6512688	c.2303C>A/c.2846A>T	{"DPYD": {"c.2303C>A": 1, "c.2846A>T": 1}}	\N
6512746	6512688	c.1108A>G/c.2279C>T	{"DPYD": {"c.1108A>G": 1, "c.2279C>T": 1}}	\N
6512747	6512688	c.1218G>A/c.2279C>T	{"DPYD": {"c.1218G>A": 1, "c.2279C>T": 1}}	\N
6512748	6512688	c.498G>A/c.557A>G	{"DPYD": {"c.498G>A": 1, "c.557A>G": 1}}	\N
6512749	6512688	c.868A>G/c.1358C>G	{"DPYD": {"c.868A>G": 1, "c.1358C>G": 1}}	\N
6512750	6512688	c.1181G>T/c.2279C>T	{"DPYD": {"c.1181G>T": 1, "c.2279C>T": 1}}	\N
6512751	6512688	c.557A>G/c.2656C>T	{"DPYD": {"c.557A>G": 1, "c.2656C>T": 1}}	\N
6512752	6512688	c.1129-5923C>G/c.2194G>A (*6)	{"DPYD": {"c.1129-5923C>G": 1, "c.2194G>A (*6)": 1}}	\N
6512753	6512688	c.868A>G/c.1260T>A	{"DPYD": {"c.868A>G": 1, "c.1260T>A": 1}}	\N
6512754	6512688	c.85T>C (*9A)/c.1314T>G	{"DPYD": {"c.1314T>G": 1, "c.85T>C (*9A)": 1}}	\N
6512755	6512688	c.1129-5923C>G, c.1236G>A (HapB3)/c.1990G>T	{"DPYD": {"c.1990G>T": 1, "c.1129-5923C>G, c.1236G>A (HapB3)": 1}}	\N
6512756	6512688	c.1905C>G/c.2846A>T	{"DPYD": {"c.1905C>G": 1, "c.2846A>T": 1}}	\N
6512757	6512688	c.557A>G/c.2977C>T	{"DPYD": {"c.557A>G": 1, "c.2977C>T": 1}}	\N
6512758	6512688	c.868A>G/c.1371C>T	{"DPYD": {"c.868A>G": 1, "c.1371C>T": 1}}	\N
6512759	6512688	c.343A>G/c.2279C>T	{"DPYD": {"c.343A>G": 1, "c.2279C>T": 1}}	\N
6512760	6512688	c.2194G>A (*6)/c.2279C>T	{"DPYD": {"c.2279C>T": 1, "c.2194G>A (*6)": 1}}	\N
6512761	6512688	c.967G>A/c.1129-5923C>G, c.1236G>A (HapB3)	{"DPYD": {"c.967G>A": 1, "c.1129-5923C>G, c.1236G>A (HapB3)": 1}}	\N
6512762	6512688	c.1129-5923C>G, c.1236G>A (HapB3)/c.1796T>C	{"DPYD": {"c.1796T>C": 1, "c.1129-5923C>G, c.1236G>A (HapB3)": 1}}	\N
6512763	6512688	c.498G>A/c.1129-5923C>G, c.1236G>A (HapB3)	{"DPYD": {"c.498G>A": 1, "c.1129-5923C>G, c.1236G>A (HapB3)": 1}}	\N
6512764	6512688	c.868A>G/c.1682G>T	{"DPYD": {"c.868A>G": 1, "c.1682G>T": 1}}	\N
6512765	6512688	c.1129-5923C>G, c.1236G>A (HapB3)/c.3067C>A	{"DPYD": {"c.3067C>A": 1, "c.1129-5923C>G, c.1236G>A (HapB3)": 1}}	\N
6512766	6512688	c.1129-5923C>G, c.1236G>A (HapB3)/c.1682G>T	{"DPYD": {"c.1682G>T": 1, "c.1129-5923C>G, c.1236G>A (HapB3)": 1}}	\N
6512767	6512688	c.868A>G/c.1181G>T	{"DPYD": {"c.868A>G": 1, "c.1181G>T": 1}}	\N
6512768	6512688	c.525G>A/c.868A>G	{"DPYD": {"c.525G>A": 1, "c.868A>G": 1}}	\N
6512769	6512688	c.2279C>T/c.2482G>A	{"DPYD": {"c.2279C>T": 1, "c.2482G>A": 1}}	\N
6512770	6512688	c.496A>G/c.868A>G	{"DPYD": {"c.496A>G": 1, "c.868A>G": 1}}	\N
6512771	6512688	c.868A>G/c.2195T>G	{"DPYD": {"c.868A>G": 1, "c.2195T>G": 1}}	\N
6512772	6512688	c.967G>A/c.1314T>G	{"DPYD": {"c.967G>A": 1, "c.1314T>G": 1}}	\N
6512773	6512688	c.451A>G/c.2846A>T	{"DPYD": {"c.451A>G": 1, "c.2846A>T": 1}}	\N
6512774	6512688	c.868A>G/c.2657G>A (*9B)	{"DPYD": {"c.868A>G": 1, "c.2657G>A (*9B)": 1}}	\N
6512775	6512688	c.451A>G/c.557A>G	{"DPYD": {"c.451A>G": 1, "c.557A>G": 1}}	\N
6512776	6512688	c.1906A>C/c.2279C>T	{"DPYD": {"c.1906A>C": 1, "c.2279C>T": 1}}	\N
6512777	6512688	c.1129-5923C>G, c.1236G>A (HapB3)/c.1601G>A (*4)	{"DPYD": {"c.1601G>A (*4)": 1, "c.1129-5923C>G, c.1236G>A (HapB3)": 1}}	\N
6512778	6512688	c.451A>G/c.1314T>G	{"DPYD": {"c.451A>G": 1, "c.1314T>G": 1}}	\N
6512779	6512688	c.557A>G/c.1627A>G (*5)	{"DPYD": {"c.557A>G": 1, "c.1627A>G (*5)": 1}}	\N
6512780	6512688	c.1129-5923C>G/c.1906A>C	{"DPYD": {"c.1906A>C": 1, "c.1129-5923C>G": 1}}	\N
6512781	6512688	c.1129-5923C>G, c.1236G>A (HapB3)/c.1371C>T	{"DPYD": {"c.1371C>T": 1, "c.1129-5923C>G, c.1236G>A (HapB3)": 1}}	\N
6512782	6512688	c.1129-5923C>G/c.2482G>A	{"DPYD": {"c.2482G>A": 1, "c.1129-5923C>G": 1}}	\N
6512783	6512688	c.1403C>A/c.2846A>T	{"DPYD": {"c.1403C>A": 1, "c.2846A>T": 1}}	\N
6512784	6512688	c.1896T>C/c.2279C>T	{"DPYD": {"c.1896T>C": 1, "c.2279C>T": 1}}	\N
6512785	6512688	c.85T>C (*9A)/c.868A>G	{"DPYD": {"c.868A>G": 1, "c.85T>C (*9A)": 1}}	\N
6512786	6512688	c.46C>G/c.1129-5923C>G, c.1236G>A (HapB3)	{"DPYD": {"c.46C>G": 1, "c.1129-5923C>G, c.1236G>A (HapB3)": 1}}	\N
6512787	6512688	c.868A>G/c.1627A>G (*5)	{"DPYD": {"c.868A>G": 1, "c.1627A>G (*5)": 1}}	\N
6512788	6512688	c.1129-5923C>G, c.1236G>A (HapB3)/c.2582A>G	{"DPYD": {"c.2582A>G": 1, "c.1129-5923C>G, c.1236G>A (HapB3)": 1}}	\N
6512789	6512688	c.2279C>T/Reference	{"DPYD": {"Reference": 1, "c.2279C>T": 1}}	\N
6512790	6512688	c.1129-5923C>G/c.1358C>G	{"DPYD": {"c.1358C>G": 1, "c.1129-5923C>G": 1}}	\N
6512791	6512688	c.1294G>A/c.2279C>T	{"DPYD": {"c.1294G>A": 1, "c.2279C>T": 1}}	\N
6512792	6512688	c.1108A>G/c.1129-5923C>G	{"DPYD": {"c.1108A>G": 1, "c.1129-5923C>G": 1}}	\N
6512793	6512688	c.62G>A/c.2279C>T	{"DPYD": {"c.62G>A": 1, "c.2279C>T": 1}}	\N
6512794	6512688	c.1615G>A/c.2846A>T	{"DPYD": {"c.1615G>A": 1, "c.2846A>T": 1}}	\N
6512795	6512688	c.557A>G/c.1349C>T	{"DPYD": {"c.557A>G": 1, "c.1349C>T": 1}}	\N
6512796	6512688	c.868A>G/c.1403C>A	{"DPYD": {"c.868A>G": 1, "c.1403C>A": 1}}	\N
6512797	6512688	c.1314T>G/c.2161G>A	{"DPYD": {"c.1314T>G": 1, "c.2161G>A": 1}}	\N
6512798	6512688	c.1129-5923C>G/c.3061G>C	{"DPYD": {"c.3061G>C": 1, "c.1129-5923C>G": 1}}	\N
6512799	6512688	c.1314T>G/c.2656C>T	{"DPYD": {"c.1314T>G": 1, "c.2656C>T": 1}}	\N
6512800	6512688	c.557A>G/c.1181G>T	{"DPYD": {"c.557A>G": 1, "c.1181G>T": 1}}	\N
6512801	6512688	c.1314T>G/c.1577C>G	{"DPYD": {"c.1314T>G": 1, "c.1577C>G": 1}}	\N
6512802	6512688	c.1796T>C/c.2846A>T	{"DPYD": {"c.1796T>C": 1, "c.2846A>T": 1}}	\N
6512803	6512688	c.1314T>G/c.2482G>A	{"DPYD": {"c.1314T>G": 1, "c.2482G>A": 1}}	\N
6512804	6512688	c.1129-5923C>G/c.3049G>A	{"DPYD": {"c.3049G>A": 1, "c.1129-5923C>G": 1}}	\N
6512805	6512688	c.1260T>A/c.2279C>T	{"DPYD": {"c.1260T>A": 1, "c.2279C>T": 1}}	\N
6512806	6512688	c.775A>G/c.2846A>T	{"DPYD": {"c.775A>G": 1, "c.2846A>T": 1}}	\N
6512807	6512688	c.868A>G/c.1180C>T	{"DPYD": {"c.868A>G": 1, "c.1180C>T": 1}}	\N
6512808	6512688	c.498G>A/c.868A>G	{"DPYD": {"c.498G>A": 1, "c.868A>G": 1}}	\N
6512809	6512688	c.2657G>A (*9B)/c.2846A>T	{"DPYD": {"c.2846A>T": 1, "c.2657G>A (*9B)": 1}}	\N
6512810	6512688	c.313G>A/c.1129-5923C>G, c.1236G>A (HapB3)	{"DPYD": {"c.313G>A": 1, "c.1129-5923C>G, c.1236G>A (HapB3)": 1}}	\N
6512811	6512688	c.2279C>T/c.2915A>G	{"DPYD": {"c.2279C>T": 1, "c.2915A>G": 1}}	\N
6512812	6512688	c.62G>A/c.1314T>G	{"DPYD": {"c.62G>A": 1, "c.1314T>G": 1}}	\N
6512813	6512688	c.868A>G/c.1601G>A (*4)	{"DPYD": {"c.868A>G": 1, "c.1601G>A (*4)": 1}}	\N
6512814	6512688	c.1129-5923C>G/c.2186C>T	{"DPYD": {"c.2186C>T": 1, "c.1129-5923C>G": 1}}	\N
6512815	6512688	c.1129-5923C>G, c.1236G>A (HapB3)/c.1349C>T	{"DPYD": {"c.1349C>T": 1, "c.1129-5923C>G, c.1236G>A (HapB3)": 1}}	\N
6512816	6512688	c.868A>G/c.1906A>C	{"DPYD": {"c.868A>G": 1, "c.1906A>C": 1}}	\N
6512817	6512688	c.498G>A/c.1314T>G	{"DPYD": {"c.498G>A": 1, "c.1314T>G": 1}}	\N
6512818	6512688	c.557A>G/c.1108A>G	{"DPYD": {"c.557A>G": 1, "c.1108A>G": 1}}	\N
6512819	6512688	c.1003G>T (*11)/c.1129-5923C>G	{"DPYD": {"c.1129-5923C>G": 1, "c.1003G>T (*11)": 1}}	\N
6512820	6512688	c.557A>G/c.1260T>A	{"DPYD": {"c.557A>G": 1, "c.1260T>A": 1}}	\N
6512821	6512688	c.1129-5923C>G, c.1236G>A (HapB3)/c.2482G>A	{"DPYD": {"c.2482G>A": 1, "c.1129-5923C>G, c.1236G>A (HapB3)": 1}}	\N
6512822	6512688	c.1129-5923C>G, c.1236G>A (HapB3)/c.2977C>T	{"DPYD": {"c.2977C>T": 1, "c.1129-5923C>G, c.1236G>A (HapB3)": 1}}	\N
6512823	6512688	c.868A>G/c.929T>C	{"DPYD": {"c.868A>G": 1, "c.929T>C": 1}}	\N
6512824	6512688	c.2194G>A (*6)/c.2846A>T	{"DPYD": {"c.2846A>T": 1, "c.2194G>A (*6)": 1}}	\N
6512825	6512688	c.1003G>T (*11)/c.2279C>T	{"DPYD": {"c.2279C>T": 1, "c.1003G>T (*11)": 1}}	\N
6512826	6512688	c.1906A>C/c.2846A>T	{"DPYD": {"c.1906A>C": 1, "c.2846A>T": 1}}	\N
6512827	6512688	c.1181G>T/c.1314T>G	{"DPYD": {"c.1181G>T": 1, "c.1314T>G": 1}}	\N
6512828	6512688	c.2186C>T/c.2846A>T	{"DPYD": {"c.2186C>T": 1, "c.2846A>T": 1}}	\N
6512829	6512688	c.62G>A/c.1129-5923C>G	{"DPYD": {"c.62G>A": 1, "c.1129-5923C>G": 1}}	\N
6512830	6512688	c.557A>G/c.1543G>A	{"DPYD": {"c.557A>G": 1, "c.1543G>A": 1}}	\N
6512831	6512688	c.775A>G/c.1129-5923C>G, c.1236G>A (HapB3)	{"DPYD": {"c.775A>G": 1, "c.1129-5923C>G, c.1236G>A (HapB3)": 1}}	\N
6512832	6512688	c.1278G>T/c.2279C>T	{"DPYD": {"c.1278G>T": 1, "c.2279C>T": 1}}	\N
6512833	6512688	c.1129-5923C>G/c.1294G>A	{"DPYD": {"c.1294G>A": 1, "c.1129-5923C>G": 1}}	\N
6512834	6512688	c.1129-5923C>G, c.1236G>A (HapB3)/c.2978T>G	{"DPYD": {"c.2978T>G": 1, "c.1129-5923C>G, c.1236G>A (HapB3)": 1}}	\N
6512835	6512688	c.62G>A/c.557A>G	{"DPYD": {"c.62G>A": 1, "c.557A>G": 1}}	\N
6512836	6512688	c.1129-5923C>G/c.2921A>T	{"DPYD": {"c.2921A>T": 1, "c.1129-5923C>G": 1}}	\N
6512837	6512688	c.1543G>A/c.2846A>T	{"DPYD": {"c.1543G>A": 1, "c.2846A>T": 1}}	\N
6512838	6512688	c.967G>A/c.2279C>T	{"DPYD": {"c.967G>A": 1, "c.2279C>T": 1}}	\N
6512839	6512688	c.313G>A/c.2846A>T	{"DPYD": {"c.313G>A": 1, "c.2846A>T": 1}}	\N
6512840	6512688	c.1314T>G/c.1403C>A	{"DPYD": {"c.1314T>G": 1, "c.1403C>A": 1}}	\N
6512841	6512688	c.868A>G/c.967G>A	{"DPYD": {"c.868A>G": 1, "c.967G>A": 1}}	\N
6512842	6512688	c.1129-5923C>G, c.1236G>A (HapB3)/c.2186C>T	{"DPYD": {"c.2186C>T": 1, "c.1129-5923C>G, c.1236G>A (HapB3)": 1}}	\N
6512843	6512688	c.557A>G/Reference	{"DPYD": {"c.557A>G": 1, "Reference": 1}}	\N
6512844	6512688	c.1129-5923C>G/c.1371C>T	{"DPYD": {"c.1371C>T": 1, "c.1129-5923C>G": 1}}	\N
6512845	6512688	c.1129-5923C>G/c.2978T>G	{"DPYD": {"c.2978T>G": 1, "c.1129-5923C>G": 1}}	\N
6512846	6512688	c.1627A>G (*5)/c.2846A>T	{"DPYD": {"c.2846A>T": 1, "c.1627A>G (*5)": 1}}	\N
6512847	6512688	c.557A>G/c.2921A>T	{"DPYD": {"c.557A>G": 1, "c.2921A>T": 1}}	\N
6512848	6512688	c.1682G>T/c.2846A>T	{"DPYD": {"c.1682G>T": 1, "c.2846A>T": 1}}	\N
6512849	6512688	c.496A>G/c.1129-5923C>G, c.1236G>A (HapB3)	{"DPYD": {"c.496A>G": 1, "c.1129-5923C>G, c.1236G>A (HapB3)": 1}}	\N
6512850	6512688	c.868A>G/c.1905C>G	{"DPYD": {"c.868A>G": 1, "c.1905C>G": 1}}	\N
6512851	6512688	c.868A>G/c.2623A>C	{"DPYD": {"c.868A>G": 1, "c.2623A>C": 1}}	\N
6512852	6512688	c.1129-5923C>G, c.1236G>A (HapB3)/c.1519G>A	{"DPYD": {"c.1519G>A": 1, "c.1129-5923C>G, c.1236G>A (HapB3)": 1}}	\N
6512853	6512688	c.557A>G/c.1294G>A	{"DPYD": {"c.557A>G": 1, "c.1294G>A": 1}}	\N
6512854	6512688	c.557A>G/c.2482G>A	{"DPYD": {"c.557A>G": 1, "c.2482G>A": 1}}	\N
6512855	6512688	c.1180C>T/c.2279C>T	{"DPYD": {"c.1180C>T": 1, "c.2279C>T": 1}}	\N
6512856	6512688	c.313G>A/c.557A>G	{"DPYD": {"c.313G>A": 1, "c.557A>G": 1}}	\N
6512857	6512688	c.313G>A/c.1314T>G	{"DPYD": {"c.313G>A": 1, "c.1314T>G": 1}}	\N
6512858	6512688	c.1577C>G/c.2846A>T	{"DPYD": {"c.1577C>G": 1, "c.2846A>T": 1}}	\N
6512859	6512688	c.557A>G/c.2582A>G	{"DPYD": {"c.557A>G": 1, "c.2582A>G": 1}}	\N
6512860	6512688	c.1129-5923C>G, c.1236G>A (HapB3)/c.2921A>T	{"DPYD": {"c.2921A>T": 1, "c.1129-5923C>G, c.1236G>A (HapB3)": 1}}	\N
6512861	6512688	c.868A>G/c.2915A>G	{"DPYD": {"c.868A>G": 1, "c.2915A>G": 1}}	\N
6512862	6512688	c.2279C>T/c.2623A>C	{"DPYD": {"c.2279C>T": 1, "c.2623A>C": 1}}	\N
6512863	6512688	c.496A>G/c.557A>G	{"DPYD": {"c.496A>G": 1, "c.557A>G": 1}}	\N
6512864	6512688	c.868A>G/c.1577C>G	{"DPYD": {"c.868A>G": 1, "c.1577C>G": 1}}	\N
6512865	6512688	c.46C>G/c.2846A>T	{"DPYD": {"c.46C>G": 1, "c.2846A>T": 1}}	\N
6512866	6512688	c.1129-5923C>G, c.1236G>A (HapB3)/c.1294G>A	{"DPYD": {"c.1294G>A": 1, "c.1129-5923C>G, c.1236G>A (HapB3)": 1}}	\N
6512867	6512688	c.1314T>G/c.1682G>T	{"DPYD": {"c.1314T>G": 1, "c.1682G>T": 1}}	\N
6512868	6512688	c.557A>G/c.1519G>A	{"DPYD": {"c.557A>G": 1, "c.1519G>A": 1}}	\N
6512869	6512688	c.868A>G/c.2161G>A	{"DPYD": {"c.868A>G": 1, "c.2161G>A": 1}}	\N
6512870	6512688	c.1314T>G/c.1627A>G (*5)	{"DPYD": {"c.1314T>G": 1, "c.1627A>G (*5)": 1}}	\N
6512871	6512688	c.1314T>G/c.1615G>A	{"DPYD": {"c.1314T>G": 1, "c.1615G>A": 1}}	\N
6512872	6512688	c.2195T>G/c.2846A>T	{"DPYD": {"c.2195T>G": 1, "c.2846A>T": 1}}	\N
6512873	6512688	c.1371C>T/c.2846A>T	{"DPYD": {"c.1371C>T": 1, "c.2846A>T": 1}}	\N
6512874	6512688	c.967G>A/c.1129-5923C>G	{"DPYD": {"c.967G>A": 1, "c.1129-5923C>G": 1}}	\N
6512875	6512688	c.496A>G/c.1314T>G	{"DPYD": {"c.496A>G": 1, "c.1314T>G": 1}}	\N
6512876	6512688	c.496A>G/c.2846A>T	{"DPYD": {"c.496A>G": 1, "c.2846A>T": 1}}	\N
6512877	6512688	c.1358C>G/c.2279C>T	{"DPYD": {"c.1358C>G": 1, "c.2279C>T": 1}}	\N
6512878	6512688	c.1314T>G/c.1601G>A (*4)	{"DPYD": {"c.1314T>G": 1, "c.1601G>A (*4)": 1}}	\N
6512879	6512688	c.1129-5923C>G/c.1896T>C	{"DPYD": {"c.1896T>C": 1, "c.1129-5923C>G": 1}}	\N
6512880	6512688	c.1129-5923C>G/c.2977C>T	{"DPYD": {"c.2977C>T": 1, "c.1129-5923C>G": 1}}	\N
6512881	6512688	c.1314T>G/c.1796T>C	{"DPYD": {"c.1314T>G": 1, "c.1796T>C": 1}}	\N
6512882	6512688	c.2846A>T/c.3067C>A	{"DPYD": {"c.2846A>T": 1, "c.3067C>A": 1}}	\N
6512883	6512688	c.451A>G/c.868A>G	{"DPYD": {"c.451A>G": 1, "c.868A>G": 1}}	\N
6512884	6512688	c.934C>T/c.1314T>G	{"DPYD": {"c.934C>T": 1, "c.1314T>G": 1}}	\N
6512885	6512688	c.1543G>A/c.2279C>T	{"DPYD": {"c.1543G>A": 1, "c.2279C>T": 1}}	\N
6512886	6512688	c.868A>G/c.2336C>A	{"DPYD": {"c.868A>G": 1, "c.2336C>A": 1}}	\N
6512887	6512688	c.46C>G/c.557A>G	{"DPYD": {"c.46C>G": 1, "c.557A>G": 1}}	\N
6512888	6512688	c.46C>G/c.1314T>G	{"DPYD": {"c.46C>G": 1, "c.1314T>G": 1}}	\N
6512889	6512688	c.1314T>G/c.2303C>A	{"DPYD": {"c.1314T>G": 1, "c.2303C>A": 1}}	\N
6512890	6512688	c.557A>G/c.1358C>G	{"DPYD": {"c.557A>G": 1, "c.1358C>G": 1}}	\N
6512891	6512688	c.557A>G/c.1682G>T	{"DPYD": {"c.557A>G": 1, "c.1682G>T": 1}}	\N
6512892	6512688	c.1314T>G/c.1896T>C	{"DPYD": {"c.1314T>G": 1, "c.1896T>C": 1}}	\N
6512893	6512688	c.1990G>T/c.2279C>T	{"DPYD": {"c.1990G>T": 1, "c.2279C>T": 1}}	\N
6512894	6512688	c.1601G>A (*4)/c.2279C>T	{"DPYD": {"c.2279C>T": 1, "c.1601G>A (*4)": 1}}	\N
6512895	6512688	c.1519G>A/c.2279C>T	{"DPYD": {"c.1519G>A": 1, "c.2279C>T": 1}}	\N
6512896	6512688	c.2656C>T/c.2846A>T	{"DPYD": {"c.2656C>T": 1, "c.2846A>T": 1}}	\N
6512897	6512688	c.1314T>G/c.1519G>A	{"DPYD": {"c.1314T>G": 1, "c.1519G>A": 1}}	\N
6512898	6512688	c.1314T>G/c.1990G>T	{"DPYD": {"c.1314T>G": 1, "c.1990G>T": 1}}	\N
6512899	6512688	c.1314T>G/c.2921A>T	{"DPYD": {"c.1314T>G": 1, "c.2921A>T": 1}}	\N
6512900	6512688	c.775A>G/c.1314T>G	{"DPYD": {"c.775A>G": 1, "c.1314T>G": 1}}	\N
6512901	6512688	c.2279C>T/c.2336C>A	{"DPYD": {"c.2279C>T": 1, "c.2336C>A": 1}}	\N
6512902	6512688	c.868A>G/c.2978T>G	{"DPYD": {"c.868A>G": 1, "c.2978T>G": 1}}	\N
6512903	6512688	c.557A>G/c.1906A>C	{"DPYD": {"c.557A>G": 1, "c.1906A>C": 1}}	\N
6512904	6512688	c.868A>G/c.2977C>T	{"DPYD": {"c.868A>G": 1, "c.2977C>T": 1}}	\N
6512905	6512688	c.1129-5923C>G/c.2336C>A	{"DPYD": {"c.2336C>A": 1, "c.1129-5923C>G": 1}}	\N
6512906	6512688	c.1314T>G/Reference	{"DPYD": {"Reference": 1, "c.1314T>G": 1}}	\N
6512907	6512688	c.1129-5923C>G/c.2303C>A	{"DPYD": {"c.2303C>A": 1, "c.1129-5923C>G": 1}}	\N
6512908	6512688	c.2279C>T/c.2656C>T	{"DPYD": {"c.2279C>T": 1, "c.2656C>T": 1}}	\N
6512909	6512688	c.343A>G/c.1129-5923C>G	{"DPYD": {"c.343A>G": 1, "c.1129-5923C>G": 1}}	\N
6512910	6512688	c.868A>G/c.1003G>T (*11)	{"DPYD": {"c.868A>G": 1, "c.1003G>T (*11)": 1}}	\N
6512911	6512688	c.557A>G/c.3061G>C	{"DPYD": {"c.557A>G": 1, "c.3061G>C": 1}}	\N
6512912	6512688	c.1314T>G/c.1543G>A	{"DPYD": {"c.1314T>G": 1, "c.1543G>A": 1}}	\N
6512913	6512688	c.1129-5923C>G, c.1236G>A (HapB3)/c.1260T>A	{"DPYD": {"c.1260T>A": 1, "c.1129-5923C>G, c.1236G>A (HapB3)": 1}}	\N
6512914	6512688	c.1905C>G/c.2279C>T	{"DPYD": {"c.1905C>G": 1, "c.2279C>T": 1}}	\N
6512915	6512688	c.868A>G/c.1278G>T	{"DPYD": {"c.868A>G": 1, "c.1278G>T": 1}}	\N
6512916	6512688	c.1314T>G/c.1905C>G	{"DPYD": {"c.1314T>G": 1, "c.1905C>G": 1}}	\N
6512917	6512688	c.1314T>G/c.2623A>C	{"DPYD": {"c.1314T>G": 1, "c.2623A>C": 1}}	\N
6512918	6512688	c.1129-5923C>G, c.1236G>A (HapB3)/c.1180C>T	{"DPYD": {"c.1180C>T": 1, "c.1129-5923C>G, c.1236G>A (HapB3)": 1}}	\N
6512919	6512688	c.1181G>T/c.2846A>T	{"DPYD": {"c.1181G>T": 1, "c.2846A>T": 1}}	\N
6512920	6512688	c.1129-5923C>G/c.3067C>A	{"DPYD": {"c.3067C>A": 1, "c.1129-5923C>G": 1}}	\N
6512921	6512688	c.1003G>T (*11)/c.1129-5923C>G, c.1236G>A (HapB3)	{"DPYD": {"c.1003G>T (*11)": 1, "c.1129-5923C>G, c.1236G>A (HapB3)": 1}}	\N
6512922	6512688	c.557A>G/c.3049G>A	{"DPYD": {"c.557A>G": 1, "c.3049G>A": 1}}	\N
6512923	6512688	c.2279C>T/c.3067C>A	{"DPYD": {"c.2279C>T": 1, "c.3067C>A": 1}}	\N
6512924	6512688	c.343A>G/c.2846A>T	{"DPYD": {"c.343A>G": 1, "c.2846A>T": 1}}	\N
6512925	6512688	c.62G>A/c.1129-5923C>G, c.1236G>A (HapB3)	{"DPYD": {"c.62G>A": 1, "c.1129-5923C>G, c.1236G>A (HapB3)": 1}}	\N
6512926	6512688	c.557A>G/c.2194G>A (*6)	{"DPYD": {"c.557A>G": 1, "c.2194G>A (*6)": 1}}	\N
6512927	6512688	c.46C>G/c.868A>G	{"DPYD": {"c.46C>G": 1, "c.868A>G": 1}}	\N
6512928	6512688	c.2846A>T/c.3061G>C	{"DPYD": {"c.2846A>T": 1, "c.3061G>C": 1}}	\N
6512929	6512688	c.1615G>A/c.2279C>T	{"DPYD": {"c.1615G>A": 1, "c.2279C>T": 1}}	\N
6512930	6512688	c.1896T>C/c.2846A>T	{"DPYD": {"c.1896T>C": 1, "c.2846A>T": 1}}	\N
6512931	6512688	c.496A>G/c.2279C>T	{"DPYD": {"c.496A>G": 1, "c.2279C>T": 1}}	\N
6512932	6512688	c.343A>G/c.868A>G	{"DPYD": {"c.343A>G": 1, "c.868A>G": 1}}	\N
6512933	6512688	c.1314T>G/c.3061G>C	{"DPYD": {"c.1314T>G": 1, "c.3061G>C": 1}}	\N
6512934	6512688	c.2846A>T/c.3049G>A	{"DPYD": {"c.2846A>T": 1, "c.3049G>A": 1}}	\N
6512935	6512688	c.868A>G/c.2303C>A	{"DPYD": {"c.868A>G": 1, "c.2303C>A": 1}}	\N
6512936	6512688	c.451A>G/c.1129-5923C>G, c.1236G>A (HapB3)	{"DPYD": {"c.451A>G": 1, "c.1129-5923C>G, c.1236G>A (HapB3)": 1}}	\N
6512937	6512688	c.498G>A/c.2846A>T	{"DPYD": {"c.498G>A": 1, "c.2846A>T": 1}}	\N
6512938	6512688	c.1129-5923C>G, c.1236G>A (HapB3)/c.1218G>A	{"DPYD": {"c.1218G>A": 1, "c.1129-5923C>G, c.1236G>A (HapB3)": 1}}	\N
6512939	6512688	c.1129-5923C>G/c.1519G>A	{"DPYD": {"c.1519G>A": 1, "c.1129-5923C>G": 1}}	\N
6512940	6512688	c.1129-5923C>G/c.1990G>T	{"DPYD": {"c.1990G>T": 1, "c.1129-5923C>G": 1}}	\N
6512941	6512688	c.868A>G/c.1218G>A	{"DPYD": {"c.868A>G": 1, "c.1218G>A": 1}}	\N
6512942	6512688	c.525G>A/c.2279C>T	{"DPYD": {"c.525G>A": 1, "c.2279C>T": 1}}	\N
6512943	6512688	c.46C>G/c.1129-5923C>G	{"DPYD": {"c.46C>G": 1, "c.1129-5923C>G": 1}}	\N
6512944	6512688	c.775A>G/c.868A>G	{"DPYD": {"c.775A>G": 1, "c.868A>G": 1}}	\N
6512945	6512688	c.557A>G/c.934C>T	{"DPYD": {"c.557A>G": 1, "c.934C>T": 1}}	\N
6512946	6512688	c.1129-5923C>G/Reference	{"DPYD": {"Reference": 1, "c.1129-5923C>G": 1}}	\N
6512947	6512688	c.1129-5923C>G/c.1543G>A	{"DPYD": {"c.1543G>A": 1, "c.1129-5923C>G": 1}}	\N
6512948	6512688	c.868A>G/c.3067C>A	{"DPYD": {"c.868A>G": 1, "c.3067C>A": 1}}	\N
6512949	6512688	c.313G>A/c.1129-5923C>G	{"DPYD": {"c.313G>A": 1, "c.1129-5923C>G": 1}}	\N
6512950	6512688	c.557A>G/c.1896T>C	{"DPYD": {"c.557A>G": 1, "c.1896T>C": 1}}	\N
6512951	6512688	c.1129-5923C>G, c.1236G>A (HapB3)/c.1181G>T	{"DPYD": {"c.1181G>T": 1, "c.1129-5923C>G, c.1236G>A (HapB3)": 1}}	\N
6512952	6512688	c.557A>G/c.1371C>T	{"DPYD": {"c.557A>G": 1, "c.1371C>T": 1}}	\N
6512953	6512688	c.557A>G/c.1615G>A	{"DPYD": {"c.557A>G": 1, "c.1615G>A": 1}}	\N
6512954	6512688	c.868A>G/c.1990G>T	{"DPYD": {"c.868A>G": 1, "c.1990G>T": 1}}	\N
6512955	6512688	c.1349C>T/c.2279C>T	{"DPYD": {"c.1349C>T": 1, "c.2279C>T": 1}}	\N
6512956	6512688	c.85T>C (*9A)/c.2846A>T	{"DPYD": {"c.2846A>T": 1, "c.85T>C (*9A)": 1}}	\N
6512957	6512688	c.929T>C/c.2279C>T	{"DPYD": {"c.929T>C": 1, "c.2279C>T": 1}}	\N
6512958	6512688	c.313G>A/c.868A>G	{"DPYD": {"c.313G>A": 1, "c.868A>G": 1}}	\N
6512959	6512688	c.934C>T/c.1129-5923C>G	{"DPYD": {"c.934C>T": 1, "c.1129-5923C>G": 1}}	\N
6512960	6512688	c.1129-5923C>G, c.1236G>A (HapB3)/c.2195T>G	{"DPYD": {"c.2195T>G": 1, "c.1129-5923C>G, c.1236G>A (HapB3)": 1}}	\N
6512961	6512688	c.1129-5923C>G, c.1236G>A (HapB3)/c.2657G>A (*9B)	{"DPYD": {"c.2657G>A (*9B)": 1, "c.1129-5923C>G, c.1236G>A (HapB3)": 1}}	\N
6512962	6512688	c.2336C>A/c.2846A>T	{"DPYD": {"c.2336C>A": 1, "c.2846A>T": 1}}	\N
6512963	6512688	c.1129-5923C>G, c.1236G>A (HapB3)/c.2656C>T	{"DPYD": {"c.2656C>T": 1, "c.1129-5923C>G, c.1236G>A (HapB3)": 1}}	\N
6512964	6512688	c.1682G>T/c.2279C>T	{"DPYD": {"c.1682G>T": 1, "c.2279C>T": 1}}	\N
6512965	6512688	c.2846A>T/c.2921A>T	{"DPYD": {"c.2846A>T": 1, "c.2921A>T": 1}}	\N
6512966	6512688	c.929T>C/c.1129-5923C>G	{"DPYD": {"c.929T>C": 1, "c.1129-5923C>G": 1}}	\N
6512967	6512688	c.868A>G/c.2656C>T	{"DPYD": {"c.868A>G": 1, "c.2656C>T": 1}}	\N
6512968	6512688	c.868A>G/c.1543G>A	{"DPYD": {"c.868A>G": 1, "c.1543G>A": 1}}	\N
6512969	6512688	c.1129-5923C>G, c.1236G>A (HapB3)/c.1627A>G (*5)	{"DPYD": {"c.1627A>G (*5)": 1, "c.1129-5923C>G, c.1236G>A (HapB3)": 1}}	\N
6512970	6512688	c.1129-5923C>G/c.1278G>T	{"DPYD": {"c.1278G>T": 1, "c.1129-5923C>G": 1}}	\N
6512971	6512688	c.1129-5923C>G, c.1236G>A (HapB3)/c.1615G>A	{"DPYD": {"c.1615G>A": 1, "c.1129-5923C>G, c.1236G>A (HapB3)": 1}}	\N
6512972	6512688	c.557A>G/c.1796T>C	{"DPYD": {"c.557A>G": 1, "c.1796T>C": 1}}	\N
6512973	6512688	c.557A>G/c.1601G>A (*4)	{"DPYD": {"c.557A>G": 1, "c.1601G>A (*4)": 1}}	\N
6512974	6512688	c.557A>G/c.1403C>A	{"DPYD": {"c.557A>G": 1, "c.1403C>A": 1}}	\N
6512975	6512688	c.1129-5923C>G/c.1682G>T	{"DPYD": {"c.1682G>T": 1, "c.1129-5923C>G": 1}}	\N
6512976	6512688	c.343A>G/c.557A>G	{"DPYD": {"c.343A>G": 1, "c.557A>G": 1}}	\N
6512977	6512688	c.2161G>A/c.2846A>T	{"DPYD": {"c.2161G>A": 1, "c.2846A>T": 1}}	\N
6512978	6512688	c.967G>A/c.2846A>T	{"DPYD": {"c.967G>A": 1, "c.2846A>T": 1}}	\N
6512979	6512688	c.1129-5923C>G/c.1601G>A (*4)	{"DPYD": {"c.1129-5923C>G": 1, "c.1601G>A (*4)": 1}}	\N
6512980	6512688	c.557A>G/c.1278G>T	{"DPYD": {"c.557A>G": 1, "c.1278G>T": 1}}	\N
6512981	6512688	c.934C>T/c.1129-5923C>G, c.1236G>A (HapB3)	{"DPYD": {"c.934C>T": 1, "c.1129-5923C>G, c.1236G>A (HapB3)": 1}}	\N
6512982	6512688	c.525G>A/c.1129-5923C>G	{"DPYD": {"c.525G>A": 1, "c.1129-5923C>G": 1}}	\N
6512983	6512688	c.1314T>G/c.2194G>A (*6)	{"DPYD": {"c.1314T>G": 1, "c.2194G>A (*6)": 1}}	\N
6512984	6512688	c.343A>G/c.1314T>G	{"DPYD": {"c.343A>G": 1, "c.1314T>G": 1}}	\N
6512985	6512688	c.868A>G/c.934C>T	{"DPYD": {"c.868A>G": 1, "c.934C>T": 1}}	\N
6512986	6512688	c.557A>G/c.3067C>A	{"DPYD": {"c.557A>G": 1, "c.3067C>A": 1}}	\N
6512987	6512688	c.1314T>G/c.2186C>T	{"DPYD": {"c.1314T>G": 1, "c.2186C>T": 1}}	\N
6512988	6512688	c.557A>G/c.1905C>G	{"DPYD": {"c.557A>G": 1, "c.1905C>G": 1}}	\N
6512989	6512688	c.496A>G/c.1129-5923C>G	{"DPYD": {"c.496A>G": 1, "c.1129-5923C>G": 1}}	\N
6512990	6512688	c.85T>C (*9A)/c.1129-5923C>G	{"DPYD": {"c.85T>C (*9A)": 1, "c.1129-5923C>G": 1}}	\N
6512991	6512688	c.868A>G/Reference	{"DPYD": {"c.868A>G": 1, "Reference": 1}}	\N
6512992	6512688	c.557A>G/c.1003G>T (*11)	{"DPYD": {"c.557A>G": 1, "c.1003G>T (*11)": 1}}	\N
6512993	6512688	c.2846A>T/c.2915A>G	{"DPYD": {"c.2846A>T": 1, "c.2915A>G": 1}}	\N
6512994	6512688	c.1129-5923C>G/c.1403C>A	{"DPYD": {"c.1403C>A": 1, "c.1129-5923C>G": 1}}	\N
6512995	6512688	c.1314T>G/c.2977C>T	{"DPYD": {"c.1314T>G": 1, "c.2977C>T": 1}}	\N
6512996	6512688	c.557A>G/c.2303C>A	{"DPYD": {"c.557A>G": 1, "c.2303C>A": 1}}	\N
6512997	6512688	c.557A>G/c.2195T>G	{"DPYD": {"c.557A>G": 1, "c.2195T>G": 1}}	\N
6512998	6512688	c.1129-5923C>G, c.1236G>A (HapB3)/c.2336C>A	{"DPYD": {"c.2336C>A": 1, "c.1129-5923C>G, c.1236G>A (HapB3)": 1}}	\N
6512999	6512688	c.557A>G/c.2657G>A (*9B)	{"DPYD": {"c.557A>G": 1, "c.2657G>A (*9B)": 1}}	\N
6513000	6512688	c.525G>A/c.2846A>T	{"DPYD": {"c.525G>A": 1, "c.2846A>T": 1}}	\N
6513001	6512688	c.1278G>T/c.1314T>G	{"DPYD": {"c.1278G>T": 1, "c.1314T>G": 1}}	\N
6513002	6512688	c.2279C>T/c.3061G>C	{"DPYD": {"c.2279C>T": 1, "c.3061G>C": 1}}	\N
6513003	6512688	c.868A>G/c.1108A>G	{"DPYD": {"c.868A>G": 1, "c.1108A>G": 1}}	\N
6513004	6512688	c.775A>G/c.1129-5923C>G	{"DPYD": {"c.775A>G": 1, "c.1129-5923C>G": 1}}	\N
6513005	6512688	c.2846A>T/Reference	{"DPYD": {"Reference": 1, "c.2846A>T": 1}}	\N
6513006	6512688	c.1314T>G/c.1358C>G	{"DPYD": {"c.1314T>G": 1, "c.1358C>G": 1}}	\N
6513007	6512688	c.868A>G/c.1519G>A	{"DPYD": {"c.868A>G": 1, "c.1519G>A": 1}}	\N
6513008	6512688	c.1129-5923C>G/c.1627A>G (*5)	{"DPYD": {"c.1129-5923C>G": 1, "c.1627A>G (*5)": 1}}	\N
6513009	6512688	c.1314T>G/c.2978T>G	{"DPYD": {"c.1314T>G": 1, "c.2978T>G": 1}}	\N
6513010	6512688	c.557A>G/c.2623A>C	{"DPYD": {"c.557A>G": 1, "c.2623A>C": 1}}	\N
6513011	6512688	c.62G>A/c.868A>G	{"DPYD": {"c.62G>A": 1, "c.868A>G": 1}}	\N
6513012	6512688	c.1314T>G/c.1906A>C	{"DPYD": {"c.1314T>G": 1, "c.1906A>C": 1}}	\N
6513013	6512688	c.1349C>T/c.2846A>T	{"DPYD": {"c.1349C>T": 1, "c.2846A>T": 1}}	\N
6513014	6512688	c.1129-5923C>G, c.1236G>A (HapB3)/c.1278G>T	{"DPYD": {"c.1278G>T": 1, "c.1129-5923C>G, c.1236G>A (HapB3)": 1}}	\N
6513015	6512688	c.1358C>G/c.2846A>T	{"DPYD": {"c.1358C>G": 1, "c.2846A>T": 1}}	\N
6513016	6512688	c.1180C>T/c.2846A>T	{"DPYD": {"c.1180C>T": 1, "c.2846A>T": 1}}	\N
6513017	6512688	c.557A>G/c.2915A>G	{"DPYD": {"c.557A>G": 1, "c.2915A>G": 1}}	\N
6513018	6512688	c.2279C>T/c.2921A>T	{"DPYD": {"c.2279C>T": 1, "c.2921A>T": 1}}	\N
6513019	6512688	c.557A>G/c.1990G>T	{"DPYD": {"c.557A>G": 1, "c.1990G>T": 1}}	\N
6513020	6512688	c.1294G>A/c.1314T>G	{"DPYD": {"c.1294G>A": 1, "c.1314T>G": 1}}	\N
6513021	6512688	c.868A>G/c.1896T>C	{"DPYD": {"c.868A>G": 1, "c.1896T>C": 1}}	\N
6513022	6512688	c.2279C>T/c.2303C>A	{"DPYD": {"c.2279C>T": 1, "c.2303C>A": 1}}	\N
6513023	6512688	c.1314T>G/c.3049G>A	{"DPYD": {"c.1314T>G": 1, "c.3049G>A": 1}}	\N
6513024	6512688	c.1129-5923C>G/c.2161G>A	{"DPYD": {"c.2161G>A": 1, "c.1129-5923C>G": 1}}	\N
6513025	6512688	c.85T>C (*9A)/c.2279C>T	{"DPYD": {"c.2279C>T": 1, "c.85T>C (*9A)": 1}}	\N
6513026	6512688	c.1129-5923C>G/c.1577C>G	{"DPYD": {"c.1577C>G": 1, "c.1129-5923C>G": 1}}	\N
6513027	6512688	c.1129-5923C>G/c.2656C>T	{"DPYD": {"c.2656C>T": 1, "c.1129-5923C>G": 1}}	\N
6513028	6512688	c.1129-5923C>G/c.1218G>A	{"DPYD": {"c.1218G>A": 1, "c.1129-5923C>G": 1}}	\N
6513029	6512688	c.1129-5923C>G, c.1236G>A (HapB3)/c.1905C>G	{"DPYD": {"c.1905C>G": 1, "c.1129-5923C>G, c.1236G>A (HapB3)": 1}}	\N
6513030	6512688	c.868A>G/c.2186C>T	{"DPYD": {"c.868A>G": 1, "c.2186C>T": 1}}	\N
6513031	6512688	c.1129-5923C>G/c.2915A>G	{"DPYD": {"c.2915A>G": 1, "c.1129-5923C>G": 1}}	\N
6513032	6512688	c.1403C>A/c.2279C>T	{"DPYD": {"c.1403C>A": 1, "c.2279C>T": 1}}	\N
6513033	6512688	c.1129-5923C>G/c.2623A>C	{"DPYD": {"c.2623A>C": 1, "c.1129-5923C>G": 1}}	\N
6513034	6512688	c.1294G>A/c.2846A>T	{"DPYD": {"c.1294G>A": 1, "c.2846A>T": 1}}	\N
6513035	6512688	c.1108A>G/c.1129-5923C>G, c.1236G>A (HapB3)	{"DPYD": {"c.1108A>G": 1, "c.1129-5923C>G, c.1236G>A (HapB3)": 1}}	\N
6513036	6512688	c.1314T>G/c.2336C>A	{"DPYD": {"c.1314T>G": 1, "c.2336C>A": 1}}	\N
6513037	6512688	c.557A>G/c.775A>G	{"DPYD": {"c.557A>G": 1, "c.775A>G": 1}}	\N
6513038	6512688	c.2186C>T/c.2279C>T	{"DPYD": {"c.2186C>T": 1, "c.2279C>T": 1}}	\N
6513039	6512688	c.451A>G/c.2279C>T	{"DPYD": {"c.451A>G": 1, "c.2279C>T": 1}}	\N
6513040	6512688	c.1129-5923C>G, c.1236G>A (HapB3)/c.1577C>G	{"DPYD": {"c.1577C>G": 1, "c.1129-5923C>G, c.1236G>A (HapB3)": 1}}	\N
6513041	6512688	c.1003G>T (*11)/c.2846A>T	{"DPYD": {"c.2846A>T": 1, "c.1003G>T (*11)": 1}}	\N
6513042	6512688	c.1129-5923C>G/c.1796T>C	{"DPYD": {"c.1796T>C": 1, "c.1129-5923C>G": 1}}	\N
6513043	6512688	c.1314T>G/c.1349C>T	{"DPYD": {"c.1314T>G": 1, "c.1349C>T": 1}}	\N
6513044	6512688	c.1129-5923C>G, c.1236G>A (HapB3)/c.2915A>G	{"DPYD": {"c.2915A>G": 1, "c.1129-5923C>G, c.1236G>A (HapB3)": 1}}	\N
6513045	6512688	c.929T>C/c.2846A>T	{"DPYD": {"c.929T>C": 1, "c.2846A>T": 1}}	\N
6513046	6512688	c.557A>G/c.2161G>A	{"DPYD": {"c.557A>G": 1, "c.2161G>A": 1}}	\N
6513047	6512688	c.929T>C/c.1314T>G	{"DPYD": {"c.929T>C": 1, "c.1314T>G": 1}}	\N
6513048	6512688	c.498G>A/c.1129-5923C>G	{"DPYD": {"c.498G>A": 1, "c.1129-5923C>G": 1}}	\N
6513049	6512688	c.1003G>T (*11)/c.1314T>G	{"DPYD": {"c.1314T>G": 1, "c.1003G>T (*11)": 1}}	\N
6513050	6512688	c.557A>G/c.1577C>G	{"DPYD": {"c.557A>G": 1, "c.1577C>G": 1}}	\N
6513051	6512688	c.1314T>G/c.2657G>A (*9B)	{"DPYD": {"c.1314T>G": 1, "c.2657G>A (*9B)": 1}}	\N
6513052	6512688	c.1314T>G/c.3067C>A	{"DPYD": {"c.1314T>G": 1, "c.3067C>A": 1}}	\N
6513053	6512688	c.1314T>G/c.2195T>G	{"DPYD": {"c.1314T>G": 1, "c.2195T>G": 1}}	\N
6513054	6512688	c.868A>G/c.1294G>A	{"DPYD": {"c.868A>G": 1, "c.1294G>A": 1}}	\N
6513055	6512688	c.934C>T/c.2846A>T	{"DPYD": {"c.934C>T": 1, "c.2846A>T": 1}}	\N
6513056	6512688	c.1278G>T/c.2846A>T	{"DPYD": {"c.1278G>T": 1, "c.2846A>T": 1}}	\N
6513057	6512688	c.1260T>A/c.2846A>T	{"DPYD": {"c.1260T>A": 1, "c.2846A>T": 1}}	\N
6513058	6512688	c.868A>G/c.3049G>A	{"DPYD": {"c.868A>G": 1, "c.3049G>A": 1}}	\N
6513059	6512688	c.868A>G/c.2921A>T	{"DPYD": {"c.868A>G": 1, "c.2921A>T": 1}}	\N
6513060	6512688	c.2279C>T/c.2977C>T	{"DPYD": {"c.2279C>T": 1, "c.2977C>T": 1}}	\N
6513061	6512688	c.1129-5923C>G/c.1180C>T	{"DPYD": {"c.1180C>T": 1, "c.1129-5923C>G": 1}}	\N
6513062	6512688	c.525G>A/c.1314T>G	{"DPYD": {"c.525G>A": 1, "c.1314T>G": 1}}	\N
6513063	6512688	c.1129-5923C>G/c.1905C>G	{"DPYD": {"c.1905C>G": 1, "c.1129-5923C>G": 1}}	\N
6513064	6512688	c.2279C>T/c.3049G>A	{"DPYD": {"c.2279C>T": 1, "c.3049G>A": 1}}	\N
6513065	6512688	c.1129-5923C>G, c.1236G>A (HapB3)/c.2161G>A	{"DPYD": {"c.2161G>A": 1, "c.1129-5923C>G, c.1236G>A (HapB3)": 1}}	\N
6513066	6512688	c.868A>G/c.3061G>C	{"DPYD": {"c.868A>G": 1, "c.3061G>C": 1}}	\N
6513067	6512688	c.1314T>G/c.1371C>T	{"DPYD": {"c.1314T>G": 1, "c.1371C>T": 1}}	\N
6513068	6512688	c.1108A>G/c.2846A>T	{"DPYD": {"c.1108A>G": 1, "c.2846A>T": 1}}	\N
6513069	6512688	c.2482G>A/c.2846A>T	{"DPYD": {"c.2482G>A": 1, "c.2846A>T": 1}}	\N
6513070	6512688	c.1218G>A/c.2846A>T	{"DPYD": {"c.1218G>A": 1, "c.2846A>T": 1}}	\N
6513071	6512688	c.498G>A/c.2279C>T	{"DPYD": {"c.498G>A": 1, "c.2279C>T": 1}}	\N
6513072	6512688	c.1519G>A/c.2846A>T	{"DPYD": {"c.1519G>A": 1, "c.2846A>T": 1}}	\N
6513073	6512688	c.525G>A/c.1129-5923C>G, c.1236G>A (HapB3)	{"DPYD": {"c.525G>A": 1, "c.1129-5923C>G, c.1236G>A (HapB3)": 1}}	\N
6513074	6512688	c.929T>C/c.1129-5923C>G, c.1236G>A (HapB3)	{"DPYD": {"c.929T>C": 1, "c.1129-5923C>G, c.1236G>A (HapB3)": 1}}	\N
6513075	6512688	c.451A>G/c.1129-5923C>G	{"DPYD": {"c.451A>G": 1, "c.1129-5923C>G": 1}}	\N
6513076	6512688	c.2279C>T/c.2978T>G	{"DPYD": {"c.2279C>T": 1, "c.2978T>G": 1}}	\N
6513077	6512688	c.1260T>A/c.1314T>G	{"DPYD": {"c.1260T>A": 1, "c.1314T>G": 1}}	\N
6513078	6512688	c.525G>A/c.557A>G	{"DPYD": {"c.525G>A": 1, "c.557A>G": 1}}	\N
6513079	6512688	c.1108A>G/c.1314T>G	{"DPYD": {"c.1108A>G": 1, "c.1314T>G": 1}}	\N
6513080	6512688	c.1218G>A/c.1314T>G	{"DPYD": {"c.1218G>A": 1, "c.1314T>G": 1}}	\N
6513083	6513082	c.967G>A/c.1679T>G (*13)	{"DPYD": {"c.967G>A": 1, "c.1679T>G (*13)": 1}}	\N
6513084	6513082	c.1403C>A/c.1484A>G	{"DPYD": {"c.1403C>A": 1, "c.1484A>G": 1}}	\N
6513085	6513082	c.1057C>T/c.3067C>A	{"DPYD": {"c.1057C>T": 1, "c.3067C>A": 1}}	\N
6513086	6513082	c.703C>T (*8)/c.1349C>T	{"DPYD": {"c.1349C>T": 1, "c.703C>T (*8)": 1}}	\N
6513087	6513082	c.1615G>A/c.1679T>G (*13)	{"DPYD": {"c.1615G>A": 1, "c.1679T>G (*13)": 1}}	\N
6513088	6513082	c.61C>T/c.2482G>A	{"DPYD": {"c.61C>T": 1, "c.2482G>A": 1}}	\N
6513089	6513082	c.496A>G/c.1484A>G	{"DPYD": {"c.496A>G": 1, "c.1484A>G": 1}}	\N
6513090	6513082	c.1519G>A/c.2983G>T (*10)	{"DPYD": {"c.1519G>A": 1, "c.2983G>T (*10)": 1}}	\N
6513091	6513082	c.1543G>A/c.2983G>T (*10)	{"DPYD": {"c.1543G>A": 1, "c.2983G>T (*10)": 1}}	\N
6513092	6513082	c.1990G>T/c.2983G>T (*10)	{"DPYD": {"c.1990G>T": 1, "c.2983G>T (*10)": 1}}	\N
6513093	6513082	c.1260T>A/c.2933A>G	{"DPYD": {"c.1260T>A": 1, "c.2933A>G": 1}}	\N
6513094	6513082	c.61C>T/c.1371C>T	{"DPYD": {"c.61C>T": 1, "c.1371C>T": 1}}	\N
6513095	6513082	c.61C>T/c.2161G>A	{"DPYD": {"c.61C>T": 1, "c.2161G>A": 1}}	\N
6513096	6513082	c.1775G>A/c.2161G>A	{"DPYD": {"c.1775G>A": 1, "c.2161G>A": 1}}	\N
6513097	6513082	c.1278G>T/c.2639G>T	{"DPYD": {"c.1278G>T": 1, "c.2639G>T": 1}}	\N
6513098	6513082	c.61C>T/c.1577C>G	{"DPYD": {"c.61C>T": 1, "c.1577C>G": 1}}	\N
6513099	6513082	c.1278G>T/c.1898delC (*3)	{"DPYD": {"c.1278G>T": 1, "c.1898delC (*3)": 1}}	\N
6513100	6513082	c.343A>G/c.2933A>G	{"DPYD": {"c.343A>G": 1, "c.2933A>G": 1}}	\N
6513101	6513082	c.61C>T/c.1796T>C	{"DPYD": {"c.61C>T": 1, "c.1796T>C": 1}}	\N
6513102	6513082	c.451A>G/c.1777G>A	{"DPYD": {"c.451A>G": 1, "c.1777G>A": 1}}	\N
6513103	6513082	c.601A>C/c.2921A>T	{"DPYD": {"c.601A>C": 1, "c.2921A>T": 1}}	\N
6513104	6513082	c.1775G>A/c.2482G>A	{"DPYD": {"c.1775G>A": 1, "c.2482G>A": 1}}	\N
6513105	6513082	c.85T>C (*9A)/c.601A>C	{"DPYD": {"c.601A>C": 1, "c.85T>C (*9A)": 1}}	\N
6513106	6513082	c.46C>G/c.632A>G	{"DPYD": {"c.46C>G": 1, "c.632A>G": 1}}	\N
6513107	6513082	c.934C>T/c.1024G>A	{"DPYD": {"c.934C>T": 1, "c.1024G>A": 1}}	\N
6513108	6513082	c.1260T>A/c.2021G>A	{"DPYD": {"c.1260T>A": 1, "c.2021G>A": 1}}	\N
6513109	6513082	c.601A>C/c.1519G>A	{"DPYD": {"c.601A>C": 1, "c.1519G>A": 1}}	\N
6513110	6513082	c.601A>C/c.1990G>T	{"DPYD": {"c.601A>C": 1, "c.1990G>T": 1}}	\N
6513111	6513082	c.1896T>C/c.2021G>A	{"DPYD": {"c.1896T>C": 1, "c.2021G>A": 1}}	\N
6513112	6513082	c.313G>A/c.1057C>T	{"DPYD": {"c.313G>A": 1, "c.1057C>T": 1}}	\N
6513113	6513082	c.1905+1G>A (*2A)/Reference	{"DPYD": {"Reference": 1, "c.1905+1G>A (*2A)": 1}}	\N
6513114	6513082	c.2021G>A/c.2482G>A	{"DPYD": {"c.2021G>A": 1, "c.2482G>A": 1}}	\N
6513115	6513082	c.632A>G/c.2336C>A	{"DPYD": {"c.632A>G": 1, "c.2336C>A": 1}}	\N
6513116	6513082	c.1024G>A/c.1905C>G	{"DPYD": {"c.1024G>A": 1, "c.1905C>G": 1}}	\N
6513117	6513082	c.295_298delTCAT (*7)/c.2977C>T	{"DPYD": {"c.2977C>T": 1, "c.295_298delTCAT (*7)": 1}}	\N
6513118	6513082	c.1774C>T/c.1905C>G	{"DPYD": {"c.1774C>T": 1, "c.1905C>G": 1}}	\N
6513119	6513082	c.2021G>A/c.2161G>A	{"DPYD": {"c.2021G>A": 1, "c.2161G>A": 1}}	\N
6513120	6513082	c.1156G>T (*12)/c.1371C>T	{"DPYD": {"c.1371C>T": 1, "c.1156G>T (*12)": 1}}	\N
6513121	6513082	c.1156G>T (*12)/c.1358C>G	{"DPYD": {"c.1358C>G": 1, "c.1156G>T (*12)": 1}}	\N
6513122	6513082	c.525G>A/c.1484A>G	{"DPYD": {"c.525G>A": 1, "c.1484A>G": 1}}	\N
6513123	6513082	c.496A>G/c.1775G>A	{"DPYD": {"c.496A>G": 1, "c.1775G>A": 1}}	\N
6513124	6513082	c.601A>C/c.2303C>A	{"DPYD": {"c.601A>C": 1, "c.2303C>A": 1}}	\N
6513125	6513082	c.1682G>T/c.2021G>A	{"DPYD": {"c.1682G>T": 1, "c.2021G>A": 1}}	\N
6513126	6513082	c.1218G>A/c.2933A>G	{"DPYD": {"c.1218G>A": 1, "c.2933A>G": 1}}	\N
6513127	6513082	c.1905+1G>A (*2A)/c.2623A>C	{"DPYD": {"c.2623A>C": 1, "c.1905+1G>A (*2A)": 1}}	\N
6513128	6513082	c.929T>C/c.1484A>G	{"DPYD": {"c.929T>C": 1, "c.1484A>G": 1}}	\N
6513129	6513082	c.1156G>T (*12)/c.1682G>T	{"DPYD": {"c.1682G>T": 1, "c.1156G>T (*12)": 1}}	\N
6513130	6513082	c.1349C>T/c.1679T>G (*13)	{"DPYD": {"c.1349C>T": 1, "c.1679T>G (*13)": 1}}	\N
6513131	6513082	c.295_298delTCAT (*7)/c.2656C>T	{"DPYD": {"c.2656C>T": 1, "c.295_298delTCAT (*7)": 1}}	\N
6513132	6513082	c.2933A>G/c.3067C>A	{"DPYD": {"c.2933A>G": 1, "c.3067C>A": 1}}	\N
6513133	6513082	c.85T>C (*9A)/c.1679T>G (*13)	{"DPYD": {"c.85T>C (*9A)": 1, "c.1679T>G (*13)": 1}}	\N
6513134	6513082	c.1156G>T (*12)/c.1577C>G	{"DPYD": {"c.1577C>G": 1, "c.1156G>T (*12)": 1}}	\N
6513135	6513082	c.2161G>A/c.2872A>G	{"DPYD": {"c.2161G>A": 1, "c.2872A>G": 1}}	\N
6513136	6513082	c.601A>C/c.1403C>A	{"DPYD": {"c.601A>C": 1, "c.1403C>A": 1}}	\N
6513137	6513082	c.967G>A/c.1156G>T (*12)	{"DPYD": {"c.967G>A": 1, "c.1156G>T (*12)": 1}}	\N
6513138	6513082	c.1180C>T/c.1484A>G	{"DPYD": {"c.1180C>T": 1, "c.1484A>G": 1}}	\N
6513139	6513082	c.1156G>T (*12)/c.2161G>A	{"DPYD": {"c.2161G>A": 1, "c.1156G>T (*12)": 1}}	\N
6513140	6513082	c.343A>G/c.2021G>A	{"DPYD": {"c.343A>G": 1, "c.2021G>A": 1}}	\N
6513141	6513082	c.1601G>A (*4)/c.1777G>A	{"DPYD": {"c.1777G>A": 1, "c.1601G>A (*4)": 1}}	\N
6513142	6513082	c.1682G>T/c.2933A>G	{"DPYD": {"c.1682G>T": 1, "c.2933A>G": 1}}	\N
6513143	6513082	c.1057C>T/c.2303C>A	{"DPYD": {"c.1057C>T": 1, "c.2303C>A": 1}}	\N
6513144	6513082	c.1484A>G/c.1627A>G (*5)	{"DPYD": {"c.1484A>G": 1, "c.1627A>G (*5)": 1}}	\N
6513145	6513082	c.1774C>T/c.2336C>A	{"DPYD": {"c.1774C>T": 1, "c.2336C>A": 1}}	\N
6513146	6513082	c.1024G>A/c.1278G>T	{"DPYD": {"c.1024G>A": 1, "c.1278G>T": 1}}	\N
6513147	6513082	c.1543G>A/c.1774C>T	{"DPYD": {"c.1543G>A": 1, "c.1774C>T": 1}}	\N
6513148	6513082	c.1057C>T/c.1990G>T	{"DPYD": {"c.1057C>T": 1, "c.1990G>T": 1}}	\N
6513149	6513082	c.498G>A/c.1484A>G	{"DPYD": {"c.498G>A": 1, "c.1484A>G": 1}}	\N
6513150	6513082	c.62G>A/c.1905+1G>A (*2A)	{"DPYD": {"c.62G>A": 1, "c.1905+1G>A (*2A)": 1}}	\N
6513151	6513082	c.1775G>A/c.1796T>C	{"DPYD": {"c.1775G>A": 1, "c.1796T>C": 1}}	\N
6513152	6513082	c.929T>C/c.2021G>A	{"DPYD": {"c.929T>C": 1, "c.2021G>A": 1}}	\N
6513153	6513082	c.498G>A/c.2021G>A	{"DPYD": {"c.498G>A": 1, "c.2021G>A": 1}}	\N
6513154	6513082	c.1057C>T/c.2921A>T	{"DPYD": {"c.1057C>T": 1, "c.2921A>T": 1}}	\N
6513155	6513082	c.1294G>A/c.1905+1G>A (*2A)	{"DPYD": {"c.1294G>A": 1, "c.1905+1G>A (*2A)": 1}}	\N
6513156	6513082	c.1156G>T (*12)/c.3061G>C	{"DPYD": {"c.3061G>C": 1, "c.1156G>T (*12)": 1}}	\N
6513157	6513082	c.601A>C/c.3067C>A	{"DPYD": {"c.601A>C": 1, "c.3067C>A": 1}}	\N
6513158	6513082	c.61C>T/c.1358C>G	{"DPYD": {"c.61C>T": 1, "c.1358C>G": 1}}	\N
6513159	6513082	c.295_298delTCAT (*7)/c.967G>A	{"DPYD": {"c.967G>A": 1, "c.295_298delTCAT (*7)": 1}}	\N
6513160	6513082	c.61C>T/c.1601G>A (*4)	{"DPYD": {"c.61C>T": 1, "c.1601G>A (*4)": 1}}	\N
6513161	6513082	c.601A>C/c.1906A>C	{"DPYD": {"c.601A>C": 1, "c.1906A>C": 1}}	\N
6513162	6513082	c.1774C>T/Reference	{"DPYD": {"Reference": 1, "c.1774C>T": 1}}	\N
6513163	6513082	c.1905+1G>A (*2A)/c.1905C>G	{"DPYD": {"c.1905C>G": 1, "c.1905+1G>A (*2A)": 1}}	\N
6513164	6513082	c.2021G>A/c.3061G>C	{"DPYD": {"c.2021G>A": 1, "c.3061G>C": 1}}	\N
6513165	6513082	c.967G>A/c.1475C>T	{"DPYD": {"c.967G>A": 1, "c.1475C>T": 1}}	\N
6513166	6513082	c.85T>C (*9A)/c.1156G>T (*12)	{"DPYD": {"c.85T>C (*9A)": 1, "c.1156G>T (*12)": 1}}	\N
6513167	6513082	c.1543G>A/c.1679T>G (*13)	{"DPYD": {"c.1543G>A": 1, "c.1679T>G (*13)": 1}}	\N
6513168	6513082	c.1181G>T/c.2933A>G	{"DPYD": {"c.1181G>T": 1, "c.2933A>G": 1}}	\N
6513169	6513082	c.632A>G/c.2623A>C	{"DPYD": {"c.632A>G": 1, "c.2623A>C": 1}}	\N
6513170	6513082	c.703C>T (*8)/c.1108A>G	{"DPYD": {"c.1108A>G": 1, "c.703C>T (*8)": 1}}	\N
6513171	6513082	c.703C>T (*8)/c.1260T>A	{"DPYD": {"c.1260T>A": 1, "c.703C>T (*8)": 1}}	\N
6513172	6513082	c.525G>A/c.2021G>A	{"DPYD": {"c.525G>A": 1, "c.2021G>A": 1}}	\N
6513173	6513082	c.775A>G/c.1057C>T	{"DPYD": {"c.775A>G": 1, "c.1057C>T": 1}}	\N
6513174	6513082	c.1519G>A/c.1905+1G>A (*2A)	{"DPYD": {"c.1519G>A": 1, "c.1905+1G>A (*2A)": 1}}	\N
6513175	6513082	c.61C>T/c.1615G>A	{"DPYD": {"c.61C>T": 1, "c.1615G>A": 1}}	\N
6513176	6513082	c.498G>A/c.1775G>A	{"DPYD": {"c.498G>A": 1, "c.1775G>A": 1}}	\N
6513177	6513082	c.85T>C (*9A)/c.2639G>T	{"DPYD": {"c.2639G>T": 1, "c.85T>C (*9A)": 1}}	\N
6513178	6513082	c.1003G>T (*11)/c.1905+1G>A (*2A)	{"DPYD": {"c.1003G>T (*11)": 1, "c.1905+1G>A (*2A)": 1}}	\N
6513179	6513082	c.1024G>A/c.1896T>C	{"DPYD": {"c.1024G>A": 1, "c.1896T>C": 1}}	\N
6513180	6513082	c.1156G>T (*12)/Reference	{"DPYD": {"Reference": 1, "c.1156G>T (*12)": 1}}	\N
6513181	6513082	c.1775G>A/c.3061G>C	{"DPYD": {"c.1775G>A": 1, "c.3061G>C": 1}}	\N
6513182	6513082	c.775A>G/c.2872A>G	{"DPYD": {"c.775A>G": 1, "c.2872A>G": 1}}	\N
6513183	6513082	c.1615G>A/c.2639G>T	{"DPYD": {"c.1615G>A": 1, "c.2639G>T": 1}}	\N
6513184	6513082	c.929T>C/c.2933A>G	{"DPYD": {"c.929T>C": 1, "c.2933A>G": 1}}	\N
6513185	6513082	c.1475C>T/c.3067C>A	{"DPYD": {"c.1475C>T": 1, "c.3067C>A": 1}}	\N
6513186	6513082	c.496A>G/c.2021G>A	{"DPYD": {"c.496A>G": 1, "c.2021G>A": 1}}	\N
6513187	6513082	c.1180C>T/c.1775G>A	{"DPYD": {"c.1180C>T": 1, "c.1775G>A": 1}}	\N
6513188	6513082	c.1218G>A/c.2021G>A	{"DPYD": {"c.1218G>A": 1, "c.2021G>A": 1}}	\N
6513189	6513082	c.1906A>C/c.2872A>G	{"DPYD": {"c.1906A>C": 1, "c.2872A>G": 1}}	\N
6513190	6513082	c.1024G>A/c.2623A>C	{"DPYD": {"c.1024G>A": 1, "c.2623A>C": 1}}	\N
6513191	6513082	c.1475C>T/c.2303C>A	{"DPYD": {"c.1475C>T": 1, "c.2303C>A": 1}}	\N
6513192	6513082	c.1294G>A/c.1774C>T	{"DPYD": {"c.1294G>A": 1, "c.1774C>T": 1}}	\N
6513193	6513082	c.1180C>T/c.2021G>A	{"DPYD": {"c.1180C>T": 1, "c.2021G>A": 1}}	\N
6513194	6513082	c.2194G>A (*6)/c.2872A>G	{"DPYD": {"c.2872A>G": 1, "c.2194G>A (*6)": 1}}	\N
6513195	6513082	c.1475C>T/c.2656C>T	{"DPYD": {"c.1475C>T": 1, "c.2656C>T": 1}}	\N
6513196	6513082	c.1543G>A/c.1905+1G>A (*2A)	{"DPYD": {"c.1543G>A": 1, "c.1905+1G>A (*2A)": 1}}	\N
6513197	6513082	c.1024G>A/c.2978T>G	{"DPYD": {"c.1024G>A": 1, "c.2978T>G": 1}}	\N
6513198	6513082	c.1108A>G/c.1905+1G>A (*2A)	{"DPYD": {"c.1108A>G": 1, "c.1905+1G>A (*2A)": 1}}	\N
6513199	6513082	c.601A>C/c.2194G>A (*6)	{"DPYD": {"c.601A>C": 1, "c.2194G>A (*6)": 1}}	\N
6513200	6513082	c.1777G>A/c.2582A>G	{"DPYD": {"c.1777G>A": 1, "c.2582A>G": 1}}	\N
6513201	6513082	c.1003G>T (*11)/c.1774C>T	{"DPYD": {"c.1774C>T": 1, "c.1003G>T (*11)": 1}}	\N
6513202	6513082	c.1371C>T/c.2872A>G	{"DPYD": {"c.1371C>T": 1, "c.2872A>G": 1}}	\N
6513203	6513082	c.1475C>T/c.2977C>T	{"DPYD": {"c.1475C>T": 1, "c.2977C>T": 1}}	\N
6513204	6513082	c.632A>G/c.2978T>G	{"DPYD": {"c.632A>G": 1, "c.2978T>G": 1}}	\N
6513205	6513082	c.1519G>A/c.1774C>T	{"DPYD": {"c.1519G>A": 1, "c.1774C>T": 1}}	\N
6513206	6513082	c.1905+1G>A (*2A)/c.2161G>A	{"DPYD": {"c.2161G>A": 1, "c.1905+1G>A (*2A)": 1}}	\N
6513207	6513082	c.967G>A/c.1898delC (*3)	{"DPYD": {"c.967G>A": 1, "c.1898delC (*3)": 1}}	\N
6513208	6513082	c.1057C>T/c.1403C>A	{"DPYD": {"c.1057C>T": 1, "c.1403C>A": 1}}	\N
6513209	6513082	c.1024G>A/c.2186C>T	{"DPYD": {"c.1024G>A": 1, "c.2186C>T": 1}}	\N
6513210	6513082	c.85T>C (*9A)/c.2983G>T (*10)	{"DPYD": {"c.85T>C (*9A)": 1, "c.2983G>T (*10)": 1}}	\N
6513211	6513082	c.2983G>T (*10)/c.3061G>C	{"DPYD": {"c.3061G>C": 1, "c.2983G>T (*10)": 1}}	\N
6513212	6513082	c.313G>A/c.2872A>G	{"DPYD": {"c.313G>A": 1, "c.2872A>G": 1}}	\N
6513213	6513082	c.632A>G/c.1905C>G	{"DPYD": {"c.632A>G": 1, "c.1905C>G": 1}}	\N
6513214	6513082	c.1156G>T (*12)/c.2482G>A	{"DPYD": {"c.2482G>A": 1, "c.1156G>T (*12)": 1}}	\N
6513215	6513082	c.451A>G/c.1775G>A	{"DPYD": {"c.451A>G": 1, "c.1775G>A": 1}}	\N
6513216	6513082	c.1905+1G>A (*2A)/c.3061G>C	{"DPYD": {"c.3061G>C": 1, "c.1905+1G>A (*2A)": 1}}	\N
6513217	6513082	c.1349C>T/c.2639G>T	{"DPYD": {"c.1349C>T": 1, "c.2639G>T": 1}}	\N
6513218	6513082	c.62G>A/c.703C>T (*8)	{"DPYD": {"c.62G>A": 1, "c.703C>T (*8)": 1}}	\N
6513219	6513082	c.1057C>T/c.2977C>T	{"DPYD": {"c.1057C>T": 1, "c.2977C>T": 1}}	\N
6513220	6513082	c.632A>G/c.1896T>C	{"DPYD": {"c.632A>G": 1, "c.1896T>C": 1}}	\N
6513221	6513082	c.1156G>T (*12)/c.2582A>G	{"DPYD": {"c.2582A>G": 1, "c.1156G>T (*12)": 1}}	\N
6513222	6513082	c.295_298delTCAT (*7)/c.498G>A	{"DPYD": {"c.498G>A": 1, "c.295_298delTCAT (*7)": 1}}	\N
6513223	6513082	c.62G>A/c.1024G>A	{"DPYD": {"c.62G>A": 1, "c.1024G>A": 1}}	\N
6513224	6513082	c.1403C>A/c.1775G>A	{"DPYD": {"c.1403C>A": 1, "c.1775G>A": 1}}	\N
6513225	6513082	c.1024G>A/c.3061G>C	{"DPYD": {"c.1024G>A": 1, "c.3061G>C": 1}}	\N
6513226	6513082	c.2482G>A/c.2872A>G	{"DPYD": {"c.2482G>A": 1, "c.2872A>G": 1}}	\N
6513227	6513082	c.632A>G/c.934C>T	{"DPYD": {"c.632A>G": 1, "c.934C>T": 1}}	\N
6513228	6513082	c.61C>T/c.2195T>G	{"DPYD": {"c.61C>T": 1, "c.2195T>G": 1}}	\N
6513229	6513082	c.343A>G/c.632A>G	{"DPYD": {"c.343A>G": 1, "c.632A>G": 1}}	\N
6513230	6513082	c.1349C>T/c.2983G>T (*10)	{"DPYD": {"c.1349C>T": 1, "c.2983G>T (*10)": 1}}	\N
6513231	6513082	c.1519G>A/c.1679T>G (*13)	{"DPYD": {"c.1519G>A": 1, "c.1679T>G (*13)": 1}}	\N
6513232	6513082	c.61C>T/c.2657G>A (*9B)	{"DPYD": {"c.61C>T": 1, "c.2657G>A (*9B)": 1}}	\N
6513233	6513082	c.2639G>T/c.2915A>G	{"DPYD": {"c.2639G>T": 1, "c.2915A>G": 1}}	\N
6513234	6513082	c.496A>G/c.1777G>A	{"DPYD": {"c.496A>G": 1, "c.1777G>A": 1}}	\N
6513235	6513082	c.1896T>C/c.2933A>G	{"DPYD": {"c.1896T>C": 1, "c.2933A>G": 1}}	\N
6513236	6513082	c.632A>G/c.929T>C	{"DPYD": {"c.632A>G": 1, "c.929T>C": 1}}	\N
6513237	6513082	c.61C>T/c.1181G>T	{"DPYD": {"c.61C>T": 1, "c.1181G>T": 1}}	\N
6513238	6513082	c.703C>T (*8)/c.2194G>A (*6)	{"DPYD": {"c.703C>T (*8)": 1, "c.2194G>A (*6)": 1}}	\N
6513239	6513082	c.2623A>C/c.2872A>G	{"DPYD": {"c.2623A>C": 1, "c.2872A>G": 1}}	\N
6513240	6513082	c.61C>T/c.1682G>T	{"DPYD": {"c.61C>T": 1, "c.1682G>T": 1}}	\N
6513241	6513082	c.1906A>C/c.2639G>T	{"DPYD": {"c.1906A>C": 1, "c.2639G>T": 1}}	\N
6513242	6513082	c.601A>C/c.775A>G	{"DPYD": {"c.601A>C": 1, "c.775A>G": 1}}	\N
6513243	6513082	c.1108A>G/c.1774C>T	{"DPYD": {"c.1108A>G": 1, "c.1774C>T": 1}}	\N
6513244	6513082	c.1777G>A/c.1796T>C	{"DPYD": {"c.1777G>A": 1, "c.1796T>C": 1}}	\N
6513245	6513082	c.61C>T/c.451A>G	{"DPYD": {"c.61C>T": 1, "c.451A>G": 1}}	\N
6513246	6513082	c.61C>T/c.2623A>C	{"DPYD": {"c.61C>T": 1, "c.2623A>C": 1}}	\N
6513247	6513082	c.1024G>A/c.1601G>A (*4)	{"DPYD": {"c.1024G>A": 1, "c.1601G>A (*4)": 1}}	\N
6513248	6513082	c.934C>T/c.2933A>G	{"DPYD": {"c.934C>T": 1, "c.2933A>G": 1}}	\N
6513249	6513082	c.1024G>A/c.1682G>T	{"DPYD": {"c.1024G>A": 1, "c.1682G>T": 1}}	\N
6513250	6513082	c.1057C>T/c.1906A>C	{"DPYD": {"c.1057C>T": 1, "c.1906A>C": 1}}	\N
6513251	6513082	c.1484A>G/c.2978T>G	{"DPYD": {"c.1484A>G": 1, "c.2978T>G": 1}}	\N
6513252	6513082	c.2872A>G/c.3049G>A	{"DPYD": {"c.2872A>G": 1, "c.3049G>A": 1}}	\N
6513253	6513082	c.85T>C (*9A)/c.1774C>T	{"DPYD": {"c.1774C>T": 1, "c.85T>C (*9A)": 1}}	\N
6513254	6513082	c.1905+1G>A (*2A)/c.2336C>A	{"DPYD": {"c.2336C>A": 1, "c.1905+1G>A (*2A)": 1}}	\N
6513255	6513082	c.62G>A/c.1475C>T	{"DPYD": {"c.62G>A": 1, "c.1475C>T": 1}}	\N
6513256	6513082	c.934C>T/c.2021G>A	{"DPYD": {"c.934C>T": 1, "c.2021G>A": 1}}	\N
6513257	6513082	c.1403C>A/c.1777G>A	{"DPYD": {"c.1403C>A": 1, "c.1777G>A": 1}}	\N
6513258	6513082	c.1156G>T (*12)/c.2195T>G	{"DPYD": {"c.2195T>G": 1, "c.1156G>T (*12)": 1}}	\N
6513259	6513082	c.1260T>A/c.1775G>A	{"DPYD": {"c.1260T>A": 1, "c.1775G>A": 1}}	\N
6513260	6513082	c.1905+1G>A (*2A)/c.2978T>G	{"DPYD": {"c.2978T>G": 1, "c.1905+1G>A (*2A)": 1}}	\N
6513261	6513082	c.451A>G/c.1484A>G	{"DPYD": {"c.451A>G": 1, "c.1484A>G": 1}}	\N
6513262	6513082	c.1156G>T (*12)/c.2657G>A (*9B)	{"DPYD": {"c.1156G>T (*12)": 1, "c.2657G>A (*9B)": 1}}	\N
6513263	6513082	c.62G>A/c.632A>G	{"DPYD": {"c.62G>A": 1, "c.632A>G": 1}}	\N
6513264	6513082	c.1774C>T/c.2186C>T	{"DPYD": {"c.1774C>T": 1, "c.2186C>T": 1}}	\N
6513265	6513082	c.2915A>G/c.2983G>T (*10)	{"DPYD": {"c.2915A>G": 1, "c.2983G>T (*10)": 1}}	\N
6513266	6513082	c.929T>C/c.1777G>A	{"DPYD": {"c.929T>C": 1, "c.1777G>A": 1}}	\N
6513267	6513082	c.525G>A/c.1777G>A	{"DPYD": {"c.525G>A": 1, "c.1777G>A": 1}}	\N
6513268	6513082	c.1679T>G (*13)/c.1796T>C	{"DPYD": {"c.1796T>C": 1, "c.1679T>G (*13)": 1}}	\N
6513269	6513082	c.343A>G/c.1775G>A	{"DPYD": {"c.343A>G": 1, "c.1775G>A": 1}}	\N
6513270	6513082	c.1218G>A/c.1775G>A	{"DPYD": {"c.1218G>A": 1, "c.1775G>A": 1}}	\N
6513271	6513082	c.1796T>C/c.1905+1G>A (*2A)	{"DPYD": {"c.1796T>C": 1, "c.1905+1G>A (*2A)": 1}}	\N
6513272	6513082	c.1774C>T/c.3061G>C	{"DPYD": {"c.1774C>T": 1, "c.3061G>C": 1}}	\N
6513273	6513082	c.1679T>G (*13)/c.2582A>G	{"DPYD": {"c.2582A>G": 1, "c.1679T>G (*13)": 1}}	\N
6513274	6513082	c.703C>T (*8)/c.2186C>T	{"DPYD": {"c.2186C>T": 1, "c.703C>T (*8)": 1}}	\N
6513275	6513082	c.61C>T/c.1905C>G	{"DPYD": {"c.61C>T": 1, "c.1905C>G": 1}}	\N
6513276	6513082	c.46C>G/c.295_298delTCAT (*7)	{"DPYD": {"c.46C>G": 1, "c.295_298delTCAT (*7)": 1}}	\N
6513277	6513082	c.601A>C/c.1218G>A	{"DPYD": {"c.601A>C": 1, "c.1218G>A": 1}}	\N
6513278	6513082	c.1024G>A/c.1627A>G (*5)	{"DPYD": {"c.1024G>A": 1, "c.1627A>G (*5)": 1}}	\N
6513279	6513082	c.1057C>T/c.2194G>A (*6)	{"DPYD": {"c.1057C>T": 1, "c.2194G>A (*6)": 1}}	\N
6513280	6513082	c.1278G>T/c.1679T>G (*13)	{"DPYD": {"c.1278G>T": 1, "c.1679T>G (*13)": 1}}	\N
6513281	6513082	c.2656C>T/c.2872A>G	{"DPYD": {"c.2656C>T": 1, "c.2872A>G": 1}}	\N
6513282	6513082	c.1475C>T/c.2921A>T	{"DPYD": {"c.1475C>T": 1, "c.2921A>T": 1}}	\N
6513283	6513082	c.775A>G/c.2639G>T	{"DPYD": {"c.775A>G": 1, "c.2639G>T": 1}}	\N
6513284	6513082	c.1679T>G (*13)/c.2482G>A	{"DPYD": {"c.2482G>A": 1, "c.1679T>G (*13)": 1}}	\N
6513285	6513082	c.525G>A/c.2933A>G	{"DPYD": {"c.525G>A": 1, "c.2933A>G": 1}}	\N
6513286	6513082	c.1371C>T/c.2639G>T	{"DPYD": {"c.1371C>T": 1, "c.2639G>T": 1}}	\N
6513287	6513082	c.498G>A/c.1777G>A	{"DPYD": {"c.498G>A": 1, "c.1777G>A": 1}}	\N
6513288	6513082	c.1181G>T/c.1484A>G	{"DPYD": {"c.1181G>T": 1, "c.1484A>G": 1}}	\N
6513289	6513082	c.1403C>A/c.2021G>A	{"DPYD": {"c.1403C>A": 1, "c.2021G>A": 1}}	\N
6513290	6513082	c.1349C>T/c.1774C>T	{"DPYD": {"c.1349C>T": 1, "c.1774C>T": 1}}	\N
6513291	6513082	c.1777G>A/c.2656C>T	{"DPYD": {"c.1777G>A": 1, "c.2656C>T": 1}}	\N
6513292	6513082	c.313G>A/c.2639G>T	{"DPYD": {"c.313G>A": 1, "c.2639G>T": 1}}	\N
6513293	6513082	c.1577C>G/c.2639G>T	{"DPYD": {"c.1577C>G": 1, "c.2639G>T": 1}}	\N
6513294	6513082	c.1475C>T/c.3049G>A	{"DPYD": {"c.1475C>T": 1, "c.3049G>A": 1}}	\N
6513295	6513082	c.1898delC (*3)/c.2656C>T	{"DPYD": {"c.2656C>T": 1, "c.1898delC (*3)": 1}}	\N
6513296	6513082	c.61C>T/c.1003G>T (*11)	{"DPYD": {"c.61C>T": 1, "c.1003G>T (*11)": 1}}	\N
6513297	6513082	c.1777G>A/c.2161G>A	{"DPYD": {"c.1777G>A": 1, "c.2161G>A": 1}}	\N
6513298	6513082	c.601A>C/c.2656C>T	{"DPYD": {"c.601A>C": 1, "c.2656C>T": 1}}	\N
6513299	6513082	c.2336C>A/c.2933A>G	{"DPYD": {"c.2336C>A": 1, "c.2933A>G": 1}}	\N
6513300	6513082	c.1615G>A/c.2983G>T (*10)	{"DPYD": {"c.1615G>A": 1, "c.2983G>T (*10)": 1}}	\N
6513301	6513082	c.1898delC (*3)/c.2161G>A	{"DPYD": {"c.2161G>A": 1, "c.1898delC (*3)": 1}}	\N
6513302	6513082	c.967G>A/c.1057C>T	{"DPYD": {"c.967G>A": 1, "c.1057C>T": 1}}	\N
6513303	6513082	c.1156G>T (*12)/c.2336C>A	{"DPYD": {"c.2336C>A": 1, "c.1156G>T (*12)": 1}}	\N
6513304	6513082	c.1601G>A (*4)/c.2872A>G	{"DPYD": {"c.2872A>G": 1, "c.1601G>A (*4)": 1}}	\N
6513305	6513082	c.703C>T (*8)/c.2921A>T	{"DPYD": {"c.2921A>T": 1, "c.703C>T (*8)": 1}}	\N
6513306	6513082	c.1358C>G/c.2933A>G	{"DPYD": {"c.1358C>G": 1, "c.2933A>G": 1}}	\N
6513307	6513082	c.1180C>T/c.2933A>G	{"DPYD": {"c.1180C>T": 1, "c.2933A>G": 1}}	\N
6513308	6513082	c.61C>T/c.525G>A	{"DPYD": {"c.61C>T": 1, "c.525G>A": 1}}	\N
6513309	6513082	c.1774C>T/c.2978T>G	{"DPYD": {"c.1774C>T": 1, "c.2978T>G": 1}}	\N
6513310	6513082	c.451A>G/c.2021G>A	{"DPYD": {"c.451A>G": 1, "c.2021G>A": 1}}	\N
6513311	6513082	c.1108A>G/c.2933A>G	{"DPYD": {"c.1108A>G": 1, "c.2933A>G": 1}}	\N
6513312	6513082	c.2872A>G/c.2921A>T	{"DPYD": {"c.2872A>G": 1, "c.2921A>T": 1}}	\N
6513313	6513082	c.1349C>T/c.1898delC (*3)	{"DPYD": {"c.1349C>T": 1, "c.1898delC (*3)": 1}}	\N
6513314	6513082	c.2186C>T/c.2983G>T (*10)	{"DPYD": {"c.2186C>T": 1, "c.2983G>T (*10)": 1}}	\N
6513315	6513082	c.85T>C (*9A)/c.1898delC (*3)	{"DPYD": {"c.85T>C (*9A)": 1, "c.1898delC (*3)": 1}}	\N
6513316	6513082	c.1024G>A/c.2482G>A	{"DPYD": {"c.1024G>A": 1, "c.2482G>A": 1}}	\N
6513317	6513082	c.1024G>A/c.1543G>A	{"DPYD": {"c.1024G>A": 1, "c.1543G>A": 1}}	\N
6513318	6513082	c.498G>A/c.1024G>A	{"DPYD": {"c.498G>A": 1, "c.1024G>A": 1}}	\N
6513319	6513082	c.295_298delTCAT (*7)/c.3067C>A	{"DPYD": {"c.3067C>A": 1, "c.295_298delTCAT (*7)": 1}}	\N
6513320	6513082	c.2657G>A (*9B)/c.2983G>T (*10)	{"DPYD": {"c.2657G>A (*9B)": 1, "c.2983G>T (*10)": 1}}	\N
6513321	6513082	c.62G>A/c.1679T>G (*13)	{"DPYD": {"c.62G>A": 1, "c.1679T>G (*13)": 1}}	\N
6513322	6513082	c.295_298delTCAT (*7)/c.2303C>A	{"DPYD": {"c.2303C>A": 1, "c.295_298delTCAT (*7)": 1}}	\N
6513323	6513082	c.61C>T/c.1278G>T	{"DPYD": {"c.61C>T": 1, "c.1278G>T": 1}}	\N
6513324	6513082	c.1775G>A/c.2582A>G	{"DPYD": {"c.1775G>A": 1, "c.2582A>G": 1}}	\N
6513325	6513082	c.2872A>G/c.2978T>G	{"DPYD": {"c.2872A>G": 1, "c.2978T>G": 1}}	\N
6513326	6513082	c.1774C>T/c.1896T>C	{"DPYD": {"c.1774C>T": 1, "c.1896T>C": 1}}	\N
6513327	6513082	c.1156G>T (*12)/c.2978T>G	{"DPYD": {"c.2978T>G": 1, "c.1156G>T (*12)": 1}}	\N
6513328	6513082	c.1679T>G (*13)/c.1682G>T	{"DPYD": {"c.1682G>T": 1, "c.1679T>G (*13)": 1}}	\N
6513329	6513082	c.295_298delTCAT (*7)/c.1906A>C	{"DPYD": {"c.1906A>C": 1, "c.295_298delTCAT (*7)": 1}}	\N
6513330	6513082	c.295_298delTCAT (*7)/c.2657G>A (*9B)	{"DPYD": {"c.2657G>A (*9B)": 1, "c.295_298delTCAT (*7)": 1}}	\N
6513331	6513082	c.295_298delTCAT (*7)/c.496A>G	{"DPYD": {"c.496A>G": 1, "c.295_298delTCAT (*7)": 1}}	\N
6513332	6513082	c.1519G>A/c.1898delC (*3)	{"DPYD": {"c.1519G>A": 1, "c.1898delC (*3)": 1}}	\N
6513333	6513082	c.2195T>G/c.2983G>T (*10)	{"DPYD": {"c.2195T>G": 1, "c.2983G>T (*10)": 1}}	\N
6513334	6513082	c.295_298delTCAT (*7)/c.2195T>G	{"DPYD": {"c.2195T>G": 1, "c.295_298delTCAT (*7)": 1}}	\N
6513335	6513082	c.703C>T (*8)/c.1294G>A	{"DPYD": {"c.1294G>A": 1, "c.703C>T (*8)": 1}}	\N
6513336	6513082	c.1024G>A/c.1796T>C	{"DPYD": {"c.1024G>A": 1, "c.1796T>C": 1}}	\N
6513337	6513082	c.1024G>A/c.1108A>G	{"DPYD": {"c.1024G>A": 1, "c.1108A>G": 1}}	\N
6513338	6513082	c.1484A>G/c.2186C>T	{"DPYD": {"c.1484A>G": 1, "c.2186C>T": 1}}	\N
6513339	6513082	c.1024G>A/Reference	{"DPYD": {"Reference": 1, "c.1024G>A": 1}}	\N
6513340	6513082	c.1024G>A/c.1260T>A	{"DPYD": {"c.1024G>A": 1, "c.1260T>A": 1}}	\N
6513341	6513082	c.1294G>A/c.2933A>G	{"DPYD": {"c.1294G>A": 1, "c.2933A>G": 1}}	\N
6513342	6513082	c.632A>G/c.1278G>T	{"DPYD": {"c.632A>G": 1, "c.1278G>T": 1}}	\N
6513343	6513082	c.1156G>T (*12)/c.1896T>C	{"DPYD": {"c.1896T>C": 1, "c.1156G>T (*12)": 1}}	\N
6513344	6513082	c.1905C>G/c.2021G>A	{"DPYD": {"c.1905C>G": 1, "c.2021G>A": 1}}	\N
6513345	6513082	c.2021G>A/c.2657G>A (*9B)	{"DPYD": {"c.2021G>A": 1, "c.2657G>A (*9B)": 1}}	\N
6513346	6513082	c.295_298delTCAT (*7)/c.1990G>T	{"DPYD": {"c.1990G>T": 1, "c.295_298delTCAT (*7)": 1}}	\N
6513347	6513082	c.1358C>G/c.1905+1G>A (*2A)	{"DPYD": {"c.1358C>G": 1, "c.1905+1G>A (*2A)": 1}}	\N
6513348	6513082	c.2021G>A/c.2195T>G	{"DPYD": {"c.2021G>A": 1, "c.2195T>G": 1}}	\N
6513349	6513082	c.46C>G/c.1484A>G	{"DPYD": {"c.46C>G": 1, "c.1484A>G": 1}}	\N
6513350	6513082	c.2582A>G/c.2983G>T (*10)	{"DPYD": {"c.2582A>G": 1, "c.2983G>T (*10)": 1}}	\N
6513351	6513082	c.1003G>T (*11)/c.2933A>G	{"DPYD": {"c.2933A>G": 1, "c.1003G>T (*11)": 1}}	\N
6513352	6513082	c.1475C>T/c.1519G>A	{"DPYD": {"c.1475C>T": 1, "c.1519G>A": 1}}	\N
6513353	6513082	c.1484A>G/c.3049G>A	{"DPYD": {"c.1484A>G": 1, "c.3049G>A": 1}}	\N
6513354	6513082	c.1679T>G (*13)/c.2656C>T	{"DPYD": {"c.2656C>T": 1, "c.1679T>G (*13)": 1}}	\N
6513355	6513082	c.61C>T/c.967G>A	{"DPYD": {"c.61C>T": 1, "c.967G>A": 1}}	\N
6513356	6513082	c.295_298delTCAT (*7)/c.2194G>A (*6)	{"DPYD": {"c.2194G>A (*6)": 1, "c.295_298delTCAT (*7)": 1}}	\N
6513357	6513082	c.1475C>T/c.2582A>G	{"DPYD": {"c.1475C>T": 1, "c.2582A>G": 1}}	\N
6513358	6513082	c.1905+1G>A (*2A)/c.2195T>G	{"DPYD": {"c.2195T>G": 1, "c.1905+1G>A (*2A)": 1}}	\N
6513359	6513082	c.2021G>A/c.2336C>A	{"DPYD": {"c.2021G>A": 1, "c.2336C>A": 1}}	\N
6513360	6513082	c.1775G>A/Reference	{"DPYD": {"Reference": 1, "c.1775G>A": 1}}	\N
6513361	6513082	c.46C>G/c.1024G>A	{"DPYD": {"c.46C>G": 1, "c.1024G>A": 1}}	\N
6513362	6513082	c.632A>G/c.1003G>T (*11)	{"DPYD": {"c.632A>G": 1, "c.1003G>T (*11)": 1}}	\N
6513363	6513082	c.703C>T (*8)/c.2978T>G	{"DPYD": {"c.2978T>G": 1, "c.703C>T (*8)": 1}}	\N
6513364	6513082	c.1905+1G>A (*2A)/c.2657G>A (*9B)	{"DPYD": {"c.2657G>A (*9B)": 1, "c.1905+1G>A (*2A)": 1}}	\N
6513365	6513082	c.46C>G/c.703C>T (*8)	{"DPYD": {"c.46C>G": 1, "c.703C>T (*8)": 1}}	\N
6513366	6513082	c.525G>A/c.1775G>A	{"DPYD": {"c.525G>A": 1, "c.1775G>A": 1}}	\N
6513367	6513082	c.632A>G/c.1358C>G	{"DPYD": {"c.632A>G": 1, "c.1358C>G": 1}}	\N
6513368	6513082	c.967G>A/c.1905+1G>A (*2A)	{"DPYD": {"c.967G>A": 1, "c.1905+1G>A (*2A)": 1}}	\N
6513369	6513082	c.2582A>G/c.2639G>T	{"DPYD": {"c.2582A>G": 1, "c.2639G>T": 1}}	\N
6513370	6513082	c.703C>T (*8)/c.3049G>A	{"DPYD": {"c.3049G>A": 1, "c.703C>T (*8)": 1}}	\N
6513371	6513082	c.929T>C/c.1775G>A	{"DPYD": {"c.929T>C": 1, "c.1775G>A": 1}}	\N
6513372	6513082	c.1484A>G/Reference	{"DPYD": {"Reference": 1, "c.1484A>G": 1}}	\N
6513373	6513082	c.85T>C (*9A)/c.2872A>G	{"DPYD": {"c.2872A>G": 1, "c.85T>C (*9A)": 1}}	\N
6513374	6513082	c.1180C>T/c.2872A>G	{"DPYD": {"c.1180C>T": 1, "c.2872A>G": 1}}	\N
6513375	6513082	c.1181G>T/c.1774C>T	{"DPYD": {"c.1181G>T": 1, "c.1774C>T": 1}}	\N
6513376	6513082	c.934C>T/c.1156G>T (*12)	{"DPYD": {"c.934C>T": 1, "c.1156G>T (*12)": 1}}	\N
6513377	6513082	c.1156G>T (*12)/c.2186C>T	{"DPYD": {"c.2186C>T": 1, "c.1156G>T (*12)": 1}}	\N
6513378	6513082	c.61C>T/c.2656C>T	{"DPYD": {"c.61C>T": 1, "c.2656C>T": 1}}	\N
6513379	6513082	c.703C>T (*8)/c.3067C>A	{"DPYD": {"c.3067C>A": 1, "c.703C>T (*8)": 1}}	\N
6513380	6513082	c.2303C>A/c.2933A>G	{"DPYD": {"c.2303C>A": 1, "c.2933A>G": 1}}	\N
6513381	6513082	c.1774C>T/c.2657G>A (*9B)	{"DPYD": {"c.1774C>T": 1, "c.2657G>A (*9B)": 1}}	\N
6513382	6513082	c.2978T>G/c.2983G>T (*10)	{"DPYD": {"c.2978T>G": 1, "c.2983G>T (*10)": 1}}	\N
6513383	6513082	c.1774C>T/c.2195T>G	{"DPYD": {"c.1774C>T": 1, "c.2195T>G": 1}}	\N
6513384	6513082	c.2639G>T/c.2921A>T	{"DPYD": {"c.2639G>T": 1, "c.2921A>T": 1}}	\N
6513385	6513082	c.1057C>T/c.1181G>T	{"DPYD": {"c.1057C>T": 1, "c.1181G>T": 1}}	\N
6513386	6513082	c.1484A>G/c.2921A>T	{"DPYD": {"c.1484A>G": 1, "c.2921A>T": 1}}	\N
6513387	6513082	c.929T>C/c.2872A>G	{"DPYD": {"c.929T>C": 1, "c.2872A>G": 1}}	\N
6513388	6513082	c.703C>T (*8)/c.1278G>T	{"DPYD": {"c.1278G>T": 1, "c.703C>T (*8)": 1}}	\N
6513389	6513082	c.295_298delTCAT (*7)/c.775A>G	{"DPYD": {"c.775A>G": 1, "c.295_298delTCAT (*7)": 1}}	\N
6513390	6513082	c.1898delC (*3)/c.3049G>A	{"DPYD": {"c.3049G>A": 1, "c.1898delC (*3)": 1}}	\N
6513391	6513082	c.1484A>G/c.2623A>C	{"DPYD": {"c.1484A>G": 1, "c.2623A>C": 1}}	\N
6513392	6513082	c.2021G>A/c.2977C>T	{"DPYD": {"c.2021G>A": 1, "c.2977C>T": 1}}	\N
6513393	6513082	c.775A>G/c.1679T>G (*13)	{"DPYD": {"c.775A>G": 1, "c.1679T>G (*13)": 1}}	\N
6513394	6513082	c.1906A>C/c.2983G>T (*10)	{"DPYD": {"c.1906A>C": 1, "c.2983G>T (*10)": 1}}	\N
6513395	6513082	c.601A>C/c.2915A>G	{"DPYD": {"c.601A>C": 1, "c.2915A>G": 1}}	\N
6513396	6513082	c.1358C>G/c.1679T>G (*13)	{"DPYD": {"c.1358C>G": 1, "c.1679T>G (*13)": 1}}	\N
6513397	6513082	c.1679T>G (*13)/c.2623A>C	{"DPYD": {"c.2623A>C": 1, "c.1679T>G (*13)": 1}}	\N
6513398	6513082	c.1057C>T/c.1615G>A	{"DPYD": {"c.1057C>T": 1, "c.1615G>A": 1}}	\N
6513399	6513082	c.934C>T/c.1775G>A	{"DPYD": {"c.934C>T": 1, "c.1775G>A": 1}}	\N
6513400	6513082	c.2021G>A/c.2186C>T	{"DPYD": {"c.2021G>A": 1, "c.2186C>T": 1}}	\N
6513401	6513082	c.46C>G/c.2983G>T (*10)	{"DPYD": {"c.46C>G": 1, "c.2983G>T (*10)": 1}}	\N
6513402	6513082	c.1003G>T (*11)/c.2639G>T	{"DPYD": {"c.2639G>T": 1, "c.1003G>T (*11)": 1}}	\N
6513403	6513082	c.498G>A/c.2872A>G	{"DPYD": {"c.498G>A": 1, "c.2872A>G": 1}}	\N
6513404	6513082	c.295_298delTCAT (*7)/c.1294G>A	{"DPYD": {"c.1294G>A": 1, "c.295_298delTCAT (*7)": 1}}	\N
6513405	6513082	c.1627A>G (*5)/c.1775G>A	{"DPYD": {"c.1775G>A": 1, "c.1627A>G (*5)": 1}}	\N
6513406	6513082	c.703C>T (*8)/c.2303C>A	{"DPYD": {"c.2303C>A": 1, "c.703C>T (*8)": 1}}	\N
6513407	6513082	c.934C>T/c.1475C>T	{"DPYD": {"c.934C>T": 1, "c.1475C>T": 1}}	\N
6513408	6513082	c.775A>G/c.1475C>T	{"DPYD": {"c.775A>G": 1, "c.1475C>T": 1}}	\N
6513409	6513082	c.295_298delTCAT (*7)/c.2161G>A	{"DPYD": {"c.2161G>A": 1, "c.295_298delTCAT (*7)": 1}}	\N
6513410	6513082	c.295_298delTCAT (*7)/c.1371C>T	{"DPYD": {"c.1371C>T": 1, "c.295_298delTCAT (*7)": 1}}	\N
6513411	6513082	c.2482G>A/c.2639G>T	{"DPYD": {"c.2482G>A": 1, "c.2639G>T": 1}}	\N
6513412	6513082	c.295_298delTCAT (*7)/c.2582A>G	{"DPYD": {"c.2582A>G": 1, "c.295_298delTCAT (*7)": 1}}	\N
6513413	6513082	c.313G>A/c.1156G>T (*12)	{"DPYD": {"c.313G>A": 1, "c.1156G>T (*12)": 1}}	\N
6513414	6513082	c.62G>A/c.1898delC (*3)	{"DPYD": {"c.62G>A": 1, "c.1898delC (*3)": 1}}	\N
6513415	6513082	c.632A>G/c.1796T>C	{"DPYD": {"c.632A>G": 1, "c.1796T>C": 1}}	\N
6513416	6513082	c.1577C>G/c.2983G>T (*10)	{"DPYD": {"c.1577C>G": 1, "c.2983G>T (*10)": 1}}	\N
6513417	6513082	c.2977C>T/c.2983G>T (*10)	{"DPYD": {"c.2977C>T": 1, "c.2983G>T (*10)": 1}}	\N
6513418	6513082	c.525G>A/c.1024G>A	{"DPYD": {"c.525G>A": 1, "c.1024G>A": 1}}	\N
6513419	6513082	c.967G>A/c.1024G>A	{"DPYD": {"c.967G>A": 1, "c.1024G>A": 1}}	\N
6513420	6513082	c.1484A>G/c.1519G>A	{"DPYD": {"c.1484A>G": 1, "c.1519G>A": 1}}	\N
6513421	6513082	c.1774C>T/c.2915A>G	{"DPYD": {"c.1774C>T": 1, "c.2915A>G": 1}}	\N
6513422	6513082	c.61C>T/c.498G>A	{"DPYD": {"c.61C>T": 1, "c.498G>A": 1}}	\N
6513423	6513082	c.1057C>T/c.2915A>G	{"DPYD": {"c.1057C>T": 1, "c.2915A>G": 1}}	\N
6513424	6513082	c.1024G>A/c.2582A>G	{"DPYD": {"c.1024G>A": 1, "c.2582A>G": 1}}	\N
6513425	6513082	c.61C>T/c.2978T>G	{"DPYD": {"c.61C>T": 1, "c.2978T>G": 1}}	\N
6513426	6513082	c.46C>G/c.1475C>T	{"DPYD": {"c.46C>G": 1, "c.1475C>T": 1}}	\N
6513427	6513082	c.1475C>T/c.2194G>A (*6)	{"DPYD": {"c.1475C>T": 1, "c.2194G>A (*6)": 1}}	\N
6513428	6513082	c.1777G>A/c.2303C>A	{"DPYD": {"c.1777G>A": 1, "c.2303C>A": 1}}	\N
6513429	6513082	c.1358C>G/c.2021G>A	{"DPYD": {"c.1358C>G": 1, "c.2021G>A": 1}}	\N
6513430	6513082	c.451A>G/c.2933A>G	{"DPYD": {"c.451A>G": 1, "c.2933A>G": 1}}	\N
6513431	6513082	c.929T>C/c.1024G>A	{"DPYD": {"c.929T>C": 1, "c.1024G>A": 1}}	\N
6513432	6513082	c.632A>G/c.2195T>G	{"DPYD": {"c.632A>G": 1, "c.2195T>G": 1}}	\N
6513433	6513082	c.343A>G/c.1777G>A	{"DPYD": {"c.343A>G": 1, "c.1777G>A": 1}}	\N
6513434	6513082	c.632A>G/c.2657G>A (*9B)	{"DPYD": {"c.632A>G": 1, "c.2657G>A (*9B)": 1}}	\N
6513435	6513082	c.295_298delTCAT (*7)/c.1615G>A	{"DPYD": {"c.1615G>A": 1, "c.295_298delTCAT (*7)": 1}}	\N
6513436	6513082	c.601A>C/c.2657G>A (*9B)	{"DPYD": {"c.601A>C": 1, "c.2657G>A (*9B)": 1}}	\N
6513437	6513082	c.1627A>G (*5)/c.1777G>A	{"DPYD": {"c.1777G>A": 1, "c.1627A>G (*5)": 1}}	\N
6513438	6513082	c.601A>C/c.2195T>G	{"DPYD": {"c.601A>C": 1, "c.2195T>G": 1}}	\N
6513439	6513082	c.632A>G/c.1577C>G	{"DPYD": {"c.632A>G": 1, "c.1577C>G": 1}}	\N
6513440	6513082	c.2639G>T/c.3061G>C	{"DPYD": {"c.2639G>T": 1, "c.3061G>C": 1}}	\N
6513441	6513082	c.703C>T (*8)/c.1519G>A	{"DPYD": {"c.1519G>A": 1, "c.703C>T (*8)": 1}}	\N
6513442	6513082	c.1024G>A/c.1294G>A	{"DPYD": {"c.1024G>A": 1, "c.1294G>A": 1}}	\N
6513443	6513082	c.343A>G/c.703C>T (*8)	{"DPYD": {"c.343A>G": 1, "c.703C>T (*8)": 1}}	\N
6513444	6513082	c.1024G>A/c.1577C>G	{"DPYD": {"c.1024G>A": 1, "c.1577C>G": 1}}	\N
6513445	6513082	c.1371C>T/c.1905+1G>A (*2A)	{"DPYD": {"c.1371C>T": 1, "c.1905+1G>A (*2A)": 1}}	\N
6513446	6513082	c.2161G>A/c.2983G>T (*10)	{"DPYD": {"c.2161G>A": 1, "c.2983G>T (*10)": 1}}	\N
6513447	6513082	c.1057C>T/c.1627A>G (*5)	{"DPYD": {"c.1057C>T": 1, "c.1627A>G (*5)": 1}}	\N
6513448	6513082	c.1484A>G/c.1601G>A (*4)	{"DPYD": {"c.1484A>G": 1, "c.1601G>A (*4)": 1}}	\N
6513449	6513082	c.2623A>C/c.2639G>T	{"DPYD": {"c.2623A>C": 1, "c.2639G>T": 1}}	\N
6513450	6513082	c.1278G>T/c.1777G>A	{"DPYD": {"c.1278G>T": 1, "c.1777G>A": 1}}	\N
6513451	6513082	c.1294G>A/c.1898delC (*3)	{"DPYD": {"c.1294G>A": 1, "c.1898delC (*3)": 1}}	\N
6513452	6513082	c.313G>A/c.1905+1G>A (*2A)	{"DPYD": {"c.313G>A": 1, "c.1905+1G>A (*2A)": 1}}	\N
6513453	6513082	c.775A>G/c.1774C>T	{"DPYD": {"c.775A>G": 1, "c.1774C>T": 1}}	\N
6513454	6513082	c.1003G>T (*11)/c.1679T>G (*13)	{"DPYD": {"c.1003G>T (*11)": 1, "c.1679T>G (*13)": 1}}	\N
6513455	6513082	c.1679T>G (*13)/c.3049G>A	{"DPYD": {"c.3049G>A": 1, "c.1679T>G (*13)": 1}}	\N
6513456	6513082	c.1057C>T/c.1371C>T	{"DPYD": {"c.1057C>T": 1, "c.1371C>T": 1}}	\N
6513457	6513082	c.1024G>A/c.1180C>T	{"DPYD": {"c.1024G>A": 1, "c.1180C>T": 1}}	\N
6513458	6513082	c.1543G>A/c.2872A>G	{"DPYD": {"c.1543G>A": 1, "c.2872A>G": 1}}	\N
6513459	6513082	c.1679T>G (*13)/c.1905C>G	{"DPYD": {"c.1905C>G": 1, "c.1679T>G (*13)": 1}}	\N
6513460	6513082	c.1898delC (*3)/c.2194G>A (*6)	{"DPYD": {"c.2194G>A (*6)": 1, "c.1898delC (*3)": 1}}	\N
6513461	6513082	c.1475C>T/c.2195T>G	{"DPYD": {"c.1475C>T": 1, "c.2195T>G": 1}}	\N
6513462	6513082	c.1484A>G/c.2303C>A	{"DPYD": {"c.1484A>G": 1, "c.2303C>A": 1}}	\N
6513463	6513082	c.62G>A/c.1484A>G	{"DPYD": {"c.62G>A": 1, "c.1484A>G": 1}}	\N
6513464	6513082	c.1777G>A/c.2194G>A (*6)	{"DPYD": {"c.1777G>A": 1, "c.2194G>A (*6)": 1}}	\N
6513465	6513082	c.1475C>T/c.2657G>A (*9B)	{"DPYD": {"c.1475C>T": 1, "c.2657G>A (*9B)": 1}}	\N
6513466	6513082	c.1484A>G/c.1682G>T	{"DPYD": {"c.1484A>G": 1, "c.1682G>T": 1}}	\N
6513467	6513082	c.1484A>G/c.3067C>A	{"DPYD": {"c.1484A>G": 1, "c.3067C>A": 1}}	\N
6513468	6513082	c.1475C>T/c.1682G>T	{"DPYD": {"c.1475C>T": 1, "c.1682G>T": 1}}	\N
6513469	6513082	c.1774C>T/c.2582A>G	{"DPYD": {"c.1774C>T": 1, "c.2582A>G": 1}}	\N
6513470	6513082	c.1601G>A (*4)/c.2933A>G	{"DPYD": {"c.2933A>G": 1, "c.1601G>A (*4)": 1}}	\N
6513471	6513082	c.1475C>T/c.1601G>A (*4)	{"DPYD": {"c.1475C>T": 1, "c.1601G>A (*4)": 1}}	\N
6513472	6513082	c.1601G>A (*4)/c.2639G>T	{"DPYD": {"c.2639G>T": 1, "c.1601G>A (*4)": 1}}	\N
6513473	6513082	c.1484A>G/c.2194G>A (*6)	{"DPYD": {"c.1484A>G": 1, "c.2194G>A (*6)": 1}}	\N
6513474	6513082	c.934C>T/c.1679T>G (*13)	{"DPYD": {"c.934C>T": 1, "c.1679T>G (*13)": 1}}	\N
6513475	6513082	c.46C>G/c.1679T>G (*13)	{"DPYD": {"c.46C>G": 1, "c.1679T>G (*13)": 1}}	\N
6513476	6513082	c.1003G>T (*11)/c.2021G>A	{"DPYD": {"c.2021G>A": 1, "c.1003G>T (*11)": 1}}	\N
6513477	6513082	c.1990G>T/c.2933A>G	{"DPYD": {"c.1990G>T": 1, "c.2933A>G": 1}}	\N
6513478	6513082	c.1543G>A/c.2933A>G	{"DPYD": {"c.1543G>A": 1, "c.2933A>G": 1}}	\N
6513479	6513082	c.295_298delTCAT (*7)/c.2915A>G	{"DPYD": {"c.2915A>G": 1, "c.295_298delTCAT (*7)": 1}}	\N
6513480	6513082	c.1679T>G (*13)/c.2161G>A	{"DPYD": {"c.2161G>A": 1, "c.1679T>G (*13)": 1}}	\N
6513481	6513082	c.2161G>A/c.2933A>G	{"DPYD": {"c.2161G>A": 1, "c.2933A>G": 1}}	\N
6513482	6513082	c.1181G>T/c.2983G>T (*10)	{"DPYD": {"c.1181G>T": 1, "c.2983G>T (*10)": 1}}	\N
6513483	6513082	c.2921A>T/c.2983G>T (*10)	{"DPYD": {"c.2921A>T": 1, "c.2983G>T (*10)": 1}}	\N
6513484	6513082	c.1796T>C/c.2983G>T (*10)	{"DPYD": {"c.1796T>C": 1, "c.2983G>T (*10)": 1}}	\N
6513485	6513082	c.295_298delTCAT (*7)/c.3061G>C	{"DPYD": {"c.3061G>C": 1, "c.295_298delTCAT (*7)": 1}}	\N
6513486	6513082	c.1577C>G/c.1679T>G (*13)	{"DPYD": {"c.1577C>G": 1, "c.1679T>G (*13)": 1}}	\N
6513487	6513082	c.1990G>T/c.2639G>T	{"DPYD": {"c.1990G>T": 1, "c.2639G>T": 1}}	\N
6513488	6513082	c.632A>G/c.1180C>T	{"DPYD": {"c.632A>G": 1, "c.1180C>T": 1}}	\N
6513489	6513082	c.929T>C/c.1905+1G>A (*2A)	{"DPYD": {"c.929T>C": 1, "c.1905+1G>A (*2A)": 1}}	\N
6513490	6513082	c.2021G>A/c.2915A>G	{"DPYD": {"c.2021G>A": 1, "c.2915A>G": 1}}	\N
6513491	6513082	c.525G>A/c.1905+1G>A (*2A)	{"DPYD": {"c.525G>A": 1, "c.1905+1G>A (*2A)": 1}}	\N
6513492	6513082	c.1156G>T (*12)/c.1278G>T	{"DPYD": {"c.1278G>T": 1, "c.1156G>T (*12)": 1}}	\N
6513493	6513082	c.1775G>A/c.2978T>G	{"DPYD": {"c.1775G>A": 1, "c.2978T>G": 1}}	\N
6513494	6513082	c.496A>G/c.2872A>G	{"DPYD": {"c.496A>G": 1, "c.2872A>G": 1}}	\N
6513495	6513082	c.1260T>A/c.1777G>A	{"DPYD": {"c.1260T>A": 1, "c.1777G>A": 1}}	\N
6513496	6513082	c.632A>G/c.1349C>T	{"DPYD": {"c.632A>G": 1, "c.1349C>T": 1}}	\N
6513497	6513082	c.1358C>G/c.1775G>A	{"DPYD": {"c.1358C>G": 1, "c.1775G>A": 1}}	\N
6513498	6513082	c.313G>A/c.1777G>A	{"DPYD": {"c.313G>A": 1, "c.1777G>A": 1}}	\N
6513499	6513082	c.703C>T (*8)/Reference	{"DPYD": {"Reference": 1, "c.703C>T (*8)": 1}}	\N
6513500	6513082	c.525G>A/c.2872A>G	{"DPYD": {"c.525G>A": 1, "c.2872A>G": 1}}	\N
6513501	6513082	c.2194G>A (*6)/c.2639G>T	{"DPYD": {"c.2639G>T": 1, "c.2194G>A (*6)": 1}}	\N
6513502	6513082	c.61C>T/c.1218G>A	{"DPYD": {"c.61C>T": 1, "c.1218G>A": 1}}	\N
6513503	6513082	c.1475C>T/c.1615G>A	{"DPYD": {"c.1475C>T": 1, "c.1615G>A": 1}}	\N
6513504	6513082	c.601A>C/c.1108A>G	{"DPYD": {"c.601A>C": 1, "c.1108A>G": 1}}	\N
6513505	6513082	c.1615G>A/c.2872A>G	{"DPYD": {"c.1615G>A": 1, "c.2872A>G": 1}}	\N
6513506	6513082	c.1775G>A/c.2623A>C	{"DPYD": {"c.1775G>A": 1, "c.2623A>C": 1}}	\N
6513507	6513082	c.1218G>A/c.1777G>A	{"DPYD": {"c.1218G>A": 1, "c.1777G>A": 1}}	\N
6513508	6513082	c.46C>G/c.1774C>T	{"DPYD": {"c.46C>G": 1, "c.1774C>T": 1}}	\N
6513509	6513082	c.1775G>A/c.1905C>G	{"DPYD": {"c.1775G>A": 1, "c.1905C>G": 1}}	\N
6513510	6513082	c.1615G>A/c.1905+1G>A (*2A)	{"DPYD": {"c.1615G>A": 1, "c.1905+1G>A (*2A)": 1}}	\N
6513511	6513082	c.61C>T/c.2303C>A	{"DPYD": {"c.61C>T": 1, "c.2303C>A": 1}}	\N
6513512	6513082	c.1371C>T/c.1777G>A	{"DPYD": {"c.1371C>T": 1, "c.1777G>A": 1}}	\N
6513513	6513082	c.1777G>A/c.2482G>A	{"DPYD": {"c.1777G>A": 1, "c.2482G>A": 1}}	\N
6513514	6513082	c.1358C>G/c.1475C>T	{"DPYD": {"c.1358C>G": 1, "c.1475C>T": 1}}	\N
6513515	6513082	c.1543G>A/c.2639G>T	{"DPYD": {"c.1543G>A": 1, "c.2639G>T": 1}}	\N
6513516	6513082	c.61C>T/c.3067C>A	{"DPYD": {"c.61C>T": 1, "c.3067C>A": 1}}	\N
6513517	6513082	c.85T>C (*9A)/c.1024G>A	{"DPYD": {"c.1024G>A": 1, "c.85T>C (*9A)": 1}}	\N
6513518	6513082	c.1627A>G (*5)/c.2021G>A	{"DPYD": {"c.2021G>A": 1, "c.1627A>G (*5)": 1}}	\N
6513519	6513082	c.1898delC (*3)/c.2482G>A	{"DPYD": {"c.2482G>A": 1, "c.1898delC (*3)": 1}}	\N
6513520	6513082	c.934C>T/c.1777G>A	{"DPYD": {"c.934C>T": 1, "c.1777G>A": 1}}	\N
6513521	6513082	c.1577C>G/c.1774C>T	{"DPYD": {"c.1577C>G": 1, "c.1774C>T": 1}}	\N
6513522	6513082	c.61C>T/c.1108A>G	{"DPYD": {"c.61C>T": 1, "c.1108A>G": 1}}	\N
6513523	6513082	c.1777G>A/c.2978T>G	{"DPYD": {"c.1777G>A": 1, "c.2978T>G": 1}}	\N
6513524	6513082	c.1775G>A/c.2915A>G	{"DPYD": {"c.1775G>A": 1, "c.2915A>G": 1}}	\N
6513525	6513082	c.703C>T (*8)/c.1682G>T	{"DPYD": {"c.1682G>T": 1, "c.703C>T (*8)": 1}}	\N
6513526	6513082	c.1679T>G (*13)/c.2978T>G	{"DPYD": {"c.2978T>G": 1, "c.1679T>G (*13)": 1}}	\N
6513527	6513082	c.46C>G/c.61C>T	{"DPYD": {"c.46C>G": 1, "c.61C>T": 1}}	\N
6513528	6513082	c.632A>G/c.1403C>A	{"DPYD": {"c.632A>G": 1, "c.1403C>A": 1}}	\N
6513529	6513082	c.1024G>A/c.1358C>G	{"DPYD": {"c.1024G>A": 1, "c.1358C>G": 1}}	\N
6513530	6513082	c.1294G>A/c.2983G>T (*10)	{"DPYD": {"c.1294G>A": 1, "c.2983G>T (*10)": 1}}	\N
6513531	6513082	c.601A>C/c.2978T>G	{"DPYD": {"c.601A>C": 1, "c.2978T>G": 1}}	\N
6513532	6513082	c.632A>G/c.3049G>A	{"DPYD": {"c.632A>G": 1, "c.3049G>A": 1}}	\N
6513533	6513082	c.343A>G/c.1156G>T (*12)	{"DPYD": {"c.343A>G": 1, "c.1156G>T (*12)": 1}}	\N
6513534	6513082	c.2021G>A/c.2623A>C	{"DPYD": {"c.2021G>A": 1, "c.2623A>C": 1}}	\N
6513535	6513082	c.775A>G/c.1898delC (*3)	{"DPYD": {"c.775A>G": 1, "c.1898delC (*3)": 1}}	\N
6513536	6513082	c.1358C>G/c.1777G>A	{"DPYD": {"c.1358C>G": 1, "c.1777G>A": 1}}	\N
6513537	6513082	c.1057C>T/c.1682G>T	{"DPYD": {"c.1057C>T": 1, "c.1682G>T": 1}}	\N
6513538	6513082	c.1024G>A/c.1906A>C	{"DPYD": {"c.1024G>A": 1, "c.1906A>C": 1}}	\N
6513539	6513082	c.62G>A/c.2983G>T (*10)	{"DPYD": {"c.62G>A": 1, "c.2983G>T (*10)": 1}}	\N
6513540	6513082	c.934C>T/c.2639G>T	{"DPYD": {"c.934C>T": 1, "c.2639G>T": 1}}	\N
6513541	6513082	c.2933A>G/c.3061G>C	{"DPYD": {"c.2933A>G": 1, "c.3061G>C": 1}}	\N
6513542	6513082	c.1003G>T (*11)/c.1057C>T	{"DPYD": {"c.1057C>T": 1, "c.1003G>T (*11)": 1}}	\N
6513543	6513082	c.313G>A/c.2021G>A	{"DPYD": {"c.313G>A": 1, "c.2021G>A": 1}}	\N
6513544	6513082	c.1180C>T/c.1774C>T	{"DPYD": {"c.1180C>T": 1, "c.1774C>T": 1}}	\N
6513545	6513082	c.1057C>T/c.1601G>A (*4)	{"DPYD": {"c.1057C>T": 1, "c.1601G>A (*4)": 1}}	\N
6513546	6513082	c.496A>G/c.1905+1G>A (*2A)	{"DPYD": {"c.496A>G": 1, "c.1905+1G>A (*2A)": 1}}	\N
6513547	6513082	c.61C>T/c.1543G>A	{"DPYD": {"c.61C>T": 1, "c.1543G>A": 1}}	\N
6513548	6513082	c.2194G>A (*6)/c.2933A>G	{"DPYD": {"c.2933A>G": 1, "c.2194G>A (*6)": 1}}	\N
6513549	6513082	c.967G>A/c.1774C>T	{"DPYD": {"c.967G>A": 1, "c.1774C>T": 1}}	\N
6513550	6513082	c.1371C>T/c.2021G>A	{"DPYD": {"c.1371C>T": 1, "c.2021G>A": 1}}	\N
6513551	6513082	c.1484A>G/c.2161G>A	{"DPYD": {"c.1484A>G": 1, "c.2161G>A": 1}}	\N
6513552	6513082	c.1156G>T (*12)/c.1181G>T	{"DPYD": {"c.1181G>T": 1, "c.1156G>T (*12)": 1}}	\N
6513553	6513082	c.2336C>A/c.2639G>T	{"DPYD": {"c.2336C>A": 1, "c.2639G>T": 1}}	\N
6513554	6513082	c.703C>T (*8)/c.929T>C	{"DPYD": {"c.929T>C": 1, "c.703C>T (*8)": 1}}	\N
6513555	6513082	c.1990G>T/c.2021G>A	{"DPYD": {"c.1990G>T": 1, "c.2021G>A": 1}}	\N
6513556	6513082	c.1627A>G (*5)/c.2933A>G	{"DPYD": {"c.2933A>G": 1, "c.1627A>G (*5)": 1}}	\N
6513557	6513082	c.1260T>A/c.1475C>T	{"DPYD": {"c.1260T>A": 1, "c.1475C>T": 1}}	\N
6513558	6513082	c.2639G>T/c.2977C>T	{"DPYD": {"c.2639G>T": 1, "c.2977C>T": 1}}	\N
6513559	6513082	c.1601G>A (*4)/c.2021G>A	{"DPYD": {"c.2021G>A": 1, "c.1601G>A (*4)": 1}}	\N
6513560	6513082	c.1156G>T (*12)/c.1905C>G	{"DPYD": {"c.1905C>G": 1, "c.1156G>T (*12)": 1}}	\N
6513561	6513082	c.1156G>T (*12)/c.1260T>A	{"DPYD": {"c.1260T>A": 1, "c.1156G>T (*12)": 1}}	\N
6513562	6513082	c.295_298delTCAT (*7)/c.2921A>T	{"DPYD": {"c.2921A>T": 1, "c.295_298delTCAT (*7)": 1}}	\N
6513563	6513082	c.1682G>T/c.1774C>T	{"DPYD": {"c.1682G>T": 1, "c.1774C>T": 1}}	\N
6513564	6513082	c.1371C>T/c.2933A>G	{"DPYD": {"c.1371C>T": 1, "c.2933A>G": 1}}	\N
6513565	6513082	c.1475C>T/c.2915A>G	{"DPYD": {"c.1475C>T": 1, "c.2915A>G": 1}}	\N
6513566	6513082	c.343A>G/c.1679T>G (*13)	{"DPYD": {"c.343A>G": 1, "c.1679T>G (*13)": 1}}	\N
6513567	6513082	c.1905+1G>A (*2A)/c.2482G>A	{"DPYD": {"c.2482G>A": 1, "c.1905+1G>A (*2A)": 1}}	\N
6513568	6513082	c.1156G>T (*12)/c.2915A>G	{"DPYD": {"c.2915A>G": 1, "c.1156G>T (*12)": 1}}	\N
6513569	6513082	c.295_298delTCAT (*7)/c.1519G>A	{"DPYD": {"c.1519G>A": 1, "c.295_298delTCAT (*7)": 1}}	\N
6513570	6513082	c.1156G>T (*12)/c.2623A>C	{"DPYD": {"c.2623A>C": 1, "c.1156G>T (*12)": 1}}	\N
6513571	6513082	c.1627A>G (*5)/c.1905+1G>A (*2A)	{"DPYD": {"c.1627A>G (*5)": 1, "c.1905+1G>A (*2A)": 1}}	\N
6513572	6513082	c.1775G>A/c.2303C>A	{"DPYD": {"c.1775G>A": 1, "c.2303C>A": 1}}	\N
6513573	6513082	c.1898delC (*3)/c.3067C>A	{"DPYD": {"c.3067C>A": 1, "c.1898delC (*3)": 1}}	\N
6513574	6513082	c.1108A>G/c.2983G>T (*10)	{"DPYD": {"c.1108A>G": 1, "c.2983G>T (*10)": 1}}	\N
6513575	6513082	c.1057C>T/c.3061G>C	{"DPYD": {"c.1057C>T": 1, "c.3061G>C": 1}}	\N
6513576	6513082	c.61C>T/c.934C>T	{"DPYD": {"c.61C>T": 1, "c.934C>T": 1}}	\N
6513577	6513082	c.1475C>T/c.2623A>C	{"DPYD": {"c.1475C>T": 1, "c.2623A>C": 1}}	\N
6513578	6513082	c.929T>C/c.2983G>T (*10)	{"DPYD": {"c.929T>C": 1, "c.2983G>T (*10)": 1}}	\N
6513579	6513082	c.1774C>T/c.2161G>A	{"DPYD": {"c.1774C>T": 1, "c.2161G>A": 1}}	\N
6513580	6513082	c.1519G>A/c.2639G>T	{"DPYD": {"c.1519G>A": 1, "c.2639G>T": 1}}	\N
6513581	6513082	c.1057C>T/c.2186C>T	{"DPYD": {"c.1057C>T": 1, "c.2186C>T": 1}}	\N
6513582	6513082	c.1484A>G/c.1615G>A	{"DPYD": {"c.1484A>G": 1, "c.1615G>A": 1}}	\N
6513583	6513082	c.85T>C (*9A)/c.1905+1G>A (*2A)	{"DPYD": {"c.85T>C (*9A)": 1, "c.1905+1G>A (*2A)": 1}}	\N
6513584	6513082	c.295_298delTCAT (*7)/c.1682G>T	{"DPYD": {"c.1682G>T": 1, "c.295_298delTCAT (*7)": 1}}	\N
6513585	6513082	c.313G>A/c.2933A>G	{"DPYD": {"c.313G>A": 1, "c.2933A>G": 1}}	\N
6513586	6513082	c.1003G>T (*11)/c.1475C>T	{"DPYD": {"c.1475C>T": 1, "c.1003G>T (*11)": 1}}	\N
6513587	6513082	c.1543G>A/c.2021G>A	{"DPYD": {"c.1543G>A": 1, "c.2021G>A": 1}}	\N
6513588	6513082	c.496A>G/c.2933A>G	{"DPYD": {"c.496A>G": 1, "c.2933A>G": 1}}	\N
6513589	6513082	c.1057C>T/c.1294G>A	{"DPYD": {"c.1057C>T": 1, "c.1294G>A": 1}}	\N
6513590	6513082	c.295_298delTCAT (*7)/c.343A>G	{"DPYD": {"c.343A>G": 1, "c.295_298delTCAT (*7)": 1}}	\N
6513591	6513082	c.1898delC (*3)/c.2195T>G	{"DPYD": {"c.2195T>G": 1, "c.1898delC (*3)": 1}}	\N
6513592	6513082	c.1278G>T/c.1475C>T	{"DPYD": {"c.1278G>T": 1, "c.1475C>T": 1}}	\N
6513593	6513082	c.1898delC (*3)/c.2657G>A (*9B)	{"DPYD": {"c.1898delC (*3)": 1, "c.2657G>A (*9B)": 1}}	\N
6513594	6513082	c.1775G>A/c.3067C>A	{"DPYD": {"c.1775G>A": 1, "c.3067C>A": 1}}	\N
6513595	6513082	c.1615G>A/c.2933A>G	{"DPYD": {"c.1615G>A": 1, "c.2933A>G": 1}}	\N
6513596	6513082	c.703C>T (*8)/c.1601G>A (*4)	{"DPYD": {"c.703C>T (*8)": 1, "c.1601G>A (*4)": 1}}	\N
6513597	6513082	c.313G>A/c.601A>C	{"DPYD": {"c.313G>A": 1, "c.601A>C": 1}}	\N
6513598	6513082	c.46C>G/c.1898delC (*3)	{"DPYD": {"c.46C>G": 1, "c.1898delC (*3)": 1}}	\N
6513599	6513082	c.632A>G/c.1218G>A	{"DPYD": {"c.632A>G": 1, "c.1218G>A": 1}}	\N
6513600	6513082	c.1777G>A/c.2657G>A (*9B)	{"DPYD": {"c.1777G>A": 1, "c.2657G>A (*9B)": 1}}	\N
6513601	6513082	c.295_298delTCAT (*7)/c.1627A>G (*5)	{"DPYD": {"c.1627A>G (*5)": 1, "c.295_298delTCAT (*7)": 1}}	\N
6513602	6513082	c.295_298delTCAT (*7)/c.1601G>A (*4)	{"DPYD": {"c.1601G>A (*4)": 1, "c.295_298delTCAT (*7)": 1}}	\N
6513603	6513082	c.1777G>A/c.2195T>G	{"DPYD": {"c.1777G>A": 1, "c.2195T>G": 1}}	\N
6513604	6513082	c.703C>T (*8)/c.1627A>G (*5)	{"DPYD": {"c.703C>T (*8)": 1, "c.1627A>G (*5)": 1}}	\N
6513605	6513082	c.2021G>A/c.2582A>G	{"DPYD": {"c.2021G>A": 1, "c.2582A>G": 1}}	\N
6513606	6513082	c.498G>A/c.1905+1G>A (*2A)	{"DPYD": {"c.498G>A": 1, "c.1905+1G>A (*2A)": 1}}	\N
6513607	6513082	c.1057C>T/Reference	{"DPYD": {"Reference": 1, "c.1057C>T": 1}}	\N
6513608	6513082	c.1577C>G/c.1898delC (*3)	{"DPYD": {"c.1577C>G": 1, "c.1898delC (*3)": 1}}	\N
6513609	6513082	c.1156G>T (*12)/c.1627A>G (*5)	{"DPYD": {"c.1627A>G (*5)": 1, "c.1156G>T (*12)": 1}}	\N
6513610	6513082	c.1777G>A/c.3067C>A	{"DPYD": {"c.1777G>A": 1, "c.3067C>A": 1}}	\N
6513611	6513082	c.1898delC (*3)/c.2303C>A	{"DPYD": {"c.2303C>A": 1, "c.1898delC (*3)": 1}}	\N
