CYP2D6*2 is assigned normal function based on moderate evidence. CYP2D6*2 has consistently been described in subjects demonstrating similar metabolism with various CYP2D6 substrates compared to wildtype (7903454, 11037799, 12915955, 20456744). Although in vitro studies found CYP2D6*2 had enzyme activity ranging from similar to decreased activity compared to wildtype, the in vitro data was not convincing as the differences in results may be due to differences in the expression system used (11266079, 18784265, 24647041, 25469868, 26310775, 26542054, 26652007, 26937172, 26968424, 27203132, 27251229, 27354764, 27538917, 30366777). Therefore, consensus among experts was normal function with an activity value of 1 based on moderate evidence.