Variant selection based on an update of the CPIC guideline for potent volatile anesthetic agents and succinylcholine. The guideline update includes the published list of RYR1 variants (supplemental table S2), which are evaluated by the ClinGen malignant hyperthermia susceptibility (MHS) variant curation expert panel and classified for RYR1-related malignant hyperthermia susceptibility based on specified the ACMG/AMP criteria (PMID 35849058).