CYP2D6*114 is assigned no function based on limited evidence. CYP2D6*114 has been described in a subject with CYP2D6*5/*114 genotype demonstrating poor debrisoquine metabolism (10064570). Multiple in vitro studies found CYP2D6*114 had nondetectable enzyme activity with various substrates (18784265, 24647041). Therefore, consensus among experts was no function with an activity value of 0 based on limited evidence.