Methods:
The DPYD frequency table was created using data from ExAC (http://exac.broadinstitute.org/) and the 1000 Genomes project (http://www.ensembl.org/Homo_sapiens/Info/Index).
The average allele frequencies by race were calculated by taking the number with the variant in all studies divided by the total number of individuals tested for the variant in all studies.
All nucleotide changes are according to reference sequence NM_000110.3 and all protein changes are according to reference sequence NP_000101.2
Caveats
If 1000 Genomes and/or ExAC did not return any frequency data for a given variant, cells were left blank

Biogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details can be found at https://www.pharmgkb.org/page/biogeographicalGroups. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.







