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778005	6344341	0	0.0	1
779734	6344341	\N	\N	1
778007	6344341	\N	\N	1
778009	6344341	\N	\N	1
778011	6344341	\N	\N	1
778013	6344341	0.016	0.016	1
778015	6344341	0.137	0.137	1
779740	6344341	0	0.0	1
779741	6344341	\N	\N	1
778017	6344341	\N	\N	1
778019	6344341	0.011	0.011	1
779744	6344341	\N	\N	1
778021	6344341	\N	\N	1
778023	6344341	\N	\N	1
779747	6344341	\N	\N	1
778025	6344341	\N	\N	1
778027	6344341	\N	\N	1
778029	6344341	\N	\N	1
778031	6344341	\N	\N	1
778033	6344341	\N	\N	1
778035	6344341	\N	\N	1
778037	6344341	\N	\N	1
778039	6344341	\N	\N	1
778041	6344341	\N	\N	1
778043	6344341	\N	\N	1
778045	6344341	\N	\N	1
778049	6344341	0.006	0.006	1
778051	6344341	\N	\N	1
778053	6344341	\N	\N	1
778055	6344341	\N	\N	1
778057	6344341	\N	\N	1
778059	6344341	\N	\N	1
778061	6344341	\N	\N	1
778063	6344341	\N	\N	1
778065	6344341	\N	\N	1
778067	6344341	\N	\N	1
778069	6344341	\N	\N	1
778071	6344341	\N	\N	1
778073	6344341	\N	\N	1
778075	6344341	\N	\N	1
778077	6344341	\N	\N	1
778079	6344341	\N	\N	1
778081	6344341	\N	\N	1
778083	6344341	\N	\N	1
778085	6344341	\N	\N	1
778087	6344341	\N	\N	1
778089	6344341	\N	\N	1
778091	6344341	\N	\N	1
778093	6344341	\N	\N	1
778095	6344341	\N	\N	1
778097	6344341	\N	\N	1
778099	6344341	\N	\N	1
778101	6344341	\N	\N	1
778103	6344341	\N	\N	1
778105	6344341	\N	\N	1
778107	6344341	\N	\N	1
778109	6344341	\N	\N	1
778111	6344341	\N	\N	1
778113	6344341	\N	\N	1
778115	6344341	\N	\N	1
778117	6344341	\N	\N	1
778119	6344341	\N	\N	1
778121	6344341	\N	\N	1
778123	6344341	\N	\N	1
778125	6344341	\N	\N	1
778127	6344341	\N	\N	1
778129	6344341	\N	\N	1
778131	6344341	\N	\N	1
778133	6344341	\N	\N	1
778135	6344341	\N	\N	1
778137	6344341	\N	\N	1
778139	6344341	\N	\N	1
778141	6344341	\N	\N	1
778143	6344341	\N	\N	1
778145	6344341	\N	\N	1
778147	6344341	\N	\N	1
778149	6344341	\N	\N	1
778151	6344341	\N	\N	1
778153	6344341	\N	\N	1
778155	6344341	\N	\N	1
778157	6344341	\N	\N	1
778159	6344341	\N	\N	1
778161	6344341	\N	\N	1
778163	6344341	\N	\N	1
778165	6344341	\N	\N	1
778167	6344341	\N	\N	1
778169	6344341	\N	\N	1
778171	6344341	\N	\N	1
778173	6344341	\N	\N	1
778175	6344341	\N	\N	1
778177	6344341	\N	\N	1
778179	6344341	\N	\N	1
778181	6344341	\N	\N	1
778183	6344341	\N	\N	1
778185	6344341	\N	\N	1
778187	6344341	\N	\N	1
778189	6344341	\N	\N	1
778191	6344341	\N	\N	1
778193	6344341	\N	\N	1
778195	6344341	\N	\N	1
778197	6344341	\N	\N	1
778199	6344341	\N	\N	1
778201	6344341	\N	\N	1
778203	6344341	\N	\N	1
778205	6344341	\N	\N	1
778207	6344341	\N	\N	1
778209	6344341	\N	\N	1
1103378	6344341	\N	\N	1
2955640	6344341	\N	\N	1
1103380	6344341	\N	\N	1
1609528	6344341	\N	\N	1
1103382	6344341	\N	\N	1
2091237	6344341	\N	\N	1
2091239	6344341	\N	\N	1
2091241	6344341	\N	\N	1
2091243	6344341	\N	\N	1
2091245	6344341	\N	\N	1
2091247	6344341	\N	\N	1
2091249	6344341	\N	\N	1
\.


--
-- Data for Name: allele_location_value; Type: TABLE DATA; Schema: cpic; Owner: -
--

COPY cpic.allele_location_value (alleledefinitionid, locationid, variantallele, version) FROM stdin;
1508724	1508723	G	1
1508726	1508723	T	1
828095	828071	A	1
828095	828072	T	1
828095	828073	A	1
828095	828074	G	1
828095	896589	A	1
828095	828077	A	1
828095	828078	A	1
828095	828079	A	1
828095	828080	A	1
828095	828081	G	1
828095	896595	C	1
828095	896596	T	1
828095	1104230	T	1
828095	828086	G	1
828095	828087	T	1
828095	828088	T	1
828095	828089	T	1
828095	828090	C	1
828095	828091	T	1
828095	828092	C	1
828095	828093	A	1
828095	828094	C	1
3827872	828071	G	1
3827874	828072	C	1
3827876	828073	G	1
3827878	828074	A	1
3827880	896589	C	1
3827882	896589	G	1
3827884	828077	G	1
3827886	828078	G	1
3827888	828079	G	1
3827890	828080	G	1
3827892	828081	A	1
3827894	896595	delC	1
3827896	896596	G	1
3827898	1104230	delT	1
3827900	1104230	delinsCC; delinsCCC; delinsCCCC; delinsCCCCC; delinsCCCCCC; delinsCCCCCCC	1
3827902	828086	A	1
3827904	828087	C	1
3827906	828088	C	1
3827908	828089	C	1
3827910	828090	T	1
3827912	828091	C	1
3827914	828092	T	1
3827916	828093	G	1
3827918	828094	T	1
779392	779349	T	1
779392	779350	A	1
779392	779351	T	1
779392	779352	del	1
779392	779353	C	1
779392	779354	G	1
779392	779355	A	1
779392	779356	A	1
779392	779357	G	1
779392	779358	C	1
779392	779359	G	1
779392	779360	C	1
779392	779361	C	1
779392	779362	G	1
779392	779363	C	1
779392	779364	A	1
779392	779365	C	1
779392	779366	C	1
779392	779367	T	1
779392	779368	T	1
779392	779369	G	1
779392	779370	C	1
779392	779371	C	1
779392	779372	C	1
779392	779373	G	1
779392	779374	C	1
779392	779375	C	1
779392	779376	T	1
779392	779377	G	1
779392	779378	A	1
779392	779379	C	1
779392	779380	T	1
779392	779381	C	1
779392	779382	A	1
779392	779383	A	1
779392	779384	C	1
779392	779385	A	1
779392	779386	C	1
779392	779387	A	1
779392	779388	C	1
779392	779389	A	1
779392	779390	T	1
779392	779391	T	1
779394	779361	G	1
779396	779372	T	1
779396	779391	C	1
779398	779372	T	1
779400	779391	C	1
779402	779384	T	1
779404	779355	G	1
779406	779380	A	1
779408	779389	C	1
779410	779386	T	1
779412	779367	G	1
779414	779371	G	1
779416	779370	T	1
779418	779369	A	1
779420	779351	A	1
779422	779349	C	1
779424	779375	T	1
779426	779374	T	1
779428	779354	C	1
779430	779358	T	1
779432	779368	G	1
779434	779390	C	1
779436	779357	C	1
779438	779374	G	1
779440	779377	C	1
779442	779379	A	1
779444	779385	G	1
779446	779383	G	1
779448	779364	C	1
779450	779366	G	1
779452	779350	G	1
779454	779353	T	1
779456	779382	G	1
779458	779365	T	1
779460	779373	A	1
779462	779362	A	1
779464	779356	G	1
779466	779381	T	1
779468	779387	T	1
779470	779378	G	1
779472	779359	A	1
779474	779388	T	1
779476	779391	G	1
779478	779352	insT	1
779480	779360	A	1
779480	779363	T	1
779482	779376	C	1
777262	777260	G	1
777262	777261	C	1
777264	777260	A	1
777266	777261	T	1
779064	779045	T	1
779064	779046	G	1
779064	949529	GAGTCG(3)	1
779064	779048	G	1
779064	779050	del	1
779064	779051	C	1
779064	779052	G	1
779064	779053	A	1
779064	779054	G	1
779064	779055	C	1
779064	949537	A	1
779064	949538	G	1
779064	779058	G	1
779064	779059	C	1
779064	5881932	G	1
779064	779060	C	1
779064	779061	G	1
779064	779062	T	1
779066	949529	GAGTCG(4)	1
779066	779060	T	1
779068	779060	T	1
779070	779061	A	1
779072	779048	A	1
779074	949529	GAGTCG(4)	1
779076	779052	C	1
779078	779053	G	1
779080	949529	GAGTCG(2)	1
779082	779045	C	1
779084	779054	A	1
779086	779055	G	1
779088	949538	GG	1
779090	779050	insCGGG	1
779092	779062	A	1
779094	779051	T	1
779096	779058	T	1
779098	949537	delA	1
779100	779046	C	1
779102	779059	G	1
5881976	5881932	C	1
779488	779484	C	1
779488	1000510	TA(7)	1
779488	779486	G	1
779488	779487	C	1
779490	779486	A	1
779492	779487	A	1
779494	1000510	TA(8)	1
779496	1000510	TA(6)	1
779498	1000510	TA(9)	1
779500	779484	T	1
779502	779484	T	1
779502	1000510	TA(8)	1
779504	779484	T	1
779504	1000510	TA(9)	1
777307	777268	G	1
777307	777269	C	1
777307	777270	C	1
777307	777271	C	1
777307	777272	G	1
777307	777273	C	1
777307	777274	G	1
777307	777275	G	1
777307	777276	G	1
777307	777303	A	1
777307	777277	T	1
777307	777278	G	1
777307	777279	G	1
777307	777280	C	1
777307	777281	G	1
777307	777282	A	1
777307	777283	T	1
777307	777284	G	1
777307	777285	G	1
777307	777286	A	1
777307	777287	G	1
777307	777304	G	1
777307	777288	C	1
777307	777289	C	1
777307	777305	A	1
777307	777290	T	1
777307	777291	A	1
777307	777292	G	1
777307	777293	G	1
777307	777294	G	1
777307	777295	C	1
777307	777296	T	1
777307	777297	G	1
777307	777306	C	1
777307	777298	G	1
777307	777299	G	1
777307	777300	T	1
777307	777301	G	1
777307	777302	G	1
777333	777268	A	1
777357	777269	T	1
777371	777270	T	1
777321	777271	A	1
777323	777272	C	1
777363	777273	T	1
777365	777274	A	1
777347	777275	A	1
777331	777276	A	1
777315	777303	G	1
777355	777277	G	1
777367	777278	A	1
777369	777279	A	1
777319	777280	A	1
777377	777281	A	1
777379	777282	C	1
777381	777283	G	1
777351	777284	A	1
777349	777285	A	1
777329	777286	G	1
777335	777287	T	1
777309	777304	A	1
777383	777288	T	1
777385	777289	T	1
777311	777305	G	1
777337	777290	G	1
777353	777291	C	1
777317	777292	A	1
777341	777293	A	1
777359	777294	A	1
777361	777295	T	1
777339	777296	A	1
777325	777297	C	1
777313	777306	T	1
777343	777298	A	1
777373	777299	A	1
777375	777300	C	1
777327	777301	A	1
777345	777302	A	1
779148	3684990	T	1
779148	3684991	TGA	1
779148	3684992	A	1
779148	779104	T	1
779148	3684994	G	1
779148	779105	C	1
779148	3684996	G	1
779148	3684997	C	1
779148	3684998	G	1
779148	3684999	T	1
779148	3685000	C	1
779148	3685001	C	1
779148	3685002	G	1
779148	3685003	C	1
779148	3685004	C	1
779148	3685005	G	1
779148	3685006	A	1
779148	779106	C	1
779148	3685008	G	1
779148	3685009	G	1
779148	3685010	G	1
779148	3685011	A	1
779148	3685012	G	1
779148	3685013	G	1
779148	3685014	C	1
779148	3685015	A	1
779148	3685016	G	1
779148	3685017	C	1
779148	3685018	G	1
779148	3685019	T	1
779148	3685020	A	1
779148	3685021	G	1
779148	3685022	C	1
779148	3685023	G	1
779148	779109	C	1
779148	3685025	del	1
779148	779110	G	1
779148	3685027	G	1
779148	3685028	G	1
779148	3685029	C	1
779148	3685030	C	1
779148	3685031	G	1
779148	779112	C	1
779148	3685033	C	1
779148	3685034	G	1
779148	3685035	A	1
779148	3685036	C	1
779148	3685037	T	1
779148	3685038	G	1
779148	3685039	T	1
779148	3685040	A	1
779148	779114	G	1
779148	3685042	C	1
779148	779116	G	1
779148	3824632	T	1
779148	3685046	G	1
779148	779117	C	1
779148	3685048	G	1
779148	779118	C	1
779148	779119	G	1
779148	3685051	G	1
779148	3685052	G	1
779148	3685053	C	1
779148	3685054	C	1
779148	3685055	G	1
779148	3685056	G	1
779148	3685057	G	1
779148	3685058	G	1
779148	3685059	G	1
779148	3685060	C	1
779148	3824648	G	1
779148	3685063	G	1
779148	3685064	G	1
779148	3685065	C	1
779148	3685066	C	1
779148	3685067	A	1
779148	3685068	G	1
779148	3685069	A	1
779148	3685070	A	1
779148	3685071	A	1
779148	3685072	A	1
779148	3685073	C	1
779148	3685074	C	1
779148	3685075	C	1
779148	3685076	T	1
779148	3685077	A	1
779148	3685078	G	1
779148	3685079	A	1
779148	3685080	C	1
779148	3685081	T	1
779148	3685082	C	1
779148	3685083	T	1
779148	3685084	C	1
779148	3685085	A	1
779148	3685086	T	1
779148	3685087	C	1
779148	3685088	A	1
779148	3685089	G	1
779148	3685090	T	1
779148	3685091	G	1
779148	3685092	G	1
779148	3685093	G	1
779148	3685094	C	1
779148	3685095	G	1
779148	3685096	G	1
779148	779120	C	1
779148	3685098	G	1
777422	777387	T	1
777422	777388	A	1
777422	777389	C	1
777422	777390	A	1
777422	777391	A	1
777422	777392	C	1
777422	777393	G	1
777422	777394	A	1
777422	777395	T	1
777422	777396	G	1
777422	2899031	G	1
777422	777397	G	1
777422	777398	T	1
777422	777399	A	1
777422	2899035	C	1
777422	777400	G	1
777422	777401	G	1
777422	5997181	G	1
777422	777402	C	1
777422	777403	C	1
777422	777404	G	1
777422	2899041	G	1
777422	777417	T	1
777422	777405	T	1
777422	2899044	A	1
777422	777406	C	1
777422	777407	A	1
777422	777408	G	1
777422	777409	C	1
777422	777420	C	1
777422	777410	T	1
777422	777411	C	1
777422	2899052	T	1
777422	2899053	A	1
777422	777412	C	1
777422	2899055	G	1
777422	2899056	T	1
777422	2899057	T	1
777422	777413	T	1
777422	777421	G	1
777422	777414	C	1
777422	2899061	G	1
777422	2899062	G	1
777422	777415	A	1
777422	2899064	G	1
777422	777418	G	1
777422	777419	A	1
777422	1102587	C	1
777424	777389	T	1
777426	777406	A	1
777428	777407	G	1
777430	1102587	T	1
777432	777404	T	1
777432	777407	G	1
777434	777404	T	1
777434	777407	G	1
777434	1102587	T	1
777436	777399	G	1
777438	777404	T	1
777440	777388	T	1
777440	777389	T	1
777442	777394	G	1
777444	777396	A	1
777446	777399	G	1
777446	777404	T	1
777446	777407	G	1
777448	777400	A	1
777450	777413	A	1
777452	777390	T	1
777452	777391	G	1
777452	777392	A	1
777452	777393	C	1
777454	777407	R	1
777454	777410	C	1
777456	777404	T	1
777456	777407	G	1
777456	777411	T	1
777458	777403	T	1
777458	777404	T	1
777458	777407	G	1
777460	777414	A	1
777462	777387	C	1
777464	777415	G	1
777466	777418	A	1
777468	777419	T	1
777470	777402	G	1
777470	777404	T	1
777470	777407	G	1
777472	777405	C	1
777474	777409	G	1
777474	777412	T	1
777480	777420	A	1
777482	777421	A	1
777484	1102587	A	1
777486	777387	C	1
777486	777404	T	1
777486	777407	G	1
777486	1102587	A	1
777488	777387	C	1
777488	777397	T	1
777488	777398	C	1
777488	777401	T	1
777488	777405	C	1
777488	777408	C	1
777490	777387	C	1
777490	777404	T	1
777490	777407	G	1
777492	777404	T	1
777492	777417	G	1
777492	777407	G	1
777494	777395	A	1
777494	777404	T	1
777494	777407	G	1
2899142	2899035	T	1
2899142	777404	T	1
2899142	777407	G	1
2899144	777404	T	1
2899144	777407	G	1
2899144	2899055	A	1
2899146	777404	T	1
2899146	777407	G	1
2899146	2899056	C	1
2899148	777404	T	1
2899148	777407	G	1
2899148	2899062	A	1
2899150	777404	T	1
2899150	777407	G	1
2899150	2899064	A	1
2899152	2899031	A	1
2899154	2899041	A	1
2899156	2899044	C	1
2899158	2899052	C	1
2899158	2899053	G	1
2899160	2899057	A	1
2899162	2899061	A	1
5997308	777387	C	1
5997308	5997181	A	1
779148	779122	G	1
779148	3685100	A	1
779148	3685101	G	1
779148	3685102	C	1
779148	3685103	C	1
779148	779123	C	1
779148	3685105	G	1
779148	3685106	T	1
779148	3685107	G	1
779148	3685108	G	1
779148	3685109	C	1
779148	3685110	G	1
779148	3685111	C	1
779148	3685112	G	1
779148	3685113	C	1
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779148	3685115	A	1
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779148	779124	G	1
779148	3685118	T	1
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779148	3685120	G	1
779148	3685121	C	1
779148	3685122	G	1
779148	779125	GAG	1
779148	3685124	A	1
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779148	3685126	G	1
779148	779127	C	1
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777530	777496	C	1
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777530	777499	T	1
777530	777500	T	1
777530	777501	A	1
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777530	777503	A	1
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777530	777505	C	1
777530	777506	G	1
777530	777507	A	1
777530	777508	A	1
777530	777509	T	1
777530	777510	A	1
777530	777511	G	1
777530	777512	G	1
777530	777513	G	1
777530	6234974	A	1
777530	777514	G	1
777530	777515	G	1
777530	777516	G	1
777530	777517	C	1
777530	777518	G	1
777530	777519	G	1
777530	777520	T	1
777530	777521	G	1
777530	777522	A	1
777530	777523	G	1
777530	777524	G	1
777530	777525	C	1
777530	777526	C	1
777530	777527	C	1
777530	777528	C	1
777530	777529	A	1
777532	777522	G	1
777534	777508	G	1
777534	777513	R	1
777534	777518	A	1
777534	777522	G	1
777536	777516	A	1
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777538	777496	Y	1
777538	777497	G	1
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777540	777522	G	1
777540	777526	T	1
777542	777511	A	1
777542	777522	G	1
777544	777520	A	1
777544	777522	G	1
777546	777509	C	1
777546	777522	G	1
777548	777512	A	1
777548	777522	G	1
777550	777517	T	1
777550	777522	G	1
777552	777513	A	1
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777554	777522	G	1
777554	777529	C	1
777556	777522	G	1
777556	777525	T	1
777558	777500	C	1
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777560	777501	C	1
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777562	777527	T	1
777564	777496	T	1
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777566	777521	A	1
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777568	777503	G	1
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777570	777514	C	1
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777572	777506	C	1
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777576	777522	G	1
777576	777528	G	1
777578	777519	A	1
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777580	777501	C	1
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777580	777524	A	1
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777584	777504	T	1
777586	777505	T	1
777586	777522	G	1
777588	777507	G	1
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777590	777515	A	1
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777592	777498	T	1
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777594	777501	M	1
777594	777508	G	1
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777600	777501	C	1
777600	777510	C	1
777600	777522	G	1
6235063	777498	T	1
6235063	777499	C	1
6235063	777522	G	1
6235065	6234974	G	1
6235065	777522	G	1
779148	3685147	G	1
779148	3685148	C	1
779148	3685149	G	1
779148	779132	C	1
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779148	3685152	T	1
779148	779133	C	1
779148	779134	G	1
779148	779135	C	1
779148	3685156	G	1
779148	3685157	C	1
779148	3685158	C	1
779148	779137	C	1
779148	779138	G	1
779148	3685161	T	1
779148	3685162	A	1
779148	3685163	C	1
779148	3685164	C	1
779148	3685165	G	1
779148	3685166	C	1
779148	3685167	T	1
779148	3685168	G	1
779148	3685169	G	1
779148	3685170	C	1
779148	3685171	C	1
779148	3685172	G	1
779148	3685173	A	1
779148	3685174	G	1
779148	3685175	G	1
779148	3685176	C	1
779148	3685177	C	1
779148	3685178	C	1
779148	3685179	T	1
779148	3685180	T	1
779148	3685181	G	1
779148	3685182	C	1
779148	3685183	C	1
779148	3685184	C	1
779148	3685185	G	1
779148	3685186	G	1
779148	779139	G	1
779148	3685188	G	1
779148	3685189	C	1
779148	3685190	A	1
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779148	3685192	G	1
779148	3685193	G	1
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779148	3685196	G	1
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779148	3685198	G	1
779148	3685199	C	1
779148	3685200	G	1
779148	3685201	G	1
779148	3685202	A	1
779148	3685203	C	1
779148	3685204	A	1
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779148	3685206	C	1
779148	3685207	G	1
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779148	3685213	C	1
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779148	3685216	G	1
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779148	3685219	G	1
779148	3685220	G	1
779148	3685221	A	1
779148	3685222	T	1
777668	777602	A	1
777668	1932756	T	1
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777668	1932760	G	1
777668	777605	A	1
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777668	777609	T	1
777668	1932766	G	1
777668	777610	G	1
777668	777611	G	1
777668	777612	T	1
777668	948023	AGAAATGGAA	1
777668	777614	A	1
777668	777615	C	1
777668	777616	G	1
777668	777617	C	1
777668	777618	G	1
777668	6235088	C	1
777668	1932776	T	1
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777668	777621	G	1
777668	777622	C	1
777668	777623	G	1
777668	777624	G	1
777668	1406126	C	1
777668	1406127	C	1
777668	777625	G	1
777668	777626	C	1
777668	777627	C	1
777668	777628	A	1
777668	777629	A	1
777668	777630	T	1
777668	777631	A	1
777668	1985225	G	1
777668	777632	A	1
777668	777633	C	1
777668	1932795	C	1
777668	1932796	T	1
777668	6235110	T	1
777668	777634	A	1
777668	777635	A	1
777668	948046	A	1
777668	777637	C	1
777668	777638	C	1
777668	777639	A	1
777668	777640	A	1
777668	777641	C	1
777668	1932805	A	1
777668	6235120	A	1
777668	777642	C	1
777668	777643	G	1
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777668	777645	C	1
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777668	777647	C	1
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777668	1932813	C	1
777668	777649	G	1
777668	777650	A	1
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777668	777653	C	1
777668	777654	C	1
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777668	777656	G	1
777668	777657	A	1
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777668	1406163	A	1
777668	1932825	G	1
777668	777659	C	1
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777668	777666	C	1
777668	777667	G	1
777670	777622	T	1
777672	777650	C	1
777674	777651	C	1
777676	777652	G	1
777678	948046	delA	1
777680	777603	A	1
777682	777625	A	1
777684	777634	G	1
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777688	777645	T	1
777690	777666	T	1
777692	777609	C	1
777694	777618	A	1
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777698	777640	G	1
777700	777655	T	1
777702	777650	C	1
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777704	777662	C	1
777706	777607	C	1
777708	777604	T	1
777710	777605	G	1
777712	777608	A	1
777714	777649	A	1
777716	948023	delAGAAATGGAA	1
777718	777619	G	1
777720	777625	T	1
777722	777631	T	1
777724	777637	A	1
777726	777665	A	1
777728	777644	C	1
777730	777667	T	1
777732	777621	A	1
777734	777646	A	1
777736	777618	T	1
777736	777622	T	1
777738	777602	G	1
777738	777652	S	1
777740	777606	G	1
777742	777610	C	1
777744	777611	T	1
777746	777612	C	1
777748	777614	G	1
777750	777616	A	1
777752	777615	T	1
777754	777619	T	1
777756	777620	T	1
777758	777624	A	1
777760	777627	T	1
777762	777630	C	1
777764	777632	G	1
777766	777633	T	1
777768	777639	G	1
777770	777641	G	1
777772	777642	T	1
777774	777648	A	1
777776	777653	A	1
777778	777657	G	1
777780	777629	C	1
777782	777647	A	1
777784	777660	T	1
777786	777664	C	1
777788	777622	T	1
777788	777663	G	1
777790	777617	T	1
777792	777623	A	1
777794	777638	G	1
777796	777643	T	1
777798	777654	G	1
777800	777659	T	1
777802	777650	C	1
777802	777656	A	1
777804	777628	G	1
777806	777661	T	1
777808	777635	G	1
777808	777666	T	1
1406315	1406126	T	1
1406317	1406127	T	1
1406319	1985225	T	1
1406321	1406163	C	1
1932985	1932760	A	1
1932987	1932766	A	1
1932989	1932776	G	1
1932991	1932813	T	1
1932993	1932756	G	1
1932995	1932805	T	1
1932997	1932795	T	1
1932999	1932759	T	1
1933001	1932825	C	1
1933003	1932796	delT	1
6235320	6235110	C	1
6235322	6235120	C	1
6235324	6235088	T	1
779148	3685223	A	1
779148	3685224	G	1
779148	3685225	C	1
779148	3685226	T	1
779148	3685227	C	1
779148	779140	G	1
779148	3685229	G	1
779148	3685230	A	1
777936	777935	C	1
777936	777934	G	1
777936	777933	C	1
777936	3819813	G	1
777936	3819812	A	1
777936	777932	G	1
777936	777931	C	1
777936	3819809	A	1
777936	777930	A	1
777936	777929	C	1
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777936	777927	T	1
777936	777926	G	1
777936	777925	C	1
777936	3819802	A	1
777936	1103089	AGTGGGCAC	1
777936	777923	T	1
777936	777922	G	1
777936	3819798	C	1
777936	777921	G	1
777936	777920	G	1
777936	2090937	C	1
777936	777919	C	1
777936	777918	C	1
777936	777917	C	1
777936	777916	G	1
777936	777915	C	1
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777936	777913	G	1
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777936	777911	C	1
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777936	1103074	AG	1
777936	777906	C	1
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777936	777904	C	1
777936	777903	A	1
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777936	3307484	AC	1
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777936	777897	C	1
777936	777896	G	1
777936	5997713	G	1
777936	777894	C	1
777936	2090910	T	1
777936	777893	C	1
777936	777892	T	1
777936	777891	C	1
777936	777890	T	1
777936	777889	C	1
777936	5763442	C	1
777936	777888	C	1
777936	777887	C	1
777936	5997724	G	1
777936	1103051	CACATCCGGATGTAGGATC	1
777936	777886	C	1
777936	777885	T	1
777936	777883	T	1
777936	777882	A	1
777936	777881	T	1
777936	777880	G	1
777936	1103046	G	1
777936	777878	T	1
777936	1103044	TCT	1
777936	777876	A	1
777936	777875	C	1
777936	1103041	TCAG(2)	1
777936	2090890	A	1
777936	777872	G	1
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777936	1103040	G	1
777936	777870	G	1
777936	1103036	T	1
777936	1103035	TTAG	1
777936	777867	T	1
777936	777866	C	1
777936	777865	A	1
777936	2676652	GGA(2)	1
777936	777864	G	1
777936	5997750	C	1
777936	2090878	G	1
777936	777863	C	1
777936	1103029	G	1
777936	2090875	C	1
777936	777861	A	1
777936	1609173	R	1
777936	1103027	C	1
777936	2676644	C	1
777936	777859	C	1
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777936	5997761	C	1
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777936	777857	A	1
777936	777856	del	1
777936	2676638	T	1
777936	2676637	C	1
777936	1355509	AAAGGGGCG	1
777936	777854	C	1
777936	3619338	C	1
777936	777852	A	1
777936	777851	G	1
777936	777850	T	1
777936	2090861	G	1
777936	777849	C	1
777936	777848	T	1
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777936	1103013	A	1
777936	777845	G	1
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777936	777839	C	1
777936	2090849	A	1
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777936	777837	C	1
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777936	2090845	C	1
777936	2676613	T	1
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777936	777828	T	1
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777936	777825	C	1
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777936	5997804	G	1
777936	777823	A	1
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777936	2090829	G	1
777936	1102986	A	1
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777936	777818	C	1
777936	2090825	G	1
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777936	777815	C	1
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777936	1102979	G	1
777936	777812	C	1
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777936	5175073	T	1
777938	777933	G	1
777938	777880	A	1
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777940	1103036	delT	1
777940	777850	Y	1
777942	777933	S	1
777942	3819813	R	1
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777942	777932	S	1
777942	777931	Y	1
777942	3819809	R	1
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777942	777926	R	1
777942	3819802	R	1
777942	777923	Y	1
777942	777922	S	1
777942	3819798	S	1
777942	777901	Y	1
777942	777880	R	1
777942	777854	T	1
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777942	777828	Y	1
777942	777827	K	1
777942	777817	R	1
777946	777933	S	1
777946	1103013	delA	1
777948	777885	G	1
777950	777933	G	1
777950	777880	A	1
777950	3619338	A	1
777950	777842	G	1
777952	1103044	delTCT	1
777954	777933	G	1
777954	777842	G	1
777954	777817	A	1
777956	777933	G	1
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777962	777933	G	1
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777962	3619338	T	1
777962	777842	G	1
777964	1102986	AA	1
777964	777815	Y	1
777966	777933	G	1
777966	777880	A	1
777966	777842	G	1
777966	777832	A	1
777968	1103089	AGTGGGCACAGTGGGCAC	1
777970	777933	S	1
777970	777880	R	1
777970	1103035	delTTAG	1
777970	777842	S	1
777972	777933	G	1
777972	777880	A	1
777972	777861	G	1
777972	1609173	A	1
777972	1103027	CC	1
777972	777842	G	1
777974	777933	S	1
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779184	779119	T	1
3685452	3685051	C	1
3685454	3685052	A	1
3685456	3685053	T	1
3685458	3685054	T	1
3685460	3685055	A	1
3685462	3685056	A	1
3685464	3685057	A	1
3685466	3685058	A	1
3685468	3685059	A	1
3685470	3685060	T	1
3685472	3824648	C	1
3685474	3824648	A	1
3685476	3685063	A	1
3685478	3685064	A	1
3685480	3685065	T	1
3685482	3685066	T	1
3685484	3685067	C	1
3685486	3685068	A	1
3685488	3685069	G	1
3685490	3685070	G	1
3685492	3685071	G	1
3685494	3685072	G	1
3685496	3685073	T	1
3685498	3685074	T	1
3685500	3685075	T	1
3685502	3685076	C	1
3685504	3685077	G	1
3685506	3685078	A	1
3685508	3685079	G	1
3685510	3685080	T	1
3685512	3685081	G	1
3685514	3685082	T	1
778238	2784565	G	1
778238	6235852	G	1
778238	4058570	T	1
778238	3318569	C	1
778238	6235855	G	1
778238	778237	C	1
778238	3318567	G	1
778238	3318566	C	1
778238	2784563	C	1
778238	6235860	G	1
778238	6235861	G	1
778238	3318564	C	1
778238	6235863	C	1
778238	3318563	G	1
778238	6235865	T	1
778238	3318562	G	1
778238	3318561	C	1
778238	3318560	G	1
778238	2784562	C	1
778238	778236	A	1
778240	778236	C	1
778242	778237	T	1
2784572	778237	T	1
2784572	778236	C	1
2784574	2784565	T	1
2784576	2784563	A	1
2784578	2784562	G	1
3318585	3318560	A	1
3318587	3318561	T	1
3318589	3318562	T	1
3318591	3318563	A	1
3318593	3318564	T	1
3318595	3318566	A	1
3318597	3318567	C	1
3318599	3318569	T	1
4058604	4058570	C	1
6235905	6235863	T	1
6235907	6235852	C	1
6235909	6235860	A	1
6235911	6235855	A	1
6235913	778237	T	1
6235913	6235865	C	1
6235915	2784565	T	1
6235915	6235861	A	1
3685516	3685083	C	1
3685518	3685084	T	1
3685520	3685085	G	1
3685522	3685086	A	1
3685524	3685087	T	1
3685526	3685088	C	1
3685528	3685089	T	1
3685530	3685090	A	1
3685532	3685091	C	1
3685534	3685092	C	1
3685536	3685093	A	1
3685538	3685094	G	1
3685540	3685095	A	1
3685542	3685096	A	1
779186	779120	T	1
779188	3685098	A	1
3685548	3685098	C	1
3685550	3685098	T	1
779190	779122	A	1
3685554	3685100	T	1
3685556	3685101	A	1
3685558	3685102	T	1
3685560	3685103	G	1
779192	779123	G	1
779194	779123	T	1
3685566	3685105	T	1
3685568	3685106	A	1
3685570	3685107	A	1
3685572	3685108	A	1
3685574	3685109	T	1
3685576	3685110	A	1
3685578	3685111	T	1
3685580	3685112	A	1
3685582	3685113	T	1
3685584	3685114	A	1
3685586	3685115	C	1
3685588	3685116	G	1
779196	779124	A	1
3685592	3685118	C	1
3685594	3685119	G	1
3685596	3685120	C	1
3685598	3685121	A	1
3685600	3685122	A	1
779198	779125	delGAG	1
3685604	3685124	G	1
779200	779126	A	1
3685608	3685126	A	1
779202	779127	T	1
3685612	3685128	A	1
3685614	3685129	A	1
3685616	3685130	T	1
3685618	3685131	A	1
3685620	3685132	G	1
3685622	3685133	G	1
3685624	3685134	G	1
3685626	3685135	G	1
3685628	3685136	A	1
3685630	3685137	G	1
3685632	3685138	A	1
779204	779128	C	1
3685636	3685140	G	1
3685638	3685141	A	1
779206	779129	A	1
3685642	3685143	A	1
3685644	3685143	T	1
3685646	3685144	T	1
779208	779130	A	1
779210	3685146	A	1
3685652	3685146	T	1
3685654	3685147	A	1
3685656	3685148	T	1
3685658	3685149	C	1
779212	779132	T	1
3685662	3685151	A	1
3685664	3685151	C	1
3685666	3685152	C	1
779214	779133	T	1
779216	779134	A	1
779218	779135	T	1
779220	3685156	A	1
3685676	3685156	T	1
3685678	3685157	T	1
3685680	3685158	T	1
779222	779137	T	1
779224	779137	G	1
779226	779138	A	1
3685688	3685161	C	1
3685690	3685162	G	1
3685692	3685163	G	1
3685694	3685163	T	1
3685696	3685164	G	1
3685698	3685165	A	1
3685700	3685166	T	1
3685702	3685167	A	1
3685704	3685168	C	1
3685706	3685168	A	1
3685708	3685169	A	1
3685710	3685170	T	1
3685712	3685171	T	1
3685714	3685172	C	1
3685716	3685173	G	1
3685718	3685174	A	1
3685720	3685175	A	1
3685722	3685176	T	1
3685724	3685177	G	1
3685726	3685178	T	1
3685728	3685179	C	1
3685730	3685180	A	1
3685732	3685181	A	1
3685734	3685182	G	1
3685736	3685183	T	1
3685738	3685184	T	1
3685740	3685185	A	1
3685742	3685186	A	1
779228	779139	A	1
3685746	3685188	A	1
3685748	3685189	T	1
3685750	3685190	G	1
3685752	3685191	C	1
3685754	3685192	A	1
3685756	3685193	C	1
3685758	3685194	C	1
3685760	3685195	C	1
3685762	3685196	A	1
3685764	3685197	A	1
3685766	3685198	A	1
3685768	3685199	T	1
3685770	3685200	A	1
3685772	3685201	A	1
3685774	3685202	G	1
3685776	3685203	A	1
3685778	3685204	T	1
3685780	3685205	G	1
3685782	3685206	T	1
3685784	3685207	A	1
3685786	3685208	C	1
3685788	3685209	C	1
3685790	3685210	T	1
3685792	3685211	C	1
3685794	3685212	T	1
3685796	3685213	T	1
778327	778244	G	1
778327	778245	G	1
778327	778246	C	1
778327	778247	A	1
778327	948658	ATGA(2)	1
778327	778249	C	1
778327	778250	T	1
778327	778251	T	1
778327	778252	T	1
778327	778253	C	1
778327	778254	C	1
778327	778255	T	1
778327	778256	T	1
778327	778257	T	1
778327	778258	G	1
778327	778259	T	1
778327	778260	T	1
778327	778261	A	1
778327	778262	G	1
778327	778263	C	1
778327	778264	C	1
778327	778265	C	1
778327	778266	G	1
778327	778267	T	1
778327	778268	G	1
778327	778270	C	1
778327	778271	G	1
778327	778272	C	1
778327	778273	C	1
778327	778269	C	1
778327	778274	A	1
778327	778275	C	1
778327	778276	C	1
778327	778277	A	1
778327	778278	G	1
778327	778279	G	1
778327	778280	G	1
778327	778281	G	1
778327	778282	G	1
778327	778283	T	1
778327	778284	C	1
778327	778285	C	1
778327	778286	G	1
778327	778287	C	1
778327	778288	C	1
778327	778289	T	1
778327	778290	A	1
778327	778291	C	1
778327	778292	G	1
778327	778293	C	1
778327	778294	C	1
778327	778295	A	1
778327	778296	A	1
778327	948707	G	1
778327	778298	G	1
778327	778299	C	1
778327	778300	T	1
778327	778301	C	1
778327	778302	C	1
778327	778303	C	1
778327	778304	G	1
778327	778305	C	1
778327	778306	A	1
778327	778307	G	1
778327	778308	G	1
778327	778309	G	1
778327	778310	C	1
778327	778311	T	1
778327	778312	T	1
778327	778313	C	1
778327	778314	G	1
778327	778315	C	1
778327	778316	T	1
778327	778317	T	1
778327	778318	T	1
778327	778319	T	1
778327	778320	T	1
778327	778322	G	1
778327	778321	A	1
778327	778323	C	1
778327	778324	C	1
778327	778325	C	1
778327	778326	G	1
778329	778244	C	1
778331	778245	A	1
778333	778246	T	1
778335	778247	G	1
778337	948658	ATGA(1)	1
778339	778249	T	1
778341	778250	C	1
778343	778251	C	1
778345	778252	C	1
778347	778253	T	1
778349	778254	T	1
778351	778255	C	1
778353	778256	G	1
778355	778257	C	1
778357	778258	A	1
778359	778259	C	1
778361	778260	C	1
778363	778261	G	1
778365	778262	A	1
778367	778263	T	1
778369	778264	A	1
778371	778265	T	1
778373	778266	A	1
778375	778267	C	1
3942827	778268	C	1
778377	778268	C	1
778377	778269	T	1
778379	778270	A	1
778381	778271	A	1
778383	778272	A	1
778385	778273	T	1
778387	778274	T	1
778389	778275	A	1
778391	778276	T	1
778393	778277	C	1
778395	778278	A	1
778397	778279	C	1
778399	778280	A	1
778401	778281	T	1
778403	778282	A	1
778405	778283	C	1
778407	778284	T	1
778409	778285	T	1
778411	778286	C	1
778413	778287	T	1
778415	778288	T	1
778417	778289	C	1
778419	778290	C	1
778421	778291	A	1
778423	778292	A	1
778425	778293	T	1
778427	778294	T	1
778429	778295	G	1
778431	778296	G	1
778433	948707	delG	1
778435	778298	C	1
778437	778299	T	1
778439	778300	G	1
778441	778301	A	1
778443	778302	T	1
778445	778303	T	1
778447	778304	A	1
778449	778305	T	1
778451	778306	C	1
778453	778307	A	1
778455	778308	T	1
778457	778309	T	1
778459	778310	T	1
778461	778311	C	1
778463	778312	G	1
778465	778313	A	1
778467	778314	A	1
778469	778315	T	1
778471	778316	A	1
778473	778317	C	1
778475	778318	C	1
778477	778319	A	1
778479	778320	C	1
778483	778322	A	1
778481	778321	C	1
778485	778323	A	1
778487	778324	T	1
778489	778325	G	1
778491	778326	T	1
3685798	3685214	T	1
3685800	3685215	G	1
3685802	3685216	A	1
3685804	3685217	T	1
3685806	3685218	A	1
3685808	3685219	A	1
3685810	3685220	A	1
3685812	3685221	T	1
3685814	3685222	G	1
3685816	3685223	G	1
3685818	3685224	A	1
3685820	3685225	T	1
3685822	3685226	C	1
3685824	3685227	G	1
779230	779140	T	1
3685828	3685229	A	1
3685830	3685230	G	1
3685832	3685231	T	1
778666	778493	G	1
778666	778494	C	1
778666	778495	C	1
778666	778496	T	1
778666	778497	T	1
778666	778498	GAT	1
778666	778499	A	1
778666	778500	C	1
778666	778501	G	1
778666	778502	A	1
778666	778503	G	1
778666	778504	C	1
778666	778505	G	1
778666	778506	C	1
778666	778507	C	1
778666	778508	A	1
778666	778509	AGA	1
778666	2406779	G	1
778666	778511	A	1
778666	778512	C	1
778666	778513	A	1
778666	778514	T	1
778666	778515	A	1
778666	778516	G	1
778666	778517	C	1
778666	778518	G	1
778666	778519	TCT	1
778666	778520	C	1
778666	778521	G	1
778666	778522	A	1
778666	778523	C	1
778666	778524	A	1
778666	778525	C	1
778666	778526	T	1
778666	778527	C	1
778666	2406797	A	1
778666	778529	G	1
778666	778530	C	1
778666	778531	T	1
778666	778532	G	1
778666	778533	G	1
778666	778534	C	1
778666	778535	G	1
778666	778536	C	1
778666	778537	C	1
778666	778538	C	1
778666	778539	C	1
778666	778540	C	1
778666	778541	T	1
778666	778542	G	1
778666	778543	C	1
778666	778544	G	1
778666	778545	A	1
778666	778546	G	1
778666	778547	T	1
778666	778548	T	1
778666	778549	T	1
778666	778550	G	1
778666	778551	GAG	1
778666	778552	G	1
778666	778553	G	1
778666	778554	G	1
778666	2406824	C	1
778666	778556	T	1
778666	778557	T	1
778666	778558	C	1
778666	778559	A	1
778666	778560	G	1
778666	2406830	C	1
778666	778562	TGT	1
778666	778563	C	1
778666	778564	G	1
778666	778565	T	1
778666	778566	AGTGCC	1
778666	778567	G	1
778666	778568	C	1
778666	778569	C	1
778666	778570	C	1
778666	778571	T	1
778666	778572	C	1
778666	778573	G	1
778666	778574	A	1
778666	778575	G	1
778666	2406845	T	1
778666	2406846	C	1
778666	778578	T	1
778666	778579	G	1
778666	778580	A	1
778666	778581	G	1
778666	778582	C	1
778666	778583	C	1
778666	778584	C	1
778666	778585	C	1
778666	778586	C	1
778666	778587	C	1
778666	778588	C	1
778666	778589	GGGGTCGTCCAGGTACCCTTTGGT	1
778666	778590	C	1
778666	778591	A	1
778666	778592	A	1
778666	778593	G	1
778666	778594	C	1
778666	778595	GGT	1
778666	778596	C	1
778666	778597	G	1
778666	778598	T	1
778666	778599	G	1
778666	778600	T	1
778666	778601	C	1
778666	778602	C	1
778666	778603	G	1
778666	778604	C	1
778666	778605	G	1
778666	778606	GGCCTTGCGCTCGTTCAG	1
778666	2406876	G	1
778666	778608	T	1
778666	778609	C	1
778666	778610	T	1
778666	778611	A	1
778666	778612	A	1
778666	778613	A	1
778666	778614	C	1
778666	778615	G	1
778666	778616	T	1
778666	778617	G	1
778666	778618	C	1
778666	778619	T	1
778666	778620	T	1
778666	778621	A	1
778666	778622	G	1
778666	778623	C	1
778666	778624	C	1
778666	778625	G	1
778666	778626	C	1
778666	778627	T	1
778666	778628	G	1
778666	778629	C	1
778666	778630	T	1
778666	778631	G	1
778666	778632	G	1
778666	778633	C	1
778666	2406903	C	1
778666	778635	T	1
778666	778636	C	1
778666	778637	G	1
778666	778638	G	1
778666	778639	C	1
778666	778640	A	1
778666	778641	G	1
778666	778642	C	1
778666	778643	G	1
778666	778644	C	1
778666	778645	T	1
778666	778646	C	1
778666	778647	A	1
778666	778648	G	1
778666	778649	C	1
778666	778650	C	1
778666	778651	T	1
778666	2406921	C	1
778666	778653	C	1
778666	2406923	G	1
778666	778655	C	1
778666	778656	C	1
778666	778657	G	1
778666	778658	T	1
778666	778659	G	1
778666	778660	C	1
778666	778661	C	1
778666	778662	G	1
778666	778663	G	1
778666	778664	TTC	1
778666	778665	A	1
778714	778512	T	1
778714	778526	C	1
778714	778637	C	1
778752	778526	C	1
778712	778512	T	1
778712	778526	C	1
778748	778526	C	1
778748	2406830	A	1
778750	778526	C	1
778750	778592	G	1
778916	2406876	C	1
778962	778630	G	1
778742	778526	C	1
778742	778535	C	1
778950	778624	G	1
778702	2406779	T	1
779006	778651	A	1
778700	778509	delAGA	1
778956	778627	C	1
778746	778526	C	1
778746	778583	T	1
779002	778649	T	1
779036	778663	A	1
778708	778512	T	1
778826	778563	T	1
778686	778502	G	1
778836	778568	T	1
778858	2406846	A	1
778844	778572	G	1
779008	2406921	A	1
779008	778665	C	1
778738	778524	G	1
778952	778625	A	1
778766	778533	A	1
778938	778618	T	1
779038	778664	delTTC	1
779034	778662	A	1
778762	778531	G	1
778922	778610	C	1
779032	778661	A	1
779012	2406921	A	1
778994	778646	G	1
778894	778596	T	1
778794	778548	A	1
778854	2406845	A	1
778900	778599	A	1
778816	778558	A	1
778816	778600	A	1
778840	778570	T	1
778960	778629	T	1
778804	778554	A	1
779010	2406921	G	1
778698	778508	G	1
778958	778628	T	1
778740	778525	A	1
778740	778527	A	1
778740	2406797	G	1
778740	778529	A	1
778810	778556	C	1
778830	778565	C	1
778888	778593	T	1
779004	778650	G	1
779018	2406923	T	1
779030	778660	T	1
778896	778597	T	1
778674	778496	C	1
778978	778638	T	1
778680	778499	G	1
778774	778538	G	1
778936	778617	A	1
778726	778518	A	1
778852	2406845	C	1
778734	778522	T	1
778818	778559	C	1
778998	778647	T	1
778940	778619	C	1
778710	778512	T	1
778710	778583	T	1
778996	778646	G	1
778996	778648	A	1
778676	778497	C	1
778676	778648	A	1
778906	778603	A	1
778770	778536	T	1
778890	778594	T	1
778934	778616	C	1
778908	778604	T	1
778970	2406903	T	1
779022	778656	T	1
778880	778588	T	1
778688	778503	A	1
779016	2406923	A	1
778692	778505	A	1
778972	2406903	G	1
778690	778504	G	1
778944	778621	G	1
778848	778574	G	1
778672	778495	T	1
778724	778517	T	1
779026	778658	G	1
778842	778571	A	1
778768	778534	T	1
778914	2406876	T	1
778878	778587	T	1
778930	778614	A	1
778932	778615	C	1
778776	778539	T	1
778796	778549	A	1
778884	778590	T	1
778984	778552	A	1
778984	778641	A	1
778800	778552	A	1
778696	778507	T	1
778822	2406830	T	1
778790	778546	C	1
778814	778558	A	1
778902	778601	G	1
778860	778578	C	1
778868	778582	T	1
778920	778609	T	1
778754	778526	C	1
778754	778617	A	1
778974	778635	C	1
778718	778514	C	1
778704	2406779	A	1
778716	778513	G	1
778788	778545	G	1
778828	778564	A	1
778784	778543	T	1
778882	778589	delGGGGTCGTCCAGGTACCCTTTGGT	1
778948	778623	T	1
779024	778657	C	1
779014	778653	G	1
778808	2406824	T	1
778668	778493	A	1
778824	778562	delTGT	1
778926	778612	G	1
778876	778586	G	1
778684	778501	C	1
778866	778581	A	1
778694	778506	T	1
778862	778579	T	1
778904	778602	A	1
778986	778642	G	1
778802	778553	C	1
778864	778580	G	1
778778	778540	T	1
778942	778620	C	1
778954	778626	T	1
778760	778530	A	1
778820	778560	A	1
778886	778591	G	1
778682	778500	T	1
778924	778611	G	1
778968	778633	A	1
778838	778569	G	1
778992	778645	C	1
778758	2406797	C	1
778744	778526	C	1
778744	778549	A	1
778806	2406824	G	1
778990	778644	T	1
778736	778523	T	1
778856	2406846	G	1
778874	778585	T	1
778910	778605	A	1
778772	778537	T	1
778792	778547	C	1
778812	778557	C	1
778730	778520	T	1
778730	778526	C	1
778670	778494	A	1
778706	778511	T	1
779028	778659	C	1
778832	778566	delAGTGCC	1
778846	778573	A	1
778982	778640	C	1
778678	778498	delGAT	1
778980	778639	T	1
778966	778632	C	1
778720	778515	G	1
778780	778541	C	1
3564276	778643	A	1
778918	778608	C	1
778976	778636	T	1
778782	778542	A	1
778928	778613	G	1
778912	778606	delGGCCTTGCGCTCGTTCAG	1
778898	778598	C	1
778798	778551	delGAG	1
778722	778516	A	1
779000	778648	A	1
778728	778519	delTCT	1
778964	778631	A	1
778764	778532	A	1
778732	778521	C	1
778732	778550	A	1
778732	778554	A	1
778756	2406797	G	1
778870	778583	T	1
778892	778595	delGGT	1
778786	778544	A	1
778834	778567	C	1
778872	778584	A	1
778850	778575	A	1
778946	778622	C	1
779020	778655	T	1
3685834	3685232	T	1
3685836	3685233	A	1
3685838	3685234	T	1
3685840	3685235	C	1
3685842	3685236	T	1
3685844	3685237	T	1
3685846	3685238	G	1
3685848	3685239	A	1
3685850	3685240	C	1
3685852	3685241	A	1
3685854	3685242	T	1
3685856	3685243	A	1
3685858	3685244	G	1
3685860	3685245	C	1
3685862	3685245	T	1
3685864	3685246	T	1
3685866	3685247	T	1
3685868	3685248	T	1
3685870	3685249	G	1
3685872	3685250	C	1
3685874	3685251	A	1
3685876	3685252	T	1
3685878	3685253	G	1
3685880	3685254	T	1
3685882	3685255	A	1
3685884	3685256	G	1
3685886	3685257	A	1
3685888	3685258	C	1
3685890	3685259	insCT	1
3685892	3685260	T	1
3685894	3685261	C	1
3685896	3685262	T	1
3685898	3685263	A	1
3685900	3685264	C	1
3685902	3685265	G	1
3685904	3685266	A	1
3685906	3685267	T	1
3685908	3685268	A	1
3685910	3685269	A	1
779232	779141	G	1
3685914	3685271	insAA	1
3685916	3685272	A	1
3685918	3685273	T	1
3685920	3685274	A	1
3685922	3685274	T	1
3685924	3685275	C	1
779234	779142	T	1
779236	779143	T	1
3685930	3685278	delA	1
3685932	3685279	G	1
779238	779144	G	1
3685936	3685281	A	1
3685938	3685282	C	1
779240	779145	A	1
3685942	3685284	T	1
3685944	3685285	G	1
779242	779146	A	1
3685948	3685287	T	1
3685950	3685288	G	1
3685952	3685289	C	1
3685954	3685290	A	1
3685956	3685291	A	1
779244	779147	C	1
3685960	3685293	G	1
3685962	3685294	A	1
3685964	3685295	C	1
3685966	3685296	G	1
3685968	3685297	A	1
3685970	3685298	A	1
3685972	3685299	T	1
3685974	3685300	A	1
3685976	3685301	T	1
3685978	3685302	G	1
3685980	3685303	C	1
3685982	3685304	C	1
3685984	3685305	T	1
779507	779506	C	1
779509	779506	T	1
779041	779040	C	1
779043	779040	T	1
1002623	779247	C	1
1002623	779248	G	1
1002623	779249	T	1
1002623	779250	T	1
1002623	779251	A	1
1002623	779253	A	1
1002623	1002598	G	1
1002623	779254	C	1
1002623	779255	A	1
1002623	1002601	G	1
1002623	1002602	A	1
1002623	779256	T	1
1002623	6237858	C	1
1002623	6237859	A	1
1002623	779260	A	1
1002623	779261	A	1
1002623	1002606	C	1
1002623	779262	G	1
1002623	1002608	C	1
1002623	779263	T	1
1002623	6237866	G	1
1002623	779264	T	1
1002623	779265	C	1
1002623	779266	A	1
1002623	779267	G	1
1002623	779268	A	1
1002623	779269	G	1
1002623	1002616	A	1
1002623	1002617	C	1
1002623	6237875	G	1
1002623	779270	A	1
1002623	779271	A	1
1002623	779272	A	1
1002623	779273	C	1
1002623	779274	C	1
779279	779249	C	1
779281	779250	C	1
779281	779255	G	1
779283	779254	A	1
779285	779256	C	1
779287	779263	C	1
779289	779266	G	1
779291	779268	G	1
779293	779269	C	1
779295	779271	G	1
779297	779272	G	1
779299	779249	C	1
779299	779271	G	1
779301	779250	C	1
779301	779255	G	1
779301	779272	G	1
779303	779251	G	1
779303	779254	A	1
779305	779251	G	1
779305	779256	C	1
779307	779253	G	1
779313	779270	C	1
779315	779251	G	1
779315	779270	C	1
779321	779248	A	1
779323	779251	G	1
779323	779261	G	1
779325	779251	G	1
779325	779254	A	1
779325	779261	G	1
779325	779262	A	1
779327	779267	A	1
779329	779251	G	1
779329	779265	G	1
779331	779251	G	1
779331	779261	G	1
779331	779262	A	1
779333	779251	G	1
779333	779274	T	1
779335	779251	G	1
779335	779260	G	1
779337	779251	G	1
779337	779269	C	1
779339	779251	G	1
779339	779254	A	1
779339	779261	G	1
779341	779247	T	1
779341	779251	G	1
779341	779261	G	1
779341	779262	A	1
779343	779273	T	1
779347	779264	G	1
1002685	779251	G	1
1002687	1002598	A	1
1002689	779251	G	1
1002689	1002606	T	1
1002691	779256	C	1
1002691	779270	C	1
1002693	1002601	T	1
1002695	779251	G	1
1002695	1002602	G	1
1002697	779251	G	1
1002697	779254	A	1
1002697	779261	G	1
1002697	1002616	G	1
1002699	779251	G	1
1002699	779261	G	1
1002699	1002616	G	1
1002701	1002617	T	1
1002703	779251	G	1
1002703	779256	C	1
1002703	1002617	T	1
1002705	779251	G	1
1002705	779256	C	1
1002705	1002608	G	1
6237969	6237858	G	1
6237971	6237875	A	1
6237973	779251	G	1
6237973	6237866	A	1
6237975	779251	G	1
6237975	779254	A	1
6237975	779265	G	1
6237977	779251	G	1
6237977	6237859	G	1
6237977	779261	G	1
6237977	779270	C	1
\.


--
-- Data for Name: change_log; Type: TABLE DATA; Schema: cpic; Owner: -
--

COPY cpic.change_log (date, type, entityid, note, version, deployedrelease) FROM stdin;
2024-10-17	FREQUENCY	CYP2D6	corrected frequencies for PMIDs 36111505, 36294714	1	\N
2023-01-06	FREQUENCY	CYP2D6	added *140 - *163 (excluding *150, *151)	1	\N
2022-03-12	FREQUENCY	CYP2D6	added "x" infront of "≥"	1	\N
2022-03-12	FREQUENCY	CYP2D6	split *4≥2 into *4x2 and *4x≥3 to be in sync with PharmVar	1	\N
2022-03-11	FREQUENCY	CYP2D6	fixed diplotpye/phenotype calculations and made layouts consistent	1	\N
2020-10-19	FREQUENCY	CYP2D6	changed reference 26423923 to 26423926	1	\N
2020-10-14	FREQUENCY	CYP2D6	Updated phenotype frequencies to AS frequencies to be consistent with other CYP2D6 information	1	\N
2020-06-30	FREQUENCY	CYP2D6	Added alleles *115-*139 to file.	1	\N
2020-04-02	FREQUENCY	CYP2D6	Alleles *16, *66, *67, *79 and *80 removed from file (retired alleles). Added PMID 29327975 to references and added additional frequencies from PMID 31368850	1	\N
2020-03-16	FREQUENCY	CYP2D6	Corrected typo for PMID 17301689, removed duplicate rows for PMIDs 25937793 and 23619115, moved *34 frequencies from PMID 29674966 to *35, updated text in methods section, added new references	1	\N
2020-01-09	FREQUENCY	CYP2D6	Added *99 allele to allele frequency and references sheets. Removed column for undefined duplications from references sheet	1	\N
2019-12-05	FREQUENCY	CYP2D6	Altered CNV alleles to align with PharmVar and added explanation to Methods tab. Removed duplicate row for PMID 12152006 and corrected typos for PMID 16537246.	1	\N
2019-11-19	FREQUENCY	CYP2D6	Removed PMIDs 22111604, 8873218 and 18797858 because they don't contain exact frequencies. Converted references sheet from percentage to decimal format and calculated average frequencies using weighted averages. Removed columns for structural rearrangements and alleles which are not PharmVar core alleles. Moved footnotes to methods tab.	1	\N
2016-11-08	ALLELE_DEFINITION	CYP4F2	Added change log tab	1	\N
2019-10-08	ALLELE_DEFINITION	CYP4F2	Updated format, removed function column	1	\N
2022-11-11	ALLELE_DEFINITION	CYP4F2	PharmVar IDs updated	1	\N
2022-01-25	ALLELE_DEFINITION	CYP4F2	added CYP4F2*4, *5, *6 and *7	1	\N
2023-06-04	ALLELE_DEFINITION	CYP4F2	added CYP4F2*8 -*16	1	\N
2024-01-30	ALLELE_DEFINITION	CYP4F2	added *17	1	\N
2025-06-16	ALLELE_DEFINITION	CYP4F2	new haplotypes *18-*23 added	1	\N
2021-04-11	ALLELE_DEFINITION	SLCO1B1	updated alleles based on PharmVar update: Update of alleles:\n• *18, remove 578T>G (L193R) \n• *21: add L643F (1929 A>C, rs34671512)\n• Rename *1A to *1\nNew rows (new alleles):\n• Add row *37: *1B re-assigned as *37\n• Add row: *38 (old *1c), \n• Add *39, *40, *41, *42 (*39-*42 from new sequence submissions)\nNew columns (core alleles from new submission):\n• Add column: for R152L for *38 (no rsID yet, the one at the chr location show as G>C instead of G>A https://www.ncbi.nlm.nih.gov/snp/rs145144129)\n• Add column: Splice donor for core alleles from *41 from new submissions\n• Add column: Y173C for core alleles from *42 from new submissions\n• Add column: R253X for core allele from *39\nRemove rows (merges):\n• *1B: reassigned as *37\n• *17: merged *17 with *15 (-910G>A removed)\n• *18: Merge *18 with *14 (L191=, F199=, S137= removed from core allele definition)\n• *21: Merge *21 with *20 (-910G>A removed)\n• *22: Merge *22 with *19 (L191= removed)\n• *35: Merge *35 with *20 (F199= removed, no information for F199=)\nRemove columns:\n• Remove column: rs4149015 (-910G>A) from allele definition table (pass 500 upstream of exon 1)\n• Remove column: 578T>G (L193R), since *18 no longer have this\n• Remove column: L191= (rs4149057) from core allele definition, synonymous change\n• Remove column: F199= (rs2291075) from core allele definition, synonymous change\n• Remove column: S137= (rs11045818) from core allele definition, synonymous change	1	\N
2021-07-12	ALLELE_DEFINITION	SLCO1B1	Added new alleles *43-*47	1	\N
2021-12-01	ALLELE_DEFINITION	SLCO1B1	Added new alleles *48-*49	1	\N
2025-06-16	ALLELE_DEFINITION	SLCO1B1	Added new alleles *50-*54	1	\N
2024-06-27	ALLELE_FUNCTION_REFERENCE	CYP2B6	Updated summary for *39-*43 to include new evidence (PMID: 38596098). Changed clinical function of *44-*49 from unknown to uncertain based on new evidence (PMID: 38596098).	1	\N
2023-09-25	ALLELE_FUNCTION_REFERENCE	CYP2B6	Updated allele functions, references, summaries, and strength of evidence per CYP2B6/methadone team; added *39-*49	1	\N
2020-03-30	ALLELE_FUNCTION_REFERENCE	CYP2B6	*16 has been removed from PharmVar as a core allele and now is a suballele of *18, so the *16 reference not already included in the *18 evidence (PMID: 16495778) has been moved to *18	1	\N
2019-10-11	ALLELE_FUNCTION_REFERENCE	CYP2B6	Updated table notes format	1	\N
2019-10-02	ALLELE_FUNCTION_REFERENCE	CYP2B6	Updated table to new format	1	\N
2020-02-26	ALLELE_FUNCTION_REFERENCE	DPYD	Removed intronic normal function variants: c.1129-15T>C, c.763-118A>G, c.1740+39C>T, c.1740+40A>G, c.850+41T>C, c.958+134T>G, c.1340-106T>A, c.2300-39G>A, c.234-123G>C, c.850+91C>T, c.1129-28G>T, c.681-8C>T	1	\N
2020-02-24	ALLELE_FUNCTION_REFERENCE	DPYD	Removed c.680+139G>A; variant was originally assigned decreased function because of its possible connection with the Hap3B haplotype, which has decreased function, but a functional impact of c.680+139G>A by itself is uncertain. Original comment: Incomplete association with HapB3 (SNP not exclusive to HapB3 and therefore not a suitable proxy).	1	\N
2020-02-24	ALLELE_FUNCTION_REFERENCE	DPYD	Removed c.151-69G>A; variant was originally assigned decreased function because of its LD with rs115232898 (Y186C), which has decreased function, but a functional impact of c.151-69G>A by itself is uncertain. Original comment: This variant was found to be in linkage disequilibrium (D'=1) with the decreased function variant rs115232898 (Y186C); the decreased function associated with this variant is likely due to this linkage.	1	\N
2019-12-06	ALLELE_FUNCTION_REFERENCE	DPYD	Removed intronic and non-synonymous uncertain function variants: c.233+112G>T, c.234-93C>T, c.274C>G, c.484-145T>A, c.910T>C, c.1054C>G, c.1525-28A>G, c.1974+75A>G, c.2060A>C, c.2678A>G, c.2948C>T	1	\N
2019-11-19	ALLELE_FUNCTION_REFERENCE	DPYD	added AS of N/A to uncertain function alleles	1	\N
2019-10-30	ALLELE_FUNCTION_REFERENCE	DPYD	changed Strength of evidence level from "In vitro data only and/or limited clinical/ex vivo data" to "Limited" and "uncertain" to "Inadequate"	1	\N
2019-10-30	ALLELE_FUNCTION_REFERENCE	DPYD	added activity score and clinical allele function status for variants in row 28 to 99	1	\N
2019-10-30	ALLELE_FUNCTION_REFERENCE	DPYD	changed c.1129-5923C>G (HapB3) to c.1129-5923C>G, c.1236G>A (HapB3) and added note	1	\N
2019-10-30	ALLELE_FUNCTION_REFERENCE	DPYD	changed rs1801265 (*9A) to c.85T>C (*9A)	1	\N
2019-10-02	ALLELE_FUNCTION_REFERENCE	DPYD	Update format	1	\N
2023-12-05	ALLELE_FUNCTION_REFERENCE	RYR1	File was updated to include the RYR1 variants from supplemental table S2 of the ClinGen RYR1 VCEP publication 35849058 (see Notes tab); variant classification updated based on VCEP disusssion - see Notes tab	1	\N
2019-10-01	FREQUENCY	CYP2D6	Phenotype frequecies calculated based on phenotype groupings proposed in PMID 31647186	1	\N
2019-02-08	FREQUENCY	CYP2D6	removed He et al 2016 (PMID 27228982); rs28371703 does not tag *48; rs769157652 not exclusive to *27; not clear how alleles were called as SNP frequencies (Tab1) are not consistent with allele frequencies in Tab2	1	\N
2019-01-08	FREQUENCY	CYP2D6	reclassified ethnicity groupings according to new standardized biogeographic grouping (Huddart et al PMID 30506572)	1	\N
2018-12-15	FREQUENCY	CYP2D6	calcutaed frequencies seperately for American and Latino	1	\N
2018-12-14	FREQUENCY	CYP2D6	removed all studies with mixed and/or unknown popualtion information from groupings; these are now listed in the bottom section	1	\N
2018-12-12	FREQUENCY	CYP2D6	added a total of 28 papers (EN 199-227) resulting in the addition of 50 discrete entries (highlighted in red)	1	\N
2018-12-12	FREQUENCY	CYP2D6	added coumn for *114; added note to *14 reading 'formerly *14B'	1	\N
2018-12-06	FREQUENCY	CYP2D6	added column for *3xN	1	\N
2018-12-06	FREQUENCY	CYP2D6	changed *36+*10x2 to *36+*10xN and *36x2+*10 to *36xN+*10; removed column for *36x3+*10	1	\N
2016-07-15	FREQUENCY	CYP2D6	all sections were sorted by columns E-B-A (ethnicity-year-author)	1	\N
2016-07-14	FREQUENCY	CYP2D6	added 30 papers	1	\N
2016-05-31	FREQUENCY	CYP2D6	added columns for *107, *108 and *109 and added ethnicity of subject in which respective allele was detected	1	\N
2016-05-31	FREQUENCY	CYP2D6	added one column for *87-*98 and annotated as 'detected'	1	\N
2016-05-31	FREQUENCY	CYP2D6	added column for *1+*83 and approximate frequency	1	\N
2015-01-02	FREQUENCY	CYP2D6	added 1 paper	1	\N
2019-01-18	ALLELE_DEFINITION	DPYD	Added guideline variants	1	\N
2019-10-02	ALLELE_DEFINITION	DPYD	Update format	1	\N
2019-10-25	ALLELE_DEFINITION	DPYD	changed c.1129-5923C>G (HapB3) to c.1129-5923C>G, c.1236G>A (HapB3) and deleted c.483+18G>A column	1	\N
2019-10-25	ALLELE_DEFINITION	DPYD	changed rs1801265 (*9A) to c.85T>C (*9A)	1	\N
2019-10-25	ALLELE_DEFINITION	DPYD	changed c.2657G>A (*9B) to c.85T>C, c.2657G>A (*9B)	1	\N
2019-12-02	ALLELE_DEFINITION	DPYD	changed nucleotides in the grid to reflect nucleotide change on the positive strand	1	\N
2019-12-02	ALLELE_DEFINITION	DPYD	sorted variants to follow sequence	1	\N
2019-12-06	ALLELE_DEFINITION	DPYD	Removed intronic and non-synonymous uncertain function variants: c.233+112G>T, c.234-93C>T, c.274C>G, c.484-145T>A, c.910T>C, c.1054C>G, c.1525-28A>G, c.1974+75A>G, c.2060A>C, c.2678A>G, c.2948C>T	1	\N
2020-02-24	ALLELE_DEFINITION	DPYD	Removed c.151-69G>A; variant was originally assigned decreased function because of its LD with rs115232898 (Y186C), which has decreased function, but a functional impact of c.151-69G>A by itself is uncertain. Original comment: This variant was found to be in linkage disequilibrium (D'=1) with the decreased function variant rs115232898 (Y186C); the decreased function associated with this variant is likely due to this linkage.	1	\N
2020-02-24	ALLELE_DEFINITION	DPYD	Removed c.680+139G>A; variant was originally assigned decreased function because of its possible connection with the Hap3B haplotype, which has decreased function, but a functional impact of c.680+139G>A by itself is uncertain. Original comment: Incomplete association with HapB3 (SNP not exclusive to HapB3 and therefore not a suitable proxy).	1	\N
2020-02-26	ALLELE_DEFINITION	DPYD	Removed intronic normal function variants: c.1129-15T>C, c.763-118A>G, c.1740+39C>T, c.1740+40A>G, c.850+41T>C, c.958+134T>G, c.1340-106T>A, c.2300-39G>A, c.234-123G>C, c.850+91C>T, c.1129-28G>T, c.681-8C>T	1	\N
2020-08-17	ALLELE_DEFINITION	DPYD	added del into g.97740411_97740414ATGA cell F4	1	\N
2021-09-02	ALLELE_DEFINITION	DPYD	changed representation for rs72549309 from c.295_298delTCAT, p.F100Sfs, g.97740411_97740414delATGA, g.185642_185645delTCAT, reference cell: ATGA, allele cell: delATGA to c.299_302del, g.97740411ATGA[1], g.185642TCAT[1], reference cell: ATGA(2), allele cell: ATGA(1) to match the PharmVar API content	1	\N
2021-09-02	ALLELE_DEFINITION	DPYD	removed base from row 2, 4, 5 for c.1898del	1	\N
2021-10-13	ALLELE_DEFINITION	DPYD	added note about variant source	1	\N
2023-03-02	ALLELE_DEFINITION	DPYD	PharmVar ID changed for rs72549309	1	\N
2024-01-11	ALLELE_DEFINITION	DPYD	Added c.1129-5923C>G as a single allele in addition to the HapB3 allele; further information in Notes	1	\N
2024-01-30	ALLELE_DEFINITION	DPYD	added PharmVar ID for c.1129-5923C>G	1	\N
2024-07-09	ALLELE_DEFINITION	DPYD	added protein header at AA3 - splicing defect	1	\N
2018-04-25	ALLELE_DEFINITION	TPMT	released	1	\N
2019-10-08	ALLELE_DEFINITION	TPMT	Updated format, removed function column	1	\N
2020-06-16	ALLELE_DEFINITION	TPMT	Updated the alleles on the NC and NG sequence for *36	1	\N
2020-06-23	ALLELE_DEFINITION	TPMT	Added *42, *43 and *44	1	\N
2021-09-29	ALLELE_DEFINITION	TPMT	updated link to Nomenclature website and added note	1	\N
2019-05-07	ALLELE_FUNCTION_REFERENCE	CYP2C19	combined *4A and *4B into *4 (PharmVar core allele release)	1	\N
2019-05-07	ALLELE_FUNCTION_REFERENCE	CYP2C19	removed *27, added *27 references into the *1 PMID cell (PharmVar re-assigned *27 as *1 suballele)	1	\N
2019-08-30	ALLELE_FUNCTION_REFERENCE	CYP2C19	added 24945780 to PMID cell for *10	1	\N
2019-08-30	ALLELE_FUNCTION_REFERENCE	CYP2C19	added 27578295 to PMID cell for *23	1	\N
2019-08-30	ALLELE_FUNCTION_REFERENCE	CYP2C19	added 30464555 to PMID cell for *23, *29, 30, *31, *32, *33	1	\N
2019-08-30	ALLELE_FUNCTION_REFERENCE	CYP2C19	added *36 and *37 alleles	1	\N
2019-12-04	ALLELE_FUNCTION_REFERENCE	CYP2C19	moved reviewer comments into the comment section	1	\N
2019-12-04	ALLELE_FUNCTION_REFERENCE	CYP2C19	changed Required to Optional for PMID	1	\N
2019-12-04	ALLELE_FUNCTION_REFERENCE	CYP2C19	changed Required to Optional for Comments	1	\N
2020-03-25	ALLELE_FUNCTION_REFERENCE	CYP2C19	changed red text color to black for *36 and *37 rows	1	\N
2020-06-29	ALLELE_FUNCTION_REFERENCE	CYP2C19	added *38	1	\N
2020-07-17	ALLELE_FUNCTION_REFERENCE	CYP2C19	fixed typo in change dates on this tab	1	\N
2020-08-07	ALLELE_FUNCTION_REFERENCE	CYP2C19	added missing PMID for *1 in PMIDs column	1	\N
2021-04-22	ALLELE_FUNCTION_REFERENCE	CYP2C19	*1: Added PMIDs: 32602114, 22027650 to reflect well established normal function (PharmGKB and PharmVar CYP2C19 review articles) |Removed PMIDs: 12464799, 17455109, 18312490, 21325430, 25001882, 20712527, 26244421, 7484048 becuase well established alleles do not require primary literature review	1	\N
2021-04-22	ALLELE_FUNCTION_REFERENCE	CYP2C19	*2: Added PMID 22027651 to reflect well established no function (PharmGKB CYP2C19 review article) | Removed PMIDS 9732415, 19661214, 9103550 becuase well established alleles do not require primary literature review	1	\N
2014-12-08	FREQUENCY	CYP2D6	studies used for *1 calculations are highlighted in blue	1	\N
2014-11-14	FREQUENCY	CYP2D6	added 1 paper	1	\N
2014-11-03	FREQUENCY	CYP2D6	included column to calculate sum of variants for studies and the sume of the averages of variants	1	\N
2014-11-03	FREQUENCY	CYP2D6	Flagged studies (blue) to be included into *1 calculations	1	\N
2014-10-30	FREQUENCY	CYP2D6	Moved Ashkenazi Jews from Europe to other (consistent with 2C19 frequency table)	1	\N
2014-10-30	FREQUENCY	CYP2D6	papers added for R2 changed from red to black; new papers added for R3 changed to red	1	\N
2014-10-30	FREQUENCY	CYP2D6	added column for *75	1	\N
2014-10-30	FREQUENCY	CYP2D6	sorted by columns E-B-A (ethnicity-year-author)	1	\N
2014-10-28	FREQUENCY	CYP2D6	added 9 papers	1	\N
2013-09-09	FREQUENCY	CYP2D6	Added data for *1, *2 and *35 received from Ana Santander for PMID 23922954	1	\N
2013-08-30	FREQUENCY	CYP2D6	have not heard back from Zafra-Ceres to confirm allele freq	1	\N
2013-08-29	FREQUENCY	CYP2D6	correponded with Antunes; mistake in paper re some freq;	1	\N
2013-08-28	FREQUENCY	CYP2D6	excluded Zihlif et al. *10 incorrectly called; corresponded with author revealing this mishap	1	\N
2013-08-17	FREQUENCY	CYP2D6	corrected *76+*2 to *76+*1	1	\N
2013-08-16	FREQUENCY	CYP2D6	added 5 papers (6 line entires) for East Asia	1	\N
2013-08-16	FREQUENCY	CYP2D6	added 5 papers (5 line entries( for Europe	1	\N
2013-08-16	FREQUENCY	CYP2D6	added 4 papers (6 line entires) for Americas	1	\N
2018-09-26	ALLELE_DEFINITION	G6PD	Added change log tab	1	\N
2019-10-08	ALLELE_DEFINITION	G6PD	Updated format, removed function column	1	\N
2021-01-12	ALLELE_DEFINITION	G6PD	Updated the names to remove "G6PD" for Nice, A- 680T_376G and A- 968C_376G for consistency	1	\N
2021-02-25	ALLELE_DEFINITION	G6PD	Removed the Hektoen variant which has no mapping information. Approved by G6PD guideline authors.	1	\N
2023-09-22	ALLELE_DEFINITION	G6PD	Change "Telti/Kobe" to "Telti, Kobe" to avoid collision with diplotype syntax	1	\N
2017-11-03	ALLELE_DEFINITION	UGT1A1	Added change log tab	1	\N
2019-10-08	ALLELE_DEFINITION	UGT1A1	Updated format, removed function column	1	\N
2021-04-01	ALLELE_DEFINITION	UGT1A1	deleted column for -3275T>G, *60 was removed as row but position was still included	1	\N
2021-09-24	ALLELE_DEFINITION	UGT1A1	changed representation for *36, *27, *28 from g.233760233 to g.233760235TA[6]; g.233760235TA[7]; g.233760235TA[8]; g.233760235TA[9] and from g.175490 to g.175492TA[6]; g.175492TA[7]; g.175492TA[8]; g.175492TA[9]	1	\N
2023-04-28	ALLELE_DEFINITION	UGT1A1	Updated the notes tab to (1) remove a dead link, (2) remove reference to *60 which is not included in this file and (3) explain the count of TA repeats in several alleles	1	\N
2021-04-22	ALLELE_FUNCTION_REFERENCE	CYP2C19	*3: Added PMID 22027651 to reflect well established no function (PharmGKB CYP2C19 review article)	1	\N
2021-04-22	ALLELE_FUNCTION_REFERENCE	CYP2C19	*25: Added PMID 19636337. In sillico data. Article cited on PharmVar and likely evaluated by authors	1	\N
2021-04-22	ALLELE_FUNCTION_REFERENCE	CYP2C19	*28: Added PMID 20712527. In sillico data. Article cited on PharmVar and likely evaluated by authors	1	\N
2021-04-22	ALLELE_FUNCTION_REFERENCE	CYP2C19	*38: Added PMID 32602114. PharmVar article which details the change in star allele designation	1	\N
2021-05-07	ALLELE_FUNCTION_REFERENCE	CYP2C19	added 29325448, 33237321 to PMID for *1	1	\N
2021-05-07	ALLELE_FUNCTION_REFERENCE	CYP2C19	added 21692664 to PMID for *5, *8, *9, *10, *11, *19	1	\N
2021-05-07	ALLELE_FUNCTION_REFERENCE	CYP2C19	added 17625515, 32857933, 29325448, 29136336, 31649299, 20083681 to PMID for *17 and changed level of evidence from strong to definitive	1	\N
2021-05-07	ALLELE_FUNCTION_REFERENCE	CYP2C19	added 19164093 to PMID for *22	1	\N
2021-05-07	ALLELE_FUNCTION_REFERENCE	CYP2C19	added 31713493 to PMID for *22, *23, *24	1	\N
2021-05-07	ALLELE_FUNCTION_REFERENCE	CYP2C19	added 29098786 *29, *30, *31, *32, *33	1	\N
2021-09-17	ALLELE_FUNCTION_REFERENCE	CYP2C19	*39 added	1	\N
2019-10-10	ALLELE_FUNCTION_REFERENCE	G6PD	Table created	1	\N
2019-10-11	ALLELE_FUNCTION_REFERENCE	G6PD	Updated table notes	1	\N
2020-07-07	ALLELE_FUNCTION_REFERENCE	G6PD	Updated allele function with CPIC terms	1	\N
2021-01-12	ALLELE_FUNCTION_REFERENCE	G6PD	Updated the names to remove "G6PD" for Nice, A- 680T_376G and A- 968C_376G for consistency	1	\N
2021-02-25	ALLELE_FUNCTION_REFERENCE	G6PD	Removed the Hektoen variant, which has no mapping information	1	\N
2021-11-16	ALLELE_FUNCTION_REFERENCE	G6PD	Added finding statements and strength of evidence for all variants	1	\N
2023-02-02	ALLELE_FUNCTION_REFERENCE	G6PD	Update function assignment for Tokyo and Farroupilha to standardize with CPIC G6PD function terms based on work from Geck, et al. 2023	1	\N
2023-09-22	ALLELE_FUNCTION_REFERENCE	G6PD	Change "Telti/Kobe" to "Telti, Kobe" to avoid collision with diplotype syntax	1	\N
2021-10-22	ALLELE_FUNCTION_REFERENCE	RYR1	Based on the ClinGen's variant curation expert panel (VCEP) recommendations for RYR1 pathogenicity classification in malignant hyperthermia susceptibility (PMID 33767344) two variants have been changed from "malignant hyperthermia associated" to "uncertain function"	1	\N
2020-10-09	ALLELE_FUNCTION_REFERENCE	RYR1	changed c.7039_7041delGAG or c.7042_7044delGAG name to c.7042_7044delGAG to reflect naming as on the EMHG list and used mapping data that correspond with the rsID in dbSNP	1	\N
2020-07-07	ALLELE_FUNCTION_REFERENCE	RYR1	Changed column B header to "Activity Value"	1	\N
2020-06-11	ALLELE_FUNCTION_REFERENCE	RYR1	Added reference row and assigned normal function	1	\N
2019-10-11	ALLELE_FUNCTION_REFERENCE	RYR1	Updated table notes; updated allele name to "c.7039_7041delGAG or c.7042_7044delGAG"	1	\N
2019-10-09	ALLELE_FUNCTION_REFERENCE	RYR1	Updated to new format.	1	\N
2020-07-15	GENE_CDS	SLCO1B1	changed EHR Priority Result Notation from Normal/Routine/Low Risk to none for Possible Increased Function based on Consultation text	1	\N
2020-07-15	GENE_CDS	SLCO1B1	added EHR Priority Result Notation none and consultation text for Indeterminate	1	\N
2021-06-23	GENE_CDS	SLCO1B1	Deleted recommendation specific to simvastatin for decreased and poor function and added information for all statins; removed "possible" phenotypes	1	\N
2013-08-16	FREQUENCY	CYP2D6	added 2 papers (2 line entries) for Africa	1	\N
2013-08-16	FREQUENCY	CYP2D6	added 1 paper with 'unspecified' ethnicity and approximate frequency	1	\N
2013-08-16	FREQUENCY	CYP2D6	added 1 paper with approxomate frequency	1	\N
2013-08-16	FREQUENCY	CYP2D6	sorted ethnicities by 1) major ethnicity, 2) population, 3) year and 4) author	1	\N
2013-08-16	FREQUENCY	CYP2D6	added number of subjects for Yin et al. and updated year of publication	1	\N
2013-08-16	FREQUENCY	CYP2D6	added number of subjects for Ebisawa et al.	1	\N
2013-08-16	FREQUENCY	CYP2D6	corrected entries for *13 'revised' for all ethnicities (0 was incorrect for most)	1	\N
2013-08-16	FREQUENCY	CYP2D6	added columns for *61, *62, *84, *85, *86, *100, *101, *36x3+*10 and *1x2+*83	1	\N
2013-08-16	FREQUENCY	CYP2D6	revised/updated ethnicities and populations for Americas	1	\N
2013-08-13	FREQUENCY	CYP2D6	corrected spelling of von Ahsen	1	\N
2024-03-20	RECOMMENDATION	RxNorm:1256	Updated for the following phenotypes: TPMT Intermediate Metabolizer/NUDT15 Intermediate Metabolizer, TPMT Intermediate Metabolizer/Possible NUDT15 Intermediate Metabolizer, Possible TPMT Intermediate Metabolizer/NUDT15 Intermediate Metabolizer, Possible TPMT Intermediate Metabolizer/Possible NUDT15 Intermediate Metabolizer	1	\N
2020-07-14	RECOMMENDATION	RxNorm:1256	log created	1	\N
2024-07-08	RECOMMENDATION	RxNorm:6918	File created	1	\N
2023-05-10	TEST_ALERT	RxNorm:2597	changed AS ≥4.5 to ≥3.75 and 3.5 to 2.75 duu to changes in the CYP2D6 allele function assignment	1	\N
2020-07-20	TEST_ALERT	RxNorm:2597	added rows for CYP2D6 AS: ≥6, ≥5, ≥4.5, ≥4, ≥3.5, ≥3.25, ≥3, 4, 3.5, 3, 2.5	1	\N
2022-03-17	TEST_ALERT	RxNorm:301542	remvoe ABCG2 indeterminate rows	1	\N
2021-08-02	TEST_ALERT	RxNorm:301542	created	1	\N
2021-09-08	TEST_ALERT	RxNorm:4815	created	1	\N
2018-09-17	ALLELE_DEFINITION	CACNA1S	Added change log tab	1	\N
2019-10-08	ALLELE_DEFINITION	CACNA1S	Updated format, removed function column	1	\N
2019-08-23	ALLELE_DEFINITION	IFNL3	Added change log tab	1	\N
2019-10-08	ALLELE_DEFINITION	IFNL3	Updated format, removed function column	1	\N
2019-08-23	ALLELE_DEFINITION	VKORC1	Added change log tab	1	\N
2019-10-08	ALLELE_DEFINITION	VKORC1	Updated format, removed function column	1	\N
2019-09-05	ALLELE_FUNCTION_REFERENCE	CYP2C9	Updated table to new format, added new alleles from PharmVar and new references. Made changes to functional assignments.	1	\N
2019-10-01	ALLELE_FUNCTION_REFERENCE	CYP2C9	Added references for *9 and *10	1	\N
2019-10-11	ALLELE_FUNCTION_REFERENCE	CYP2C9	Updated table notes format	1	\N
2019-12-05	ALLELE_FUNCTION_REFERENCE	CYP2C9	Added "N/A" to cells in the Activity Score column for unknown or uncertain function alleles.	1	\N
2020-04-28	ALLELE_FUNCTION_REFERENCE	CYP2C9	Fixed separator syntax in finding field	1	\N
2020-04-29	ALLELE_FUNCTION_REFERENCE	CYP2C9	Fixed separator in PMIDs field for *27	1	\N
2020-07-07	ALLELE_FUNCTION_REFERENCE	CYP2C9	Changed column B header to "Activity Value"	1	\N
2020-08-07	ALLELE_FUNCTION_REFERENCE	CYP2C9	Fixed typo in Findings column for *1	1	\N
2021-04-15	ALLELE_FUNCTION_REFERENCE	CYP2C9	Edited evidence summary column to comply with revised allele function SOP	1	\N
2021-04-26	ALLELE_FUNCTION_REFERENCE	CYP2C9	Added PMID 15637526 to PMID column for *2	1	\N
2022-01-24	ALLELE_FUNCTION_REFERENCE	CYP2C9	Added *62 to *75; other alleles (*1-*61 were not updated at this time)	1	\N
2020-08-05	ALLELE_FUNCTION_REFERENCE	MT-RNR1	File created	1	\N
2023-12-20	ALLELE_FUNCTION_REFERENCE	MT-RNR1	Added "m." prefix to allele names	1	\N
2019-10-10	ALLELE_FUNCTION_REFERENCE	SLCO1B1	Update table to new format, the functions for "*4, *7, *8, *11, *12, *13, *16, *18, *19, *20, *21, *22, *24, *25, *26, *27, *28, *29, *30, *32, *33, *34, *36" were left blank. They were grouped under "Unknown/unclear/contradictory evidence" in table S2	1	\N
2021-04-29	ALLELE_FUNCTION_REFERENCE	SLCO1B1	Based on PharVar assessments of SLCO1B1 allele defintion, *1A renamed *1, *1B renamed as *37, *1C reassigned as *38, added new alleles *39, *40, *41, *42, merged *17 with *15, merged *18 with *14, *21 with *20, *22 with *1, and *35 with *20.	1	\N
2021-07-08	ALLELE_FUNCTION_REFERENCE	SLCO1B1	Authors updated allele function, PMIDs, and Findings and added additional alleles based on PharmVar	1	\N
2021-11-16	ALLELE_FUNCTION_REFERENCE	SLCO1B1	Added *48 and *49	1	\N
2022-02-09	FREQUENCY	ABCG2	frequency file created.	1	\N
2022-03-11	FREQUENCY	ABCG2	fixed diplotpye/phenotype calculations and made layouts consistent	1	\N
2018-07-03	FREQUENCY	CYP2B6	Removed columns for snps found in multiple * alleles, and the corresponding references, added * alleles for which we have no information	1	\N
2018-12-19	FREQUENCY	CYP2B6	Added PMID: 21886015 for columbian population	1	\N
2019-10-22	FREQUENCY	CYP2B6	Converted table to use PharmGKB biogeographical groups and updated to new standardized format. Average allele frequencies now calculated using weighted averages	1	\N
2020-02-28	FREQUENCY	CYP2B6	Added diplotype and phenotype frequencies. Up dated information on biogeographical groups in methods tab.	1	\N
2020-03-30	FREQUENCY	CYP2B6	*16 has been removed from PharmVar as a core allele and now is a suballele of *18, so *16 has been removed leading to a slight frequency increase in the *1 allele in the Sub-Saharan African group	1	\N
2022-03-11	FREQUENCY	CYP2B6	fixed diplotpye/phenotype calculations and made layouts consistent	1	\N
2020-04-22	FREQUENCY	CYP2C19	Added PMID: 27849442 PMID: 28873029 PMID: 19069365 PMID: 30143732; transferred changes to Allele frequency tab	1	\N
2020-02-28	FREQUENCY	CYP2C19	Added diplotype and phenotype frequencies. Updated information on Methods tab	1	\N
2019-10-24	FREQUENCY	CYP2C19	Changed average allele frequency calculations to weighted averages. Removed *4A, *4B, *20, *21 and *27 from References sheet as these are not PharmVar core alleles.	1	\N
2019-10-10	FREQUENCY	CYP2C19	deleted EN column from References tab	1	\N
2019-09-13	FREQUENCY	CYP2C19	added *36 and *37 to allele frequency by race	1	\N
2019-07-17	FREQUENCY	CYP2C19	Removed studies PMID 23130019, 23249123 and 20712527 because these studies appeared to contain individuals of mixed ethnicities	1	\N
2019-07-17	FREQUENCY	CYP2C19	Changed ethnicities to updated PharmGKB Biographical groups, and moved studies into new ethinicity categories as appropriate	1	\N
2019-07-17	FREQUENCY	CYP2C19	Removed studies containing mixed populations (rows 485-495 in original Excel file) since they do not fall under any of the ethnicity categories	1	\N
2017-11-03	FREQUENCY	CYP2C19	updated diplotype frequencies	1	\N
2017-02-13	FREQUENCY	CYP2C19	updated the footnotes on the "Allele frequency by race" tab	1	\N
2016-05-30	FREQUENCY	CYP2C19	added 3 papers	1	\N
2016-05-27	FREQUENCY	CYP2C19	added 25 papers	1	\N
2016-05-27	FREQUENCY	CYP2C19	4 studies on Chinese were in Central/South Asian category - moved to East Asia	1	\N
2016-05-11	FREQUENCY	CYP2C19	added 16 papers	1	\N
2021-09-08	TEST_ALERT	RxNorm:10831	created	1	\N
2017-02-13	FREQUENCY	CYP3A5	updated footnotes	1	\N
2019-10-24	FREQUENCY	CYP3A5	Converted to PharmGKB biogeographical groups. Updated document to new standardized format and to use weighted average allele frequencies	1	\N
2020-02-27	FREQUENCY	CYP3A5	Updated information in methods tab	1	\N
2022-03-11	FREQUENCY	CYP3A5	fixed diplotpye/phenotype calculations and made layouts consistent	1	\N
2022-02-22	RECOMMENDATION	RxNorm:2002	Fix the format of the "No Result" Allele Status values	1	\N
2020-07-14	RECOMMENDATION	RxNorm:7531	added AS AS 2.5, 3, 3.5, 4, ≥3, ≥3.25, ≥3.5, ≥4, ≥4.5, ≥5, ≥6 rows	1	\N
2023-05-10	RECOMMENDATION	RxNorm:7531	changed AS ≥4.5 to ≥3.75 and 3.5 to 2.75 duu to changes in the CYP2D6 allele function assignment	1	\N
2021-08-03	TEST_ALERT	RxNorm:32968	created	1	\N
2020-07-21	TEST_ALERT	RxNorm:36453	split RYR1 or CACNA1S phenotyp and RYR1 or CACNA1S Activity score in one column per gene to match other two gene tables	1	\N
2023-05-10	TEST_ALERT	RxNorm:5489	added rows for CYP2D6 AS: ≥6, ≥5, ≥3.75, ≥4, ≥3.5, ≥3.25, ≥3, 4, 2.75, 3, 2.5	1	\N
2021-09-08	TEST_ALERT	RxNorm:10184	created	1	\N
2019-05-10	ALLELE_DEFINITION	CFTR	removed G85E, N1303K, W1282X, I507del, R347P, R560T, R334W ivacaftor label states"... mutations in the CFTR gene do not meet the threshold of change in CFTR mediated chloride transport of at least 10% of normal over baseline" However, variants are part of the variants recommended by the American College of Medical Genetics (ACMG) Cystic Fibrosis Carrier Screening Working Group that should be tested to determine carrier status as a part of population screening programs PMID 15371902.	1	\N
2019-05-10	ALLELE_DEFINITION	CFTR	removed G542, R553X, 1717-1G>A, 621+1G>T, R1162X, 3120+1G>A, 1898+1G>A, 3659delC, 2184delA. Variants have no recommendation but are part of the variants recommended by the American College of Medical Genetics (ACMG) Cystic Fibrosis Carrier Screening Working Group that should be tested to determine carrier status as a part of population screening programs PMID 15371902.	1	\N
2019-05-10	ALLELE_DEFINITION	CFTR	added 3272-26A>G, E831X as per table 3 ivacaftor label accessed May 2019	1	\N
2019-10-09	ALLELE_DEFINITION	CFTR	Updated table format and added additional alleles from label	1	\N
2020-03-04	ALLELE_DEFINITION	CFTR	removed G85E and added back g.117559591_117559593delTCT	1	\N
2020-03-09	ALLELE_DEFINITION	CFTR	added column for G1244E back	1	\N
2016-09-08	FREQUENCY	CYP4F2	created version 1	1	\N
2017-02-13	FREQUENCY	CYP4F2	updated footnotes	1	\N
2017-02-22	FREQUENCY	CYP4F2	updated allele with * nomenclature	1	\N
2019-10-18	FREQUENCY	CYP4F2	updated the allele name to match with the allele definition table	1	\N
2019-10-25	FREQUENCY	CYP4F2	Allele frequencies now in decimal format. Converted to biogeographical groups and weighted average allele frequencies, added Methods sheet and updated document to new standardized format	1	\N
2022-03-23	FREQUENCY	CYP4F2	Added *2, *3 frequency using gnomad data	1	\N
2020-07-14	RECOMMENDATION	RxNorm:2597	added AS AS 2.5, 3, 3.5, 4, ≥3, ≥3.25, ≥3.5, ≥4, ≥4.5, ≥5, ≥6 rows	1	\N
2023-05-10	RECOMMENDATION	RxNorm:2597	changed AS ≥4.5 to ≥3.75 and 3.5 to 2.75 duu to changes in the CYP2D6 allele function assignment	1	\N
2020-07-14	RECOMMENDATION	RxNorm:26225	added AS AS 2.5, 3, 3.5, 4, ≥3, ≥3.25, ≥3.5, ≥4, ≥4.5, ≥5, ≥6 rows	1	\N
2023-05-10	RECOMMENDATION	RxNorm:26225	changed AS ≥4.5 to ≥3.75 and 3.5 to 2.75 duu to changes in the CYP2D6 allele function assignment	1	\N
2020-07-21	TEST_ALERT	RxNorm:27340	split RYR1 or CACNA1S phenotyp and RYR1 or CACNA1S Activity score in one column per gene to match other two gene tables	1	\N
2023-07-17	TEST_ALERT	RxNorm:36567	fixed typo: "<<=20 mg/kg" to ""<20 mg/kg"	1	\N
2021-07-30	TEST_ALERT	RxNorm:36567	Deleted possible phenotypes and increased function; updated CDS alerts text to reflect recommendations in 2021 guideline	1	\N
2020-07-15	TEST_ALERT	RxNorm:36567	added row for possible increased function	1	\N
2021-09-08	TEST_ALERT	RxNorm:5521	created	1	\N
2021-09-08	TEST_ALERT	RxNorm:9524	created	1	\N
2020-03-09	ALLELE_DEFINITION	CFTR	removed "T" in column R117H/ Class: IV and row E831X	1	\N
2020-03-09	ALLELE_DEFINITION	CFTR	exchanged g.4609A>G with g.150772A>G for 3272-26A->G in NG sequence field	1	\N
2020-03-09	ALLELE_DEFINITION	CFTR	changed C>T to C>A for g.70172C>A in D110E	1	\N
2020-03-09	ALLELE_DEFINITION	CFTR	removed 711+1G->T/ Class: I and added 711+3A->G	1	\N
2020-05-22	ALLELE_DEFINITION	CFTR	removed F508del variant	1	\N
2020-05-26	ALLELE_DEFINITION	CFTR	replaced reference with "ivacaftor non-responsive CFTR sequence"	1	\N
2021-02-11	ALLELE_DEFINITION	MT-RNR1	Created file	1	\N
2021-06-09	ALLELE_DEFINITION	MT-RNR1	Added variants with no rsID	1	\N
2021-08-16	ALLELE_DEFINITION	MT-RNR1	Combined columns for 807 variants	1	\N
2023-12-20	ALLELE_DEFINITION	MT-RNR1	Added "m." prefix to allele names	1	\N
2021-07-08	ALLELE_FUNCTION_REFERENCE	ABCG2	Created	1	\N
2024-05-26	ALLELE_FUNCTION_REFERENCE	CYP2D6	added *27x2 and *28x2	1	\N
2023-08-31	ALLELE_FUNCTION_REFERENCE	CYP2D6	*57 removed, *57 was re-assigned to CYP2D6*36.005 by PharmVar	1	\N
2023-03-20	ALLELE_FUNCTION_REFERENCE	CYP2D6	Changes from 11/08/2022 were released in the CPIC db in March 2023	1	\N
2022-11-08	ALLELE_FUNCTION_REFERENCE	CYP2D6	Added strength of evidence and added and updated summaries to all alleles	1	\N
2022-11-08	ALLELE_FUNCTION_REFERENCE	CYP2D6	Added *140 to *163 (except *150, *151- were pending at the time)	1	\N
2022-11-08	ALLELE_FUNCTION_REFERENCE	CYP2D6	Changed function assignment for *9, *32, *41, *52, *91, *109, *119, *132,	1	\N
2022-03-08	ALLELE_FUNCTION_REFERENCE	CYP2D6	Update structural variants to agree with PharmVar nomenclature	1	\N
2020-08-07	ALLELE_FUNCTION_REFERENCE	CYP2D6	Fixed PMID field for *2 and *10 (added missing PMIDs)	1	\N
2020-04-10	ALLELE_FUNCTION_REFERENCE	CYP2D6	*84 changed to uncertain function after discussion with 2D6 guideline authors	1	\N
2020-03-10	ALLELE_FUNCTION_REFERENCE	CYP2D6	Function updated for *72, *81, *120, *124, and *129	1	\N
2019-12-05	ALLELE_FUNCTION_REFERENCE	CYP2D6	Altered CNV alleles to align with PharmVar; added PMIDs from PharmVar structural document; added "N/A" as activity score for unknown or uncertain function alleles	1	\N
2019-09-11	ALLELE_FUNCTION_REFERENCE	CYP2D6	Updated sheet to new format, added alleles with unknown function and new alleles from PharmVar (*115 to *139), added activity scores and new references	1	\N
2019-01-23	ALLELE_FUNCTION_REFERENCE	NUDT15	Added change log tab	1	\N
2019-10-09	ALLELE_FUNCTION_REFERENCE	NUDT15	Updated format	1	\N
2020-07-07	ALLELE_FUNCTION_REFERENCE	NUDT15	Changed column B header to "Activity Value"	1	\N
2019-10-09	ALLELE_FUNCTION_REFERENCE	TPMT	Updated format	1	\N
2020-07-07	ALLELE_FUNCTION_REFERENCE	TPMT	Changed column B header to "Activity Value"	1	\N
2019-10-22	FREQUENCY	CACNA1S	Converted to PharmGKB biogeographical groups, added References, Methods and Change Log sheets. Average allele frequencies now calculated using weighted averages.	1	\N
2019-12-09	FREQUENCY	CACNA1S	Removed rsID and protein change columns from Allele frequency sheet. Changed rsIDs on Reference sheet to equivalent nucleotide changes	1	\N
2020-02-27	FREQUENCY	CACNA1S	Updated information about biogeogrpahical groups on methods tab	1	\N
2022-03-11	FREQUENCY	CYP2C19	fixed diplotpye/phenotype calculations and made layouts consistent	1	\N
2021-09-17	FREQUENCY	CYP2C19	added *39 in the allele frequency and references tab	1	\N
2020-12-30	FREQUENCY	CYP2C19	corrected frequency for *35 for PMID: 26021325 for the Sub-Saharan African Luhya in Webuye (LWK) and Esan (ESN) entry, which changes the allele frequency for *35 from 0.0915 to 0.0321	1	\N
2020-06-29	FREQUENCY	CYP2C19	added *38	1	\N
2022-02-03	FREQUENCY	CYP2C9	Fixed population group values to match standard	1	\N
2017-06-19	FREQUENCY	DPYD	Added nucleotide and protein changes	1	\N
2017-06-28	FREQUENCY	DPYD	Added note about HapB3 and 1129-5923C>G	1	\N
2019-10-30	FREQUENCY	DPYD	Updated to new standardized format and weighted average allele frequencies. Combined information in ExAC allele number tab and previous references tab into new references tab. Converted to biogeographical groups	1	\N
2019-12-06	FREQUENCY	DPYD	Removed intronic and non-synonymous uncertain function variants: c.233+112G>T, c.234-93C>T, c.274C>G, c.484-145T>A, c.910T>C, c.1054C>G, c.1525-28A>G, c.1974+75A>G, c.2060A>C, c.2678A>G, c.2948C>T	1	\N
2020-02-24	FREQUENCY	DPYD	Removed c.151-69G>A; variant was originally assigned decreased function because of its LD with rs115232898 (Y186C), which has decreased function, but a functional impact of c.151-69G>A by itself is uncertain. Original comment: This variant was found to be in linkage disequilibrium (D'=1) with the decreased function variant rs115232898 (Y186C); the decreased function associated with this variant is likely due to this linkage.	1	\N
2020-02-24	FREQUENCY	DPYD	Removed c.680+139G>A; variant was originally assigned decreased function because of its possible connection with the Hap3B haplotype, which has decreased function, but a functional impact of c.680+139G>A by itself is uncertain. Original comment: Incomplete association with HapB3 (SNP not exclusive to HapB3 and therefore not a suitable proxy).	1	\N
2020-02-26	FREQUENCY	DPYD	Removed intronic normal function variants: c.1129-15T>C, c.763-118A>G, c.1740+39C>T, c.1740+40A>G, c.850+41T>C, c.958+134T>G, c.1340-106T>A, c.2300-39G>A, c.234-123G>C, c.850+91C>T, c.1129-28G>T, c.681-8C>T	1	\N
2021-06-22	RECOMMENDATION	RxNorm:32968	created	1	\N
2023-10-20	RECOMMENDATION	RxNorm:32968	took out "standard dose (75 mg/day)" for PM and likely PM recommendations (CVI) to match publication pdf text	1	\N
2020-07-14	RECOMMENDATION	RxNorm:27392	added AS AS 2.5, 3, 3.5, 4, ≥3, ≥3.25, ≥3.5, ≥4, ≥4.5, ≥5, ≥6 rows	1	\N
2023-05-10	RECOMMENDATION	RxNorm:27392	changed AS ≥4.5 to ≥3.75 and 3.5 to 2.75 duu to changes in the CYP2D6 allele function assignment	1	\N
2023-05-10	TEST_ALERT	RxNorm:3247	changed AS ≥4.5 to ≥3.75 and 3.5 to 2.75 duu to changes in the CYP2D6 allele function assignment	1	\N
2020-07-20	TEST_ALERT	RxNorm:3247	added rows for CYP2D6 AS: ≥6, ≥5, ≥4.5, ≥4, ≥3.5, ≥3.25, ≥3, 4, 3.5, 3, 2.5	1	\N
2020-07-21	TEST_ALERT	RxNorm:10154	split RYR1 or CACNA1S phenotyp and RYR1 or CACNA1S Activity score in one column per gene to match other two gene tables	1	\N
2021-09-08	TEST_ALERT	RxNorm:6572	created	1	\N
2021-09-08	TEST_ALERT	RxNorm:10207	created	1	\N
2019-09-19	ALLELE_DEFINITION	CYP2B6	The table represents the PharmVar core alleles (https://www.pharmvar.org/gene/CYP2B6) Version 4.1 Last Updated Sep 19 2019. Format change, function information removed.	1	\N
2020-09-14	ALLELE_DEFINITION	CYP2B6	Removed columns for the different structural variants and consolidated it in one column at the end of the table that lists PharmVar's description for the structural variants	1	\N
2020-12-06	ALLELE_DEFINITION	CYP2B6	Combined colums for g.41016810C>T and g.41016810C>A	1	\N
2021-03-30	ALLELE_DEFINITION	CYP2B6	*16 has been removed from PharmVar as a core allele and now is a suballele of *18, meaning that *18 may have an A or G at position 18053	1	\N
2021-04-23	ALLELE_DEFINITION	CYP2B6	update cell Z2 from 21034T>C to 21034C>T	1	\N
2023-03-02	ALLELE_DEFINITION	CYP2B6	added *39-*49	1	\N
2023-04-13	ALLELE_DEFINITION	CYP2B6	added protein change update to rs3745274	1	\N
2023-10-01	ALLELE_DEFINITION	CYP2B6	change in the hybrid name for *29 and *30	1	\N
2025-05-07	ALLELE_DEFINITION	CYP2B6	added *50	1	\N
2025-05-28	ALLELE_DEFINITION	CYP2B6	added rs2516199080	1	\N
2019-10-08	ALLELE_DEFINITION	NUDT15	Updated table format and added alleles to be consistent with PharmVar	1	\N
2020-02-13	ALLELE_DEFINITION	NUDT15	Updated the chromosome number	1	\N
2020-06-22	ALLELE_DEFINITION	NUDT15	Updated the *9 variant allele and position and the *2/*6 variant rsID to reflect the PharmVar definitions	1	\N
2020-06-24	ALLELE_DEFINITION	NUDT15	Updated *13, *15, *17 and *18 variant cDNA position to match PharmVar	1	\N
2020-08-17	ALLELE_DEFINITION	NUDT15	Added *20	1	\N
2020-08-26	ALLELE_DEFINITION	NUDT15	changed ref to del for *1 of insertion variants to match insertaton representation in other genes	1	\N
2020-12-08	ALLELE_DEFINITION	NUDT15	Fixed chromosomal location value for rs746071566 to use "g." prefix	1	\N
2021-10-01	FREQUENCY	G6PD	created version 1	1	\N
2022-04-04	FREQUENCY	G6PD	updated to include frequency for "Cairo" found in gnomAD v3.1.2	1	\N
2023-09-22	FREQUENCY	G6PD	Change "Telti/Kobe" to "Telti, Kobe" to avoid collision with diplotype syntax	1	\N
2020-08-11	RECOMMENDATION	RxNorm:2670	File created	1	\N
2020-12-09	RECOMMENDATION	RxNorm:2670	updated text in the implications field in PM row	1	\N
2023-05-10	RECOMMENDATION	RxNorm:2670	changed AS ≥4.5 to ≥3.75 and 3.5 to 2.75 duu to changes in the CYP2D6 allele function assignment	1	\N
2020-07-14	RECOMMENDATION	RxNorm:32937	added AS AS 2.5, 3, 3.5, 4, ≥3, ≥3.25, ≥3.5, ≥4, ≥4.5, ≥5, ≥6 rows	1	\N
2022-09-22	RECOMMENDATION	RxNorm:32937	updated recommendation to guideline update	1	\N
2023-04-18	RECOMMENDATION	RxNorm:32937	changed AS ≥4.5 to 3.75 and AS 3.5 to 2.75 because of the CYP2D6 functionailty assignment changes	1	\N
2023-05-10	TEST_ALERT	RxNorm:3638	changed AS ≥4.5 to ≥3.75 and 3.5 to 2.75 duu to changes in the CYP2D6 allele function assignment	1	\N
2020-07-20	TEST_ALERT	RxNorm:3638	added rows for CYP2D6 AS: ≥6, ≥5, ≥4.5, ≥4, ≥3.5, ≥3.25, ≥3, 4, 3.5, 3, 2.5	1	\N
2023-05-10	TEST_ALERT	RxNorm:10324	changed AS ≥4.5 to ≥3.75 and 3.5 to 2.75 duu to changes in the CYP2D6 allele function assignment	1	\N
2020-07-20	TEST_ALERT	RxNorm:10324	added rows for CYP2D6 AS: ≥6, ≥5, ≥4.5, ≥4, ≥3.5, ≥3.25, ≥3, 4, 3.5, 3, 2.5	1	\N
2024-03-20	TEST_ALERT	RxNorm:103	Updated for the following phenotypes: TPMT Intermediate Metabolizer/NUDT15 Intermediate Metabolizer, TPMT Intermediate Metabolizer/Possible NUDT15 Intermediate Metabolizer, Possible TPMT Intermediate Metabolizer/NUDT15 Intermediate Metabolizer, Possible TPMT Intermediate Metabolizer/Possible NUDT15 Intermediate Metabolizer	1	\N
2021-09-08	TEST_ALERT	RxNorm:2054023	created	1	\N
2019-09-19	ALLELE_DEFINITION	CYP2C19	change log created	1	\N
2019-09-19	ALLELE_DEFINITION	CYP2C19	allele function column removed	1	\N
2019-09-19	ALLELE_DEFINITION	CYP2C19	*36 and *37 added	1	\N
2020-06-29	ALLELE_DEFINITION	CYP2C19	added *38	1	\N
2020-09-14	ALLELE_DEFINITION	CYP2C19	Renamed column header for *37, which represents a partial gene deletion, and replaced it with 'structural variation' and list the PharmVar IDs for the structural variants	1	\N
2020-09-26	ALLELE_DEFINITION	CYP2C19	removed core allele only tab; added comment in notes	1	\N
2021-04-28	ALLELE_DEFINITION	CYP2C19	romoved "delgene" text from *36	1	\N
2021-05-06	ALLELE_DEFINITION	CYP2C19	Moved *38 as reference as this allele matches the human genome CYP2C19 Reference sequence LRG_584 / NG_008384.3.	1	\N
2021-05-06	ALLELE_DEFINITION	CYP2C19	added *39	1	\N
2022-03-24	ALLELE_DEFINITION	CYP2C19	added p.expression in NP field for -806C>T	1	\N
2022-10-03	ALLELE_DEFINITION	CYP2C19	replaced PharmVAR IDs for *38, *5, *7, *8, *16, *30, *34	1	\N
2022-10-03	ALLELE_DEFINITION	CYP2C19	added g.94842866A>G to *5, *7, *8	1	\N
2025-06-16	ALLELE_DEFINITION	CYP2C19	added *40, *41	1	\N
2021-07-09	ALLELE_DEFINITION	NUDT15	update the deletion bases for *9	1	\N
2021-09-03	ALLELE_DEFINITION	NUDT15	PharmVar introduced core allele definitions for NUDT15, 502G>A was removed from *20	1	\N
2021-09-03	ALLELE_DEFINITION	NUDT15	based on the PharmVar API content columns for 50delGAGTCG and 55_56insGAGTCG are combined for rs746071566 and the variant representation changed, content starting D11 to the right	1	\N
2021-09-03	ALLELE_DEFINITION	NUDT15	added p. in front of amino acid change	1	\N
2021-09-03	ALLELE_DEFINITION	NUDT15	removed nucleotide A from headers in row 2, 4, 5 for rs1457579126	1	\N
2021-09-03	ALLELE_DEFINITION	NUDT15	based on the PharmVar API content for rs761191455 the following was changed: 342_343insG, E115Frameshift, g.48041103_48041104insG, g.8537_8538insG, reference cell: del, variant cell: insG to 343dup, p.E115fs, g.48041104dup, g.8538dup, reference cell: G, variant cell: GG	1	\N
2021-10-13	ALLELE_DEFINITION	NUDT15	added link to the PharmVar NUDT15 page on Notes tab	1	\N
2019-09-19	FREQUENCY	HLA-A	version 1 created from existing data in former HLA allele frequency table, new references added, duplicate references removed, frequencies calculated using weighted averages and PharmGKB biogeographical groups applied	1	\N
2020-02-27	FREQUENCY	HLA-A	Added PMID 30127801 to references, updated information on biogeographical groups on methods tab	1	\N
2020-07-20	RECOMMENDATION	RxNorm:27340	created log	1	\N
2023-08-29	RECOMMENDATION	RxNorm:27340	added combinations of CACNA1S and RYR1	1	\N
2023-11-15	RECOMMENDATION	RxNorm:27340	added note about biallelic (homozygous or compound heterozygous) pathogenic variants in CACNA1S to cell I3, I5, and I7	1	\N
2023-12-05	RECOMMENDATION	RxNorm:27340	uploaded to CPIC db	1	\N
2021-06-28	RECOMMENDATION	RxNorm:8183	Fix typo for HLA-B "No Result" value	1	\N
2020-07-21	TEST_ALERT	RxNorm:3920	split RYR1 or CACNA1S phenotyp and RYR1 or CACNA1S Activity score in one column per gene to match other two gene tables	1	\N
2023-05-10	TEST_ALERT	RxNorm:10834	changed AS ≥4.5 to ≥3.75 and 3.5 to 2.75 duu to changes in the CYP2D6 allele function assignment	1	\N
2020-07-20	TEST_ALERT	RxNorm:10834	added rows for CYP2D6 AS: ≥6, ≥5, ≥4.5, ≥4, ≥3.5, ≥3.25, ≥3, 4, 3.5, 3, 2.5	1	\N
2021-09-08	TEST_ALERT	RxNorm:6878	created	1	\N
2024-03-20	TEST_ALERT	RxNorm:10485	Updated for the following phenotypes: TPMT Intermediate Metabolizer/NUDT15 Intermediate Metabolizer, TPMT Intermediate Metabolizer/Possible NUDT15 Intermediate Metabolizer, Possible TPMT Intermediate Metabolizer/NUDT15 Intermediate Metabolizer, Possible TPMT Intermediate Metabolizer/Possible NUDT15 Intermediate Metabolizer	1	\N
2017-01-15	FREQUENCY	HLA-B	version 1	1	\N
2017-08-11	FREQUENCY	HLA-B	update 57:01 and 58:01 frequencies	1	\N
2019-09-19	FREQUENCY	HLA-B	Removed HLA-A*31:01 to create HLA-B frequency table. Added new references, removed duplicate references, calculated weighted average frequencies and applied PharmGKB biogeographical groups.	1	\N
2020-02-27	FREQUENCY	HLA-B	Added PMID 30127801 to references. Updated information about biogeographical groups on methods tab	1	\N
2020-07-20	RECOMMENDATION	RxNorm:3920	created log	1	\N
2023-08-29	RECOMMENDATION	RxNorm:3920	added combinations of CACNA1S and RYR1	1	\N
2023-11-15	RECOMMENDATION	RxNorm:3920	added note about biallelic (homozygous or compound heterozygous) pathogenic variants in CACNA1S to cell I3, I5, and I7	1	\N
2023-12-05	RECOMMENDATION	RxNorm:3920	uploaded to CPIC db	1	\N
2021-06-28	RECOMMENDATION	RxNorm:72236	Fix typo for HLA-B "No Result" value	1	\N
2023-08-01	TEST_ALERT	RxNorm:321988	fixed typo	1	\N
2021-09-08	TEST_ALERT	RxNorm:7833	created	1	\N
2021-09-08	TEST_ALERT	RxNorm:7240	created	1	\N
2021-09-08	TEST_ALERT	RxNorm:10635	created	1	\N
2025-03-06	ALLELE_DEFINITION	NUDT15	*21 added	1	\N
2019-10-09	ALLELE_FUNCTION_REFERENCE	CACNA1S	Updated to new format.	1	\N
2019-10-11	ALLELE_FUNCTION_REFERENCE	CACNA1S	Updated table notes	1	\N
2020-06-11	ALLELE_FUNCTION_REFERENCE	CACNA1S	Added reference row and normal function	1	\N
2020-07-07	ALLELE_FUNCTION_REFERENCE	CACNA1S	Changed column B header to "Activity Value"	1	\N
2019-10-09	ALLELE_FUNCTION_REFERENCE	CYP3A5	Updated to new format. Added new alleles from PharmVar	1	\N
2022-02-15	ALLELE_FUNCTION_REFERENCE	CYP3A5	Removed *2, *4, *5 rows based on the CYP3A5 allele definition update (all had unknown function assigned)	1	\N
2021-03-03	FREQUENCY	MT-RNR1	File created	1	\N
2023-12-20	FREQUENCY	MT-RNR1	Added "m." prefix to allele names	1	\N
2020-07-20	RECOMMENDATION	RxNorm:5095	created log	1	\N
2023-08-29	RECOMMENDATION	RxNorm:5095	added combinations of CACNA1S and RYR1	1	\N
2023-11-15	RECOMMENDATION	RxNorm:5095	added note about biallelic (homozygous or compound heterozygous) pathogenic variants in CACNA1S to cell I3, I5, and I7	1	\N
2023-12-05	RECOMMENDATION	RxNorm:5095	uploaded to CPIC db	1	\N
2020-07-15	RECOMMENDATION	RxNorm:36567	added SLCO1B1 possible increased function row	1	\N
2022-02-01	RECOMMENDATION	RxNorm:36567	updated recommendation based on CPIC statin guideline included simvastatin update	1	\N
2021-08-02	TEST_ALERT	RxNorm:41127	created	1	\N
2021-09-08	TEST_ALERT	RxNorm:1191	created	1	\N
2021-09-08	TEST_ALERT	RxNorm:7454	created	1	\N
2021-09-08	TEST_ALERT	RxNorm:10638	created	1	\N
2019-09-05	ALLELE_DEFINITION	CYP2C9	The table represents the PharmVar core alleles (https://www.pharmvar.org/gene/CYP2C9) Version 4.0 Last Updated May 7 2019. Format change, function information removed.	1	\N
2020-06-08	ALLELE_DEFINITION	CYP2C9	Added *62	1	\N
2020-07-06	ALLELE_DEFINITION	CYP2C9	corrected 395G>A* to g.8598G>A in V5	1	\N
2020-07-06	ALLELE_DEFINITION	CYP2C9	added 'g.' to BF5 location	1	\N
2020-07-06	ALLELE_DEFINITION	CYP2C9	changed g.15625delA to g.15626delA according to PharmVar and dbSNP	1	\N
2021-01-21	ALLELE_DEFINITION	CYP2C9	added *63-*70	1	\N
2021-01-21	ALLELE_DEFINITION	CYP2C9	CPIC file still uses CYP2C9 RefSeqGene - NG_008385.1; PharmVar uses CYP2C9 RefSeqGene (LRG_1195) - NG_008385.2, which has different position numbers due to the different lengths of the NG sequences	1	\N
2021-05-04	ALLELE_DEFINITION	CYP2C9	Changed file to use RefSeq NG_008385.2 positions, updated allele definitions and added new allele *71 from PharmVar	1	\N
2021-06-11	ALLELE_DEFINITION	CYP2C9	changed R144H to R144C for 3608C>T	1	\N
2021-09-02	ALLELE_DEFINITION	CYP2C9	changed column headers for rs1304490498 from 3531delAGAAATGGAA, p.118fs, g.94942213delAGAAATGGAA, g.9056delAGAAATGGAA to 3531_3540del, p.K118fs, g.94942213_94942222del, g.9056_9065del based on PharmVar API content	1	\N
2021-09-02	ALLELE_DEFINITION	CYP2C9	removed A from column headers in row 2, 4, 5 for rs9332131 based on PharmVar API content	1	\N
2022-01-04	ALLELE_DEFINITION	CYP2C9	added *72-*75	1	\N
2022-04-19	ALLELE_DEFINITION	CYP2C9	added *76-*85	1	\N
2022-05-04	ALLELE_DEFINITION	CYP2C9	mapping of *74 changed at PharmVar PV01740Replaced by PV01803 (corresponds to change from 8757G>T to 9257G>T both listed as Q214H)	1	\N
2025-05-28	ALLELE_DEFINITION	CYP2C9	rs1216169538'; rs2493006942; rs761033063; rs2492587526; rs2492591692; rs2492634549; rs2492650213'; rs2492662738; rs2492662839	1	\N
2025-06-16	ALLELE_DEFINITION	CYP2C9	added *86-*88	1	\N
2023-12-05	ALLELE_DEFINITION	RYR1	File was updated to include the RYR1 variants from supplemental table S2 of the ClinGen RYR1 VCEP publication 35849058 (see Notes tab)	1	\N
2022-08-06	ALLELE_DEFINITION	RYR1	rs113812662 is obsolete; rs113422327 is obsolete both taken out of file	1	\N
2020-10-09	ALLELE_DEFINITION	RYR1	changed c.7039_7041delGAG or c.7042_7044delGAG name to c.7042_7044delGAG to reflect naming as on the EMHG list and used mapping data that correspond with the rsID in dbSNP	1	\N
2020-09-22	ALLELE_DEFINITION	RYR1	chromosomal and Ref sequence change for R163L - changed G>A to G>T; ref sequence for R614L entered as g.28847G>T	1	\N
2020-09-22	ALLELE_DEFINITION	RYR1	changed ambiguous nucleotides in headers to two sequences, e.g. NC_000019.10:g.38446710G>M to g.38446710G>C; g.38446710G>A	1	\N
2019-10-08	ALLELE_DEFINITION	RYR1	Updated format, removed function column	1	\N
2019-08-15	ALLELE_DEFINITION	RYR1	Added change log tab	1	\N
2019-04-19	ALLELE_FUNCTION_REFERENCE	CFTR	Added change log tab	1	\N
2019-10-10	ALLELE_FUNCTION_REFERENCE	CFTR	Updated format	1	\N
2019-10-11	ALLELE_FUNCTION_REFERENCE	CFTR	Updated table notes	1	\N
2020-03-04	ALLELE_FUNCTION_REFERENCE	CFTR	Took out G85E since not part of recommendations, was included in the incidential finding table in the guideline supplement	1	\N
2020-03-04	ALLELE_FUNCTION_REFERENCE	CFTR	Added F508del(TCT)	1	\N
2020-03-09	ALLELE_FUNCTION_REFERENCE	CFTR	Added comment for F508del variants	1	\N
2020-03-09	ALLELE_FUNCTION_REFERENCE	CFTR	Removed ivacaftor non-responsive function from reference	1	\N
2020-03-09	ALLELE_FUNCTION_REFERENCE	CFTR	removed 711+1G->T/ Class: I and added 711+3A->G as later is on the ivacaftor drug label	1	\N
2020-05-22	ALLELE_FUNCTION_REFERENCE	CFTR	removed F508del variant	1	\N
2020-05-26	ALLELE_FUNCTION_REFERENCE	CFTR	replaced reference with "ivacaftor non-responsive CFTR sequence"	1	\N
2024-01-11	ALLELE_FUNCTION_REFERENCE	DPYD	Added c.1129-5923C>G as a single allele in addition to the HapB3 allele; and PMID plus findings to reference row	1	\N
2020-04-28	ALLELE_FUNCTION_REFERENCE	DPYD	Removed comments from c.3067C>A.	1	\N
2019-10-09	ALLELE_FUNCTION_REFERENCE	UGT1A1	Updated to new format	1	\N
2020-07-07	ALLELE_FUNCTION_REFERENCE	UGT1A1	Changed column B header to "Activity Value"	1	\N
2018-01-20	FREQUENCY	NUDT15	Version 1 created	1	\N
2018-04-20	FREQUENCY	NUDT15	updated frequencies and sources	1	\N
2018-04-27	FREQUENCY	NUDT15	removed *3 and *6 frequencies from references where *2 was not calculated	1	\N
2018-06-13	FREQUENCY	NUDT15	updated some wording on methods tab	1	\N
2018-06-18	FREQUENCY	NUDT15	updated frequency of *3 allele for African from Moriyama	1	\N
2019-01-12	FREQUENCY	NUDT15	updated diplotype and phenotype frequencies	1	\N
2019-01-25	FREQUENCY	NUDT15	updated phenotype frequencies	1	\N
2019-03-05	FREQUENCY	NUDT15	updated phenotype frequencies with change for *9 from unknown function to no function	1	\N
2019-10-18	FREQUENCY	NUDT15	updated allele names on References tab to match Allele frequency by race tab	1	\N
2019-10-25	FREQUENCY	NUDT15	Converted to biogeographical groups and weighted allele frequencies. Updated document to new standardized format	1	\N
2022-03-11	FREQUENCY	NUDT15	fixed diplotpye/phenotype calculations and made layouts consistent	1	\N
2020-07-20	RECOMMENDATION	RxNorm:6026	created log	1	\N
2023-08-29	RECOMMENDATION	RxNorm:6026	added combinations of CACNA1S and RYR1	1	\N
2023-11-15	RECOMMENDATION	RxNorm:6026	added note about biallelic (homozygous or compound heterozygous) pathogenic variants in CACNA1S to cell I3, I5, and I7	1	\N
2023-12-05	RECOMMENDATION	RxNorm:6026	uploaded to CPIC db	1	\N
2020-07-14	RECOMMENDATION	RxNorm:10324	added AS AS 2.5, 3, 3.5, 4, ≥3, ≥3.25, ≥3.5, ≥4, ≥4.5, ≥5, ≥6 rows	1	\N
2023-05-10	RECOMMENDATION	RxNorm:10324	changed AS ≥4.5 to ≥3.75 and 3.5 to 2.75 duu to changes in the CYP2D6 allele function assignment	1	\N
2020-07-21	TEST_ALERT	RxNorm:5095	split RYR1 or CACNA1S phenotyp and RYR1 or CACNA1S Activity score in one column per gene to match other two gene tables	1	\N
2023-05-10	TEST_ALERT	RxNorm:38400	changed AS ≥4.5 to ≥3.75 and 3.5 to 2.75 duu to changes in the CYP2D6 allele function assignment	1	\N
2019-09-19	ALLELE_DEFINITION	CYP2D6	created change log	1	\N
2019-09-19	ALLELE_DEFINITION	CYP2D6	removed allele function column and function related notes	1	\N
2019-09-19	ALLELE_DEFINITION	CYP2D6	added alleles up to *139	1	\N
2019-10-28	ALLELE_DEFINITION	CYP2D6	removed rsID from 3278T>C variant in *26	1	\N
2020-03-02	ALLELE_DEFINITION	CYP2D6	added Y into *4 at position g.42127526C>T	1	\N
2020-03-04	ALLELE_DEFINITION	CYP2D6	took out R at g.42130692G>A in *56 in the "core alleles" tab since this tab reflects the core allele defintion as presented on PharmVar	1	\N
2020-05-30	ALLELE_DEFINITION	CYP2D6	CNVs taken out since those will be handeled through the db	1	\N
2020-09-14	ALLELE_DEFINITION	CYP2D6	Removed columns for the different strutural variant changes in CYP2D6 and replaced it with one column that lists the PharmVar IDs for the structural variants	1	\N
2020-09-26	ALLELE_DEFINITION	CYP2D6	Removed core allele only tab, added comment to Notes	1	\N
2020-10-08	ALLELE_DEFINITION	CYP2D6	*140 and *141	1	\N
2021-01-21	ALLELE_DEFINITION	CYP2D6	*128 changed variant allele from G to C (GRCH38)	1	\N
2021-01-21	ALLELE_DEFINITION	CYP2D6	added *142 to *145	1	\N
2021-01-21	ALLELE_DEFINITION	CYP2D6	changed variant for *124 from 3810_3811insTC to 3810delTC (as per PharmVar website 1/21/21 -Corrected in v4.1.9 3810ins TC was corrected to 3810_3811delTC)	1	\N
2021-01-21	ALLELE_DEFINITION	CYP2D6	variant in *18, position moved from 4133_4134insGTGCCCACT to 4134_4135insGTGCCCACT and 42126666_42126667insAGTGGGCAC to g.42126657_42126658insAGTGGGCAC (per PharmVar Corrected in v.4.2.3 4133_4134insGTGCCCACT was corrected to 4134_4135insGTGCCCACT)	1	\N
2021-02-17	ALLELE_DEFINITION	CYP2D6	combined the two 1721 columns into one column	1	\N
2021-04-14	ALLELE_DEFINITION	CYP2D6	corrected nucleotides for *114 to C in reference row and T in *144 row to align with GRCh38 nucleotides	1	\N
2021-05-07	ALLELE_DEFINITION	CYP2D6	update to NG_008376.4 in row 5 which moves all positions compared to NG_008376.3	1	\N
2021-05-07	ALLELE_DEFINITION	CYP2D6	took out delGene from *5, gene deletion is reflected through PVID	1	\N
2021-05-07	ALLELE_DEFINITION	CYP2D6	changed Frameshift to 'amino acid position' fs for the frameshift causing variants	1	\N
2021-05-07	ALLELE_DEFINITION	CYP2D6	added 1662G>C; This is a synonymous variant that is present in most alleles but in *29 and *70 this variant together with 1660G>A results in an amino acid change from V136I instead of the V136M of 1660G>A by itself	1	\N
2021-05-07	ALLELE_DEFINITION	CYP2D6	changed 3260_3261insGT to 3261_3262insGT and g.42127533_42127534insAC to g.42127530_42127531insAC	1	\N
2021-05-07	ALLELE_DEFINITION	CYP2D6	changed rsID for 4073G>A to rs200965026	1	\N
2021-05-07	ALLELE_DEFINITION	CYP2D6	changed A431G to A482G	1	\N
2021-05-07	ALLELE_DEFINITION	CYP2D6	deleted T variant at position 2989G>A in *132	1	\N
2021-05-18	ALLELE_DEFINITION	CYP2D6	replaced rs200965026 with rs369177208	1	\N
2021-05-18	ALLELE_DEFINITION	CYP2D6	added p. infront of amino acid change	1	\N
2021-05-24	ALLELE_DEFINITION	CYP2D6	changed p.H478N to p.H478Y	1	\N
2021-08-19	ALLELE_DEFINITION	CYP2D6	changed S to G at position g.42129130 for all allele in which all suballeles have the variant alleles, see notes for further detail	1	\N
2021-10-01	ALLELE_DEFINITION	CYP2D6	changed g.42130728delG to g.42130729del per PharmVar API content; removed C in other headers for that variant	1	\N
2021-10-01	ALLELE_DEFINITION	CYP2D6	changed 137_138insT to 137dup and g.42130655_42130656insA to g.42130655dup and g.5156_5157insT to g.5156dup; reference cell from del to A and variant cell from insA to AA	1	\N
2021-10-01	ALLELE_DEFINITION	CYP2D6	removed letter after del in header positions for 1708delT	1	\N
2018-04-23	ALLELE_DEFINITION	SLCO1B1	Added change log tab	1	\N
2019-10-08	ALLELE_DEFINITION	SLCO1B1	Updated format, removed function column	1	\N
2021-10-05	GENE_CDS	ABCG2	created	1	\N
2018-06-13	FREQUENCY	CYP2B6	Version 1 created	1	\N
2020-07-20	TEST_ALERT	RxNorm:38400	added rows for CYP2D6 AS: ≥6, ≥5, ≥4.5, ≥4, ≥3.5, ≥3.25, ≥3, 4, 3.5, 3, 2.5	1	\N
2021-09-08	TEST_ALERT	RxNorm:7517	created	1	\N
2023-05-10	TEST_ALERT	RxNorm:10689	added rows for CYP2D6 AS: ≥6, ≥5, ≥3.75, ≥4, ≥3.5, ≥3.25, ≥3, 4, 2.75, 3, 2.5	1	\N
2024-02-14	FREQUENCY	RYR1	Gnomad v3 frequencies added	1	\N
2023-12-05	FREQUENCY	RYR1	File was updated to include the RYR1 variants from supplemental table S2 of the ClinGen RYR1 VCEP publication 35849058 (see Methods tab)	1	\N
2020-10-09	FREQUENCY	RYR1	changed c.7039_7041delGAG or c.7042_7044delGAG name to c.7042_7044delGAG to reflect naming as on the EMHG list and used mapping data that correspond with the rsID in dbSNP	1	\N
2019-12-09	FREQUENCY	RYR1	Removed rsID and protein change columns from Allele frequency sheet. Changed rsIDs on Reference sheet to equivalent nucleotide changes	1	\N
2019-10-28	FREQUENCY	RYR1	Converted to PharmGKB biogeographical groups, added References, Methods and Change Log sheets. Average allele frequencies now calculated using weighted averages.	1	\N
2020-07-20	RECOMMENDATION	RxNorm:6857	created log	1	\N
2023-08-29	RECOMMENDATION	RxNorm:6857	added combinations of CACNA1S and RYR1	1	\N
2023-11-15	RECOMMENDATION	RxNorm:6857	added note about biallelic (homozygous or compound heterozygous) pathogenic variants in CACNA1S to cell I3, I5, and I7	1	\N
2023-12-05	RECOMMENDATION	RxNorm:6857	uploaded to CPIC db	1	\N
2024-03-20	RECOMMENDATION	RxNorm:10485	Updated for the following phenotypes: TPMT Intermediate Metabolizer/NUDT15 Intermediate Metabolizer, TPMT Intermediate Metabolizer/Possible NUDT15 Intermediate Metabolizer, Possible TPMT Intermediate Metabolizer/NUDT15 Intermediate Metabolizer, Possible TPMT Intermediate Metabolizer/Possible NUDT15 Intermediate Metabolizer	1	\N
2020-07-14	RECOMMENDATION	RxNorm:10485	log created	1	\N
2023-05-10	TEST_ALERT	RxNorm:5691	changed AS ≥4.5 to ≥3.75 and 3.5 to 2.75 duu to changes in the CYP2D6 allele function assignment	1	\N
2020-07-20	TEST_ALERT	RxNorm:5691	added rows for CYP2D6 AS: ≥6, ≥5, ≥4.5, ≥4, ≥3.5, ≥3.25, ≥3, 4, 3.5, 3, 2.5	1	\N
2024-03-20	TEST_ALERT	RxNorm:1256	Updated for the following phenotypes: TPMT Intermediate Metabolizer/NUDT15 Intermediate Metabolizer, TPMT Intermediate Metabolizer/Possible NUDT15 Intermediate Metabolizer, Possible TPMT Intermediate Metabolizer/NUDT15 Intermediate Metabolizer, Possible TPMT Intermediate Metabolizer/Possible NUDT15 Intermediate Metabolizer	1	\N
2024-05-09	TEST_ALERT	RxNorm:1256	Updated text for NUDT15 PM to reduce dose by 10x	1	\N
2021-09-08	TEST_ALERT	RxNorm:7623	created	1	\N
2023-05-10	TEST_ALERT	RxNorm:27392	changed AS ≥4.5 to ≥3.75 and 3.5 to 2.75 duu to changes in the CYP2D6 allele function assignment	1	\N
2020-07-20	TEST_ALERT	RxNorm:27392	added rows for CYP2D6 AS: ≥6, ≥5, ≥4.5, ≥4, ≥3.5, ≥3.25, ≥3, 4, 3.5, 3, 2.5	1	\N
2022-03-11	FREQUENCY	SLCO1B1	fixed diplotpye/phenotype calculations and made layouts consistent	1	\N
2021-11-10	FREQUENCY	SLCO1B1	Added new alleles *48, *49	1	\N
2021-09-21	FREQUENCY	SLCO1B1	Updated allele table based on PharmVar SLCO1B1 release	1	\N
2019-10-29	FREQUENCY	SLCO1B1	Updated document to new standardized format and weighted average allele frequencies. Added all alleles from Allele Definition file and converted to biogeographical groups.	1	\N
2017-02-13	FREQUENCY	SLCO1B1	updated footnotes	1	\N
2016-02-09	FREQUENCY	SLCO1B1	Created version 1	1	\N
2020-07-20	RECOMMENDATION	RxNorm:36453	created log	1	\N
2023-08-29	RECOMMENDATION	RxNorm:36453	added combinations of CACNA1S and RYR1	1	\N
2023-11-15	RECOMMENDATION	RxNorm:36453	added note about biallelic (homozygous or compound heterozygous) pathogenic variants in CACNA1S to cell I3, I5, and I7	1	\N
2023-12-05	RECOMMENDATION	RxNorm:36453	uploaded to CPIC db	1	\N
2020-08-11	RECOMMENDATION	RxNorm:10689	File created	1	\N
2023-05-10	RECOMMENDATION	RxNorm:10689	changed AS ≥4.5 to ≥3.75 and 3.5 to 2.75 duu to changes in the CYP2D6 allele function assignment	1	\N
2020-07-21	TEST_ALERT	RxNorm:6026	split RYR1 or CACNA1S phenotyp and RYR1 or CACNA1S Activity score in one column per gene to match other two gene tables	1	\N
2021-09-08	TEST_ALERT	RxNorm:2348	created	1	\N
2021-10-01	ALLELE_DEFINITION	CYP2D6	changed 1864_1865insTTTCGCCCC; 1856_1857insTTTCGCCCCTTTCGCCCC to 1864_1865TTTCGCCCC[3]; 1856_1857dup; 1856_1864dup and g.42128936_42128937insGGGGCGAAA; g.42128936_42128937insGGGGCGAAAGGGGCGAAA to g.42128934AAAGGGGCG[3]; g.42128934_42128942dup and g.6883_6884insTTTCGCCCC; g.6883_6884insTTTCGCCCCTTTCGCCCC to g.6875_6883dup, g.6875TTTCGCCCC[3] and refrence cell from del to AAAGGGGCG and *30, *58, *145 variant cell from insGGGGCGAAA to AAAGGGGCGAAAGGGGCG; *40 variant cell from insGGGGCGAAAGGGGCGAAA to AAAGGGGCG(3)	1	\N
2021-10-01	ALLELE_DEFINITION	CYP2D6	changed 1977_1978insG to 1977dup and g.42128817_42128818insC to g.42128817dup and g.6996_6997insG to g.6996dup and refernec cell dec to C and varinat cell insC to CC	1	\N
2021-10-01	ALLELE_DEFINITION	CYP2D6	removed letter after del in header positions for 1996delC	1	\N
2023-08-03	GENE_CDS	CYP2D6	updated description due to *41 activity value change	1	\N
2021-09-08	TEST_ALERT	RxNorm:1011650	created	1	\N
2021-09-08	TEST_ALERT	RxNorm:1151	created	1	\N
2018-01-29	FREQUENCY	TPMT	Version 1 created	1	\N
2018-04-20	FREQUENCY	TPMT	updated frequencies and sources	1	\N
2018-04-25	FREQUENCY	TPMT	updated *41 and *22 frequencies; corrected typo in footnote	1	\N
2018-04-26	FREQUENCY	TPMT	keeping refs with frequencies with *3A calculated for *3A, *3B, *3C	1	\N
2018-06-13	FREQUENCY	TPMT	updated some wording on methods tab & URL in footnote on Allele Frequency by Race tab	1	\N
2019-10-29	FREQUENCY	TPMT	Updated to standardized format and weighted average allele frequencies. Converted to biogeographical groups.	1	\N
2022-03-11	FREQUENCY	TPMT	fixed diplotpye/phenotype calculations and made layouts consistent	1	\N
2020-07-20	RECOMMENDATION	RxNorm:10154	created log	1	\N
2023-08-29	RECOMMENDATION	RxNorm:10154	added combinations of CACNA1S and RYR1	1	\N
2023-11-15	RECOMMENDATION	RxNorm:10154	added note about biallelic (homozygous or compound heterozygous) pathogenic variants in CACNA1S to cell I3, I5, and I7	1	\N
2023-12-05	RECOMMENDATION	RxNorm:10154	uploaded to CPIC db	1	\N
2020-07-14	RECOMMENDATION	RxNorm:10834	added AS AS 2.5, 3, 3.5, 4, ≥3, ≥3.25, ≥3.5, ≥4, ≥4.5, ≥5, ≥6 rows	1	\N
2021-10-01	ALLELE_DEFINITION	CYP2D6	changed 2540delAACT to 2540_2543del and g.42128249delAGTT to g.42128251_42128254del and g.7559delAACT to g.7559_7562del and reference cell from AGTT to TTAG and variant cells from delAGTT to delTTAG	1	\N
2021-10-01	ALLELE_DEFINITION	CYP2D6	removed letter after del in header positions for 2550delA	1	\N
2021-10-01	ALLELE_DEFINITION	CYP2D6	changed 2580_2581insC to 2580dup and g.42128218_42128219insG to g.42128218dup and g.7599_7600insC to g.7599dup and reference cell from del to G and variant cell from insG to GG	1	\N
2021-10-01	ALLELE_DEFINITION	CYP2D6	changed 2588delGACT to 2586CTGA[1] and g.42128201delAGTC to g.42128199TCAG[1] and g.7607delGACT to g.7605CTGA[1] and reference cell from AGTC to TCAG(2) and variant cell from delAGTC to TCAG(1)	1	\N
2021-10-01	ALLELE_DEFINITION	CYP2D6	changed 2616delAAG to 2616_2618del and g.42128174delCTT to g.42128176_42128178del and g.7635delAAG to g.7635_7637del and reference cell from CTT to TCT and variant cell from delCTT to delTCT	1	\N
2021-10-01	ALLELE_DEFINITION	CYP2D6	removed letter after del in header positions for 2829delC	1	\N
2023-05-10	RECOMMENDATION	RxNorm:10834	changed AS ≥4.5 to ≥3.75 and 3.5 to 2.75 duu to changes in the CYP2D6 allele function assignment	1	\N
2021-07-30	TEST_ALERT	RxNorm:6472	Deleted possible phenotypes and increased function; updated CDS alerts text to reflect recommendations in 2021 guideline	1	\N
2020-07-15	TEST_ALERT	RxNorm:6472	added row for possible increased function	1	\N
2021-09-08	TEST_ALERT	RxNorm:2393	created	1	\N
2021-09-08	TEST_ALERT	RxNorm:8120	created	1	\N
2021-09-08	TEST_ALERT	RxNorm:11258	created	1	\N
2017-02-08	FREQUENCY	UGT1A1	Alie Fohner created v 1	1	\N
2019-10-18	FREQUENCY	UGT1A1	updated allele names to match names in allele defintion file, and removed extraneous variant not found in definition and function files	1	\N
2019-10-29	FREQUENCY	UGT1A1	Updated document to new standardized format and weighted average allele frequencies. Added Methods tab and converted to biogeographical groups.	1	\N
2020-01-08	FREQUENCY	UGT1A1	Corrected typo on Allele frequency sheet	1	\N
2022-03-11	FREQUENCY	UGT1A1	fixed diplotpye/phenotype calculations and made layouts consistent	1	\N
2020-07-14	RECOMMENDATION	RxNorm:3247	added AS AS 2.5, 3, 3.5, 4, ≥3, ≥3.25, ≥3.5, ≥4, ≥4.5, ≥5, ≥6 rows	1	\N
2023-05-10	RECOMMENDATION	RxNorm:3247	changed AS ≥4.5 to ≥3.75 and 3.5 to 2.75 duu to changes in the CYP2D6 allele function assignment	1	\N
2022-09-20	RECOMMENDATION	RxNorm:39786	created	1	\N
2023-04-18	RECOMMENDATION	RxNorm:39786	changed AS ≥4.5 to 3.75 and AS 3.5 to 2.75 because of the CYP2D6 functionailty assignment changes	1	\N
2020-07-21	TEST_ALERT	RxNorm:6857	split RYR1 or CACNA1S phenotyp and RYR1 or CACNA1S Activity score in one column per gene to match other two gene tables	1	\N
2021-09-08	TEST_ALERT	RxNorm:2551	created	1	\N
2021-09-08	TEST_ALERT	RxNorm:8687	created	1	\N
2025-08-13	GENE_CDS	HLA-A	added gene symbol as a prefix to the phenotype column values	1	\N
2021-10-01	ALLELE_DEFINITION	CYP2D6	changed 2928delGATCCTACATCCGGATGTG to 2928_2936del and g.42127846delCACATCCGGATGTAGGATC to g.42127846_42127864del and g.7947delGATCCTACATCCGGATGTG to g.7947_7965del	1	\N
2021-10-01	ALLELE_DEFINITION	CYP2D6	changed 3810delTC to 3810_3811del and g.42126981delGA to g.42126982_42126983del and g.8829delTC to g.8829_8830del and reference cell from GA to AG and variant cell from del GA to delAG	1	\N
2021-10-01	ALLELE_DEFINITION	CYP2D6	added rs1931013246	1	\N
2021-10-01	ALLELE_DEFINITION	CYP2D6	changed g.9153_9154insGTGCCCACT to g.9146_9154dup and 4134_4135insGTGCCCACT to 4127_4135dup and g.42126657_42126658insAGTGGGCAC to g.42126658_42126666dup and reference cell from del to AGTGGGCAC and variant cell from insAGTGGGCAC to AGTGGGCACAGTGGGCAC	1	\N
2025-08-13	GENE_CDS	G6PD	added gene symbol as a prefix to the phenotype column values	1	\N
2025-08-13	GENE_CDS	CACNA1S	added gene symbol as a prefix to the phenotype column values	1	\N
2025-08-13	GENE_CDS	TPMT	added gene symbol as a prefix to the phenotype column values	1	\N
2025-08-13	GENE_CDS	RYR1	added gene symbol as a prefix to the phenotype column values	1	\N
2025-08-13	GENE_CDS	CYP2B6	added gene symbol as a prefix to the phenotype column values	1	\N
2025-08-13	GENE_CDS	CYP3A5	added gene symbol as a prefix to the phenotype column values	1	\N
2025-08-13	GENE_CDS	ABCG2	added gene symbol as a prefix to the phenotype column values	1	\N
2025-08-13	GENE_CDS	SLCO1B1	added gene symbol as a prefix to the phenotype column values	1	\N
2025-08-13	GENE_CDS	DPYD	added gene symbol as a prefix to the phenotype column values	1	\N
2025-08-13	GENE_CDS	MT-RNR1	added gene symbol as a prefix to the phenotype column values	1	\N
2025-08-13	GENE_CDS	CYP2D6	added gene symbol as a prefix to the phenotype column values	1	\N
2025-08-13	GENE_CDS	CYP2C19	added gene symbol as a prefix to the phenotype column values	1	\N
2025-08-13	GENE_CDS	HLA-B	added gene symbol as a prefix to the phenotype column values	1	\N
2025-08-13	GENE_CDS	NUDT15	added gene symbol as a prefix to the phenotype column values	1	\N
2025-08-13	GENE_CDS	UGT1A1	added gene symbol as a prefix to the phenotype column values	1	\N
2025-08-13	GENE_CDS	CYP2C9	added gene symbol as a prefix to the phenotype column values	1	\N
2019-10-28	FREQUENCY	VKORC1	Updated to new standardized format and weighted average allele frequencies. Converted to biogeographical groups. Removed references with no information on rs9923231	1	\N
2019-10-18	FREQUENCY	VKORC1	updated allele name to match allele defintion table	1	\N
2017-02-13	FREQUENCY	VKORC1	updated footnotes	1	\N
2016-09-08	FREQUENCY	VKORC1	Li Gong created version 1	1	\N
2020-07-14	RECOMMENDATION	RxNorm:3638	added AS AS 2.5, 3, 3.5, 4, ≥3, ≥3.25, ≥3.5, ≥4, ≥4.5, ≥5, ≥6 rows	1	\N
2023-05-10	RECOMMENDATION	RxNorm:3638	changed AS ≥4.5 to ≥3.75 and 3.5 to 2.75 duu to changes in the CYP2D6 allele function assignment	1	\N
2022-09-20	RECOMMENDATION	RxNorm:1455099	created	1	\N
2023-04-18	RECOMMENDATION	RxNorm:1455099	changed AS ≥4.5 to 3.75 and AS 3.5 to 2.75 because of the CYP2D6 functionailty assignment changes	1	\N
2023-05-10	TEST_ALERT	RxNorm:7531	changed AS ≥4.5 to ≥3.75 and 3.5 to 2.75 duu to changes in the CYP2D6 allele function assignment	1	\N
2020-07-20	TEST_ALERT	RxNorm:7531	added rows for CYP2D6 AS: ≥6, ≥5, ≥4.5, ≥4, ≥3.5, ≥3.25, ≥3, 4, 3.5, 3, 2.5	1	\N
2023-05-10	TEST_ALERT	RxNorm:2670	added rows for CYP2D6 AS: ≥6, ≥5, ≥3.75, ≥4, ≥3.5, ≥3.25, ≥3, 4, 2.75, 3, 2.5	1	\N
2021-09-08	TEST_ALERT	RxNorm:9071	created	1	\N
2021-10-22	ALLELE_DEFINITION	CYP2D6	added new alleles *146, *147, *149	1	\N
2021-10-22	ALLELE_DEFINITION	CYP2D6	added wobbles (W and M) into *36 due to release of *36.004 which includes amino acid changes that are core allele variants in *49 and *53	1	\N
2021-12-02	ALLELE_DEFINITION	CYP2D6	updated PharmVar ID for *149	1	\N
2022-02-04	ALLELE_DEFINITION	CYP2D6	added *148	1	\N
2022-02-13	ALLELE_DEFINITION	CYP2D6	added 1979C>T to represent updated *20 core allele variants to 1979C>T+1980T>C (L213S) instead of 1980T>C (L213P); this introduces an R at position 1979 for *1 and *124 since some but not all suballeles include the 1979C>T variant	1	\N
2022-02-13	ALLELE_DEFINITION	CYP2D6	updated *20 PharmVar ID	1	\N
2022-04-19	ALLELE_DEFINITION	CYP2D6	protein header at Z3 ('p.Y107I; p.T107N' (in column Z) to 'p.T107N; p.T107I')	1	\N
2022-06-03	ALLELE_DEFINITION	CYP2D6	update of *147 variant single insertion of AAAGGGGCG and PharmVar ID	1	\N
2022-08-14	ALLELE_DEFINITION	CYP2D6	added *152-*163	1	\N
2022-10-28	ALLELE_DEFINITION	CYP2D6	added *150, *151, *164-*171	1	\N
2022-10-28	ALLELE_DEFINITION	CYP2D6	changed PVID for *152 and *153	1	\N
2022-10-28	ALLELE_DEFINITION	CYP2D6	*19: 1662G>C, 2851C>T (R296C), 4181G>C (S486T) set to wobbles S, R, and S due to *19.002 suballele addition to PharmVar	1	\N
2022-12-09	ALLELE_DEFINITION	CYP2D6	added p.E211fs for *150 and p.L231del for *166; PVID for *150 was updated	1	\N
2023-11-13	PAIR	\N	[escitalopram-CYP2D6] PGx Testing: Informative PGx >> none	1	\N
2023-11-13	PAIR	\N	[tacrolimus-CYP3A4] CA Level: 1B >> 2A	1	\N
2023-11-13	PAIR	\N	[atorvastatin-CYP3A4] CA Level: none >> 3	1	\N
2023-11-13	PAIR	\N	[fluvastatin-CYP3A4] CA Level: none >> 3	1	\N
2023-11-13	PAIR	\N	[simvastatin-CYP3A4] CA Level: none >> 3	1	\N
2023-11-13	PAIR	\N	[lovastatin-CYP3A5] CA Level: none >> 3	1	\N
2023-11-13	PAIR	\N	[atorvastatin-CYP3A5] CA Level: none >> 3	1	\N
2023-10-24	PAIR	\N	[terbinafine-CYP2D6] PGx Testing: Informative PGx >> none	1	\N
2023-11-13	PAIR	\N	[simvastatin-CYP3A5] CA Level: none >> 4	1	\N
2020-09-15	PAIR	\N	added PMID for PPI drugs (omeprazole, lansoprazole, dexlansoprazole, pantoprazole, esomeprazole, rabeprazole) rows 43, 42, 45, 109, 260, 313 column G	1	\N
2020-09-15	PAIR	\N	removed links to a CPIC guideline from column C and changed No to n/a for the following rows 99,135,156,172,186,, 217, 230, 235, 237, 238, 243, 244, 245, 268, 319, 321, 323, , 334, 342, 363,364, 365, 375, 377, 378, 407-10, 448, 449, 457, 476-479	1	\N
2020-09-15	PAIR	\N	added URL link for esomeprazole, rabeprazole rows 260, 313 column C	1	\N
2023-10-24	PAIR	\N	[metoprolol-CYP2D6] PGx Testing: Informative PGx >> Actionable PGx	1	\N
2020-09-15	PAIR	\N	changed "used for recommendation" (column H) from n/a to No for rows 260, 313 and from Yes to No for rows 227, 234, 253, 275, 280, 292, 295, 324	1	\N
2020-09-15	PAIR	\N	removed guideline URL and PMID from row 281	1	\N
2020-09-18	PAIR	\N	changed PharmGKB level to 3 for tegafur	1	\N
2020-09-18	PAIR	\N	changed PharmGKB level to 1A for desipramine, imipramine and CYP2D6 and for imipramine, trimipramine, clomipramine, doxepin for CYP2C19	1	\N
2020-10-14	PAIR	\N	updated PharmGKB levels and PGx testing values	1	\N
2021-12-02	PAIR	\N	added ACYP2 and cisplatin at level D	1	\N
2022-04-26	PAIR	\N	[amikacin-MT-RNR1] PharmGKB level changed from 3 to 1A	1	\N
2022-04-26	PAIR	\N	[pimozide-CYP2D6] PharmGKB level changed from 3 to none	1	\N
2022-04-26	PAIR	\N	[tobramycin-MT-RNR1] PharmGKB level changed from 3 to 1A	1	\N
2022-04-26	PAIR	\N	[kanamycin-MT-RNR1] PharmGKB level changed from 3 to 1A	1	\N
2022-12-19	PAIR	\N	updated G6PD pairs	1	\N
2022-12-20	PAIR	\N	updated G6PD/moxifloxacin and statin pairs with no recommendation	1	\N
2023-04-10	PAIR	\N	updated SSRI/SNRI guideline pairs	1	\N
2023-04-11	PAIR	\N	added PMID for SSRI/SNRI guideline	1	\N
2023-10-24	PAIR	\N	[mivacurium-BCHE] PGx Testing: none >> Actionable PGx	1	\N
2023-10-24	PAIR	\N	[lansoprazole-CYP2C19] PGx Testing: Informative PGx >> none	1	\N
2023-10-24	PAIR	\N	[avatrombopag-CYP2C9] PGx Testing: Informative PGx >> none	1	\N
2023-10-24	PAIR	\N	[paroxetine-CYP2D6] PGx Testing: Informative PGx >> none	1	\N
2023-10-24	PAIR	\N	[fluoxetine-CYP2D6] PGx Testing: Informative PGx >> Actionable PGx	1	\N
2023-10-24	PAIR	\N	[quinidine-CYP2D6] PGx Testing: Informative PGx >> none	1	\N
2023-10-24	PAIR	\N	[propafenone-CYP2D6] PGx Testing: Actionable PGx >> Informative PGx	1	\N
2023-10-24	PAIR	\N	[capecitabine-DPYD] PGx Testing: Actionable PGx >> Testing Recommended	1	\N
2023-10-24	PAIR	\N	[tolazamide-G6PD] PGx Testing: none >> Actionable PGx	1	\N
2023-10-24	PAIR	\N	[tolbutamide-G6PD] PGx Testing: none >> Actionable PGx	1	\N
2023-10-24	PAIR	\N	[atorvastatin-LDLR] PGx Testing: Informative PGx >> none	1	\N
2023-10-24	PAIR	\N	[tobramycin-MT-RNR1] PGx Testing: none >> Actionable PGx	1	\N
2023-10-24	PAIR	\N	[amikacin-MT-RNR1] PGx Testing: none >> Actionable PGx	1	\N
2023-10-24	PAIR	\N	[gentamicin-MT-RNR1] PGx Testing: none >> Actionable PGx	1	\N
2023-10-24	PAIR	\N	[plazomicin-MT-RNR1] PGx Testing: none >> Actionable PGx	1	\N
2023-10-24	PAIR	\N	[streptomycin-MT-RNR1] PGx Testing: none >> Actionable PGx	1	\N
2023-10-24	PAIR	\N	[procainamide-NAT2] PGx Testing: Informative PGx >> Actionable PGx	1	\N
2023-10-24	PAIR	\N	[atorvastatin-SLCO1B1] PGx Testing: Informative PGx >> none	1	\N
2023-10-24	PAIR	\N	[simvastatin-SLCO1B1] PGx Testing: Informative PGx >> none	1	\N
2023-10-24	PAIR	\N	[irinotecan-UGT1A1] PGx Testing: Actionable PGx >> Testing Recommended	1	\N
2023-11-13	PAIR	\N	[rosuvastatin-CYP3A5] CA Level: none >> 3	1	\N
2023-11-13	PAIR	\N	[atorvastatin-HMGCR] CA Level: none >> 3	1	\N
2023-04-14	ALLELE_DEFINITION	CYP2D6	change of position for rs72549346 (*42) based on PharmVar update; new PharmVar ID	1	\N
2023-04-20	ALLELE_DEFINITION	CYP2D6	change of position for rs72549346 (*42) based on PharmVar update; new PharmVar ID	1	\N
2023-06-04	ALLELE_DEFINITION	CYP2D6	added *172	1	\N
2023-08-31	ALLELE_DEFINITION	CYP2D6	*57 removed; *57 was re-assigned to CYP2D6*36.005 by PharmVar	1	\N
2023-09-27	ALLELE_DEFINITION	CYP2D6	changed order of content entry in CR table headers	1	\N
2023-10-01	ALLELE_DEFINITION	CYP2D6	change in name convention for hybrid alleles (*13, *61, *63, *68)	1	\N
2023-12-15	ALLELE_DEFINITION	CYP2D6	Modified: protein header 'p.E402L' to 'p.V402L'); NEW POSITION: Position 4125G>C/g.42126667C>G/g.9144G>C/rs1135832; Position 4134T>C/g.42126658A>G/g.9153T>C/rs1135836; Position 4167T>C/g.42126625A>G/g.9186T>C; Position 4170T>C/g.42126622A>G/g.9189T>C/rs747998333; Position 4173C>T/g.42126619G>A/g.9192C>T/rs28371736; Modified: *36 'PVID:PV00460' to 'PVID:PV02379'; *83 'PVID:PV00500' to 'PVID:PV02385'; *141'PVID:PV01593' to 'PVID:PV02389'	1	\N
2024-07-09	ALLELE_DEFINITION	CYP2D6	added *173-*175	1	\N
2024-10-02	ALLELE_DEFINITION	CYP2D6	added *176	1	\N
2024-10-31	ALLELE_DEFINITION	CYP2D6	added *177; updated *150 allele definition (rs16947 was removed from *150.002 suballele but is included in the *150.001 suballele, therefore A at position rs16947 was changed to R)	1	\N
2025-05-01	ALLELE_DEFINITION	CYP2D6	*21 core allele definition changed; added allele *178-*185	1	\N
2025-05-28	ALLELE_DEFINITION	CYP2D6	added rs1135837; rs1555888899; rs566108360; rs150216909; rs993385303; rs538707090; rs774943042; rs1477736084	1	\N
2023-11-13	PAIR	\N	[lovastatin-HMGCR] CA Level: none >> 3	1	\N
2023-11-13	PAIR	\N	[fluvastatin-HMGCR] CA Level: none >> 3	1	\N
2023-11-13	PAIR	\N	[neomycin-MT-RNR1] CA Level: 1A >> 3	1	\N
2024-07-23	PAIR	\N	updated beta blocker pairs for guideline release	1	\N
2024-07-25	PAIR	\N	updated CYP2B6-methadone pair for guideline release	1	\N
2020-07-14	RECOMMENDATION	RxNorm:42355	added AS AS 2.5, 3, 3.5, 4, ≥3, ≥3.25, ≥3.5, ≥4, ≥4.5, ≥5, ≥6 rows	1	\N
2022-09-20	RECOMMENDATION	RxNorm:42355	updated content based on the SSRI-SNRI guideline update	1	\N
2023-04-18	RECOMMENDATION	RxNorm:42355	changed AS ≥4.5 to 3.75 and AS 3.5 to 2.75 because of the CYP2D6 functionailty assignment changes	1	\N
2021-09-08	TEST_ALERT	RxNorm:3108	created	1	\N
2020-07-14	RECOMMENDATION	RxNorm:704	added AS AS 2.5, 3, 3.5, 4, ≥3, ≥3.25, ≥3.5, ≥4, ≥4.5, ≥5, ≥6 rows	1	\N
2023-05-10	RECOMMENDATION	RxNorm:704	changed AS ≥4.5 to ≥3.75 and 3.5 to 2.75 duu to changes in the CYP2D6 allele function assignment	1	\N
2020-08-11	RECOMMENDATION	RxNorm:5489	File created	1	\N
2023-05-10	RECOMMENDATION	RxNorm:5489	changed AS ≥4.5 to ≥3.75 and 3.5 to 2.75 duu to changes in the CYP2D6 allele function assignment	1	\N
2023-05-10	TEST_ALERT	RxNorm:704	changed AS ≥4.5 to ≥3.75 and 3.5 to 2.75 duu to changes in the CYP2D6 allele function assignment	1	\N
2020-07-20	TEST_ALERT	RxNorm:704	added rows for CYP2D6 AS: ≥6, ≥5, ≥4.5, ≥4, ≥3.5, ≥3.25, ≥3, 4, 3.5, 3, 2.5	1	\N
2023-05-10	TEST_ALERT	RxNorm:26225	changed AS ≥4.5 to ≥3.75 and 3.5 to 2.75 duu to changes in the CYP2D6 allele function assignment	1	\N
2020-07-20	TEST_ALERT	RxNorm:26225	added rows for CYP2D6 AS: ≥6, ≥5, ≥4.5, ≥4, ≥3.5, ≥3.25, ≥3, 4, 3.5, 3, 2.5	1	\N
2021-09-08	TEST_ALERT	RxNorm:3445	created	1	\N
2021-09-08	TEST_ALERT	RxNorm:283821	created	1	\N
2016-09-27	ALLELE_DEFINITION	CYP3A5	Added change log tab	1	\N
2019-10-08	ALLELE_DEFINITION	CYP3A5	Updated format, remove function column	1	\N
2020-08-10	ALLELE_DEFINITION	CYP3A5	updated to PharmVar numbering in row 2	1	\N
2020-08-10	ALLELE_DEFINITION	CYP3A5	created second tab for core alleles+overlap (see notes)	1	\N
2010-10-09	ALLELE_DEFINITION	CYP3A5	removed core allele tab	1	\N
2021-09-02	ALLELE_DEFINITION	CYP3A5	based on PharmVar API content replaced for rs41303343 27126_27127insT, p.346fs, g.99652770_99652771insA, g.32228_32229insT, reference cell: del, allele cell: insA to 27126dup p.T346fs, g.99652771dup, g.32228dup, reference cell: A, allele cell: AA	1	\N
2022-02-01	ALLELE_DEFINITION	CYP3A5	*2, *4, *5 retired by PharmVar - removed "wobbles" from *3 at the *2, *4, *5 positions that documented the overlap with *3 suballeles	1	\N
2022-02-01	ALLELE_DEFINITION	CYP3A5	*3.011 retired by PharmVar - removed "wobble" from *3 at the *9 position that documented the overlap with *3.011 allele	1	\N
2022-02-01	ALLELE_DEFINITION	CYP3A5	removed Note: "In addition, variants that present in the core allele for one star allele but also present in some but not allsuballeles of another star allele are included in the other star allele as ambiguous changes using the IUPAC nucleotide code (https://www.bioinformatics.org/sms/iupac.html), e.g. the *3 consensus allele includes a "Y" being either C or T at the 14660A>G position since this variant is part of the *4 core allele but is not part of the *3 core allele at PharmVar since it is not present in all *3 suballeles (only in *3.009). These positions are represented in grey in the Comparative Allele ViewEr (CAVE) tool at PharmVar."	1	\N
2016-05-11	FREQUENCY	CYP2C19	changed *27 annotation for Hu et al from 0 to not tested (sequencing does not include the upstream *27 tag SNP); frequency changes to n/a	1	\N
2016-05-11	FREQUENCY	CYP2C19	corrected ethnicity for Larssen et al (line 333) to Europe	1	\N
2015-08-25	FREQUENCY	CYP2C19	added 8 papers	1	\N
2020-07-17	RECOMMENDATION	RxNorm:343047	Fixed a typo for "interrmediate metabolizer"	1	\N
2020-07-14	RECOMMENDATION	RxNorm:5691	added AS AS 2.5, 3, 3.5, 4, ≥3, ≥3.25, ≥3.5, ≥4, ≥4.5, ≥5, ≥6 rows	1	\N
2023-05-10	RECOMMENDATION	RxNorm:5691	changed AS ≥4.5 to ≥3.75 and 3.5 to 2.75 duu to changes in the CYP2D6 allele function assignment	1	\N
2021-07-30	TEST_ALERT	RxNorm:83367	Deleted possible phenotypes and increased function; updated CDS alerts text to reflect recommendations in 2021 guideline	1	\N
2020-07-15	TEST_ALERT	RxNorm:83367	added row for possible increased function	1	\N
2021-07-30	TEST_ALERT	RxNorm:861634	Deleted possible phenotypes and increased function; updated CDS alerts text to reflect recommendations in 2021 guideline	1	\N
2020-07-15	TEST_ALERT	RxNorm:861634	added row for possible increased function	1	\N
2021-09-08	TEST_ALERT	RxNorm:3639	created	1	\N
2021-09-08	TEST_ALERT	RxNorm:10171	created	1	\N
2022-01-15	FREQUENCY	CYP2C9	Added new alleles *62-75 based on PharmVar update. Allele frequency from gnomAD was also added for alleles that contain single unique variant.	1	\N
2020-10-14	FREQUENCY	CYP2C9	Updated phenotype frequencies to AS frequencies to be consistent with other CYP2C9 information	1	\N
2020-03-24	FREQUENCY	CYP2C9	Updated diplotype and phenotype frequencies	1	\N
2019-08-21	FREQUENCY	CYP2C9	Changed allele frequency averages to weighted averages, altered average, MIN and MAX functions to return a blank cell if selected range is blank	1	\N
2019-08-19	FREQUENCY	CYP2C9	Converted percentage values to decimals	1	\N
2019-07-24	FREQUENCY	CYP2C9	Added new * allele, updated references and updated text descriptions to reflect use of biogeographical groups	1	\N
2018-07-06	FREQUENCY	CYP2C9	Added new references and * alleles, edited allele frequency and reference sheets to be consistent with new PharmGKB biogeographical groups.	1	\N
2017-02-21	FREQUENCY	CYP2C9	updated footnotes	1	\N
2017-02-13	FREQUENCY	CYP2C9	updated footnotes	1	\N
2016-11-08	FREQUENCY	CYP2C9	Link added for CYP2C9 Allele definition Table on Allele frequency by race tab	1	\N
2016-11-04	FREQUENCY	CYP2C9	St Jude added tabs for Diplotype frequency by race, Phenotype frequency by race, Methods	1	\N
2016-09-08	FREQUENCY	CYP2C9	PharmGKB created version 1	1	\N
2022-03-11	FREQUENCY	CYP2C9	fixed diplotpye/phenotype calculations and made layouts consistent	1	\N
2020-07-14	RECOMMENDATION	RxNorm:38400	added AS AS 2.5, 3, 3.5, 4, ≥3, ≥3.25, ≥3.5, ≥4, ≥4.5, ≥5, ≥6 rows	1	\N
2021-01-31	RECOMMENDATION	RxNorm:38400	AS >=3.25 corrected phenotype from NM to UM in pediatrics	1	\N
2021-01-31	RECOMMENDATION	RxNorm:38400	changed text for NM and IM AS 1 from "Initiate with a dose of 0.5 mg/kg and increase to 1.2 mg/kg/day after 3 days." to "Initiate with a dose of 0.5 mg/kg/day and increase to 1.2 mg/kg/day after 3 days." to have 0.5mg/kg/day	1	\N
2023-05-10	RECOMMENDATION	RxNorm:38400	changed AS ≥4.5 to ≥3.75 and 3.5 to 2.75 duu to changes in the CYP2D6 allele function assignment	1	\N
2024-03-20	RECOMMENDATION	RxNorm:103	Updated for the following phenotypes: TPMT Intermediate Metabolizer/NUDT15 Intermediate Metabolizer, TPMT Intermediate Metabolizer/Possible NUDT15 Intermediate Metabolizer, Possible TPMT Intermediate Metabolizer/NUDT15 Intermediate Metabolizer, Possible TPMT Intermediate Metabolizer/Possible NUDT15 Intermediate Metabolizer	1	\N
2020-07-14	RECOMMENDATION	RxNorm:103	log created	1	\N
2023-08-01	TEST_ALERT	RxNorm:2556	fixed typo	1	\N
2021-07-30	TEST_ALERT	RxNorm:42463	Deleted possible phenotypes and increased function; updated CDS alerts text to reflect recommendations in 2021 guideline	1	\N
2020-07-15	TEST_ALERT	RxNorm:42463	added row for possible increased function	1	\N
2021-09-08	TEST_ALERT	RxNorm:4601	created	1	\N
2021-09-08	TEST_ALERT	RxNorm:10178	created	1	\N
\.


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