-- Data for Name: file_note; Type: TABLE DATA; Schema: cpic; Owner: -
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COPY cpic.file_note (type, entityid, note, ordinal, version) FROM stdin;
GENE_CDS	ABCG2	The phenotype is used to store an interpretation of the test result. This is a design decision that may differ among sites.	0	1
GENE_CDS	ABCG2	For this example, a priority result is defined as a genetic test result that results in a change in drug, drug dose, or drug monitoring.	1	1
GENE_CDS	ABCG2	The specific wording of the interpretive text may differ among sites.	2	1
GENE_CDS	SLCO1B1	The phenotype is used to store an interpretation of the test result. This is a design decision that may differ among sites.	0	1
GENE_CDS	SLCO1B1	For this example, a priority result is defined as a genetic test result that results in a change in drug, drug dose, or drug monitoring.	1	1
GENE_CDS	SLCO1B1	The specific wording of the interpretive text may differ among sites.	2	1
FREQUENCY	MT-RNR1	For full references see "References" tab.	0	1
FREQUENCY	MT-RNR1	aAverage frequencies based on the reported frequencies in one or multiple studies.	1	1
FREQUENCY	MT-RNR1	bBased on the PharmGKB biogeographical groups https://www.pharmgkb.org/page/biogeographicalGroups	2	1
TEST_ALERT	RxNorm:32968	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:32968	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:6026	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:6026	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:42463	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:42463	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:641	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:641	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:3445	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:3445	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:3445	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:3445	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:41493	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:41493	Pharmacist, pharmacologist, or a clinician with pharmacogenetic expertise/training.	1	1
TEST_ALERT	RxNorm:2049549	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:2049549	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:10485	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:10485	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
GENE_CDS	CACNA1S	The phenotype is used to store an interpretation of the test result. This is a design decision that may differ among sites.	0	1
GENE_CDS	CACNA1S	For this example, a priority result is defined as a genetic test result that results in a change in drug, drug dose, or drug monitoring.	1	1
GENE_CDS	CACNA1S	The specific wording of the interpretive text may differ among sites.	2	1
GENE_CDS	TPMT	The phenotype is used to store an interpretation of the test result. This is a design decision that may differ among sites.	0	1
GENE_CDS	TPMT	For this example, a priority result is defined as a genetic test result that results in a change in drug, drug dose, or drug monitoring.	1	1
GENE_CDS	TPMT	The specific wording of the interpretive text may differ among sites.	2	1
FREQUENCY	NUDT15	For full references see "References" tab.	0	1
FREQUENCY	NUDT15	Average frequencies based on the reported frequencies in one or multiple studies.	1	1
FREQUENCY	NUDT15	Based on the PharmGKB biogeographical groups https://www.pharmgkb.org/page/biogeographicalGroups	2	1
FREQUENCY	NUDT15	See allele definition table (https://www.pharmgkb.org/page/nudt15RefMaterials) for allele definitions	3	1
FREQUENCY	NUDT15	Because NUDT15*1 is not genotyped directly, all alleles that are negative for a sequence variation are defaulted to a NUDT15*1 assignment. The inferred frequency for NUDT15*1 is calculated as: 1 - (sum of averaged variant allele frequencies).	4	1
TEST_ALERT	RxNorm:27340	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:27340	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:17128	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:17128	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:17128	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:17128	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:301542	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:301542	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:7833	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:7833	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:7833	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:7833	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:3639	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:3639	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:3639	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:3639	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:103	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:103	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:8687	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:8687	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:8687	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:8687	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:10627	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:10627	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
GENE_CDS	CYP2B6	The phenotype is used to store an interpretation of the test result. This is a design decision that may differ among sites.	0	1
GENE_CDS	CYP2B6	For this example, a priority result is defined as a genetic test result that results in a change in drug, drug dose, or drug monitoring.	1	1
GENE_CDS	CYP2B6	The specific wording of the interpretive text may differ among sites.	2	1
GENE_CDS	CYP2B6	Although two CYP2B6 alleles, *4 and *22, are categorized as increased function alleles, the effect of *4 and *22 on CYP2B6 function with respect to efavirenz plasma exposure appears to be modest based on current evidence. However, the phenotype categories of CYP2B6 rapid metabolizer (RM; one normal function allele and one increased function allele) and CYP2B6 ultra-rapid metabolizer (UM; two increased function alleles) were created to allow for the possibility that these may be clinically relevant for CYP2B6 substrates other than efavirenz. As there is no recommendation for altering dosing for CYP2B6 RMs or UMs for efavirenz, the EHR priority is sent to "normal" for these metabolizers.	3	1
GENE_CDS	UGT1A1	The phenotype is used to store an interpretation of the test result. This is a design decision that may differ among sites.	0	1
GENE_CDS	UGT1A1	For this example, a priority result is defined as a genetic test result that results in a change in drug, drug dose, or drug monitoring.	1	1
GENE_CDS	UGT1A1	The specific wording of the interpretive text may differ among sites.	2	1
FREQUENCY	RYR1	For full references see "References" tab.	0	1
TEST_ALERT	RxNorm:3247	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:3247	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:6472	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:6472	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:36437	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:36437	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:1191	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:1191	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:1191	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:1191	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:4492	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:4492	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:6878	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:6878	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:9071	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:9071	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:9071	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:9071	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:10635	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:10635	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:10635	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:10635	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
GENE_CDS	CYP2C19	The phenotype is used to store an interpretation of the test result. This is a design decision that may differ among sites.	0	1
GENE_CDS	CYP2C19	For this example, a priority result is defined as a genetic test result that results in a change in drug, drug dose, or drug monitoring.	1	1
GENE_CDS	CYP2C19	The specific wording of the interpretive text may differ among sites.	2	1
FREQUENCY	CACNA1S	For full references see "References" tab.	0	1
FREQUENCY	SLCO1B1	For full references see "References" tab.	0	1
FREQUENCY	SLCO1B1	Average frequencies based on the reported frequencies in one or multiple studies.	1	1
FREQUENCY	SLCO1B1	Based on the PharmGKB biogeographical groups https://www.pharmgkb.org/page/biogeographicalGroups	2	1
FREQUENCY	SLCO1B1	See allele definition table (https://www.pharmgkb.org/page/slco1b1RefMaterials) for allele definitions	3	1
FREQUENCY	SLCO1B1	Because SLCO1B1*1 is not genotyped directly, all alleles that are negative for a sequence variation are defaulted to a SLCO1B!*1 assignment. The inferred frequency for SLCO1B1*1 is calculated as: 1 - (sum of averaged variant allele frequencies).	4	1
TEST_ALERT	RxNorm:816346	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:816346	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:816346	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:816346	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:6857	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:6857	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:36453	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:36453	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:38400	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:38400	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:38400	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:38400	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:4502	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:4502	Pharmacist, pharmacologist, or a clinician with pharmacogenetic expertise/training.	1	1
TEST_ALERT	RxNorm:6918	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:6918	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:283821	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:283821	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:10638	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:10638	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
GENE_CDS	CYP2C9	The phenotype is used to store an interpretation of the test result. This is a design decision that may differ among sites. Assignment of all Genotype/Phenotype Summaries based on diplotype is available on the 'Possible CYP2C19' Diplotype tab.	0	1
GENE_CDS	CYP2C9	A priority result is defined as a genetic test result that results in a change in drug, drug dose, or drug monitoring.	1	1
GENE_CDS	CYP2C9	The specific wording of the interpretive text may differ among sites.	2	1
FREQUENCY	CYP2B6	For full references see "references" tab.	0	1
FREQUENCY	CYP2B6	Average frequencies based on the reported frequencies in one or multiple studies.	1	1
FREQUENCY	CYP2B6	Based on the PharmGKB biogeographical groups https://www.pharmgkb.org/page/biogeographicalGroups	2	1
FREQUENCY	CYP2B6	See allele definition table (https://www.pharmgkb.org/page/cyp2b6RefMaterials) for allele definitions	3	1
FREQUENCY	CYP2B6	Because CYP2B6*1 is not genotyped directly, all alleles that are negative for a sequence variation are defaulted to a CYP2B6*1 assignment. The inferred frequency for CYP2B6*1 is calculated as: 1 - (sum of averaged variant allele frequencies).	4	1
FREQUENCY	TPMT	For full references see "References" tab.	0	1
FREQUENCY	TPMT	Average frequencies based on the reported frequencies in one or multiple studies.	1	1
FREQUENCY	TPMT	Based on the PharmGKB biogeographical groups https://www.pharmgkb.org/page/biogeographicalGroups	2	1
FREQUENCY	TPMT	See the Allele Definition Tables at https://www.pharmgkb.org/page/tpmtRefMaterials for allele definitions	3	1
FREQUENCY	TPMT	Because TPMT*1 is not genotyped directly, all alleles that are negative for a sequence variation are defaulted to a TPMT*1 assignment. The inferred frequency for TPMT*1 is calculated as: 1 - (sum of averaged variant allele frequencies).	4	1
TEST_ALERT	RxNorm:3638	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:3638	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:7531	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:7531	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:36567	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:36567	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:1256	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:1256	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:4601	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:4601	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:4601	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:4601	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:7240	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:7240	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:7240	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:7240	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:NA	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:NA	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:10689	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:10689	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
GENE_CDS	CYP3A5	The coded diplotype/phenotype summary is used to store an interpretation of the test result. This is a design decision that may differ among sites. Assignment of all Genotype/Phenotype Summaries based on diplotype is available on the 'Possible CYP2C19' Diplotype tab.	0	1
GENE_CDS	CYP3A5	For this example, a priority result is defined as a genetic test result that results in a change in drug, drug dose, or drug monitoring.	1	1
GENE_CDS	CYP3A5	The specific wording of the interpretive text may differ among sites.	2	1
FREQUENCY	CYP2C9	For full references see "References" tab.	0	1
FREQUENCY	CYP2C9	Average frequencies based on the reported frequencies in one or multiple studies.	1	1
FREQUENCY	CYP2C9	Based on the PharmGKB biogeographical groups https://www.pharmgkb.org/page/biogeographicalGroups	2	1
FREQUENCY	CYP2C9	See allele definition table (https://www.pharmgkb.org/page/cyp2c9RefMaterials) for allele definitions	3	1
FREQUENCY	CYP2C9	Because CYP2C9*1 is not genotyped directly, all alleles that are negative for a sequence variation are defaulted to a CYP2C9*1 assignment. The inferred frequency for CYP2C9*1 is calculated as: 1 - (sum of averaged variant allele frequencies).	4	1
FREQUENCY	UGT1A1	For full references see "References" tab.	0	1
FREQUENCY	UGT1A1	Average frequencies are based on the actual number of subjects with each allele as reported in one or multiple studies.	1	1
FREQUENCY	UGT1A1	Based on the PharmGKB biogeographical groups https://www.pharmgkb.org/page/biogeographicalGroups	2	1
FREQUENCY	UGT1A1	See allele definition table (https://www.pharmgkb.org/page/ugt1a1RefMaterials) for allele definitions	3	1
FREQUENCY	UGT1A1	Because UGT1A1*1 is not genotyped directly, all alleles that are negative for a sequence variation are defaulted to a UGT1A1*1 assignment. The inferred frequency for UGT1A1*1 is calculated as: 1 - (sum of averaged variant allele frequencies).	4	1
TEST_ALERT	RxNorm:195085	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:195085	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:7646	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:7646	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:7646	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:7646	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:10154	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:10154	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:194000	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:194000	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	ATC:D06AX07	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	ATC:D06AX07	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:7299	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:7299	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:10109	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:10109	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:27392	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:27392	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
GENE_CDS	DPYD	The phenotype is used to store an interpretation of the test result. This is a design decision that may differ among sites.	0	1
GENE_CDS	DPYD	For this example, a priority result is defined as a genetic test result that results in a change in drug, drug dose, or drug monitoring.	1	1
GENE_CDS	DPYD	The specific wording of the interpretive text may differ among sites.	2	1
FREQUENCY	CYP2D6	In the Sub-Saharan African group, presented data for Twesigomwe et al., 2022 PMID 36111505 is a combination of frequencies from PMID 36111505 and Wang et al. 2022 PMID 36294714. See the Methods and Caveats tab for how *1 frequencies are determined for this file.	0	1
FREQUENCY	VKORC1	For full references see "References" tab.	0	1
FREQUENCY	VKORC1	Average frequencies based on the reported frequencies in one or multiple studies.	1	1
FREQUENCY	VKORC1	Based on the PharmGKB biogeographical groups https://www.pharmgkb.org/page/biogeographicalGroups	2	1
TEST_ALERT	RxNorm:3920	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:3920	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:26225	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:26225	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:42316	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:42316	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:140587	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:140587	Pharmacist, pharmacologist, or a clinician with pharmacogenetic expertise/training.	1	1
TEST_ALERT	RxNorm:4815	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:4815	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:4815	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:4815	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:7337	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:7337	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:10171	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:10171	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:10171	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:10171	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:39786	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:39786	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
DIPLOTYPE_PHENOTYPE	RYR1	The CPIC guideline includes RYR1 variants assigned a Allele Clinical Functional Status of Normal function, Uncertain function, and Malignant Hyperthermia associated (see the "RYR1_allele_functionality_reference" file). A translation of Allele Function combinations to Phenotype is available in the "RYR1_phenotypes" file. It might be possible that a subject could have more than 2 RYR1 variants and this RYR1_Diplotype_Phenotype_Table is a representation of possible RYR1 genotypes considering the two functionally most impacted RYR1 variants.	0	1
GENE_CDS	G6PD	For this example, a priority result is defined as a genetic test result that results in a change in drug, drug dose, or drug monitoring.	0	1
GENE_CDS	G6PD	The specific wording of the interpretive text may differ among sites.	1	1
FREQUENCY	CYP3A5	For full references see "References" tab.	0	1
FREQUENCY	CYP3A5	Average frequencies based on the reported frequencies in one or multiple studies.	1	1
FREQUENCY	CYP3A5	Based on the PharmGKB biogeographical groups https://www.pharmgkb.org/page/biogeographicalGroups	2	1
FREQUENCY	CYP3A5	See the Allele Definition Table at http://www.pharmgkb.org/cyp3a5RefMaterials for allele definitions	3	1
FREQUENCY	CYP3A5	Because CYP3A5*1 is not genotyped directly, all alleles that are negative for a sequence variation are defaulted to a CYP3A5*1 assignment. The inferred frequency for CYP3A5*1 is calculated as: 1 - (sum of averaged variant allele frequencies).	4	1
TEST_ALERT	RxNorm:704	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:704	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:321988	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:321988	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:32624	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:32624	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:10324	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:10324	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:2348	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:2348	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:2348	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:2348	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:5489	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:5489	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:7454	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:7454	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:10178	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:10178	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:10178	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:10178	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:1151	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:1151	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:1151	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:1151	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
GENE_CDS	HLA-A	The phenotype is used to store an interpretation of the test result. This is a design decision that may differ among sites.	0	1
GENE_CDS	HLA-A	For this example, a priority result is defined as a genetic test result that results in a change in drug, drug dose, or drug monitoring.	1	1
GENE_CDS	HLA-A	The specific wording of the interpretive text may differ among sites.	2	1
FREQUENCY	CYP4F2	For full references see "references" tab.	0	1
FREQUENCY	CYP4F2	Average frequencies based on the reported frequencies in one or multiple studies.	1	1
FREQUENCY	CYP4F2	Based on the PharmGKB biogeographical groups https://www.pharmgkb.org/page/biogeographicalGroups	2	1
FREQUENCY	CYP4F2	See allele definition table (https://www.pharmgkb.org/page/cyp4f2RefMaterials) for allele definitions	3	1
FREQUENCY	CYP4F2	Because CYP4F2*1 is not genotyped directly, all alleles that are negative for a sequence variation are defaulted to a CYP4F2*1 assignment. The inferred frequency for CYP4F2*1 is calculated as: 1 - (sum of averaged variant allele frequencies).	4	1
TEST_ALERT	RxNorm:343047	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:343047	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:41127	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:41127	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:40790	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:40790	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:40790	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:40790	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:37790	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:37790	Pharmacist, pharmacologist, or a clinician with pharmacogenetic expertise/training.	1	1
TEST_ALERT	RxNorm:2393	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:2393	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:2393	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:2393	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:5521	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:5521	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:5521	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:5521	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:7517	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:7517	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:7517	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:7517	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:10831	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:10831	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:10831	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:10831	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:11258	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:11258	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:11258	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:11258	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
GENE_CDS	HLA-B	The phenotype is used to store an interpretation of the test result. This is a design decision that may differ among sites.	0	1
GENE_CDS	HLA-B	For this example, a priority result is defined as a genetic test result that results in a change in drug, drug dose, or drug monitoring.	1	1
GENE_CDS	HLA-B	The specific wording of the interpretive text may differ among sites.	2	1
FREQUENCY	DPYD	Both variants in c.1129-5923C>G, c.1236G>A (HapB3) are listed with identical frequencies in 1000 Genomes	0	1
FREQUENCY	DPYD	For full references see "References" tab.	1	1
FREQUENCY	DPYD	Average frequencies based on the reported frequencies in one or multiple studies.	2	1
FREQUENCY	DPYD	Based on the PharmGKB biogeographical groups https://www.pharmgkb.org/page/biogeographicalGroups	3	1
FREQUENCY	DPYD	See allele definition table (https://www.pharmgkb.org/page/dpydRefMaterials) for allele definitions	4	1
TEST_ALERT	RxNorm:83367	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:83367	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:42355	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:42355	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:32937	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:32937	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:10834	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:10834	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:2551	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:2551	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:2551	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:2551	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:5640	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:5640	Pharmacist, pharmacologist, or a clinician with pharmacogenetic expertise/training.	1	1
TEST_ALERT	RxNorm:7623	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:7623	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:7623	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:7623	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:10184	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:10184	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:10184	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:10184	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:1455099	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:1455099	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
GENE_CDS	MT-RNR1	The phenotype is used to store an interpretation of the test result. This is a design decision that may differ among sites.	0	1
GENE_CDS	MT-RNR1	For this example, a priority result is defined as a genetic test result that results in a change in drug, drug dose, or drug monitoring.	1	1
GENE_CDS	MT-RNR1	The specific wording of the interpretive text may differ among sites.	2	1
FREQUENCY	G6PD	The allele frequency table was made by searching the gnomAD database v2.1.1 except for Cairo from v3.1.2	0	1
FREQUENCY	G6PD	Based on the PharmGKB biogeographical groups https://www.pharmgkb.org/page/biogeographicalGroups	1	1
FREQUENCY	G6PD	See allele definition table (https://www.pharmgkb.org/page/g6pdRefMaterials) for allele definitions	2	1
FREQUENCY	G6PD	Because B(reference) is not genotyped directly, all alleles that are negative for a sequence variation are defaulted to a B (reference) assignment. The inferred frequency for B(reference) is calculated as: 1 - (sum of averaged variant allele frequencies) but this may not be accurate since there are many variants with no known frequency.	3	1
FREQUENCY	G6PD	Note that gnomAD does not calculate haploytpe frequencies. Some haplotypes have frequencies in this spreadsheet if a unique allele in the haplotype has frequency information in gnomAD AND if the other variant in the haplotype is known to have normal function	4	1
FREQUENCY	G6PD	Note that some variants in this spreadsheet can either be found alone or in a haplotype (in combination with other variants). Therefore the frequency reported MAY NOT BE FOR THE VARIANT ALONE, BUT ALSO FOR THE VARIANT IF FOUND IN A HAPLOTYPE.	5	1
TEST_ALERT	RxNorm:2002	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:2002	"Clinical Pharmacist" could be a pharmacist, pharmacologist, or a clinician with pharmacogenetic expertise/training.	1	1
TEST_ALERT	RxNorm:72236	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:72236	Pharmacist, pharmacologist, or a clinician with pharmacogenetic expertise/training.	1	1
TEST_ALERT	RxNorm:8183	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:8183	Pharmacist, pharmacologist, or a clinician with pharmacogenetic expertise/training.	1	1
TEST_ALERT	RxNorm:121243	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:121243	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:121243	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:121243	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:2670	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:2670	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:6099	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:6099	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:7934	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:7934	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:9524	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:9524	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:9524	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:9524	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
GENE_CDS	NUDT15	The phenotype is used to store an interpretation of the test result. This is a design decision that may differ among sites.	0	1
GENE_CDS	NUDT15	For this example, a priority result is defined as a genetic test result that results in a change in drug, drug dose, or drug monitoring.	1	1
GENE_CDS	NUDT15	The specific wording of the interpretive text may differ among sites.	2	1
FREQUENCY	HLA-A	For full references see "References" tab.	0	1
FREQUENCY	HLA-A	Average frequencies based on the reported frequencies in one or multiple studies.	1	1
FREQUENCY	HLA-A	Based on the PharmGKB biogeographical groups https://www.pharmgkb.org/page/biogeographicalGroups	2	1
TEST_ALERT	RxNorm:2556	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:2556	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:5095	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:5095	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:8356	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:8356	Pharmacist, pharmacologist, or a clinician with pharmacogenetic expertise/training.	1	1
TEST_ALERT	RxNorm:190521	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:190521	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:3108	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:3108	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:20890	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:20890	Pharmacist, pharmacologist, or a clinician with pharmacogenetic expertise/training.	1	1
TEST_ALERT	RxNorm:1011650	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:1011650	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:10207	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:10207	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
DIPLOTYPE_PHENOTYPE	DPYD	It is possible that a subject has > 2 DPYD variants and this DPYD_Diplotype_Phenotype_Table is a representation of possible DPYD genotypes considering the two functionally most impacted (lowest activity value) variants. Based on the CPIC guideline for Dihydropyrimidine Dehydrogenase Genotype and Fluoropyrimidine Dosing: 2017 Update (PMID: 29152729), the DPD phenotype is assigned using a gene activity score (DPYD-AS; based on the DPYD Allele Functionality Table), calculated as the sum of the two DPYD variants with the lowest variant activity value. A translation of Allele Function combinations to Phenotype is available in the "DPYD_phenotypes" file. If two decreased/no function variants are present, each decreased/no function variant is considered to be on a different gene copy when the phase is not known.	0	1
ALLELE_DEFINITION	CACNA1S	Variant selection based on the CPIC guideline for potent volatile anesthetic agents and succinylcholine and RYR1 and CACNA1S.	0	1
ALLELE_DEFINITION	CFTR	rsID=RefSNP accession ID number (http://www.ncbi.nlm.nih.gov/snp/)	0	1
ALLELE_DEFINITION	CFTR	All variants are annotated to the positive chromosomal strand.	1	1
ALLELE_DEFINITION	CFTR	Class is defined in PMID: 20932301.	2	1
ALLELE_DEFINITION	CFTR	Table includes variants listed as ivacaftor responsive on FDA-approved ivacaftor (Kalydeco) label (see change log for updates); indicated based on clinical data	3	1
ALLELE_DEFINITION	CYP2B6	rsID=RefSNP accession ID number (http://www.ncbi.nlm.nih.gov/snp/)	0	1
ALLELE_DEFINITION	CYP2B6	All variants are annotated to the positive chromosomal strand.	1	1
ALLELE_DEFINITION	CYP2B6	See PharmVar website (http://www.pharmvar.org) for comprehensive haplotype definitions of CYP2B6 variant alleles and updated allele information.	2	1
ALLELE_DEFINITION	CYP2B6	An important caveat for all genotyping tests is that the decision to assign an allele a "wild-type" status is based upon a genotyping test that interrogates only the most common and already-proven sites of functional variation. In human DNA, it is always possible that a new, previously undiscovered (and therefore un-interrogated) site of variation may confer loss-of-function in an individual, and thus lead to the rare possibility of a non-functional allele being erroneously called as "wild-type."	3	1
ALLELE_DEFINITION	CYP2C19	The variants included in the alleles are based on the PharmVar core alleles (for core allele definitions only, see https://www.pharmvar.org/gene/CYP2C19). In addition, variants that present in the core allele for one star allele but also present in some but not allsuballeles of another star allele are included in the other star allele as ambiguous changes using the IUPAC nucleotide code (https://www.bioinformatics.org/sms/iupac.html), e.g. the *4 consensus allele includes a "Y" being either C or T at the -806C>T position since this variant is part of the *17 core allele but is not part of the *4 core allele at PharmVar since it is not present in all *4 suballeles. These postions are represented in grey in the Comparative Allele ViewEr (CAVE) tool at PharmVar.	0	1
ALLELE_DEFINITION	CYP2C19	PharmVAR releases new alleles based on received submissions, see https://www.pharmvar.org for comprehensive haplotype definitions of CYP2C19 variant alleles, including sub-alleles, and updated allele information.	1	1
ALLELE_DEFINITION	CYP2C19	rsID=RefSNP accession ID number (http://www.ncbi.nlm.nih.gov/snp/)	2	1
TEST_ALERT	RxNorm:10207	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:10207	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
ALLELE_DEFINITION	CYP2C19	All variants are annotated to the positive DNA strand.	3	1
ALLELE_DEFINITION	CYP2C19	An important caveat for all genotyping tests is that the decision to assign an allele a wild-type status is based upon a genotyping test that interrogates only the most common and already- proven sites of functional variation. It is always possible that a novel, previously undiscovered (and therefore un-interrogated) site of variation may confer loss-of-function in an individual, and thus lead to the rare possibility of a non-functional allele being erroneously called as wild-type.	4	1
ALLELE_DEFINITION	CYP2C19	The deterimental CYP2C19*4-defining SNP (rs28399504) has been identified to be linked (i.e. on the same chromosome) with *17 (-806C>T; rs12248560) in certain ethnic subpopulations. To distinguish the *4 (no function) and *17 (increased function) alleles, both rs28399504 and rs12248560 needs to be genotyped [PMID: 21358751, PMID: 24012947]). This haplotype is designated CYP2C19*4B [PMID: 21716271, PMID: 21358751].	5	1
ALLELE_DEFINITION	CYP2C19	The SNP c.463G>T (rs374036992) has been identified to occur in linkage with the *17-defining SNP (- 806C>T; rs12248560). To distinguish *17 from this haplotype, c.463G>T needs to be genotyped [PMID: 25141895]. This allele has not been submitted to PharmVar for a star allele designation.	6	1
ALLELE_DEFINITION	CYP2C19	CYP2C19*27 was reassigned to CYP2C19*1.006 with PharmVar Version 4.0 Last Updated May 7 2019	7	1
ALLELE_DEFINITION	CYP2C19	CYP2C19*36 is a full gene deletion and *37 is a partial gene deletion that includes at least exon 1; for details see the PharmVar CYP2C19 GeneFocus (PMID 32602114) and the CYP2C19 Structural Variation document at https://www.pharmvar.org/gene/CYP2C19).	8	1
ALLELE_DEFINITION	CYP2C19	CYP2C19*38 was set as reference allele as this allele matches the human genome CYP2C19 Reference sequence LRG_584 / NG_008384.3. The RefSeq (LRG_584 / NG_008384.3) has 80161A while many of star alleles, including all *1 suballeles have 80161G. Thus, the CYP2C19*1 core allele is defined by one amino acid (I331V), while the *38 core allele definition does not have any amino acid changes.	9	1
ALLELE_DEFINITION	CYP2C9	PharmVAR releases new alleles based on received submissions, see https://www.pharmvar.org for comprehensive haplotype definitions of CYP2C9 variant alleles, including sub-alleles, and updated allele information.	0	1
ALLELE_DEFINITION	CYP2C9	rsID=RefSNP accession ID number (http://www.ncbi.nlm.nih.gov/snp/)	1	1
ALLELE_DEFINITION	CYP2C9	All variants are annotated to the positive DNA strand.	2	1
ALLELE_DEFINITION	CYP2C9	An important caveat for all genotyping tests is that the decision to assign an allele a "wild-type" status is based upon a genotyping test that interrogates only the most common and already-proven sites of functional variation. In human DNA, it is always possible that a new, previously undiscovered (and therefore un-interrogated) site of variation may confer loss-of-function in an individual, and thus lead to the rare possibility of a non-functional allele being erroneously called as "wild-type."	3	1
ALLELE_DEFINITION	CYP2C9	Citations for assignment of function can be found at https://www.pharmgkb.org/page/cyp2c9RefMaterials	4	1
ALLELE_DEFINITION	CYP2C9	Content is accessed through the PharmVar API. HGVS and 'PharmVar-style' (accessible on the PharmVar website) positions may differ for indels in some instances which is most likely explained by differences in sequence alignments. Also, PharmVar displays single nucleotide insertions as 'ins' while the HGVS display is as duplications or 'dub' if the insertion is the same base as the prior base.	5	1
ALLELE_DEFINITION	CYP2D6	The variants included in the alleles are based on the PharmVar core alleles (for core allele definitions only, see https://www.pharmvar.org/gene/CYP2D6). In addition, variants that present in the core allele for one star allele but also present in some but not all suballeles of another star allele are included in the other star allele as ambiguous changes using the IUPAC nucleotide code (https://www.bioinformatics.org/sms/iupac.html), e.g. the *4 consensus allele includes a "R" being either G or A (positive strand) at the 100C>T (P34S) position since this variant is part of other core star alleles, e.g. *10, but is not part of the *4 core allele at PharmVar since it is not present in all *4 suballeles. These postions are represented in grey (G) in the Comparative Allele ViewEr (CAVE) tool at PharmVar. The g.42129130C>G position is an exception. The SNP by itself causes a synonymous change, therefore by itself the SNP would not be part of a core allele based on the core allele definition. However, in *29 and *70 the SNP is needed for the amino acid change and therefore part of the *29 and *70 core allele definition in PharmVar. To follow the above, "S" is added at the position for star alleles in which not all suballeles carry the SNP. In case all suballeles have the SNP "G" is added.	0	1
ALLELE_DEFINITION	CYP2D6	At PharmVar, information about duplications and gene hybrids are available through https://www.pharmvar.org/gene-support/Variation_CYP2D6.pdf.	1	1
ALLELE_DEFINITION	CYP2D6	PharmVAR releases new alleles based on received submissions, see https://www.pharmvar.org for comprehensive haplotype definitions of CYP2D6 variant alleles, including sub-alleles, and updated allele information.	2	1
ALLELE_DEFINITION	CYP2D6	Amino acid changes are displayed per single variantion. However, in some alleles the 2 consecutive variants together cause a different amino acid change as each by itself. *29, *70: 1660G>A and 1662G>C result in V136I; *82: 1021A>T and 1022C>A result in T107Y; in exon 9 conversion: 4156C>T and 4157A>T result in H478S, 4168G>A and 4169C>G result in A482S	3	1
ALLELE_DEFINITION	CYP2D6	All variants are annotated to the positive DNA strand	4	1
ALLELE_DEFINITION	CYP2D6	rsID are RefSNP accession ID number (http://www.ncbi.nlm.nih.gov/snp/).	5	1
ALLELE_DEFINITION	CYP2D6	The CYP2D6*1 allele is characterized by the absence of any sequence variations. Consequently, this allele cannot be identified by a SNP; rather CYP2D6*1 is assigned by default when no SNPs are detected during testing.	6	1
ALLELE_DEFINITION	CYP2D6	The CYP2D6*2 allele is typically characterized by two amino acid changes; both, however also occur in many other CYP2D6 alleles. Therefore, if an allele carries these two SNPs exclusively, it is designated CYP2D6*2. Interrogating for additional SNPs is the only way to distinguish CYP2D6*2 from other alleles (e.g., CYP2D6*17 and *41).	7	1
ALLELE_DEFINITION	CYP2D6	4180G>C is present on many allelic variants including functional and non-functional variants. Specifically, it has been found on some CYP2D6*4 subvariants. While some tests include this SNP, it cannot be utilized to identify an allelic variant with certainty.	8	1
ALLELE_FUNCTION_REFERENCE	CYP2B6	CYP2B6 functional metabolic effects may be substrate specific (and extrapolations to other substrates may not be reliable).	0	1
GENE_CDS	RYR1	The phenotype is used to store an interpretation of the test result. This is a design decision that may differ among sites.	0	1
ALLELE_DEFINITION	CYP2D6	An important caveat for all genotyping tests is that the decision to assign an allele a wild-type status is based upon a genotyping test that interrogates only the most common and already- proven sites of functional variation. It is always possible that a novel, previously undiscovered (and therefore un-interrogated) site of variation may confer loss-of-function in an individual, and thus lead to the rare possibility of a non-functional allele being erroneously called as wild-type.	9	1
ALLELE_DEFINITION	CYP2D6	Content is accessed through the PharmVar API. HGVS and 'PharmVar-style' (accessible on the PharmVar website) positions may differ for indels in some instances which is most likely explained by differences in sequence alignments. Also, PharmVar displays single nucleotide insertions as 'ins' while the HGVS display is as duplications or 'dup' if the insertion is the same base as the prior base. The entries in the 'Free Text' field in row 2 reflect the default variant names on the CYP2D6 PharmVar page (https://www.pharmvar.org/gene/CYP2D6). Additional variant coordinates are consistent with the content displayed on the upper section of the 'Variant Positions' window which can be accessed by clicking on the variant of interest on the CYP2D6 PharmVar page.	10	1
ALLELE_DEFINITION	CYP3A5	The variants included are based on the PharmVar core alleles (for core alleles only see https://www.pharmvar.org/gene/CYP3a5).	0	1
ALLELE_DEFINITION	CYP3A5	See PharmVar website (http://www.pharmvar.org) for comprehensive haplotype definitions of CYP3A5 variant alleles, including sub-alleles, and updated allele information.	1	1
ALLELE_DEFINITION	CYP3A5	rsID=RefSNP accession ID number (http://www.ncbi.nlm.nih.gov/snp/)	2	1
ALLELE_DEFINITION	CYP3A5	All variants are annotated to the positive DNA strand.	3	1
ALLELE_DEFINITION	CYP3A5	An important caveat for all genotyping tests is that the decision to assign an allele a "wild- type" status is based upon a genotyping test that interrogates only the most common and already-proven sites of functional variation. In human DNA, it is always possible that a new, previously undiscovered (and therefore un-interrogated) site of variation may confer loss-of- function in an individual, and thus lead to the rare possibility of a non-functional allele being erroneously called as "wild-type"	4	1
ALLELE_DEFINITION	CYP3A5	Citations for assignment of function can be found at https://www.pharmgkb.org/page/cyp3a5RefMaterials	5	1
ALLELE_DEFINITION	CYP3A5	Content is accessed through the PharmVar API. HGVS and 'PharmVar-style' (accessible on the PharmVar website) positions may differ for indels in some instances which is most likely explained by differences in sequence alignments. Also, PharmVar displays single nucleotide insertions as 'ins' while the HGVS display is as duplications or 'dub' if the insertion is the same base as the prior base.	6	1
ALLELE_DEFINITION	CYP4F2	rsID=RefSNP accession ID number (http://www.ncbi.nlm.nih.gov/snp/)	0	1
ALLELE_DEFINITION	CYP4F2	All variants are annotated to the positive DNA strand.	1	1
ALLELE_DEFINITION	CYP4F2	See PharmVar website (http://pharmvar.org) for comprehensive haplotype definitions of CYP4F2 variant alleles and updated allele information.	2	1
ALLELE_DEFINITION	CYP4F2	An important caveat for all genotyping tests is that the decision to assign an allele a "wild-type" status is based upon a genotyping test that interrogates only the most common and already-proven sites of functional variation. In human DNA, it is always possible that a new, previously undiscovered (and therefore un-interrogated) site of variation may confer loss-of-function in an individual, and thus lead to the rare possibility of a non-functional allele being erroneously called as "wild-type."	3	1
ALLELE_DEFINITION	DPYD	Variant selection is based on the CPIC guideline for Fluoropyrimidines and DPYD (https://cpicpgx.org/guidelines/guideline-for-fluoropyrimidines-and-dpyd/) and sourced from PharmVar (https://www.pharmvar.org/gene/DPYD).	0	1
ALLELE_DEFINITION	DPYD	All variants are annotated to the positive DNA strand.	1	1
ALLELE_DEFINITION	DPYD	As an individual only carries a maximum of two fully functional DPYD copies, common normal function variants may be located on the same gene copy as other normal	2	1
ALLELE_DEFINITION	DPYD	c.1129-5923C>G is likely the HapB3 haplotype causal variant. c.1236G>A (E412E) is a proxy SNP for HapB3.	3	1
ALLELE_DEFINITION	DPYD	Individual patients have been reported (PMID 38129972) to carry only one of the two SNPs in the HapB3 haplotype (i.e., c.1236G>A without c.1129-5923C>G), suggesting that the two variants are not in complete linkage disequilibrium. CPIC updated the allele definition to include the c.1129-5923C>G SNP separately as this is likely the causal variant leading to decreased function. CPIC also retained the HapB3 haplotype definition for cases where only the c.1236G>A variant is tested (e.g. whole exome sequencing). While CPIC recommends to directly test the causal SNP if possible, in cases where only c.1236G>A is tested or results are available for, it should be clearly stated in the test report that "decreased function" was inferred by detecting the exonic tag SNP, and disclose that in rare cases, the causal decreased function variant c.1129-5923C>G may not be present despite having this tag SNP.	4	1
ALLELE_DEFINITION	DPYD	c.680+139G>A is not exclusive to HapB3 and therefore not a suitable proxy.	5	1
ALLELE_DEFINITION	DPYD	rsID rs3918290, when combined with rs1801159, makes up DPYD*2B	6	1
ALLELE_DEFINITION	DPYD	rs56293913, rs3790387, rs2811202 are all part of a common haplotype that also encompasses c.496A>G (M166V).	7	1
ALLELE_DEFINITION	DPYD	The rs115632870 variant was found to be in linkage disequilibrium (D'=1) with the decreased function variant rs115232898 (Y186C); the decreased function associated with this variant is likely due to this linkage.	8	1
ALLELE_DEFINITION	DPYD	Content is accessed through the PharmVar API. HGVS and 'PharmVar-style' (accessible on the PharmVar website) positions may differ for indels in some instances which is most likely explained by differences in sequence alignments. Also, PharmVar displays single nucleotide insertions as 'ins' while the HGVS display is as duplications or 'dub' if the insertion is the same base as the prior base.	9	1
ALLELE_DEFINITION	G6PD	This modified table of G6PD variants is from PMID:22293322, https://grenada.lumc.nl/LOVD2/MR/home.php?select_db=G6PD, with several additional variants.	0	1
ALLELE_DEFINITION	G6PD	rsID=RefSNP accession ID number (http://www.ncbi.nlm.nih.gov/snp/)	1	1
ALLELE_DEFINITION	G6PD	All variants are annotated to the positive DNA strand.	2	1
ALLELE_FUNCTION_REFERENCE	CYP2D6	CNV alleles are based on Table 2 'CYP2D6 Identical Gene Duplications/Multiplications' from the PharmVar CYP2D6 structural variation document (https://a.storyblok.com/f/70677/x/d80b535e9c/cyp2d6_structural-variation_v3-2.pdf).	0	1
FREQUENCY	HLA-B	For full references see "References" tab.	0	1
ALLELE_DEFINITION	G6PD	Please note; WHO class as reported in PMID:22293322 and Luzzatto, L. & Poggi, V. Glucose-6-Phosphate Dehydrogenase Deficiency In: Nathan and Oski's Hematology of Infancy and Childhood, 7th Edition (ed. Meloni, D., Anderson, A. Authors of the book: Orkin, S.H., Fisher, D.E., Look, A.T., Lux IV, S.E., Ginsburg, D., Nathan, D.G. ) (Saunders, Elsevier., 2009) or individual references. This class may have been assigned based on just clinical\nmanifestations and not enzyme activity level or characterization of the enzyme variant.	3	1
ALLELE_DEFINITION	G6PD	Likely phenotype as referenced in this guideline, based on converting assigned WHO class to 3 phenotypes. "Normal" defined as very mild or no enzyme deficiency (>60% normal enzyme levels); "Deficient" defined as mild to severely deficient (<10-60% normal) enzyme levels; "Deficient with CNSHA" defined as severe G6PD enzyme deficiency (<10% activity) with chronic non-spherocytic hemolytic anemia based on Luzzatto, L. & Poggi, V. Glucose-6-Phosphate Dehydrogenase Deficiency In: Nathan and Oski's Hematology of Infancy and Childhood, 7th Edition (ed. Meloni, D., Anderson, A. Authors of the book: Orkin, S.H., Fisher, D.E., Look, A.T., Lux IV, S.E., Ginsburg, D., Nathan, D.G. ) (Saunders, Elsevier., 2009).	4	1
ALLELE_DEFINITION	IFNL3	rsID=RefSNP accession ID number (http://www.ncbi.nlm.nih.gov/snp/)	0	1
ALLELE_DEFINITION	IFNL3	All variants are annotated to the positive DNA strand.	1	1
ALLELE_DEFINITION	MT-RNR1	Variant selection based on the CPIC guideline for aminoglycoside antibiotics and MT-RNR1.	0	1
ALLELE_DEFINITION	NUDT15	PharmVAR releases new alleles based on received submissions, see https://www.pharmvar.org/gene/NUDT15 for comprehensive haplotype definitions of NUDT15 variant alleles, including sub-alleles, and updated allele information.	0	1
ALLELE_DEFINITION	NUDT15	rsID=RefSNP accession ID number (http://www.ncbi.nlm.nih.gov/snp/)	1	1
ALLELE_DEFINITION	NUDT15	All variants are annotated to the positive DNA strand.	2	1
ALLELE_DEFINITION	NUDT15	rs554405994 was merged into rs869320766 which was merged into rs746071566	3	1
ALLELE_DEFINITION	NUDT15	Content is accessed through the PharmVar API. HGVS and 'PharmVar-style' (accessible on the PharmVar website) positions may differ for indels in some instances which is most likely explained by differences in sequence alignments. Also, PharmVar displays single nucleotide insertions as 'ins' while the HGVS display is as duplications or 'dub' if the insertion is the same base as the prior base.	4	1
ALLELE_DEFINITION	RYR1	Variant selection based on an update of the CPIC guideline for potent volatile anesthetic agents and succinylcholine. The guideline update includes the published list of RYR1 variants (supplemental table S2), which are evaluated by the ClinGen malignant hyperthermia susceptibility (MHS) variant curation expert panel and classified for RYR1-related malignant hyperthermia susceptibility based on specified the ACMG/AMP criteria (PMID 35849058).	0	1
ALLELE_DEFINITION	RYR1	The deletion of an E can be represented as E2347del orE2348del (c.7039_7041delGAG or c.7042_7044delGAG, respectivly). c.7042_7044delGAG is used to name the variant in the file to reflect the ClinGen naming, however the mapping of the variant is done according to the corresponding rsID rs121918596.	1	1
ALLELE_DEFINITION	SLCO1B1	rsID=RefSNP accession ID number (http://www.ncbi.nlm.nih.gov/snp/)	0	1
ALLELE_DEFINITION	SLCO1B1	All variants are annotated to the positive DNA strand.	1	1
ALLELE_DEFINITION	SLCO1B1	An important caveat for all genotyping tests is that the decision to assign an allele a "wild-type" status is based upon a genotyping test that interrogates only the most common and already-proven sites of functional variation. In human DNA, it is always possible that a new, previously undiscovered (and therefore un-interrogated) site of variation may confer loss-of-function in an individual, and thus lead to the rare possibility of a non-functional allele being erroneously called as "wild-type."	2	1
ALLELE_DEFINITION	SLCO1B1	Citations for assignment of function can be found at https://www.pharmgkb.org/page/slco1b1RefMaterials	3	1
ALLELE_DEFINITION	TPMT	rsID=RefSNP accession ID number (http://www.ncbi.nlm.nih.gov/snp/)	0	1
ALLELE_DEFINITION	TPMT	All variants are annotated to the positive DNA strand.	1	1
ALLELE_DEFINITION	TPMT	Variants are sourced from the TPMT nomenclature committee (TPMT Alleles), see https://liu.se/en/research/tpmt-nomenclature-committee	2	1
ALLELE_DEFINITION	UGT1A1	rsID=RefSNP accession ID number (http://www.ncbi.nlm.nih.gov/snp/)	0	1
ALLELE_DEFINITION	UGT1A1	All variants are annotated to the positive DNA strand.	1	1
ALLELE_DEFINITION	UGT1A1	To see a full list of known UGT1A1 alleles see https://www.pharmacogenomics.pha.ulaval.ca/wp-content/uploads/2015/04/UGT1A1-allele-nomenclature.html	2	1
ALLELE_DEFINITION	UGT1A1	An important caveat for all genotyping tests is that the decision to assign an allele a "wild-type" status is based upon a genotyping test that interrogates only the most common and already- proven sites of functional variation. In human DNA, it is always possible that a new, previously undiscovered (and therefore un-interrogated) site of variation may confer loss-of-function in an individual, and thus lead to the rare possibility of a non-functional allele being erroneously called as "wild-type".	3	1
ALLELE_DEFINITION	UGT1A1	Citations for assignment of function can be found at https://www.pharmgkb.org/page/ugt1a1RefMaterials	4	1
ALLELE_DEFINITION	UGT1A1	UGT1A1*80 is in very high linkage disequilibrium with *28 and *37. However, the function of the *80 allele alone, in the absence of *28 or *37, is uncertain. If a patient is only tested for *80, decreased function may be inferred, though linkage is not 100%.	5	1
ALLELE_DEFINITION	UGT1A1	TA repeat: Historically in the literature and at the UGT nomenclature website, the TA repeat is referred to as TA(6) for *1, TA(7) for *28, TA(5) for *36, etc. The UGT allele nomenclature website (https://www.pharmacogenomics.pha.ulaval.ca/wp-content/uploads/2015/04/UGT1A1-allele-nomenclature.html) defines them in more detail as for example: A(TA)6TAA to A(TA)7TAA for *28 and A(TA)6TAA to A(TA)5TAA for *36. Note that after the repeat and number, there is an additional TA listed in the flanking sequence as "TAA". Similar nomenclature/representation is in cell C2 of the table on the "Alleles" tab as historical referencing ("CA" in front as an anchor for the point in the sequence that the TA repeats are starting from). Rows 4 and 5 align with the indicated reference sequences. In cells C4 and C5, when counting from the first TA at the given position in the sequence and including the last TA, the 5, 6, 7, 8 repeats become 6, 7, 8, 9 because there are actually 6 to 9 "TA" repeats in the genomic and gene reference sequences.	6	1
ALLELE_DEFINITION	VKORC1	rsID=RefSNP accession ID number (http://www.ncbi.nlm.nih.gov/snp/)	0	1
ALLELE_DEFINITION	VKORC1	All variants are annotated to the positive DNA strand.	1	1
ALLELE_FUNCTION_REFERENCE	RYR1	Variant selection based on an update of the CPIC guideline for potent volatile anesthetic agents and succinylcholine. The guideline update includes the published list of RYR1 variants (supplemental Table S2), which are evaluated by the ClinGen malignant hyperthermia susceptibility (MHS) variant curation expert panel (VCEP) and classified for RYR1-related malignant hyperthermia susceptibility based on specified ACMG/AMP criteria (PMID 35849058). The entries in the column 'Allele Functional Status (Optional)' are from the 'Pathogenicity' column and the entries in the column 'Findings (Optional)' are from the ACMG/AMP Criteria column in Table S2 (PMID 35849058).	0	1
ALLELE_FUNCTION_REFERENCE	RYR1	Variants 1209C>G, 7522C>G, 14387A>G, 14693T>C are not included in the PMID 35849058 and are classified as VUS by the RYR1 VCEP in May 2023.	1	1
ALLELE_FUNCTION_REFERENCE	RYR1	Variant classification was re-evaluated and updated by the RYR1 VCEP in May 2023 for the following variants: c.488G>T, c.1589G>A, c.7522C>T, c.14210G>A, c.14582G>A, c.6612C>G, c.14918C>T, c.5183C>T, c.5132A>G, c.6838G>A	2	1
ALLELE_FUNCTION_REFERENCE	RYR1	Variant classification was re-evaluated and updated by the RYR1 VCEP in Nov 2023 for the following variants: c.6488G>T, c.14627A>G, c.14813T>C	3	1
ALLELE_FUNCTION_REFERENCE	RYR1	Allele Clinical Functional Status is mapped to the classification by the ClinGen malignant hyperthermia susceptibility (MHS) variant curation expert panel PMID: 35849058 as follows:	4	1
ALLELE_FUNCTION_REFERENCE	RYR1	Pathogenic = Malignant Hyperthermia associated	5	1
ALLELE_FUNCTION_REFERENCE	RYR1	Likely Pathogenic = Malignant Hyperthermia associated	6	1
ALLELE_FUNCTION_REFERENCE	RYR1	Variant of uncertain significance = Uncertain function	7	1
ALLELE_FUNCTION_REFERENCE	RYR1	Likely Benign = Normal function	8	1
ALLELE_FUNCTION_REFERENCE	RYR1	Benign = Normal function	9	1
ALLELE_FUNCTION_REFERENCE	RYR1	"Reference" is included in the CPIC RYR1 allele definition table. Allele Clinical Functional Status is assigned Normal function.	10	1
GENE_CDS	RYR1	For this example, a priority result is defined as a genetic test result that results in a change in drug, drug dose, or drug monitoring.	1	1
GENE_CDS	RYR1	The specific wording of the interpretive text may differ among sites.	2	1
FREQUENCY	HLA-B	aAverage frequencies based on the reported frequencies in one or multiple studies.	1	1
FREQUENCY	HLA-B	bBased on the PharmGKB biogeographical groups https://www.pharmgkb.org/page/biogeographicalGroups	2	1
TEST_ALERT	RxNorm:2597	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:2597	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:5691	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:5691	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:861634	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:861634	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:519	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:519	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:3328	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:3328	"Clinical pharmacist" could also be pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	1	1
TEST_ALERT	RxNorm:6572	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:6572	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:6572	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:6572	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:8120	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:8120	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
TEST_ALERT	RxNorm:8120	The specific wording of the alert text may differ among sites.	2	1
TEST_ALERT	RxNorm:8120	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenetics expertise/training.	3	1
TEST_ALERT	RxNorm:2054023	The specific wording of the alert text may differ among sites.	0	1
TEST_ALERT	RxNorm:2054023	"Clinical pharmacist" may be a pharmacist, pharmacologist, or a clinician with pharmacogenomics expertise/training.	1	1
\.


--
-- Data for Name: flyway_schema_history; Type: TABLE DATA; Schema: cpic; Owner: -
--

COPY cpic.flyway_schema_history (installed_rank, version, description, type, script, checksum, installed_by, installed_on, execution_time, success) FROM stdin;
1	1	Initial bootstrap	SQL	V1__Initial_bootstrap.sql	1343833882	cpic	2020-09-30 21:02:41.398674	17646	t
2	2	initial data	SQL	V2__initial_data.sql	1569953039	cpic	2020-09-30 21:03:00.181244	1464	t
3	3	views	SQL	V3__views.sql	1637573145	cpic	2020-09-30 21:03:02.68466	2906	t
4	4	flow charts	SQL	V4__flow_charts.sql	-461764197	cpic	2020-09-30 21:03:06.637242	3674	t
5	6	nsaid release	SQL	V6__nsaid_release.sql	1899796322	cpic	2020-09-30 21:03:11.349979	2479	t
6	7	nsaid pair data	SQL	V7__nsaid_pair_data.sql	-1759040576	cpic	2020-09-30 21:03:14.862537	1507	t
7	8	data progress view	SQL	V8__data_progress_view.sql	-583739949	cpic	2020-09-30 21:03:17.405314	325	t
8	9	file view	SQL	V9__file_view.sql	-435728782	cpic	2020-09-30 21:03:18.784115	320	t
9	10	pair data update	SQL	V10__pair_data_update.sql	1561416759	cpic	2020-09-30 21:03:20.133162	720	t
10	11	guideline in drug model	SQL	V11__guideline_in_drug_model.sql	1721141764	cpic	2020-09-30 21:03:21.898691	476	t
11	12	pair data update	SQL	V12__pair_data_update.sql	-1970090295	cpic	2020-09-30 21:03:23.402028	233	t
12	13	add publications	SQL	V13__add_publications.sql	1291951866	cpic	2020-09-30 21:03:24.679997	320	t
13	14	add highlighted publications	SQL	V14__add_highlighted_publications.sql	759335679	cpic	2020-09-30 21:03:26.044179	399	t
14	15	pair data update	SQL	V15__pair_data_update.sql	81113836	cpic	2020-09-30 21:03:27.481903	243	t
15	16	update ibuprofen ATC	SQL	V16__update_ibuprofen_ATC.sql	1407599949	cpic	2020-09-30 21:03:28.777477	243	t
16	18	allele status lookup	SQL	V18__allele_status_lookup.sql	-859499970	cpic	2020-09-30 21:03:30.070317	482	t
17	19	new publication	SQL	V19__new_publication.sql	-1342471317	cpic	2020-09-30 21:03:31.581321	315	t
18	20	update sequence IDs	SQL	V20__update_sequence_IDs.sql	-75396910	cpic	2020-09-30 21:03:32.939966	480	t
19	21	recommendation lookup fn	SQL	V21__recommendation_lookup_fn.sql	-1422255981	cpic	2020-09-30 21:03:34.466215	478	t
20	22	ppi release	SQL	V22__ppi_release.sql	-1608844545	cpic	2020-09-30 21:03:35.973984	885	t
21	23	helpful views	SQL	V23__helpful_views.sql	1737227498	cpic	2020-09-30 21:03:37.894656	1362	t
22	24	new drug flowcharts	SQL	V24__new_drug_flowcharts.sql	426101726	cpic	2020-09-30 21:03:40.286768	888	t
23	25	phenytoin guideline update	SQL	V25__phenytoin_guideline_update.sql	-746232628	cpic	2020-09-30 21:03:42.235826	481	t
24	26	validate pair pmids	SQL	V26__validate_pair_pmids.sql	-1806818774	cpic	2020-09-30 21:03:43.755407	240	t
25	27	reference allele	SQL	V27__reference_allele.sql	849245471	cpic	2020-09-30 21:03:45.03582	1701	t
26	\N	apply permissions	SQL	R__apply_permissions.sql	-1445996752	cpic	2020-09-30 21:03:47.781042	1352	t
27	28	more allele frequency	SQL	V28__more_allele_frequency.sql	805701621	cpic	2020-10-06 04:45:31.882019	65	t
28	29	gene notes on diplotype	SQL	V29__gene_notes_on_diplotype.sql	-32272162	cpic	2020-10-06 04:45:31.979835	39	t
29	30	fix diplotype note column name	SQL	V30__fix_diplotype_note_column_name.sql	-1780194441	cpic	2020-10-06 20:33:55.825135	12	t
30	31	structural variant alleles	SQL	V31__structural_variant_alleles.sql	907385290	cpic	2020-10-21 16:33:11.171586	21	t
31	32	more notes	SQL	V32__more_notes.sql	946380705	cpic	2020-10-26 04:13:26.606463	33	t
32	33	remove allele frequency	SQL	V33__remove_allele_frequency.sql	370457724	cpic	2020-10-29 02:34:55.945477	28	t
33	34	add constraints to publication	SQL	V34__add_constraints_to_publication.sql	1822736403	cpic	2020-12-07 19:33:55.270759	86	t
34	35	opioid release	SQL	V35__opioid_release.sql	-334675632	cpic	2021-01-08 00:30:17.865038	51	t
35	36	update allele view	SQL	V36__update_allele_view.sql	-926799802	cpic	2021-01-15 23:54:12.278947	96	t
36	37	remove unused column	SQL	V37__remove_unused column.sql	-2122981860	cpic	2021-03-25 17:42:36.558878	134	t
37	38	gene urls	SQL	V38__gene_urls.sql	1563545318	cpic	2021-03-25 17:42:36.742551	62	t
38	\N	apply permissions	SQL	R__apply_permissions.sql	-575065814	cpic	2021-03-25 17:42:36.82488	28	t
39	39	guideline summary view	SQL	V39__guideline_summary_view.sql	480060255	cpic	2021-03-26 20:19:53.149371	58	t
40	\N	apply permissions	SQL	R__apply_permissions.sql	-1861354715	cpic	2021-03-26 20:19:53.225004	31	t
41	40	fix flowchart urls	SQL	V40__fix_flowchart_urls.sql	-1456884835	cpic	2021-05-11 18:22:43.25079	46	t
43	42	aminoglycosides guideline	SQL	V42__aminoglycosides_guideline.sql	540949488	cpic	2021-06-14 04:40:37.690857	93	t
44	43	seq loc unique key	SQL	V43__seq_loc_unique_key.sql	-1638696174	cpic	2021-06-14 04:40:37.808891	52	t
45	44	functionmethods	SQL	V44__functionmethods.sql	2079604482	cpic	2021-06-29 15:43:53.422219	16	t
46	45	sequence location position	SQL	V45__sequence_location_position.sql	1314277241	cpic	2021-07-09 21:30:29.833003	102	t
47	46	fix dbsnpid column	SQL	V46__fix_dbsnpid_column.sql	-1850897598	cpic	2021-08-05 17:38:43.759722	21	t
48	47	guideline fns	SQL	V47__guideline_fns.sql	-1198346012	cpic	2021-08-18 22:14:26.14922	30	t
49	48	update guideline allele fn	SQL	V48__update_guideline_allele_fn.sql	-1854568090	cpic	2021-09-09 21:03:26.214156	30	t
50	49	fix allele findings	SQL	V49__fix_allele_findings.sql	976892510	cpic	2021-09-09 21:03:26.268771	65	t
51	50	fix IFNL3 lookup	SQL	V50__fix_IFNL3_lookup.sql	119727388	cpic	2021-10-13 17:22:27.82421	9	t
52	51	fix guideline allele fn	SQL	V51__fix_guideline_allele_fn.sql	798068262	cpic	2021-11-10 05:57:09.346894	62	t
53	52	recommendation alleles view	SQL	V52__recommendation_alleles_view.sql	-1879594301	cpic	2021-12-07 15:59:50.932388	98	t
54	\N	apply permissions	SQL	R__apply_permissions.sql	-1576403970	cpic	2021-12-07 15:59:51.080556	20	t
55	53	statins guideline	SQL	V53__statins_guideline.sql	-374639719	cpic	2022-02-16 23:10:42.374259	18	t
56	54	publication index	SQL	V54__publication_index.sql	-1084867310	cpic	2022-02-18 22:16:35.644864	11	t
57	55	allele frequency cache	SQL	V55__allele_frequency_cache.sql	778761699	cpic	2022-03-09 23:20:36.042025	13	t
58	56	gene legacy names	SQL	V56__gene_legacy_names.sql	-442391864	cpic	2022-03-17 23:13:23.411535	13	t
59	57	pgkb recs fn update	SQL	V57__pgkb_recs_fn_update.sql	415609266	cpic	2022-06-10 14:24:09.906199	22	t
42	41	publication files	SQL	V41__publication_files.sql	389573953	cpic	2021-05-11 18:22:43.398622	319	t
60	\N	apply permissions	DELETE	R__apply_permissions.sql	-1576403970	cpic	2022-08-16 07:29:30.595272	0	t
61	58	stats table	SQL	V58__stats_table.sql	1603923816	cpic	2022-08-16 07:35:43.159887	60	t
62	59	remove allele guideline	SQL	V59__remove_allele_guideline.sql	-1144551837	cpic	2022-09-14 17:55:53.477071	21	t
63	60	reference allele	SQL	V60__reference_allele.sql	1296637883	cpic	2022-09-14 17:55:53.52649	26	t
64	61	G6PD guideline prep	SQL	V61__G6PD_guideline_prep.sql	1983975991	cpic	2022-09-14 17:55:53.577532	28	t
65	62	G6PD flow charts	SQL	V62__G6PD_flow_charts.sql	626814934	cpic	2022-09-22 16:42:28.143006	29	t
66	63	fosphenytoin flow chart	SQL	V63__fosphenytoin_flow_chart.sql	1952328724	cpic	2022-09-30 13:34:29.608278	28	t
67	64	recommendation flags	SQL	V64__recommendation_flags.sql	-797174188	cpic	2023-02-27 19:42:13.143746	42	t
68	65	frequency flags	SQL	V65__frequency_flags.sql	-477833361	cpic	2023-03-23 11:54:36.147354	42	t
69	66	ssri snri guideline	SQL	V66__ssri_snri_guideline.sql	-1949888557	cpic	2023-04-12 19:43:47.434594	34	t
70	67	frequency view fix	SQL	V67__frequency_view_fix.sql	-1816979743	cpic	2023-09-01 14:42:15.154823	41	t
71	68	fix function definitions	SQL	V68__fix_function_definitions.sql	1243132888	cpic	2024-01-12 20:33:40.207106	11	t
72	69	change log releases	SQL	V69__change_log_releases.sql	1272931372	cpic	2024-05-09 15:03:57.003783	276	t
73	70	fix allele freq view	SQL	V70__fix_allele_freq_view.sql	-957778206	cpic	2024-10-03 15:13:15.938037	9	t
74	71	fix guideline summary view	SQL	V71__fix_guideline_summary_view.sql	-1334280856	cpic	2025-03-07 16:21:39.906989	8	t
\.


--
-- Data for Name: gene; Type: TABLE DATA; Schema: cpic; Owner: -
--

COPY cpic.gene (symbol, chr, genesequenceid, proteinsequenceid, chromosequenceid, mrnasequenceid, hgncid, ncbiid, ensemblid, pharmgkbid, frequencymethods, lookupmethod, version, notesondiplotype, url, functionmethods, notesonallelenaming, includephenotypefrequencies, includediplotypefrequencies) FROM stdin;
ERCC1	chr19	NG_015839	NP_001974	\N	\N	HGNC:3433	2067	ENSG00000012061	PA155	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
POLG	chr15	NG_008218	NP_002684	\N	\N	HGNC:9179	5428	ENSG00000140521	PA33500	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
ASS1	chr9	NG_011542	NP_000041	\N	\N	HGNC:758	445	ENSG00000130707	PA162376926	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
DRD2	chr11	NG_008841	NP_000786	\N	\N	HGNC:3023	1813	ENSG00000149295	PA27478	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
ATIC	chr2	NG_013002	NP_004035	\N	\N	HGNC:794	471	ENSG00000138363	PA25094	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
APOE	chr19	NG_007084	NP_000032	\N	\N	HGNC:613	348	ENSG00000130203	PA55	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
GSTM1	chr1	NG_009246	NP_000552	\N	\N	HGNC:4632	2944	ENSG00000134184	PA182	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
F5	chr1	NG_011806	NP_000121	\N	\N	HGNC:3542	2153	ENSG00000198734	PA159	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
CYB5R3	chr22	NG_012194	NP_000389	\N	\N	HGNC:2873	1727	ENSG00000100243	PA27331	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
CHRNA3	chr15	NG_016143	NP_000734	\N	\N	HGNC:1957	1136	ENSG00000080644	PA113	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
HMGCR	chr5	NG_011449	NP_000850	\N	\N	HGNC:5006	3156	ENSG00000113161	PA189	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
CRHR1	chr17	NG_009902	NP_004373	\N	\N	HGNC:2357	1394	ENSG00000120088	PA26874	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
ITPA	chr20	NG_012093	NP_258412	\N	\N	HGNC:6176	3704	ENSG00000125877	PA29973	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
MC4R	chr18	NG_016441	NP_005903	\N	\N	HGNC:6932	4160	ENSG00000166603	PA30676	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
COQ2	chr4	NG_015825	NP_056512	\N	\N	HGNC:25223	27235	ENSG00000173085	PA142672084	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
HTR2C	chrX	NG_012082	NP_000859	\N	\N	HGNC:5295	3358	ENSG00000147246	PA194	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
OTC	chrX	NG_008471	NP_000522	\N	\N	HGNC:8512	5009	ENSG00000036473	PA32840	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
MTRR	chr5	NG_008856	NP_002445	\N	\N	HGNC:7473	4552	ENSG00000124275	PA31277	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
LPA	chr6	NG_016147	NP_005568	\N	\N	HGNC:6667	4018	ENSG00000198670	PA30432	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
NAT1	chr8	NG_012245	NP_000653	\N	\N	HGNC:7645	9	ENSG00000171428	PA17	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
CPS1	chr2	NG_008285	NP_001866	\N	\N	HGNC:2323	1373	ENSG00000021826	PA26840	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
EGF	chr4	NG_011441	NP_001954	\N	\N	HGNC:3229	1950	ENSG00000138798	PA27664	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
DYNC2H1	chr11	NG_016423	NP_001368	\N	\N	HGNC:2962	79659	ENSG00000187240	PA27433	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
GNB3	chr12	NG_009100	NP_002066	\N	\N	HGNC:4400	2784	ENSG00000111664	PA176	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
SEMA3C	chr7	\N	NP_006370	\N	\N	HGNC:10725	10512	ENSG00000075223	PA35647	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
KIF6	chr6	\N	NP_659464	\N	\N	HGNC:21202	221458	ENSG00000164627	PA134920075	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
CCHCR1	chr6	\N	NP_061925	\N	\N	HGNC:13930	54535	ENSG00000204536	PA134942738	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
FCGR3A	chr1	NG_009066	NP_000560	\N	\N	HGNC:3619	2214	ENSG00000203747	PA28065	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
NAGS	chr17	NG_008106	NP_694551	\N	\N	HGNC:17996	162417	ENSG00000161653	PA134968729	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
LDLR	chr19	NG_009060	NP_000518	\N	\N	HGNC:6547	3949	ENSG00000130164	PA227	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
ASL	chr7	NG_009288	NP_000039	\N	\N	HGNC:746	435	ENSG00000126522	PA25046	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
HPRT1	chrX	NG_012329	NP_000185	\N	\N	HGNC:5157	3251	ENSG00000165704	PA29427	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
ANKK1	chr11	NG_012976	NP_848605	\N	\N	HGNC:21027	255239	ENSG00000170209	PA134872551	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
XPC	chr3	NG_011763	NP_004619	\N	\N	HGNC:12816	7508	ENSG00000154767	PA37413	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
DPYD	chr1	NG_008807.2	NP_000101.2	NC_000001.11	NM_000110.4	HGNC:3012	282617	ENSG00000188641	PA145	Methods:\nThe DPYD frequency table was created using data from ExAC (http://exac.broadinstitute.org/) and the 1000 Genomes project (http://www.ensembl.org/Homo_sapiens/Info/Index).\nThe average allele frequencies by race were calculated by taking the number with the variant in all studies divided by the total number of individuals tested for the variant in all studies.\nAll nucleotide changes are according to reference sequence NM_000110.3 and all protein changes are according to reference sequence NP_000101.2\nCaveats\nIf 1000 Genomes and/or ExAC did not return any frequency data for a given variant, cells were left blank\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details can be found at https://www.pharmgkb.org/page/biogeographicalGroups. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.\n\n\n\n\n\n\n\n	ACTIVITY_SCORE	376	The DPYD phenotype is assigned using a gene activity score (DPYD-AS; based on the DPYD Allele Functionality Table), calculated as the sum of the two DPYD variants with the lowest variant activity value. Briefly, carriers of two no function variants (DPYD-AS: 0) OR one decreased function variant (DPD-AS: 0.5) are classified as DPYD poor metabolizers; carriers of two decreased function variants OR carriers of only one no function variant (DPYD-AS: 1) OR carriers of only one decreased function variant (DPYD-AS: 1.5) are considered DPYD intermediate metabolizers , and those with only normal function variants are classified as DPYD normal metabolizers (DPYD-AS: 2). If two decreased/no function variants are present, each decreased/no function variant is considered to be on a different gene copy. Irrespective of the presence of decreased/no function variants, patients may carry multiple normal function variants. As an individual only carries a maximum of two fully functional DPYD copies, common normal function variants may be located on the same gene copy as other normal function variants or decreased/no function variants.	https://cpicpgx.org/gene/dpyd/	\N	Legacy Name/Class	f	f
ADRB2	chr5	NG_016421	NP_000015	\N	\N	HGNC:286	154	ENSG00000169252	PA39	\N	PHENOTYPE	3	\N	https://cpicpgx.org/gene/adrb2/	\N	\N	t	t
ADRA2C	\N	\N	\N	\N	\N	HGNC:283	152	ENSG00000184160	PA37	\N	PHENOTYPE	8	\N	https://cpicpgx.org/gene/adra2c/	\N	\N	t	t
CALU	chr7	\N	NP_001210	\N	\N	HGNC:1458	813	ENSG00000128595	PA26047	\N	PHENOTYPE	96	\N	\N	\N	\N	t	t
CES1	chr16	NG_012057	NP_001257	\N	\N	HGNC:1863	1066	ENSG00000198848	PA107	\N	PHENOTYPE	95	\N	\N	\N	\N	t	t
FKBP5	chr6	NG_012645	NP_004108	\N	\N	HGNC:3721	2289	ENSG00000096060	PA28162	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
ACE	chr17	NG_011648	NP_000780	\N	\N	HGNC:2707	1636	ENSG00000159640	PA139	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
TXNRD2	chr22	NG_011835	NP_006431	\N	\N	HGNC:18155	10587	ENSG00000184470	PA38302	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
GBA	chr1	NG_009783	NP_000148	\N	\N	HGNC:4177	2629	ENSG00000177628	PA28591	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
HLA-DRB1	chr6	NG_002392	NP_002115	\N	\N	HGNC:4948	3123	ENSG00000196126	PA35072	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
CETP	chr16	NG_008952	NP_000069	\N	\N	HGNC:1869	1071	ENSG00000087237	PA108	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
UGT1A4	chr2	NG_002601	NP_009051	\N	\N	HGNC:12536	54657	ENSG00000244474	PA37179	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
TP53	chr17	NG_017013	NP_000537	\N	\N	HGNC:11998	7157	ENSG00000141510	PA36679	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
PRKCA	chr17	NG_012206	NP_002728	\N	\N	HGNC:9393	5578	ENSG00000154229	PA33759	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
TCF7L2	chr10	NG_012631	NP_110383	\N	\N	HGNC:11641	6934	ENSG00000148737	PA36394	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
ADD1	chr4	NG_012037	NP_001110	\N	\N	HGNC:243	118	ENSG00000087274	PA31	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
TMEM43	chr3	NG_008975	NP_077310	\N	\N	HGNC:28472	79188	ENSG00000170876	PA134871907	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
SOD2	chr6	NG_008729	NP_000627	\N	\N	HGNC:11180	6648	ENSG00000112096	PA36017	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
SERPINC1	chr1	NG_012462	NP_000479	\N	\N	HGNC:775	462	ENSG00000117601	PA35026	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
TNF	chr6	NG_007462	NP_000585	\N	\N	HGNC:11892	7124	ENSG00000232810	PA435	\N	PHENOTYPE	2	\N	\N	\N	\N	t	t
C11orf65	chr11	\N	NP_689800	\N	\N	HGNC:28519	160140	ENSG00000166323	PA144596484	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
HAS3	chr16	\N	NP_005320	\N	\N	HGNC:4820	3038	ENSG00000103044	PA29196	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
SLC47A2	chr17	\N	NP_001093116	\N	\N	HGNC:26439	146802	ENSG00000180638	PA162403847	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
CBR3	chr21	\N	NP_001227	\N	\N	HGNC:1549	874	ENSG00000159231	PA26122	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
NT5C2	chr10	\N	NP_036361	\N	\N	HGNC:8022	22978	ENSG00000076685	PA31801	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
NEDD4L	chr18	\N	NP_056092	\N	\N	HGNC:7728	23327	ENSG00000049759	PA31534	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
CYB5R1	chr1	\N	NP_057327	\N	\N	HGNC:13397	51706	ENSG00000159348	PA134979668	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
SLC28A3	chr9	\N	NP_071410	\N	\N	HGNC:16484	64078	ENSG00000197506	PA426	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
FDPS	chr1	\N	NP_001995	\N	\N	HGNC:3631	2224	ENSG00000160752	PA28075	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
PTGFR	chr1	\N	NP_000950	\N	\N	HGNC:9600	5737	ENSG00000122420	PA290	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
KCNIP4	chr4	\N	NP_671711	\N	\N	HGNC:30083	80333	ENSG00000185774	PA134893552	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
HLA-DQA1	chr6	\N	NP_002113	\N	\N	HGNC:4942	3117	ENSG00000196735	PA35066	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
ABCC4	chr13	\N	NP_005836	\N	\N	HGNC:55	10257	ENSG00000125257	PA397	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
ABL2	chr1	\N	NP_005149	\N	\N	HGNC:77	27	ENSG00000143322	PA24414	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
UGT2B15	chr4	\N	NP_001067	\N	\N	HGNC:12546	7366	ENSG00000196620	PA37188	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
YEATS4	chr12	\N	NP_006521	\N	\N	HGNC:24859	8089	ENSG00000127337	PA134992686	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
TANC1	chr2	\N	NP_203752	\N	\N	HGNC:29364	85461	ENSG00000115183	PA142670838	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
CRHR2	chr7	\N	NP_001874	\N	\N	HGNC:2358	1395	ENSG00000106113	PA26875	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
CYB5R2	chr11	\N	NP_057313	\N	\N	HGNC:24376	51700	ENSG00000166394	PA142672060	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
XRCC1	chr19	\N	NP_006288	\N	\N	HGNC:12828	7515	ENSG00000073050	PA369	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
COL22A1	chr8	\N	NP_690848	\N	\N	HGNC:22989	169044	ENSG00000169436	PA134914705	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
CYB5R4	chr6	\N	NP_057314	\N	\N	HGNC:20147	51167	ENSG00000065615	PA134904907	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
C8orf34	chr8	\N	NP_443190	\N	\N	HGNC:30905	116328	ENSG00000165084	PA142672353	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
ADORA2A	chr22	\N	NP_000666	\N	\N	HGNC:263	135	ENSG00000128271	PA24584	\N	PHENOTYPE	3	\N	\N	\N	\N	t	t
MT-RNR1	chrM	NG_042193.1	NP_000101.2	NC_012920.1	NM_001042351.2	HGNC:7470	4549	ENSG00000211459	PA31274	Methods\n\nThe allele frequency table was made by searching the PubMed® database (1995 to September 2019). The following criteria were used for MT-RNR1: (Mitochondrial AND (A1555G OR C1494T OR T1095C) AND frequency). In addition, reports were also identified from citations by others or review articles. Studies were considered for inclusion in the MT-RNR1 frequency table if: (1) the ethnicity of the population was clearly indicated, (2) the method by which the genes were genotyped was indicated, (3) the sample population consisted of at least 50 individuals with a few exceptions (e.g., smaller cohorts that were part of larger studies) and (4) the study represented an original publication (no reviews or meta-analyses). Homoplasmic allele frequencies reported in gnomAD (https://gnomad.broadinstitute.org/) were also included .\nCaveats to estimated allele, diplotype and phenotype frequencies:\n\nSampling. Allele frequencies collected by CPIC for the supplemental tables are based on published literature reports which typically study small groups of people based on a geographic location (e.g. Malaysia, Berlin, Cairo). Almost no studies use genetic markers to estimate ancestry. Manuscripts are often focused on a specific phenotype (e.g. disease) or study only individuals taking a particular drug. Such samples would not be considered a random sample of the general population. Another consideration is that sample size is important, and PGx studies are typically not large. The frequencies collected from these studies are then used to estimate general estimates of entire ethnic population allele frequencies. Therefore, frequencies from larger groups of subjects and frequencies averaged from many sample populations probably result in better estimates.\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details, including the definitions of each group, can be found at https://www.pharmgkb.org/page/biogeographicalGroups. We strongly recommend that users use either the publication or the PharmGKB link provided to familiarize themselves with the grouping system before using these allele frequencies. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.	PHENOTYPE	331	\N	https://cpicpgx.org/gene/mt-rnr1/	\N	Common name	f	f
ADRB1	\N	\N	\N	\N	\N	HGNC:285	153	ENSG00000043591	PA38	\N	PHENOTYPE	94	\N	https://cpicpgx.org/gene/adrb1/	\N	\N	t	t
CYP2A7P1	chr19	NG_000008	\N	\N	\N	HGNC:2612	1550	ENSG00000213908	PA27103	\N	PHENOTYPE	96	\N	\N	\N	\N	t	t
FLOT1	chr6	\N	NP_005794	\N	\N	HGNC:3757	10211	ENSG00000137312	PA28175	\N	PHENOTYPE	96	\N	\N	\N	\N	t	t
GRIK4	chr11	\N	NP_055434	\N	\N	HGNC:4582	2900	ENSG00000149403	PA28976	\N	PHENOTYPE	96	\N	\N	\N	\N	t	t
GRK4	\N	\N	\N	\N	\N	HGNC:4543	2868	ENSG00000125388	PA28941	\N	PHENOTYPE	8	\N	https://cpicpgx.org/gene/grk4/	\N	\N	t	t
GRK5	\N	\N	\N	\N	\N	HGNC:4544	2869	ENSG00000198873	PA180	\N	PHENOTYPE	94	\N	https://cpicpgx.org/gene/grk5/	\N	\N	t	t
HLA-C	chr6	NG_002397	NP_002108	\N	\N	HGNC:4933	3107	ENSG00000204525	PA35057	\N	PHENOTYPE	95	\N	\N	\N	\N	t	t
HLA-DPB1	chr6	\N	NP_002112	\N	\N	HGNC:4940	3115	ENSG00000223865	PA35064	\N	PHENOTYPE	96	\N	\N	\N	\N	t	t
HTR1A	chr5	\N	NP_000515	\N	\N	HGNC:5286	3350	ENSG00000178394	PA192	\N	PHENOTYPE	96	\N	\N	\N	\N	t	t
IFNL4	chr19	\N	\N	\N	\N	HGNC:44480	101180976	ENSG00000272395	PA166049147	\N	PHENOTYPE	98	\N	https://cpicpgx.org/gene/ifnl/	\N	\N	t	t
LTC4S	chr5	\N	NP_665874	\N	\N	HGNC:6719	4056	ENSG00000213316	PA235	\N	PHENOTYPE	96	\N	\N	\N	\N	t	t
NAT2	chr8	NG_012246	NP_000006	\N	\N	HGNC:7646	10	ENSG00000156006	PA18	\N	PHENOTYPE	95	\N	\N	\N	\N	t	t
OPRM1	chr6	NG_021208	NP_000905	\N	\N	HGNC:8156	4988	ENSG00000112038	PA31945	\N	PHENOTYPE	89	\N	https://cpicpgx.org/gene/oprm1/	\N	\N	t	t
PTGS1	chr9	\N	NP_000953	\N	\N	HGNC:9604	5742	ENSG00000095303	PA24346	\N	PHENOTYPE	96	\N	\N	\N	\N	t	t
HLA-A	chr6	NG_002398	NP_002107	\N	\N	HGNC:4931	3105	ENSG00000206503	PA35055	Methods\n\nThe allele frequency table was made by searching the PubMed® database (1995 to September 2019). The following criteria were used for HLA-A: (HLA-A) AND (allele OR frequency). In addition, reports were also identified from citations by others or review articles. Studies were considered for inclusion in the HLA-A frequency table if: (1) the ethnicity of the population was clearly indicated, (2) either allele frequencies or genotype frequencies were reported, (3) the method by which the genes were genotyped was indicated, (4) the sample population consisted of at least 50 individuals with a few exceptions (e.g., smaller cohorts that were part of larger studies) and (5) the study represented an original publication (no reviews or meta-analyses). Allele frequencies reported in phase 3 1000 Genomes (http://browser.1000genomes.org/index.html) and from allelefrequencies.net (https://www.allelefrequencies.net) were also included .\nCaveats to estimated allele frequencies:\n\nSampling. Allele frequencies collected by CPIC for the supplemental tables are based on published literature reports which typically study small groups of people based on a geographic location (e.g. Malaysia, Berlin, Cairo). Almost no studies use genetic markers to estimate ancestry. Manuscripts are often focused on a specific phenotype (e.g. disease) or study only individuals taking a particular drug. Such samples would not be considered a random sample of the general population. Another consideration is that sample size is important, and PGx studies are typically not large. The frequencies collected from these studies are then used to estimate general estimates of entire ethnic population allele frequencies. Therefore, frequencies from larger groups of subjects and frequencies averaged from many sample populations probably result in better estimates.\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details, including the definitions of each group, can be found at https://www.pharmgkb.org/page/biogeographicalGroups. We strongly recommend that users use either the publication or the PharmGKB link provided to familiarize themselves with the grouping system before using these allele frequencies. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.	ALLELE_STATUS	187	\N	https://cpicpgx.org/gene/hla/	\N	\N	f	f
NUDT15	chr13	NG_047021.1	NP_060753.1	NC_000013.11	NM_001042351.2	HGNC:23063	55270	ENSG00000136159	PA134963132	The allele frequency table was made by searching the PubMed® database (no start date to 1/2018). Allele frequencies reported in the gnomAD browser (http://gnomad.broadinstitute.org/ - exomes and genomes) and ensembl (grch37.ensembl.org - exomes or genomes) were also included. URLs are included in the "PMID" column.\n\nDiplotype and phenotype frequencies were estimated using the equation describing Hardy Weinberg equilibrium based on reported allele frequencies.\n\nCaveats to estimated allele, diplotype and phenotype frequencies:\n\nSampling. Allele frequencies collected by CPIC for the supplemental tables are based on published literature reports which typically study small groups of people based on a geographic location (e.g. Malaysia, Berlin, Cairo). Almost no studies use genetic markers to estimate ancestry. Manuscripts are often focused on a specific phenotype (e.g. disease) or study only individuals taking a particular drug. Such samples would not be considered a random sample of the general population. Another consideration is that sample size is important, and PGx studies are typically not large. The frequencies collected from these studies are then used to estimate general estimates of entire ethnic population allele frequencies. Therefore, frequencies from larger groups of subjects and frequencies averaged from many sample populations probably result in better estimates.\n\nEstimation of *1 frequency. In general, there are no population studies that test for all known variant alleles. Because *1 is not genotyped directly in many studies, all alleles that are negative for a sequence variation are defaulted to a *1 assignment. The inferred frequency for *1 is estimated as: 100 - (sum of averaged variant allele frequencies). For genes where many alleles are not tested for in any population, and frequency of 'common' alleles is not well documented in many understudied populations (Oceania, South Asian, Latino), the *1 frequency will deviate even more from true values.\n\nDiplotype/Phenotype frequency estimates. Diplotype and phenotype frequencies were estimated using the equation describing Hardy Weinberg equilibrium based on reported allele frequencies. When calculating diplotype frequencies from these allele frequencies, the margin of error is compounded based on the margin of error on each allele in the diplotype. So, the margin of error will necessarily increase for diplotype frequency estimates compared to allele frequency estimates. For allele frequencies with already large margins of error due to small and non-random sampling, the diplotype margin of error could potentially be quite large. On the other hand, for well-studied alleles, the margin of error is likely low.\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details can be found at https://www.pharmgkb.org/page/biogeographicalGroups. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.	PHENOTYPE	367	\N	https://cpicpgx.org/gene/nudt15/	\N	Common name	t	t
RYR1	chr19	NG_008866.1	NP_000531.2	NC_000019.10	NM_000540.2	HGNC:10483	6261	ENSG00000196218	PA34896	Methods\n\nTable includes variants based on an update of the CPIC guideline for potent volatile anesthetic agents and succinylcholine. The guideline update includes the published list of RYR1 variants (supplemental table S2), which are evaluated by the ClinGen malignant hyperthermia susceptibility (MHS) variant curation expert panel and classified for RYR1-related malignant hyperthermia susceptibility based on specified ACMG/AMP criteria (PMID 35849058).\n\ngnomAD v2.1.1 was queried with the variant positions or rsIDs.\ngnomAD population description - PharmGKB biogeographical group mapping:\nAfrican/African American - Sub-Saharan African\nSouth Asian - Central/South Asian\nLatino/Admixed American - Latino\nEast Asian - East Asian\nNon-Finnish European - European\nAshkenazi Jewish - Near Eastern\n\nCaveats to estimated allele, frequencies:\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details, including the definitions of each group, can be found at https://www.pharmgkb.org/page/biogeographicalGroups. We strongly recommend that users use either the publication or the PharmGKB link provided to familiarize themselves with the grouping system before using these allele frequencies. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.	PHENOTYPE	367	\N	https://cpicpgx.org/gene/ryr1/	\N	Common name	f	f
ABCB1	chr7	NG_011513	NP_000918	\N	\N	HGNC:40	5243	ENSG00000085563	PA267	\N	PHENOTYPE	95	\N	\N	\N	\N	t	t
TYMS	chr18	\N	NP_001062	\N	\N	HGNC:12441	7298	ENSG00000176890	PA359	\N	PHENOTYPE	96	\N	\N	\N	\N	t	t
BCHE	chr3	NG_009031	NP_000046	\N	\N	HGNC:983	590	ENSG00000114200	PA25294	\N	PHENOTYPE	95	\N	\N	\N	\N	t	t
ACYP2	\N	\N	\N	\N	\N	HGNC:180	98	ENSG00000170634	PA24500	\N	PHENOTYPE	69	\N	\N	\N	\N	t	t
UMPS	chr3	NG_017037	NP_000364	\N	\N	HGNC:12563	7372	ENSG00000114491	PA363	\N	PHENOTYPE	95	\N	\N	\N	\N	t	t
CFTR	chr7	NG_016465.4	NP_000483.3	NC_000007.14	NM_000069.2	HGNC:1884	1080	ENSG00000001626	PA109	\N	PHENOTYPE	281	\N	https://cpicpgx.org/gene/cftr/	\N	Legacy Name/Class	t	t
CYP2C9	chr10	NG_008385.2	NP_000762.2	NC_000010.11	NM_000069.2	HGNC:2623	1559	ENSG00000138109	PA126	Methods\n\nThe allele frequency table was made by searching the PubMed® database (1995 to July 2019). The following criteria were used for CYP2C9: (CYP2C9 or 2C9 or cytochrome P4502C9) AND (genotype OR allele OR frequency OR minor allele OR variant OR ethnic OR race OR racial OR ethnicity OR population) with filter limits set to retrieve "full-text" and "English" literature. In addition, reports were also identified from citations by others or review articles. Studies were considered for inclusion in the CYP2C9 frequency table if: (1) the ethnicity of the population was clearly indicated, (2) either allele frequencies or genotype frequencies were reported, (3) the method by which the genes were genotyped was indicated, (4) the sample population consisted of at least 50 individuals with a few exceptions (e.g., smaller cohorts that were part of larger studies) and (5) the study represented an original publication (no reviews or meta-analyses). Allele frequencies reported in and gnomD browser and phase 3 1000 Genomes were also included (https://gnomad.broadinstitute.org/, http://browser.1000genomes.org/index.html) for alleles that contain single unique variant.\n\nDiplotype and Phenotype Calculations. Diplotype and phenotype frequencies were estimated using the equation describing Hardy Weinberg equilibrium based on reported allele frequencies.\n\nCaveats to estimated allele, diplotype and phenotype frequencies:\n\nSampling. Allele frequencies collected by CPIC for the supplemental tables are based on published literature reports which typically study small groups of people based on a geographic location (e.g. Malaysia, Berlin, Cairo). Almost no studies use genetic markers to estimate ancestry. Manuscripts are often focused on a specific phenotype (e.g. disease) or study only individuals taking a particular drug. Such samples would not be considered a random sample of the general population. Another consideration is that sample size is important, and PGx studies are typically not large. The frequencies collected from these studies are then used to estimate general estimates of entire ethnic population allele frequencies. Therefore, frequencies from larger groups of subjects and frequencies averaged from many sample populations probably result in better estimates.\n\nEstimation of *1 frequency. In general, there are no population studies that test for all known variant alleles. Because *1 is not genotyped directly in many studies, all alleles that are negative for a sequence variation are defaulted to a *1 assignment. Because CYP2C9*1 is not genotyped directly, all alleles that are negative for a sequence variation are defaulted to a CYP2C9*1 assignment. Likewise, sequence variations of alleles that are not tested may default to a CYP2C9*1 assignment and hence contribute to the frequencies reported for this allele. Therefore, the inferred frequency for CYP2C9*1 was calculated as an average from studies describing allele frequencies for the most common alleles found in a particular biogeographical group.\n\nDiplotype/Phenotype frequency estimates. When calculating diplotype frequencies from these allele frequencies, the margin of error is compounded based on the margin of error on each allele in the diplotype. So, the margin of error will necessarily increase for diplotype frequency estimates compared to allele frequency estimates. For allele frequencies with already large margins of error due to small and non-random sampling, the diplotype margin of error could potentially be quite large. On the other hand, for well-studied alleles, the margin of error is likely low.\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details can be found at https://www.pharmgkb.org/page/biogeographicalGroups. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.	ACTIVITY_SCORE	378	CYP2C9 diplotype to phenotype translation is not applicable to the warfarin guideline.	https://cpicpgx.org/gene/cyp2c9/	Methods:\nThe PubMed and PharmGKB databases were searched for the following keywords: (CYP2C9 OR cytochrome p450 2c9)AND [genomic identifiers (e.g. dbSNP rs number, star alleles, additional common names)] AND English [Language]. Study inclusion criteria included publications that incorporated analyses for the association between CYP2C9 genotype and drug pharmacokinetic parameters, clinical outcomes, or allele function.	Legacy Name/Class	t	t
HLA-B	chr6	NG_002397	NP_005505	\N	\N	HGNC:4932	3106	ENSG00000234745	PA35056	Methods\n\nThe allele frequency table was made by searching the PubMed® database (1995 to September 2019). The following criteria were used for HLA-B: (HLA-B) AND (allele OR frequency). In addition, reports were also identified from citations by others or review articles. Studies were considered for inclusion in the HLA-B frequency table if: (1) the ethnicity of the population was clearly indicated, (2) either allele frequencies or genotype frequencies were reported, (3) the method by which the genes were genotyped was indicated, (4) the sample population consisted of at least 50 individuals with a few exceptions (e.g., smaller cohorts that were part of larger studies) and (5) the study represented an original publication (no reviews or meta-analyses). Allele frequencies reported in phase 3 1000 Genomes (http://browser.1000genomes.org/index.html) and from allelefrequencies.net (https://www.allelefrequencies.net) were also included .\nCaveats to estimated allele, diplotype and phenotype frequencies:\n\nSampling. Allele frequencies collected by CPIC for the supplemental tables are based on published literature reports which typically study small groups of people based on a geographic location (e.g. Malaysia, Berlin, Cairo). Almost no studies use genetic markers to estimate ancestry. Manuscripts are often focused on a specific phenotype (e.g. disease) or study only individuals taking a particular drug. Such samples would not be considered a random sample of the general population. Another consideration is that sample size is important, and PGx studies are typically not large. The frequencies collected from these studies are then used to estimate general estimates of entire ethnic population allele frequencies. Therefore, frequencies from larger groups of subjects and frequencies averaged from many sample populations probably result in better estimates.\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details, including the definitions of each group, can be found at https://www.pharmgkb.org/page/biogeographicalGroups. We strongly recommend that users use either the publication or the PharmGKB link provided to familiarize themselves with the grouping system before using these allele frequencies. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.	ALLELE_STATUS	187	\N	https://cpicpgx.org/gene/hla/	\N	\N	f	f
VDR	chr12	NG_008731	NP_000367	\N	\N	HGNC:12679	7421	ENSG00000111424	PA37301	\N	PHENOTYPE	95	\N	\N	\N	\N	t	t
CYP2D6	chr22	NG_008376.4	NP_000097.3	NC_000022.11	NM_000069.2	HGNC:2625	1565	ENSG00000100197	PA128	Methods:\n\nThe CYP2D6 allele frequency tables (CYP2D6 frequency table; link to PharmGKB) are updates of those previously published in CPIC guidelines (PMID: 25974703, 24458010). Updates to the CYP2D6 allele frequency tables were made by searching the PubMed® database (1995 to 2018). The following criteria were used for CYP2D6: (CYP2D6 or 2D6 or cytochrome P4502D6) AND (genotype OR allele OR frequency OR minor allele OR variant OR ethnic OR race OR racial OR ethnicity) with filter limits set to retrieve "full-text" and "English" literature. In addition, reports were also identified from citations by others or review articles. Studies were considered for inclusion in the CYP2D6 frequency table if: (1) the ethnicity of the population was clearly indicated, (2) either allele frequencies or genotype frequencies were reported, (3) the method by which the genes were genotyped was indicated, (4) the sample population consisted of at least 50 individuals with a few exceptions (e.g., smaller cohorts that were part of larger studies) and (5) the study represented an original publication (no reviews or meta-analyses).\nDiplotype and phenotype frequencies were estimated using the equation describing Hardy Weinberg equilibrium based on reported allele frequencies. Because the frequencies for each allele are averages from all studies for that population, allele frequencies may not add up to100%. To account for this in diplotype and phenotype frequencies calculations, *1 frequency was calculated as 1 - sum (non *1 allele frequency).\n\n\nCaveats to estimated allele, diplotype and phenotype frequencies:\n\nSampling. Allele frequencies collected by CPIC for the supplemental tables are based on published literature reports which typically study small groups of people based on a geographic location (e.g. Malaysia, Berlin, Cairo). Almost no studies use genetic markers to estimate ancestry. Manuscripts are often focused on a specific phenotype (e.g. disease) or study only individuals taking a particular drug. Such samples would not be considered a random sample of the general population. Another consideration is that sample size is important, and PGx studies are typically not large. The frequencies collected from these studies are then used to estimate general estimates of entire ethnic population allele frequencies. Therefore, frequencies from larger groups of subjects and frequencies averaged from many sample populations probably result in better estimates.\n\nEstimation of *1 frequency. In general, there are no population studies that test for all known variant alleles. Because CYP2D6*1 is not genotyped directly, all alleles that are negative for a sequence variation are defaulted to a CYP2D6*1 assignment. Likewise, sequence variations of alleles that are not tested may default to a CYP2D6*1 assignment and hence contribute to the frequencies reported for this allele. Therefore, the inferred frequency for CYP2D6*1 was calculated as an average from studies describing allele frequencies for the most common alleles found in a particular ethnic group.\n\nDiplotype/Phenotype frequency estimates. When calculating diplotype frequencies from these allele frequencies, the margin of error is compounded based on the margin of error on each allele in the diplotype. So, the margin of error will necessarily increase for diplotype frequency estimates compared to allele frequency estimates. For allele frequencies with already large margins of error due to small and non-random sampling, the diplotype margin of error could potentially be quite large. On the other hand, for well-studied alleles, the margin of error is likely low.\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details, including the definitions of each group, can be found at https://www.pharmgkb.org/page/biogeographicalGroups. We strongly recommend that users use either the publication or the PharmGKB link provided to familiarize themselves with the grouping system before using these allele frequencies. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.\n\nOverestimation of allele frequencies. CYP2D6*2 is a 'default' assignment and, unless tested and discriminated for CYP2D6*8, *11, *17, *35,*41 and other variants, will default to a CYP2D6*2 assignment. The frequencies shown here may therefore be over-estimated. CYP2D6*10 is a 'default' assignment and, unless tested and discriminated for, CYP2D6*14 and *36 and other variants, will default to a CYP2D6*10 assignment. The frequencies shown here may therefore be over-estimated. CYP2D6*17 is a 'default' assignment and, unless tested and discriminated for, CYP2D6*40 and *58 will default to a CYP2D6*17 assignment. The frequencies shown here may therefore be over-estimated. CYP2D6*41 has not consistently been determined by its defining SNP (2988G>A) across studies; some platforms still use the -1584C>G SNP to discriminate between CYP2D6*2 and *41. This may lead to an overestimation of the CYP2D6*41 frequency, especially in those of African ancestry.\n\nCNV alleles. Many studies do not specify the exact copy number of duplicated alleles found in their study population and instead report the total frequency of observed CNVs as "xN". Where possible, these frequencies have been included in the CNV column for that allele (e.g. *1xN frequencies are included in the *1x2 column, *4xN frequencies are included in the *4x2 column). Users should be aware that this will lead to an overestimation of the frequency of that exact copy number in the population.	ACTIVITY_SCORE	373	\N	https://cpicpgx.org/gene/cyp2d6/	\N	Legacy Name/Class	t	t
COMT	chr22	NG_011526	NP_000745	\N	\N	HGNC:2228	1312	ENSG00000093010	PA117	\N	PHENOTYPE	89	\N	https://cpicpgx.org/gene/comt/	\N	\N	t	t
CYP2C8	chr10	NG_007972	NP_000761	\N	\N	HGNC:2622	1558	ENSG00000138115	PA125	\N	PHENOTYPE	95	\N	\N	\N	\N	t	t
CYP3A4	chr7	NG_000004	NP_059488	\N	\N	HGNC:2637	1576	ENSG00000160868	PA130	\N	PHENOTYPE	95	\N	\N	\N	\N	t	t
ABCG2	chr4	NG_032067.2	NP_001335914.1	NC_000004.12	NM_004827.3	HGNC:74	9429	ENSG00000118777	PA390	Methods\n\nThe allele frequency table was made by searching the Genome Aggregation Database (gnomAD) and 1000 Genomes phase 3 data by rsID. In addition, pubmed were also searched to include frequencies for certain biogeographical groups (eg. Oceanian and American).\n\nCaveats to estimated allele, frequencies:\n\nSampling. Allele frequencies collected by CPIC for the supplemental tables are based on published literature reports which typically study small groups of people based on a geographic location (e.g. Malaysia, Berlin, Cairo). Almost no studies use genetic markers to estimate ancestry. Manuscripts are often focused on a specific phenotype (e.g. disease) or study only individuals taking a particular drug. Such samples would not be considered a random sample of the general population. Another consideration is that sample size is important, and PGx studies are typically not large. The frequencies collected from these studies are then used to estimate general estimates of entire ethnic population allele frequencies. Therefore, frequencies from larger groups of subjects and frequencies averaged from many sample populations probably result in better estimates.\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details, including the definitions of each group, can be found at https://www.pharmgkb.org/page/biogeographicalGroups. We strongly recommend that users use either the publication or the PharmGKB link provided to familiarize themselves with the grouping system before using these allele frequencies. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.	PHENOTYPE	274	\N	https://cpicpgx.org/gene/abcg2/	\N	\N	t	t
EPHX1	chr1	NG_009776	NP_000111	\N	\N	HGNC:3401	2052	ENSG00000143819	PA27829	\N	PHENOTYPE	95	\N	\N	\N	\N	t	t
GGCX	chr2	NG_011811	NP_000812	\N	\N	HGNC:4247	2677	ENSG00000115486	PA28660	\N	PHENOTYPE	95	\N	\N	\N	\N	t	t
GP1BA	chr17	NG_008767	NP_000164	\N	\N	HGNC:4439	2811	ENSG00000185245	PA178	\N	PHENOTYPE	95	\N	\N	\N	\N	t	t
GSTP1	chr11	NG_012075	NP_000843	\N	\N	HGNC:4638	2950	ENSG00000084207	PA29028	\N	PHENOTYPE	95	\N	\N	\N	\N	t	t
HTR2A	chr13	NG_013011	NP_000612	\N	\N	HGNC:5293	3356	ENSG00000102468	PA193	\N	PHENOTYPE	95	\N	\N	\N	\N	t	t
MTHFR	chr1	NG_013351	NP_005948	\N	\N	HGNC:7436	4524	ENSG00000177000	PA245	\N	PHENOTYPE	95	\N	\N	\N	\N	t	t
NQO1	chr16	NG_011504	NP_000894	\N	\N	HGNC:2874	1728	ENSG00000181019	PA31744	\N	PHENOTYPE	95	\N	\N	\N	\N	t	t
PROC	chr2	NG_016323	NP_000303	\N	\N	HGNC:9451	5624	ENSG00000115718	PA33799	\N	PHENOTYPE	95	\N	\N	\N	\N	t	t
PROS1	chr3	NG_009813	NP_000304	\N	\N	HGNC:9456	5627	ENSG00000184500	PA33809	\N	PHENOTYPE	95	\N	\N	\N	\N	t	t
SCN1A	chr2	NG_011906	NP_008851	\N	\N	HGNC:10585	6323	ENSG00000144285	PA301	\N	PHENOTYPE	95	\N	\N	\N	\N	t	t
SLC6A4	chr17	NG_011747	NP_001036	\N	\N	HGNC:11050	6532	ENSG00000108576	PA312	\N	PHENOTYPE	95	\N	\N	\N	\N	t	t
CYP3A5	chr7	NG_007938.2	NP_000768.1	NC_000007.14	NM_000069.2	HGNC:2638	1577	ENSG00000106258	PA131	Methods\n\nThe allele frequency table was made by searching the PubMed® database (1995 to 2014).\n\nDiplotype and Phenotype Calculations. Diplotype and phenotype frequencies were estimated using the equation describing Hardy Weinberg equilibrium based on reported allele frequencies.\n\nCaveats to estimated allele frequencies:\n\nSampling. Allele frequencies collected by CPIC for the supplemental tables are based on published literature reports which typically study small groups of people based on a geographic location (e.g. Malaysia, Berlin, Cairo). Almost no studies use genetic markers to estimate ancestry. Manuscripts are often focused on a specific phenotype (e.g. disease) or study only individuals taking a particular drug. Such samples would not be considered a random sample of the general population. Another consideration is that sample size is important, and PGx studies are typically not large. The frequencies collected from these studies are then used to estimate general estimates of entire ethnic population allele frequencies. Therefore, frequencies from larger groups of subjects and frequencies averaged from many sample populations probably result in better estimates.\n\nEstimation of *1 frequency. In general, there are no population studies that test for all known variant alleles. Because *1 is not genotyped directly in many studies, all alleles that are negative for a sequence variation are defaulted to a *1 assignment. Because CYP3A5*1 is not genotyped directly, all alleles that are negative for a sequence variation are defaulted to a CYP3A5*1 assignment. Likewise, sequence variations of alleles that are not tested may default to a CYP3A5*1 assignment and hence contribute to the frequencies reported for this allele. Therefore, the inferred frequency for CYP3A5*1 was calculated as an average from studies describing allele frequencies for the most common alleles found in a particular biogeographical group.\n\nDiplotype/Phenotype frequency estimates. Diplotype and phenotype frequencies were estimated using the equation describing Hardy Weinberg equilibrium based on reported allele frequencies. When calculating diplotype frequencies from these allele frequencies, the margin of error is compounded based on the margin of error on each allele in the diplotype. So, the margin of error will necessarily increase for diplotype frequency estimates compared to allele frequency estimates. For allele frequencies with already large margins of error due to small and non-random sampling, the diplotype margin of error could potentially be quite large. On the other hand, for well-studied alleles, the margin of error is likely low.\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details, including the definitions of each group, can be found at https://www.pharmgkb.org/page/biogeographicalGroups. We strongly recommend that users use either the publication or the PharmGKB link provided to familiarize themselves with the grouping system before using these allele frequencies. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.\n	PHENOTYPE	372	\N	https://cpicpgx.org/gene/cyp3a5/	\N	Legacy Name/Class	t	t
CYP2C19	chr10	NG_008384.3	NP_000760.1	NC_000010.11	NM_000069.2	HGNC:2621	1557	ENSG00000165841	PA124	Methods:\nThe CYP2C19 frequency table includes updates of those previously published in CPIC guidelines. Updates to the CYP2C19 frequency tables were made by searching the PubMed® database (1995 to 2015). The following criteria were used for CYP2C19: (CYP2C19 or 2C19 or cytochrome P4502C19) AND (genotype OR allele OR frequency OR minor allele OR variant OR ethnic OR race OR racial OR ethnicity) with filter limits set to retrieve "full-text" and "English" literature. In addition, reports were also identified from citations by others or review articles. Studies were considered for inclusion in the CYP2C19 frequency table if: (1) the ethnicity of the population was clearly indicated, (2) either allele frequencies or genotype frequencies were reported, (3) the method by which the genes were genotyped was indicated, (4) the sample population consisted of at least 50 individuals with a few exceptions (e.g., smaller cohorts that were part of larger studies) and (5) the study represented an original publication (no reviews or meta-analyses). Diplotype and phenotype frequencies were estimated using the equation describing Hardy Weinberg equilibrium based on reported allele frequencies.\n\nDiplotype and Phenotype Calculations. Diplotype and phenotype frequencies were estimated using the equation describing Hardy Weinberg equilibrium based on reported allele frequencies.\n\nCaveats to estimated allele, diplotype and phenotype frequencies:\n\nSampling. Allele frequencies collected by CPIC for the supplemental tables are based on published literature reports which typically study small groups of people based on a geographic location (e.g. Malaysia, Berlin, Cairo). Almost no studies use genetic markers to estimate ancestry. Manuscripts are often focused on a specific phenotype (e.g. disease) or study only individuals taking a particular drug. Such samples would not be considered a random sample of the general population. Another consideration is that sample size is important, and PGx studies are typically not large. The frequencies collected from these studies are then used to estimate general estimates of entire ethnic population allele frequencies. Therefore, frequencies from larger groups of subjects and frequencies averaged from many sample populations probably result in better estimates.\n\nEstimation of *1 frequency. In general, there are no population studies that test for all known variant alleles. Because *1 is not genotyped directly in many studies, all alleles that are negative for a sequence variation are defaulted to a *1 assignment. The inferred frequency for *1 is estimated as: 100 - (sum of averaged variant allele frequencies). For genes where many alleles are not tested for in any population, and frequency of 'common' alleles is not well documented in many understudied populations (Oceanian, Central/South Asian, Latino), the *1 frequency will deviate even more from true values.\n\nDiplotype/Phenotype frequency estimates. Diplotype and phenotype frequencies were estimated using the equation describing Hardy Weinberg equilibrium based on reported allele frequencies. When calculating diplotype frequencies from these allele frequencies, the margin of error is compounded based on the margin of error on each allele in the diplotype. So, the margin of error will necessarily increase for diplotype frequency estimates compared to allele frequency estimates. For allele frequencies with already large margins of error due to small and non-random sampling, the diplotype margin of error could potentially be quite large. On the other hand, for well-studied alleles, the margin of error is likely low.\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details, including the definitions of each group, can be found at https://www.pharmgkb.org/page/biogeographicalGroups. We strongly recommend that users use either the publication or the PharmGKB link provided to familiarize themselves with the grouping system before using these allele frequencies. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.	PHENOTYPE	376	\N	https://cpicpgx.org/gene/cyp2c19/	\N	Legacy Name/Class	t	t
G6PD	chrX	NG_009015.2	NP_000101.2	NC_000023.11	NM_001042351.2	HGNC:4057	2539	ENSG00000160211	PA28469	Methods\n\nThe allele frequency table was made by searching the gnomAD database.\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details can be found at https://www.pharmgkb.org/page/biogeographicalGroups. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n	PHENOTYPE	321	\N	https://cpicpgx.org/gene/g6pd/	\N	Legacy Name/Class	f	f
TPMT	chr6	NG_012137.2	NP_000358.1	NC_000006.12	NM_000540.2	HGNC:12014	7172	ENSG00000137364	PA356	The allele frequency table was made by searching the PubMed® database (no start date to 1/2018). Allele frequencies reported in the gnomAD browser (http://gnomad.broadinstitute.org/ - exomes and genomes) and ensembl (grch37.ensembl.org - exomes or genomes) were also included. URLs are included in the "PMID" column.\n\nDiplotype and Phenotype Calculations. Diplotype and phenotype frequencies were estimated using the equation describing Hardy Weinberg equilibrium based on reported allele frequencies.\n\nCaveats to estimated allele, diplotype and phenotype frequencies:\n\nSampling. Allele frequencies collected by CPIC for the supplemental tables are based on published literature reports which typically study small groups of people based on a geographic location (e.g. Malaysia, Berlin, Cairo). Almost no studies use genetic markers to estimate ancestry. Manuscripts are often focused on a specific phenotype (e.g. disease) or study only individuals taking a particular drug. Such samples would not be considered a random sample of the general population. Another consideration is that sample size is important, and PGx studies are typically not large. The frequencies collected from these studies are then used to estimate general estimates of entire ethnic population allele frequencies. Therefore, frequencies from larger groups of subjects and frequencies averaged from many sample populations probably result in better estimates.\n\nEstimation of *1 frequency. In general, there are no population studies that test for all known variant alleles. Because *1 is not genotyped directly in many studies, all alleles that are negative for a sequence variation are defaulted to a *1 assignment. The inferred frequency for *1 is estimated as: 100 - (sum of averaged variant allele frequencies). For genes where many alleles are not tested for in any population, and frequency of 'common' alleles is not well documented in many understudied populations (Oceania, South Asian, Latino), the *1 frequency will deviate even more from true values.\n\nDiplotype/Phenotype frequency estimates. Diplotype and phenotype frequencies were estimated using the equation describing Hardy Weinberg equilibrium based on reported allele frequencies. When calculating diplotype frequencies from these allele frequencies, the margin of error is compounded based on the margin of error on each allele in the diplotype. So, the margin of error will necessarily increase for diplotype frequency estimates compared to allele frequency estimates. For allele frequencies with already large margins of error due to small and non-random sampling, the diplotype margin of error could potentially be quite large. On the other hand, for well-studied alleles, the margin of error is likely low.\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details can be found at https://www.pharmgkb.org/page/biogeographicalGroups. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.	PHENOTYPE	365	\N	https://cpicpgx.org/gene/tpmt/	\N	Nucleotide change on cDNA from https://liu.se/en/research/tpmt-nomenclature-committee	t	t
IFNL3	chr19	NG_042193.1	NP_000101.2	NC_000019.10	NM_001042351.2	HGNC:18365	282617	ENSG00000197110	PA134952671	\N	ALLELE_STATUS	198	\N	https://cpicpgx.org/gene/ifnl/	\N	Common Name	t	t
CYP2B6	chr19	NG_007929.1	NP_000758.1	NC_000019.10	NM_000069.2	HGNC:2615	1555	ENSG00000197408	PA123	Methods\n\nThe allele frequency table was made by searching the PubMed® database (no start date to May 2018). Studies were considered for inclusion in the CYP2B6 Frequency Table if (1) the ethnicity of the population was clearly indicated; (2) either allele frequencies or genotype frequencies were reported; and (3) the method by which genes were genotyped was indicated. Allele frequencies reported in the gnomAD browser (http://gnomad.broadinstitute.org/ - exomes and genomes) and 1000 Genomes Project phase 3 data on Ensemble browser (https://uswest.ensembl.org/index.html) were also included.\n\nDiplotype and Phenotype Calculations. Diplotype and phenotype frequencies were estimated using the equation describing Hardy Weinberg equilibrium based on reported allele frequencies.\n\nCaveats to estimated allele, diplotype and phenotype frequencies:\n\nSampling. Allele frequencies collected by CPIC for the supplemental tables are based on published literature reports which typically study small groups of people based on a geographic location (e.g. Malaysia, Berlin, Cairo). Almost no studies use genetic markers to estimate ancestry. Manuscripts are often focused on a specific phenotype (e.g. disease) or study only individuals taking a particular drug. Such samples would not be considered a random sample of the general population. Another consideration is that sample size is important, and PGx studies are typically not large. Studies were included in the frequency calculation regardless of number. The frequencies collected from these studies are then used to estimate general estimates of entire ethnic population allele frequencies. Therefore, frequencies from larger groups of subjects and frequencies averaged from many sample populations probably result in better estimates.\n\nEstimation of *1 frequency. In general, there are no population studies that test for all known variant alleles. Because *1 is not genotyped directly in many studies, all alleles that are negative for a sequence variation are defaulted to a *1 assignment. The inferred frequency for *1 is estimated as: 1 - (sum of averaged variant allele frequencies). For genes where many alleles are not tested for in any population, and frequency of 'common' alleles is not well documented in many understudied populations (Oceania, Middle eastern, South Asian, Latino), the *1 frequency will deviate even more from true values.\n\nDiplotype/Phenotype frequency estimates. Diplotype and phenotype frequencies were estimated using the equation describing Hardy Weinberg equilibrium based on reported allele frequencies. When calculating diplotype frequencies from these allele frequencies, the margin of error is compounded based on the margin of error on each allele in the diplotype. So, the margin of error will necessarily increase for diplotype frequency estimates compared to allele frequency estimates. For allele frequencies with already large margins of error due to small and non-random sampling, the diplotype margin of error could potentially be quite large. On the other hand, for well-studied alleles, the margin of error is likely low.\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details, including the definitions of each group, can be found at https://www.pharmgkb.org/page/biogeographicalGroups. We strongly recommend that users use either the publication or the PharmGKB link provided to familiarize themselves with the grouping system before using these allele frequencies. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.	PHENOTYPE	377	\N	https://cpicpgx.org/gene/cyp2b6/	\N	Legacy Name/Class	t	t
CYP4F2	chr19	NG_007971.2	NP_001073.3	NC_000019.10	NM_000069.2	HGNC:2645	8529	ENSG00000186115	PA27121	Methods\n\nThe allele frequency table was made by searching the PubMed® database (1995 to 2016). Allele frequencies reported in and gnomD browser and phase 3 1000 Genomes were also included (https://gnomad.broadinstitute.org/, http://browser.1000genomes.org/index.html) for alleles that contain single unique variant.\n\nCaveats to estimated allele, diplotype and phenotype frequencies:\n\nSampling. Allele frequencies collected by CPIC for the supplemental tables are based on published literature reports which typically study small groups of people based on a geographic location (e.g. Malaysia, Berlin, Cairo). Almost no studies use genetic markers to estimate ancestry. Manuscripts are often focused on a specific phenotype (e.g. disease) or study only individuals taking a particular drug. Such samples would not be considered a random sample of the general population. Another consideration is that sample size is important, and PGx studies are typically not large. The frequencies collected from these studies are then used to estimate general estimates of entire ethnic population allele frequencies. Therefore, frequencies from larger groups of subjects and frequencies averaged from many sample populations probably result in better estimates.\n\nEstimation of *1 frequency. In general, there are no population studies that test for all known variant alleles. Because *1 is not genotyped directly in many studies, all alleles that are negative for a sequence variation are defaulted to a *1 assignment. Because CYP4F2*1 is not genotyped directly, all alleles that are negative for a sequence variation are defaulted to a CYP4F2*1 assignment. Likewise, sequence variations of alleles that are not tested may default to a CYP4F2*1 assignment and hence contribute to the frequencies reported for this allele. Therefore, the inferred frequency for CYP4F2*1 was calculated as an average from studies describing allele frequencies for the most common alleles found in a particular biogeographical group.\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details can be found at https://www.pharmgkb.org/page/biogeographicalGroups. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.	PHENOTYPE	294	CYP4F2 diplotype to phenotype translation is not applicable to the warfarin guideline.	https://cpicpgx.org/gene/cyp4f2/	\N	Legacy Name/Class	f	f
CACNA1S	chr1	NG_009816.1	NP_000060.2	NC_000001.11	NM_000069.2	HGNC:1397	779	ENSG00000081248	PA85	Methods\n\nThe allele frequency table was made by searching the Genome Aggregation Database (gnomAD) by each rsID\n\nCaveats to estimated allele, frequencies:\n\nSampling. Allele frequencies collected by CPIC for the supplemental tables are based on published literature reports which typically study small groups of people based on a geographic location (e.g. Malaysia, Berlin, Cairo). Almost no studies use genetic markers to estimate ancestry. Manuscripts are often focused on a specific phenotype (e.g. disease) or study only individuals taking a particular drug. Such samples would not be considered a random sample of the general population. Another consideration is that sample size is important, and PGx studies are typically not large. The frequencies collected from these studies are then used to estimate general estimates of entire ethnic population allele frequencies. Therefore, frequencies from larger groups of subjects and frequencies averaged from many sample populations probably result in better estimates.\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details, including the definitions of each group, can be found at https://www.pharmgkb.org/page/biogeographicalGroups. We strongly recommend that users use either the publication or the PharmGKB link provided to familiarize themselves with the grouping system before using these allele frequencies. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.	PHENOTYPE	378	\N	https://cpicpgx.org/gene/cacna1s/	\N	\N	f	f
VKORC1	chr16	NG_011564.1	NP_076869.1	NC_000016.10	NM_000540.2	HGNC:23663	79001	ENSG00000167397	PA133787052	Methods\n\nThe allele frequency table was made by searching the PubMed® database (1995 to 2016). Allele frequencies reported in phase 3 1000 Genomes were also included (http://browser.1000genomes.org/index.html).\n\nCaveats to estimated allele, diplotype and phenotype frequencies:\n\nSampling. Allele frequencies collected by CPIC for the supplemental tables are based on published literature reports which typically study small groups of people based on a geographic location (e.g. Malaysia, Berlin, Cairo). Almost no studies use genetic markers to estimate ancestry. Manuscripts are often focused on a specific phenotype (e.g. disease) or study only individuals taking a particular drug. Such samples would not be considered a random sample of the general population. Another consideration is that sample size is important, and PGx studies are typically not large. The frequencies collected from these studies are then used to estimate general estimates of entire ethnic population allele frequencies. Therefore, frequencies from larger groups of subjects and frequencies averaged from many sample populations probably result in better estimates.\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details can be found at https://www.pharmgkb.org/page/biogeographicalGroups. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.	PHENOTYPE	289	VKORC1 diplotype to phenotype translation is not applicable to the warfarin guideline.	https://cpicpgx.org/gene/vkorc1/	\N	Common Name	f	f
SLCO1B1	chr12	NG_011745.1	NP_006437.3	NC_000012.12	NM_000540.2	HGNC:10959	10599	ENSG00000134538	PA134865839	Methods\n\nThe allele frequency table was made by searching the PubMed® database (1995 to 2021).\n\nCaveats to estimated allele frequencies:\n\nSampling. Allele frequencies collected by CPIC for the supplemental tables are based on published literature reports which typically study small groups of people based on a geographic location (e.g. Malaysia, Berlin, Cairo). Almost no studies use genetic markers to estimate ancestry. Manuscripts are often focused on a specific phenotype (e.g. disease) or study only individuals taking a particular drug. Such samples would not be considered a random sample of the general population. Another consideration is that sample size is important, and PGx studies are typically not large. The frequencies collected from these studies are then used to estimate general estimates of entire ethnic population allele frequencies. Therefore, frequencies from larger groups of subjects and frequencies averaged from many sample populations probably result in better estimates.\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details can be found at https://www.pharmgkb.org/page/biogeographicalGroups. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.	PHENOTYPE	365	\N	https://cpicpgx.org/gene/slco1b1/	\N	Common name	t	t
UGT1A1	chr2	NG_002601.2	NP_000454.1	NC_000002.12	NM_000540.2	HGNC:12530	54658	ENSG00000241635	PA420	Methods\n\nThe allele frequency table was made by searching the PubMed® database (1995 to 2015). Allele frequencies reported in phase 3 1000 Genomes were also included (http://browser.1000genomes.org/index.html).\n\nCaveats to estimated allele, diplotype and phenotype frequencies:\n\nSampling. Allele frequencies collected by CPIC for the supplemental tables are based on published literature reports which typically study small groups of people based on a geographic location (e.g. Malaysia, Berlin, Cairo). Almost no studies use genetic markers to estimate ancestry. Manuscripts are often focused on a specific phenotype (e.g. disease) or study only individuals taking a particular drug. Such samples would not be considered a random sample of the general population. Another consideration is that sample size is important, and PGx studies are typically not large. The frequencies collected from these studies are then used to estimate general estimates of entire ethnic population allele frequencies. Therefore, frequencies from larger groups of subjects and frequencies averaged from many sample populations probably result in better estimates.\n\nEstimation of *1 frequency. In general, there are no population studies that test for all known variant alleles. Because *1 is not genotyped directly in many studies, all alleles that are negative for a sequence variation are defaulted to a *1 assignment. Because UGT1A1*1 is not genotyped directly, all alleles that are negative for a sequence variation are defaulted to a UGT1A1*1 assignment. Likewise, sequence variations of alleles that are not tested may default to a UGT1A1*1 assignment and hence contribute to the frequencies reported for this allele. Therefore, the inferred frequency for UGT1A1*1 was calculated as an average from studies describing allele frequencies for the most common alleles found in a particular biogeographical group.\n\nBiogeographical groups. Biogeographical groups are derived from PMID 30506572. Further details can be found at https://www.pharmgkb.org/page/biogeographicalGroups. These tables group individuals from particular geographic locations into larger biogeographical groups. It is difficult to group populations with certainty, because some populations are often admixed, or at the least, a combination of different ethnicities. Therefore, the margin of error is increased when different subpopulations are grouped together.	PHENOTYPE	367	\N	https://cpicpgx.org/gene/ugt1a1/	\N	Nucleotide changes from the UGT nomenclature page: https://www.pharmacogenomics.pha.ulaval.ca/wp-content/uploads/2015/04/UGT1A1-allele-nomenclature.html	f	f
\.


--
-- Data for Name: gene_result; Type: TABLE DATA; Schema: cpic; Owner: -
--

COPY cpic.gene_result (id, genesymbol, result, activityscore, ehrpriority, consultationtext, version, frequency) FROM stdin;
5985578	TPMT	Intermediate Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a normal function allele and one copy of a no function allele. Based on the genotype result this patient is predicted to be a TPMT intermediate metabolizer. This patient may be at risk for an adverse reactions to medications that are metabolized by TPMT (eg. thiopurines). To avoid an untoward drug response, dose adjustments or alternative therapeutic agents may be necessary for medications metabolized by TPMT. However, thiopurines can be affected by a patient's TPMT and NUDT15 phenotype. Please consult a clinical pharmacist for more information about how TPMT and NUDT15 metabolic status influences drug selection and dosing.	3	{"Latino": 0.100754894, "European": 0.083957225, "East Asian": 0.033404876, "Near Eastern": 0.06641302, "Central/South Asian": 0.034146916, "Sub-Saharan African": 0.1004582, "African American/Afro-Caribbean": 0.068898946}
5985591	TPMT	Poor Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has two copies of a no function allele. Based on the genotype result this patient is predicted to be a TPMT poor metabolizer. This patient may be at a high risk for an adverse reactions to medications that are metabolized by TPMT (eg. thiopurines). To avoid an untoward drug response, dose adjustments or or alternative therapy may be necessary for medications metabolized by TPMT. However, thiopurines can be affected by a patient's TPMT and NUDT15 phenotype. Please consult a clinical pharmacist for more information about how TPMT and NUDT16 metabolic status influences drug selection and dosing.	3	{"Latino": 0.0028512129, "European": 0.0019385515, "East Asian": 0.00029069668, "Near Eastern": 0.0011826118, "Central/South Asian": 0.00030267553, "Sub-Saharan African": 0.002971174, "African American/Afro-Caribbean": 0.0013917874}
5958216	RYR1	Malignant Hyperthermia Susceptibility	n/a	Abnormal/Priority/High Risk	This result signifies that this patient has one copy of a variant [variant] associated with malignant hyperthermia susceptibility. Halogenated volatile anesthetics or depolarizing muscle relaxants are relatively contraindicated in persons with MHS. They should not be used, except in extraordinary circumstances where the benefits outweigh the risks. Please consult a MHS specialist or contact MHAUS (https://www.mhaus.org/healthcare-professionals/) for further information.	2	\N
5886419	CYP2C19	Ultrarapid Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has two copies of an increased function allele. Based on the genotype result this patient is predicted to be an ultrarapid metabolizer of CYP2C19 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2C19. To avoid an untoward drug response, dose adjustments or alternative therapeutic agents may be necessary for medications metabolized by CYP2C19. Please consult a clinical pharmacist for more information about how CYP2C19 metabolic status influences drug selection and dosing.	3	{"Latino": 0.02774172, "American": 0.0074097984, "European": 0.04641379, "Oceanian": 0.003249, "East Asian": 0.00042194634, "Near Eastern": 0.036642652, "Central/South Asian": 0.029163336, "Sub-Saharan African": 0.030045323, "African American/Afro-Caribbean": 0.042943195}
5886422	CYP2C19	Rapid Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a normal function allele and one copy of an increased function allele. Based on the genotype result this patient is predicted to be a rapid metabolizer of CYP2C19 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2C19. To avoid an untoward drug response, dose adjustments or alternative therapeutic agents may be necessary for medications metabolized by CYP2C19. Please consult a clinical pharmacist for more information about how CYP2C19 metabolic status influences drug selection and dosing.	3	{"Latino": 0.24136075, "American": 0.13638271, "European": 0.2711846, "Oceanian": 0.021329276, "East Asian": 0.025343522, "Near Eastern": 0.2573682, "Central/South Asian": 0.18567303, "Sub-Saharan African": 0.21080859, "African American/Afro-Caribbean": 0.2373838}
5926546	NUDT15	Indeterminate	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has an allele combination with uncertain and/or unknown function alleles. The expected phenotype for this patient cannot be determined currently based on the NUDT15 diplotype result. If thiopurines are required and NUDT15 status is unknown, monitor closely for toxicity. Please consult a clinical pharmacist for more specific information about how NUDT15 function influences drug dosing.	3	{"Latino": 0.03663146, "European": 0.006048766, "East Asian": 0.045933217, "Central/South Asian": 0.0046207304}
5985688	TPMT	Possible Intermediate Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of an uncertain/unknown function allele and one copy of a no function allele. Based on the genotype result this patient has a priority result (TPMT possible intermediate metabolizer) because their activity is not likely to be any higher than that of an intermediate metabolizer; if the uncertain/unknown function allele is also low, activity may be even lower than that of an intermediate metabolizer. This patient may be at risk for an adverse reactions to medications that are metabolized by TPMT (eg. thiopurines). To avoid an untoward drug response, dose adjustments or alternative therapeutic agents may be necessary for medications metabolized by TPMT. However, thiopurines can be affected by a patient's TPMT and NUDT15 phenotype. Please consult a clinical pharmacist for more information about how TPMT and NUDT15metabolic status influences drug selection and dosing.	3	{"Latino": 0.00033617634, "European": 0.0002236386, "East Asian": 0.000113386974, "Near Eastern": 0.0, "Central/South Asian": 0.000042878622, "Sub-Saharan African": 0.0026164071, "African American/Afro-Caribbean": 0.0029308118}
5984595	SLCO1B1	Indeterminate	n/a	none	This result signifies that the patient has an allele combination with unknown or uncertain function alleles. The expected phenotype for this patient cannot be determined currently based on the SLCO1B1 diplotype result. Please consult a clinical pharmacist for more specific information about how SLCO1B1 function influences drug dosing.	3	{"American": 0.0, "European": 0.0014452906, "Oceanian": 0.0, "East Asian": 0.007855513, "Near Eastern": 0.0, "Central/South Asian": 0.0005580649, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": 0.0}
5886431	CYP2C19	Normal Metabolizer	n/a	Normal/Routine/Low Risk	This result signifies that the patient has two copies of a normal function allele. Based on the genotype result this patient is predicted to be an normal metabolizer of CYP2C19 substrates. There is no reason to selectively adjust the dose of most medications that are metabolized by CYP2C19. Please consult a clinical pharmacist for more information about how CYP2C19 metabolic status influences drug selection and dosing.	3	{"Latino": 0.5249766, "American": 0.62755567, "European": 0.39611652, "Oceanian": 0.035006005, "East Asian": 0.38055435, "Near Eastern": 0.45192146, "Central/South Asian": 0.29552925, "Sub-Saharan African": 0.36977687, "African American/Afro-Caribbean": 0.32805592}
5984564	SLCO1B1	Increased Function	n/a	Normal/Routine/Low Risk	This result signifies that the patient has two copies of an increased function allele. Based on the genotype result, this patient is predicted to have increased SLCO1B1 function. This means that there is no reason to adjust the dose of most medications that are affected by SLCO1B1 on the basis of SLCO1B1 genetic status at this time. Please consult a clinical pharmacist for more specific information about how SLCO1B1 function influences drug dosing.	3	{"American": 0.0, "European": 0.029916462, "Oceanian": 0.0, "East Asian": 0.0, "Near Eastern": 0.0, "Central/South Asian": 0.0, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": 0.0}
5984569	SLCO1B1	Decreased Function	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a normal function allele (*_) and one copy of a no function allele (*_). Based on the genotype result, this patient is predicted to have decreased SLCO1B1 function. This patient may be at risk for an adverse response to medications that are affected by SLCO1B1. To avoid an untoward drug response, dose adjustments may be necessary for medications affected by SLCO1B1 (i.e. statins). Please consult a clinical pharmacist for more specific information about how SLCO1B1 function influences drug dosing.	3	{"American": 0.3648, "European": 0.28279552, "Oceanian": 0.0, "East Asian": 0.21842287, "Near Eastern": 0.32000002, "Central/South Asian": 0.12971397, "Sub-Saharan African": 0.054308295, "African American/Afro-Caribbean": 0.0198}
5984589	SLCO1B1	Normal Function	n/a	Normal/Routine/Low Risk	This result signifies that the patient has two copies of a normal function allele. Based on the genotype result, this patient is predicted to have normal SLCO1B1 function. This means that there is no reason to adjust the dose of most medications that are affected by SLCO1B1 on the basis of SLCO1B1 genetic status. Please consult a clinical pharmacist for more specific information about how SLCO1B1 function influences drug dosing.	3	{"American": 0.5776, "European": 0.6564144, "Oceanian": 1.0, "East Asian": 0.75683165, "Near Eastern": 0.64000005, "Central/South Asian": 0.8648222, "Sub-Saharan African": 0.94491136, "African American/Afro-Caribbean": 0.98010004}
5905129	DPYD	Normal Metabolizer	2.0	Normal/Routine/Low Risk	This result signifies that the patient has two copies of normal function DPYD alleles. Based on the genotype result this patient is predicted to be DPYD Normal Metabolizer with a DPYD activity score of 2. For this genotype, no selective dose adjustment is indicated for medications that are metabolized by DPD. Please consult a clinical pharmacist for more information about how DPD metabolic status influences drug selection and dosing.	2	\N
5984660	SLCO1B1	Poor Function	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has two copies of a no function allele. Based on the genotype result, this patient is predicted to have low SLCO1B1 function. This patient may be at a high risk for an adverse response to medications that are affected by SLCO1B1 (i.e. statins). To avoid an untoward drug response, dose adjustments or alternative therapeutic agents may be necessary for medications affected by SLCO1B1. Please consult a clinical pharmacist for more specific information about how SLCO1B1 function influences drug dosing.	3	{"American": 0.0576, "European": 0.029130744, "Oceanian": 0.0, "East Asian": 0.015759302, "Near Eastern": 0.040000003, "Central/South Asian": 0.004863923, "Sub-Saharan African": 0.0007803353, "African American/Afro-Caribbean": 0.00010}
5984730	SLCO1B1	Possible Decreased Function	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a uncertain or unknown function allele (*_) and one copy of a no function allele (*_). Based on the genotype result, this patient is predicted to have possible decreased SLCO1B1 function. This patient may be at risk for an adverse response to medications that are affected by SLCO1B1. To avoid an untoward drug response, dose adjustments may be necessary for medications affected by SLCO1B1 (i.e. statins). Please consult a clinical pharmacist for more specific information about how SLCO1B1 function influences drug dosing.	3	{"American": 0.0, "European": 0.00029760195, "Oceanian": 0.0, "East Asian": 0.0011306308, "Near Eastern": 0.0, "Central/South Asian": 0.0000418451, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": 0.0}
5985575	TPMT	Normal Metabolizer	n/a	Normal/Routine/Low Risk	This result signifies that the patient has two copies of a normal function allele. Based on the genotype result this patient is predicted to be a TPMT normal metabolizer. There is no reason to selectively adjust the dose of most medications that are metabolized by TPMT. However, thiopurines can be affected by a patient's TPMT and NUDT15 phenotype. Please consult a clinical pharmacist for more information about how TPMT and NUDT15 metabolic status influences drug selection and dosing.	3	{"Latino": 0.890108, "European": 0.9090313, "East Asian": 0.9596651, "Near Eastern": 0.93240434, "Central/South Asian": 0.96308726, "Sub-Saharan African": 0.8491466, "African American/Afro-Caribbean": 0.8526922}
5985659	TPMT	Indeterminate	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has an allele combination with uncertain and/or unknown function alleles. The expected phenotype for this patient cannot be determined currently based on the TPMT diplotype result. Consider evaluating TPMT erythrocyte activity to assess TPMT phenotype. Erythrocyte TPMT activity test results can be falsely low at diagnosis of leukemia and is unreliable in the case of recent red blood cell transfusions. If thiopurines are required and TPMT status is unknown, monitor closely for toxicity. Please consult a clinical pharmacist for more specific information about how TPMT function influences drug dosing.	3	{"Latino": 0.0059497347, "European": 0.0048492607, "East Asian": 0.006525885, "Near Eastern": 0.0, "Central/South Asian": 0.0024202352, "Sub-Saharan African": 0.044807594, "African American/Afro-Caribbean": 0.07408627}
5986536	UGT1A1	Normal Metabolizer	n/a	Normal/Routine/Low Risk	This result signifies that the patient has two copies of a normal function allele (*1) OR one copy of a normal function allele (*1) and one copy of an increased function allele (*36) OR two copies of an increased function allele (*36). Based on the genotype result this patient is predicted to be an normal metabolizer of UGT1A1 substrates. There is no reason to selectively adjust the dose of most medications that inhibit or are inactivated by UGT1A1. Please consult a clinical pharmacist for more information about how UGT1A1 metabolic status influences drug selection and dosing.	2	\N
5986543	UGT1A1	Intermediate Metabolizer	n/a	Normal/Routine/Low Risk	This result signifies that the patient has one copy of a normal function allele (*1) OR one copy of an increased function allele (*36), AND and one copy of a decreased function allele (*_). Based on the genotype result this patient is predicted to be an intermediate metabolizer of UGT1A1 substrates. There is no reason to selectively adjust the dose of most medications that inhibit or are inactivated by UGT1A1. Please consult a clinical pharmacist for more information about how UGT1A1 metabolic status influences drug selection and dosing.	2	\N
5986558	UGT1A1	Poor Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has two copies of decreased function alleles (*_ and *_). Based on the genotype result this patient is predicted to be a poor metabolizer of UGT1A1 substrates. This patient may be at risk for an adverse or poor response to medications that inhibit or are inactivated by UGT1A1. Based on the genotype result, this patient is predicted to have low UGT1A1 function, which is generally indicative of Gilbert syndrome. This patient may be at high risk for toxicity from select medications that inhibit or are inactivated by UGT1A1. Please consult a clinical pharmacist for more information about how UGT1A1 metabolic status influences drug selection and dosing.	2	\N
5986581	UGT1A1	Indeterminate	n/a	none	This result signifies that the patient has an allele combination with uncertain and/or unknown function alleles. The expected phenotype for this patient cannot be determined currently based on the UGT1A1 diplotype result. UGT1A1*80 is in very high linkage disequilibrium with *28 and *37. In the rare event that *80 is detected but *28 and *37 are not, there are not enough clinical data to predict metabolizer status with certainty. However, if only *80 is interrogated and the patient is heterozygous or homozygous for *80, an intermediate or poor metabolizer phenotype may be inferred, respectively. Please consult a clinical pharmacist for more specific information about how UGT1A1 function influences drug dosing.	2	\N
5890596	CYP2D6	Normal Metabolizer	1.75	Normal/Routine/ Low Risk	This result signifies that this patient has three copies of *41 (*41x3) and one copy of a normal function allele (*_) or [2 copies of a decreased function allele with an activity value of 0.5 (*_x2)]. Based on the genotype result this patient is predicted to be a normal metabolizer of CYP2D6 substrates. There is no reason to selectively adjust the dose of most medications that are metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.0, "American": 0.0, "European": 0.0, "Oceanian": 0.0, "East Asian": 0.0, "Near Eastern": 0.0, "Central/South Asian": 0.0, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": 0.0}
5890593	CYP2D6	Normal Metabolizer	1.5	Normal/Routine/ Low Risk	This result signifies that this patient has [1 copy of a normal function allele (*_)] [X copies of a decreased function allele (*_)] [X copies of a no function allele (*_)]. Based on the genotype result this patient is predicted to be a normal metabolizer of CYP2D6 substrates. There is no reason to selectively adjust the dose of most medications that are metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.051568672, "American": 0.012521543, "European": 0.010339902, "Oceanian": 0.00143701, "East Asian": 0.017062929, "Near Eastern": 0.045171212, "Central/South Asian": 0.0029989334, "Sub-Saharan African": 0.23161727, "African American/Afro-Caribbean": 0.23827769}
5986595	HLA-A	*31:01 negative	n/a	Routine/Low-Risk	The HLA-A*31:01 allele, which is associated with severe cutaneous adverse reactions among patients taking certain aromatic anticonvulsants, was not detected in this patient. No change in therapy is warranted based on these results. It should be noted that a negative HLA-A*31:01 result does not absolutely rule out the possibility of an adverse drug reaction. Please consult a clinical pharmacist for more information.	1	\N
5986598	HLA-A	*31:01 positive	n/a	Priority/High-Risk	This result signifies that the patient has one or two copies of HLA-A*31:01. Patients with this genotype are at increased risk of severe cutaneous adverse reactions, including Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN), drug reaction with eosinophilia and systemic symptoms (DRESS), and maculopapular exanthema (MPE), with certain aromatic anticonvulsants (e.g., carbamazepine). Alternative therapy may be warranted. Please consult a clinical pharmacist for more information.	1	\N
5886461	CYP2C19	Likely Intermediate Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a normal function allele and one copy of a decreased function allele OR one copy of an increased function allele and one copy of a decreased function allele OR two copies of a decreased function allele. Based on the genotype result this patient MAY be an intermediate metabolizer of CYP2C19 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2C19. To avoid an untoward drug response, dose adjustments or alternative therapeutic agents may be necessary for medications metabolized by CYP2C19. Please consult a clinical pharmacist for more information about how CYP2C19 metabolic status influences drug selection and dosing.	3	{"Latino": 0.003709162, "American": 0.0, "European": 0.0011160374, "Oceanian": 0.0, "East Asian": 0.00076989824, "Near Eastern": 0.0, "Central/South Asian": 0.0, "Sub-Saharan African": 0.042863965, "African American/Afro-Caribbean": 0.027788177}
5886534	CYP2C19	Intermediate Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a normal function allele and one copy of a no function allele OR one copy of an increased function and one copy of a no function allele. Based on the genotype result this patient is predicted to be an intermediate metabolizer of CYP2C19 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2C19. To avoid an untoward drug response, dose adjustments or alternative therapeutic agents may be necessary for medications metabolized by CYP2C19. Please consult a clinical pharmacist for more information about how CYP2C19 metabolic status influences drug selection and dosing.	3	{"Latino": 0.19035932, "American": 0.21383229, "European": 0.26108757, "Oceanian": 0.36902928, "East Asian": 0.45928204, "Near Eastern": 0.2354828, "Central/South Asian": 0.40806636, "Sub-Saharan African": 0.29945874, "African American/Afro-Caribbean": 0.31398684}
5889984	CYP2D6	Ultrarapid Metabolizer	≥5.0	Abnormal/Priority/High Risk	This result signifies that this patient has [X copies of a normal function allele (*_xN)] [X copies of a decreased function allele (*_)] [X copies of a no function allele (*_)]. Based on the genotype result this patient is predicted to be an ultrarapid metabolizer of CYP2D6 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2D6. To avoid an untoward drug response, dose adjustments may be necessary for medications metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.000055729302, "American": 0.00006450697, "European": 0.000058472542, "Oceanian": 0.0, "East Asian": 0.000015887783, "Near Eastern": 0.0, "Central/South Asian": 0.0, "Sub-Saharan African": 0.00025361063, "African American/Afro-Caribbean": 0.0}
5890000	CYP2D6	Ultrarapid Metabolizer	≥4.0	Abnormal/Priority/High Risk	This result signifies that this patient has [X copies of a normal function allele (*_xN)] [X copies of a decreased function allele (*_)] [X copies of a no function allele (*_)]. Based on the genotype result this patient is predicted to be an ultrarapid metabolizer of CYP2D6 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2D6. To avoid an untoward drug response, dose adjustments may be necessary for medications metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.0012809848, "American": 0.0015109289, "European": 0.0018874556, "Oceanian": 0.0, "East Asian": 0.0007779561, "Near Eastern": 0.0, "Central/South Asian": 0.0, "Sub-Saharan African": 0.0038317435, "African American/Afro-Caribbean": 0.0}
5986601	HLA-B	*15:02 negative	n/a	Routine/Low-Risk	The HLA-B*15:02 allele, which is associated with severe cutaneous adverse reactions among patients taking certain aromatic anticonvulsants, was not detected in this patient. No change in therapy is warranted based on these results. It should be noted that a negative HLA-B*15:02 result does not absolutely rule out the possibility of an adverse drug reaction. Please consult a clinical pharmacist for more information.	1	\N
5986604	HLA-B	*15:02 positive	n/a	Priority/High-Risk	This result signifies that the patient has one or two copies of HLA-B*15:02. Patients with this genotype are at increased risk of severe cutaneous adverse reactions, including Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN), with certain aromatic anticonvulsants (e.g., carbamazepine, oxcarbazepine, phenytoin/fosphenytoin). Alternative therapy may be warranted. Please consult a clinical pharmacist for more information.	1	\N
5986607	HLA-B	*57:01 negative	n/a	Normal/Routine/Low Risk	The HLA-B*57:01 allele, associated with abacavir hypersensitivity, was not detected in this patient. The patient may be prescribed abacavir. Please refer to the hospital formulary guidelines for specific dosing information. It should be noted that a negative HLA-B*57:01 result does not absolutely rule out the possibility of some form of abacavir hypersensitivity. Administration of abacavir therapy requires close observation including immediate discontinuation of therapy should any signs or symptoms of hypersensitivity develop.	1	\N
5986610	HLA-B	*57:01 positive	n/a	Abnormal/Priority/High Risk	The HLA-B*57:01 allele, associated with abacavir hypersensitivity, was detected in this patient. HLA-B*5701 positive patients should NOT be prescribed abacavir.	1	\N
5986613	HLA-B	*58:01 negative	n/a	Normal/Routine/Low Risk	The HLA-B*58:01 allele, associated with allopurinol hypersensitivity, was not detected in this patient. Allopurinol can be used per standard dosing guidelines. Patients should be monitored closely for any signs of sensitivity reactions, especially those patients receiving allopurinol (of >300 mg/day), concomitant medications (i.e. thiazide diuretics or penicillin/cephalosporin) or with medical conditions (i.e. chronic kidney disease) that increase the non-genetic risk for allopurinol-related hypersensitivity reactions.	1	\N
5986616	HLA-B	*58:01 positive	n/a	Abnormal/Priority/High Risk	The HLA-B*58:01 allele, associated with allopurinol hypersensitivity, was detected in this patient. Allopurinol is contraindicated.	1	\N
5886787	CYP2C19	Indeterminate	n/a	none	This result signifies that the patient has an allele combination with uncertain and/or unknown function alleles. The expected phenotype for this patient cannot be determined currently based on the CYP2C19 diplotype result. Please consult a clinical pharmacist for more specific information about how CYP2C19 function influences drug dosing.	3	{"Latino": 0.0, "American": 0.0, "European": 0.0, "Oceanian": 0.0, "East Asian": 0.0034064606, "Near Eastern": 0.0, "Central/South Asian": 0.0, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": 0.0022393465}
5887108	CYP2C9	Normal Metabolizer	2.0	Normal/Routine/Low Risk	This result signifies that the patient has two copies of a normal function allele. Based on the genotype result, this patient is predicted to be a CYP2C9 Normal metabolizer. Based only on the CYP2C9 genotype, there is no reason to adjust the dose of most medications that are affected by CYP2C9. Please consult a clinical pharmacist for more specific information about how CYP2C9 function influences drug dosing.	3	{"Latino": 0.74342215, "American": 0.83149743, "European": 0.62845254, "Oceanian": 0.9122409, "East Asian": 0.8378542, "Near Eastern": 0.61125296, "Central/South Asian": 0.5961676, "Sub-Saharan African": 0.73114437, "African American/Afro-Caribbean": 0.75866354}
5926533	NUDT15	Intermediate Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a normal function allele and one copy of a no function allele. Based on the genotype result this patient is predicted to be a NUDT15 intermediate metabolizer. This patient may be at risk for an adverse reactions to medications that are metabolized by NUDT15 (eg thiopurines). To avoid an untoward drug response, dose adjustments or alternative therapeutic agents may be necessary for medications metabolized by NUDT15. Please consult a clinical pharmacist for more information about how NUDT15 metabolic status influences drug selection and dosing.	3	{"Latino": 0.082887314, "European": 0.0076054693, "East Asian": 0.16783968, "Central/South Asian": 0.12554385}
5926553	NUDT15	Possible Intermediate Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of an uncertain function allele and one copy of a no function allele. Based on the genotype result this patient is predicted to be a NUDT15 possible intermediate metabolizer. This patient may be at risk for an adverse reactions to medications that are metabolized by NUDT15 (eg thiopurines). To avoid an untoward drug response, dose adjustments or alternative therapeutic agents may be necessary for medications metabolized by NUDT15. Please consult a clinical pharmacist for more information about how NUDT15 metabolic status influences drug selection and dosing.	3	{"Latino": 0.0017137243, "European": 0.000023285522, "East Asian": 0.0049198293, "Central/South Asian": 0.00033489507}
5884377	ABCG2	Poor Function	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has two copies of a decreased function allele. Based on the genotype result, this patient is predicted to have poor ABCG2 function. This patient may be at a high risk for an adverse response to medications that are affected by ABCG2 (i.e. statins). To avoid an untoward drug response, dose adjustments or alternative therapeutic agents may be necessary for medications affected by ABCG2. Please consult a clinical pharmacist for more specific information about how ABCG2 function influences drug dosing.	3	{"Latino": 0.05035536, "American": 0.040000003, "European": 0.010732961, "Oceanian": 0.0419122, "East Asian": 0.09431041, "Near Eastern": 0.00426409, "Central/South Asian": 0.00868624, "Sub-Saharan African": 0.000034175762, "African American/Afro-Caribbean": 0.0012156549}
5884380	ABCG2	Decreased Function	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a normal function allele and one copy of a no decreased allele . Based on the genotype result, this patient is predicted to have decreased ABCG2 function. This patient may be at risk for an adverse response to medications that are affected by ABCG2. To avoid an untoward drug response, dose adjustments may be necessary for medications affected by ABCG2 (i.e. statins). Please consult a clinical pharmacist for more specific information about how ABCG2 function influences drug dosing.	3	{"Latino": 0.34808928, "American": 0.32000002, "European": 0.18573408, "Oceanian": 0.32562497, "East Asian": 0.4255792, "Near Eastern": 0.122071825, "Central/South Asian": 0.1690275, "Sub-Saharan African": 0.011623656, "African American/Afro-Caribbean": 0.06730118}
5884386	CACNA1S	Malignant Hyperthermia Susceptibility	n/a	Abnormal/Priority/High Risk	This result signifies that this patient has one copy of a variant [variant] associated with malignant hyperthermia susceptibility. Halogenated volatile anesthetics or depolarizing muscle relaxants are relatively contraindicated in persons with MHS. They should not be used, except in extraordinary circumstances where the benefits outweigh the risks. Please consult a MHS specialist or contact MHAUS (https://www.mhaus.org/healthcare-professionals/) for further information.	2	\N
5884394	CACNA1S	Uncertain Susceptibility	n/a	Normal Risk	Variation in RYR1 and/or CACNA1S genes is associated with increased risk of Malignant hyperthermia after administration of depolarizing muscle relaxants and potent volatile anesthetics. Although listed causative CACNA1S variants were NOT detected in this patient, it should be noted that this finding does not absolutely rule out the possibility of malignant hyperthermia. These results should be interpreted in the context of other genetic and clinical findings, family history and other laboratory data.	2	\N
5926586	RYR1	Uncertain Susceptibility	n/a	Normal Risk	Variation in RYR1 and/or CACNA1S genes is associated with increased risk of Malignant hyperthermia after administration of depolarizing muscle relaxants and potent volatile anesthetics. Although listed causative RYR1 variants were NOT detected in this patient, it should be noted that this finding does not absolutely rule out the possibility of malignant hyperthermia. These results should be interpreted in the context of other genetic and clinical findings, family history and other laboratory data.	2	\N
5887113	CYP2C9	Intermediate Metabolizer	1.5	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a normal function allele and one copy of a decreased function allele. Based on the genotype result, this patient is predicted to be a CYP2C9 intermediate metabolizer (activity score of 1.5). This patient may be at risk for an adverse response to medications that are affected by CYP2C9. Please consult a clinical pharmacist for more specific information about how CYP2C9 intermediate metabolizer status influences drug dosing.	3	{"Latino": 0.1647683, "American": 0.10592343, "European": 0.20758142, "Oceanian": 0.05599055, "East Asian": 0.052658077, "Near Eastern": 0.2097067, "Central/South Asian": 0.17885593, "Sub-Saharan African": 0.21372117, "African American/Afro-Caribbean": 0.1863267}
5887157	CYP2C9	Intermediate Metabolizer	1.0	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a normal function allele and one copy of a no function allele OR two copies of decreased function alleles. Based on the genotype result, this patient is predicted to be a CYP2C9 intermediate metabolizer (activity score of 1). This patient may be at risk for an adverse response to medications that are affected by CYP2C9. Please consult a clinical pharmacist for more specific information about how CYP2C9 intermediate metabolizer status influences drug dosing.	3	{"Latino": 0.08109343, "American": 0.05818467, "European": 0.13767911, "Oceanian": 0.03061276, "East Asian": 0.098925985, "Near Eastern": 0.1494271, "Central/South Asian": 0.18352722, "Sub-Saharan African": 0.049747862, "African American/Afro-Caribbean": 0.049812526}
5884383	ABCG2	Normal Function	n/a	Normal/Routine/Low Risk	This result signifies that the patient has two copies of a normal function allele. Based on the genotype result, this patient is predicted to have normal ABCG2 function. This means that there is no reason to adjust the dose of most medications that are affected by ABCG2 on the basis of ABCG2 genetic status. Please consult a clinical pharmacist for more specific information about how ABCG2 function influences drug dosing.	3	{"Latino": 0.6015554, "American": 0.64000005, "European": 0.8035329, "Oceanian": 0.63246274, "East Asian": 0.4801104, "Near Eastern": 0.87366414, "Central/South Asian": 0.8222862, "Sub-Saharan African": 0.9883421, "African American/Afro-Caribbean": 0.9314832}
5885256	CYP2B6	Intermediate Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a normal function allele and one copy of a no function allele OR one copy of a normal function allele and one copy of a decreased function allele OR one copy of an increased function allele and one copy of a no function allele OR one copy of an increased function allele and one copy of a decreased function allele. Based on the genotype result this patient is predicted to be an intermediate metabolizer of CYP2B6 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2B6. To avoid an untoward drug response, dose adjustments or alternative therapeutic agents may be necessary for medications metabolized by CYP2B6. Please consult a clinical pharmacist for more information about how CYP2B6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.42165288, "European": 0.37952113, "Oceanian": 0.46080005, "East Asian": 0.32628936, "Near Eastern": 0.459102, "Central/South Asian": 0.36526063, "Sub-Saharan African": 0.36808127, "African American/Afro-Caribbean": 0.4660738}
5885415	CYP2B6	Poor Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has two copies of a no function allele OR two copies of a decreased function allele OR one copy of a no function allele and one copy of a decreased function allele. Based on the genotype result this patient is predicted to be a poor metabolizer of CYP2B6 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2B6. To avoid an untoward drug response, dose adjustments or or alternative therapy may be necessary for medications metabolized by CYP2B6. Please consult a clinical pharmacist for more information about how CYP2B6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.09452413, "European": 0.07428478, "Oceanian": 0.4096, "East Asian": 0.0436291, "Near Eastern": 0.127449, "Central/South Asian": 0.059536003, "Sub-Saharan African": 0.23673655, "African American/Afro-Caribbean": 0.15714757}
5886633	CYP2C19	Likely Poor Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a decreased function allele and one copy of a no function allele. Based on the genotype result this patient MAY be a poor metabolizer of CYP2C19 substrates. This patient may be at a high risk for an adverse or poor response to medications that are metabolized by CYP2C19. To avoid an untoward drug response, dose adjustments or or alternative therapy may be necessary for medications metabolized by the CYP2C19. Please consult a clinical pharmacist for more information about how CYP2C19 metabolic status influences drug selection and dosing.	3	{"Latino": 0.0004440685, "American": 0.0, "European": 0.00020405183, "Oceanian": 0.0, "East Asian": 0.0004349198, "Near Eastern": 0.0, "Central/South Asian": 0.0, "Sub-Saharan African": 0.010332189, "African American/Afro-Caribbean": 0.007090685}
5886707	CYP2C19	Poor Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has two copies of a no function allele. Based on the genotype result this patient is predicted to be a poor metabolizer of CYP2C19 substrates. This patient may be at a high risk for an adverse or poor response to medications that are metabolized by CYP2C19. To avoid an untoward drug response, dose adjustments or or alternative therapy may be necessary for medications metabolized by the CYP2C19. Please consult a clinical pharmacist for more information about how CYP2C19 metabolic status influences drug selection and dosing.	3	{"Latino": 0.011408395, "American": 0.014819587, "European": 0.02387743, "Oceanian": 0.5713864, "East Asian": 0.12978691, "Near Eastern": 0.018584846, "Central/South Asian": 0.08156806, "Sub-Saharan African": 0.036714304, "African American/Afro-Caribbean": 0.040512204}
5887417	CYP2C9	Poor Metabolizer	0.5	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a decreased function allele and one copy of a no function allele. Based on the genotype result, this patient is predicted to be a CYP2C9 poor metabolizer. This patient may be at high risk for an adverse response to medications that are affected by CYP2C9. Please consult a clinical pharmacist for more specific information about how CYP2C9 intermediate metabolizer status influences drug dosing.	3	{"Latino": 0.007974847, "American": 0.0034911723, "European": 0.019907156, "Oceanian": 0.0009130932, "East Asian": 0.0030826868, "Near Eastern": 0.022547128, "Central/South Asian": 0.025517693, "Sub-Saharan African": 0.0049882242, "African American/Afro-Caribbean": 0.004712071}
5887692	CYP2C9	Poor Metabolizer	0.0	Abnormal/Priority/High Risk	This result signifies that the patient has two copies of no function alleles. Based on the genotype result, this patient is predicted to be a CYP2C9 poor metabolizer. This patient may be at high risk for an adverse response to medications that are affected by CYP2C9. Please consult a clinical pharmacist for more specific information about how CYP2C9 intermediate metabolizer status influences drug dosing.	3	{"Latino": 0.0017415384, "American": 0.00090327376, "European": 0.0057798154, "Oceanian": 0.00024261088, "East Asian": 0.0028714235, "Near Eastern": 0.007066085, "Central/South Asian": 0.012135133, "Sub-Saharan African": 0.0003982905, "African American/Afro-Caribbean": 0.00048520204}
5887785	CYP2C9	Indeterminate	n/a	none	This result signifies that the patient has an allele combination with uncertain and/or unknown function alleles. The expected phenotype for this patient cannot be determined currently based on the CYP2C9 diplotype result. Please consult a clinical pharmacist for more specific information about how CYP2C9 function influences drug dosing.	3	{"Latino": 0.0009997501, "American": 0.0, "European": 0.00059991, "Oceanian": 0.0, "East Asian": 0.0046076896, "Near Eastern": 0.0, "Central/South Asian": 0.0037963898, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": 0.0}
5890611	CYP2D6	Normal Metabolizer	1.25	Normal/Routine/ Low Risk	This result signifies that this patient has [1 copy of a normal function allele (*_)] or [2 copies of a decreased function allele with an activity value of 0.5 (*_x2)] and [1 copy of a decreased function allele with an activity value of 0.25 (*_)] OR *41x3 and [1 copy of a decreased function allele with an activity value of 0.5 (*_)] or [2 copies of a decreased function allele with an activity value of 0.25 (*_x2)]. Based on the genotype result this patient is predicted to be a normal metabolizer of CYP2D6 substrates. There is no reason to selectively adjust the dose of most medications that are metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.11888533, "American": 0.07351474, "European": 0.15507403, "Oceanian": 0.12359433, "East Asian": 0.3547828, "Near Eastern": 0.22410923, "Central/South Asian": 0.23109229, "Sub-Saharan African": 0.073030114, "African American/Afro-Caribbean": 0.07348749}
5890624	CYP2D6	Intermediate Metabolizer	1.0	Abnormal/Priority/High Risk	This result signifies that this patient has [1 copy of a normal function allele (*_)] [X copies of a decreased function allele (*_)] [X copies of a no function allele (*_)]. Based on the genotype result this patient is predicted to be an intermediate metabolizer of CYP2D6 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2D6. To avoid an untoward drug response, dose adjustments may be necessary for medications metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.2278144, "American": 0.21460281, "European": 0.28533316, "Oceanian": 0.077126324, "East Asian": 0.070599586, "Near Eastern": 0.14959782, "Central/South Asian": 0.17827679, "Sub-Saharan African": 0.20079781, "African American/Afro-Caribbean": 0.2080644}
5890635	CYP2D6	Intermediate Metabolizer	0.75	Abnormal/Priority/High Risk	This result signifies that this patient has has three copies of *41 (*41x3) and one copy of a no function allele (*_) OR [1 copy of a decreased function allele with an activity value of 0.25 (*_)] and [1 copy of a decreased function allele with an activity value of 0.5 (*_)] or [2 copies of a decreased function allele with an activity value of 0.25 (*_x2)] . Based on the genotype result this patient is predicted to be an intermediate metabolizer of CYP2D6 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2D6. To avoid an untoward drug response, dose adjustments may be necessary for medications metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.0074723335, "American": 0.00080644403, "European": 0.0025628314, "Oceanian": 0.00018655165, "East Asian": 0.020004882, "Near Eastern": 0.02042247, "Central/South Asian": 0.0010252715, "Sub-Saharan African": 0.05760366, "African American/Afro-Caribbean": 0.041067164}
5884397	CFTR	ivacaftor responsive in CF patients	n/a	\N	\N	1	\N
5885219	CFTR	ivacaftor non-responsive in CF patients	n/a	\N	\N	1	\N
5891803	CYP2D6	Intermediate Metabolizer	0.5	Abnormal/Priority/High Risk	This result signifies that this patient has [1 copy of a decreased function allele with an activity value of 0.5 (*_)] or [2 copies of a decreased function allele with an activity value of 0.25 (*_x2)] and one copy of a no function allele (*_) OR two copies for a decreased function allele with an activity value of 0.25 (*_/*_). Based on the genotype result this patient is predicted to be an intermediate metabolizer of CYP2D6 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2D6. To avoid an untoward drug response, dose adjustments may be necessary for medications metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.022830304, "American": 0.0047207433, "European": 0.023932345, "Oceanian": 0.008138877, "East Asian": 0.21193053, "Near Eastern": 0.06410619, "Central/South Asian": 0.040293686, "Sub-Saharan African": 0.0954133, "African American/Afro-Caribbean": 0.08539959}
5892357	CYP2D6	Intermediate Metabolizer	0.25	Abnormal/Priority/High Risk	This result signifies that this patient has one copy of a decreased function allele with an activity value of 0.25 (*_) and one copy of a no function allele (*_). Based on the genotype result this patient is predicted to be an intermediate metabolizer of CYP2D6 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2D6. To avoid an untoward drug response, dose adjustments may be necessary for medications metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.03277562, "American": 0.0138169695, "European": 0.07070104, "Oceanian": 0.010012345, "East Asian": 0.08220821, "Near Eastern": 0.06670452, "Central/South Asian": 0.060946763, "Sub-Saharan African": 0.027220901, "African American/Afro-Caribbean": 0.024385082}
5892773	CYP2D6	Poor Metabolizer	0.0	Abnormal/Priority/High Risk	This result signifies that the patient has two copies of a no function allele (*_/*_). Based on the genotype result this patient is predicted to be a poor metabolizer of CYP2D6 substrates. This patient may be at a high risk for an adverse or poor response to medications that are metabolized by CYP2D6. To avoid an untoward drug response, dose adjustments or alternative therapeutic agents may be necessary for medications metabolized by the CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.0311798, "American": 0.020160662, "European": 0.065024786, "Oceanian": 0.0031239481, "East Asian": 0.008123729, "Near Eastern": 0.021957064, "Central/South Asian": 0.023507897, "Sub-Saharan African": 0.020398295, "African American/Afro-Caribbean": 0.023474354}
5889996	CYP2D6	Ultrarapid Metabolizer	≥3.75	Abnormal/Priority/High Risk	This result signifies that this patient has [X copies of a normal function allele (*_xN)] [X copies of a decreased function allele (*_)] [X copies of a no function allele (*_)]. Based on the genotype result this patient is predicted to be an ultrarapid metabolizer of CYP2D6 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2D6. To avoid an untoward drug response, dose adjustments may be necessary for medications metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.0, "American": 0.0, "European": 0.0, "Oceanian": 0.0, "East Asian": 0.0, "Near Eastern": 0.0, "Central/South Asian": 0.0, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": 0.0}
5890028	CYP2D6	Ultrarapid Metabolizer	≥3.5	Abnormal/Priority/High Risk	This result signifies that this patient has [X copies of a normal function allele (*_xN)] [X copies of a decreased function allele (*_)] [X copies of a no function allele (*_)]. Based on the genotype result this patient is predicted to be an ultrarapid metabolizer of CYP2D6 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2D6. To avoid an untoward drug response, dose adjustments may be necessary for medications metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.00008051411, "American": 0.00001657463, "European": 0.000031193038, "Oceanian": 0.0, "East Asian": 0.00004386605, "Near Eastern": 0.0, "Central/South Asian": 0.0, "Sub-Saharan African": 0.0030223487, "African American/Afro-Caribbean": 0.0}
5890052	CYP2D6	Ultrarapid Metabolizer	≥3.25	Abnormal/Priority/High Risk	This result signifies that this patient has [X copies of a normal function allele (*_xN)] [X copies of a decreased function allele (*_)] [X copies of a no function allele (*_)]. Based on the genotype result this patient is predicted to be an ultrarapid metabolizer of CYP2D6 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2D6. To avoid an untoward drug response, dose adjustments may be necessary for medications metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.00018561553, "American": 0.00009731066, "European": 0.00046782166, "Oceanian": 0.0, "East Asian": 0.0009120896, "Near Eastern": 0.0, "Central/South Asian": 0.0, "Sub-Saharan African": 0.000952962, "African American/Afro-Caribbean": 0.0}
5890072	CYP2D6	Ultrarapid Metabolizer	≥3.0	Abnormal/Priority/High Risk	This result signifies that this patient has [X copies of a normal function allele (*_xN)] [X copies of a decreased function allele (*_)] [X copies of a no function allele (*_)]. Based on the genotype result this patient is predicted to be an ultrarapid metabolizer of CYP2D6 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2D6. To avoid an untoward drug response, dose adjustments may be necessary for medications metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.00035315607, "American": 0.0002839765, "European": 0.0008605249, "Oceanian": 0.0, "East Asian": 0.00018026348, "Near Eastern": 0.0, "Central/South Asian": 0.0, "Sub-Saharan African": 0.001428226, "African American/Afro-Caribbean": 0.0}
5889979	CYP2D6	Ultrarapid Metabolizer	≥6.0	Abnormal/Priority/High Risk	This result signifies that this patient has [X copies of a normal function allele (*_xN)] [X copies of a decreased function allele (*_)] [X copies of a no function allele (*_)]. Based on the genotype result this patient is predicted to be an ultrarapid metabolizer of CYP2D6 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2D6. To avoid an untoward drug response, dose adjustments may be necessary for medications metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.0000010000001, "American": 0.0000010000001, "European": 0.0000028470035, "Oceanian": 0.0, "East Asian": 0.0000010000001, "Near Eastern": 0.0, "Central/South Asian": 0.0, "Sub-Saharan African": 0.000025000001, "African American/Afro-Caribbean": 0.0}
5890190	CYP2D6	Ultrarapid Metabolizer	3.0	Abnormal/Priority/High Risk	This result signifies that this patient has [X copies of a normal function allele (*_xN)] [X copies of a decreased function allele (*_)] [X copies of a no function allele (*_)]. Based on the genotype result this patient is predicted to be an ultrarapid metabolizer of CYP2D6 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2D6. To avoid an untoward drug response, dose adjustments may be necessary for medications metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.035694193, "American": 0.048732717, "European": 0.019382542, "Oceanian": 0.16405001, "East Asian": 0.006179998, "Near Eastern": 0.06435209, "Central/South Asian": 0.014773737, "Sub-Saharan African": 0.019435417, "African American/Afro-Caribbean": 0.025694855}
5890183	CYP2D6	Ultrarapid Metabolizer	2.75	Abnormal/Priority/High Risk	This result signifies that this patient has [X copies of a normal function allele (*_xN)] [X copies of a decreased function allele (*_)] [X copies of a no function allele (*_)]. Based on the genotype result this patient is predicted to be an ultrarapid metabolizer of CYP2D6 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2D6. To avoid an untoward drug response, dose adjustments may be necessary for medications metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.0, "American": 0.0, "European": 0.0, "Oceanian": 0.0, "East Asian": 0.0, "Near Eastern": 0.0, "Central/South Asian": 0.0, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": 0.0}
5890257	CYP2D6	Ultrarapid Metabolizer	2.5	Abnormal/Priority/High Risk	This result signifies that this patient has [X copies of a normal function allele (*_xN)] [X copies of a decreased function allele (*_)]. Based on the genotype result this patient is predicted to be an ultrarapid metabolizer of CYP2D6 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2D6. To avoid an untoward drug response, dose adjustments may be necessary for medications metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.0022434974, "American": 0.0005345896, "European": 0.0003203256, "Oceanian": 0.00024761492, "East Asian": 0.00034846712, "Near Eastern": 0.005864233, "Central/South Asian": 0.00006554563, "Sub-Saharan African": 0.015329994, "African American/Afro-Caribbean": 0.01435911}
5885222	CYP2B6	Ultrarapid Metabolizer	n/a	Normal/Routine/Low Risk	This result signifies that the patient has two copies of increased function alleles. Based on the genotype result this patient is predicted to be an ultrarapid metabolizer of CYP2B6 substrates. There is no reason to selectively adjust the dose of most medications that are metabolized by CYP2B6. Please consult a clinical pharmacist for more information about how CYP2B6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.011284955, "European": 0.0016704409, "Oceanian": 0.0, "East Asian": 0.007088209, "Near Eastern": 0.010816, "Central/South Asian": 0.009801, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": 0.000106068765}
5885225	CYP2B6	Rapid Metabolizer	n/a	Normal/Routine/Low Risk	This result signifies that the patient has one copy of a normal function allele and one copy of an increased function allele. Based on the genotype result this patient is predicted to be a rapid metabolizer of CYP2B6 substrates. There is no reason to selectively adjust the dose of most medications that are metabolized by CYP2B6. Please consult a clinical pharmacist for more information about how CYP2B6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.1231214, "European": 0.05357082, "Oceanian": 0.0, "East Asian": 0.11734093, "Near Eastern": 0.112112, "Central/South Asian": 0.12859802, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": 0.011896482}
5885233	CYP2B6	Normal Metabolizer	n/a	Normal/Routine/Low Risk	This result signifies that the patient has two copies of normal function alleles. Based on the genotype result this patient is predicted to be an normal metabolizer of CYP2B6 substrates. There is no reason to selectively adjust the dose of most medications that are metabolized by CYP2B6. Please consult a clinical pharmacist for more information about how CYP2B6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.33582056, "European": 0.42950228, "Oceanian": 0.12960002, "East Asian": 0.48562673, "Near Eastern": 0.29052103, "Central/South Asian": 0.42183065, "Sub-Saharan African": 0.14307445, "African American/Afro-Caribbean": 0.333572}
5885672	CYP2B6	Indeterminate	n/a	none	This result signifies that the patient has an allele combination with uncertain and/or unknown function alleles. The expected phenotype for this patient cannot be determined currently based on the CYP2B6 diplotype result. Please consult a clinical pharmacist for more specific information about how CYP2B6 function influences drug dosing.	3	{"Latino": 0.013596146, "European": 0.06145065, "Oceanian": 0.0, "East Asian": 0.020025712, "Near Eastern": 0.0, "Central/South Asian": 0.014973663, "Sub-Saharan African": 0.25210795, "African American/Afro-Caribbean": 0.031204166}
5890314	CYP2D6	Normal Metabolizer	2.25	Normal/Routine/ Low Risk	This result signifies that this patient has two copies of a normal function allele (*_x2) and one copy of decreased function allele with an activity value of 0.25 (*_). Based on the genotype result this patient is predicted to be a normal metabolizer of CYP2D6 substrates. There is no reason to selectively adjust the dose of most medications that are metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.005172111, "American": 0.0031386076, "European": 0.004804125, "Oceanian": 0.021296859, "East Asian": 0.0072455397, "Near Eastern": 0.029094387, "Central/South Asian": 0.005050826, "Sub-Saharan African": 0.0048336256, "African American/Afro-Caribbean": 0.004428509}
5890361	CYP2D6	Normal Metabolizer	2.0	Normal/Routine/ Low Risk	This result signifies that this patient has [X copies of a normal function allele (*_xN)] [X copies of a decreased function allele (*_)] [X copies of a no function allele (*_)]. Based on the genotype result this patient is predicted to be a normal metabolizer of CYP2D6 substrates. There is no reason to selectively adjust the dose of most medications that are metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.42007107, "American": 0.57988566, "European": 0.32166475, "Oceanian": 0.48931405, "East Asian": 0.1527359, "Near Eastern": 0.2670007, "Central/South Asian": 0.34187043, "Sub-Saharan African": 0.15406683, "African American/Afro-Caribbean": 0.22171879}
5893856	CYP2D6	Indeterminate	n/a	none	This result signifies that the patient has an allele combination with uncertain and/or unknown function alleles. The expected phenotype for this patient cannot be determined currently based on the CYP2D6 diplotype result. Please consult a clinical pharmacist for more specific information about how CYP2D6 function influences drug dosing.	3	{"Latino": 0.041558996, "American": 0.02454997, "European": 0.03725156, "Oceanian": 0.087338224, "East Asian": 0.066782884, "Near Eastern": 0.03744279, "Central/South Asian": 0.09993659, "Sub-Saharan African": 0.09009597, "African American/Afro-Caribbean": 0.038868744}
5890166	CYP2D6	Ultrarapid Metabolizer	4.0	Abnormal/Priority/High Risk	This result signifies that this patient has [X copies of a normal function allele (*_xN)] [X copies of a decreased function allele (*_)] [X copies of a no function allele (*_)]. Based on the genotype result this patient is predicted to be an ultrarapid metabolizer of CYP2D6 substrates. This patient may be at risk for an adverse or poor response to medications that are metabolized by CYP2D6. To avoid an untoward drug response, dose adjustments may be necessary for medications metabolized by CYP2D6. Please consult a clinical pharmacist for more information about how CYP2D6 metabolic status influences drug selection and dosing.	3	{"Latino": 0.0007764387, "American": 0.0010402872, "European": 0.0003002313, "Oceanian": 0.014133941, "East Asian": 0.000063105406, "Near Eastern": 0.0041771694, "Central/South Asian": 0.00016144973, "Sub-Saharan African": 0.0006431835, "African American/Afro-Caribbean": 0.0007742127}
5905097	CYP3A5	Normal Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has two copies of a normal function allele. Patients with this genotype are expected to require higher starting tacrolimus dosing (1.5 times to 2 times the standard dose-maximum starting dose not to exceed 0.3mg/kg/day). Further dose adjustments or selection of alternative therapy may be necessary due to other clinical factors (e.g., medication interactions, or hepatic function). Please consult a clinical pharmacist for more specific dosing information.	3	{"Latino": 0.029857205, "European": 0.005491413, "East Asian": 0.064288594, "Near Eastern": 0.014869832, "Central/South Asian": 0.106746115, "Sub-Saharan African": 0.22983262, "African American/Afro-Caribbean": 0.20507748}
5905100	CYP3A5	Intermediate Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a normal function allele and one copy of a no function allele. Patients with this genotype are expected to require higher starting tacrolimus dosing (1.5 times to 2 times the standard dose-maximum starting dose not to exceed 0.3mg/kg/day). Further dose adjustments or selection of alternative therapy may be necessary due to other clinical factors (e.g., medication interactions, or hepatic function). Please consult a clinical pharmacist for more specific dosing information.	3	{"Latino": 0.28587034, "European": 0.13722531, "East Asian": 0.37852672, "Near Eastern": 0.21414419, "Central/South Asian": 0.43994826, "Sub-Saharan African": 0.499152, "African American/Afro-Caribbean": 0.4955547}
5905105	CYP3A5	Poor Metabolizer	n/a	Normal/Routine/Low Risk	This result signifies that the patient has two copies of a no function allele. Patients with this genotype are expected to require standard tacrolimus dosing. Please consult a clinical pharmacist for more specific dosing information.	3	{"Latino": 0.68427247, "European": 0.85728335, "East Asian": 0.5571847, "Near Eastern": 0.770986, "Central/South Asian": 0.45330563, "Sub-Saharan African": 0.2710154, "African American/Afro-Caribbean": 0.2993679}
5905113	CYP3A5	Possible Intermediate Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a normal function allele and one copy of an uncertain or unknown function allele. Patients with this genotype are expected to require higher starting tacrolimus dosing (1.5 times to 2 times the standard dose-maximum starting dose not to exceed 0.3mg/kg/day). Further dose adjustments or selection of alternative therapy may be necessary due to other clinical factors (e.g., medication interactions, or hepatic function). Please consult a clinical pharmacist for more specific dosing information.	3	{"Latino": 0.0, "European": 0.0, "East Asian": 0.0, "Near Eastern": 0.0, "Central/South Asian": 0.0, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": 0.0}
5905117	CYP3A5	Indeterminate	n/a	none	This result signifies that the patient has an allele combination with uncertain and/or unknown function alleles. The expected phenotype for this patient cannot be determined currently based on the CYP3A5 diplotype result. Please consult a clinical pharmacist for more specific information about how CYP3A5 function influences drug dosing.	3	{"Latino": 0.0, "European": 0.0, "East Asian": 0.0, "Near Eastern": 0.0, "Central/South Asian": 0.0, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": 0.0}
5906727	DPYD	Intermediate Metabolizer	1.5	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a normal function allele and one copy of a decreased function allele of the DPYD gene. Based on the genotype result this patient is predicted to be a DPYD Intermediate Metabolizer with a DPYD activity score of 1.5. This patient may be at risk for adverse drug reactions to medications that are metabolized by DPD (i.e. 5-fluorouracil, capecitabine, and tegafur) and a dose adjustment may be indicated. Please consult a clinical pharmacist for more information about how DPD metabolic status influences drug selection and dosing.	2	\N
5907121	DPYD	Intermediate Metabolizer	1.0	Abnormal/Priority/High Risk	This result signifies that the patient has either one copy of a normal function allele and one copy of a no function allele of the DPYD gene OR two copies of decreased function alleles of the DPYD gene. Based on the genotype result this patient is predicted to be a DPYD Intermediate Metabolizer with a DPYD activity score of 1. This patient may be at risk for adverse drug reactions to medications that are metabolized by DPD (i.e. 5-fluorouracil, capecitabine, and tegafur) and a dose adjustment may be indicated. Please consult a clinical pharmacist for more information about how DPD metabolic status influences drug selection and dosing.	2	\N
5908328	DPYD	Poor Metabolizer	0.5	Abnormal/Priority/High Risk	This result signifies that the patient has one copy of a decreased function allele and one copy of a no function allele of the DPYD gene. Based on the genotype result this patient is predicted to be a DPYD Poor Metabolizer with a DPYD activity score of 0.5. This patient may be at risk for adverse drug reactions to medications that are metabolized by DPD (i.e. 5-fluorouracil, capecitabine, and tegafur) and a dose adjustment or alternative therapeutic agents may be indicated. Please consult a clinical pharmacist for more information about how DPD metabolic status influences drug selection and dosing.	2	\N
5908477	DPYD	Poor Metabolizer	0.0	Abnormal/Priority/High Risk	This result signifies that the patient has two copies of no function alleles of the DPYD gene. Based on the genotype result this patient is predicted to be a DPYD Poor Metabolizer with a DPYD activity score of 0. This patient may be at risk for adverse drug reactions to medications that are metabolized by DPD (i.e. 5-fluorouracil, capecitabine, and tegafur) and alternative therapeutic agents may be indicated. Please consult a clinical pharmacist for more information about how DPD metabolic status influences drug selection and dosing.	2	\N
5908710	G6PD	Normal	n/a	Normal Risk	Based on the genotype result, this patient is predicted to have normal G6PD enzyme activity. This means there is no reason to selectively avoid G6PD associated medications based on the G6PD status alone. Please consult a clinical pharmacist for more information.	2	\N
5908717	G6PD	Deficient	n/a	Abnormal/Priority/High Risk	Based on the genotype result, this patient is predicted to be G6PD deficient and is at risk for developing hemolytic anemia when exposed to certain medications (such as dapsone, methylene blue, pegloticase, primaquine (at certain doses), rasburicase, tafenoquine, toluidine blue) or foods (such as fava beans). Please consult a clinical pharmacist for more information.	2	\N
5908810	G6PD	Deficient with CNSHA	n/a	Abnormal/Priority/High Risk	Based on the genotype result, this patient is predicted to be G6PD deficient with CNSHA and is at risk for developing or worsening hemolytic anemia when exposed to certain medications (such as dapsone, methylene blue, pegloticase, primaquine (at certain doses), rasburicase, tafenoquine, toluidine blue) or foods (such as fava beans). Please consult a clinical pharmacist for more information.	2	\N
5908914	G6PD	Variable	n/a	Abnormal/Priority/High Risk	This patient carries one copy of a deficient G6PD allele and one copy of a normal G6PD allele. Due to X inactivation, patients who are heterozygous with one deficient allele and one normal allele may exhibit G6PD activity ranging from normal to deficient. A G6PD enzyme activity test is recommended to assess for G6PD deficiency. Please consult a clinical pharmacist for more information.	2	\N
5925380	G6PD	Indeterminate	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has an allele combination with uncertain and/or unknown function alleles. The expected phenotype for this patient cannot be determined currently based on genotype alone. A G6PD enzyme activity test is recommended to assess for G6PD deficiency. Please consult a clinical pharmacist for more specific information about how G6PD function influences drug dosing.	2	\N
5926500	MT-RNR1	increased risk of aminoglycoside-induced hearing loss	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has a copy of the MT-RNR1 [variant]. Based on this genotype result, the patient is predicted to be at increased risk of aminoglycoside-induced hearing loss. This means that the patient is likely to develop irreversible hearing loss if aminoglycosides (e.g. amikacin, gentamicin, tobramycin) are prescribed. Please consult a clinical pharmacist or Infectious Diseases Service for help selecting alternative therapies.	2	\N
5926505	MT-RNR1	normal risk of aminoglycoside-induced hearing loss	n/a	Normal/Routine/Low Risk	This result signifies that MT-RNR1 variants associated with aminoglycoside-induced hearing loss were not detected in this patient. Based on this genotype result, no change in aminoglycoside therapy is warranted. It should be noted that this result does not absolutely rule out the possibility of the patient developing ototoxicity with aminoglycoside use.	2	\N
5926508	MT-RNR1	uncertain risk of aminoglycoside-induced hearing loss	n/a	Normal/Routine/Low Risk	This result signifies that the patient has a copy of MT-RNR1 [variant]. At this time, the association of this allele with aminoglycoside-induced hearing loss is unknown/uncertain. Based on this genotype result, no change in aminoglycoside therapy is warranted. It should be noted that this result does not absolutely rule out the possibility of the patient developing ototoxicity with aminoglycoside use.	2	\N
5926538	NUDT15	Poor Metabolizer	n/a	Abnormal/Priority/High Risk	This result signifies that the patient has two copies of a no function allele. Based on the genotype result this patient is predicted to be a NUDT15 poor metabolizer. This patient may be at a high risk for an adverse reactions to medications that are metabolized by NUDT15 (eg. thiopurines). To avoid an untoward drug response, dose adjustments or or alternative therapy may be necessary for medications metabolized by NUDT15. Please consult a clinical pharmacist for more information about how NUDT15 metabolic status influences drug selection and dosing.	3	{"Latino": 0.0019588957, "European": 0.000014661539, "East Asian": 0.00912025, "Central/South Asian": 0.0045555667}
5926530	NUDT15	Normal Metabolizer	n/a	Normal/Routine/Low Risk	This result signifies that the patient has two copies of a normal function allele. Based on the genotype result this patient is predicted to be a NUDT15 normal metabolizer. There is no reason to selectively adjust the dose of most medications that are metabolized by NUDT15. Please consult a clinical pharmacist for more information about how NUDT15 metabolic status influences drug selection and dosing.	3	{"Latino": 0.8768086, "European": 0.98630786, "East Asian": 0.77218705, "Central/South Asian": 0.86494493}
\.


--
-- Data for Name: gene_result_diplotype; Type: TABLE DATA; Schema: cpic; Owner: -
--

COPY cpic.gene_result_diplotype (id, functionphenotypeid, diplotype, diplotypekey, frequency) FROM stdin;
5933130	5927084	c.5024T>C/c.8360C>G	{"RYR1": {"c.5024T>C": 1, "c.8360C>G": 1}}	\N
5933131	5927084	c.6670C>T/c.10556C>T	{"RYR1": {"c.6670C>T": 1, "c.10556C>T": 1}}	\N
5933132	5927084	c.178G>T/c.10616G>A	{"RYR1": {"c.178G>T": 1, "c.10616G>A": 1}}	\N
5933133	5927084	c.2996G>A/c.13513G>C	{"RYR1": {"c.2996G>A": 1, "c.13513G>C": 1}}	\N
5933134	5927084	c.8360C>G/c.9676G>C	{"RYR1": {"c.8360C>G": 1, "c.9676G>C": 1}}	\N
5933135	5927084	c.6635T>A/Reference	{"RYR1": {"Reference": 1, "c.6635T>A": 1}}	\N
5933136	5927084	c.488G>A/c.10097G>A	{"RYR1": {"c.488G>A": 1, "c.10097G>A": 1}}	\N
5933137	5927084	c.3166G>A/c.10747G>C	{"RYR1": {"c.3166G>A": 1, "c.10747G>C": 1}}	\N
5933138	5927084	c.212C>A/c.10747G>C	{"RYR1": {"c.212C>A": 1, "c.10747G>C": 1}}	\N
5933139	5927084	c.6670C>T/c.7292A>T	{"RYR1": {"c.6670C>T": 1, "c.7292A>T": 1}}	\N
5933140	5927084	c.7771C>T/c.10100A>G	{"RYR1": {"c.7771C>T": 1, "c.10100A>G": 1}}	\N
5933141	5927084	c.1598G>A/c.6178G>T	{"RYR1": {"c.1598G>A": 1, "c.6178G>T": 1}}	\N
5933142	5927084	c.7032G>C/Reference	{"RYR1": {"Reference": 1, "c.7032G>C": 1}}	\N
5933143	5927084	c.10616G>A/c.11748T>G	{"RYR1": {"c.10616G>A": 1, "c.11748T>G": 1}}	\N
5933144	5927084	c.4711A>G/c.14197T>G	{"RYR1": {"c.4711A>G": 1, "c.14197T>G": 1}}	\N
5933145	5927084	c.1201C>G/c.7025A>G	{"RYR1": {"c.1201C>G": 1, "c.7025A>G": 1}}	\N
5933146	5927084	c.10100A>G/c.10229C>A	{"RYR1": {"c.10100A>G": 1, "c.10229C>A": 1}}	\N
5933147	5927084	c.5341T>C/c.10100A>G	{"RYR1": {"c.5341T>C": 1, "c.10100A>G": 1}}	\N
5933148	5927084	c.8654C>G/c.12310G>C	{"RYR1": {"c.8654C>G": 1, "c.12310G>C": 1}}	\N
5933149	5927084	c.190T>C/c.14168G>A	{"RYR1": {"c.190T>C": 1, "c.14168G>A": 1}}	\N
5933150	5927084	c.1422G>T/c.10616G>A	{"RYR1": {"c.1422G>T": 1, "c.10616G>A": 1}}	\N
5933151	5927084	c.1144C>A/c.14510delA	{"RYR1": {"c.1144C>A": 1, "c.14510delA": 1}}	\N
5933152	5927084	c.1209C>G/c.12884C>T	{"RYR1": {"c.1209C>G": 1, "c.12884C>T": 1}}	\N
5933153	5927084	c.11132C>T/c.12884C>T	{"RYR1": {"c.11132C>T": 1, "c.12884C>T": 1}}	\N
5933154	5927084	c.2654G>A/c.6178G>T	{"RYR1": {"c.2654G>A": 1, "c.6178G>T": 1}}	\N
5933155	5927084	c.6961A>G/c.10042C>T	{"RYR1": {"c.6961A>G": 1, "c.10042C>T": 1}}	\N
5933156	5927084	c.12689T>G/c.14168G>A	{"RYR1": {"c.12689T>G": 1, "c.14168G>A": 1}}	\N
5933157	5927084	c.11798A>G/c.12242C>T	{"RYR1": {"c.11798A>G": 1, "c.12242C>T": 1}}	\N
5933158	5927084	c.9797T>C/c.14510delA	{"RYR1": {"c.9797T>C": 1, "c.14510delA": 1}}	\N
5933159	5927084	c.5036G>A/c.11086G>C	{"RYR1": {"c.5036G>A": 1, "c.11086G>C": 1}}	\N
5933160	5927084	c.6670C>T/c.7879G>A	{"RYR1": {"c.6670C>T": 1, "c.7879G>A": 1}}	\N
5933161	5927084	c.5036G>A/c.11958C>G	{"RYR1": {"c.5036G>A": 1, "c.11958C>G": 1}}	\N
5933162	5927084	c.2654G>A/c.5360C>T	{"RYR1": {"c.2654G>A": 1, "c.5360C>T": 1}}	\N
5933163	5927084	c.11266C>G/c.14270G>A	{"RYR1": {"c.11266C>G": 1, "c.14270G>A": 1}}	\N
5933164	5927084	c.7355G>A/c.12310G>C	{"RYR1": {"c.7355G>A": 1, "c.12310G>C": 1}}	\N
5933165	5927084	c.10097G>A/c.12242C>T	{"RYR1": {"c.10097G>A": 1, "c.12242C>T": 1}}	\N
5933166	5927084	c.10747G>C/c.14817C>A	{"RYR1": {"c.10747G>C": 1, "c.14817C>A": 1}}	\N
5933167	5927084	c.4747C>T/c.6178G>T	{"RYR1": {"c.4747C>T": 1, "c.6178G>T": 1}}	\N
5933168	5927084	c.2537C>T/c.14510delA	{"RYR1": {"c.2537C>T": 1, "c.14510delA": 1}}	\N
5933169	5927084	c.6037A>C/c.10616G>A	{"RYR1": {"c.6037A>C": 1, "c.10616G>A": 1}}	\N
5933170	5927084	c.5360C>T/c.14387A>G	{"RYR1": {"c.5360C>T": 1, "c.14387A>G": 1}}	\N
5933171	5927084	c.10750G>C/c.12881C>T	{"RYR1": {"c.10750G>C": 1, "c.12881C>T": 1}}	\N
5933172	5927084	c.496G>A/c.8327C>T	{"RYR1": {"c.496G>A": 1, "c.8327C>T": 1}}	\N
5933173	5927084	c.9356G>A/c.12310G>C	{"RYR1": {"c.9356G>A": 1, "c.12310G>C": 1}}	\N
5933174	5927084	c.533A>C/c.10747G>C	{"RYR1": {"c.533A>C": 1, "c.10747G>C": 1}}	\N
5933175	5927084	c.6178G>T/c.7307G>A	{"RYR1": {"c.6178G>T": 1, "c.7307G>A": 1}}	\N
5933176	5927084	c.2447C>T/c.9848G>A	{"RYR1": {"c.2447C>T": 1, "c.9848G>A": 1}}	\N
5933177	5927084	c.8005G>A/c.8360C>G	{"RYR1": {"c.8005G>A": 1, "c.8360C>G": 1}}	\N
5933178	5927084	c.4178A>G/c.7075C>T	{"RYR1": {"c.4178A>G": 1, "c.7075C>T": 1}}	\N
5933179	5927084	c.1201C>A/c.7025A>G	{"RYR1": {"c.1201C>A": 1, "c.7025A>G": 1}}	\N
5933180	5927084	c.12406C>A/c.14813T>C	{"RYR1": {"c.12406C>A": 1, "c.14813T>C": 1}}	\N
5933181	5927084	c.5036G>A/c.14270G>A	{"RYR1": {"c.5036G>A": 1, "c.14270G>A": 1}}	\N
5933182	5927084	c.652G>A/c.8360C>G	{"RYR1": {"c.652G>A": 1, "c.8360C>G": 1}}	\N
5933183	5927084	c.6478G>A/c.6961A>G	{"RYR1": {"c.6478G>A": 1, "c.6961A>G": 1}}	\N
5933184	5927084	c.6478G>A/c.12406C>A	{"RYR1": {"c.6478G>A": 1, "c.12406C>A": 1}}	\N
5933185	5927084	c.14168G>A/c.14509C>G	{"RYR1": {"c.14168G>A": 1, "c.14509C>G": 1}}	\N
5933186	5927084	c.1834G>C/c.7025A>G	{"RYR1": {"c.1834G>C": 1, "c.7025A>G": 1}}	\N
5933187	5927084	c.7355G>C/c.12310G>C	{"RYR1": {"c.7355G>C": 1, "c.12310G>C": 1}}	\N
5933188	5927084	c.8527T>C/c.11798A>G	{"RYR1": {"c.8527T>C": 1, "c.11798A>G": 1}}	\N
5933189	5927084	c.5036G>A/c.11723A>T	{"RYR1": {"c.5036G>A": 1, "c.11723A>T": 1}}	\N
5933190	5927084	c.418G>A/c.7307G>A	{"RYR1": {"c.418G>A": 1, "c.7307G>A": 1}}	\N
5933191	5927084	c.12406C>A/c.14693T>C	{"RYR1": {"c.12406C>A": 1, "c.14693T>C": 1}}	\N
5933192	5927084	c.11266C>G/c.14422_14423delinsAA	{"RYR1": {"c.11266C>G": 1, "c.14422_14423delinsAA": 1}}	\N
5933193	5927084	c.7528T>C/c.10097G>A	{"RYR1": {"c.7528T>C": 1, "c.10097G>A": 1}}	\N
5933194	5927084	c.1553T>C/c.12884C>T	{"RYR1": {"c.1553T>C": 1, "c.12884C>T": 1}}	\N
5933195	5927084	c.3224G>A/c.14639T>C	{"RYR1": {"c.3224G>A": 1, "c.14639T>C": 1}}	\N
5933196	5927084	c.4711A>G/c.7307G>A	{"RYR1": {"c.4711A>G": 1, "c.7307G>A": 1}}	\N
5933197	5927084	c.680A>T/c.8327C>T	{"RYR1": {"c.680A>T": 1, "c.8327C>T": 1}}	\N
5933198	5927084	c.1209C>G/c.4711A>G	{"RYR1": {"c.1209C>G": 1, "c.4711A>G": 1}}	\N
5933199	5927084	c.152C>A/c.6670C>T	{"RYR1": {"c.152C>A": 1, "c.6670C>T": 1}}	\N
5933200	5927084	c.528G>T/c.12884C>T	{"RYR1": {"c.528G>T": 1, "c.12884C>T": 1}}	\N
5933201	5927084	c.467G>A/c.8327C>T	{"RYR1": {"c.467G>A": 1, "c.8327C>T": 1}}	\N
5933202	5927084	c.7085A>G/c.10097G>A	{"RYR1": {"c.7085A>G": 1, "c.10097G>A": 1}}	\N
5933203	5927084	c.5360C>T/c.7879G>A	{"RYR1": {"c.5360C>T": 1, "c.7879G>A": 1}}	\N
5933204	5927084	c.9676G>C/c.11798A>G	{"RYR1": {"c.9676G>C": 1, "c.11798A>G": 1}}	\N
5933205	5927084	c.493G>A/c.4711A>G	{"RYR1": {"c.493G>A": 1, "c.4711A>G": 1}}	\N
5933206	5927084	c.8005G>A/c.12310G>C	{"RYR1": {"c.8005G>A": 1, "c.12310G>C": 1}}	\N
5933207	5927084	c.5441T>A/c.6670C>T	{"RYR1": {"c.5441T>A": 1, "c.6670C>T": 1}}	\N
5933208	5927084	c.2447C>T/c.6544A>T	{"RYR1": {"c.2447C>T": 1, "c.6544A>T": 1}}	\N
5933209	5927084	c.152C>A/c.13513G>C	{"RYR1": {"c.152C>A": 1, "c.13513G>C": 1}}	\N
5933210	5927084	c.6670C>T/c.14387A>G	{"RYR1": {"c.6670C>T": 1, "c.14387A>G": 1}}	\N
5933211	5927084	c.6388G>A/c.10097G>A	{"RYR1": {"c.6388G>A": 1, "c.10097G>A": 1}}	\N
5933212	5927084	c.4711A>G/c.8198G>A	{"RYR1": {"c.4711A>G": 1, "c.8198G>A": 1}}	\N
5933213	5927084	c.10616G>A/c.13934G>A	{"RYR1": {"c.10616G>A": 1, "c.13934G>A": 1}}	\N
5933214	5927084	c.6961A>G/c.8638G>A	{"RYR1": {"c.6961A>G": 1, "c.8638G>A": 1}}	\N
5933215	5927084	c.946C>T/c.10747G>C	{"RYR1": {"c.946C>T": 1, "c.10747G>C": 1}}	\N
5933216	5927084	c.526G>A/c.14510delA	{"RYR1": {"c.526G>A": 1, "c.14510delA": 1}}	\N
5933217	5927084	c.3095G>A/c.3224G>A	{"RYR1": {"c.3095G>A": 1, "c.3224G>A": 1}}	\N
5933218	5927084	c.7816T>A/c.13505A>G	{"RYR1": {"c.7816T>A": 1, "c.13505A>G": 1}}	\N
5933219	5927084	c.1201C>G/c.5317C>T	{"RYR1": {"c.1201C>G": 1, "c.5317C>T": 1}}	\N
5933220	5927084	c.10229C>A/c.12310G>C	{"RYR1": {"c.10229C>A": 1, "c.12310G>C": 1}}	\N
5933221	5927084	c.3166G>A/c.13513G>C	{"RYR1": {"c.3166G>A": 1, "c.13513G>C": 1}}	\N
5933222	5927084	c.8360C>G/c.11947C>T	{"RYR1": {"c.8360C>G": 1, "c.11947C>T": 1}}	\N
5933223	5927084	c.8729C>T/c.12884C>T	{"RYR1": {"c.8729C>T": 1, "c.12884C>T": 1}}	\N
5933224	5927084	c.5024T>C/c.12310G>C	{"RYR1": {"c.5024T>C": 1, "c.12310G>C": 1}}	\N
5933225	5927084	c.1475G>A/c.14510delA	{"RYR1": {"c.1475G>A": 1, "c.14510delA": 1}}	\N
5933226	5927084	c.13513G>C/c.14558C>T	{"RYR1": {"c.13513G>C": 1, "c.14558C>T": 1}}	\N
5933227	5927084	c.497A>G/c.10747G>C	{"RYR1": {"c.497A>G": 1, "c.10747G>C": 1}}	\N
5933228	5927084	c.3224G>A/c.6304G>C	{"RYR1": {"c.3224G>A": 1, "c.6304G>C": 1}}	\N
5933229	5927084	c.7210G>A/Reference	{"RYR1": {"Reference": 1, "c.7210G>A": 1}}	\N
5933230	5927084	c.12242C>T/c.14168G>A	{"RYR1": {"c.12242C>T": 1, "c.14168G>A": 1}}	\N
5933231	5927084	c.1024G>A/c.6178G>T	{"RYR1": {"c.1024G>A": 1, "c.6178G>T": 1}}	\N
5933232	5927084	c.5036G>A/c.13702C>G	{"RYR1": {"c.5036G>A": 1, "c.13702C>G": 1}}	\N
5933233	5927084	c.1460T>C/c.4178A>G	{"RYR1": {"c.1460T>C": 1, "c.4178A>G": 1}}	\N
5933234	5927084	c.1553T>C/c.4711A>G	{"RYR1": {"c.1553T>C": 1, "c.4711A>G": 1}}	\N
5933235	5927084	c.10100A>G/c.14567C>G	{"RYR1": {"c.10100A>G": 1, "c.14567C>G": 1}}	\N
5933236	5927084	c.5024T>C/c.6178G>T	{"RYR1": {"c.5024T>C": 1, "c.6178G>T": 1}}	\N
5933237	5927084	c.7787C>T/c.8327C>T	{"RYR1": {"c.7787C>T": 1, "c.8327C>T": 1}}	\N
5933238	5927084	c.9676G>C/c.12310G>C	{"RYR1": {"c.9676G>C": 1, "c.12310G>C": 1}}	\N
5933239	5927084	c.6961A>G/c.7199A>G	{"RYR1": {"c.6961A>G": 1, "c.7199A>G": 1}}	\N
5933240	5927084	c.10097G>A/c.14197T>G	{"RYR1": {"c.10097G>A": 1, "c.14197T>G": 1}}	\N
5933241	5927084	c.652G>A/c.2447C>T	{"RYR1": {"c.652G>A": 1, "c.2447C>T": 1}}	\N
5933242	5927084	c.5036G>A/c.6757C>T	{"RYR1": {"c.5036G>A": 1, "c.6757C>T": 1}}	\N
5933243	5927084	c.8327C>T/c.14201G>A	{"RYR1": {"c.8327C>T": 1, "c.14201G>A": 1}}	\N
5933244	5927084	c.12884C>T/c.14680G>A	{"RYR1": {"c.12884C>T": 1, "c.14680G>A": 1}}	\N
5933245	5927084	c.7777C>G/c.12884C>T	{"RYR1": {"c.7777C>G": 1, "c.12884C>T": 1}}	\N
5933246	5927084	c.5036G>A/c.7075C>T	{"RYR1": {"c.5036G>A": 1, "c.7075C>T": 1}}	\N
5933247	5927084	c.2654G>A/c.3224G>A	{"RYR1": {"c.2654G>A": 1, "c.3224G>A": 1}}	\N
5933248	5927084	c.488G>A/c.4178A>G	{"RYR1": {"c.488G>A": 1, "c.4178A>G": 1}}	\N
5933249	5927084	c.5132A>G/c.14168G>A	{"RYR1": {"c.5132A>G": 1, "c.14168G>A": 1}}	\N
5933250	5927084	c.3224G>A/c.11813G>A	{"RYR1": {"c.3224G>A": 1, "c.11813G>A": 1}}	\N
5933251	5927084	c.7025A>G/c.14581C>T	{"RYR1": {"c.7025A>G": 1, "c.14581C>T": 1}}	\N
5933252	5927084	c.418G>A/c.9848G>A	{"RYR1": {"c.418G>A": 1, "c.9848G>A": 1}}	\N
5933253	5927084	c.418G>A/c.13505A>G	{"RYR1": {"c.418G>A": 1, "c.13505A>G": 1}}	\N
5933254	5927084	c.8360C>G/c.14387A>G	{"RYR1": {"c.8360C>G": 1, "c.14387A>G": 1}}	\N
5933255	5927084	c.6961A>G/c.7760A>G	{"RYR1": {"c.6961A>G": 1, "c.7760A>G": 1}}	\N
5933256	5927084	c.6961A>G/c.14126C>T	{"RYR1": {"c.6961A>G": 1, "c.14126C>T": 1}}	\N
5933257	5927084	c.7097C>G/c.12881C>T	{"RYR1": {"c.7097C>G": 1, "c.12881C>T": 1}}	\N
5933258	5927084	c.7778G>A/c.13513G>C	{"RYR1": {"c.7778G>A": 1, "c.13513G>C": 1}}	\N
5933259	5927084	c.7528T>C/c.10100A>G	{"RYR1": {"c.7528T>C": 1, "c.10100A>G": 1}}	\N
5933260	5927084	c.4775C>T/c.7025A>G	{"RYR1": {"c.4775C>T": 1, "c.7025A>G": 1}}	\N
5933261	5927084	c.6377G>A/c.12406C>A	{"RYR1": {"c.6377G>A": 1, "c.12406C>A": 1}}	\N
5933262	5927084	c.5036G>A/c.7317G>C	{"RYR1": {"c.5036G>A": 1, "c.7317G>C": 1}}	\N
5933263	5927084	c.3224G>A/c.13673G>A	{"RYR1": {"c.3224G>A": 1, "c.13673G>A": 1}}	\N
5933264	5927084	c.479A>G/c.2447C>T	{"RYR1": {"c.479A>G": 1, "c.2447C>T": 1}}	\N
5933265	5927084	c.2447C>T/c.12553G>A	{"RYR1": {"c.2447C>T": 1, "c.12553G>A": 1}}	\N
5933266	5927084	c.2797G>A/c.10237A>T	{"RYR1": {"c.2797G>A": 1, "c.10237A>T": 1}}	\N
5933267	5927084	c.10252A>G/c.10747G>C	{"RYR1": {"c.10252A>G": 1, "c.10747G>C": 1}}	\N
5933268	5927084	c.12398A>G/c.12406C>A	{"RYR1": {"c.12398A>G": 1, "c.12406C>A": 1}}	\N
5933269	5927084	c.652G>A/c.12310G>C	{"RYR1": {"c.652G>A": 1, "c.12310G>C": 1}}	\N
5933270	5927084	c.418G>A/c.6377G>A	{"RYR1": {"c.418G>A": 1, "c.6377G>A": 1}}	\N
5933271	5927084	c.488G>A/c.10100A>G	{"RYR1": {"c.488G>A": 1, "c.10100A>G": 1}}	\N
5933272	5927084	c.11798A>G/c.14449A>T	{"RYR1": {"c.11798A>G": 1, "c.14449A>T": 1}}	\N
5933273	5927084	c.1460T>C/c.6670C>T	{"RYR1": {"c.1460T>C": 1, "c.6670C>T": 1}}	\N
5933274	5927084	c.7099G>A/c.12881C>T	{"RYR1": {"c.7099G>A": 1, "c.12881C>T": 1}}	\N
5933275	5927084	c.5036G>A/c.10891G>T	{"RYR1": {"c.5036G>A": 1, "c.10891G>T": 1}}	\N
5933276	5927084	c.6178G>T/c.7097C>G	{"RYR1": {"c.6178G>T": 1, "c.7097C>G": 1}}	\N
5933277	5927084	c.8518C>T/c.13513G>C	{"RYR1": {"c.8518C>T": 1, "c.13513G>C": 1}}	\N
5933278	5927084	c.5317C>T/c.12553G>A	{"RYR1": {"c.5317C>T": 1, "c.12553G>A": 1}}	\N
5933279	5927084	c.6742C>T/c.14168G>A	{"RYR1": {"c.6742C>T": 1, "c.14168G>A": 1}}	\N
5933280	5927084	c.1597C>A/c.14510delA	{"RYR1": {"c.1597C>A": 1, "c.14510delA": 1}}	\N
5933281	5927084	c.4711A>G/c.7777C>G	{"RYR1": {"c.4711A>G": 1, "c.7777C>G": 1}}	\N
5933282	5927084	c.1453A>G/c.6178G>T	{"RYR1": {"c.1453A>G": 1, "c.6178G>T": 1}}	\N
5933283	5927084	c.4711A>G/c.14509C>G	{"RYR1": {"c.4711A>G": 1, "c.14509C>G": 1}}	\N
5933284	5927084	c.5036G>A/c.14680G>A	{"RYR1": {"c.5036G>A": 1, "c.14680G>A": 1}}	\N
5933285	5927084	c.7771C>T/c.10747G>C	{"RYR1": {"c.7771C>T": 1, "c.10747G>C": 1}}	\N
5933286	5927084	c.6302T>A/c.10747G>C	{"RYR1": {"c.6302T>A": 1, "c.10747G>C": 1}}	\N
5933287	5927084	c.7879G>A/c.14168G>A	{"RYR1": {"c.7879G>A": 1, "c.14168G>A": 1}}	\N
5933288	5927084	c.5360C>T/c.10891G>T	{"RYR1": {"c.5360C>T": 1, "c.10891G>T": 1}}	\N
5933289	5927084	c.6670C>T/c.14051T>C	{"RYR1": {"c.6670C>T": 1, "c.14051T>C": 1}}	\N
5933290	5927084	c.4711A>G/c.7089C>G	{"RYR1": {"c.4711A>G": 1, "c.7089C>G": 1}}	\N
5933291	5927084	c.10747G>C/c.13990T>C	{"RYR1": {"c.10747G>C": 1, "c.13990T>C": 1}}	\N
5933292	5927084	c.9868G>A/c.14168G>A	{"RYR1": {"c.9868G>A": 1, "c.14168G>A": 1}}	\N
5933293	5927084	c.4711A>G/c.7112A>G	{"RYR1": {"c.4711A>G": 1, "c.7112A>G": 1}}	\N
5933294	5927084	c.4747C>T/c.8360C>G	{"RYR1": {"c.4747C>T": 1, "c.8360C>G": 1}}	\N
5933295	5927084	c.5360C>T/c.14680G>A	{"RYR1": {"c.5360C>T": 1, "c.14680G>A": 1}}	\N
5933296	5927084	c.418G>A/c.2654G>A	{"RYR1": {"c.418G>A": 1, "c.2654G>A": 1}}	\N
5933297	5927084	c.12881C>T/c.13918A>G	{"RYR1": {"c.12881C>T": 1, "c.13918A>G": 1}}	\N
5933298	5927084	c.2797G>A/c.6548G>A	{"RYR1": {"c.2797G>A": 1, "c.6548G>A": 1}}	\N
5933299	5927084	c.12121C>T/c.13513G>C	{"RYR1": {"c.12121C>T": 1, "c.13513G>C": 1}}	\N
5933300	5927084	c.8327C>T/c.11086G>C	{"RYR1": {"c.8327C>T": 1, "c.11086G>C": 1}}	\N
5933301	5927084	c.488G>A/c.14168G>A	{"RYR1": {"c.488G>A": 1, "c.14168G>A": 1}}	\N
5933302	5927084	c.5036G>A/c.12848A>T	{"RYR1": {"c.5036G>A": 1, "c.12848A>T": 1}}	\N
5933303	5927084	c.947G>T/c.2797G>A	{"RYR1": {"c.947G>T": 1, "c.2797G>A": 1}}	\N
5933304	5927084	c.4747C>T/c.12310G>C	{"RYR1": {"c.4747C>T": 1, "c.12310G>C": 1}}	\N
5933305	5927084	c.3095G>A/c.11798A>G	{"RYR1": {"c.3095G>A": 1, "c.11798A>G": 1}}	\N
5933306	5927084	c.5036G>A/c.7787C>T	{"RYR1": {"c.5036G>A": 1, "c.7787C>T": 1}}	\N
5933307	5927084	c.1411C>T/c.10616G>A	{"RYR1": {"c.1411C>T": 1, "c.10616G>A": 1}}	\N
5933308	5927084	c.5341T>C/c.10747G>C	{"RYR1": {"c.5341T>C": 1, "c.10747G>C": 1}}	\N
5933309	5927084	c.14510delA/c.14581C>T	{"RYR1": {"c.14581C>T": 1, "c.14510delA": 1}}	\N
5933310	5927084	c.2797G>A/c.6640G>A	{"RYR1": {"c.2797G>A": 1, "c.6640G>A": 1}}	\N
5933311	5927084	c.13918A>G/Reference	{"RYR1": {"Reference": 1, "c.13918A>G": 1}}	\N
5933312	5927084	c.2797G>A/c.7355G>C	{"RYR1": {"c.2797G>A": 1, "c.7355G>C": 1}}	\N
5933313	5927084	c.6548G>A/c.12881C>T	{"RYR1": {"c.6548G>A": 1, "c.12881C>T": 1}}	\N
5933314	5927084	c.2797G>A/c.7355G>A	{"RYR1": {"c.2797G>A": 1, "c.7355G>A": 1}}	\N
5933315	5927084	c.6599C>T/c.13513G>C	{"RYR1": {"c.6599C>T": 1, "c.13513G>C": 1}}	\N
5933316	5927084	c.6178G>T/c.7073T>A	{"RYR1": {"c.6178G>T": 1, "c.7073T>A": 1}}	\N
5933317	5927084	c.11748T>G/c.12884C>T	{"RYR1": {"c.11748T>G": 1, "c.12884C>T": 1}}	\N
5933318	5927084	c.5186T>G/c.8360C>G	{"RYR1": {"c.5186T>G": 1, "c.8360C>G": 1}}	\N
5933319	5927084	c.5360C>T/c.14002C>T	{"RYR1": {"c.5360C>T": 1, "c.14002C>T": 1}}	\N
5933320	5927084	c.6742C>T/Reference	{"RYR1": {"Reference": 1, "c.6742C>T": 1}}	\N
5933321	5927084	c.526G>A/c.4024A>G	{"RYR1": {"c.526G>A": 1, "c.4024A>G": 1}}	\N
5933322	5927084	c.8327C>T/c.11953T>C	{"RYR1": {"c.8327C>T": 1, "c.11953T>C": 1}}	\N
5933323	5927084	c.7528T>C/c.14168G>A	{"RYR1": {"c.7528T>C": 1, "c.14168G>A": 1}}	\N
5933324	5927084	c.9152G>A/c.10100A>G	{"RYR1": {"c.9152G>A": 1, "c.10100A>G": 1}}	\N
5933325	5927084	c.2797G>A/c.2996G>A	{"RYR1": {"c.2797G>A": 1, "c.2996G>A": 1}}	\N
5933326	5927084	c.10616G>A/c.11953T>C	{"RYR1": {"c.10616G>A": 1, "c.11953T>C": 1}}	\N
5933327	5927084	c.5317C>T/c.11813G>A	{"RYR1": {"c.5317C>T": 1, "c.11813G>A": 1}}	\N
5933328	5927084	c.51_53del/c.11266C>G	{"RYR1": {"c.11266C>G": 1, "c.51_53del": 1}}	\N
5933329	5927084	c.1553T>C/c.6961A>G	{"RYR1": {"c.1553T>C": 1, "c.6961A>G": 1}}	\N
5933330	5927084	c.7317G>C/c.8360C>G	{"RYR1": {"c.7317G>C": 1, "c.8360C>G": 1}}	\N
5933331	5927084	c.8600T>A/c.12884C>T	{"RYR1": {"c.8600T>A": 1, "c.12884C>T": 1}}	\N
5933332	5927084	c.4024A>G/c.14186A>C	{"RYR1": {"c.4024A>G": 1, "c.14186A>C": 1}}	\N
5933333	5927084	c.5132A>G/c.10747G>C	{"RYR1": {"c.5132A>G": 1, "c.10747G>C": 1}}	\N
5933334	5927084	c.2797G>A/c.7787C>T	{"RYR1": {"c.2797G>A": 1, "c.7787C>T": 1}}	\N
5933335	5927084	c.13760C>T/c.14168G>A	{"RYR1": {"c.13760C>T": 1, "c.14168G>A": 1}}	\N
5933336	5927084	c.418G>A/c.7777C>G	{"RYR1": {"c.418G>A": 1, "c.7777C>G": 1}}	\N
5933337	5927084	c.12121C>T/Reference	{"RYR1": {"Reference": 1, "c.12121C>T": 1}}	\N
5933338	5927084	c.1100G>T/c.4024A>G	{"RYR1": {"c.1100G>T": 1, "c.4024A>G": 1}}	\N
5933339	5927084	c.9635A>G/c.10097G>A	{"RYR1": {"c.9635A>G": 1, "c.10097G>A": 1}}	\N
5933340	5927084	c.10100A>G/c.12064A>G	{"RYR1": {"c.10100A>G": 1, "c.12064A>G": 1}}	\N
5933341	5927084	c.1553T>C/c.5317C>T	{"RYR1": {"c.1553T>C": 1, "c.5317C>T": 1}}	\N
5933342	5927084	c.8926C>T/c.11266C>G	{"RYR1": {"c.8926C>T": 1, "c.11266C>G": 1}}	\N
5933343	5927084	c.12881C>T/c.14051T>C	{"RYR1": {"c.12881C>T": 1, "c.14051T>C": 1}}	\N
5933344	5927084	c.1834G>C/c.7816T>A	{"RYR1": {"c.1834G>C": 1, "c.7816T>A": 1}}	\N
5933345	5927084	c.11798A>G/c.12532G>A	{"RYR1": {"c.11798A>G": 1, "c.12532G>A": 1}}	\N
5933346	5927084	c.528G>T/c.6961A>G	{"RYR1": {"c.528G>T": 1, "c.6961A>G": 1}}	\N
5933347	5927084	c.6388G>A/c.10100A>G	{"RYR1": {"c.6388G>A": 1, "c.10100A>G": 1}}	\N
5933348	5927084	c.3127C>T/c.7025A>G	{"RYR1": {"c.3127C>T": 1, "c.7025A>G": 1}}	\N
5933349	5927084	c.9152G>A/c.10097G>A	{"RYR1": {"c.9152G>A": 1, "c.10097G>A": 1}}	\N
5933350	5927084	c.6670C>T/c.11314C>T	{"RYR1": {"c.6670C>T": 1, "c.11314C>T": 1}}	\N
5933351	5927084	c.1209C>G/c.6961A>G	{"RYR1": {"c.1209C>G": 1, "c.6961A>G": 1}}	\N
5933352	5927084	c.2797G>A/c.9797T>C	{"RYR1": {"c.2797G>A": 1, "c.9797T>C": 1}}	\N
5933353	5927084	c.4711A>G/c.13505A>G	{"RYR1": {"c.4711A>G": 1, "c.13505A>G": 1}}	\N
5933354	5927084	c.652G>A/c.13513G>C	{"RYR1": {"c.652G>A": 1, "c.13513G>C": 1}}	\N
5933355	5927084	c.8054C>T/c.10616G>A	{"RYR1": {"c.8054C>T": 1, "c.10616G>A": 1}}	\N
5933356	5927084	c.1201C>A/c.4711A>G	{"RYR1": {"c.1201C>A": 1, "c.4711A>G": 1}}	\N
5933357	5927084	c.2537C>T/c.4024A>G	{"RYR1": {"c.2537C>T": 1, "c.4024A>G": 1}}	\N
5933358	5927084	c.4178A>G/c.11132C>T	{"RYR1": {"c.4178A>G": 1, "c.11132C>T": 1}}	\N
5933359	5927084	c.2050G>C/c.6178G>T	{"RYR1": {"c.2050G>C": 1, "c.6178G>T": 1}}	\N
5933360	5927084	c.10747G>C/c.14449A>T	{"RYR1": {"c.10747G>C": 1, "c.14449A>T": 1}}	\N
5933361	5927084	c.4711A>G/c.6743G>A	{"RYR1": {"c.4711A>G": 1, "c.6743G>A": 1}}	\N
5933362	5927084	c.992_994dup/c.14510delA	{"RYR1": {"c.14510delA": 1, "c.992_994dup": 1}}	\N
5933363	5927084	c.4024A>G/c.14471T>C	{"RYR1": {"c.4024A>G": 1, "c.14471T>C": 1}}	\N
5933364	5927084	c.7292A>T/Reference	{"RYR1": {"Reference": 1, "c.7292A>T": 1}}	\N
5933365	5927084	c.5024T>C/c.10747G>C	{"RYR1": {"c.5024T>C": 1, "c.10747G>C": 1}}	\N
5933366	5927084	c.4024A>G/c.6635T>A	{"RYR1": {"c.4024A>G": 1, "c.6635T>A": 1}}	\N
5933367	5927084	c.10747G>C/c.14693T>C	{"RYR1": {"c.10747G>C": 1, "c.14693T>C": 1}}	\N
5933368	5927084	c.7018T>C/c.8327C>T	{"RYR1": {"c.7018T>C": 1, "c.8327C>T": 1}}	\N
5933369	5927084	c.4024A>G/c.7073T>A	{"RYR1": {"c.4024A>G": 1, "c.7073T>A": 1}}	\N
5933370	5927084	c.6599C>T/c.11798A>G	{"RYR1": {"c.6599C>T": 1, "c.11798A>G": 1}}	\N
5933371	5927084	c.4711A>G/c.14364+1G>T	{"RYR1": {"c.4711A>G": 1, "c.14364+1G>T": 1}}	\N
5933372	5927084	c.7355G>A/c.10747G>C	{"RYR1": {"c.7355G>A": 1, "c.10747G>C": 1}}	\N
5933373	5927084	c.7075C>T/c.10616G>A	{"RYR1": {"c.7075C>T": 1, "c.10616G>A": 1}}	\N
5933374	5927084	c.4178A>G/c.13702C>G	{"RYR1": {"c.4178A>G": 1, "c.13702C>G": 1}}	\N
5933375	5927084	c.493G>A/c.7025A>G	{"RYR1": {"c.493G>A": 1, "c.7025A>G": 1}}	\N
5933376	5927084	c.6670C>T/c.14002C>T	{"RYR1": {"c.6670C>T": 1, "c.14002C>T": 1}}	\N
5933377	5927084	c.6670C>T/c.13918A>G	{"RYR1": {"c.6670C>T": 1, "c.13918A>G": 1}}	\N
5933378	5927084	c.10097G>A/c.14422_14423delinsAA	{"RYR1": {"c.10097G>A": 1, "c.14422_14423delinsAA": 1}}	\N
5933379	5927084	c.7317G>C/c.12310G>C	{"RYR1": {"c.7317G>C": 1, "c.12310G>C": 1}}	\N
5933380	5927084	c.4178A>G/c.14201G>A	{"RYR1": {"c.4178A>G": 1, "c.14201G>A": 1}}	\N
5933381	5927084	c.7025A>G/c.11086G>C	{"RYR1": {"c.7025A>G": 1, "c.11086G>C": 1}}	\N
5933382	5927084	c.1144C>A/c.4711A>G	{"RYR1": {"c.1144C>A": 1, "c.4711A>G": 1}}	\N
5933383	5927084	c.3166G>A/c.8360C>G	{"RYR1": {"c.3166G>A": 1, "c.8360C>G": 1}}	\N
5933384	5927084	c.641C>T/c.11798A>G	{"RYR1": {"c.641C>T": 1, "c.11798A>G": 1}}	\N
5933385	5927084	c.12310G>C/c.12532G>A	{"RYR1": {"c.12310G>C": 1, "c.12532G>A": 1}}	\N
5933386	5927084	c.178G>A/c.10616G>A	{"RYR1": {"c.178G>A": 1, "c.10616G>A": 1}}	\N
5933387	5927084	c.178G>A/c.5317C>T	{"RYR1": {"c.178G>A": 1, "c.5317C>T": 1}}	\N
5933388	5927084	c.9868G>A/Reference	{"RYR1": {"Reference": 1, "c.9868G>A": 1}}	\N
5933389	5927084	c.5440A>G/c.11798A>G	{"RYR1": {"c.5440A>G": 1, "c.11798A>G": 1}}	\N
5933390	5927084	c.2654G>A/c.12406C>A	{"RYR1": {"c.2654G>A": 1, "c.12406C>A": 1}}	\N
5933391	5927084	c.8290G>A/c.12406C>A	{"RYR1": {"c.8290G>A": 1, "c.12406C>A": 1}}	\N
5933392	5927084	c.7025A>G/c.11958C>G	{"RYR1": {"c.7025A>G": 1, "c.11958C>G": 1}}	\N
5933393	5927084	c.652G>A/c.11798A>G	{"RYR1": {"c.652G>A": 1, "c.11798A>G": 1}}	\N
5933394	5927084	c.10747G>C/c.14825G>T	{"RYR1": {"c.10747G>C": 1, "c.14825G>T": 1}}	\N
5933395	5927084	c.2447C>T/c.7760A>G	{"RYR1": {"c.2447C>T": 1, "c.7760A>G": 1}}	\N
5933396	5927084	c.3172G>A/c.14168G>A	{"RYR1": {"c.3172G>A": 1, "c.14168G>A": 1}}	\N
5933397	5927084	c.7292A>T/c.14168G>A	{"RYR1": {"c.7292A>T": 1, "c.14168G>A": 1}}	\N
5933398	5927084	c.4178A>G/c.9850T>A	{"RYR1": {"c.4178A>G": 1, "c.9850T>A": 1}}	\N
5933399	5927084	c.7025A>G/c.11723A>T	{"RYR1": {"c.7025A>G": 1, "c.11723A>T": 1}}	\N
5933400	5927084	c.6670C>T/c.9152G>A	{"RYR1": {"c.6670C>T": 1, "c.9152G>A": 1}}	\N
5933401	5927084	c.12881C>T/c.14002C>T	{"RYR1": {"c.12881C>T": 1, "c.14002C>T": 1}}	\N
5933402	5927084	c.8654C>G/c.13513G>C	{"RYR1": {"c.8654C>G": 1, "c.13513G>C": 1}}	\N
5933403	5927084	c.5441T>A/c.8327C>T	{"RYR1": {"c.5441T>A": 1, "c.8327C>T": 1}}	\N
5933404	5927084	c.8360C>G/c.10556C>T	{"RYR1": {"c.8360C>G": 1, "c.10556C>T": 1}}	\N
5933405	5927084	c.6178G>T/c.14364+1G>T	{"RYR1": {"c.6178G>T": 1, "c.14364+1G>T": 1}}	\N
5933406	5927084	c.7355G>C/c.10747G>C	{"RYR1": {"c.7355G>C": 1, "c.10747G>C": 1}}	\N
5933407	5927084	c.12884C>T/c.14051T>C	{"RYR1": {"c.12884C>T": 1, "c.14051T>C": 1}}	\N
5933408	5927084	c.6178G>T/c.10252A>G	{"RYR1": {"c.6178G>T": 1, "c.10252A>G": 1}}	\N
5933409	5927084	c.10100A>G/c.13913G>A	{"RYR1": {"c.10100A>G": 1, "c.13913G>A": 1}}	\N
5933410	5927084	c.12406C>A/c.13990T>C	{"RYR1": {"c.12406C>A": 1, "c.13990T>C": 1}}	\N
5933411	5927084	c.8654C>G/c.11798A>G	{"RYR1": {"c.8654C>G": 1, "c.11798A>G": 1}}	\N
5933412	5927084	c.1553T>C/c.7025A>G	{"RYR1": {"c.1553T>C": 1, "c.7025A>G": 1}}	\N
5933413	5927084	c.5360C>T/c.9152G>A	{"RYR1": {"c.5360C>T": 1, "c.9152G>A": 1}}	\N
5933414	5927084	c.6961A>G/c.8005G>A	{"RYR1": {"c.6961A>G": 1, "c.8005G>A": 1}}	\N
5933415	5927084	c.8005G>A/c.10747G>C	{"RYR1": {"c.8005G>A": 1, "c.10747G>C": 1}}	\N
5933416	5927084	c.9152G>A/c.14168G>A	{"RYR1": {"c.9152G>A": 1, "c.14168G>A": 1}}	\N
5933417	5927084	c.3224G>A/c.12553G>A	{"RYR1": {"c.3224G>A": 1, "c.12553G>A": 1}}	\N
5933418	5927084	c.5186T>G/c.12310G>C	{"RYR1": {"c.5186T>G": 1, "c.12310G>C": 1}}	\N
5933419	5927084	c.625G>A/c.11798A>G	{"RYR1": {"c.625G>A": 1, "c.11798A>G": 1}}	\N
5933420	5927084	c.131G>A/c.10747G>C	{"RYR1": {"c.131G>A": 1, "c.10747G>C": 1}}	\N
5933421	5927084	c.3224G>A/c.9499C>T	{"RYR1": {"c.3224G>A": 1, "c.9499C>T": 1}}	\N
5933422	5927084	c.5132A>G/c.10100A>G	{"RYR1": {"c.5132A>G": 1, "c.10100A>G": 1}}	\N
5933423	5927084	c.4024A>G/c.7097C>G	{"RYR1": {"c.4024A>G": 1, "c.7097C>G": 1}}	\N
5933424	5927084	c.1459C>G/c.4178A>G	{"RYR1": {"c.1459C>G": 1, "c.4178A>G": 1}}	\N
5933425	5927084	c.1834G>C/c.11266C>G	{"RYR1": {"c.1834G>C": 1, "c.11266C>G": 1}}	\N
5933426	5927084	c.418G>A/c.7097C>G	{"RYR1": {"c.418G>A": 1, "c.7097C>G": 1}}	\N
5933427	5927084	c.6302T>A/c.10100A>G	{"RYR1": {"c.6302T>A": 1, "c.10100A>G": 1}}	\N
5933428	5927084	c.51_53del/c.8327C>T	{"RYR1": {"c.8327C>T": 1, "c.51_53del": 1}}	\N
5933429	5927084	c.526G>A/c.5036G>A	{"RYR1": {"c.526G>A": 1, "c.5036G>A": 1}}	\N
5933430	5927084	c.479A>G/c.13513G>C	{"RYR1": {"c.479A>G": 1, "c.13513G>C": 1}}	\N
5933431	5927084	c.5317C>T/c.5890C>T	{"RYR1": {"c.5317C>T": 1, "c.5890C>T": 1}}	\N
5933432	5927084	c.418G>A/c.14364+1G>T	{"RYR1": {"c.418G>A": 1, "c.14364+1G>T": 1}}	\N
5933433	5927084	c.2924G>A/c.6178G>T	{"RYR1": {"c.2924G>A": 1, "c.6178G>T": 1}}	\N
5933434	5927084	c.10229C>A/c.11798A>G	{"RYR1": {"c.10229C>A": 1, "c.11798A>G": 1}}	\N
5933435	5927084	c.10750G>C/c.14168G>A	{"RYR1": {"c.10750G>C": 1, "c.14168G>A": 1}}	\N
5933436	5927084	c.418G>A/c.467G>A	{"RYR1": {"c.418G>A": 1, "c.467G>A": 1}}	\N
5933437	5927084	c.11947C>T/c.14510delA	{"RYR1": {"c.11947C>T": 1, "c.14510delA": 1}}	\N
5933438	5927084	c.5317C>T/c.7032G>C	{"RYR1": {"c.5317C>T": 1, "c.7032G>C": 1}}	\N
5933439	5927084	c.11416G>A/c.14510delA	{"RYR1": {"c.11416G>A": 1, "c.14510delA": 1}}	\N
5933440	5927084	c.7787C>T/c.7816T>A	{"RYR1": {"c.7787C>T": 1, "c.7816T>A": 1}}	\N
5933441	5927084	c.10229C>A/c.13513G>C	{"RYR1": {"c.10229C>A": 1, "c.13513G>C": 1}}	\N
5933442	5927084	c.7025A>G/c.14678G>A	{"RYR1": {"c.7025A>G": 1, "c.14678G>A": 1}}	\N
5933443	5927084	c.3172G>A/Reference	{"RYR1": {"Reference": 1, "c.3172G>A": 1}}	\N
5933444	5927084	c.3166G>A/c.12310G>C	{"RYR1": {"c.3166G>A": 1, "c.12310G>C": 1}}	\N
5933445	5927084	c.3224G>A/c.12413T>C	{"RYR1": {"c.3224G>A": 1, "c.12413T>C": 1}}	\N
5933446	5927084	c.212C>A/c.10100A>G	{"RYR1": {"c.212C>A": 1, "c.10100A>G": 1}}	\N
5933447	5927084	c.251C>T/c.10616G>A	{"RYR1": {"c.251C>T": 1, "c.10616G>A": 1}}	\N
5933448	5927084	c.8360C>G/c.11126C>T	{"RYR1": {"c.8360C>G": 1, "c.11126C>T": 1}}	\N
5933449	5927084	c.5317C>T/c.14879T>A	{"RYR1": {"c.5317C>T": 1, "c.14879T>A": 1}}	\N
5933450	5927084	c.2447C>T/c.11813G>A	{"RYR1": {"c.2447C>T": 1, "c.11813G>A": 1}}	\N
5933451	5927084	c.5317C>T/c.8926C>T	{"RYR1": {"c.5317C>T": 1, "c.8926C>T": 1}}	\N
5933452	5927084	c.418G>A/c.10252A>G	{"RYR1": {"c.418G>A": 1, "c.10252A>G": 1}}	\N
5933453	5927084	c.14168G>A/c.14817C>A	{"RYR1": {"c.14168G>A": 1, "c.14817C>A": 1}}	\N
5933454	5927084	c.8198G>A/c.14510delA	{"RYR1": {"c.8198G>A": 1, "c.14510delA": 1}}	\N
5933455	5927084	c.455C>A/c.10616G>A	{"RYR1": {"c.455C>A": 1, "c.10616G>A": 1}}	\N
5933456	5927084	c.7771C>G/c.10747G>C	{"RYR1": {"c.7771C>G": 1, "c.10747G>C": 1}}	\N
5933457	5927084	c.12242C>T/c.12881C>T	{"RYR1": {"c.12242C>T": 1, "c.12881C>T": 1}}	\N
5933458	5927084	c.5441T>A/c.12881C>T	{"RYR1": {"c.5441T>A": 1, "c.12881C>T": 1}}	\N
5933459	5927084	c.7528T>C/c.11798A>G	{"RYR1": {"c.7528T>C": 1, "c.11798A>G": 1}}	\N
5933460	5927084	c.8005G>A/c.11798A>G	{"RYR1": {"c.8005G>A": 1, "c.11798A>G": 1}}	\N
5933461	5927084	c.131G>A/c.10100A>G	{"RYR1": {"c.131G>A": 1, "c.10100A>G": 1}}	\N
5933462	5927084	c.8189A>G/c.11266C>G	{"RYR1": {"c.8189A>G": 1, "c.11266C>G": 1}}	\N
5933463	5927084	c.8518C>T/c.10100A>G	{"RYR1": {"c.8518C>T": 1, "c.10100A>G": 1}}	\N
5933464	5927084	c.5360C>T/c.6548G>A	{"RYR1": {"c.5360C>T": 1, "c.6548G>A": 1}}	\N
5933465	5927084	c.8638G>A/c.12881C>T	{"RYR1": {"c.8638G>A": 1, "c.12881C>T": 1}}	\N
5933466	5927084	c.2122G>A/c.7025A>G	{"RYR1": {"c.2122G>A": 1, "c.7025A>G": 1}}	\N
5933467	5927084	c.14168G>A/c.14782A>G	{"RYR1": {"c.14168G>A": 1, "c.14782A>G": 1}}	\N
5933468	5927084	c.7385C>T/c.14168G>A	{"RYR1": {"c.7385C>T": 1, "c.14168G>A": 1}}	\N
5933469	5927084	c.152C>A/c.4178A>G	{"RYR1": {"c.152C>A": 1, "c.4178A>G": 1}}	\N
5933470	5927084	c.7816T>A/c.14364+1G>T	{"RYR1": {"c.7816T>A": 1, "c.14364+1G>T": 1}}	\N
5933471	5927084	c.641C>T/c.12310G>C	{"RYR1": {"c.641C>T": 1, "c.12310G>C": 1}}	\N
5933472	5927084	c.3095G>A/c.8360C>G	{"RYR1": {"c.3095G>A": 1, "c.8360C>G": 1}}	\N
5933473	5927084	c.10747G>C/c.12115A>T	{"RYR1": {"c.10747G>C": 1, "c.12115A>T": 1}}	\N
5933474	5927084	c.641C>T/c.8360C>G	{"RYR1": {"c.641C>T": 1, "c.8360C>G": 1}}	\N
5933475	5927084	c.3667G>A/c.10100A>G	{"RYR1": {"c.3667G>A": 1, "c.10100A>G": 1}}	\N
5933476	5927084	c.7778G>A/c.14168G>A	{"RYR1": {"c.7778G>A": 1, "c.14168G>A": 1}}	\N
5933477	5927084	c.212C>A/c.10097G>A	{"RYR1": {"c.212C>A": 1, "c.10097G>A": 1}}	\N
5933478	5927084	c.11518G>A/c.14168G>A	{"RYR1": {"c.11518G>A": 1, "c.14168G>A": 1}}	\N
5933479	5927084	c.14051T>C/c.14168G>A	{"RYR1": {"c.14051T>C": 1, "c.14168G>A": 1}}	\N
5933480	5927084	c.6961A>G/c.9848G>A	{"RYR1": {"c.6961A>G": 1, "c.9848G>A": 1}}	\N
5933481	5927084	c.3095G>A/c.12310G>C	{"RYR1": {"c.3095G>A": 1, "c.12310G>C": 1}}	\N
5933482	5927084	c.3667G>A/c.8360C>G	{"RYR1": {"c.3667G>A": 1, "c.8360C>G": 1}}	\N
5933483	5927084	c.4024A>G/c.6544A>T	{"RYR1": {"c.4024A>G": 1, "c.6544A>T": 1}}	\N
5933484	5927084	c.947G>T/Reference	{"RYR1": {"c.947G>T": 1, "Reference": 1}}	\N
5933485	5927084	c.2797G>A/c.5132A>G	{"RYR1": {"c.2797G>A": 1, "c.5132A>G": 1}}	\N
5933486	5927084	c.2797G>A/c.7879G>A	{"RYR1": {"c.2797G>A": 1, "c.7879G>A": 1}}	\N
5933487	5927084	c.2447C>T/c.10042C>T	{"RYR1": {"c.2447C>T": 1, "c.10042C>T": 1}}	\N
5933488	5927084	c.5317C>T/c.12383C>T	{"RYR1": {"c.5317C>T": 1, "c.12383C>T": 1}}	\N
5933489	5927084	c.3224G>A/c.8188G>C	{"RYR1": {"c.3224G>A": 1, "c.8188G>C": 1}}	\N
5933490	5927084	c.2447C>T/c.6599C>T	{"RYR1": {"c.2447C>T": 1, "c.6599C>T": 1}}	\N
5933491	5927084	c.6961A>G/c.15060G>C	{"RYR1": {"c.6961A>G": 1, "c.15060G>C": 1}}	\N
5933492	5927084	c.152C>A/c.10747G>C	{"RYR1": {"c.152C>A": 1, "c.10747G>C": 1}}	\N
5933493	5927084	c.2447C>T/c.14186A>C	{"RYR1": {"c.2447C>T": 1, "c.14186A>C": 1}}	\N
5933494	5927084	c.11798A>G/c.14422_14423delinsAA	{"RYR1": {"c.11798A>G": 1, "c.14422_14423delinsAA": 1}}	\N
5933495	5927084	c.1209C>G/c.5317C>T	{"RYR1": {"c.1209C>G": 1, "c.5317C>T": 1}}	\N
5933496	5927084	c.7018T>C/c.12881C>T	{"RYR1": {"c.7018T>C": 1, "c.12881C>T": 1}}	\N
5933497	5927084	c.5132A>G/c.13513G>C	{"RYR1": {"c.5132A>G": 1, "c.13513G>C": 1}}	\N
5933498	5927084	c.7099G>A/Reference	{"RYR1": {"Reference": 1, "c.7099G>A": 1}}	\N
5933499	5927084	c.7760A>G/c.11266C>G	{"RYR1": {"c.7760A>G": 1, "c.11266C>G": 1}}	\N
5933500	5927084	c.12310G>C/c.14197T>G	{"RYR1": {"c.12310G>C": 1, "c.14197T>G": 1}}	\N
5933501	5927084	c.1460T>C/c.13513G>C	{"RYR1": {"c.1460T>C": 1, "c.13513G>C": 1}}	\N
5933502	5927084	c.14424C>A/Reference	{"RYR1": {"Reference": 1, "c.14424C>A": 1}}	\N
5933503	5927084	c.6670C>T/c.12848A>T	{"RYR1": {"c.6670C>T": 1, "c.12848A>T": 1}}	\N
5933504	5927084	c.418G>A/c.8926C>T	{"RYR1": {"c.418G>A": 1, "c.8926C>T": 1}}	\N
5933505	5927084	c.10100A>G/c.14814C>G	{"RYR1": {"c.10100A>G": 1, "c.14814C>G": 1}}	\N
5933506	5927084	c.3166G>A/c.14168G>A	{"RYR1": {"c.3166G>A": 1, "c.14168G>A": 1}}	\N
5933507	5927084	c.6670C>T/c.14424C>A	{"RYR1": {"c.6670C>T": 1, "c.14424C>A": 1}}	\N
5933508	5927084	c.677T>A/c.5317C>T	{"RYR1": {"c.677T>A": 1, "c.5317C>T": 1}}	\N
5933509	5927084	c.10100A>G/c.13672C>T	{"RYR1": {"c.10100A>G": 1, "c.13672C>T": 1}}	\N
5933510	5927084	c.488G>A/c.11798A>G	{"RYR1": {"c.488G>A": 1, "c.11798A>G": 1}}	\N
5933511	5927084	c.12115A>T/c.12884C>T	{"RYR1": {"c.12115A>T": 1, "c.12884C>T": 1}}	\N
5933512	5927084	c.8188G>C/c.10097G>A	{"RYR1": {"c.8188G>C": 1, "c.10097G>A": 1}}	\N
5933513	5927084	c.11798A>G/c.14558C>T	{"RYR1": {"c.11798A>G": 1, "c.14558C>T": 1}}	\N
5933514	5927084	c.10616G>A/c.11314C>T	{"RYR1": {"c.10616G>A": 1, "c.11314C>T": 1}}	\N
5933515	5927084	c.418G>A/c.5890C>T	{"RYR1": {"c.418G>A": 1, "c.5890C>T": 1}}	\N
5933516	5927084	c.7075C>T/c.12884C>T	{"RYR1": {"c.7075C>T": 1, "c.12884C>T": 1}}	\N
5933517	5927084	c.9652G>A/Reference	{"RYR1": {"Reference": 1, "c.9652G>A": 1}}	\N
5933518	5927084	c.2797G>A/c.11947C>T	{"RYR1": {"c.2797G>A": 1, "c.11947C>T": 1}}	\N
5933519	5927084	c.7879G>A/c.10097G>A	{"RYR1": {"c.7879G>A": 1, "c.10097G>A": 1}}	\N
5933520	5927084	c.4400A>G/c.14168G>A	{"RYR1": {"c.4400A>G": 1, "c.14168G>A": 1}}	\N
5933521	5927084	c.4178A>G/c.8729C>T	{"RYR1": {"c.4178A>G": 1, "c.8729C>T": 1}}	\N
5933522	5927084	c.6961A>G/c.11120G>T	{"RYR1": {"c.6961A>G": 1, "c.11120G>T": 1}}	\N
5933523	5927084	c.10750G>C/Reference	{"RYR1": {"Reference": 1, "c.10750G>C": 1}}	\N
5933524	5927084	c.7085A>G/c.10747G>C	{"RYR1": {"c.7085A>G": 1, "c.10747G>C": 1}}	\N
5933525	5927084	c.1475G>A/c.4024A>G	{"RYR1": {"c.1475G>A": 1, "c.4024A>G": 1}}	\N
5933526	5927084	c.5317C>T/c.5341T>C	{"RYR1": {"c.5317C>T": 1, "c.5341T>C": 1}}	\N
5933527	5927084	c.12532G>A/c.13513G>C	{"RYR1": {"c.12532G>A": 1, "c.13513G>C": 1}}	\N
5933528	5927084	c.212C>A/c.2447C>T	{"RYR1": {"c.212C>A": 1, "c.2447C>T": 1}}	\N
5933529	5927084	c.8518C>T/c.12310G>C	{"RYR1": {"c.8518C>T": 1, "c.12310G>C": 1}}	\N
5933530	5927084	c.5317C>T/c.9635A>G	{"RYR1": {"c.5317C>T": 1, "c.9635A>G": 1}}	\N
5933531	5927084	c.1201C>G/c.4711A>G	{"RYR1": {"c.1201C>G": 1, "c.4711A>G": 1}}	\N
5933532	5927084	c.10237A>T/c.12310G>C	{"RYR1": {"c.10237A>T": 1, "c.12310G>C": 1}}	\N
5933533	5927084	c.6388G>A/c.14168G>A	{"RYR1": {"c.6388G>A": 1, "c.14168G>A": 1}}	\N
5933534	5927084	c.6961A>G/c.15059G>C	{"RYR1": {"c.6961A>G": 1, "c.15059G>C": 1}}	\N
5933535	5927084	c.8327C>T/c.13702C>G	{"RYR1": {"c.8327C>T": 1, "c.13702C>G": 1}}	\N
5933536	5927084	c.455C>A/c.6961A>G	{"RYR1": {"c.455C>A": 1, "c.6961A>G": 1}}	\N
5933537	5927084	c.7317G>C/c.10097G>A	{"RYR1": {"c.7317G>C": 1, "c.10097G>A": 1}}	\N
5933538	5927084	c.9356G>A/c.10747G>C	{"RYR1": {"c.9356G>A": 1, "c.10747G>C": 1}}	\N
5933539	5927084	c.6670C>T/c.10891G>T	{"RYR1": {"c.6670C>T": 1, "c.10891G>T": 1}}	\N
5933540	5927084	c.10891G>T/c.11266C>G	{"RYR1": {"c.10891G>T": 1, "c.11266C>G": 1}}	\N
5933541	5927084	c.1453A>G/c.3224G>A	{"RYR1": {"c.1453A>G": 1, "c.3224G>A": 1}}	\N
5933542	5927084	c.3095G>A/c.10097G>A	{"RYR1": {"c.3095G>A": 1, "c.10097G>A": 1}}	\N
5933543	5927084	c.2447C>T/c.7032G>C	{"RYR1": {"c.2447C>T": 1, "c.7032G>C": 1}}	\N
5933544	5927084	c.418G>A/c.8290G>A	{"RYR1": {"c.418G>A": 1, "c.8290G>A": 1}}	\N
5933545	5927084	c.190T>C/c.12881C>T	{"RYR1": {"c.190T>C": 1, "c.12881C>T": 1}}	\N
5933546	5927084	c.2797G>A/c.7522C>G	{"RYR1": {"c.2797G>A": 1, "c.7522C>G": 1}}	\N
5933547	5927084	c.533A>C/c.13513G>C	{"RYR1": {"c.533A>C": 1, "c.13513G>C": 1}}	\N
5933548	5927084	c.4747C>T/c.10097G>A	{"RYR1": {"c.4747C>T": 1, "c.10097G>A": 1}}	\N
5933549	5927084	c.8327C>T/c.11958C>G	{"RYR1": {"c.8327C>T": 1, "c.11958C>G": 1}}	\N
5933550	5927084	c.641C>T/c.10097G>A	{"RYR1": {"c.641C>T": 1, "c.10097G>A": 1}}	\N
5933551	5927084	c.12383C>T/c.14510delA	{"RYR1": {"c.12383C>T": 1, "c.14510delA": 1}}	\N
5933552	5927084	c.3224G>A/c.7018T>C	{"RYR1": {"c.3224G>A": 1, "c.7018T>C": 1}}	\N
5933553	5927084	c.14693T>C/Reference	{"RYR1": {"Reference": 1, "c.14693T>C": 1}}	\N
5933554	5927084	c.1459C>G/c.14168G>A	{"RYR1": {"c.1459C>G": 1, "c.14168G>A": 1}}	\N
5933555	5927084	c.2797G>A/c.5441T>A	{"RYR1": {"c.2797G>A": 1, "c.5441T>A": 1}}	\N
5933556	5927084	c.7816T>A/c.8638G>A	{"RYR1": {"c.7816T>A": 1, "c.8638G>A": 1}}	\N
5933557	5927084	c.10747G>C/c.12533G>T	{"RYR1": {"c.10747G>C": 1, "c.12533G>T": 1}}	\N
5933558	5927084	c.7879G>A/c.13513G>C	{"RYR1": {"c.7879G>A": 1, "c.13513G>C": 1}}	\N
5933559	5927084	c.12848A>T/c.13513G>C	{"RYR1": {"c.12848A>T": 1, "c.13513G>C": 1}}	\N
5933560	5927084	c.6670C>T/c.14680G>A	{"RYR1": {"c.6670C>T": 1, "c.14680G>A": 1}}	\N
5933561	5927084	c.10097G>A/c.10237A>T	{"RYR1": {"c.10097G>A": 1, "c.10237A>T": 1}}	\N
5933562	5927084	c.5317C>T/c.10043G>A	{"RYR1": {"c.5317C>T": 1, "c.10043G>A": 1}}	\N
5933563	5927084	c.4024A>G/c.11120G>T	{"RYR1": {"c.4024A>G": 1, "c.11120G>T": 1}}	\N
5933564	5927084	c.11518G>A/c.12310G>C	{"RYR1": {"c.11518G>A": 1, "c.12310G>C": 1}}	\N
5933565	5927084	c.12115A>T/c.12406C>A	{"RYR1": {"c.12115A>T": 1, "c.12406C>A": 1}}	\N
5933566	5927084	c.6302T>A/c.10097G>A	{"RYR1": {"c.6302T>A": 1, "c.10097G>A": 1}}	\N
5933567	5927084	c.5317C>T/c.15060G>C	{"RYR1": {"c.5317C>T": 1, "c.15060G>C": 1}}	\N
5933568	5927084	c.3224G>A/c.6544A>T	{"RYR1": {"c.3224G>A": 1, "c.6544A>T": 1}}	\N
5933569	5927084	c.5033A>G/c.7816T>A	{"RYR1": {"c.5033A>G": 1, "c.7816T>A": 1}}	\N
5933570	5927084	c.6548G>A/Reference	{"RYR1": {"Reference": 1, "c.6548G>A": 1}}	\N
5933571	5927084	c.7385C>T/c.12310G>C	{"RYR1": {"c.7385C>T": 1, "c.12310G>C": 1}}	\N
5933572	5927084	c.8189A>G/c.14510delA	{"RYR1": {"c.8189A>G": 1, "c.14510delA": 1}}	\N
5933573	5927084	c.131G>A/c.2447C>T	{"RYR1": {"c.131G>A": 1, "c.2447C>T": 1}}	\N
5933574	5927084	c.7025A>G/c.11953T>C	{"RYR1": {"c.7025A>G": 1, "c.11953T>C": 1}}	\N
5933575	5927084	c.13994_13995delTCinsCT/c.14510delA	{"RYR1": {"c.14510delA": 1, "c.13994_13995delTCinsCT": 1}}	\N
5933576	5927084	c.2447C>T/c.2654G>A	{"RYR1": {"c.2447C>T": 1, "c.2654G>A": 1}}	\N
5933577	5927084	c.455C>A/c.12884C>T	{"RYR1": {"c.455C>A": 1, "c.12884C>T": 1}}	\N
5933578	5927084	c.5132A>G/c.8360C>G	{"RYR1": {"c.5132A>G": 1, "c.8360C>G": 1}}	\N
5933579	5927084	c.4178A>G/c.11126C>T	{"RYR1": {"c.4178A>G": 1, "c.11126C>T": 1}}	\N
5933580	5927084	c.5036G>A/c.9850T>A	{"RYR1": {"c.5036G>A": 1, "c.9850T>A": 1}}	\N
5933581	5927084	c.178G>T/c.5317C>T	{"RYR1": {"c.178G>T": 1, "c.5317C>T": 1}}	\N
5933582	5927084	c.1553T>C/c.5036G>A	{"RYR1": {"c.1553T>C": 1, "c.5036G>A": 1}}	\N
5933583	5927084	c.2447C>T/c.14813T>C	{"RYR1": {"c.2447C>T": 1, "c.14813T>C": 1}}	\N
5933584	5927084	c.12884C>T/c.14270G>A	{"RYR1": {"c.12884C>T": 1, "c.14270G>A": 1}}	\N
5933585	5927084	c.1100G>A/c.4024A>G	{"RYR1": {"c.1100G>A": 1, "c.4024A>G": 1}}	\N
5933586	5927084	c.5132A>G/c.12310G>C	{"RYR1": {"c.5132A>G": 1, "c.12310G>C": 1}}	\N
5933587	5927084	c.479A>G/c.8360C>G	{"RYR1": {"c.479A>G": 1, "c.8360C>G": 1}}	\N
5933588	5927084	c.7816T>A/c.12689T>G	{"RYR1": {"c.7816T>A": 1, "c.12689T>G": 1}}	\N
5933589	5927084	c.4775C>T/c.14510delA	{"RYR1": {"c.4775C>T": 1, "c.14510delA": 1}}	\N
5933590	5927084	c.7112A>G/c.12881C>T	{"RYR1": {"c.7112A>G": 1, "c.12881C>T": 1}}	\N
5933591	5927084	c.2050G>C/c.5360C>T	{"RYR1": {"c.2050G>C": 1, "c.5360C>T": 1}}	\N
5933592	5927084	c.5317C>T/c.11120G>T	{"RYR1": {"c.5317C>T": 1, "c.11120G>T": 1}}	\N
5933593	5927084	c.9499C>T/c.12406C>A	{"RYR1": {"c.9499C>T": 1, "c.12406C>A": 1}}	\N
5933594	5927084	c.12121C>T/c.14168G>A	{"RYR1": {"c.12121C>T": 1, "c.14168G>A": 1}}	\N
5933595	5927084	c.7025A>G/c.11126C>T	{"RYR1": {"c.7025A>G": 1, "c.11126C>T": 1}}	\N
5933596	5927084	c.2797G>A/c.13934G>A	{"RYR1": {"c.2797G>A": 1, "c.13934G>A": 1}}	\N
5933597	5927084	c.5036G>A/c.9152G>A	{"RYR1": {"c.5036G>A": 1, "c.9152G>A": 1}}	\N
5933598	5927084	c.5317C>T/c.15059G>C	{"RYR1": {"c.5317C>T": 1, "c.15059G>C": 1}}	\N
5933599	5927084	c.6961A>G/c.9635A>G	{"RYR1": {"c.6961A>G": 1, "c.9635A>G": 1}}	\N
5933600	5927084	c.10100A>G/c.11416G>A	{"RYR1": {"c.10100A>G": 1, "c.11416G>A": 1}}	\N
5933601	5927084	c.12884C>T/c.14002C>T	{"RYR1": {"c.12884C>T": 1, "c.14002C>T": 1}}	\N
5933602	5927084	c.4400A>G/c.11798A>G	{"RYR1": {"c.4400A>G": 1, "c.11798A>G": 1}}	\N
5933603	5927084	c.1459C>G/c.12310G>C	{"RYR1": {"c.1459C>G": 1, "c.12310G>C": 1}}	\N
5933604	5927084	c.8327C>T/c.9676G>C	{"RYR1": {"c.8327C>T": 1, "c.9676G>C": 1}}	\N
5933605	5927084	c.5317C>T/c.8005G>A	{"RYR1": {"c.5317C>T": 1, "c.8005G>A": 1}}	\N
5933606	5927084	c.10616G>A/c.11723A>T	{"RYR1": {"c.10616G>A": 1, "c.11723A>T": 1}}	\N
5933607	5927084	c.3224G>A/c.7085A>G	{"RYR1": {"c.3224G>A": 1, "c.7085A>G": 1}}	\N
5933608	5927084	c.251C>T/c.5036G>A	{"RYR1": {"c.251C>T": 1, "c.5036G>A": 1}}	\N
5933609	5927084	c.7199A>G/c.7816T>A	{"RYR1": {"c.7199A>G": 1, "c.7816T>A": 1}}	\N
5933610	5927084	c.3224G>A/c.14126C>T	{"RYR1": {"c.3224G>A": 1, "c.14126C>T": 1}}	\N
5933611	5927084	c.9848G>A/c.10747G>C	{"RYR1": {"c.9848G>A": 1, "c.10747G>C": 1}}	\N
5933612	5927084	c.2447C>T/c.6304G>C	{"RYR1": {"c.2447C>T": 1, "c.6304G>C": 1}}	\N
5933613	5927084	c.6388G>A/c.12310G>C	{"RYR1": {"c.6388G>A": 1, "c.12310G>C": 1}}	\N
5933614	5927084	c.3656A>C/c.6961A>G	{"RYR1": {"c.3656A>C": 1, "c.6961A>G": 1}}	\N
5933615	5927084	c.8527T>C/c.13513G>C	{"RYR1": {"c.8527T>C": 1, "c.13513G>C": 1}}	\N
5933616	5927084	c.5360C>T/c.14424C>A	{"RYR1": {"c.5360C>T": 1, "c.14424C>A": 1}}	\N
5933617	5927084	c.8327C>T/c.14581C>T	{"RYR1": {"c.8327C>T": 1, "c.14581C>T": 1}}	\N
5933618	5927084	c.14168G>A/c.14364+1G>T	{"RYR1": {"c.14168G>A": 1, "c.14364+1G>T": 1}}	\N
5933619	5927084	c.4763C>T/c.5036G>A	{"RYR1": {"c.4763C>T": 1, "c.5036G>A": 1}}	\N
5933620	5927084	c.3127C>T/c.5036G>A	{"RYR1": {"c.3127C>T": 1, "c.5036G>A": 1}}	\N
5933621	5927084	c.8327C>T/c.9652G>A	{"RYR1": {"c.8327C>T": 1, "c.9652G>A": 1}}	\N
5933622	5927084	c.10747G>C/c.13760C>T	{"RYR1": {"c.10747G>C": 1, "c.13760C>T": 1}}	\N
5933623	5927084	c.9758T>C/c.12884C>T	{"RYR1": {"c.9758T>C": 1, "c.12884C>T": 1}}	\N
5933624	5927084	c.467G>A/c.2797G>A	{"RYR1": {"c.467G>A": 1, "c.2797G>A": 1}}	\N
5933625	5927084	c.652G>A/c.10097G>A	{"RYR1": {"c.652G>A": 1, "c.10097G>A": 1}}	\N
5933626	5927084	c.641C>T/c.10100A>G	{"RYR1": {"c.641C>T": 1, "c.10100A>G": 1}}	\N
5933627	5927084	c.479A>G/c.12310G>C	{"RYR1": {"c.479A>G": 1, "c.12310G>C": 1}}	\N
5933628	5927084	c.1411C>T/c.5317C>T	{"RYR1": {"c.1411C>T": 1, "c.5317C>T": 1}}	\N
5933629	5927084	c.8327C>T/c.13918A>G	{"RYR1": {"c.8327C>T": 1, "c.13918A>G": 1}}	\N
5933630	5927084	c.3172G>A/c.6670C>T	{"RYR1": {"c.3172G>A": 1, "c.6670C>T": 1}}	\N
5933631	5927084	c.10042C>T/c.11266C>G	{"RYR1": {"c.10042C>T": 1, "c.11266C>G": 1}}	\N
5933632	5927084	c.1024G>A/c.2447C>T	{"RYR1": {"c.1024G>A": 1, "c.2447C>T": 1}}	\N
5933633	5927084	c.4711A>G/c.6478G>A	{"RYR1": {"c.4711A>G": 1, "c.6478G>A": 1}}	\N
5933634	5927084	c.3166G>A/c.6670C>T	{"RYR1": {"c.3166G>A": 1, "c.6670C>T": 1}}	\N
5933635	5927084	c.152C>A/c.11798A>G	{"RYR1": {"c.152C>A": 1, "c.11798A>G": 1}}	\N
5933636	5927084	c.4711A>G/c.14817C>A	{"RYR1": {"c.4711A>G": 1, "c.14817C>A": 1}}	\N
5933637	5927084	c.6388G>A/c.8360C>G	{"RYR1": {"c.6388G>A": 1, "c.8360C>G": 1}}	\N
5933638	5927084	c.2797G>A/c.14002C>T	{"RYR1": {"c.2797G>A": 1, "c.14002C>T": 1}}	\N
5933639	5927084	c.6847A>C/c.12881C>T	{"RYR1": {"c.6847A>C": 1, "c.12881C>T": 1}}	\N
5933640	5927084	c.4400A>G/c.6670C>T	{"RYR1": {"c.4400A>G": 1, "c.6670C>T": 1}}	\N
5933641	5927084	c.9676G>C/c.10747G>C	{"RYR1": {"c.9676G>C": 1, "c.10747G>C": 1}}	\N
5933642	5927084	c.10747G>C/c.12689T>G	{"RYR1": {"c.10747G>C": 1, "c.12689T>G": 1}}	\N
5933643	5927084	c.1460T>C/c.8360C>G	{"RYR1": {"c.1460T>C": 1, "c.8360C>G": 1}}	\N
5933644	5927084	c.1422G>T/c.7025A>G	{"RYR1": {"c.1422G>T": 1, "c.7025A>G": 1}}	\N
5933645	5927084	c.2797G>A/c.14270G>A	{"RYR1": {"c.2797G>A": 1, "c.14270G>A": 1}}	\N
5933646	5927084	c.528G>T/c.5360C>T	{"RYR1": {"c.528G>T": 1, "c.5360C>T": 1}}	\N
5933647	5927084	c.10616G>A/c.12848A>T	{"RYR1": {"c.10616G>A": 1, "c.12848A>T": 1}}	\N
5933648	5927084	c.3166G>A/c.11798A>G	{"RYR1": {"c.3166G>A": 1, "c.11798A>G": 1}}	\N
5933649	5927084	c.418G>A/c.14458G>T	{"RYR1": {"c.418G>A": 1, "c.14458G>T": 1}}	\N
5933650	5927084	c.10097G>A/c.12355A>T	{"RYR1": {"c.10097G>A": 1, "c.12355A>T": 1}}	\N
5933651	5927084	c.12310G>C/c.14818G>A	{"RYR1": {"c.12310G>C": 1, "c.14818G>A": 1}}	\N
5933652	5927084	c.6178G>T/c.12689T>G	{"RYR1": {"c.6178G>T": 1, "c.12689T>G": 1}}	\N
5933653	5927084	c.5360C>T/c.14051T>C	{"RYR1": {"c.5360C>T": 1, "c.14051T>C": 1}}	\N
5933654	5927084	c.7879G>A/c.10100A>G	{"RYR1": {"c.7879G>A": 1, "c.10100A>G": 1}}	\N
5933655	5927084	c.1459C>G/c.8360C>G	{"RYR1": {"c.1459C>G": 1, "c.8360C>G": 1}}	\N
5933656	5927084	c.9152G>A/c.11798A>G	{"RYR1": {"c.9152G>A": 1, "c.11798A>G": 1}}	\N
5933657	5927084	c.11798A>G/c.14509C>G	{"RYR1": {"c.11798A>G": 1, "c.14509C>G": 1}}	\N
5933658	5927084	c.6961A>G/c.14813T>C	{"RYR1": {"c.6961A>G": 1, "c.14813T>C": 1}}	\N
5933659	5927084	c.10252A>G/c.13513G>C	{"RYR1": {"c.10252A>G": 1, "c.13513G>C": 1}}	\N
5933660	5927084	c.2924G>A/c.12406C>A	{"RYR1": {"c.2924G>A": 1, "c.12406C>A": 1}}	\N
5933661	5927084	c.6961A>G/c.10252A>G	{"RYR1": {"c.6961A>G": 1, "c.10252A>G": 1}}	\N
5933662	5927084	c.418G>A/c.14458G>A	{"RYR1": {"c.418G>A": 1, "c.14458G>A": 1}}	\N
5933663	5927084	c.5186T>G/c.10747G>C	{"RYR1": {"c.5186T>G": 1, "c.10747G>C": 1}}	\N
5933664	5927084	c.4178A>G/c.9676G>C	{"RYR1": {"c.4178A>G": 1, "c.9676G>C": 1}}	\N
5933665	5927084	c.3527C>T/c.5036G>A	{"RYR1": {"c.3527C>T": 1, "c.5036G>A": 1}}	\N
5933666	5927084	c.947G>T/c.8327C>T	{"RYR1": {"c.947G>T": 1, "c.8327C>T": 1}}	\N
5933667	5927084	c.533A>C/c.14168G>A	{"RYR1": {"c.533A>C": 1, "c.14168G>A": 1}}	\N
5933668	5927084	c.418G>A/c.3656A>C	{"RYR1": {"c.418G>A": 1, "c.3656A>C": 1}}	\N
5933669	5927084	c.10616G>A/c.14270G>A	{"RYR1": {"c.10616G>A": 1, "c.14270G>A": 1}}	\N
5933670	5927084	c.1834G>C/c.4024A>G	{"RYR1": {"c.1834G>C": 1, "c.4024A>G": 1}}	\N
5933671	5927084	c.6178G>T/c.8926C>T	{"RYR1": {"c.6178G>T": 1, "c.8926C>T": 1}}	\N
5933672	5927084	c.7816T>A/c.8290G>A	{"RYR1": {"c.7816T>A": 1, "c.8290G>A": 1}}	\N
5933673	5927084	c.418G>A/c.14879T>A	{"RYR1": {"c.418G>A": 1, "c.14879T>A": 1}}	\N
5933674	5927084	c.3224G>A/c.8054C>T	{"RYR1": {"c.3224G>A": 1, "c.8054C>T": 1}}	\N
5933675	5927084	c.9356G>A/c.13513G>C	{"RYR1": {"c.9356G>A": 1, "c.13513G>C": 1}}	\N
5933676	5927084	c.131G>A/c.418G>A	{"RYR1": {"c.131G>A": 1, "c.418G>A": 1}}	\N
5933677	5927084	c.5317C>T/c.10252A>G	{"RYR1": {"c.5317C>T": 1, "c.10252A>G": 1}}	\N
5933678	5927084	c.8327C>T/c.11126C>T	{"RYR1": {"c.8327C>T": 1, "c.11126C>T": 1}}	\N
5933679	5927084	c.6961A>G/c.10043G>A	{"RYR1": {"c.6961A>G": 1, "c.10043G>A": 1}}	\N
5933680	5927084	c.3656A>C/c.5317C>T	{"RYR1": {"c.3656A>C": 1, "c.5317C>T": 1}}	\N
5933681	5927084	c.12533G>T/c.12884C>T	{"RYR1": {"c.12533G>T": 1, "c.12884C>T": 1}}	\N
5933682	5927084	c.6640G>A/c.7816T>A	{"RYR1": {"c.6640G>A": 1, "c.7816T>A": 1}}	\N
5933683	5927084	c.418G>A/c.641C>T	{"RYR1": {"c.418G>A": 1, "c.641C>T": 1}}	\N
5933684	5927084	c.190T>C/Reference	{"RYR1": {"c.190T>C": 1, "Reference": 1}}	\N
5933685	5927084	c.7199A>G/c.11266C>G	{"RYR1": {"c.7199A>G": 1, "c.11266C>G": 1}}	\N
5933686	5927084	c.5186T>G/c.10100A>G	{"RYR1": {"c.5186T>G": 1, "c.10100A>G": 1}}	\N
5933687	5927084	c.7760A>G/c.7816T>A	{"RYR1": {"c.7760A>G": 1, "c.7816T>A": 1}}	\N
5933688	5927084	c.9152G>A/c.10747G>C	{"RYR1": {"c.9152G>A": 1, "c.10747G>C": 1}}	\N
5933689	5927084	c.418G>A/c.1201C>A	{"RYR1": {"c.418G>A": 1, "c.1201C>A": 1}}	\N
5933690	5927084	c.11266C>G/c.12355A>T	{"RYR1": {"c.11266C>G": 1, "c.12355A>T": 1}}	\N
5933691	5927084	c.4024A>G/c.12383C>T	{"RYR1": {"c.4024A>G": 1, "c.12383C>T": 1}}	\N
5933692	5927084	c.418G>A/c.1201C>G	{"RYR1": {"c.418G>A": 1, "c.1201C>G": 1}}	\N
5933693	5927084	c.526G>A/c.4711A>G	{"RYR1": {"c.526G>A": 1, "c.4711A>G": 1}}	\N
5933694	5927084	c.6478G>A/c.12884C>T	{"RYR1": {"c.6478G>A": 1, "c.12884C>T": 1}}	\N
5933695	5927084	c.2797G>A/c.5024T>C	{"RYR1": {"c.2797G>A": 1, "c.5024T>C": 1}}	\N
5933696	5927084	c.2447C>T/c.10252A>G	{"RYR1": {"c.2447C>T": 1, "c.10252A>G": 1}}	\N
5933697	5927084	c.1422G>T/c.5036G>A	{"RYR1": {"c.1422G>T": 1, "c.5036G>A": 1}}	\N
5933698	5927084	c.6961A>G/c.7097C>G	{"RYR1": {"c.6961A>G": 1, "c.7097C>G": 1}}	\N
5933699	5927084	c.2447C>T/c.6377G>A	{"RYR1": {"c.2447C>T": 1, "c.6377G>A": 1}}	\N
5933700	5927084	c.1100G>A/c.7816T>A	{"RYR1": {"c.1100G>A": 1, "c.7816T>A": 1}}	\N
5933701	5927084	c.5360C>T/c.7317G>C	{"RYR1": {"c.5360C>T": 1, "c.7317G>C": 1}}	\N
5933702	5927084	c.9652G>A/c.12881C>T	{"RYR1": {"c.9652G>A": 1, "c.12881C>T": 1}}	\N
5933703	5927084	c.7385C>T/c.11798A>G	{"RYR1": {"c.7385C>T": 1, "c.11798A>G": 1}}	\N
5933704	5927084	c.14168G>A/c.14825G>T	{"RYR1": {"c.14168G>A": 1, "c.14825G>T": 1}}	\N
5933705	5927084	c.418G>A/c.2537C>T	{"RYR1": {"c.418G>A": 1, "c.2537C>T": 1}}	\N
5933706	5927084	c.10616G>A/c.14002C>T	{"RYR1": {"c.10616G>A": 1, "c.14002C>T": 1}}	\N
5933707	5927084	c.12532G>A/c.14168G>A	{"RYR1": {"c.12532G>A": 1, "c.14168G>A": 1}}	\N
5933708	5927084	c.12242C>T/Reference	{"RYR1": {"Reference": 1, "c.12242C>T": 1}}	\N
5933709	5927084	c.8290G>A/c.12884C>T	{"RYR1": {"c.8290G>A": 1, "c.12884C>T": 1}}	\N
5933710	5927084	c.3656A>C/c.10616G>A	{"RYR1": {"c.3656A>C": 1, "c.10616G>A": 1}}	\N
5933711	5927084	c.2537C>T/c.7025A>G	{"RYR1": {"c.2537C>T": 1, "c.7025A>G": 1}}	\N
5933712	5927084	c.11266C>G/c.12532G>A	{"RYR1": {"c.11266C>G": 1, "c.12532G>A": 1}}	\N
5933713	5927084	c.1459C>G/c.11798A>G	{"RYR1": {"c.1459C>G": 1, "c.11798A>G": 1}}	\N
5933714	5927084	c.1459C>G/c.13513G>C	{"RYR1": {"c.1459C>G": 1, "c.13513G>C": 1}}	\N
5933715	5927084	c.4711A>G/c.14782A>G	{"RYR1": {"c.4711A>G": 1, "c.14782A>G": 1}}	\N
5933716	5927084	c.4178A>G/c.9652G>A	{"RYR1": {"c.4178A>G": 1, "c.9652G>A": 1}}	\N
5933717	5927084	c.418G>A/c.1100G>T	{"RYR1": {"c.418G>A": 1, "c.1100G>T": 1}}	\N
5933718	5927084	c.7317G>C/c.10100A>G	{"RYR1": {"c.7317G>C": 1, "c.10100A>G": 1}}	\N
5933719	5927084	c.7075C>T/c.12406C>A	{"RYR1": {"c.7075C>T": 1, "c.12406C>A": 1}}	\N
5933720	5927084	c.493G>A/c.4024A>G	{"RYR1": {"c.493G>A": 1, "c.4024A>G": 1}}	\N
5933721	5927084	c.7112A>G/Reference	{"RYR1": {"Reference": 1, "c.7112A>G": 1}}	\N
5933722	5927084	c.9356G>A/c.11798A>G	{"RYR1": {"c.9356G>A": 1, "c.11798A>G": 1}}	\N
5933723	5927084	c.8360C>G/c.13702C>G	{"RYR1": {"c.8360C>G": 1, "c.13702C>G": 1}}	\N
5933724	5927084	c.488G>A/c.12310G>C	{"RYR1": {"c.488G>A": 1, "c.12310G>C": 1}}	\N
5933725	5927084	c.6544A>T/c.7025A>G	{"RYR1": {"c.6544A>T": 1, "c.7025A>G": 1}}	\N
5933726	5927084	c.418G>A/c.13990T>C	{"RYR1": {"c.418G>A": 1, "c.13990T>C": 1}}	\N
5933727	5927084	c.625G>A/c.14168G>A	{"RYR1": {"c.625G>A": 1, "c.14168G>A": 1}}	\N
5933728	5927084	c.418G>A/c.992_994dup	{"RYR1": {"c.418G>A": 1, "c.992_994dup": 1}}	\N
5933729	5927084	c.13513G>C/c.13934G>A	{"RYR1": {"c.13513G>C": 1, "c.13934G>A": 1}}	\N
5933730	5927084	c.4024A>G/c.6599C>T	{"RYR1": {"c.4024A>G": 1, "c.6599C>T": 1}}	\N
5933731	5927084	c.8360C>G/c.13918A>G	{"RYR1": {"c.8360C>G": 1, "c.13918A>G": 1}}	\N
5933732	5927084	c.10252A>G/c.14168G>A	{"RYR1": {"c.10252A>G": 1, "c.14168G>A": 1}}	\N
5933733	5927084	c.10043G>A/c.12406C>A	{"RYR1": {"c.10043G>A": 1, "c.12406C>A": 1}}	\N
5933734	5927084	c.418G>A/c.1100G>A	{"RYR1": {"c.418G>A": 1, "c.1100G>A": 1}}	\N
5933735	5927084	c.1024G>A/c.3224G>A	{"RYR1": {"c.1024G>A": 1, "c.3224G>A": 1}}	\N
5933736	5927084	c.8638G>A/Reference	{"RYR1": {"Reference": 1, "c.8638G>A": 1}}	\N
5933737	5927084	c.652G>A/c.10747G>C	{"RYR1": {"c.652G>A": 1, "c.10747G>C": 1}}	\N
5933738	5927084	c.1460T>C/c.12310G>C	{"RYR1": {"c.1460T>C": 1, "c.12310G>C": 1}}	\N
5933739	5927084	c.9268G>A/c.10616G>A	{"RYR1": {"c.9268G>A": 1, "c.10616G>A": 1}}	\N
5933740	5927084	c.418G>A/c.677T>A	{"RYR1": {"c.418G>A": 1, "c.677T>A": 1}}	\N
5933741	5927084	c.12028G>A/c.13513G>C	{"RYR1": {"c.12028G>A": 1, "c.13513G>C": 1}}	\N
5933742	5927084	c.2797G>A/c.11314C>T	{"RYR1": {"c.2797G>A": 1, "c.11314C>T": 1}}	\N
5933743	5927084	c.6670C>T/c.7787C>T	{"RYR1": {"c.6670C>T": 1, "c.7787C>T": 1}}	\N
5933744	5927084	c.4711A>G/c.7778G>A	{"RYR1": {"c.4711A>G": 1, "c.7778G>A": 1}}	\N
5933745	5927084	c.10097G>A/c.12532G>A	{"RYR1": {"c.10097G>A": 1, "c.12532G>A": 1}}	\N
5933746	5927084	c.8360C>G/c.9850T>A	{"RYR1": {"c.8360C>G": 1, "c.9850T>A": 1}}	\N
5933747	5927084	c.947G>T/c.12881C>T	{"RYR1": {"c.947G>T": 1, "c.12881C>T": 1}}	\N
5933748	5927084	c.10616G>A/c.10891G>T	{"RYR1": {"c.10616G>A": 1, "c.10891G>T": 1}}	\N
5933749	5927084	c.5317C>T/c.6377G>A	{"RYR1": {"c.5317C>T": 1, "c.6377G>A": 1}}	\N
5933750	5927084	c.10747G>C/c.13505A>G	{"RYR1": {"c.10747G>C": 1, "c.13505A>G": 1}}	\N
5933751	5927084	c.493G>A/c.14510delA	{"RYR1": {"c.493G>A": 1, "c.14510delA": 1}}	\N
5933752	5927084	c.4178A>G/c.11086G>C	{"RYR1": {"c.4178A>G": 1, "c.11086G>C": 1}}	\N
5933753	5927084	c.1597C>A/c.11266C>G	{"RYR1": {"c.1597C>A": 1, "c.11266C>G": 1}}	\N
5933754	5927084	c.6599C>T/c.12310G>C	{"RYR1": {"c.6599C>T": 1, "c.12310G>C": 1}}	\N
5933755	5927084	c.8729C>T/c.12406C>A	{"RYR1": {"c.8729C>T": 1, "c.12406C>A": 1}}	\N
5933756	5927084	c.11518G>A/c.13513G>C	{"RYR1": {"c.11518G>A": 1, "c.13513G>C": 1}}	\N
5933757	5927084	c.9649T>C/c.14510delA	{"RYR1": {"c.9649T>C": 1, "c.14510delA": 1}}	\N
5933758	5927084	c.5317C>T/c.7073T>A	{"RYR1": {"c.5317C>T": 1, "c.7073T>A": 1}}	\N
5933759	5927084	c.8654C>G/c.14168G>A	{"RYR1": {"c.8654C>G": 1, "c.14168G>A": 1}}	\N
5933760	5927084	c.7816T>A/c.8926C>T	{"RYR1": {"c.7816T>A": 1, "c.8926C>T": 1}}	\N
5933761	5927084	c.6178G>T/c.8290G>A	{"RYR1": {"c.6178G>T": 1, "c.8290G>A": 1}}	\N
5933762	5927084	c.6961A>G/c.12383C>T	{"RYR1": {"c.6961A>G": 1, "c.12383C>T": 1}}	\N
5933763	5927084	c.12310G>C/c.14422_14423delinsAA	{"RYR1": {"c.12310G>C": 1, "c.14422_14423delinsAA": 1}}	\N
5933764	5927084	c.9676G>C/c.10100A>G	{"RYR1": {"c.9676G>C": 1, "c.10100A>G": 1}}	\N
5933765	5927084	c.131G>A/c.10097G>A	{"RYR1": {"c.131G>A": 1, "c.10097G>A": 1}}	\N
5933766	5927084	c.6178G>T/c.12115A>T	{"RYR1": {"c.6178G>T": 1, "c.12115A>T": 1}}	\N
5933767	5927084	c.7018T>C/Reference	{"RYR1": {"Reference": 1, "c.7018T>C": 1}}	\N
5933768	5927084	c.3224G>A/c.12028G>A	{"RYR1": {"c.3224G>A": 1, "c.12028G>A": 1}}	\N
5933769	5927084	c.178G>A/c.12884C>T	{"RYR1": {"c.178G>A": 1, "c.12884C>T": 1}}	\N
5933770	5927084	c.680A>T/c.11266C>G	{"RYR1": {"c.680A>T": 1, "c.11266C>G": 1}}	\N
5933771	5927084	c.6961A>G/c.7073T>A	{"RYR1": {"c.6961A>G": 1, "c.7073T>A": 1}}	\N
5933772	5927084	c.677T>A/c.12884C>T	{"RYR1": {"c.677T>A": 1, "c.12884C>T": 1}}	\N
5933773	5927084	c.992_994dup/c.11266C>G	{"RYR1": {"c.11266C>G": 1, "c.992_994dup": 1}}	\N
5933774	5927084	c.7879G>A/c.12310G>C	{"RYR1": {"c.7879G>A": 1, "c.12310G>C": 1}}	\N
5933775	5927084	c.3224G>A/c.7099G>A	{"RYR1": {"c.3224G>A": 1, "c.7099G>A": 1}}	\N
5933776	5927084	c.4711A>G/c.14449A>T	{"RYR1": {"c.4711A>G": 1, "c.14449A>T": 1}}	\N
5933777	5927084	c.11798A>G/c.14818G>A	{"RYR1": {"c.11798A>G": 1, "c.14818G>A": 1}}	\N
5933778	5927084	c.4024A>G/c.6037A>C	{"RYR1": {"c.4024A>G": 1, "c.6037A>C": 1}}	\N
5933779	5927084	c.7816T>A/c.14693T>C	{"RYR1": {"c.7816T>A": 1, "c.14693T>C": 1}}	\N
5933780	5927084	c.2924G>A/c.5360C>T	{"RYR1": {"c.2924G>A": 1, "c.5360C>T": 1}}	\N
5933781	5927084	c.3224G>A/c.13913G>A	{"RYR1": {"c.3224G>A": 1, "c.13913G>A": 1}}	\N
5933782	5927084	c.1598G>A/c.12406C>A	{"RYR1": {"c.1598G>A": 1, "c.12406C>A": 1}}	\N
5933783	5927084	c.533A>C/c.6670C>T	{"RYR1": {"c.533A>C": 1, "c.6670C>T": 1}}	\N
5933784	5927084	c.5440A>G/c.14168G>A	{"RYR1": {"c.5440A>G": 1, "c.14168G>A": 1}}	\N
5933785	5927084	c.5036G>A/c.6847A>C	{"RYR1": {"c.5036G>A": 1, "c.6847A>C": 1}}	\N
5933786	5927084	c.3224G>A/c.14471T>C	{"RYR1": {"c.3224G>A": 1, "c.14471T>C": 1}}	\N
5933787	5927084	c.7385C>T/c.13513G>C	{"RYR1": {"c.7385C>T": 1, "c.13513G>C": 1}}	\N
5933788	5927084	c.7771C>T/c.10097G>A	{"RYR1": {"c.7771C>T": 1, "c.10097G>A": 1}}	\N
5933789	5927084	c.7025A>G/c.13918A>G	{"RYR1": {"c.7025A>G": 1, "c.13918A>G": 1}}	\N
5933790	5927084	c.13913G>A/Reference	{"RYR1": {"Reference": 1, "c.13913G>A": 1}}	\N
5933791	5927084	c.4024A>G/c.6304G>C	{"RYR1": {"c.4024A>G": 1, "c.6304G>C": 1}}	\N
5933792	5927084	c.11518G>A/c.11798A>G	{"RYR1": {"c.11518G>A": 1, "c.11798A>G": 1}}	\N
5933793	5927084	c.4711A>G/c.6388G>A	{"RYR1": {"c.4711A>G": 1, "c.6388G>A": 1}}	\N
5933794	5927084	c.8360C>G/c.9152G>A	{"RYR1": {"c.8360C>G": 1, "c.9152G>A": 1}}	\N
5933795	5927084	c.8327C>T/c.10556C>T	{"RYR1": {"c.8327C>T": 1, "c.10556C>T": 1}}	\N
5933796	5927084	c.10616G>A/c.14424C>A	{"RYR1": {"c.10616G>A": 1, "c.14424C>A": 1}}	\N
5933797	5927084	c.1598G>A/c.5360C>T	{"RYR1": {"c.1598G>A": 1, "c.5360C>T": 1}}	\N
5933798	5927084	c.3667G>A/c.10097G>A	{"RYR1": {"c.3667G>A": 1, "c.10097G>A": 1}}	\N
5933799	5927084	c.677T>A/c.6961A>G	{"RYR1": {"c.677T>A": 1, "c.6961A>G": 1}}	\N
5933800	5927084	c.12689T>G/c.13513G>C	{"RYR1": {"c.12689T>G": 1, "c.13513G>C": 1}}	\N
5933801	5927084	c.14168G>A/c.14968A>G	{"RYR1": {"c.14168G>A": 1, "c.14968A>G": 1}}	\N
5933802	5927084	c.479A>G/c.10100A>G	{"RYR1": {"c.479A>G": 1, "c.10100A>G": 1}}	\N
5933803	5927084	c.11266C>G/c.13934G>A	{"RYR1": {"c.11266C>G": 1, "c.13934G>A": 1}}	\N
5933804	5927084	c.10100A>G/c.11518G>A	{"RYR1": {"c.10100A>G": 1, "c.11518G>A": 1}}	\N
5933805	5927084	c.7085A>G/c.10100A>G	{"RYR1": {"c.7085A>G": 1, "c.10100A>G": 1}}	\N
5933806	5927084	c.479A>G/c.4178A>G	{"RYR1": {"c.479A>G": 1, "c.4178A>G": 1}}	\N
5933807	5927084	c.652G>A/c.4178A>G	{"RYR1": {"c.652G>A": 1, "c.4178A>G": 1}}	\N
5933808	5927084	c.6178G>T/c.14693T>C	{"RYR1": {"c.6178G>T": 1, "c.14693T>C": 1}}	\N
5933809	5927084	c.1201C>G/c.5036G>A	{"RYR1": {"c.1201C>G": 1, "c.5036G>A": 1}}	\N
5933810	5927084	c.418G>A/c.14693T>C	{"RYR1": {"c.418G>A": 1, "c.14693T>C": 1}}	\N
5933811	5927084	c.10556C>T/c.12884C>T	{"RYR1": {"c.10556C>T": 1, "c.12884C>T": 1}}	\N
5933812	5927084	c.10616G>A/c.14680G>A	{"RYR1": {"c.10616G>A": 1, "c.14680G>A": 1}}	\N
5933813	5927084	c.6178G>T/c.6302T>A	{"RYR1": {"c.6178G>T": 1, "c.6302T>A": 1}}	\N
5933814	5927084	c.10100A>G/c.14639T>C	{"RYR1": {"c.10100A>G": 1, "c.14639T>C": 1}}	\N
5933815	5927084	c.7355G>C/c.11798A>G	{"RYR1": {"c.7355G>C": 1, "c.11798A>G": 1}}	\N
5933816	5927084	c.6388G>A/c.13513G>C	{"RYR1": {"c.6388G>A": 1, "c.13513G>C": 1}}	\N
5933817	5927084	c.6599C>T/c.8360C>G	{"RYR1": {"c.6599C>T": 1, "c.8360C>G": 1}}	\N
5933818	5927084	c.4024A>G/c.11813G>A	{"RYR1": {"c.4024A>G": 1, "c.11813G>A": 1}}	\N
5933819	5927084	c.4711A>G/c.14968A>G	{"RYR1": {"c.4711A>G": 1, "c.14968A>G": 1}}	\N
5933820	5927084	c.6599C>T/c.10747G>C	{"RYR1": {"c.6599C>T": 1, "c.10747G>C": 1}}	\N
5933821	5927084	c.7025A>G/c.9152G>A	{"RYR1": {"c.7025A>G": 1, "c.9152G>A": 1}}	\N
5933822	5927084	c.10237A>T/c.13513G>C	{"RYR1": {"c.10237A>T": 1, "c.13513G>C": 1}}	\N
5933823	5927084	c.479A>G/c.10747G>C	{"RYR1": {"c.479A>G": 1, "c.10747G>C": 1}}	\N
5933824	5927084	c.4711A>G/c.12533G>T	{"RYR1": {"c.4711A>G": 1, "c.12533G>T": 1}}	\N
5933825	5927084	c.2537C>T/c.4711A>G	{"RYR1": {"c.2537C>T": 1, "c.4711A>G": 1}}	\N
5933826	5927084	c.4178A>G/c.11958C>G	{"RYR1": {"c.4178A>G": 1, "c.11958C>G": 1}}	\N
5933827	5927084	c.5036G>A/c.11953T>C	{"RYR1": {"c.5036G>A": 1, "c.11953T>C": 1}}	\N
5933828	5927084	c.7355G>A/c.13513G>C	{"RYR1": {"c.7355G>A": 1, "c.13513G>C": 1}}	\N
5933829	5927084	c.6388G>A/c.11798A>G	{"RYR1": {"c.6388G>A": 1, "c.11798A>G": 1}}	\N
5933830	5927084	c.7879G>A/c.10747G>C	{"RYR1": {"c.7879G>A": 1, "c.10747G>C": 1}}	\N
5933831	5927084	c.9676G>C/c.10097G>A	{"RYR1": {"c.9676G>C": 1, "c.10097G>A": 1}}	\N
5933832	5927084	c.5317C>T/c.9848G>A	{"RYR1": {"c.5317C>T": 1, "c.9848G>A": 1}}	\N
5933833	5927084	c.5360C>T/c.11723A>T	{"RYR1": {"c.5360C>T": 1, "c.11723A>T": 1}}	\N
5933834	5927084	c.5186T>G/c.10097G>A	{"RYR1": {"c.5186T>G": 1, "c.10097G>A": 1}}	\N
5933835	5927084	c.7879G>A/c.8360C>G	{"RYR1": {"c.7879G>A": 1, "c.8360C>G": 1}}	\N
5933836	5927084	c.652G>A/c.10100A>G	{"RYR1": {"c.652G>A": 1, "c.10100A>G": 1}}	\N
5933837	5927084	c.10100A>G/c.10750G>C	{"RYR1": {"c.10100A>G": 1, "c.10750G>C": 1}}	\N
5933838	5927084	c.11798A>G/c.12121C>T	{"RYR1": {"c.11798A>G": 1, "c.12121C>T": 1}}	\N
5933839	5927084	c.7355G>C/c.13513G>C	{"RYR1": {"c.7355G>C": 1, "c.13513G>C": 1}}	\N
5933840	5927084	c.6961A>G/c.14186A>C	{"RYR1": {"c.6961A>G": 1, "c.14186A>C": 1}}	\N
5933841	5927084	c.7307G>A/c.11266C>G	{"RYR1": {"c.7307G>A": 1, "c.11266C>G": 1}}	\N
5933842	5927084	c.418G>A/c.6302T>A	{"RYR1": {"c.418G>A": 1, "c.6302T>A": 1}}	\N
5933843	5927084	c.7771C>G/c.10097G>A	{"RYR1": {"c.7771C>G": 1, "c.10097G>A": 1}}	\N
5933844	5927084	c.7097C>G/Reference	{"RYR1": {"Reference": 1, "c.7097C>G": 1}}	\N
5933845	5927084	c.12848A>T/c.14168G>A	{"RYR1": {"c.12848A>T": 1, "c.14168G>A": 1}}	\N
5933846	5927084	c.7355G>A/c.11798A>G	{"RYR1": {"c.7355G>A": 1, "c.11798A>G": 1}}	\N
5933847	5927084	c.4024A>G/c.14813T>C	{"RYR1": {"c.4024A>G": 1, "c.14813T>C": 1}}	\N
5933848	5927084	c.4024A>G/c.7199A>G	{"RYR1": {"c.4024A>G": 1, "c.7199A>G": 1}}	\N
5933849	5927084	c.3095G>A/c.10100A>G	{"RYR1": {"c.3095G>A": 1, "c.10100A>G": 1}}	\N
5933850	5927084	c.6640G>A/c.11266C>G	{"RYR1": {"c.6640G>A": 1, "c.11266C>G": 1}}	\N
5933851	5927084	c.4178A>G/c.14581C>T	{"RYR1": {"c.4178A>G": 1, "c.14581C>T": 1}}	\N
5933852	5927084	c.3095G>A/c.4178A>G	{"RYR1": {"c.3095G>A": 1, "c.4178A>G": 1}}	\N
5933853	5927084	c.5440A>G/c.6670C>T	{"RYR1": {"c.5440A>G": 1, "c.6670C>T": 1}}	\N
5933854	5927084	c.4178A>G/c.14678G>A	{"RYR1": {"c.4178A>G": 1, "c.14678G>A": 1}}	\N
5933855	5927084	c.7307G>A/c.7816T>A	{"RYR1": {"c.7307G>A": 1, "c.7816T>A": 1}}	\N
5933856	5927084	c.7032G>C/c.12881C>T	{"RYR1": {"c.7032G>C": 1, "c.12881C>T": 1}}	\N
5933857	5927084	c.4711A>G/c.8600T>A	{"RYR1": {"c.4711A>G": 1, "c.8600T>A": 1}}	\N
5933858	5927084	c.9797T>C/c.11266C>G	{"RYR1": {"c.9797T>C": 1, "c.11266C>G": 1}}	\N
5933859	5927084	c.2447C>T/c.10043G>A	{"RYR1": {"c.2447C>T": 1, "c.10043G>A": 1}}	\N
5933860	5927084	c.14422_14423delinsAA/Reference	{"RYR1": {"Reference": 1, "c.14422_14423delinsAA": 1}}	\N
5933861	5927084	c.992_994dup/c.7816T>A	{"RYR1": {"c.7816T>A": 1, "c.992_994dup": 1}}	\N
5933862	5927084	c.10616G>A/c.14051T>C	{"RYR1": {"c.10616G>A": 1, "c.14051T>C": 1}}	\N
5933863	5927084	c.4711A>G/c.14825G>T	{"RYR1": {"c.4711A>G": 1, "c.14825G>T": 1}}	\N
5933864	5927084	c.5360C>T/c.7787C>T	{"RYR1": {"c.5360C>T": 1, "c.7787C>T": 1}}	\N
5933865	5927084	c.625G>A/c.6670C>T	{"RYR1": {"c.625G>A": 1, "c.6670C>T": 1}}	\N
5933866	5927084	c.152C>A/c.12310G>C	{"RYR1": {"c.152C>A": 1, "c.12310G>C": 1}}	\N
5933867	5927084	c.4178A>G/c.6757C>T	{"RYR1": {"c.4178A>G": 1, "c.6757C>T": 1}}	\N
5933868	5927084	c.4024A>G/c.10042C>T	{"RYR1": {"c.4024A>G": 1, "c.10042C>T": 1}}	\N
5933869	5927084	c.6178G>T/c.8638G>A	{"RYR1": {"c.6178G>T": 1, "c.8638G>A": 1}}	\N
5933870	5927084	c.11798A>G/c.14197T>G	{"RYR1": {"c.11798A>G": 1, "c.14197T>G": 1}}	\N
5933871	5927084	c.9758T>C/c.10616G>A	{"RYR1": {"c.9758T>C": 1, "c.10616G>A": 1}}	\N
5933872	5927084	c.496G>A/c.11266C>G	{"RYR1": {"c.496G>A": 1, "c.11266C>G": 1}}	\N
5933873	5927084	c.4024A>G/c.7760A>G	{"RYR1": {"c.4024A>G": 1, "c.7760A>G": 1}}	\N
5933874	5927084	c.5341T>C/c.10097G>A	{"RYR1": {"c.5341T>C": 1, "c.10097G>A": 1}}	\N
5933875	5927084	c.6743G>A/c.7025A>G	{"RYR1": {"c.6743G>A": 1, "c.7025A>G": 1}}	\N
5933876	5927084	c.5441T>A/Reference	{"RYR1": {"Reference": 1, "c.5441T>A": 1}}	\N
5933877	5927084	c.5890C>T/c.7816T>A	{"RYR1": {"c.5890C>T": 1, "c.7816T>A": 1}}	\N
5933878	5927084	c.6670C>T/c.11723A>T	{"RYR1": {"c.6670C>T": 1, "c.11723A>T": 1}}	\N
5933879	5927084	c.9848G>A/c.10097G>A	{"RYR1": {"c.9848G>A": 1, "c.10097G>A": 1}}	\N
5933880	5927084	c.467G>A/c.12881C>T	{"RYR1": {"c.467G>A": 1, "c.12881C>T": 1}}	\N
5933881	5927084	c.7025A>G/c.9850T>A	{"RYR1": {"c.7025A>G": 1, "c.9850T>A": 1}}	\N
5933882	5927084	c.10747G>C/c.14524G>A	{"RYR1": {"c.10747G>C": 1, "c.14524G>A": 1}}	\N
5933883	5927084	c.2447C>T/c.7073T>A	{"RYR1": {"c.2447C>T": 1, "c.7073T>A": 1}}	\N
5933884	5927084	c.5360C>T/c.12848A>T	{"RYR1": {"c.5360C>T": 1, "c.12848A>T": 1}}	\N
5933885	5927084	c.9152G>A/c.12310G>C	{"RYR1": {"c.9152G>A": 1, "c.12310G>C": 1}}	\N
5933886	5927084	c.6670C>T/c.7317G>C	{"RYR1": {"c.6670C>T": 1, "c.7317G>C": 1}}	\N
5933887	5927084	c.497A>G/c.2447C>T	{"RYR1": {"c.497A>G": 1, "c.2447C>T": 1}}	\N
5933888	5927084	c.8527T>C/c.14168G>A	{"RYR1": {"c.8527T>C": 1, "c.14168G>A": 1}}	\N
5933889	5927084	c.5317C>T/c.7097C>G	{"RYR1": {"c.5317C>T": 1, "c.7097C>G": 1}}	\N
5933890	5927084	c.418G>A/c.8638G>A	{"RYR1": {"c.418G>A": 1, "c.8638G>A": 1}}	\N
5933891	5927084	c.8360C>G/c.11953T>C	{"RYR1": {"c.8360C>G": 1, "c.11953T>C": 1}}	\N
5933892	5927084	c.7025A>G/c.13702C>G	{"RYR1": {"c.7025A>G": 1, "c.13702C>G": 1}}	\N
5933893	5927084	c.3418C>T/c.7816T>A	{"RYR1": {"c.3418C>T": 1, "c.7816T>A": 1}}	\N
5933894	5927084	c.6847A>C/Reference	{"RYR1": {"Reference": 1, "c.6847A>C": 1}}	\N
5933895	5927084	c.178G>T/c.6961A>G	{"RYR1": {"c.178G>T": 1, "c.6961A>G": 1}}	\N
5933896	5927084	c.1201C>A/c.5036G>A	{"RYR1": {"c.1201C>A": 1, "c.5036G>A": 1}}	\N
5933897	5927084	c.4024A>G/c.7032G>C	{"RYR1": {"c.4024A>G": 1, "c.7032G>C": 1}}	\N
5933898	5927084	c.7816T>A/c.12115A>T	{"RYR1": {"c.7816T>A": 1, "c.12115A>T": 1}}	\N
5933899	5927084	c.10747G>C/c.14364+1G>T	{"RYR1": {"c.10747G>C": 1, "c.14364+1G>T": 1}}	\N
5933900	5927084	c.1100G>T/c.11266C>G	{"RYR1": {"c.1100G>T": 1, "c.11266C>G": 1}}	\N
5933901	5927084	c.946C>T/c.2447C>T	{"RYR1": {"c.946C>T": 1, "c.2447C>T": 1}}	\N
5933902	5927084	c.8005G>A/c.13513G>C	{"RYR1": {"c.8005G>A": 1, "c.13513G>C": 1}}	\N
5933903	5927084	c.8600T>A/c.12406C>A	{"RYR1": {"c.8600T>A": 1, "c.12406C>A": 1}}	\N
5933904	5927084	c.12310G>C/c.12398A>G	{"RYR1": {"c.12310G>C": 1, "c.12398A>G": 1}}	\N
5897762	5897389	*68/*130	{"CYP2D6": {"*68": 1, "*130": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
5897763	5897389	*4x2/*154	{"CYP2D6": {"*154": 1, "*4x2": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": 0.000020394324, "African American/Afro-Caribbean": null}
5897764	5897389	*38/*146x2	{"CYP2D6": {"*38": 1, "*146x2": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
5897765	5897389	*4x2/*153	{"CYP2D6": {"*153": 1, "*4x2": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": 0.000020394324, "African American/Afro-Caribbean": null}
5897766	5897389	*69/*108	{"CYP2D6": {"*69": 1, "*108": 1}}	{"Latino": null, "American": 0.0, "European": 0.0000060, "Oceanian": null, "East Asian": 0.0, "Near Eastern": null, "Central/South Asian": 0.0, "Sub-Saharan African": 0.0, "African American/Afro-Caribbean": 0.0}
5897767	5897389	*68/*118	{"CYP2D6": {"*68": 1, "*118": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
5897768	5897389	*69/*107	{"CYP2D6": {"*69": 1, "*107": 1}}	{"Latino": null, "American": null, "European": null, "Oceanian": null, "East Asian": null, "Near Eastern": null, "Central/South Asian": null, "Sub-Saharan African": null, "African American/Afro-Caribbean": null}
5933906	5933905	c.178G>T/c.11813G>A	{"RYR1": {"c.178G>T": 1, "c.11813G>A": 1}}	\N
5933907	5933905	c.15059G>C/c.15059G>C	{"RYR1": {"c.15059G>C": 2}}	\N
5933908	5933905	c.212C>A/c.13913G>A	{"RYR1": {"c.212C>A": 1, "c.13913G>A": 1}}	\N
5933909	5933905	c.947G>T/c.7787C>T	{"RYR1": {"c.947G>T": 1, "c.7787C>T": 1}}	\N
5933910	5933905	c.9848G>A/c.11748T>G	{"RYR1": {"c.9848G>A": 1, "c.11748T>G": 1}}	\N
5933911	5933905	c.625G>A/c.14422_14423delinsAA	{"RYR1": {"c.625G>A": 1, "c.14422_14423delinsAA": 1}}	\N
5933912	5933905	c.7099G>A/c.14818G>A	{"RYR1": {"c.7099G>A": 1, "c.14818G>A": 1}}	\N
5933913	5933905	c.12242C>T/c.13934G>A	{"RYR1": {"c.12242C>T": 1, "c.13934G>A": 1}}	\N
5933914	5933905	c.9797T>C/c.13672C>T	{"RYR1": {"c.9797T>C": 1, "c.13672C>T": 1}}	\N
5933915	5933905	c.6757C>T/c.11132C>T	{"RYR1": {"c.6757C>T": 1, "c.11132C>T": 1}}	\N
5933916	5933905	c.7787C>T/c.11416G>A	{"RYR1": {"c.7787C>T": 1, "c.11416G>A": 1}}	\N
5933917	5933905	c.488G>A/c.14126C>T	{"RYR1": {"c.488G>A": 1, "c.14126C>T": 1}}	\N
5933918	5933905	c.992_994dup/c.7099G>A	{"RYR1": {"c.7099G>A": 1, "c.992_994dup": 1}}	\N
5933919	5933905	c.6599C>T/c.9797T>C	{"RYR1": {"c.6599C>T": 1, "c.9797T>C": 1}}	\N
5933920	5933905	c.455C>A/c.8290G>A	{"RYR1": {"c.455C>A": 1, "c.8290G>A": 1}}	\N
5933921	5933905	c.1144C>A/c.9649T>C	{"RYR1": {"c.1144C>A": 1, "c.9649T>C": 1}}	\N
5933922	5933905	c.625G>A/c.12413T>C	{"RYR1": {"c.625G>A": 1, "c.12413T>C": 1}}	\N
5933923	5933905	c.1024G>A/c.10891G>T	{"RYR1": {"c.1024G>A": 1, "c.10891G>T": 1}}	\N
5933924	5933905	c.946C>T/c.5024T>C	{"RYR1": {"c.946C>T": 1, "c.5024T>C": 1}}	\N
5933925	5933905	c.8005G>A/c.11813G>A	{"RYR1": {"c.8005G>A": 1, "c.11813G>A": 1}}	\N
5933926	5933905	c.4775C>T/c.4775C>T	{"RYR1": {"c.4775C>T": 2}}	\N
5933927	5933905	c.7018T>C/c.12398A>G	{"RYR1": {"c.7018T>C": 1, "c.12398A>G": 1}}	\N
5933928	5933905	c.680A>T/c.14639T>C	{"RYR1": {"c.680A>T": 1, "c.14639T>C": 1}}	\N
5933929	5933905	c.11813G>A/c.14813T>C	{"RYR1": {"c.11813G>A": 1, "c.14813T>C": 1}}	\N
5933930	5933905	c.51_53del/c.13760C>T	{"RYR1": {"c.13760C>T": 1, "c.51_53del": 1}}	\N
5933931	5933905	c.7199A>G/c.14471T>C	{"RYR1": {"c.7199A>G": 1, "c.14471T>C": 1}}	\N
5933932	5933905	c.10237A>T/c.14458G>T	{"RYR1": {"c.10237A>T": 1, "c.14458G>T": 1}}	\N
5933933	5933905	c.14509C>G/c.14558C>T	{"RYR1": {"c.14509C>G": 1, "c.14558C>T": 1}}	\N
5933934	5933905	c.3418C>T/c.9499C>T	{"RYR1": {"c.3418C>T": 1, "c.9499C>T": 1}}	\N
5933935	5933905	c.1100G>A/c.14693T>C	{"RYR1": {"c.1100G>A": 1, "c.14693T>C": 1}}	\N
5933936	5933905	c.7777C>G/c.11120G>T	{"RYR1": {"c.7777C>G": 1, "c.11120G>T": 1}}	\N
5933937	5933905	c.13760C>T/c.14558C>T	{"RYR1": {"c.13760C>T": 1, "c.14558C>T": 1}}	\N
5933938	5933905	c.1475G>A/c.7522C>G	{"RYR1": {"c.1475G>A": 1, "c.7522C>G": 1}}	\N
5933939	5933905	c.6743G>A/c.12533G>T	{"RYR1": {"c.6743G>A": 1, "c.12533G>T": 1}}	\N
5933940	5933905	c.1422G>T/c.11947C>T	{"RYR1": {"c.1422G>T": 1, "c.11947C>T": 1}}	\N
5933941	5933905	c.190T>C/c.8638G>A	{"RYR1": {"c.190T>C": 1, "c.8638G>A": 1}}	\N
5933942	5933905	c.8600T>A/c.11748T>G	{"RYR1": {"c.8600T>A": 1, "c.11748T>G": 1}}	\N
5933943	5933905	c.8638G>A/c.14968A>G	{"RYR1": {"c.8638G>A": 1, "c.14968A>G": 1}}	\N
5933944	5933905	c.7355G>C/c.14639T>C	{"RYR1": {"c.7355G>C": 1, "c.14639T>C": 1}}	\N
5933945	5933905	c.493G>A/c.3656A>C	{"RYR1": {"c.493G>A": 1, "c.3656A>C": 1}}	\N
5933946	5933905	c.7522C>G/c.14968A>G	{"RYR1": {"c.7522C>G": 1, "c.14968A>G": 1}}	\N
5933947	5933905	c.992_994dup/c.9268G>A	{"RYR1": {"c.9268G>A": 1, "c.992_994dup": 1}}	\N
5933948	5933905	c.5440A>G/c.7075C>T	{"RYR1": {"c.5440A>G": 1, "c.7075C>T": 1}}	\N
5933949	5933905	c.7097C>G/c.7199A>G	{"RYR1": {"c.7097C>G": 1, "c.7199A>G": 1}}	\N
5933950	5933905	c.1475G>A/c.12383C>T	{"RYR1": {"c.1475G>A": 1, "c.12383C>T": 1}}	\N
5933951	5933905	c.1598G>A/c.7112A>G	{"RYR1": {"c.1598G>A": 1, "c.7112A>G": 1}}	\N
5933952	5933905	c.2996G>A/c.13760C>T	{"RYR1": {"c.2996G>A": 1, "c.13760C>T": 1}}	\N
5933953	5933905	c.13702C>G/c.14639T>C	{"RYR1": {"c.13702C>G": 1, "c.14639T>C": 1}}	\N
5933954	5933905	c.528G>T/c.7018T>C	{"RYR1": {"c.528G>T": 1, "c.7018T>C": 1}}	\N
5933955	5933905	c.5033A>G/c.10229C>A	{"RYR1": {"c.5033A>G": 1, "c.10229C>A": 1}}	\N
5933956	5933905	c.1834G>C/c.13505A>G	{"RYR1": {"c.1834G>C": 1, "c.13505A>G": 1}}	\N
5933957	5933905	c.3418C>T/c.7089C>G	{"RYR1": {"c.3418C>T": 1, "c.7089C>G": 1}}	\N
5933958	5933905	c.8290G>A/c.11120G>T	{"RYR1": {"c.8290G>A": 1, "c.11120G>T": 1}}	\N
5933959	5933905	c.1201C>A/c.11126C>T	{"RYR1": {"c.1201C>A": 1, "c.11126C>T": 1}}	\N
5933960	5933905	c.9758T>C/c.14680G>A	{"RYR1": {"c.9758T>C": 1, "c.14680G>A": 1}}	\N
5933961	5933905	c.6640G>A/c.13994_13995delTCinsCT	{"RYR1": {"c.6640G>A": 1, "c.13994_13995delTCinsCT": 1}}	\N
5933962	5933905	c.4747C>T/c.14680G>A	{"RYR1": {"c.4747C>T": 1, "c.14680G>A": 1}}	\N
5933963	5933905	c.51_53del/c.6742C>T	{"RYR1": {"c.6742C>T": 1, "c.51_53del": 1}}	\N
5933964	5933905	c.5341T>C/c.7778G>A	{"RYR1": {"c.5341T>C": 1, "c.7778G>A": 1}}	\N
5933965	5933905	c.1422G>T/c.12553G>A	{"RYR1": {"c.1422G>T": 1, "c.12553G>A": 1}}	\N
5933966	5933905	c.5033A>G/c.11314C>T	{"RYR1": {"c.5033A>G": 1, "c.11314C>T": 1}}	\N
5933967	5933905	c.152C>A/c.14968A>G	{"RYR1": {"c.152C>A": 1, "c.14968A>G": 1}}	\N
5933968	5933905	c.8527T>C/c.14524G>A	{"RYR1": {"c.8527T>C": 1, "c.14524G>A": 1}}	\N
5933969	5933905	c.14197T>G/c.14558C>T	{"RYR1": {"c.14197T>G": 1, "c.14558C>T": 1}}	\N
5933970	5933905	c.251C>T/c.14186A>C	{"RYR1": {"c.251C>T": 1, "c.14186A>C": 1}}	\N
5933971	5933905	c.7089C>G/c.7292A>T	{"RYR1": {"c.7089C>G": 1, "c.7292A>T": 1}}	\N
5933972	5933905	c.7778G>A/c.9499C>T	{"RYR1": {"c.7778G>A": 1, "c.9499C>T": 1}}	\N
5933973	5933905	c.7112A>G/c.12689T>G	{"RYR1": {"c.7112A>G": 1, "c.12689T>G": 1}}	\N
5933974	5933905	c.3656A>C/c.14558C>T	{"RYR1": {"c.3656A>C": 1, "c.14558C>T": 1}}	\N
5933975	5933905	c.7777C>G/c.10237A>T	{"RYR1": {"c.7777C>G": 1, "c.10237A>T": 1}}	\N
5933976	5933905	c.7787C>T/c.14051T>C	{"RYR1": {"c.7787C>T": 1, "c.14051T>C": 1}}	\N
5933977	5933905	c.6742C>T/c.7771C>G	{"RYR1": {"c.6742C>T": 1, "c.7771C>G": 1}}	\N
5933978	5933905	c.5132A>G/c.14813T>C	{"RYR1": {"c.5132A>G": 1, "c.14813T>C": 1}}	\N
5933979	5933905	c.8054C>T/c.14424C>A	{"RYR1": {"c.8054C>T": 1, "c.14424C>A": 1}}	\N
5933980	5933905	c.680A>T/c.6377G>A	{"RYR1": {"c.680A>T": 1, "c.6377G>A": 1}}	\N
5933981	5933905	c.10237A>T/c.14458G>A	{"RYR1": {"c.10237A>T": 1, "c.14458G>A": 1}}	\N
5933982	5933905	c.2996G>A/c.12398A>G	{"RYR1": {"c.2996G>A": 1, "c.12398A>G": 1}}	\N
5933983	5933905	c.1209C>G/c.6671G>A	{"RYR1": {"c.1209C>G": 1, "c.6671G>A": 1}}	\N
5933984	5933905	c.3667G>A/c.15059G>C	{"RYR1": {"c.3667G>A": 1, "c.15059G>C": 1}}	\N
5933985	5933905	c.15059G>C/c.15060G>C	{"RYR1": {"c.15059G>C": 1, "c.15060G>C": 1}}	\N
5933986	5933905	c.7097C>G/c.14818G>A	{"RYR1": {"c.7097C>G": 1, "c.14818G>A": 1}}	\N
5933987	5933905	c.1598G>A/c.9356G>A	{"RYR1": {"c.1598G>A": 1, "c.9356G>A": 1}}	\N
5933988	5933905	c.680A>T/c.1144C>A	{"RYR1": {"c.680A>T": 1, "c.1144C>A": 1}}	\N
5933989	5933905	c.3667G>A/c.15060G>C	{"RYR1": {"c.3667G>A": 1, "c.15060G>C": 1}}	\N
5933990	5933905	c.2996G>A/c.6742C>T	{"RYR1": {"c.2996G>A": 1, "c.6742C>T": 1}}	\N
5933991	5933905	c.5132A>G/c.5440A>G	{"RYR1": {"c.5132A>G": 1, "c.5440A>G": 1}}	\N
5933992	5933905	c.1201C>A/c.10042C>T	{"RYR1": {"c.1201C>A": 1, "c.10042C>T": 1}}	\N
5933993	5933905	c.9649T>C/c.9848G>A	{"RYR1": {"c.9649T>C": 1, "c.9848G>A": 1}}	\N
5933994	5933905	c.526G>A/c.11086G>C	{"RYR1": {"c.526G>A": 1, "c.11086G>C": 1}}	\N
5933995	5933905	c.947G>T/c.8188G>C	{"RYR1": {"c.947G>T": 1, "c.8188G>C": 1}}	\N
5933996	5933905	c.11953T>C/c.14814C>G	{"RYR1": {"c.11953T>C": 1, "c.14814C>G": 1}}	\N
5933997	5933905	c.1422G>T/c.7073T>A	{"RYR1": {"c.1422G>T": 1, "c.7073T>A": 1}}	\N
5933998	5933905	c.1553T>C/c.4763C>T	{"RYR1": {"c.1553T>C": 1, "c.4763C>T": 1}}	\N
5933999	5933905	c.190T>C/c.479A>G	{"RYR1": {"c.190T>C": 1, "c.479A>G": 1}}	\N
5934000	5933905	c.526G>A/c.6478G>A	{"RYR1": {"c.526G>A": 1, "c.6478G>A": 1}}	\N
5934001	5933905	c.6377G>A/c.12689T>G	{"RYR1": {"c.6377G>A": 1, "c.12689T>G": 1}}	\N
5934002	5933905	c.7075C>T/c.14424C>A	{"RYR1": {"c.7075C>T": 1, "c.14424C>A": 1}}	\N
5934003	5933905	c.7771C>G/c.11748T>G	{"RYR1": {"c.7771C>G": 1, "c.11748T>G": 1}}	\N
5934004	5933905	c.7771C>T/c.11953T>C	{"RYR1": {"c.7771C>T": 1, "c.11953T>C": 1}}	\N
5934005	5933905	c.6742C>T/c.9850T>A	{"RYR1": {"c.6742C>T": 1, "c.9850T>A": 1}}	\N
5934006	5933905	c.10750G>C/c.15059G>C	{"RYR1": {"c.10750G>C": 1, "c.15059G>C": 1}}	\N
5934007	5933905	c.947G>T/c.9649T>C	{"RYR1": {"c.947G>T": 1, "c.9649T>C": 1}}	\N
5934008	5933905	c.3095G>A/c.11132C>T	{"RYR1": {"c.3095G>A": 1, "c.11132C>T": 1}}	\N
5934009	5933905	c.2537C>T/c.14524G>A	{"RYR1": {"c.2537C>T": 1, "c.14524G>A": 1}}	\N
5934010	5933905	c.652G>A/c.2924G>A	{"RYR1": {"c.652G>A": 1, "c.2924G>A": 1}}	\N
5934011	5933905	c.528G>T/c.7085A>G	{"RYR1": {"c.528G>T": 1, "c.7085A>G": 1}}	\N
5934012	5933905	c.9499C>T/c.11126C>T	{"RYR1": {"c.9499C>T": 1, "c.11126C>T": 1}}	\N
5934013	5933905	c.5341T>C/c.14782A>G	{"RYR1": {"c.5341T>C": 1, "c.14782A>G": 1}}	\N
5934014	5933905	c.680A>T/c.5441T>A	{"RYR1": {"c.680A>T": 1, "c.5441T>A": 1}}	\N
5934015	5933905	c.7073T>A/c.11723A>T	{"RYR1": {"c.7073T>A": 1, "c.11723A>T": 1}}	\N
5934016	5933905	c.455C>A/c.6599C>T	{"RYR1": {"c.455C>A": 1, "c.6599C>T": 1}}	\N
5934017	5933905	c.641C>T/c.14458G>A	{"RYR1": {"c.641C>T": 1, "c.14458G>A": 1}}	\N
5934018	5933905	c.1459C>G/c.14201G>A	{"RYR1": {"c.1459C>G": 1, "c.14201G>A": 1}}	\N
5934019	5933905	c.11953T>C/c.12115A>T	{"RYR1": {"c.11953T>C": 1, "c.12115A>T": 1}}	\N
5934020	5933905	c.467G>A/c.2654G>A	{"RYR1": {"c.467G>A": 1, "c.2654G>A": 1}}	\N
5934021	5933905	c.251C>T/c.6757C>T	{"RYR1": {"c.251C>T": 1, "c.6757C>T": 1}}	\N
5934022	5933905	c.7089C>G/c.8198G>A	{"RYR1": {"c.7089C>G": 1, "c.8198G>A": 1}}	\N
5934023	5933905	c.11748T>G/c.11748T>G	{"RYR1": {"c.11748T>G": 2}}	\N
5934024	5933905	c.8527T>C/c.13702C>G	{"RYR1": {"c.8527T>C": 1, "c.13702C>G": 1}}	\N
5934025	5933905	c.5132A>G/c.10252A>G	{"RYR1": {"c.5132A>G": 1, "c.10252A>G": 1}}	\N
5934026	5933905	c.8188G>C/c.12848A>T	{"RYR1": {"c.8188G>C": 1, "c.12848A>T": 1}}	\N
5934027	5933905	c.1598G>A/c.14364+1G>T	{"RYR1": {"c.1598G>A": 1, "c.14364+1G>T": 1}}	\N
5934028	5933905	c.9797T>C/c.12689T>G	{"RYR1": {"c.9797T>C": 1, "c.12689T>G": 1}}	\N
5934029	5933905	c.1460T>C/c.8729C>T	{"RYR1": {"c.1460T>C": 1, "c.8729C>T": 1}}	\N
5934030	5933905	c.947G>T/c.7522C>G	{"RYR1": {"c.947G>T": 1, "c.7522C>G": 1}}	\N
5934031	5933905	c.2122G>A/c.12533G>T	{"RYR1": {"c.2122G>A": 1, "c.12533G>T": 1}}	\N
5934032	5933905	c.13990T>C/c.14818G>A	{"RYR1": {"c.13990T>C": 1, "c.14818G>A": 1}}	\N
5934033	5933905	c.6757C>T/c.8729C>T	{"RYR1": {"c.6757C>T": 1, "c.8729C>T": 1}}	\N
5934034	5933905	c.14197T>G/c.14509C>G	{"RYR1": {"c.14197T>G": 1, "c.14509C>G": 1}}	\N
5934035	5933905	c.9635A>G/c.11086G>C	{"RYR1": {"c.9635A>G": 1, "c.11086G>C": 1}}	\N
5934036	5933905	c.5890C>T/c.14693T>C	{"RYR1": {"c.5890C>T": 1, "c.14693T>C": 1}}	\N
5934037	5933905	c.6478G>A/c.6478G>A	{"RYR1": {"c.6478G>A": 2}}	\N
5934038	5933905	c.1201C>G/c.10042C>T	{"RYR1": {"c.1201C>G": 1, "c.10042C>T": 1}}	\N
5934039	5933905	c.1453A>G/c.5441T>A	{"RYR1": {"c.1453A>G": 1, "c.5441T>A": 1}}	\N
5934040	5933905	c.652G>A/c.14186A>C	{"RYR1": {"c.652G>A": 1, "c.14186A>C": 1}}	\N
5934041	5933905	c.152C>A/c.652G>A	{"RYR1": {"c.152C>A": 1, "c.652G>A": 1}}	\N
5934042	5933905	c.1201C>G/c.7760A>G	{"RYR1": {"c.1201C>G": 1, "c.7760A>G": 1}}	\N
5934043	5933905	c.5341T>C/c.6847A>C	{"RYR1": {"c.5341T>C": 1, "c.6847A>C": 1}}	\N
5934044	5933905	c.6478G>A/c.6671G>A	{"RYR1": {"c.6478G>A": 1, "c.6671G>A": 1}}	\N
5934045	5933905	c.14524G>A/c.14524G>A	{"RYR1": {"c.14524G>A": 2}}	\N
5934046	5933905	c.1453A>G/c.6377G>A	{"RYR1": {"c.1453A>G": 1, "c.6377G>A": 1}}	\N
5934047	5933905	c.6377G>A/c.13672C>T	{"RYR1": {"c.6377G>A": 1, "c.13672C>T": 1}}	\N
5934048	5933905	c.2996G>A/c.14387A>G	{"RYR1": {"c.2996G>A": 1, "c.14387A>G": 1}}	\N
5934049	5933905	c.641C>T/c.14458G>T	{"RYR1": {"c.641C>T": 1, "c.14458G>T": 1}}	\N
5934050	5933905	c.946C>T/c.14693T>C	{"RYR1": {"c.946C>T": 1, "c.14693T>C": 1}}	\N
5934051	5933905	c.3095G>A/c.11086G>C	{"RYR1": {"c.3095G>A": 1, "c.11086G>C": 1}}	\N
5934052	5933905	c.3166G>A/c.3166G>A	{"RYR1": {"c.3166G>A": 2}}	\N
5934053	5933905	c.11314C>T/c.13702C>G	{"RYR1": {"c.11314C>T": 1, "c.13702C>G": 1}}	\N
5934054	5933905	c.4775C>T/c.14817C>A	{"RYR1": {"c.4775C>T": 1, "c.14817C>A": 1}}	\N
5934055	5933905	c.10750G>C/c.15060G>C	{"RYR1": {"c.10750G>C": 1, "c.15060G>C": 1}}	\N
5934056	5933905	c.51_53del/c.12398A>G	{"RYR1": {"c.12398A>G": 1, "c.51_53del": 1}}	\N
5934057	5933905	c.625G>A/c.6548G>A	{"RYR1": {"c.625G>A": 1, "c.6548G>A": 1}}	\N
5934058	5933905	c.10237A>T/c.12413T>C	{"RYR1": {"c.10237A>T": 1, "c.12413T>C": 1}}	\N
5934059	5933905	c.1144C>A/c.8188G>C	{"RYR1": {"c.1144C>A": 1, "c.8188G>C": 1}}	\N
5934060	5933905	c.212C>A/c.9758T>C	{"RYR1": {"c.212C>A": 1, "c.9758T>C": 1}}	\N
5934061	5933905	c.1024G>A/c.1475G>A	{"RYR1": {"c.1024G>A": 1, "c.1475G>A": 1}}	\N
5934062	5933905	c.3527C>T/c.12028G>A	{"RYR1": {"c.3527C>T": 1, "c.12028G>A": 1}}	\N
5934063	5933905	c.496G>A/c.14197T>G	{"RYR1": {"c.496G>A": 1, "c.14197T>G": 1}}	\N
5934064	5933905	c.4747C>T/c.12028G>A	{"RYR1": {"c.4747C>T": 1, "c.12028G>A": 1}}	\N
5934065	5933905	c.7385C>T/c.11086G>C	{"RYR1": {"c.7385C>T": 1, "c.11086G>C": 1}}	\N
5934066	5933905	c.1553T>C/c.4775C>T	{"RYR1": {"c.1553T>C": 1, "c.4775C>T": 1}}	\N
5934067	5933905	c.497A>G/c.8518C>T	{"RYR1": {"c.497A>G": 1, "c.8518C>T": 1}}	\N
5934068	5933905	c.6548G>A/c.8189A>G	{"RYR1": {"c.6548G>A": 1, "c.8189A>G": 1}}	\N
5934069	5933905	c.2050G>C/c.7307G>A	{"RYR1": {"c.2050G>C": 1, "c.7307G>A": 1}}	\N
5934070	5933905	c.479A>G/c.5132A>G	{"RYR1": {"c.479A>G": 1, "c.5132A>G": 1}}	\N
5934071	5933905	c.3656A>C/c.9652G>A	{"RYR1": {"c.3656A>C": 1, "c.9652G>A": 1}}	\N
5934072	5933905	c.13672C>T/c.14558C>T	{"RYR1": {"c.13672C>T": 1, "c.14558C>T": 1}}	\N
5934073	5933905	c.4763C>T/c.7032G>C	{"RYR1": {"c.4763C>T": 1, "c.7032G>C": 1}}	\N
5934074	5933905	c.9758T>C/c.12028G>A	{"RYR1": {"c.9758T>C": 1, "c.12028G>A": 1}}	\N
5934075	5933905	c.14458G>A/c.14582G>A	{"RYR1": {"c.14458G>A": 1, "c.14582G>A": 1}}	\N
5934076	5933905	c.1834G>C/c.6743G>A	{"RYR1": {"c.1834G>C": 1, "c.6743G>A": 1}}	\N
5934077	5933905	c.12121C>T/c.14693T>C	{"RYR1": {"c.12121C>T": 1, "c.14693T>C": 1}}	\N
5934078	5933905	c.10556C>T/c.11086G>C	{"RYR1": {"c.10556C>T": 1, "c.11086G>C": 1}}	\N
5934079	5933905	c.1453A>G/c.14639T>C	{"RYR1": {"c.1453A>G": 1, "c.14639T>C": 1}}	\N
5934080	5933905	c.12064A>G/c.14449A>T	{"RYR1": {"c.12064A>G": 1, "c.14449A>T": 1}}	\N
5934081	5933905	c.6671G>A/c.7307G>A	{"RYR1": {"c.6671G>A": 1, "c.7307G>A": 1}}	\N
5934082	5933905	c.178G>T/c.7292A>T	{"RYR1": {"c.178G>T": 1, "c.7292A>T": 1}}	\N
5934083	5933905	c.12115A>T/c.14424C>A	{"RYR1": {"c.12115A>T": 1, "c.14424C>A": 1}}	\N
5934084	5933905	c.1460T>C/c.10891G>T	{"RYR1": {"c.1460T>C": 1, "c.10891G>T": 1}}	\N
5934085	5933905	c.488G>A/c.7771C>T	{"RYR1": {"c.488G>A": 1, "c.7771C>T": 1}}	\N
5934086	5933905	c.992_994dup/c.7771C>T	{"RYR1": {"c.7771C>T": 1, "c.992_994dup": 1}}	\N
5934087	5933905	c.1411C>T/c.1453A>G	{"RYR1": {"c.1411C>T": 1, "c.1453A>G": 1}}	\N
5934088	5933905	c.5440A>G/c.10043G>A	{"RYR1": {"c.5440A>G": 1, "c.10043G>A": 1}}	\N
5934089	5933905	c.6847A>C/c.13934G>A	{"RYR1": {"c.6847A>C": 1, "c.13934G>A": 1}}	\N
5934090	5933905	c.680A>T/c.11813G>A	{"RYR1": {"c.680A>T": 1, "c.11813G>A": 1}}	\N
5934091	5933905	c.9499C>T/c.12355A>T	{"RYR1": {"c.9499C>T": 1, "c.12355A>T": 1}}	\N
5934092	5933905	c.677T>A/c.8518C>T	{"RYR1": {"c.677T>A": 1, "c.8518C>T": 1}}	\N
5934093	5933905	c.10891G>T/c.13994_13995delTCinsCT	{"RYR1": {"c.10891G>T": 1, "c.13994_13995delTCinsCT": 1}}	\N
5934094	5933905	c.488G>A/c.7771C>G	{"RYR1": {"c.488G>A": 1, "c.7771C>G": 1}}	\N
5934095	5933905	c.992_994dup/c.14126C>T	{"RYR1": {"c.14126C>T": 1, "c.992_994dup": 1}}	\N
5934096	5933905	c.7032G>C/c.10042C>T	{"RYR1": {"c.7032G>C": 1, "c.10042C>T": 1}}	\N
5934097	5933905	c.10237A>T/c.14422_14423delinsAA	{"RYR1": {"c.10237A>T": 1, "c.14422_14423delinsAA": 1}}	\N
5934098	5933905	c.1453A>G/c.11813G>A	{"RYR1": {"c.1453A>G": 1, "c.11813G>A": 1}}	\N
5934099	5933905	c.7317G>C/c.12028G>A	{"RYR1": {"c.7317G>C": 1, "c.12028G>A": 1}}	\N
5934100	5933905	c.1553T>C/c.1834G>C	{"RYR1": {"c.1553T>C": 1, "c.1834G>C": 1}}	\N
5934101	5933905	c.2537C>T/c.7085A>G	{"RYR1": {"c.2537C>T": 1, "c.7085A>G": 1}}	\N
5934102	5933905	c.6710G>A/c.12848A>T	{"RYR1": {"c.6710G>A": 1, "c.12848A>T": 1}}	\N
5934103	5933905	c.992_994dup/c.7771C>G	{"RYR1": {"c.7771C>G": 1, "c.992_994dup": 1}}	\N
5934104	5933905	c.1209C>G/c.6478G>A	{"RYR1": {"c.1209C>G": 1, "c.6478G>A": 1}}	\N
5934105	5933905	c.51_53del/c.14582G>A	{"RYR1": {"c.14582G>A": 1, "c.51_53del": 1}}	\N
5934106	5933905	c.467G>A/c.1100G>T	{"RYR1": {"c.467G>A": 1, "c.1100G>T": 1}}	\N
5934107	5933905	c.212C>A/c.7487C>T	{"RYR1": {"c.212C>A": 1, "c.7487C>T": 1}}	\N
5934108	5933905	c.3127C>T/c.5440A>G	{"RYR1": {"c.3127C>T": 1, "c.5440A>G": 1}}	\N
5934109	5933905	c.178G>T/c.8198G>A	{"RYR1": {"c.178G>T": 1, "c.8198G>A": 1}}	\N
5934110	5933905	c.1460T>C/c.11132C>T	{"RYR1": {"c.1460T>C": 1, "c.11132C>T": 1}}	\N
5934111	5933905	c.11132C>T/c.11723A>T	{"RYR1": {"c.11132C>T": 1, "c.11723A>T": 1}}	\N
5934112	5933905	c.7210G>A/c.14817C>A	{"RYR1": {"c.7210G>A": 1, "c.14817C>A": 1}}	\N
5934113	5933905	c.1598G>A/c.7355G>A	{"RYR1": {"c.1598G>A": 1, "c.7355G>A": 1}}	\N
5934114	5933905	c.1598G>A/c.7355G>C	{"RYR1": {"c.1598G>A": 1, "c.7355G>C": 1}}	\N
5934115	5933905	c.1411C>T/c.5186T>G	{"RYR1": {"c.1411C>T": 1, "c.5186T>G": 1}}	\N
5934116	5933905	c.1597C>A/c.7199A>G	{"RYR1": {"c.1597C>A": 1, "c.7199A>G": 1}}	\N
5934117	5933905	c.6388G>A/c.12115A>T	{"RYR1": {"c.6388G>A": 1, "c.12115A>T": 1}}	\N
5934118	5933905	c.526G>A/c.6671G>A	{"RYR1": {"c.526G>A": 1, "c.6671G>A": 1}}	\N
5934119	5933905	c.13760C>T/c.14509C>G	{"RYR1": {"c.13760C>T": 1, "c.14509C>G": 1}}	\N
5934120	5933905	c.1201C>G/c.6037A>C	{"RYR1": {"c.1201C>G": 1, "c.6037A>C": 1}}	\N
5934121	5933905	c.6388G>A/c.15060G>C	{"RYR1": {"c.6388G>A": 1, "c.15060G>C": 1}}	\N
5934122	5933905	c.6635T>A/c.8654C>G	{"RYR1": {"c.6635T>A": 1, "c.8654C>G": 1}}	\N
5934123	5933905	c.467G>A/c.1100G>A	{"RYR1": {"c.467G>A": 1, "c.1100G>A": 1}}	\N
5934124	5933905	c.3127C>T/c.14567C>G	{"RYR1": {"c.3127C>T": 1, "c.14567C>G": 1}}	\N
5934125	5933905	c.178G>A/c.2050G>C	{"RYR1": {"c.178G>A": 1, "c.2050G>C": 1}}	\N
5934126	5933905	c.11813G>A/c.13505A>G	{"RYR1": {"c.11813G>A": 1, "c.13505A>G": 1}}	\N
5934127	5933905	c.497A>G/c.14825G>T	{"RYR1": {"c.497A>G": 1, "c.14825G>T": 1}}	\N
5934128	5933905	c.8926C>T/c.14693T>C	{"RYR1": {"c.8926C>T": 1, "c.14693T>C": 1}}	\N
5934129	5933905	c.10891G>T/c.14639T>C	{"RYR1": {"c.10891G>T": 1, "c.14639T>C": 1}}	\N
5934130	5933905	c.7771C>G/c.11953T>C	{"RYR1": {"c.7771C>G": 1, "c.11953T>C": 1}}	\N
5934131	5933905	c.6388G>A/c.15059G>C	{"RYR1": {"c.6388G>A": 1, "c.15059G>C": 1}}	\N
5934132	5933905	c.178G>T/c.190T>C	{"RYR1": {"c.178G>T": 1, "c.190T>C": 1}}	\N
5934133	5933905	c.533A>C/c.6544A>T	{"RYR1": {"c.533A>C": 1, "c.6544A>T": 1}}	\N
5934134	5933905	c.7089C>G/c.14051T>C	{"RYR1": {"c.7089C>G": 1, "c.14051T>C": 1}}	\N
5934135	5933905	c.7089C>G/c.11416G>A	{"RYR1": {"c.7089C>G": 1, "c.11416G>A": 1}}	\N
5934136	5933905	c.14582G>A/c.14582G>A	{"RYR1": {"c.14582G>A": 2}}	\N
5934137	5933905	c.1553T>C/c.14817C>A	{"RYR1": {"c.1553T>C": 1, "c.14817C>A": 1}}	\N
5934138	5933905	c.3172G>A/c.9635A>G	{"RYR1": {"c.3172G>A": 1, "c.9635A>G": 1}}	\N
5934139	5933905	c.2654G>A/c.12413T>C	{"RYR1": {"c.2654G>A": 1, "c.12413T>C": 1}}	\N
5934140	5933905	c.8654C>G/c.14968A>G	{"RYR1": {"c.8654C>G": 1, "c.14968A>G": 1}}	\N
5934141	5933905	c.8054C>T/c.11314C>T	{"RYR1": {"c.8054C>T": 1, "c.11314C>T": 1}}	\N
5934142	5933905	c.13934G>A/c.14364+1G>T	{"RYR1": {"c.13934G>A": 1, "c.14364+1G>T": 1}}	\N
5934143	5933905	c.6302T>A/c.14817C>A	{"RYR1": {"c.6302T>A": 1, "c.14817C>A": 1}}	\N
5934144	5933905	c.1422G>T/c.1459C>G	{"RYR1": {"c.1422G>T": 1, "c.1459C>G": 1}}	\N
5934145	5933905	c.3095G>A/c.8729C>T	{"RYR1": {"c.3095G>A": 1, "c.8729C>T": 1}}	\N
5934146	5933905	c.11748T>G/c.11953T>C	{"RYR1": {"c.11748T>G": 1, "c.11953T>C": 1}}	\N
5934147	5933905	c.3418C>T/c.9848G>A	{"RYR1": {"c.3418C>T": 1, "c.9848G>A": 1}}	\N
5934148	5933905	c.8290G>A/c.14422_14423delinsAA	{"RYR1": {"c.8290G>A": 1, "c.14422_14423delinsAA": 1}}	\N
5934149	5933905	c.1553T>C/c.7778G>A	{"RYR1": {"c.1553T>C": 1, "c.7778G>A": 1}}	\N
5934150	5933905	c.533A>C/c.641C>T	{"RYR1": {"c.533A>C": 1, "c.641C>T": 1}}	\N
5934151	5933905	c.5440A>G/c.14201G>A	{"RYR1": {"c.5440A>G": 1, "c.14201G>A": 1}}	\N
5934152	5933905	c.1459C>G/c.6388G>A	{"RYR1": {"c.1459C>G": 1, "c.6388G>A": 1}}	\N
5934153	5933905	c.3166G>A/c.10229C>A	{"RYR1": {"c.3166G>A": 1, "c.10229C>A": 1}}	\N
5934154	5933905	c.7355G>C/c.11813G>A	{"RYR1": {"c.7355G>C": 1, "c.11813G>A": 1}}	\N
5934155	5933905	c.14813T>C/c.14879T>A	{"RYR1": {"c.14813T>C": 1, "c.14879T>A": 1}}	\N
5934156	5933905	c.2654G>A/c.14422_14423delinsAA	{"RYR1": {"c.2654G>A": 1, "c.14422_14423delinsAA": 1}}	\N
5934157	5933905	c.14364+1G>T/c.14693T>C	{"RYR1": {"c.14693T>C": 1, "c.14364+1G>T": 1}}	\N
5934158	5933905	c.178G>T/c.6377G>A	{"RYR1": {"c.178G>T": 1, "c.6377G>A": 1}}	\N
5934159	5933905	c.119G>C/c.8527T>C	{"RYR1": {"c.119G>C": 1, "c.8527T>C": 1}}	\N
5934160	5933905	c.992_994dup/c.7018T>C	{"RYR1": {"c.7018T>C": 1, "c.992_994dup": 1}}	\N
5934161	5933905	c.8054C>T/c.8290G>A	{"RYR1": {"c.8054C>T": 1, "c.8290G>A": 1}}	\N
5934162	5933905	c.3166G>A/c.11314C>T	{"RYR1": {"c.3166G>A": 1, "c.11314C>T": 1}}	\N
5934163	5933905	c.533A>C/c.7210G>A	{"RYR1": {"c.533A>C": 1, "c.7210G>A": 1}}	\N
5934164	5933905	c.11958C>G/c.14582G>A	{"RYR1": {"c.11958C>G": 1, "c.14582G>A": 1}}	\N
5934165	5933905	c.8729C>T/c.14126C>T	{"RYR1": {"c.8729C>T": 1, "c.14126C>T": 1}}	\N
5934166	5933905	c.533A>C/c.9848G>A	{"RYR1": {"c.533A>C": 1, "c.9848G>A": 1}}	\N
5934167	5933905	c.10237A>T/c.11120G>T	{"RYR1": {"c.10237A>T": 1, "c.11120G>T": 1}}	\N
5934168	5933905	c.6388G>A/c.8005G>A	{"RYR1": {"c.6388G>A": 1, "c.8005G>A": 1}}	\N
5934169	5933905	c.496G>A/c.9499C>T	{"RYR1": {"c.496G>A": 1, "c.9499C>T": 1}}	\N
5934170	5933905	c.7018T>C/c.12242C>T	{"RYR1": {"c.7018T>C": 1, "c.12242C>T": 1}}	\N
5934171	5933905	c.8729C>T/c.9850T>A	{"RYR1": {"c.8729C>T": 1, "c.9850T>A": 1}}	\N
5934172	5933905	c.6599C>T/c.10891G>T	{"RYR1": {"c.6599C>T": 1, "c.10891G>T": 1}}	\N
5934173	5933905	c.4763C>T/c.6548G>A	{"RYR1": {"c.4763C>T": 1, "c.6548G>A": 1}}	\N
5934174	5933905	c.3656A>C/c.9868G>A	{"RYR1": {"c.3656A>C": 1, "c.9868G>A": 1}}	\N
5934175	5933905	c.6302T>A/c.7778G>A	{"RYR1": {"c.6302T>A": 1, "c.7778G>A": 1}}	\N
5934176	5933905	c.6635T>A/c.8527T>C	{"RYR1": {"c.6635T>A": 1, "c.8527T>C": 1}}	\N
5934177	5933905	c.8290G>A/c.14458G>A	{"RYR1": {"c.8290G>A": 1, "c.14458G>A": 1}}	\N
5934178	5933905	c.6388G>A/c.7317G>C	{"RYR1": {"c.6388G>A": 1, "c.7317G>C": 1}}	\N
5934179	5933905	c.51_53del/c.1209C>G	{"RYR1": {"c.1209C>G": 1, "c.51_53del": 1}}	\N
5934180	5933905	c.7760A>G/c.13760C>T	{"RYR1": {"c.7760A>G": 1, "c.13760C>T": 1}}	\N
5934181	5933905	c.1209C>G/c.11086G>C	{"RYR1": {"c.1209C>G": 1, "c.11086G>C": 1}}	\N
5934182	5933905	c.6742C>T/c.7099G>A	{"RYR1": {"c.6742C>T": 1, "c.7099G>A": 1}}	\N
5934183	5933905	c.677T>A/c.5132A>G	{"RYR1": {"c.677T>A": 1, "c.5132A>G": 1}}	\N
5934184	5933905	c.131G>A/c.7292A>T	{"RYR1": {"c.131G>A": 1, "c.7292A>T": 1}}	\N
5934185	5933905	c.3127C>T/c.6302T>A	{"RYR1": {"c.3127C>T": 1, "c.6302T>A": 1}}	\N
5934186	5933905	c.6548G>A/c.6671G>A	{"RYR1": {"c.6548G>A": 1, "c.6671G>A": 1}}	\N
5934187	5933905	c.526G>A/c.11132C>T	{"RYR1": {"c.526G>A": 1, "c.11132C>T": 1}}	\N
5934188	5933905	c.7771C>T/c.9758T>C	{"RYR1": {"c.7771C>T": 1, "c.9758T>C": 1}}	\N
5934189	5933905	c.7307G>A/c.14051T>C	{"RYR1": {"c.7307G>A": 1, "c.14051T>C": 1}}	\N
5934190	5933905	c.3656A>C/c.14449A>T	{"RYR1": {"c.3656A>C": 1, "c.14449A>T": 1}}	\N
5934191	5933905	c.8290G>A/c.14458G>T	{"RYR1": {"c.8290G>A": 1, "c.14458G>T": 1}}	\N
5934192	5933905	c.1201C>A/c.7760A>G	{"RYR1": {"c.1201C>A": 1, "c.7760A>G": 1}}	\N
5934193	5933905	c.528G>T/c.14126C>T	{"RYR1": {"c.528G>T": 1, "c.14126C>T": 1}}	\N
5934194	5933905	c.2996G>A/c.12242C>T	{"RYR1": {"c.2996G>A": 1, "c.12242C>T": 1}}	\N
5934195	5933905	c.6847A>C/c.10042C>T	{"RYR1": {"c.6847A>C": 1, "c.10042C>T": 1}}	\N
5934196	5933905	c.7307G>A/c.12355A>T	{"RYR1": {"c.7307G>A": 1, "c.12355A>T": 1}}	\N
5934197	5933905	c.493G>A/c.14678G>A	{"RYR1": {"c.493G>A": 1, "c.14678G>A": 1}}	\N
5934198	5933905	c.528G>T/c.9850T>A	{"RYR1": {"c.528G>T": 1, "c.9850T>A": 1}}	\N
5934199	5933905	c.641C>T/c.12413T>C	{"RYR1": {"c.641C>T": 1, "c.12413T>C": 1}}	\N
5934200	5933905	c.6757C>T/c.10891G>T	{"RYR1": {"c.6757C>T": 1, "c.10891G>T": 1}}	\N
5934201	5933905	c.533A>C/c.13990T>C	{"RYR1": {"c.533A>C": 1, "c.13990T>C": 1}}	\N
5934202	5933905	c.51_53del/c.12242C>T	{"RYR1": {"c.12242C>T": 1, "c.51_53del": 1}}	\N
5934203	5933905	c.2537C>T/c.7018T>C	{"RYR1": {"c.2537C>T": 1, "c.7018T>C": 1}}	\N
5934204	5933905	c.11126C>T/c.14558C>T	{"RYR1": {"c.11126C>T": 1, "c.14558C>T": 1}}	\N
5934205	5933905	c.7787C>T/c.11813G>A	{"RYR1": {"c.7787C>T": 1, "c.11813G>A": 1}}	\N
5934206	5933905	c.641C>T/c.14422_14423delinsAA	{"RYR1": {"c.641C>T": 1, "c.14422_14423delinsAA": 1}}	\N
5934207	5933905	c.8005G>A/c.8198G>A	{"RYR1": {"c.8005G>A": 1, "c.8198G>A": 1}}	\N
5934208	5933905	c.6304G>C/c.14968A>G	{"RYR1": {"c.6304G>C": 1, "c.14968A>G": 1}}	\N
5934209	5933905	c.8005G>A/c.11416G>A	{"RYR1": {"c.8005G>A": 1, "c.11416G>A": 1}}	\N
5934210	5933905	c.131G>A/c.14051T>C	{"RYR1": {"c.131G>A": 1, "c.14051T>C": 1}}	\N
5934211	5933905	c.652G>A/c.5186T>G	{"RYR1": {"c.652G>A": 1, "c.5186T>G": 1}}	\N
5934212	5933905	c.1475G>A/c.8188G>C	{"RYR1": {"c.1475G>A": 1, "c.8188G>C": 1}}	\N
5934213	5933905	c.641C>T/c.10237A>T	{"RYR1": {"c.641C>T": 1, "c.10237A>T": 1}}	\N
5934214	5933905	c.2654G>A/c.14458G>T	{"RYR1": {"c.2654G>A": 1, "c.14458G>T": 1}}	\N
5934215	5933905	c.251C>T/c.2924G>A	{"RYR1": {"c.251C>T": 1, "c.2924G>A": 1}}	\N
5934216	5933905	c.13994_13995delTCinsCT/c.14186A>C	{"RYR1": {"c.14186A>C": 1, "c.13994_13995delTCinsCT": 1}}	\N
5934217	5933905	c.488G>A/c.9850T>A	{"RYR1": {"c.488G>A": 1, "c.9850T>A": 1}}	\N
5934218	5933905	c.7879G>A/c.14782A>G	{"RYR1": {"c.7879G>A": 1, "c.14782A>G": 1}}	\N
5934219	5933905	c.7112A>G/c.7522C>G	{"RYR1": {"c.7112A>G": 1, "c.7522C>G": 1}}	\N
5934220	5933905	c.5441T>A/c.9797T>C	{"RYR1": {"c.5441T>A": 1, "c.9797T>C": 1}}	\N
5934221	5933905	c.8189A>G/c.14186A>C	{"RYR1": {"c.8189A>G": 1, "c.14186A>C": 1}}	\N
5934222	5933905	c.178G>T/c.11416G>A	{"RYR1": {"c.178G>T": 1, "c.11416G>A": 1}}	\N
5934223	5933905	c.8600T>A/c.12689T>G	{"RYR1": {"c.8600T>A": 1, "c.12689T>G": 1}}	\N
5934224	5933905	c.2654G>A/c.14458G>A	{"RYR1": {"c.2654G>A": 1, "c.14458G>A": 1}}	\N
5934225	5933905	c.946C>T/c.7777C>G	{"RYR1": {"c.946C>T": 1, "c.7777C>G": 1}}	\N
5934226	5933905	c.51_53del/c.14387A>G	{"RYR1": {"c.14387A>G": 1, "c.51_53del": 1}}	\N
5934227	5933905	c.14126C>T/c.14693T>C	{"RYR1": {"c.14126C>T": 1, "c.14693T>C": 1}}	\N
5934228	5933905	c.3656A>C/c.14509C>G	{"RYR1": {"c.3656A>C": 1, "c.14509C>G": 1}}	\N
5934229	5933905	c.7292A>T/c.8638G>A	{"RYR1": {"c.7292A>T": 1, "c.8638G>A": 1}}	\N
5934230	5933905	c.497A>G/c.13918A>G	{"RYR1": {"c.497A>G": 1, "c.13918A>G": 1}}	\N
5934231	5933905	c.10750G>C/c.12115A>T	{"RYR1": {"c.10750G>C": 1, "c.12115A>T": 1}}	\N
5934232	5933905	c.5186T>G/c.6640G>A	{"RYR1": {"c.5186T>G": 1, "c.6640G>A": 1}}	\N
5934233	5933905	c.1475G>A/c.12689T>G	{"RYR1": {"c.1475G>A": 1, "c.12689T>G": 1}}	\N
5934234	5933905	c.7099G>A/c.7199A>G	{"RYR1": {"c.7099G>A": 1, "c.7199A>G": 1}}	\N
5934235	5933905	c.152C>A/c.6640G>A	{"RYR1": {"c.152C>A": 1, "c.6640G>A": 1}}	\N
5934236	5933905	c.6742C>T/c.7771C>T	{"RYR1": {"c.6742C>T": 1, "c.7771C>T": 1}}	\N
5934237	5933905	c.488G>A/c.9268G>A	{"RYR1": {"c.488G>A": 1, "c.9268G>A": 1}}	\N
5934238	5933905	c.131G>A/c.11416G>A	{"RYR1": {"c.131G>A": 1, "c.11416G>A": 1}}	\N
5934239	5933905	c.10229C>A/c.14186A>C	{"RYR1": {"c.10229C>A": 1, "c.14186A>C": 1}}	\N
5934240	5933905	c.12848A>T/c.14582G>A	{"RYR1": {"c.12848A>T": 1, "c.14582G>A": 1}}	\N
5934241	5933905	c.12532G>A/c.12848A>T	{"RYR1": {"c.12532G>A": 1, "c.12848A>T": 1}}	\N
5934242	5933905	c.1598G>A/c.6635T>A	{"RYR1": {"c.1598G>A": 1, "c.6635T>A": 1}}	\N
5934243	5933905	c.190T>C/c.992_994dup	{"RYR1": {"c.190T>C": 1, "c.992_994dup": 1}}	\N
5934244	5933905	c.493G>A/c.8290G>A	{"RYR1": {"c.493G>A": 1, "c.8290G>A": 1}}	\N
5934245	5933905	c.1100G>A/c.5024T>C	{"RYR1": {"c.1100G>A": 1, "c.5024T>C": 1}}	\N
5934246	5933905	c.3656A>C/c.12064A>G	{"RYR1": {"c.3656A>C": 1, "c.12064A>G": 1}}	\N
5934247	5933905	c.1597C>A/c.4775C>T	{"RYR1": {"c.1597C>A": 1, "c.4775C>T": 1}}	\N
5934248	5933905	c.3095G>A/c.6478G>A	{"RYR1": {"c.3095G>A": 1, "c.6478G>A": 1}}	\N
5934249	5933905	c.6847A>C/c.11126C>T	{"RYR1": {"c.6847A>C": 1, "c.11126C>T": 1}}	\N
5934250	5933905	c.992_994dup/c.7085A>G	{"RYR1": {"c.7085A>G": 1, "c.992_994dup": 1}}	\N
5934251	5933905	c.8290G>A/c.12413T>C	{"RYR1": {"c.8290G>A": 1, "c.12413T>C": 1}}	\N
5934252	5933905	c.178G>T/c.1144C>A	{"RYR1": {"c.178G>T": 1, "c.1144C>A": 1}}	\N
5934253	5933905	c.12532G>A/c.15060G>C	{"RYR1": {"c.12532G>A": 1, "c.15060G>C": 1}}	\N
5934254	5933905	c.12689T>G/c.14424C>A	{"RYR1": {"c.12689T>G": 1, "c.14424C>A": 1}}	\N
5934255	5933905	c.8518C>T/c.14825G>T	{"RYR1": {"c.8518C>T": 1, "c.14825G>T": 1}}	\N
5934256	5933905	c.528G>T/c.9268G>A	{"RYR1": {"c.528G>T": 1, "c.9268G>A": 1}}	\N
5934257	5933905	c.10750G>C/c.14814C>G	{"RYR1": {"c.10750G>C": 1, "c.14814C>G": 1}}	\N
5934258	5933905	c.119G>C/c.8654C>G	{"RYR1": {"c.119G>C": 1, "c.8654C>G": 1}}	\N
5934259	5933905	c.8290G>A/c.10237A>T	{"RYR1": {"c.8290G>A": 1, "c.10237A>T": 1}}	\N
5934260	5933905	c.455C>A/c.677T>A	{"RYR1": {"c.455C>A": 1, "c.677T>A": 1}}	\N
5934261	5933905	c.6710G>A/c.8005G>A	{"RYR1": {"c.6710G>A": 1, "c.8005G>A": 1}}	\N
5934262	5933905	c.7487C>T/c.14825G>T	{"RYR1": {"c.7487C>T": 1, "c.14825G>T": 1}}	\N
5934263	5933905	c.7112A>G/c.13672C>T	{"RYR1": {"c.7112A>G": 1, "c.13672C>T": 1}}	\N
5934264	5933905	c.10043G>A/c.14678G>A	{"RYR1": {"c.10043G>A": 1, "c.14678G>A": 1}}	\N
5934265	5933905	c.13918A>G/c.14814C>G	{"RYR1": {"c.13918A>G": 1, "c.14814C>G": 1}}	\N
5934266	5933905	c.528G>T/c.1201C>A	{"RYR1": {"c.528G>T": 1, "c.1201C>A": 1}}	\N
5934267	5933905	c.12064A>G/c.14558C>T	{"RYR1": {"c.12064A>G": 1, "c.14558C>T": 1}}	\N
5934268	5933905	c.7112A>G/c.7787C>T	{"RYR1": {"c.7112A>G": 1, "c.7787C>T": 1}}	\N
5934269	5933905	c.9850T>A/c.13913G>A	{"RYR1": {"c.9850T>A": 1, "c.13913G>A": 1}}	\N
5934270	5933905	c.652G>A/c.6757C>T	{"RYR1": {"c.652G>A": 1, "c.6757C>T": 1}}	\N
5934271	5933905	c.1100G>A/c.7777C>G	{"RYR1": {"c.1100G>A": 1, "c.7777C>G": 1}}	\N
5934272	5933905	c.1201C>A/c.6037A>C	{"RYR1": {"c.1201C>A": 1, "c.6037A>C": 1}}	\N
5934273	5933905	c.12532G>A/c.15059G>C	{"RYR1": {"c.12532G>A": 1, "c.15059G>C": 1}}	\N
5934274	5933905	c.6302T>A/c.6847A>C	{"RYR1": {"c.6302T>A": 1, "c.6847A>C": 1}}	\N
5934275	5933905	c.7771C>G/c.13672C>T	{"RYR1": {"c.7771C>G": 1, "c.13672C>T": 1}}	\N
5934276	5933905	c.625G>A/c.14458G>A	{"RYR1": {"c.625G>A": 1, "c.14458G>A": 1}}	\N
5934277	5933905	c.1553T>C/c.6847A>C	{"RYR1": {"c.1553T>C": 1, "c.6847A>C": 1}}	\N
5934278	5933905	c.8729C>T/c.9268G>A	{"RYR1": {"c.8729C>T": 1, "c.9268G>A": 1}}	\N
5934279	5933905	c.11416G>A/c.14126C>T	{"RYR1": {"c.11416G>A": 1, "c.14126C>T": 1}}	\N
5934280	5933905	c.1598G>A/c.8600T>A	{"RYR1": {"c.1598G>A": 1, "c.8600T>A": 1}}	\N
5934281	5933905	c.2996G>A/c.14582G>A	{"RYR1": {"c.2996G>A": 1, "c.14582G>A": 1}}	\N
5934282	5933905	c.625G>A/c.14458G>T	{"RYR1": {"c.625G>A": 1, "c.14458G>T": 1}}	\N
5934283	5933905	c.2924G>A/c.9797T>C	{"RYR1": {"c.2924G>A": 1, "c.9797T>C": 1}}	\N
5934284	5933905	c.9848G>A/c.11953T>C	{"RYR1": {"c.9848G>A": 1, "c.11953T>C": 1}}	\N
5934285	5933905	c.4775C>T/c.14782A>G	{"RYR1": {"c.4775C>T": 1, "c.14782A>G": 1}}	\N
5934286	5933905	c.8518C>T/c.8518C>T	{"RYR1": {"c.8518C>T": 2}}	\N
5934287	5933905	c.11748T>G/c.13672C>T	{"RYR1": {"c.11748T>G": 1, "c.13672C>T": 1}}	\N
5934288	5933905	c.7018T>C/c.14582G>A	{"RYR1": {"c.7018T>C": 1, "c.14582G>A": 1}}	\N
5934289	5933905	c.7307G>A/c.7760A>G	{"RYR1": {"c.7307G>A": 1, "c.7760A>G": 1}}	\N
5934290	5933905	c.7760A>G/c.12398A>G	{"RYR1": {"c.7760A>G": 1, "c.12398A>G": 1}}	\N
5934291	5933905	c.7355G>A/c.11813G>A	{"RYR1": {"c.7355G>A": 1, "c.11813G>A": 1}}	\N
5934292	5933905	c.7089C>G/c.11813G>A	{"RYR1": {"c.7089C>G": 1, "c.11813G>A": 1}}	\N
5934293	5933905	c.1422G>T/c.4400A>G	{"RYR1": {"c.1422G>T": 1, "c.4400A>G": 1}}	\N
5934294	5933905	c.1024G>A/c.11132C>T	{"RYR1": {"c.1024G>A": 1, "c.11132C>T": 1}}	\N
5934295	5933905	c.528G>T/c.1201C>G	{"RYR1": {"c.528G>T": 1, "c.1201C>G": 1}}	\N
5934296	5933905	c.6037A>C/c.8518C>T	{"RYR1": {"c.6037A>C": 1, "c.8518C>T": 1}}	\N
5934297	5933905	c.2537C>T/c.7771C>G	{"RYR1": {"c.2537C>T": 1, "c.7771C>G": 1}}	\N
5934298	5933905	c.1411C>T/c.14449A>T	{"RYR1": {"c.1411C>T": 1, "c.14449A>T": 1}}	\N
5934299	5933905	c.12848A>T/c.14581C>T	{"RYR1": {"c.12848A>T": 1, "c.14581C>T": 1}}	\N
5934300	5933905	c.51_53del/c.467G>A	{"RYR1": {"c.467G>A": 1, "c.51_53del": 1}}	\N
5934301	5933905	c.51_53del/c.11518G>A	{"RYR1": {"c.11518G>A": 1, "c.51_53del": 1}}	\N
5934302	5933905	c.7032G>C/c.7760A>G	{"RYR1": {"c.7032G>C": 1, "c.7760A>G": 1}}	\N
5934303	5933905	c.11518G>A/c.13913G>A	{"RYR1": {"c.11518G>A": 1, "c.13913G>A": 1}}	\N
5934304	5933905	c.7307G>A/c.8198G>A	{"RYR1": {"c.7307G>A": 1, "c.8198G>A": 1}}	\N
5934305	5933905	c.7112A>G/c.11953T>C	{"RYR1": {"c.7112A>G": 1, "c.11953T>C": 1}}	\N
5934306	5933905	c.2537C>T/c.7771C>T	{"RYR1": {"c.2537C>T": 1, "c.7771C>T": 1}}	\N
5934307	5933905	c.3418C>T/c.9152G>A	{"RYR1": {"c.3418C>T": 1, "c.9152G>A": 1}}	\N
5934308	5933905	c.11314C>T/c.14186A>C	{"RYR1": {"c.11314C>T": 1, "c.14186A>C": 1}}	\N
5934309	5933905	c.9356G>A/c.11947C>T	{"RYR1": {"c.9356G>A": 1, "c.11947C>T": 1}}	\N
5934310	5933905	c.1597C>A/c.14817C>A	{"RYR1": {"c.1597C>A": 1, "c.14817C>A": 1}}	\N
5934311	5933905	c.479A>G/c.14825G>T	{"RYR1": {"c.479A>G": 1, "c.14825G>T": 1}}	\N
5934312	5933905	c.6544A>T/c.7073T>A	{"RYR1": {"c.6544A>T": 1, "c.7073T>A": 1}}	\N
5934313	5933905	c.5440A>G/c.6388G>A	{"RYR1": {"c.5440A>G": 1, "c.6388G>A": 1}}	\N
5934314	5933905	c.8527T>C/c.8926C>T	{"RYR1": {"c.8527T>C": 1, "c.8926C>T": 1}}	\N
5934315	5933905	c.6304G>C/c.14471T>C	{"RYR1": {"c.6304G>C": 1, "c.14471T>C": 1}}	\N
5934316	5933905	c.10252A>G/c.12064A>G	{"RYR1": {"c.10252A>G": 1, "c.12064A>G": 1}}	\N
5934317	5933905	c.7355G>C/c.13994_13995delTCinsCT	{"RYR1": {"c.7355G>C": 1, "c.13994_13995delTCinsCT": 1}}	\N
5934318	5933905	c.8527T>C/c.14126C>T	{"RYR1": {"c.8527T>C": 1, "c.14126C>T": 1}}	\N
5934319	5933905	c.680A>T/c.8198G>A	{"RYR1": {"c.680A>T": 1, "c.8198G>A": 1}}	\N
5934320	5933905	c.251C>T/c.6710G>A	{"RYR1": {"c.251C>T": 1, "c.6710G>A": 1}}	\N
5934321	5933905	c.10891G>T/c.11813G>A	{"RYR1": {"c.10891G>T": 1, "c.11813G>A": 1}}	\N
5934322	5933905	c.1553T>C/c.7199A>G	{"RYR1": {"c.1553T>C": 1, "c.7199A>G": 1}}	\N
5934323	5933905	c.10229C>A/c.13702C>G	{"RYR1": {"c.10229C>A": 1, "c.13702C>G": 1}}	\N
5934324	5933905	c.9848G>A/c.13672C>T	{"RYR1": {"c.9848G>A": 1, "c.13672C>T": 1}}	\N
5934325	5933905	c.2537C>T/c.9850T>A	{"RYR1": {"c.2537C>T": 1, "c.9850T>A": 1}}	\N
5934326	5933905	c.1453A>G/c.11416G>A	{"RYR1": {"c.1453A>G": 1, "c.11416G>A": 1}}	\N
5934327	5933905	c.1201C>G/c.13934G>A	{"RYR1": {"c.1201C>G": 1, "c.13934G>A": 1}}	\N
5934328	5933905	c.13702C>G/c.13994_13995delTCinsCT	{"RYR1": {"c.13702C>G": 1, "c.13994_13995delTCinsCT": 1}}	\N
5934329	5933905	c.152C>A/c.14471T>C	{"RYR1": {"c.152C>A": 1, "c.14471T>C": 1}}	\N
5934330	5933905	c.6847A>C/c.7760A>G	{"RYR1": {"c.6847A>C": 1, "c.7760A>G": 1}}	\N
5934331	5933905	c.6544A>T/c.11947C>T	{"RYR1": {"c.6544A>T": 1, "c.11947C>T": 1}}	\N
5934332	5933905	c.6635T>A/c.14814C>G	{"RYR1": {"c.6635T>A": 1, "c.14814C>G": 1}}	\N
5934333	5933905	c.467G>A/c.12553G>A	{"RYR1": {"c.467G>A": 1, "c.12553G>A": 1}}	\N
5934334	5933905	c.3667G>A/c.14814C>G	{"RYR1": {"c.3667G>A": 1, "c.14814C>G": 1}}	\N
5934335	5933905	c.4747C>T/c.5033A>G	{"RYR1": {"c.4747C>T": 1, "c.5033A>G": 1}}	\N
5934336	5933905	c.2654G>A/c.6548G>A	{"RYR1": {"c.2654G>A": 1, "c.6548G>A": 1}}	\N
5934337	5933905	c.6743G>A/c.11314C>T	{"RYR1": {"c.6743G>A": 1, "c.11314C>T": 1}}	\N
5934338	5933905	c.12553G>A/c.14424C>A	{"RYR1": {"c.12553G>A": 1, "c.14424C>A": 1}}	\N
5934339	5933905	c.526G>A/c.10891G>T	{"RYR1": {"c.526G>A": 1, "c.10891G>T": 1}}	\N
5934340	5933905	c.947G>T/c.13673G>A	{"RYR1": {"c.947G>T": 1, "c.13673G>A": 1}}	\N
5934341	5933905	c.4747C>T/c.11723A>T	{"RYR1": {"c.4747C>T": 1, "c.11723A>T": 1}}	\N
5934342	5933905	c.11947C>T/c.12028G>A	{"RYR1": {"c.11947C>T": 1, "c.12028G>A": 1}}	\N
5934343	5933905	c.1144C>A/c.11958C>G	{"RYR1": {"c.1144C>A": 1, "c.11958C>G": 1}}	\N
5934344	5933905	c.178G>A/c.7760A>G	{"RYR1": {"c.178G>A": 1, "c.7760A>G": 1}}	\N
5934345	5933905	c.3656A>C/c.7385C>T	{"RYR1": {"c.3656A>C": 1, "c.7385C>T": 1}}	\N
5934346	5933905	c.479A>G/c.496G>A	{"RYR1": {"c.479A>G": 1, "c.496G>A": 1}}	\N
5934347	5933905	c.2924G>A/c.10891G>T	{"RYR1": {"c.2924G>A": 1, "c.10891G>T": 1}}	\N
5934348	5933905	c.51_53del/c.1553T>C	{"RYR1": {"c.1553T>C": 1, "c.51_53del": 1}}	\N
5934349	5933905	c.652G>A/c.1201C>G	{"RYR1": {"c.652G>A": 1, "c.1201C>G": 1}}	\N
5934350	5933905	c.7787C>T/c.14639T>C	{"RYR1": {"c.7787C>T": 1, "c.14639T>C": 1}}	\N
5934351	5933905	c.652G>A/c.1201C>A	{"RYR1": {"c.652G>A": 1, "c.1201C>A": 1}}	\N
5934352	5933905	c.6635T>A/c.7317G>C	{"RYR1": {"c.6635T>A": 1, "c.7317G>C": 1}}	\N
5934353	5933905	c.946C>T/c.6847A>C	{"RYR1": {"c.946C>T": 1, "c.6847A>C": 1}}	\N
5934354	5933905	c.1597C>A/c.7778G>A	{"RYR1": {"c.1597C>A": 1, "c.7778G>A": 1}}	\N
5934355	5933905	c.641C>T/c.7032G>C	{"RYR1": {"c.641C>T": 1, "c.7032G>C": 1}}	\N
5934356	5933905	c.11958C>G/c.14387A>G	{"RYR1": {"c.11958C>G": 1, "c.14387A>G": 1}}	\N
5934357	5933905	c.1209C>G/c.8189A>G	{"RYR1": {"c.1209C>G": 1, "c.8189A>G": 1}}	\N
5934358	5933905	c.6548G>A/c.11086G>C	{"RYR1": {"c.6548G>A": 1, "c.11086G>C": 1}}	\N
5934359	5933905	c.7522C>G/c.14471T>C	{"RYR1": {"c.7522C>G": 1, "c.14471T>C": 1}}	\N
5934360	5933905	c.9797T>C/c.11748T>G	{"RYR1": {"c.9797T>C": 1, "c.11748T>G": 1}}	\N
5934361	5933905	c.12848A>T/c.13760C>T	{"RYR1": {"c.12848A>T": 1, "c.13760C>T": 1}}	\N
5934362	5933905	c.467G>A/c.14422_14423delinsAA	{"RYR1": {"c.467G>A": 1, "c.14422_14423delinsAA": 1}}	\N
5934363	5933905	c.497A>G/c.5132A>G	{"RYR1": {"c.497A>G": 1, "c.5132A>G": 1}}	\N
5934364	5933905	c.1201C>A/c.2050G>C	{"RYR1": {"c.1201C>A": 1, "c.2050G>C": 1}}	\N
5934365	5933905	c.14201G>A/c.14558C>T	{"RYR1": {"c.14201G>A": 1, "c.14558C>T": 1}}	\N
5934366	5933905	c.625G>A/c.3667G>A	{"RYR1": {"c.625G>A": 1, "c.3667G>A": 1}}	\N
5934367	5933905	c.7879G>A/c.14817C>A	{"RYR1": {"c.7879G>A": 1, "c.14817C>A": 1}}	\N
5934368	5933905	c.3667G>A/c.7317G>C	{"RYR1": {"c.3667G>A": 1, "c.7317G>C": 1}}	\N
5934369	5933905	c.6599C>T/c.11132C>T	{"RYR1": {"c.6599C>T": 1, "c.11132C>T": 1}}	\N
5934370	5933905	c.3527C>T/c.5033A>G	{"RYR1": {"c.3527C>T": 1, "c.5033A>G": 1}}	\N
5934371	5933905	c.7778G>A/c.9152G>A	{"RYR1": {"c.7778G>A": 1, "c.9152G>A": 1}}	\N
5934372	5933905	c.1597C>A/c.3667G>A	{"RYR1": {"c.1597C>A": 1, "c.3667G>A": 1}}	\N
5934373	5933905	c.11120G>T/c.11947C>T	{"RYR1": {"c.11120G>T": 1, "c.11947C>T": 1}}	\N
5934374	5933905	c.119G>C/c.9848G>A	{"RYR1": {"c.119G>C": 1, "c.9848G>A": 1}}	\N
5934375	5933905	c.455C>A/c.10229C>A	{"RYR1": {"c.455C>A": 1, "c.10229C>A": 1}}	\N
5934376	5933905	c.8198G>A/c.8638G>A	{"RYR1": {"c.8198G>A": 1, "c.8638G>A": 1}}	\N
5934377	5933905	c.488G>A/c.14524G>A	{"RYR1": {"c.488G>A": 1, "c.14524G>A": 1}}	\N
5934378	5933905	c.496G>A/c.8600T>A	{"RYR1": {"c.496G>A": 1, "c.8600T>A": 1}}	\N
5934379	5933905	c.7760A>G/c.12532G>A	{"RYR1": {"c.7760A>G": 1, "c.12532G>A": 1}}	\N
5934380	5933905	c.533A>C/c.8654C>G	{"RYR1": {"c.533A>C": 1, "c.8654C>G": 1}}	\N
5934381	5933905	c.467G>A/c.12413T>C	{"RYR1": {"c.467G>A": 1, "c.12413T>C": 1}}	\N
5934382	5933905	c.1144C>A/c.13672C>T	{"RYR1": {"c.1144C>A": 1, "c.13672C>T": 1}}	\N
5934383	5933905	c.641C>T/c.7199A>G	{"RYR1": {"c.641C>T": 1, "c.7199A>G": 1}}	\N
5934384	5933905	c.212C>A/c.11748T>G	{"RYR1": {"c.212C>A": 1, "c.11748T>G": 1}}	\N
5934385	5933905	c.7099G>A/c.14422_14423delinsAA	{"RYR1": {"c.7099G>A": 1, "c.14422_14423delinsAA": 1}}	\N
5934386	5933905	c.641C>T/c.3667G>A	{"RYR1": {"c.641C>T": 1, "c.3667G>A": 1}}	\N
5934387	5933905	c.7307G>A/c.11416G>A	{"RYR1": {"c.7307G>A": 1, "c.11416G>A": 1}}	\N
5934388	5933905	c.3527C>T/c.11723A>T	{"RYR1": {"c.3527C>T": 1, "c.11723A>T": 1}}	\N
5934389	5933905	c.947G>T/c.8054C>T	{"RYR1": {"c.947G>T": 1, "c.8054C>T": 1}}	\N
5934390	5933905	c.1201C>G/c.2050G>C	{"RYR1": {"c.1201C>G": 1, "c.2050G>C": 1}}	\N
5934391	5933905	c.11953T>C/c.15060G>C	{"RYR1": {"c.11953T>C": 1, "c.15060G>C": 1}}	\N
5934392	5933905	c.1597C>A/c.4763C>T	{"RYR1": {"c.1597C>A": 1, "c.4763C>T": 1}}	\N
5934393	5933905	c.7787C>T/c.12355A>T	{"RYR1": {"c.7787C>T": 1, "c.12355A>T": 1}}	\N
5934394	5933905	c.8527T>C/c.9268G>A	{"RYR1": {"c.8527T>C": 1, "c.9268G>A": 1}}	\N
5934395	5933905	c.2654G>A/c.10237A>T	{"RYR1": {"c.2654G>A": 1, "c.10237A>T": 1}}	\N
5934396	5933905	c.625G>A/c.11120G>T	{"RYR1": {"c.625G>A": 1, "c.11120G>T": 1}}	\N
5934397	5933905	c.680A>T/c.6304G>C	{"RYR1": {"c.680A>T": 1, "c.6304G>C": 1}}	\N
5934398	5933905	c.6377G>A/c.7522C>G	{"RYR1": {"c.6377G>A": 1, "c.7522C>G": 1}}	\N
5934399	5933905	c.7018T>C/c.11518G>A	{"RYR1": {"c.7018T>C": 1, "c.11518G>A": 1}}	\N
5934400	5933905	c.1597C>A/c.10237A>T	{"RYR1": {"c.1597C>A": 1, "c.10237A>T": 1}}	\N
5934401	5933905	c.12533G>T/c.12553G>A	{"RYR1": {"c.12533G>T": 1, "c.12553G>A": 1}}	\N
5934402	5933905	c.178G>A/c.190T>C	{"RYR1": {"c.178G>A": 1, "c.190T>C": 1}}	\N
5934403	5933905	c.5024T>C/c.7777C>G	{"RYR1": {"c.5024T>C": 1, "c.7777C>G": 1}}	\N
5934404	5933905	c.51_53del/c.946C>T	{"RYR1": {"c.946C>T": 1, "c.51_53del": 1}}	\N
5934405	5933905	c.1422G>T/c.7307G>A	{"RYR1": {"c.1422G>T": 1, "c.7307G>A": 1}}	\N
5934406	5933905	c.13760C>T/c.14449A>T	{"RYR1": {"c.13760C>T": 1, "c.14449A>T": 1}}	\N
5934407	5933905	c.1453A>G/c.7292A>T	{"RYR1": {"c.1453A>G": 1, "c.7292A>T": 1}}	\N
5934408	5933905	c.1834G>C/c.11518G>A	{"RYR1": {"c.1834G>C": 1, "c.11518G>A": 1}}	\N
5934409	5933905	c.947G>T/c.12689T>G	{"RYR1": {"c.947G>T": 1, "c.12689T>G": 1}}	\N
5934410	5933905	c.3127C>T/c.8189A>G	{"RYR1": {"c.3127C>T": 1, "c.8189A>G": 1}}	\N
5934411	5933905	c.178G>T/c.14051T>C	{"RYR1": {"c.178G>T": 1, "c.14051T>C": 1}}	\N
5934412	5933905	c.9635A>G/c.11132C>T	{"RYR1": {"c.9635A>G": 1, "c.11132C>T": 1}}	\N
5934413	5933905	c.5033A>G/c.14424C>A	{"RYR1": {"c.5033A>G": 1, "c.14424C>A": 1}}	\N
5934414	5933905	c.6671G>A/c.13913G>A	{"RYR1": {"c.6671G>A": 1, "c.13913G>A": 1}}	\N
5934415	5933905	c.479A>G/c.13918A>G	{"RYR1": {"c.479A>G": 1, "c.13918A>G": 1}}	\N
5934416	5933905	c.1453A>G/c.6304G>C	{"RYR1": {"c.1453A>G": 1, "c.6304G>C": 1}}	\N
5934417	5933905	c.9850T>A/c.12553G>A	{"RYR1": {"c.9850T>A": 1, "c.12553G>A": 1}}	\N
5934418	5933905	c.8005G>A/c.14051T>C	{"RYR1": {"c.8005G>A": 1, "c.14051T>C": 1}}	\N
5934419	5933905	c.11748T>G/c.12383C>T	{"RYR1": {"c.11748T>G": 1, "c.12383C>T": 1}}	\N
5934420	5933905	c.6599C>T/c.8729C>T	{"RYR1": {"c.6599C>T": 1, "c.8729C>T": 1}}	\N
5934421	5933905	c.7099G>A/c.12413T>C	{"RYR1": {"c.7099G>A": 1, "c.12413T>C": 1}}	\N
5934422	5933905	c.7879G>A/c.14693T>C	{"RYR1": {"c.7879G>A": 1, "c.14693T>C": 1}}	\N
5934423	5933905	c.7085A>G/c.12121C>T	{"RYR1": {"c.7085A>G": 1, "c.12121C>T": 1}}	\N
5934424	5933905	c.8600T>A/c.13913G>A	{"RYR1": {"c.8600T>A": 1, "c.13913G>A": 1}}	\N
5934425	5933905	c.6037A>C/c.13918A>G	{"RYR1": {"c.6037A>C": 1, "c.13918A>G": 1}}	\N
5934426	5933905	c.14051T>C/c.14825G>T	{"RYR1": {"c.14051T>C": 1, "c.14825G>T": 1}}	\N
5934427	5933905	c.2122G>A/c.10229C>A	{"RYR1": {"c.2122G>A": 1, "c.10229C>A": 1}}	\N
5934428	5933905	c.7075C>T/c.8290G>A	{"RYR1": {"c.7075C>T": 1, "c.8290G>A": 1}}	\N
5934429	5933905	c.131G>A/c.12355A>T	{"RYR1": {"c.131G>A": 1, "c.12355A>T": 1}}	\N
5934430	5933905	c.14567C>G/c.14567C>G	{"RYR1": {"c.14567C>G": 2}}	\N
5934431	5933905	c.7777C>G/c.14458G>T	{"RYR1": {"c.7777C>G": 1, "c.14458G>T": 1}}	\N
5934432	5933905	c.152C>A/c.5132A>G	{"RYR1": {"c.152C>A": 1, "c.5132A>G": 1}}	\N
5934433	5933905	c.7317G>C/c.11723A>T	{"RYR1": {"c.7317G>C": 1, "c.11723A>T": 1}}	\N
5934434	5933905	c.6377G>A/c.9649T>C	{"RYR1": {"c.6377G>A": 1, "c.9649T>C": 1}}	\N
5934435	5933905	c.1411C>T/c.1460T>C	{"RYR1": {"c.1411C>T": 1, "c.1460T>C": 1}}	\N
5934436	5933905	c.6544A>T/c.14458G>T	{"RYR1": {"c.6544A>T": 1, "c.14458G>T": 1}}	\N
5934437	5933905	c.533A>C/c.9499C>T	{"RYR1": {"c.533A>C": 1, "c.9499C>T": 1}}	\N
5934438	5933905	c.6377G>A/c.7787C>T	{"RYR1": {"c.6377G>A": 1, "c.7787C>T": 1}}	\N
5934439	5933905	c.13702C>G/c.14051T>C	{"RYR1": {"c.13702C>G": 1, "c.14051T>C": 1}}	\N
5934440	5933905	c.131G>A/c.190T>C	{"RYR1": {"c.131G>A": 1, "c.190T>C": 1}}	\N
5934441	5933905	c.14201G>A/c.14509C>G	{"RYR1": {"c.14201G>A": 1, "c.14509C>G": 1}}	\N
5934442	5933905	c.1453A>G/c.14051T>C	{"RYR1": {"c.1453A>G": 1, "c.14051T>C": 1}}	\N
5934443	5933905	c.493G>A/c.6599C>T	{"RYR1": {"c.493G>A": 1, "c.6599C>T": 1}}	\N
5934444	5933905	c.3667G>A/c.12848A>T	{"RYR1": {"c.3667G>A": 1, "c.12848A>T": 1}}	\N
5934445	5933905	c.1100G>T/c.14693T>C	{"RYR1": {"c.1100G>T": 1, "c.14693T>C": 1}}	\N
5934446	5933905	c.8600T>A/c.12383C>T	{"RYR1": {"c.8600T>A": 1, "c.12383C>T": 1}}	\N
5934447	5933905	c.2537C>T/c.13702C>G	{"RYR1": {"c.2537C>T": 1, "c.13702C>G": 1}}	\N
5934448	5933905	c.7777C>G/c.14458G>A	{"RYR1": {"c.7777C>G": 1, "c.14458G>A": 1}}	\N
5934449	5933905	c.11953T>C/c.15059G>C	{"RYR1": {"c.11953T>C": 1, "c.15059G>C": 1}}	\N
5934450	5933905	c.3127C>T/c.14813T>C	{"RYR1": {"c.3127C>T": 1, "c.14813T>C": 1}}	\N
5934451	5933905	c.1024G>A/c.6478G>A	{"RYR1": {"c.1024G>A": 1, "c.6478G>A": 1}}	\N
5934452	5933905	c.1453A>G/c.13994_13995delTCinsCT	{"RYR1": {"c.1453A>G": 1, "c.13994_13995delTCinsCT": 1}}	\N
5934453	5933905	c.6743G>A/c.10229C>A	{"RYR1": {"c.6743G>A": 1, "c.10229C>A": 1}}	\N
5934454	5933905	c.2122G>A/c.3095G>A	{"RYR1": {"c.2122G>A": 1, "c.3095G>A": 1}}	\N
5934455	5933905	c.496G>A/c.9356G>A	{"RYR1": {"c.496G>A": 1, "c.9356G>A": 1}}	\N
5934456	5933905	c.5186T>G/c.8518C>T	{"RYR1": {"c.5186T>G": 1, "c.8518C>T": 1}}	\N
5934457	5933905	c.496G>A/c.13990T>C	{"RYR1": {"c.496G>A": 1, "c.13990T>C": 1}}	\N
5934458	5933905	c.11813G>A/c.14002C>T	{"RYR1": {"c.11813G>A": 1, "c.14002C>T": 1}}	\N
5934459	5933905	c.7210G>A/c.14818G>A	{"RYR1": {"c.7210G>A": 1, "c.14818G>A": 1}}	\N
5934460	5933905	c.2122G>A/c.3166G>A	{"RYR1": {"c.2122G>A": 1, "c.3166G>A": 1}}	\N
5934461	5933905	c.6544A>T/c.14458G>A	{"RYR1": {"c.6544A>T": 1, "c.14458G>A": 1}}	\N
5934462	5933905	c.1597C>A/c.11120G>T	{"RYR1": {"c.1597C>A": 1, "c.11120G>T": 1}}	\N
5934463	5933905	c.14270G>A/c.14818G>A	{"RYR1": {"c.14270G>A": 1, "c.14818G>A": 1}}	\N
5934464	5933905	c.1459C>G/c.10043G>A	{"RYR1": {"c.1459C>G": 1, "c.10043G>A": 1}}	\N
5934465	5933905	c.1201C>A/c.12355A>T	{"RYR1": {"c.1201C>A": 1, "c.12355A>T": 1}}	\N
5934466	5933905	c.9797T>C/c.11953T>C	{"RYR1": {"c.9797T>C": 1, "c.11953T>C": 1}}	\N
5934467	5933905	c.5440A>G/c.6037A>C	{"RYR1": {"c.5440A>G": 1, "c.6037A>C": 1}}	\N
5934468	5933905	c.1834G>C/c.14387A>G	{"RYR1": {"c.1834G>C": 1, "c.14387A>G": 1}}	\N
5934469	5933905	c.2654G>A/c.2654G>A	{"RYR1": {"c.2654G>A": 2}}	\N
5934470	5933905	c.11518G>A/c.11947C>T	{"RYR1": {"c.11518G>A": 1, "c.11947C>T": 1}}	\N
5934471	5933905	c.2996G>A/c.14002C>T	{"RYR1": {"c.2996G>A": 1, "c.14002C>T": 1}}	\N
5934472	5933905	c.7112A>G/c.7487C>T	{"RYR1": {"c.7112A>G": 1, "c.7487C>T": 1}}	\N
5934473	5933905	c.13673G>A/c.14582G>A	{"RYR1": {"c.13673G>A": 1, "c.14582G>A": 1}}	\N
5934474	5933905	c.14449A>T/c.14678G>A	{"RYR1": {"c.14449A>T": 1, "c.14678G>A": 1}}	\N
5934475	5933905	c.14458G>T/c.14582G>A	{"RYR1": {"c.14458G>T": 1, "c.14582G>A": 1}}	\N
5934476	5933905	c.12242C>T/c.12355A>T	{"RYR1": {"c.12242C>T": 1, "c.12355A>T": 1}}	\N
5934477	5933905	c.1411C>T/c.7879G>A	{"RYR1": {"c.1411C>T": 1, "c.7879G>A": 1}}	\N
5934478	5933905	c.1553T>C/c.14782A>G	{"RYR1": {"c.1553T>C": 1, "c.14782A>G": 1}}	\N
5934479	5933905	c.5132A>G/c.6743G>A	{"RYR1": {"c.5132A>G": 1, "c.6743G>A": 1}}	\N
5934480	5933905	c.3166G>A/c.12533G>T	{"RYR1": {"c.3166G>A": 1, "c.12533G>T": 1}}	\N
5934481	5933905	c.178G>A/c.10042C>T	{"RYR1": {"c.178G>A": 1, "c.10042C>T": 1}}	\N
5934482	5933905	c.6377G>A/c.7487C>T	{"RYR1": {"c.6377G>A": 1, "c.7487C>T": 1}}	\N
5934483	5933905	c.9499C>T/c.14051T>C	{"RYR1": {"c.9499C>T": 1, "c.14051T>C": 1}}	\N
5934484	5933905	c.7097C>G/c.12413T>C	{"RYR1": {"c.7097C>G": 1, "c.12413T>C": 1}}	\N
5934485	5933905	c.119G>C/c.7210G>A	{"RYR1": {"c.119G>C": 1, "c.7210G>A": 1}}	\N
5934486	5933905	c.7032G>C/c.14201G>A	{"RYR1": {"c.7032G>C": 1, "c.14201G>A": 1}}	\N
5934487	5933905	c.5132A>G/c.13505A>G	{"RYR1": {"c.5132A>G": 1, "c.13505A>G": 1}}	\N
5934488	5933905	c.5441T>A/c.7777C>G	{"RYR1": {"c.5441T>A": 1, "c.7777C>G": 1}}	\N
5934489	5933905	c.11723A>T/c.11723A>T	{"RYR1": {"c.11723A>T": 2}}	\N
5934490	5933905	c.5890C>T/c.7778G>A	{"RYR1": {"c.5890C>T": 1, "c.7778G>A": 1}}	\N
5934491	5933905	c.7075C>T/c.12533G>T	{"RYR1": {"c.7075C>T": 1, "c.12533G>T": 1}}	\N
5934492	5933905	c.8518C>T/c.13918A>G	{"RYR1": {"c.8518C>T": 1, "c.13918A>G": 1}}	\N
5934493	5933905	c.2654G>A/c.7073T>A	{"RYR1": {"c.2654G>A": 1, "c.7073T>A": 1}}	\N
5934494	5933905	c.7097C>G/c.14422_14423delinsAA	{"RYR1": {"c.7097C>G": 1, "c.14422_14423delinsAA": 1}}	\N
5934495	5933905	c.12689T>G/c.14678G>A	{"RYR1": {"c.12689T>G": 1, "c.14678G>A": 1}}	\N
5934496	5933905	c.1411C>T/c.5890C>T	{"RYR1": {"c.1411C>T": 1, "c.5890C>T": 1}}	\N
5934497	5933905	c.7075C>T/c.11314C>T	{"RYR1": {"c.7075C>T": 1, "c.11314C>T": 1}}	\N
5934498	5933905	c.1144C>A/c.7522C>G	{"RYR1": {"c.1144C>A": 1, "c.7522C>G": 1}}	\N
5934499	5933905	c.1460T>C/c.9797T>C	{"RYR1": {"c.1460T>C": 1, "c.9797T>C": 1}}	\N
5934500	5933905	c.488G>A/c.3418C>T	{"RYR1": {"c.488G>A": 1, "c.3418C>T": 1}}	\N
5934501	5933905	c.5341T>C/c.7777C>G	{"RYR1": {"c.5341T>C": 1, "c.7777C>G": 1}}	\N
5934502	5933905	c.1459C>G/c.7075C>T	{"RYR1": {"c.1459C>G": 1, "c.7075C>T": 1}}	\N
5934503	5933905	c.190T>C/c.11723A>T	{"RYR1": {"c.190T>C": 1, "c.11723A>T": 1}}	\N
5934504	5933905	c.526G>A/c.8189A>G	{"RYR1": {"c.526G>A": 1, "c.8189A>G": 1}}	\N
5934505	5933905	c.625G>A/c.7199A>G	{"RYR1": {"c.625G>A": 1, "c.7199A>G": 1}}	\N
5934506	5933905	c.1460T>C/c.1475G>A	{"RYR1": {"c.1460T>C": 1, "c.1475G>A": 1}}	\N
5934507	5933905	c.14186A>C/c.14678G>A	{"RYR1": {"c.14186A>C": 1, "c.14678G>A": 1}}	\N
5934508	5933905	c.1411C>T/c.8926C>T	{"RYR1": {"c.1411C>T": 1, "c.8926C>T": 1}}	\N
5934509	5933905	c.7085A>G/c.14567C>G	{"RYR1": {"c.7085A>G": 1, "c.14567C>G": 1}}	\N
5934510	5933905	c.496G>A/c.9152G>A	{"RYR1": {"c.496G>A": 1, "c.9152G>A": 1}}	\N
5934511	5933905	c.11748T>G/c.12689T>G	{"RYR1": {"c.11748T>G": 1, "c.12689T>G": 1}}	\N
5934512	5933905	c.7778G>A/c.13990T>C	{"RYR1": {"c.7778G>A": 1, "c.13990T>C": 1}}	\N
5934513	5933905	c.12121C>T/c.14817C>A	{"RYR1": {"c.12121C>T": 1, "c.14817C>A": 1}}	\N
5934514	5933905	c.4400A>G/c.11723A>T	{"RYR1": {"c.4400A>G": 1, "c.11723A>T": 1}}	\N
5934515	5933905	c.7355G>A/c.12848A>T	{"RYR1": {"c.7355G>A": 1, "c.12848A>T": 1}}	\N
5934516	5933905	c.12383C>T/c.14471T>C	{"RYR1": {"c.12383C>T": 1, "c.14471T>C": 1}}	\N
5934517	5933905	c.6388G>A/c.14814C>G	{"RYR1": {"c.6388G>A": 1, "c.14814C>G": 1}}	\N
5934518	5933905	c.1201C>G/c.12355A>T	{"RYR1": {"c.1201C>G": 1, "c.12355A>T": 1}}	\N
5934519	5933905	c.5890C>T/c.14817C>A	{"RYR1": {"c.5890C>T": 1, "c.14817C>A": 1}}	\N
5934520	5933905	c.7085A>G/c.14813T>C	{"RYR1": {"c.7085A>G": 1, "c.14813T>C": 1}}	\N
5934521	5933905	c.1100G>T/c.5024T>C	{"RYR1": {"c.1100G>T": 1, "c.5024T>C": 1}}	\N
5934522	5933905	c.947G>T/c.11748T>G	{"RYR1": {"c.947G>T": 1, "c.11748T>G": 1}}	\N
5934523	5933905	c.7771C>T/c.13672C>T	{"RYR1": {"c.7771C>T": 1, "c.13672C>T": 1}}	\N
5934524	5933905	c.6635T>A/c.7210G>A	{"RYR1": {"c.6635T>A": 1, "c.7210G>A": 1}}	\N
5934525	5933905	c.10252A>G/c.14558C>T	{"RYR1": {"c.10252A>G": 1, "c.14558C>T": 1}}	\N
5934526	5933905	c.11126C>T/c.14449A>T	{"RYR1": {"c.11126C>T": 1, "c.14449A>T": 1}}	\N
5934527	5933905	c.528G>T/c.5890C>T	{"RYR1": {"c.528G>T": 1, "c.5890C>T": 1}}	\N
5934528	5933905	c.9268G>A/c.14458G>T	{"RYR1": {"c.9268G>A": 1, "c.14458G>T": 1}}	\N
5934529	5933905	c.1475G>A/c.9649T>C	{"RYR1": {"c.1475G>A": 1, "c.9649T>C": 1}}	\N
5934530	5933905	c.7199A>G/c.14879T>A	{"RYR1": {"c.7199A>G": 1, "c.14879T>A": 1}}	\N
5934531	5933905	c.3095G>A/c.6671G>A	{"RYR1": {"c.3095G>A": 1, "c.6671G>A": 1}}	\N
5934532	5933905	c.1598G>A/c.9152G>A	{"RYR1": {"c.1598G>A": 1, "c.9152G>A": 1}}	\N
5934533	5933905	c.12028G>A/c.13672C>T	{"RYR1": {"c.12028G>A": 1, "c.13672C>T": 1}}	\N
5934534	5933905	c.10252A>G/c.10750G>C	{"RYR1": {"c.10252A>G": 1, "c.10750G>C": 1}}	\N
5934535	5933905	c.14197T>G/c.14449A>T	{"RYR1": {"c.14197T>G": 1, "c.14449A>T": 1}}	\N
5934536	5933905	c.3172G>A/c.14270G>A	{"RYR1": {"c.3172G>A": 1, "c.14270G>A": 1}}	\N
5934537	5933905	c.528G>T/c.8926C>T	{"RYR1": {"c.528G>T": 1, "c.8926C>T": 1}}	\N
5934538	5933905	c.7760A>G/c.14002C>T	{"RYR1": {"c.7760A>G": 1, "c.14002C>T": 1}}	\N
5934539	5933905	c.251C>T/c.5890C>T	{"RYR1": {"c.251C>T": 1, "c.5890C>T": 1}}	\N
5934540	5933905	c.5440A>G/c.10042C>T	{"RYR1": {"c.5440A>G": 1, "c.10042C>T": 1}}	\N
5934541	5933905	c.3127C>T/c.12121C>T	{"RYR1": {"c.3127C>T": 1, "c.12121C>T": 1}}	\N
5934542	5933905	c.1598G>A/c.8054C>T	{"RYR1": {"c.1598G>A": 1, "c.8054C>T": 1}}	\N
5934543	5933905	c.467G>A/c.7032G>C	{"RYR1": {"c.467G>A": 1, "c.7032G>C": 1}}	\N
5934544	5933905	c.8198G>A/c.12064A>G	{"RYR1": {"c.8198G>A": 1, "c.12064A>G": 1}}	\N
5934545	5933905	c.8005G>A/c.14639T>C	{"RYR1": {"c.8005G>A": 1, "c.14639T>C": 1}}	\N
5934546	5933905	c.625G>A/c.7032G>C	{"RYR1": {"c.625G>A": 1, "c.7032G>C": 1}}	\N
5934547	5933905	c.131G>A/c.11126C>T	{"RYR1": {"c.131G>A": 1, "c.11126C>T": 1}}	\N
5934548	5933905	c.9268G>A/c.14458G>A	{"RYR1": {"c.9268G>A": 1, "c.14458G>A": 1}}	\N
5934549	5933905	c.10237A>T/c.10237A>T	{"RYR1": {"c.10237A>T": 2}}	\N
5934550	5933905	c.8189A>G/c.10556C>T	{"RYR1": {"c.8189A>G": 1, "c.10556C>T": 1}}	\N
5934551	5933905	c.131G>A/c.2050G>C	{"RYR1": {"c.131G>A": 1, "c.2050G>C": 1}}	\N
5934552	5933905	c.14387A>G/c.14968A>G	{"RYR1": {"c.14387A>G": 1, "c.14968A>G": 1}}	\N
5934553	5933905	c.8290G>A/c.14818G>A	{"RYR1": {"c.8290G>A": 1, "c.14818G>A": 1}}	\N
5934554	5933905	c.526G>A/c.8729C>T	{"RYR1": {"c.526G>A": 1, "c.8729C>T": 1}}	\N
5934555	5933905	c.12064A>G/c.14509C>G	{"RYR1": {"c.12064A>G": 1, "c.14509C>G": 1}}	\N
5934556	5933905	c.11958C>G/c.12532G>A	{"RYR1": {"c.11958C>G": 1, "c.12532G>A": 1}}	\N
5934557	5933905	c.497A>G/c.3527C>T	{"RYR1": {"c.497A>G": 1, "c.3527C>T": 1}}	\N
5934558	5933905	c.1834G>C/c.10252A>G	{"RYR1": {"c.1834G>C": 1, "c.10252A>G": 1}}	\N
5934559	5933905	c.992_994dup/c.1201C>G	{"RYR1": {"c.1201C>G": 1, "c.992_994dup": 1}}	\N
5934560	5933905	c.178G>T/c.14639T>C	{"RYR1": {"c.178G>T": 1, "c.14639T>C": 1}}	\N
5934561	5933905	c.479A>G/c.8518C>T	{"RYR1": {"c.479A>G": 1, "c.8518C>T": 1}}	\N
5934562	5933905	c.7355G>C/c.12848A>T	{"RYR1": {"c.7355G>C": 1, "c.12848A>T": 1}}	\N
5934563	5933905	c.251C>T/c.8926C>T	{"RYR1": {"c.251C>T": 1, "c.8926C>T": 1}}	\N
5934564	5933905	c.992_994dup/c.1201C>A	{"RYR1": {"c.1201C>A": 1, "c.992_994dup": 1}}	\N
5934565	5933905	c.1209C>G/c.8729C>T	{"RYR1": {"c.1209C>G": 1, "c.8729C>T": 1}}	\N
5934566	5933905	c.467G>A/c.488G>A	{"RYR1": {"c.467G>A": 1, "c.488G>A": 1}}	\N
5934567	5933905	c.1201C>G/c.11126C>T	{"RYR1": {"c.1201C>G": 1, "c.11126C>T": 1}}	\N
5934568	5933905	c.8198G>A/c.14449A>T	{"RYR1": {"c.8198G>A": 1, "c.14449A>T": 1}}	\N
5934569	5933905	c.178G>A/c.6037A>C	{"RYR1": {"c.178G>A": 1, "c.6037A>C": 1}}	\N
5934570	5933905	c.677T>A/c.6640G>A	{"RYR1": {"c.677T>A": 1, "c.6640G>A": 1}}	\N
5934571	5933905	c.2050G>C/c.11947C>T	{"RYR1": {"c.2050G>C": 1, "c.11947C>T": 1}}	\N
5934572	5933905	c.8188G>C/c.13994_13995delTCinsCT	{"RYR1": {"c.8188G>C": 1, "c.13994_13995delTCinsCT": 1}}	\N
5934573	5933905	c.4763C>T/c.12413T>C	{"RYR1": {"c.4763C>T": 1, "c.12413T>C": 1}}	\N
5934574	5933905	c.2050G>C/c.7073T>A	{"RYR1": {"c.2050G>C": 1, "c.7073T>A": 1}}	\N
5934575	5933905	c.10750G>C/c.13994_13995delTCinsCT	{"RYR1": {"c.10750G>C": 1, "c.13994_13995delTCinsCT": 1}}	\N
5934576	5933905	c.131G>A/c.5441T>A	{"RYR1": {"c.131G>A": 1, "c.5441T>A": 1}}	\N
5934577	5933905	c.7199A>G/c.14968A>G	{"RYR1": {"c.7199A>G": 1, "c.14968A>G": 1}}	\N
5934578	5933905	c.9635A>G/c.14567C>G	{"RYR1": {"c.9635A>G": 1, "c.14567C>G": 1}}	\N
5934579	5933905	c.2050G>C/c.4400A>G	{"RYR1": {"c.2050G>C": 1, "c.4400A>G": 1}}	\N
5934580	5933905	c.652G>A/c.8926C>T	{"RYR1": {"c.652G>A": 1, "c.8926C>T": 1}}	\N
5934581	5933905	c.1201C>A/c.13934G>A	{"RYR1": {"c.1201C>A": 1, "c.13934G>A": 1}}	\N
5934582	5933905	c.641C>T/c.11120G>T	{"RYR1": {"c.641C>T": 1, "c.11120G>T": 1}}	\N
5934583	5933905	c.1144C>A/c.7787C>T	{"RYR1": {"c.1144C>A": 1, "c.7787C>T": 1}}	\N
5934584	5933905	c.8054C>T/c.12533G>T	{"RYR1": {"c.8054C>T": 1, "c.12533G>T": 1}}	\N
5934585	5933905	c.251C>T/c.7879G>A	{"RYR1": {"c.251C>T": 1, "c.7879G>A": 1}}	\N
5934586	5933905	c.3418C>T/c.13990T>C	{"RYR1": {"c.3418C>T": 1, "c.13990T>C": 1}}	\N
5934587	5933905	c.1422G>T/c.2654G>A	{"RYR1": {"c.1422G>T": 1, "c.2654G>A": 1}}	\N
5934588	5933905	c.947G>T/c.12383C>T	{"RYR1": {"c.947G>T": 1, "c.12383C>T": 1}}	\N
5934589	5933905	c.652G>A/c.5890C>T	{"RYR1": {"c.652G>A": 1, "c.5890C>T": 1}}	\N
5934590	5933905	c.1834G>C/c.12242C>T	{"RYR1": {"c.1834G>C": 1, "c.12242C>T": 1}}	\N
5934591	5933905	c.4763C>T/c.12553G>A	{"RYR1": {"c.4763C>T": 1, "c.12553G>A": 1}}	\N
5934592	5933905	c.7018T>C/c.13760C>T	{"RYR1": {"c.7018T>C": 1, "c.13760C>T": 1}}	\N
5934593	5933905	c.7760A>G/c.14582G>A	{"RYR1": {"c.7760A>G": 1, "c.14582G>A": 1}}	\N
5934594	5933905	c.190T>C/c.10750G>C	{"RYR1": {"c.190T>C": 1, "c.10750G>C": 1}}	\N
5934595	5933905	c.6671G>A/c.9758T>C	{"RYR1": {"c.6671G>A": 1, "c.9758T>C": 1}}	\N
5934596	5933905	c.6304G>C/c.6640G>A	{"RYR1": {"c.6304G>C": 1, "c.6640G>A": 1}}	\N
5934597	5933905	c.6671G>A/c.11947C>T	{"RYR1": {"c.6671G>A": 1, "c.11947C>T": 1}}	\N
5934598	5933905	c.178G>T/c.5441T>A	{"RYR1": {"c.178G>T": 1, "c.5441T>A": 1}}	\N
5934599	5933905	c.1459C>G/c.14471T>C	{"RYR1": {"c.1459C>G": 1, "c.14471T>C": 1}}	\N
5934600	5933905	c.6671G>A/c.7073T>A	{"RYR1": {"c.6671G>A": 1, "c.7073T>A": 1}}	\N
5934601	5933905	c.8729C>T/c.14825G>T	{"RYR1": {"c.8729C>T": 1, "c.14825G>T": 1}}	\N
5934602	5933905	c.7487C>T/c.9268G>A	{"RYR1": {"c.7487C>T": 1, "c.9268G>A": 1}}	\N
5934603	5933905	c.992_994dup/c.3527C>T	{"RYR1": {"c.3527C>T": 1, "c.992_994dup": 1}}	\N
5934604	5933905	c.496G>A/c.641C>T	{"RYR1": {"c.496G>A": 1, "c.641C>T": 1}}	\N
5934605	5933905	c.119G>C/c.6544A>T	{"RYR1": {"c.119G>C": 1, "c.6544A>T": 1}}	\N
5934606	5933905	c.3667G>A/c.8005G>A	{"RYR1": {"c.3667G>A": 1, "c.8005G>A": 1}}	\N
5934607	5933905	c.119G>C/c.7089C>G	{"RYR1": {"c.119G>C": 1, "c.7089C>G": 1}}	\N
5934608	5933905	c.488G>A/c.7085A>G	{"RYR1": {"c.488G>A": 1, "c.7085A>G": 1}}	\N
5934609	5933905	c.2050G>C/c.9758T>C	{"RYR1": {"c.2050G>C": 1, "c.9758T>C": 1}}	\N
5934610	5933905	c.7292A>T/c.7385C>T	{"RYR1": {"c.7292A>T": 1, "c.7385C>T": 1}}	\N
5934611	5933905	c.5890C>T/c.6847A>C	{"RYR1": {"c.5890C>T": 1, "c.6847A>C": 1}}	\N
5934612	5933905	c.9652G>A/c.12028G>A	{"RYR1": {"c.9652G>A": 1, "c.12028G>A": 1}}	\N
5934613	5933905	c.178G>A/c.11813G>A	{"RYR1": {"c.178G>A": 1, "c.11813G>A": 1}}	\N
5934614	5933905	c.488G>A/c.7018T>C	{"RYR1": {"c.488G>A": 1, "c.7018T>C": 1}}	\N
5934615	5933905	c.5186T>G/c.14968A>G	{"RYR1": {"c.5186T>G": 1, "c.14968A>G": 1}}	\N
5934616	5933905	c.2996G>A/c.13505A>G	{"RYR1": {"c.2996G>A": 1, "c.13505A>G": 1}}	\N
5934617	5933905	c.9649T>C/c.14197T>G	{"RYR1": {"c.9649T>C": 1, "c.14197T>G": 1}}	\N
5934618	5933905	c.14126C>T/c.14817C>A	{"RYR1": {"c.14126C>T": 1, "c.14817C>A": 1}}	\N
5934619	5933905	c.488G>A/c.7099G>A	{"RYR1": {"c.488G>A": 1, "c.7099G>A": 1}}	\N
5934620	5933905	c.1453A>G/c.2122G>A	{"RYR1": {"c.1453A>G": 1, "c.2122G>A": 1}}	\N
5934621	5933905	c.1024G>A/c.8729C>T	{"RYR1": {"c.1024G>A": 1, "c.8729C>T": 1}}	\N
5934622	5933905	c.9499C>T/c.11416G>A	{"RYR1": {"c.9499C>T": 1, "c.11416G>A": 1}}	\N
5934623	5933905	c.992_994dup/c.9850T>A	{"RYR1": {"c.9850T>A": 1, "c.992_994dup": 1}}	\N
5934624	5933905	c.9797T>C/c.12383C>T	{"RYR1": {"c.9797T>C": 1, "c.12383C>T": 1}}	\N
5934625	5933905	c.7085A>G/c.8189A>G	{"RYR1": {"c.7085A>G": 1, "c.8189A>G": 1}}	\N
5934626	5933905	c.4775C>T/c.14818G>A	{"RYR1": {"c.4775C>T": 1, "c.14818G>A": 1}}	\N
5934627	5933905	c.6478G>A/c.11086G>C	{"RYR1": {"c.6478G>A": 1, "c.11086G>C": 1}}	\N
5934628	5933905	c.1475G>A/c.7787C>T	{"RYR1": {"c.1475G>A": 1, "c.7787C>T": 1}}	\N
5934629	5933905	c.1453A>G/c.8198G>A	{"RYR1": {"c.1453A>G": 1, "c.8198G>A": 1}}	\N
5934630	5933905	c.2924G>A/c.11132C>T	{"RYR1": {"c.2924G>A": 1, "c.11132C>T": 1}}	\N
5934631	5933905	c.5440A>G/c.14879T>A	{"RYR1": {"c.5440A>G": 1, "c.14879T>A": 1}}	\N
5934632	5933905	c.11813G>A/c.14567C>G	{"RYR1": {"c.11813G>A": 1, "c.14567C>G": 1}}	\N
5934633	5933905	c.11947C>T/c.14680G>A	{"RYR1": {"c.11947C>T": 1, "c.14680G>A": 1}}	\N
5934634	5933905	c.13672C>T/c.14449A>T	{"RYR1": {"c.13672C>T": 1, "c.14449A>T": 1}}	\N
5934635	5933905	c.2122G>A/c.14680G>A	{"RYR1": {"c.2122G>A": 1, "c.14680G>A": 1}}	\N
5934636	5933905	c.992_994dup/c.13702C>G	{"RYR1": {"c.13702C>G": 1, "c.992_994dup": 1}}	\N
5934637	5933905	c.3667G>A/c.4747C>T	{"RYR1": {"c.3667G>A": 1, "c.4747C>T": 1}}	\N
5934638	5933905	c.2996G>A/c.12532G>A	{"RYR1": {"c.2996G>A": 1, "c.12532G>A": 1}}	\N
5934639	5933905	c.13990T>C/c.14458G>T	{"RYR1": {"c.13990T>C": 1, "c.14458G>T": 1}}	\N
5934640	5933905	c.1411C>T/c.12064A>G	{"RYR1": {"c.1411C>T": 1, "c.12064A>G": 1}}	\N
5934641	5933905	c.9268G>A/c.11947C>T	{"RYR1": {"c.9268G>A": 1, "c.11947C>T": 1}}	\N
5934642	5933905	c.7355G>A/c.14639T>C	{"RYR1": {"c.7355G>A": 1, "c.14639T>C": 1}}	\N
5934643	5933905	c.11126C>T/c.12064A>G	{"RYR1": {"c.11126C>T": 1, "c.12064A>G": 1}}	\N
5934644	5933905	c.4763C>T/c.14422_14423delinsAA	{"RYR1": {"c.4763C>T": 1, "c.14422_14423delinsAA": 1}}	\N
5934645	5933905	c.1597C>A/c.14458G>T	{"RYR1": {"c.1597C>A": 1, "c.14458G>T": 1}}	\N
5934646	5933905	c.652G>A/c.6710G>A	{"RYR1": {"c.652G>A": 1, "c.6710G>A": 1}}	\N
5934647	5933905	c.9152G>A/c.11132C>T	{"RYR1": {"c.9152G>A": 1, "c.11132C>T": 1}}	\N
5934648	5933905	c.13990T>C/c.14458G>A	{"RYR1": {"c.13990T>C": 1, "c.14458G>A": 1}}	\N
5934649	5933905	c.12115A>T/c.14678G>A	{"RYR1": {"c.12115A>T": 1, "c.14678G>A": 1}}	\N
5934650	5933905	c.455C>A/c.14424C>A	{"RYR1": {"c.455C>A": 1, "c.14424C>A": 1}}	\N
5934651	5933905	c.1411C>T/c.6710G>A	{"RYR1": {"c.1411C>T": 1, "c.6710G>A": 1}}	\N
5934652	5933905	c.1597C>A/c.1834G>C	{"RYR1": {"c.1597C>A": 1, "c.1834G>C": 1}}	\N
5934653	5933905	c.5024T>C/c.9797T>C	{"RYR1": {"c.5024T>C": 1, "c.9797T>C": 1}}	\N
5934654	5933905	c.1597C>A/c.14458G>A	{"RYR1": {"c.1597C>A": 1, "c.14458G>A": 1}}	\N
5934655	5933905	c.1475G>A/c.13672C>T	{"RYR1": {"c.1475G>A": 1, "c.13672C>T": 1}}	\N
5934656	5933905	c.13673G>A/c.14270G>A	{"RYR1": {"c.13673G>A": 1, "c.14270G>A": 1}}	\N
5934657	5933905	c.8600T>A/c.11953T>C	{"RYR1": {"c.8600T>A": 1, "c.11953T>C": 1}}	\N
5934658	5933905	c.131G>A/c.14639T>C	{"RYR1": {"c.131G>A": 1, "c.14639T>C": 1}}	\N
5934659	5933905	c.9868G>A/c.14270G>A	{"RYR1": {"c.9868G>A": 1, "c.14270G>A": 1}}	\N
5934660	5933905	c.4775C>T/c.5024T>C	{"RYR1": {"c.4775C>T": 1, "c.5024T>C": 1}}	\N
5934661	5933905	c.6635T>A/c.15060G>C	{"RYR1": {"c.6635T>A": 1, "c.15060G>C": 1}}	\N
5934662	5933905	c.7385C>T/c.12121C>T	{"RYR1": {"c.7385C>T": 1, "c.12121C>T": 1}}	\N
5934663	5933905	c.6377G>A/c.13673G>A	{"RYR1": {"c.6377G>A": 1, "c.13673G>A": 1}}	\N
5934664	5933905	c.1598G>A/c.9848G>A	{"RYR1": {"c.1598G>A": 1, "c.9848G>A": 1}}	\N
5934665	5933905	c.7771C>T/c.12383C>T	{"RYR1": {"c.7771C>T": 1, "c.12383C>T": 1}}	\N
5934666	5933905	c.119G>C/c.3172G>A	{"RYR1": {"c.119G>C": 1, "c.3172G>A": 1}}	\N
5934667	5933905	c.8189A>G/c.9652G>A	{"RYR1": {"c.8189A>G": 1, "c.9652G>A": 1}}	\N
5934668	5933905	c.6377G>A/c.13913G>A	{"RYR1": {"c.6377G>A": 1, "c.13913G>A": 1}}	\N
5934669	5933905	c.11416G>A/c.13918A>G	{"RYR1": {"c.11416G>A": 1, "c.13918A>G": 1}}	\N
5934670	5933905	c.1144C>A/c.6635T>A	{"RYR1": {"c.1144C>A": 1, "c.6635T>A": 1}}	\N
5934671	5933905	c.1201C>G/c.7075C>T	{"RYR1": {"c.1201C>G": 1, "c.7075C>T": 1}}	\N
5934672	5933905	c.1422G>T/c.13913G>A	{"RYR1": {"c.1422G>T": 1, "c.13913G>A": 1}}	\N
5934673	5933905	c.6599C>T/c.6671G>A	{"RYR1": {"c.6599C>T": 1, "c.6671G>A": 1}}	\N
5934674	5933905	c.7307G>A/c.13934G>A	{"RYR1": {"c.7307G>A": 1, "c.13934G>A": 1}}	\N
5934675	5933905	c.10043G>A/c.11314C>T	{"RYR1": {"c.10043G>A": 1, "c.11314C>T": 1}}	\N
5934676	5933905	c.5341T>C/c.14818G>A	{"RYR1": {"c.5341T>C": 1, "c.14818G>A": 1}}	\N
5934677	5933905	c.10229C>A/c.10556C>T	{"RYR1": {"c.10229C>A": 1, "c.10556C>T": 1}}	\N
5934678	5933905	c.625G>A/c.12553G>A	{"RYR1": {"c.625G>A": 1, "c.12553G>A": 1}}	\N
5934679	5933905	c.12383C>T/c.14201G>A	{"RYR1": {"c.12383C>T": 1, "c.14201G>A": 1}}	\N
5934680	5933905	c.10043G>A/c.10229C>A	{"RYR1": {"c.10043G>A": 1, "c.10229C>A": 1}}	\N
5934681	5933905	c.488G>A/c.5890C>T	{"RYR1": {"c.488G>A": 1, "c.5890C>T": 1}}	\N
5934682	5933905	c.8654C>G/c.14825G>T	{"RYR1": {"c.8654C>G": 1, "c.14825G>T": 1}}	\N
5934683	5933905	c.6302T>A/c.7199A>G	{"RYR1": {"c.6302T>A": 1, "c.7199A>G": 1}}	\N
5934684	5933905	c.2122G>A/c.14424C>A	{"RYR1": {"c.2122G>A": 1, "c.14424C>A": 1}}	\N
5934685	5933905	c.6037A>C/c.14471T>C	{"RYR1": {"c.6037A>C": 1, "c.14471T>C": 1}}	\N
5934686	5933905	c.6388G>A/c.8654C>G	{"RYR1": {"c.6388G>A": 1, "c.8654C>G": 1}}	\N
5934687	5933905	c.11518G>A/c.11953T>C	{"RYR1": {"c.11518G>A": 1, "c.11953T>C": 1}}	\N
5934688	5933905	c.11958C>G/c.14270G>A	{"RYR1": {"c.11958C>G": 1, "c.14270G>A": 1}}	\N
5934689	5933905	c.8005G>A/c.12355A>T	{"RYR1": {"c.8005G>A": 1, "c.12355A>T": 1}}	\N
5934690	5933905	c.9868G>A/c.12532G>A	{"RYR1": {"c.9868G>A": 1, "c.12532G>A": 1}}	\N
5934691	5933905	c.3418C>T/c.7355G>A	{"RYR1": {"c.3418C>T": 1, "c.7355G>A": 1}}	\N
5934692	5933905	c.8189A>G/c.14509C>G	{"RYR1": {"c.8189A>G": 1, "c.14509C>G": 1}}	\N
5934693	5933905	c.13990T>C/c.14817C>A	{"RYR1": {"c.13990T>C": 1, "c.14817C>A": 1}}	\N
5934694	5933905	c.11416G>A/c.13702C>G	{"RYR1": {"c.11416G>A": 1, "c.13702C>G": 1}}	\N
5934695	5933905	c.212C>A/c.7073T>A	{"RYR1": {"c.212C>A": 1, "c.7073T>A": 1}}	\N
5934696	5933905	c.6544A>T/c.10237A>T	{"RYR1": {"c.6544A>T": 1, "c.10237A>T": 1}}	\N
5934697	5933905	c.13673G>A/c.14002C>T	{"RYR1": {"c.13673G>A": 1, "c.14002C>T": 1}}	\N
5934698	5933905	c.497A>G/c.14968A>G	{"RYR1": {"c.497A>G": 1, "c.14968A>G": 1}}	\N
5934699	5933905	c.493G>A/c.10229C>A	{"RYR1": {"c.493G>A": 1, "c.10229C>A": 1}}	\N
5934700	5933905	c.119G>C/c.12115A>T	{"RYR1": {"c.119G>C": 1, "c.12115A>T": 1}}	\N
5934701	5933905	c.9758T>C/c.12533G>T	{"RYR1": {"c.9758T>C": 1, "c.12533G>T": 1}}	\N
5934702	5933905	c.7085A>G/c.10252A>G	{"RYR1": {"c.7085A>G": 1, "c.10252A>G": 1}}	\N
5934703	5933905	c.6710G>A/c.11813G>A	{"RYR1": {"c.6710G>A": 1, "c.11813G>A": 1}}	\N
5934704	5933905	c.1100G>A/c.14817C>A	{"RYR1": {"c.1100G>A": 1, "c.14817C>A": 1}}	\N
5934705	5933905	c.677T>A/c.3527C>T	{"RYR1": {"c.677T>A": 1, "c.3527C>T": 1}}	\N
5934706	5933905	c.7089C>G/c.7760A>G	{"RYR1": {"c.7089C>G": 1, "c.7760A>G": 1}}	\N
5934707	5933905	c.5132A>G/c.8189A>G	{"RYR1": {"c.5132A>G": 1, "c.8189A>G": 1}}	\N
5934708	5933905	c.2996G>A/c.14581C>T	{"RYR1": {"c.2996G>A": 1, "c.14581C>T": 1}}	\N
5934709	5933905	c.5440A>G/c.7760A>G	{"RYR1": {"c.5440A>G": 1, "c.7760A>G": 1}}	\N
5934710	5933905	c.2654G>A/c.14818G>A	{"RYR1": {"c.2654G>A": 1, "c.14818G>A": 1}}	\N
5934711	5933905	c.212C>A/c.4400A>G	{"RYR1": {"c.212C>A": 1, "c.4400A>G": 1}}	\N
5934712	5933905	c.12115A>T/c.12533G>T	{"RYR1": {"c.12115A>T": 1, "c.12533G>T": 1}}	\N
5934713	5933905	c.528G>T/c.3527C>T	{"RYR1": {"c.528G>T": 1, "c.3527C>T": 1}}	\N
5934714	5933905	c.8054C>T/c.14678G>A	{"RYR1": {"c.8054C>T": 1, "c.14678G>A": 1}}	\N
5934715	5933905	c.8189A>G/c.12064A>G	{"RYR1": {"c.8189A>G": 1, "c.12064A>G": 1}}	\N
5934716	5933905	c.51_53del/c.14581C>T	{"RYR1": {"c.14581C>T": 1, "c.51_53del": 1}}	\N
5934717	5933905	c.9268G>A/c.10237A>T	{"RYR1": {"c.9268G>A": 1, "c.10237A>T": 1}}	\N
5934718	5933905	c.3418C>T/c.7355G>C	{"RYR1": {"c.3418C>T": 1, "c.7355G>C": 1}}	\N
5934719	5933905	c.8188G>C/c.11813G>A	{"RYR1": {"c.8188G>C": 1, "c.11813G>A": 1}}	\N
5934720	5933905	c.251C>T/c.7018T>C	{"RYR1": {"c.251C>T": 1, "c.7018T>C": 1}}	\N
5934721	5933905	c.947G>T/c.11953T>C	{"RYR1": {"c.947G>T": 1, "c.11953T>C": 1}}	\N
5934722	5933905	c.6743G>A/c.8290G>A	{"RYR1": {"c.6743G>A": 1, "c.8290G>A": 1}}	\N
5934723	5933905	c.1100G>T/c.8729C>T	{"RYR1": {"c.1100G>T": 1, "c.8729C>T": 1}}	\N
5934724	5933905	c.493G>A/c.11314C>T	{"RYR1": {"c.493G>A": 1, "c.11314C>T": 1}}	\N
5934725	5933905	c.455C>A/c.14270G>A	{"RYR1": {"c.455C>A": 1, "c.14270G>A": 1}}	\N
5934726	5933905	c.6743G>A/c.12028G>A	{"RYR1": {"c.6743G>A": 1, "c.12028G>A": 1}}	\N
5934727	5933905	c.6635T>A/c.15059G>C	{"RYR1": {"c.6635T>A": 1, "c.15059G>C": 1}}	\N
5934728	5933905	c.652G>A/c.9868G>A	{"RYR1": {"c.652G>A": 1, "c.9868G>A": 1}}	\N
5934729	5933905	c.7099G>A/c.7778G>A	{"RYR1": {"c.7099G>A": 1, "c.7778G>A": 1}}	\N
5934730	5933905	c.7522C>G/c.8518C>T	{"RYR1": {"c.7522C>G": 1, "c.8518C>T": 1}}	\N
5934731	5933905	c.7771C>T/c.7787C>T	{"RYR1": {"c.7771C>T": 1, "c.7787C>T": 1}}	\N
5934732	5933905	c.7777C>G/c.14817C>A	{"RYR1": {"c.7777C>G": 1, "c.14817C>A": 1}}	\N
5934733	5933905	c.11958C>G/c.14002C>T	{"RYR1": {"c.11958C>G": 1, "c.14002C>T": 1}}	\N
5934734	5933905	c.5440A>G/c.14471T>C	{"RYR1": {"c.5440A>G": 1, "c.14471T>C": 1}}	\N
5934735	5933905	c.5441T>A/c.11132C>T	{"RYR1": {"c.5441T>A": 1, "c.11132C>T": 1}}	\N
5934736	5933905	c.3172G>A/c.12532G>A	{"RYR1": {"c.3172G>A": 1, "c.12532G>A": 1}}	\N
5934737	5933905	c.1209C>G/c.9797T>C	{"RYR1": {"c.1209C>G": 1, "c.9797T>C": 1}}	\N
5934738	5933905	c.6548G>A/c.10891G>T	{"RYR1": {"c.6548G>A": 1, "c.10891G>T": 1}}	\N
5934739	5933905	c.9268G>A/c.11120G>T	{"RYR1": {"c.9268G>A": 1, "c.11120G>T": 1}}	\N
5934740	5933905	c.7385C>T/c.14567C>G	{"RYR1": {"c.7385C>T": 1, "c.14567C>G": 1}}	\N
5934741	5933905	c.7085A>G/c.11132C>T	{"RYR1": {"c.7085A>G": 1, "c.11132C>T": 1}}	\N
5934742	5933905	c.533A>C/c.3172G>A	{"RYR1": {"c.533A>C": 1, "c.3172G>A": 1}}	\N
5934743	5933905	c.6743G>A/c.14424C>A	{"RYR1": {"c.6743G>A": 1, "c.14424C>A": 1}}	\N
5934744	5933905	c.6742C>T/c.14825G>T	{"RYR1": {"c.6742C>T": 1, "c.14825G>T": 1}}	\N
5934745	5933905	c.2537C>T/c.14186A>C	{"RYR1": {"c.2537C>T": 1, "c.14186A>C": 1}}	\N
5934746	5933905	c.6671G>A/c.11953T>C	{"RYR1": {"c.6671G>A": 1, "c.11953T>C": 1}}	\N
5934747	5933905	c.1100G>A/c.9797T>C	{"RYR1": {"c.1100G>A": 1, "c.9797T>C": 1}}	\N
5934748	5933905	c.10556C>T/c.10891G>T	{"RYR1": {"c.10556C>T": 1, "c.10891G>T": 1}}	\N
5934749	5933905	c.178G>T/c.2122G>A	{"RYR1": {"c.178G>T": 1, "c.2122G>A": 1}}	\N
5934750	5933905	c.7210G>A/c.10237A>T	{"RYR1": {"c.7210G>A": 1, "c.10237A>T": 1}}	\N
5934751	5933905	c.1209C>G/c.6302T>A	{"RYR1": {"c.1209C>G": 1, "c.6302T>A": 1}}	\N
5934752	5933905	c.9850T>A/c.11953T>C	{"RYR1": {"c.9850T>A": 1, "c.11953T>C": 1}}	\N
5934753	5933905	c.6710G>A/c.12115A>T	{"RYR1": {"c.6710G>A": 1, "c.12115A>T": 1}}	\N
5934754	5933905	c.7032G>C/c.14879T>A	{"RYR1": {"c.7032G>C": 1, "c.14879T>A": 1}}	\N
5934755	5933905	c.641C>T/c.4775C>T	{"RYR1": {"c.641C>T": 1, "c.4775C>T": 1}}	\N
5934756	5933905	c.1100G>A/c.7778G>A	{"RYR1": {"c.1100G>A": 1, "c.7778G>A": 1}}	\N
5934757	5933905	c.11120G>T/c.14818G>A	{"RYR1": {"c.11120G>T": 1, "c.14818G>A": 1}}	\N
5934758	5933905	c.7385C>T/c.9797T>C	{"RYR1": {"c.7385C>T": 1, "c.9797T>C": 1}}	\N
5934759	5933905	c.6671G>A/c.7487C>T	{"RYR1": {"c.6671G>A": 1, "c.7487C>T": 1}}	\N
5934760	5933905	c.119G>C/c.7317G>C	{"RYR1": {"c.119G>C": 1, "c.7317G>C": 1}}	\N
5934761	5933905	c.251C>T/c.7085A>G	{"RYR1": {"c.251C>T": 1, "c.7085A>G": 1}}	\N
5934762	5933905	c.5033A>G/c.5033A>G	{"RYR1": {"c.5033A>G": 2}}	\N
5934763	5933905	c.8654C>G/c.13918A>G	{"RYR1": {"c.8654C>G": 1, "c.13918A>G": 1}}	\N
5934764	5933905	c.8600T>A/c.9649T>C	{"RYR1": {"c.8600T>A": 1, "c.9649T>C": 1}}	\N
5934765	5933905	c.3667G>A/c.6377G>A	{"RYR1": {"c.3667G>A": 1, "c.6377G>A": 1}}	\N
5934766	5933905	c.652G>A/c.14449A>T	{"RYR1": {"c.652G>A": 1, "c.14449A>T": 1}}	\N
5934767	5933905	c.6548G>A/c.8729C>T	{"RYR1": {"c.6548G>A": 1, "c.8729C>T": 1}}	\N
5934768	5933905	c.119G>C/c.4747C>T	{"RYR1": {"c.119G>C": 1, "c.4747C>T": 1}}	\N
5934769	5933905	c.6635T>A/c.13990T>C	{"RYR1": {"c.6635T>A": 1, "c.13990T>C": 1}}	\N
5934770	5933905	c.479A>G/c.652G>A	{"RYR1": {"c.479A>G": 1, "c.652G>A": 1}}	\N
5934771	5933905	c.8189A>G/c.9868G>A	{"RYR1": {"c.8189A>G": 1, "c.9868G>A": 1}}	\N
5934772	5933905	c.6635T>A/c.8005G>A	{"RYR1": {"c.6635T>A": 1, "c.8005G>A": 1}}	\N
5934773	5933905	c.13934G>A/c.13990T>C	{"RYR1": {"c.13934G>A": 1, "c.13990T>C": 1}}	\N
5934774	5933905	c.992_994dup/c.2924G>A	{"RYR1": {"c.2924G>A": 1, "c.992_994dup": 1}}	\N
5934775	5933905	c.6742C>T/c.13702C>G	{"RYR1": {"c.6742C>T": 1, "c.13702C>G": 1}}	\N
5934776	5933905	c.3166G>A/c.8290G>A	{"RYR1": {"c.3166G>A": 1, "c.8290G>A": 1}}	\N
5934777	5933905	c.2122G>A/c.12028G>A	{"RYR1": {"c.2122G>A": 1, "c.12028G>A": 1}}	\N
5934778	5933905	c.7018T>C/c.10252A>G	{"RYR1": {"c.7018T>C": 1, "c.10252A>G": 1}}	\N
5934779	5933905	c.7099G>A/c.14782A>G	{"RYR1": {"c.7099G>A": 1, "c.14782A>G": 1}}	\N
5934780	5933905	c.7097C>G/c.7778G>A	{"RYR1": {"c.7097C>G": 1, "c.7778G>A": 1}}	\N
5934781	5933905	c.152C>A/c.13918A>G	{"RYR1": {"c.152C>A": 1, "c.13918A>G": 1}}	\N
5934782	5933905	c.5132A>G/c.12242C>T	{"RYR1": {"c.5132A>G": 1, "c.12242C>T": 1}}	\N
5934783	5933905	c.7073T>A/c.8638G>A	{"RYR1": {"c.7073T>A": 1, "c.8638G>A": 1}}	\N
5934784	5933905	c.1553T>C/c.14693T>C	{"RYR1": {"c.1553T>C": 1, "c.14693T>C": 1}}	\N
5934785	5933905	c.528G>T/c.14186A>C	{"RYR1": {"c.528G>T": 1, "c.14186A>C": 1}}	\N
5934786	5933905	c.1553T>C/c.14458G>T	{"RYR1": {"c.1553T>C": 1, "c.14458G>T": 1}}	\N
5934787	5933905	c.1144C>A/c.11953T>C	{"RYR1": {"c.1144C>A": 1, "c.11953T>C": 1}}	\N
5934788	5933905	c.652G>A/c.1460T>C	{"RYR1": {"c.652G>A": 1, "c.1460T>C": 1}}	\N
5934789	5933905	c.251C>T/c.10556C>T	{"RYR1": {"c.251C>T": 1, "c.10556C>T": 1}}	\N
5934790	5933905	c.11813G>A/c.14387A>G	{"RYR1": {"c.11813G>A": 1, "c.14387A>G": 1}}	\N
5934791	5933905	c.6548G>A/c.14813T>C	{"RYR1": {"c.6548G>A": 1, "c.14813T>C": 1}}	\N
5934792	5933905	c.8290G>A/c.14817C>A	{"RYR1": {"c.8290G>A": 1, "c.14817C>A": 1}}	\N
5934793	5933905	c.9797T>C/c.11958C>G	{"RYR1": {"c.9797T>C": 1, "c.11958C>G": 1}}	\N
5934794	5933905	c.9635A>G/c.9797T>C	{"RYR1": {"c.9635A>G": 1, "c.9797T>C": 1}}	\N
5934795	5933905	c.533A>C/c.14364+1G>T	{"RYR1": {"c.533A>C": 1, "c.14364+1G>T": 1}}	\N
5934796	5933905	c.7355G>C/c.15060G>C	{"RYR1": {"c.7355G>C": 1, "c.15060G>C": 1}}	\N
5934797	5933905	c.212C>A/c.11947C>T	{"RYR1": {"c.212C>A": 1, "c.11947C>T": 1}}	\N
5934798	5933905	c.467G>A/c.14818G>A	{"RYR1": {"c.467G>A": 1, "c.14818G>A": 1}}	\N
5934799	5933905	c.6304G>C/c.14879T>A	{"RYR1": {"c.6304G>C": 1, "c.14879T>A": 1}}	\N
5934800	5933905	c.1201C>A/c.7075C>T	{"RYR1": {"c.1201C>A": 1, "c.7075C>T": 1}}	\N
5934801	5933905	c.13918A>G/c.13990T>C	{"RYR1": {"c.13918A>G": 1, "c.13990T>C": 1}}	\N
5934802	5933905	c.51_53del/c.13505A>G	{"RYR1": {"c.13505A>G": 1, "c.51_53del": 1}}	\N
5934803	5933905	c.9356G>A/c.10237A>T	{"RYR1": {"c.9356G>A": 1, "c.10237A>T": 1}}	\N
5934804	5933905	c.8005G>A/c.12848A>T	{"RYR1": {"c.8005G>A": 1, "c.12848A>T": 1}}	\N
5934805	5933905	c.9652G>A/c.14680G>A	{"RYR1": {"c.9652G>A": 1, "c.14680G>A": 1}}	\N
5934806	5933905	c.2050G>C/c.13913G>A	{"RYR1": {"c.2050G>C": 1, "c.13913G>A": 1}}	\N
5934807	5933905	c.3667G>A/c.14639T>C	{"RYR1": {"c.3667G>A": 1, "c.14639T>C": 1}}	\N
5934808	5933905	c.946C>T/c.14817C>A	{"RYR1": {"c.946C>T": 1, "c.14817C>A": 1}}	\N
5934809	5933905	c.6377G>A/c.8054C>T	{"RYR1": {"c.6377G>A": 1, "c.8054C>T": 1}}	\N
5934810	5933905	c.3166G>A/c.5033A>G	{"RYR1": {"c.3166G>A": 1, "c.5033A>G": 1}}	\N
5934811	5933905	c.6847A>C/c.14051T>C	{"RYR1": {"c.6847A>C": 1, "c.14051T>C": 1}}	\N
5934812	5933905	c.467G>A/c.11120G>T	{"RYR1": {"c.467G>A": 1, "c.11120G>T": 1}}	\N
5934813	5933905	c.6377G>A/c.7528T>C	{"RYR1": {"c.6377G>A": 1, "c.7528T>C": 1}}	\N
5934814	5933905	c.8198G>A/c.9868G>A	{"RYR1": {"c.8198G>A": 1, "c.9868G>A": 1}}	\N
5934815	5933905	c.8189A>G/c.9676G>C	{"RYR1": {"c.8189A>G": 1, "c.9676G>C": 1}}	\N
5934816	5933905	c.1209C>G/c.14567C>G	{"RYR1": {"c.1209C>G": 1, "c.14567C>G": 1}}	\N
5934817	5933905	c.178G>T/c.7760A>G	{"RYR1": {"c.178G>T": 1, "c.7760A>G": 1}}	\N
5934818	5933905	c.13990T>C/c.14782A>G	{"RYR1": {"c.13990T>C": 1, "c.14782A>G": 1}}	\N
5934819	5933905	c.3127C>T/c.11086G>C	{"RYR1": {"c.3127C>T": 1, "c.11086G>C": 1}}	\N
5934820	5933905	c.7355G>A/c.12355A>T	{"RYR1": {"c.7355G>A": 1, "c.12355A>T": 1}}	\N
5934821	5933905	c.7787C>T/c.11126C>T	{"RYR1": {"c.7787C>T": 1, "c.11126C>T": 1}}	\N
5934822	5933905	c.119G>C/c.14197T>G	{"RYR1": {"c.119G>C": 1, "c.14197T>G": 1}}	\N
5934823	5933905	c.7487C>T/c.14126C>T	{"RYR1": {"c.7487C>T": 1, "c.14126C>T": 1}}	\N
5934824	5933905	c.1201C>G/c.7292A>T	{"RYR1": {"c.1201C>G": 1, "c.7292A>T": 1}}	\N
5934825	5933905	c.7089C>G/c.12355A>T	{"RYR1": {"c.7089C>G": 1, "c.12355A>T": 1}}	\N
5934826	5933905	c.2050G>C/c.7487C>T	{"RYR1": {"c.2050G>C": 1, "c.7487C>T": 1}}	\N
5934827	5933905	c.9676G>C/c.9868G>A	{"RYR1": {"c.9676G>C": 1, "c.9868G>A": 1}}	\N
5934828	5933905	c.1553T>C/c.14458G>A	{"RYR1": {"c.1553T>C": 1, "c.14458G>A": 1}}	\N
5934829	5933905	c.2537C>T/c.3527C>T	{"RYR1": {"c.2537C>T": 1, "c.3527C>T": 1}}	\N
5934830	5933905	c.6599C>T/c.14693T>C	{"RYR1": {"c.6599C>T": 1, "c.14693T>C": 1}}	\N
5934831	5933905	c.212C>A/c.12553G>A	{"RYR1": {"c.212C>A": 1, "c.12553G>A": 1}}	\N
5934832	5933905	c.12848A>T/c.14678G>A	{"RYR1": {"c.12848A>T": 1, "c.14678G>A": 1}}	\N
5934833	5933905	c.5890C>T/c.9797T>C	{"RYR1": {"c.5890C>T": 1, "c.9797T>C": 1}}	\N
5934834	5933905	c.1598G>A/c.9499C>T	{"RYR1": {"c.1598G>A": 1, "c.9499C>T": 1}}	\N
5934835	5933905	c.3418C>T/c.8600T>A	{"RYR1": {"c.3418C>T": 1, "c.8600T>A": 1}}	\N
5934836	5933905	c.7018T>C/c.9635A>G	{"RYR1": {"c.7018T>C": 1, "c.9635A>G": 1}}	\N
5934837	5933905	c.947G>T/c.7112A>G	{"RYR1": {"c.947G>T": 1, "c.7112A>G": 1}}	\N
5934838	5933905	c.946C>T/c.9797T>C	{"RYR1": {"c.946C>T": 1, "c.9797T>C": 1}}	\N
5934839	5933905	c.6548G>A/c.11132C>T	{"RYR1": {"c.6548G>A": 1, "c.11132C>T": 1}}	\N
5934840	5933905	c.1598G>A/c.13673G>A	{"RYR1": {"c.1598G>A": 1, "c.13673G>A": 1}}	\N
5934841	5933905	c.12413T>C/c.14680G>A	{"RYR1": {"c.12413T>C": 1, "c.14680G>A": 1}}	\N
5934842	5933905	c.1411C>T/c.2924G>A	{"RYR1": {"c.1411C>T": 1, "c.2924G>A": 1}}	\N
5934843	5933905	c.7522C>G/c.14201G>A	{"RYR1": {"c.7522C>G": 1, "c.14201G>A": 1}}	\N
5934844	5933905	c.251C>T/c.14524G>A	{"RYR1": {"c.251C>T": 1, "c.14524G>A": 1}}	\N
5934845	5933905	c.6544A>T/c.14818G>A	{"RYR1": {"c.6544A>T": 1, "c.14818G>A": 1}}	\N
5934846	5933905	c.7778G>A/c.9356G>A	{"RYR1": {"c.7778G>A": 1, "c.9356G>A": 1}}	\N
5934847	5933905	c.7760A>G/c.13505A>G	{"RYR1": {"c.7760A>G": 1, "c.13505A>G": 1}}	\N
5934848	5933905	c.5186T>G/c.14825G>T	{"RYR1": {"c.5186T>G": 1, "c.14825G>T": 1}}	\N
5934849	5933905	c.2924G>A/c.6671G>A	{"RYR1": {"c.2924G>A": 1, "c.6671G>A": 1}}	\N
5934850	5933905	c.7210G>A/c.12413T>C	{"RYR1": {"c.7210G>A": 1, "c.12413T>C": 1}}	\N
5934851	5933905	c.1475G>A/c.11748T>G	{"RYR1": {"c.1475G>A": 1, "c.11748T>G": 1}}	\N
5934852	5933905	c.131G>A/c.13994_13995delTCinsCT	{"RYR1": {"c.131G>A": 1, "c.13994_13995delTCinsCT": 1}}	\N
5934853	5933905	c.1422G>T/c.7487C>T	{"RYR1": {"c.1422G>T": 1, "c.7487C>T": 1}}	\N
5934854	5933905	c.6037A>C/c.14825G>T	{"RYR1": {"c.6037A>C": 1, "c.14825G>T": 1}}	\N
5934855	5933905	c.14582G>A/c.14813T>C	{"RYR1": {"c.14582G>A": 1, "c.14813T>C": 1}}	\N
5934856	5933905	c.526G>A/c.1475G>A	{"RYR1": {"c.526G>A": 1, "c.1475G>A": 1}}	\N
5934857	5933905	c.9356G>A/c.14818G>A	{"RYR1": {"c.9356G>A": 1, "c.14818G>A": 1}}	\N
5934858	5933905	c.2996G>A/c.5440A>G	{"RYR1": {"c.2996G>A": 1, "c.5440A>G": 1}}	\N
5934859	5933905	c.190T>C/c.12064A>G	{"RYR1": {"c.190T>C": 1, "c.12064A>G": 1}}	\N
5934860	5933905	c.7210G>A/c.14422_14423delinsAA	{"RYR1": {"c.7210G>A": 1, "c.14422_14423delinsAA": 1}}	\N
5934861	5933905	c.652G>A/c.9268G>A	{"RYR1": {"c.652G>A": 1, "c.9268G>A": 1}}	\N
5934862	5933905	c.6388G>A/c.12848A>T	{"RYR1": {"c.6388G>A": 1, "c.12848A>T": 1}}	\N
5934863	5933905	c.178G>A/c.14639T>C	{"RYR1": {"c.178G>A": 1, "c.14639T>C": 1}}	\N
5934864	5933905	c.6544A>T/c.6548G>A	{"RYR1": {"c.6544A>T": 1, "c.6548G>A": 1}}	\N
5934865	5933905	c.2996G>A/c.14813T>C	{"RYR1": {"c.2996G>A": 1, "c.14813T>C": 1}}	\N
5934866	5933905	c.11813G>A/c.13760C>T	{"RYR1": {"c.11813G>A": 1, "c.13760C>T": 1}}	\N
5934867	5933905	c.9356G>A/c.14458G>A	{"RYR1": {"c.9356G>A": 1, "c.14458G>A": 1}}	\N
5934868	5933905	c.2537C>T/c.8926C>T	{"RYR1": {"c.2537C>T": 1, "c.8926C>T": 1}}	\N
5934869	5933905	c.190T>C/c.14509C>G	{"RYR1": {"c.190T>C": 1, "c.14509C>G": 1}}	\N
5934870	5933905	c.251C>T/c.9652G>A	{"RYR1": {"c.251C>T": 1, "c.9652G>A": 1}}	\N
5934871	5933905	c.946C>T/c.7778G>A	{"RYR1": {"c.946C>T": 1, "c.7778G>A": 1}}	\N
5934872	5933905	c.5441T>A/c.8729C>T	{"RYR1": {"c.5441T>A": 1, "c.8729C>T": 1}}	\N
5934873	5933905	c.5024T>C/c.10891G>T	{"RYR1": {"c.5024T>C": 1, "c.10891G>T": 1}}	\N
5934874	5933905	c.8198G>A/c.11723A>T	{"RYR1": {"c.8198G>A": 1, "c.11723A>T": 1}}	\N
5934875	5933905	c.5033A>G/c.14678G>A	{"RYR1": {"c.5033A>G": 1, "c.14678G>A": 1}}	\N
5934876	5933905	c.8290G>A/c.14782A>G	{"RYR1": {"c.8290G>A": 1, "c.14782A>G": 1}}	\N
5934877	5933905	c.493G>A/c.9635A>G	{"RYR1": {"c.493G>A": 1, "c.9635A>G": 1}}	\N
5934878	5933905	c.7032G>C/c.11416G>A	{"RYR1": {"c.7032G>C": 1, "c.11416G>A": 1}}	\N
5934879	5933905	c.5890C>T/c.14782A>G	{"RYR1": {"c.5890C>T": 1, "c.14782A>G": 1}}	\N
5934880	5933905	c.455C>A/c.493G>A	{"RYR1": {"c.455C>A": 1, "c.493G>A": 1}}	\N
5934881	5933905	c.12242C>T/c.14051T>C	{"RYR1": {"c.12242C>T": 1, "c.14051T>C": 1}}	\N
5934882	5933905	c.9356G>A/c.14458G>T	{"RYR1": {"c.9356G>A": 1, "c.14458G>T": 1}}	\N
5934883	5933905	c.7018T>C/c.14813T>C	{"RYR1": {"c.7018T>C": 1, "c.14813T>C": 1}}	\N
5934884	5933905	c.7771C>G/c.9649T>C	{"RYR1": {"c.7771C>G": 1, "c.9649T>C": 1}}	\N
5934885	5933905	c.131G>A/c.6377G>A	{"RYR1": {"c.131G>A": 1, "c.6377G>A": 1}}	\N
5934886	5933905	c.455C>A/c.3166G>A	{"RYR1": {"c.455C>A": 1, "c.3166G>A": 1}}	\N
5934887	5933905	c.467G>A/c.1459C>G	{"RYR1": {"c.467G>A": 1, "c.1459C>G": 1}}	\N
5934888	5933905	c.2537C>T/c.5890C>T	{"RYR1": {"c.2537C>T": 1, "c.5890C>T": 1}}	\N
5934889	5933905	c.3667G>A/c.6304G>C	{"RYR1": {"c.3667G>A": 1, "c.6304G>C": 1}}	\N
5934890	5933905	c.7089C>G/c.10042C>T	{"RYR1": {"c.7089C>G": 1, "c.10042C>T": 1}}	\N
5934891	5933905	c.6635T>A/c.9499C>T	{"RYR1": {"c.6635T>A": 1, "c.9499C>T": 1}}	\N
5934892	5933905	c.1411C>T/c.9676G>C	{"RYR1": {"c.1411C>T": 1, "c.9676G>C": 1}}	\N
5934893	5933905	c.251C>T/c.9676G>C	{"RYR1": {"c.251C>T": 1, "c.9676G>C": 1}}	\N
5934894	5933905	c.496G>A/c.11958C>G	{"RYR1": {"c.496G>A": 1, "c.11958C>G": 1}}	\N
5934895	5933905	c.6742C>T/c.8518C>T	{"RYR1": {"c.6742C>T": 1, "c.8518C>T": 1}}	\N
5934896	5933905	c.10042C>T/c.10556C>T	{"RYR1": {"c.10042C>T": 1, "c.10556C>T": 1}}	\N
5934897	5933905	c.7032G>C/c.14051T>C	{"RYR1": {"c.7032G>C": 1, "c.14051T>C": 1}}	\N
5934898	5933905	c.2050G>C/c.11953T>C	{"RYR1": {"c.2050G>C": 1, "c.11953T>C": 1}}	\N
5934899	5933905	c.1475G>A/c.8600T>A	{"RYR1": {"c.1475G>A": 1, "c.8600T>A": 1}}	\N
5934900	5933905	c.14051T>C/c.14968A>G	{"RYR1": {"c.14051T>C": 1, "c.14968A>G": 1}}	\N
5934901	5933905	c.641C>T/c.4763C>T	{"RYR1": {"c.641C>T": 1, "c.4763C>T": 1}}	\N
5934902	5933905	c.4747C>T/c.5341T>C	{"RYR1": {"c.4747C>T": 1, "c.5341T>C": 1}}	\N
5934903	5933905	c.7771C>T/c.11947C>T	{"RYR1": {"c.7771C>T": 1, "c.11947C>T": 1}}	\N
5934904	5933905	c.3527C>T/c.8638G>A	{"RYR1": {"c.3527C>T": 1, "c.8638G>A": 1}}	\N
5934905	5933905	c.641C>T/c.4400A>G	{"RYR1": {"c.641C>T": 1, "c.4400A>G": 1}}	\N
5934906	5933905	c.131G>A/c.10042C>T	{"RYR1": {"c.131G>A": 1, "c.10042C>T": 1}}	\N
5934907	5933905	c.7097C>G/c.14782A>G	{"RYR1": {"c.7097C>G": 1, "c.14782A>G": 1}}	\N
5934908	5933905	c.7355G>A/c.8005G>A	{"RYR1": {"c.7355G>A": 1, "c.8005G>A": 1}}	\N
5934909	5933905	c.7355G>C/c.8005G>A	{"RYR1": {"c.7355G>C": 1, "c.8005G>A": 1}}	\N
5934910	5933905	c.8926C>T/c.9797T>C	{"RYR1": {"c.8926C>T": 1, "c.9797T>C": 1}}	\N
5934911	5933905	c.9676G>C/c.14509C>G	{"RYR1": {"c.9676G>C": 1, "c.14509C>G": 1}}	\N
5934912	5933905	c.625G>A/c.1100G>T	{"RYR1": {"c.625G>A": 1, "c.1100G>T": 1}}	\N
5934913	5933905	c.6640G>A/c.11813G>A	{"RYR1": {"c.6640G>A": 1, "c.11813G>A": 1}}	\N
5934914	5933905	c.1422G>T/c.14458G>A	{"RYR1": {"c.1422G>T": 1, "c.14458G>A": 1}}	\N
5934915	5933905	c.1597C>A/c.7032G>C	{"RYR1": {"c.1597C>A": 1, "c.7032G>C": 1}}	\N
5934916	5933905	c.2122G>A/c.8290G>A	{"RYR1": {"c.2122G>A": 1, "c.8290G>A": 1}}	\N
5934917	5933905	c.11132C>T/c.14680G>A	{"RYR1": {"c.11132C>T": 1, "c.14680G>A": 1}}	\N
5934918	5933905	c.14639T>C/c.14818G>A	{"RYR1": {"c.14639T>C": 1, "c.14818G>A": 1}}	\N
5934919	5933905	c.12553G>A/c.14270G>A	{"RYR1": {"c.12553G>A": 1, "c.14270G>A": 1}}	\N
5934920	5933905	c.178G>T/c.13994_13995delTCinsCT	{"RYR1": {"c.178G>T": 1, "c.13994_13995delTCinsCT": 1}}	\N
5934921	5933905	c.212C>A/c.7522C>G	{"RYR1": {"c.212C>A": 1, "c.7522C>G": 1}}	\N
5934922	5933905	c.14471T>C/c.14567C>G	{"RYR1": {"c.14471T>C": 1, "c.14567C>G": 1}}	\N
5934923	5933905	c.14458G>A/c.14581C>T	{"RYR1": {"c.14458G>A": 1, "c.14581C>T": 1}}	\N
5934924	5933905	c.14387A>G/c.14825G>T	{"RYR1": {"c.14387A>G": 1, "c.14825G>T": 1}}	\N
5934925	5933905	c.528G>T/c.5186T>G	{"RYR1": {"c.528G>T": 1, "c.5186T>G": 1}}	\N
5934926	5933905	c.1553T>C/c.3667G>A	{"RYR1": {"c.1553T>C": 1, "c.3667G>A": 1}}	\N
5934927	5933905	c.251C>T/c.14126C>T	{"RYR1": {"c.251C>T": 1, "c.14126C>T": 1}}	\N
5934928	5933905	c.1453A>G/c.7760A>G	{"RYR1": {"c.1453A>G": 1, "c.7760A>G": 1}}	\N
5934929	5933905	c.212C>A/c.7307G>A	{"RYR1": {"c.212C>A": 1, "c.7307G>A": 1}}	\N
5934930	5933905	c.251C>T/c.9850T>A	{"RYR1": {"c.251C>T": 1, "c.9850T>A": 1}}	\N
5934931	5933905	c.625G>A/c.1100G>A	{"RYR1": {"c.625G>A": 1, "c.1100G>A": 1}}	\N
5934932	5933905	c.7307G>A/c.11813G>A	{"RYR1": {"c.7307G>A": 1, "c.11813G>A": 1}}	\N
5934933	5933905	c.8290G>A/c.12553G>A	{"RYR1": {"c.8290G>A": 1, "c.12553G>A": 1}}	\N
5934934	5933905	c.641C>T/c.11947C>T	{"RYR1": {"c.641C>T": 1, "c.11947C>T": 1}}	\N
5934935	5933905	c.119G>C/c.9499C>T	{"RYR1": {"c.119G>C": 1, "c.9499C>T": 1}}	\N
5934936	5933905	c.1475G>A/c.11958C>G	{"RYR1": {"c.1475G>A": 1, "c.11958C>G": 1}}	\N
5934937	5933905	c.3656A>C/c.6710G>A	{"RYR1": {"c.3656A>C": 1, "c.6710G>A": 1}}	\N
5934938	5933905	c.493G>A/c.14270G>A	{"RYR1": {"c.493G>A": 1, "c.14270G>A": 1}}	\N
5934939	5933905	c.7210G>A/c.14458G>A	{"RYR1": {"c.7210G>A": 1, "c.14458G>A": 1}}	\N
5934940	5933905	c.6640G>A/c.7292A>T	{"RYR1": {"c.6640G>A": 1, "c.7292A>T": 1}}	\N
5934941	5933905	c.12553G>A/c.14581C>T	{"RYR1": {"c.12553G>A": 1, "c.14581C>T": 1}}	\N
5934942	5933905	c.4747C>T/c.12533G>T	{"RYR1": {"c.4747C>T": 1, "c.12533G>T": 1}}	\N
5934943	5933905	c.1553T>C/c.7777C>G	{"RYR1": {"c.1553T>C": 1, "c.7777C>G": 1}}	\N
5934944	5933905	c.3418C>T/c.6635T>A	{"RYR1": {"c.3418C>T": 1, "c.6635T>A": 1}}	\N
5934945	5933905	c.6302T>A/c.7777C>G	{"RYR1": {"c.6302T>A": 1, "c.7777C>G": 1}}	\N
5934946	5933905	c.533A>C/c.12115A>T	{"RYR1": {"c.533A>C": 1, "c.12115A>T": 1}}	\N
5934947	5933905	c.1201C>A/c.7292A>T	{"RYR1": {"c.1201C>A": 1, "c.7292A>T": 1}}	\N
5934948	5933905	c.467G>A/c.1411C>T	{"RYR1": {"c.467G>A": 1, "c.1411C>T": 1}}	\N
5934949	5933905	c.1024G>A/c.11086G>C	{"RYR1": {"c.1024G>A": 1, "c.11086G>C": 1}}	\N
5934950	5933905	c.1422G>T/c.14458G>T	{"RYR1": {"c.1422G>T": 1, "c.14458G>T": 1}}	\N
5934951	5933905	c.2654G>A/c.3667G>A	{"RYR1": {"c.2654G>A": 1, "c.3667G>A": 1}}	\N
5934952	5933905	c.5341T>C/c.7199A>G	{"RYR1": {"c.5341T>C": 1, "c.7199A>G": 1}}	\N
5934953	5933905	c.8290G>A/c.11947C>T	{"RYR1": {"c.8290G>A": 1, "c.11947C>T": 1}}	\N
5934954	5933905	c.152C>A/c.14879T>A	{"RYR1": {"c.152C>A": 1, "c.14879T>A": 1}}	\N
5934955	5933905	c.9676G>C/c.12064A>G	{"RYR1": {"c.9676G>C": 1, "c.12064A>G": 1}}	\N
5934956	5933905	c.14458G>A/c.14678G>A	{"RYR1": {"c.14458G>A": 1, "c.14678G>A": 1}}	\N
5934957	5933905	c.7032G>C/c.10043G>A	{"RYR1": {"c.7032G>C": 1, "c.10043G>A": 1}}	\N
5934958	5933905	c.2050G>C/c.6548G>A	{"RYR1": {"c.2050G>C": 1, "c.6548G>A": 1}}	\N
5934959	5933905	c.190T>C/c.9868G>A	{"RYR1": {"c.190T>C": 1, "c.9868G>A": 1}}	\N
5934960	5933905	c.625G>A/c.7307G>A	{"RYR1": {"c.625G>A": 1, "c.7307G>A": 1}}	\N
5934961	5933905	c.526G>A/c.12121C>T	{"RYR1": {"c.526G>A": 1, "c.12121C>T": 1}}	\N
5934962	5933905	c.7112A>G/c.9649T>C	{"RYR1": {"c.7112A>G": 1, "c.9649T>C": 1}}	\N
5934963	5933905	c.10237A>T/c.14818G>A	{"RYR1": {"c.10237A>T": 1, "c.14818G>A": 1}}	\N
5934964	5933905	c.8600T>A/c.9758T>C	{"RYR1": {"c.8600T>A": 1, "c.9758T>C": 1}}	\N
5934965	5933905	c.1422G>T/c.10237A>T	{"RYR1": {"c.1422G>T": 1, "c.10237A>T": 1}}	\N
5934966	5933905	c.14270G>A/c.14422_14423delinsAA	{"RYR1": {"c.14270G>A": 1, "c.14422_14423delinsAA": 1}}	\N
5934967	5933905	c.11120G>T/c.14458G>T	{"RYR1": {"c.11120G>T": 1, "c.14458G>T": 1}}	\N
5934968	5933905	c.14567C>G/c.14813T>C	{"RYR1": {"c.14567C>G": 1, "c.14813T>C": 1}}	\N
5934969	5933905	c.2924G>A/c.14693T>C	{"RYR1": {"c.2924G>A": 1, "c.14693T>C": 1}}	\N
5934970	5933905	c.497A>G/c.6640G>A	{"RYR1": {"c.497A>G": 1, "c.6640G>A": 1}}	\N
5934971	5933905	c.5132A>G/c.11518G>A	{"RYR1": {"c.5132A>G": 1, "c.11518G>A": 1}}	\N
5934972	5933905	c.7075C>T/c.14270G>A	{"RYR1": {"c.7075C>T": 1, "c.14270G>A": 1}}	\N
5934973	5933905	c.533A>C/c.9152G>A	{"RYR1": {"c.533A>C": 1, "c.9152G>A": 1}}	\N
5934974	5933905	c.9152G>A/c.14567C>G	{"RYR1": {"c.9152G>A": 1, "c.14567C>G": 1}}	\N
5934975	5933905	c.7778G>A/c.8600T>A	{"RYR1": {"c.7778G>A": 1, "c.8600T>A": 1}}	\N
5934976	5933905	c.11120G>T/c.14458G>A	{"RYR1": {"c.11120G>T": 1, "c.14458G>A": 1}}	\N
5934977	5933905	c.9152G>A/c.10252A>G	{"RYR1": {"c.9152G>A": 1, "c.10252A>G": 1}}	\N
5934978	5933905	c.10042C>T/c.14126C>T	{"RYR1": {"c.10042C>T": 1, "c.14126C>T": 1}}	\N
5934979	5933905	c.10042C>T/c.14524G>A	{"RYR1": {"c.10042C>T": 1, "c.14524G>A": 1}}	\N
5934980	5933905	c.493G>A/c.3166G>A	{"RYR1": {"c.493G>A": 1, "c.3166G>A": 1}}	\N
5934981	5933905	c.677T>A/c.14968A>G	{"RYR1": {"c.677T>A": 1, "c.14968A>G": 1}}	\N
5934982	5933905	c.496G>A/c.7355G>C	{"RYR1": {"c.496G>A": 1, "c.7355G>C": 1}}	\N
5934983	5933905	c.496G>A/c.7355G>A	{"RYR1": {"c.496G>A": 1, "c.7355G>A": 1}}	\N
5934984	5933905	c.1422G>T/c.14422_14423delinsAA	{"RYR1": {"c.1422G>T": 1, "c.14422_14423delinsAA": 1}}	\N
5934985	5933905	c.10043G>A/c.14270G>A	{"RYR1": {"c.10043G>A": 1, "c.14270G>A": 1}}	\N
5934986	5933905	c.1422G>T/c.7528T>C	{"RYR1": {"c.1422G>T": 1, "c.7528T>C": 1}}	\N
5934987	5933905	c.7771C>G/c.7787C>T	{"RYR1": {"c.7771C>G": 1, "c.7787C>T": 1}}	\N
5934988	5933905	c.14270G>A/c.14458G>T	{"RYR1": {"c.14270G>A": 1, "c.14458G>T": 1}}	\N
5934989	5933905	c.1144C>A/c.7355G>A	{"RYR1": {"c.1144C>A": 1, "c.7355G>A": 1}}	\N
5934990	5933905	c.1144C>A/c.7355G>C	{"RYR1": {"c.1144C>A": 1, "c.7355G>C": 1}}	\N
5934991	5933905	c.178G>A/c.6304G>C	{"RYR1": {"c.178G>A": 1, "c.6304G>C": 1}}	\N
5934992	5933905	c.625G>A/c.1834G>C	{"RYR1": {"c.625G>A": 1, "c.1834G>C": 1}}	\N
5934993	5933905	c.641C>T/c.7073T>A	{"RYR1": {"c.641C>T": 1, "c.7073T>A": 1}}	\N
5934994	5933905	c.5024T>C/c.11132C>T	{"RYR1": {"c.5024T>C": 1, "c.11132C>T": 1}}	\N
5934995	5933905	c.251C>T/c.1201C>A	{"RYR1": {"c.251C>T": 1, "c.1201C>A": 1}}	\N
5934996	5933905	c.488G>A/c.13702C>G	{"RYR1": {"c.488G>A": 1, "c.13702C>G": 1}}	\N
5934997	5933905	c.1475G>A/c.9758T>C	{"RYR1": {"c.1475G>A": 1, "c.9758T>C": 1}}	\N
5934998	5933905	c.251C>T/c.1201C>G	{"RYR1": {"c.251C>T": 1, "c.1201C>G": 1}}	\N
5934999	5933905	c.7199A>G/c.13934G>A	{"RYR1": {"c.7199A>G": 1, "c.13934G>A": 1}}	\N
5935000	5933905	c.992_994dup/c.14825G>T	{"RYR1": {"c.14825G>T": 1, "c.992_994dup": 1}}	\N
5935001	5933905	c.1411C>T/c.6757C>T	{"RYR1": {"c.1411C>T": 1, "c.6757C>T": 1}}	\N
5935002	5933905	c.10252A>G/c.10556C>T	{"RYR1": {"c.10252A>G": 1, "c.10556C>T": 1}}	\N
5935003	5933905	c.212C>A/c.12383C>T	{"RYR1": {"c.212C>A": 1, "c.12383C>T": 1}}	\N
5935004	5933905	c.3172G>A/c.6599C>T	{"RYR1": {"c.3172G>A": 1, "c.6599C>T": 1}}	\N
5935005	5933905	c.131G>A/c.11813G>A	{"RYR1": {"c.131G>A": 1, "c.11813G>A": 1}}	\N
5935006	5933905	c.4400A>G/c.8638G>A	{"RYR1": {"c.4400A>G": 1, "c.8638G>A": 1}}	\N
5935007	5933905	c.2050G>C/c.2654G>A	{"RYR1": {"c.2050G>C": 1, "c.2654G>A": 1}}	\N
5935008	5933905	c.479A>G/c.3527C>T	{"RYR1": {"c.479A>G": 1, "c.3527C>T": 1}}	\N
5908712	5908711	A	{"G6PD": {"A": 1}}	\N
5935009	5933905	c.7307G>A/c.10042C>T	{"RYR1": {"c.7307G>A": 1, "c.10042C>T": 1}}	\N
5935010	5933905	c.1453A>G/c.12355A>T	{"RYR1": {"c.1453A>G": 1, "c.12355A>T": 1}}	\N
5935011	5933905	c.1422G>T/c.12413T>C	{"RYR1": {"c.1422G>T": 1, "c.12413T>C": 1}}	\N
5935012	5933905	c.8638G>A/c.14825G>T	{"RYR1": {"c.8638G>A": 1, "c.14825G>T": 1}}	\N
5935013	5933905	c.493G>A/c.493G>A	{"RYR1": {"c.493G>A": 2}}	\N
5935014	5933905	c.7210G>A/c.14458G>T	{"RYR1": {"c.7210G>A": 1, "c.14458G>T": 1}}	\N
5935015	5933905	c.1411C>T/c.13702C>G	{"RYR1": {"c.1411C>T": 1, "c.13702C>G": 1}}	\N
5935016	5933905	c.14270G>A/c.14458G>A	{"RYR1": {"c.14270G>A": 1, "c.14458G>A": 1}}	\N
5935017	5933905	c.9676G>C/c.14449A>T	{"RYR1": {"c.9676G>C": 1, "c.14449A>T": 1}}	\N
5935018	5933905	c.12121C>T/c.14782A>G	{"RYR1": {"c.12121C>T": 1, "c.14782A>G": 1}}	\N
5935019	5933905	c.9499C>T/c.14639T>C	{"RYR1": {"c.9499C>T": 1, "c.14639T>C": 1}}	\N
5935020	5933905	c.5024T>C/c.11086G>C	{"RYR1": {"c.5024T>C": 1, "c.11086G>C": 1}}	\N
5935021	5933905	c.6302T>A/c.11120G>T	{"RYR1": {"c.6302T>A": 1, "c.11120G>T": 1}}	\N
5935022	5933905	c.131G>A/c.6037A>C	{"RYR1": {"c.131G>A": 1, "c.6037A>C": 1}}	\N
5935023	5933905	c.1834G>C/c.13760C>T	{"RYR1": {"c.1834G>C": 1, "c.13760C>T": 1}}	\N
5935024	5933905	c.6478G>A/c.14813T>C	{"RYR1": {"c.6478G>A": 1, "c.14813T>C": 1}}	\N
5935025	5933905	c.3418C>T/c.9356G>A	{"RYR1": {"c.3418C>T": 1, "c.9356G>A": 1}}	\N
5935026	5933905	c.1100G>A/c.8729C>T	{"RYR1": {"c.1100G>A": 1, "c.8729C>T": 1}}	\N
5935027	5933905	c.7085A>G/c.11518G>A	{"RYR1": {"c.7085A>G": 1, "c.11518G>A": 1}}	\N
5935028	5933905	c.5132A>G/c.6302T>A	{"RYR1": {"c.5132A>G": 1, "c.6302T>A": 1}}	\N
5935029	5933905	c.6377G>A/c.7355G>A	{"RYR1": {"c.6377G>A": 1, "c.7355G>A": 1}}	\N
5935030	5933905	c.6377G>A/c.7355G>C	{"RYR1": {"c.6377G>A": 1, "c.7355G>C": 1}}	\N
5935031	5933905	c.8005G>A/c.8005G>A	{"RYR1": {"c.8005G>A": 2}}	\N
5935032	5933905	c.992_994dup/c.14524G>A	{"RYR1": {"c.14524G>A": 1, "c.992_994dup": 1}}	\N
5935033	5933905	c.2122G>A/c.11723A>T	{"RYR1": {"c.2122G>A": 1, "c.11723A>T": 1}}	\N
5935034	5933905	c.7292A>T/c.9676G>C	{"RYR1": {"c.7292A>T": 1, "c.9676G>C": 1}}	\N
5935035	5933905	c.12848A>T/c.13505A>G	{"RYR1": {"c.12848A>T": 1, "c.13505A>G": 1}}	\N
5935036	5933905	c.1201C>G/c.14879T>A	{"RYR1": {"c.1201C>G": 1, "c.14879T>A": 1}}	\N
5935037	5933905	c.6635T>A/c.12115A>T	{"RYR1": {"c.6635T>A": 1, "c.12115A>T": 1}}	\N
5935038	5933905	c.992_994dup/c.8518C>T	{"RYR1": {"c.8518C>T": 1, "c.992_994dup": 1}}	\N
5935039	5933905	c.11120G>T/c.14422_14423delinsAA	{"RYR1": {"c.11120G>T": 1, "c.14422_14423delinsAA": 1}}	\N
5935040	5933905	c.455C>A/c.11314C>T	{"RYR1": {"c.455C>A": 1, "c.11314C>T": 1}}	\N
5935041	5933905	c.6377G>A/c.8188G>C	{"RYR1": {"c.6377G>A": 1, "c.8188G>C": 1}}	\N
5935042	5933905	c.6478G>A/c.8729C>T	{"RYR1": {"c.6478G>A": 1, "c.8729C>T": 1}}	\N
5935043	5933905	c.8600T>A/c.13672C>T	{"RYR1": {"c.8600T>A": 1, "c.13672C>T": 1}}	\N
5935044	5933905	c.528G>T/c.1453A>G	{"RYR1": {"c.528G>T": 1, "c.1453A>G": 1}}	\N
5935045	5933905	c.8198G>A/c.14558C>T	{"RYR1": {"c.8198G>A": 1, "c.14558C>T": 1}}	\N
5935046	5933905	c.652G>A/c.1453A>G	{"RYR1": {"c.652G>A": 1, "c.1453A>G": 1}}	\N
5935047	5933905	c.4763C>T/c.10237A>T	{"RYR1": {"c.4763C>T": 1, "c.10237A>T": 1}}	\N
5935048	5933905	c.5132A>G/c.12121C>T	{"RYR1": {"c.5132A>G": 1, "c.12121C>T": 1}}	\N
5935049	5933905	c.1144C>A/c.8054C>T	{"RYR1": {"c.1144C>A": 1, "c.8054C>T": 1}}	\N
5935050	5933905	c.12355A>T/c.14567C>G	{"RYR1": {"c.12355A>T": 1, "c.14567C>G": 1}}	\N
5935051	5933905	c.7760A>G/c.14678G>A	{"RYR1": {"c.7760A>G": 1, "c.14678G>A": 1}}	\N
5935052	5933905	c.1597C>A/c.14782A>G	{"RYR1": {"c.1597C>A": 1, "c.14782A>G": 1}}	\N
5935053	5933905	c.652G>A/c.14558C>T	{"RYR1": {"c.652G>A": 1, "c.14558C>T": 1}}	\N
5935054	5933905	c.680A>T/c.11126C>T	{"RYR1": {"c.680A>T": 1, "c.11126C>T": 1}}	\N
5935055	5933905	c.12028G>A/c.13913G>A	{"RYR1": {"c.12028G>A": 1, "c.13913G>A": 1}}	\N
5935056	5933905	c.1453A>G/c.10042C>T	{"RYR1": {"c.1453A>G": 1, "c.10042C>T": 1}}	\N
5935057	5933905	c.6377G>A/c.11953T>C	{"RYR1": {"c.6377G>A": 1, "c.11953T>C": 1}}	\N
5935058	5933905	c.7760A>G/c.14387A>G	{"RYR1": {"c.7760A>G": 1, "c.14387A>G": 1}}	\N
5935059	5933905	c.7528T>C/c.14567C>G	{"RYR1": {"c.7528T>C": 1, "c.14567C>G": 1}}	\N
5935060	5933905	c.9499C>T/c.14879T>A	{"RYR1": {"c.9499C>T": 1, "c.14879T>A": 1}}	\N
5935061	5933905	c.8638G>A/c.10043G>A	{"RYR1": {"c.8638G>A": 1, "c.10043G>A": 1}}	\N
5935062	5933905	c.11120G>T/c.12413T>C	{"RYR1": {"c.11120G>T": 1, "c.12413T>C": 1}}	\N
5935063	5933905	c.5033A>G/c.12533G>T	{"RYR1": {"c.5033A>G": 1, "c.12533G>T": 1}}	\N
5935064	5933905	c.6757C>T/c.9797T>C	{"RYR1": {"c.6757C>T": 1, "c.9797T>C": 1}}	\N
5935065	5933905	c.10556C>T/c.11132C>T	{"RYR1": {"c.10556C>T": 1, "c.11132C>T": 1}}	\N
5935066	5933905	c.3656A>C/c.10556C>T	{"RYR1": {"c.3656A>C": 1, "c.10556C>T": 1}}	\N
5935067	5933905	c.251C>T/c.13702C>G	{"RYR1": {"c.251C>T": 1, "c.13702C>G": 1}}	\N
5935068	5933905	c.7075C>T/c.9635A>G	{"RYR1": {"c.7075C>T": 1, "c.9635A>G": 1}}	\N
5935069	5933905	c.533A>C/c.7355G>C	{"RYR1": {"c.533A>C": 1, "c.7355G>C": 1}}	\N
5935070	5933905	c.497A>G/c.14126C>T	{"RYR1": {"c.497A>G": 1, "c.14126C>T": 1}}	\N
5935071	5933905	c.533A>C/c.7355G>A	{"RYR1": {"c.533A>C": 1, "c.7355G>A": 1}}	\N
5935072	5933905	c.6847A>C/c.10043G>A	{"RYR1": {"c.6847A>C": 1, "c.10043G>A": 1}}	\N
5935073	5933905	c.12028G>A/c.12689T>G	{"RYR1": {"c.12028G>A": 1, "c.12689T>G": 1}}	\N
5935074	5933905	c.1144C>A/c.12689T>G	{"RYR1": {"c.1144C>A": 1, "c.12689T>G": 1}}	\N
5935075	5933905	c.533A>C/c.6635T>A	{"RYR1": {"c.533A>C": 1, "c.6635T>A": 1}}	\N
5935076	5933905	c.3656A>C/c.7879G>A	{"RYR1": {"c.3656A>C": 1, "c.7879G>A": 1}}	\N
5935077	5933905	c.14126C>T/c.14782A>G	{"RYR1": {"c.14126C>T": 1, "c.14782A>G": 1}}	\N
5935078	5933905	c.12028G>A/c.13673G>A	{"RYR1": {"c.12028G>A": 1, "c.13673G>A": 1}}	\N
5935079	5933905	c.3418C>T/c.11958C>G	{"RYR1": {"c.3418C>T": 1, "c.11958C>G": 1}}	\N
5935080	5933905	c.7292A>T/c.12064A>G	{"RYR1": {"c.7292A>T": 1, "c.12064A>G": 1}}	\N
5935081	5933905	c.1598G>A/c.14197T>G	{"RYR1": {"c.1598G>A": 1, "c.14197T>G": 1}}	\N
5935082	5933905	c.5024T>C/c.14782A>G	{"RYR1": {"c.5024T>C": 1, "c.14782A>G": 1}}	\N
5935083	5933905	c.190T>C/c.7385C>T	{"RYR1": {"c.190T>C": 1, "c.7385C>T": 1}}	\N
5935084	5933905	c.946C>T/c.7199A>G	{"RYR1": {"c.946C>T": 1, "c.7199A>G": 1}}	\N
5935085	5933905	c.467G>A/c.9758T>C	{"RYR1": {"c.467G>A": 1, "c.9758T>C": 1}}	\N
5935086	5933905	c.3127C>T/c.13505A>G	{"RYR1": {"c.3127C>T": 1, "c.13505A>G": 1}}	\N
5935087	5933905	c.5441T>A/c.10891G>T	{"RYR1": {"c.5441T>A": 1, "c.10891G>T": 1}}	\N
5935088	5933905	c.6671G>A/c.14422_14423delinsAA	{"RYR1": {"c.6671G>A": 1, "c.14422_14423delinsAA": 1}}	\N
5935089	5933905	c.1598G>A/c.13672C>T	{"RYR1": {"c.1598G>A": 1, "c.13672C>T": 1}}	\N
5935090	5933905	c.2537C>T/c.9268G>A	{"RYR1": {"c.2537C>T": 1, "c.9268G>A": 1}}	\N
5935091	5933905	c.680A>T/c.7292A>T	{"RYR1": {"c.680A>T": 1, "c.7292A>T": 1}}	\N
5935092	5933905	c.131G>A/c.7760A>G	{"RYR1": {"c.131G>A": 1, "c.7760A>G": 1}}	\N
5935093	5933905	c.467G>A/c.4400A>G	{"RYR1": {"c.467G>A": 1, "c.4400A>G": 1}}	\N
5935094	5933905	c.6388G>A/c.13990T>C	{"RYR1": {"c.6388G>A": 1, "c.13990T>C": 1}}	\N
5935095	5933905	c.9356G>A/c.13913G>A	{"RYR1": {"c.9356G>A": 1, "c.13913G>A": 1}}	\N
5935096	5933905	c.4775C>T/c.7199A>G	{"RYR1": {"c.4775C>T": 1, "c.7199A>G": 1}}	\N
5935097	5933905	c.1422G>T/c.11953T>C	{"RYR1": {"c.1422G>T": 1, "c.11953T>C": 1}}	\N
5935098	5933905	c.11120G>T/c.13913G>A	{"RYR1": {"c.11120G>T": 1, "c.13913G>A": 1}}	\N
5935099	5933905	c.7778G>A/c.11958C>G	{"RYR1": {"c.7778G>A": 1, "c.11958C>G": 1}}	\N
5935100	5933905	c.6544A>T/c.12413T>C	{"RYR1": {"c.6544A>T": 1, "c.12413T>C": 1}}	\N
5935101	5933905	c.3172G>A/c.14581C>T	{"RYR1": {"c.3172G>A": 1, "c.14581C>T": 1}}	\N
5935102	5933905	c.467G>A/c.11947C>T	{"RYR1": {"c.467G>A": 1, "c.11947C>T": 1}}	\N
5935103	5933905	c.6742C>T/c.7018T>C	{"RYR1": {"c.6742C>T": 1, "c.7018T>C": 1}}	\N
5935104	5933905	c.13918A>G/c.15059G>C	{"RYR1": {"c.13918A>G": 1, "c.15059G>C": 1}}	\N
5935105	5933905	c.11953T>C/c.13990T>C	{"RYR1": {"c.11953T>C": 1, "c.13990T>C": 1}}	\N
5935106	5933905	c.455C>A/c.14581C>T	{"RYR1": {"c.455C>A": 1, "c.14581C>T": 1}}	\N
5935107	5933905	c.5441T>A/c.7778G>A	{"RYR1": {"c.5441T>A": 1, "c.7778G>A": 1}}	\N
5935108	5933905	c.5440A>G/c.6640G>A	{"RYR1": {"c.5440A>G": 1, "c.6640G>A": 1}}	\N
5935109	5933905	c.1144C>A/c.13913G>A	{"RYR1": {"c.1144C>A": 1, "c.13913G>A": 1}}	\N
5935110	5933905	c.13994_13995delTCinsCT/c.14509C>G	{"RYR1": {"c.14509C>G": 1, "c.13994_13995delTCinsCT": 1}}	\N
5935111	5933905	c.1453A>G/c.11126C>T	{"RYR1": {"c.1453A>G": 1, "c.11126C>T": 1}}	\N
5935112	5933905	c.6377G>A/c.6635T>A	{"RYR1": {"c.6377G>A": 1, "c.6635T>A": 1}}	\N
5935113	5933905	c.1100G>T/c.9797T>C	{"RYR1": {"c.1100G>T": 1, "c.9797T>C": 1}}	\N
5935114	5933905	c.178G>T/c.6037A>C	{"RYR1": {"c.178G>T": 1, "c.6037A>C": 1}}	\N
5935115	5933905	c.1100G>T/c.11086G>C	{"RYR1": {"c.1100G>T": 1, "c.11086G>C": 1}}	\N
5935116	5933905	c.5024T>C/c.14817C>A	{"RYR1": {"c.5024T>C": 1, "c.14817C>A": 1}}	\N
5935117	5933905	c.3095G>A/c.10891G>T	{"RYR1": {"c.3095G>A": 1, "c.10891G>T": 1}}	\N
5935118	5933905	c.2537C>T/c.3418C>T	{"RYR1": {"c.2537C>T": 1, "c.3418C>T": 1}}	\N
5935119	5933905	c.488G>A/c.1201C>A	{"RYR1": {"c.488G>A": 1, "c.1201C>A": 1}}	\N
5935120	5933905	c.13913G>A/c.14270G>A	{"RYR1": {"c.13913G>A": 1, "c.14270G>A": 1}}	\N
5935121	5933905	c.488G>A/c.1201C>G	{"RYR1": {"c.488G>A": 1, "c.1201C>G": 1}}	\N
5935122	5933905	c.11086G>C/c.11086G>C	{"RYR1": {"c.11086G>C": 2}}	\N
5935123	5933905	c.13918A>G/c.15060G>C	{"RYR1": {"c.13918A>G": 1, "c.15060G>C": 1}}	\N
5935124	5933905	c.190T>C/c.14449A>T	{"RYR1": {"c.190T>C": 1, "c.14449A>T": 1}}	\N
5935125	5933905	c.12553G>A/c.14678G>A	{"RYR1": {"c.12553G>A": 1, "c.14678G>A": 1}}	\N
5935126	5933905	c.528G>T/c.7771C>G	{"RYR1": {"c.528G>T": 1, "c.7771C>G": 1}}	\N
5935127	5933905	c.7777C>G/c.14422_14423delinsAA	{"RYR1": {"c.7777C>G": 1, "c.14422_14423delinsAA": 1}}	\N
5935128	5933905	c.7097C>G/c.11120G>T	{"RYR1": {"c.7097C>G": 1, "c.11120G>T": 1}}	\N
5935129	5933905	c.7112A>G/c.12383C>T	{"RYR1": {"c.7112A>G": 1, "c.12383C>T": 1}}	\N
5935130	5933905	c.7487C>T/c.13918A>G	{"RYR1": {"c.7487C>T": 1, "c.13918A>G": 1}}	\N
5935131	5933905	c.9356G>A/c.14422_14423delinsAA	{"RYR1": {"c.9356G>A": 1, "c.14422_14423delinsAA": 1}}	\N
5935132	5933905	c.3667G>A/c.8527T>C	{"RYR1": {"c.3667G>A": 1, "c.8527T>C": 1}}	\N
5935133	5933905	c.10042C>T/c.13702C>G	{"RYR1": {"c.10042C>T": 1, "c.13702C>G": 1}}	\N
5935134	5933905	c.641C>T/c.1411C>T	{"RYR1": {"c.641C>T": 1, "c.1411C>T": 1}}	\N
5935135	5933905	c.7085A>G/c.10891G>T	{"RYR1": {"c.7085A>G": 1, "c.10891G>T": 1}}	\N
5935136	5933905	c.6037A>C/c.6388G>A	{"RYR1": {"c.6037A>C": 1, "c.6388G>A": 1}}	\N
5935137	5933905	c.11947C>T/c.12533G>T	{"RYR1": {"c.11947C>T": 1, "c.12533G>T": 1}}	\N
5935138	5933905	c.947G>T/c.7528T>C	{"RYR1": {"c.947G>T": 1, "c.7528T>C": 1}}	\N
5935139	5933905	c.6640G>A/c.12355A>T	{"RYR1": {"c.6640G>A": 1, "c.12355A>T": 1}}	\N
5935140	5933905	c.5132A>G/c.14567C>G	{"RYR1": {"c.5132A>G": 1, "c.14567C>G": 1}}	\N
5935141	5933905	c.51_53del/c.6302T>A	{"RYR1": {"c.6302T>A": 1, "c.51_53del": 1}}	\N
5935142	5933905	c.1209C>G/c.13505A>G	{"RYR1": {"c.1209C>G": 1, "c.13505A>G": 1}}	\N
5935143	5933905	c.479A>G/c.7771C>G	{"RYR1": {"c.479A>G": 1, "c.7771C>G": 1}}	\N
5935144	5933905	c.178G>T/c.10042C>T	{"RYR1": {"c.178G>T": 1, "c.10042C>T": 1}}	\N
5935145	5933905	c.1024G>A/c.7777C>G	{"RYR1": {"c.1024G>A": 1, "c.7777C>G": 1}}	\N
5935146	5933905	c.6742C>T/c.7085A>G	{"RYR1": {"c.6742C>T": 1, "c.7085A>G": 1}}	\N
5935147	5933905	c.9356G>A/c.12413T>C	{"RYR1": {"c.9356G>A": 1, "c.12413T>C": 1}}	\N
5935148	5933905	c.652G>A/c.3418C>T	{"RYR1": {"c.652G>A": 1, "c.3418C>T": 1}}	\N
5935149	5933905	c.6037A>C/c.6640G>A	{"RYR1": {"c.6037A>C": 1, "c.6640G>A": 1}}	\N
5935150	5933905	c.8527T>C/c.9850T>A	{"RYR1": {"c.8527T>C": 1, "c.9850T>A": 1}}	\N
5935151	5933905	c.131G>A/c.2122G>A	{"RYR1": {"c.131G>A": 1, "c.2122G>A": 1}}	\N
5935152	5933905	c.7292A>T/c.9652G>A	{"RYR1": {"c.7292A>T": 1, "c.9652G>A": 1}}	\N
5935153	5933905	c.6743G>A/c.11723A>T	{"RYR1": {"c.6743G>A": 1, "c.11723A>T": 1}}	\N
5935154	5933905	c.3418C>T/c.14364+1G>T	{"RYR1": {"c.3418C>T": 1, "c.14364+1G>T": 1}}	\N
5935155	5933905	c.6544A>T/c.14422_14423delinsAA	{"RYR1": {"c.6544A>T": 1, "c.14422_14423delinsAA": 1}}	\N
5935156	5933905	c.7778G>A/c.14364+1G>T	{"RYR1": {"c.7778G>A": 1, "c.14364+1G>T": 1}}	\N
5935157	5933905	c.6037A>C/c.14968A>G	{"RYR1": {"c.6037A>C": 1, "c.14968A>G": 1}}	\N
5935158	5933905	c.11958C>G/c.14581C>T	{"RYR1": {"c.11958C>G": 1, "c.14581C>T": 1}}	\N
5935159	5933905	c.7018T>C/c.14270G>A	{"RYR1": {"c.7018T>C": 1, "c.14270G>A": 1}}	\N
5935160	5933905	c.7112A>G/c.11748T>G	{"RYR1": {"c.7112A>G": 1, "c.11748T>G": 1}}	\N
5935161	5933905	c.7777C>G/c.12413T>C	{"RYR1": {"c.7777C>G": 1, "c.12413T>C": 1}}	\N
5935162	5933905	c.496G>A/c.6635T>A	{"RYR1": {"c.496G>A": 1, "c.6635T>A": 1}}	\N
5935163	5933905	c.625G>A/c.10237A>T	{"RYR1": {"c.625G>A": 1, "c.10237A>T": 1}}	\N
5935164	5933905	c.1834G>C/c.14002C>T	{"RYR1": {"c.1834G>C": 1, "c.14002C>T": 1}}	\N
5935165	5933905	c.51_53del/c.3127C>T	{"RYR1": {"c.3127C>T": 1, "c.51_53del": 1}}	\N
5935166	5933905	c.7771C>G/c.12383C>T	{"RYR1": {"c.7771C>G": 1, "c.12383C>T": 1}}	\N
5935167	5933905	c.479A>G/c.7771C>T	{"RYR1": {"c.479A>G": 1, "c.7771C>T": 1}}	\N
5935168	5933905	c.11314C>T/c.14509C>G	{"RYR1": {"c.11314C>T": 1, "c.14509C>G": 1}}	\N
5935169	5933905	c.7307G>A/c.11126C>T	{"RYR1": {"c.7307G>A": 1, "c.11126C>T": 1}}	\N
5935170	5933905	c.14051T>C/c.14471T>C	{"RYR1": {"c.14051T>C": 1, "c.14471T>C": 1}}	\N
5935171	5933905	c.3667G>A/c.13994_13995delTCinsCT	{"RYR1": {"c.3667G>A": 1, "c.13994_13995delTCinsCT": 1}}	\N
5935172	5933905	c.7528T>C/c.12121C>T	{"RYR1": {"c.7528T>C": 1, "c.12121C>T": 1}}	\N
5935173	5933905	c.9850T>A/c.12689T>G	{"RYR1": {"c.9850T>A": 1, "c.12689T>G": 1}}	\N
5935174	5933905	c.528G>T/c.3418C>T	{"RYR1": {"c.528G>T": 1, "c.3418C>T": 1}}	\N
5935175	5933905	c.6757C>T/c.11086G>C	{"RYR1": {"c.6757C>T": 1, "c.11086G>C": 1}}	\N
5935176	5933905	c.2537C>T/c.7097C>G	{"RYR1": {"c.2537C>T": 1, "c.7097C>G": 1}}	\N
5935177	5933905	c.5024T>C/c.5024T>C	{"RYR1": {"c.5024T>C": 2}}	\N
5935178	5933905	c.10043G>A/c.14424C>A	{"RYR1": {"c.10043G>A": 1, "c.14424C>A": 1}}	\N
5935179	5933905	c.1144C>A/c.13673G>A	{"RYR1": {"c.1144C>A": 1, "c.13673G>A": 1}}	\N
5935180	5933905	c.119G>C/c.13990T>C	{"RYR1": {"c.119G>C": 1, "c.13990T>C": 1}}	\N
5935181	5933905	c.178G>A/c.8198G>A	{"RYR1": {"c.178G>A": 1, "c.8198G>A": 1}}	\N
5935182	5933905	c.1201C>A/c.14879T>A	{"RYR1": {"c.1201C>A": 1, "c.14879T>A": 1}}	\N
5935183	5933905	c.5440A>G/c.13934G>A	{"RYR1": {"c.5440A>G": 1, "c.13934G>A": 1}}	\N
5935184	5933905	c.7199A>G/c.11126C>T	{"RYR1": {"c.7199A>G": 1, "c.11126C>T": 1}}	\N
5935185	5933905	c.677T>A/c.14825G>T	{"RYR1": {"c.677T>A": 1, "c.14825G>T": 1}}	\N
5935186	5933905	c.51_53del/c.178G>T	{"RYR1": {"c.178G>T": 1, "c.51_53del": 1}}	\N
5935187	5933905	c.7073T>A/c.12028G>A	{"RYR1": {"c.7073T>A": 1, "c.12028G>A": 1}}	\N
5935188	5933905	c.12383C>T/c.14968A>G	{"RYR1": {"c.12383C>T": 1, "c.14968A>G": 1}}	\N
5935189	5933905	c.14422_14423delinsAA/c.14424C>A	{"RYR1": {"c.14424C>A": 1, "c.14422_14423delinsAA": 1}}	\N
5935190	5933905	c.190T>C/c.14680G>A	{"RYR1": {"c.190T>C": 1, "c.14680G>A": 1}}	\N
5935191	5933905	c.131G>A/c.1024G>A	{"RYR1": {"c.131G>A": 1, "c.1024G>A": 1}}	\N
5935192	5933905	c.9848G>A/c.12383C>T	{"RYR1": {"c.9848G>A": 1, "c.12383C>T": 1}}	\N
5935193	5933905	c.1460T>C/c.14567C>G	{"RYR1": {"c.1460T>C": 1, "c.14567C>G": 1}}	\N
5935194	5933905	c.8729C>T/c.14186A>C	{"RYR1": {"c.8729C>T": 1, "c.14186A>C": 1}}	\N
5935195	5933905	c.1411C>T/c.9652G>A	{"RYR1": {"c.1411C>T": 1, "c.9652G>A": 1}}	\N
5935196	5933905	c.3418C>T/c.7210G>A	{"RYR1": {"c.3418C>T": 1, "c.7210G>A": 1}}	\N
5935197	5933905	c.488G>A/c.13918A>G	{"RYR1": {"c.488G>A": 1, "c.13918A>G": 1}}	\N
5935198	5933905	c.7018T>C/c.14002C>T	{"RYR1": {"c.7018T>C": 1, "c.14002C>T": 1}}	\N
5935199	5933905	c.455C>A/c.14678G>A	{"RYR1": {"c.455C>A": 1, "c.14678G>A": 1}}	\N
5935200	5933905	c.6710G>A/c.7292A>T	{"RYR1": {"c.6710G>A": 1, "c.7292A>T": 1}}	\N
5935201	5933905	c.11518G>A/c.12413T>C	{"RYR1": {"c.11518G>A": 1, "c.12413T>C": 1}}	\N
5935202	5933905	c.947G>T/c.13672C>T	{"RYR1": {"c.947G>T": 1, "c.13672C>T": 1}}	\N
5935203	5933905	c.1597C>A/c.7777C>G	{"RYR1": {"c.1597C>A": 1, "c.7777C>G": 1}}	\N
5935204	5933905	c.8198G>A/c.10750G>C	{"RYR1": {"c.8198G>A": 1, "c.10750G>C": 1}}	\N
5935205	5933905	c.1422G>T/c.3667G>A	{"RYR1": {"c.1422G>T": 1, "c.3667G>A": 1}}	\N
5935206	5933905	c.652G>A/c.7771C>G	{"RYR1": {"c.652G>A": 1, "c.7771C>G": 1}}	\N
5935207	5933905	c.13934G>A/c.14197T>G	{"RYR1": {"c.13934G>A": 1, "c.14197T>G": 1}}	\N
5935208	5933905	c.6742C>T/c.14524G>A	{"RYR1": {"c.6742C>T": 1, "c.14524G>A": 1}}	\N
5935209	5933905	c.10556C>T/c.14813T>C	{"RYR1": {"c.10556C>T": 1, "c.14813T>C": 1}}	\N
5935210	5933905	c.467G>A/c.7073T>A	{"RYR1": {"c.467G>A": 1, "c.7073T>A": 1}}	\N
5935211	5933905	c.2654G>A/c.7528T>C	{"RYR1": {"c.2654G>A": 1, "c.7528T>C": 1}}	\N
5935212	5933905	c.7385C>T/c.8189A>G	{"RYR1": {"c.7385C>T": 1, "c.8189A>G": 1}}	\N
5935213	5933905	c.1475G>A/c.9356G>A	{"RYR1": {"c.1475G>A": 1, "c.9356G>A": 1}}	\N
5935214	5933905	c.178G>A/c.2122G>A	{"RYR1": {"c.178G>A": 1, "c.2122G>A": 1}}	\N
5935215	5933905	c.51_53del/c.178G>A	{"RYR1": {"c.178G>A": 1, "c.51_53del": 1}}	\N
5935216	5933905	c.190T>C/c.5341T>C	{"RYR1": {"c.190T>C": 1, "c.5341T>C": 1}}	\N
5935217	5933905	c.11518G>A/c.14422_14423delinsAA	{"RYR1": {"c.11518G>A": 1, "c.14422_14423delinsAA": 1}}	\N
5935218	5933905	c.9868G>A/c.13760C>T	{"RYR1": {"c.9868G>A": 1, "c.13760C>T": 1}}	\N
5935219	5933905	c.1453A>G/c.6037A>C	{"RYR1": {"c.1453A>G": 1, "c.6037A>C": 1}}	\N
5935220	5933905	c.5024T>C/c.6478G>A	{"RYR1": {"c.5024T>C": 1, "c.6478G>A": 1}}	\N
5935221	5933905	c.1460T>C/c.12121C>T	{"RYR1": {"c.1460T>C": 1, "c.12121C>T": 1}}	\N
5935222	5933905	c.6847A>C/c.14201G>A	{"RYR1": {"c.6847A>C": 1, "c.14201G>A": 1}}	\N
5935223	5933905	c.9797T>C/c.14364+1G>T	{"RYR1": {"c.9797T>C": 1, "c.14364+1G>T": 1}}	\N
5935224	5933905	c.1460T>C/c.6302T>A	{"RYR1": {"c.1460T>C": 1, "c.6302T>A": 1}}	\N
5935225	5933905	c.652G>A/c.7771C>T	{"RYR1": {"c.652G>A": 1, "c.7771C>T": 1}}	\N
5935226	5933905	c.251C>T/c.7099G>A	{"RYR1": {"c.251C>T": 1, "c.7099G>A": 1}}	\N
5935227	5933905	c.9268G>A/c.12553G>A	{"RYR1": {"c.9268G>A": 1, "c.12553G>A": 1}}	\N
5935228	5933905	c.7879G>A/c.14818G>A	{"RYR1": {"c.7879G>A": 1, "c.14818G>A": 1}}	\N
5935229	5933905	c.6302T>A/c.14782A>G	{"RYR1": {"c.6302T>A": 1, "c.14782A>G": 1}}	\N
5935230	5933905	c.7317G>C/c.10229C>A	{"RYR1": {"c.7317G>C": 1, "c.10229C>A": 1}}	\N
5935231	5933905	c.6742C>T/c.14126C>T	{"RYR1": {"c.6742C>T": 1, "c.14126C>T": 1}}	\N
5935232	5933905	c.652G>A/c.14509C>G	{"RYR1": {"c.652G>A": 1, "c.14509C>G": 1}}	\N
5935233	5933905	c.7777C>G/c.14818G>A	{"RYR1": {"c.7777C>G": 1, "c.14818G>A": 1}}	\N
5935234	5933905	c.51_53del/c.12532G>A	{"RYR1": {"c.12532G>A": 1, "c.51_53del": 1}}	\N
5935235	5933905	c.6847A>C/c.11416G>A	{"RYR1": {"c.6847A>C": 1, "c.11416G>A": 1}}	\N
5935236	5933905	c.7760A>G/c.14581C>T	{"RYR1": {"c.7760A>G": 1, "c.14581C>T": 1}}	\N
5935237	5933905	c.7355G>A/c.12115A>T	{"RYR1": {"c.7355G>A": 1, "c.12115A>T": 1}}	\N
5935238	5933905	c.8198G>A/c.14509C>G	{"RYR1": {"c.8198G>A": 1, "c.14509C>G": 1}}	\N
5935239	5933905	c.4763C>T/c.14458G>A	{"RYR1": {"c.4763C>T": 1, "c.14458G>A": 1}}	\N
5935240	5933905	c.7097C>G/c.14817C>A	{"RYR1": {"c.7097C>G": 1, "c.14817C>A": 1}}	\N
5935241	5933905	c.11132C>T/c.12064A>G	{"RYR1": {"c.11132C>T": 1, "c.12064A>G": 1}}	\N
5935242	5933905	c.467G>A/c.6548G>A	{"RYR1": {"c.467G>A": 1, "c.6548G>A": 1}}	\N
5935243	5933905	c.4775C>T/c.7778G>A	{"RYR1": {"c.4775C>T": 1, "c.7778G>A": 1}}	\N
5935244	5933905	c.7771C>T/c.11748T>G	{"RYR1": {"c.7771C>T": 1, "c.11748T>G": 1}}	\N
5935245	5933905	c.7099G>A/c.11947C>T	{"RYR1": {"c.7099G>A": 1, "c.11947C>T": 1}}	\N
5935246	5933905	c.131G>A/c.8198G>A	{"RYR1": {"c.131G>A": 1, "c.8198G>A": 1}}	\N
5935247	5933905	c.6544A>T/c.7528T>C	{"RYR1": {"c.6544A>T": 1, "c.7528T>C": 1}}	\N
5935248	5933905	c.131G>A/c.1422G>T	{"RYR1": {"c.131G>A": 1, "c.1422G>T": 1}}	\N
5935249	5933905	c.11723A>T/c.12028G>A	{"RYR1": {"c.11723A>T": 1, "c.12028G>A": 1}}	\N
5935250	5933905	c.11748T>G/c.11958C>G	{"RYR1": {"c.11748T>G": 1, "c.11958C>G": 1}}	\N
5935251	5933905	c.946C>T/c.14782A>G	{"RYR1": {"c.946C>T": 1, "c.14782A>G": 1}}	\N
5935252	5933905	c.7522C>G/c.14825G>T	{"RYR1": {"c.7522C>G": 1, "c.14825G>T": 1}}	\N
5935253	5933905	c.7317G>C/c.7385C>T	{"RYR1": {"c.7317G>C": 1, "c.7385C>T": 1}}	\N
5935254	5933905	c.7075C>T/c.10229C>A	{"RYR1": {"c.7075C>T": 1, "c.10229C>A": 1}}	\N
5935255	5933905	c.6304G>C/c.13918A>G	{"RYR1": {"c.6304G>C": 1, "c.13918A>G": 1}}	\N
5935256	5933905	c.4763C>T/c.14458G>T	{"RYR1": {"c.4763C>T": 1, "c.14458G>T": 1}}	\N
5935257	5933905	c.7210G>A/c.14693T>C	{"RYR1": {"c.7210G>A": 1, "c.14693T>C": 1}}	\N
5935258	5933905	c.7099G>A/c.11120G>T	{"RYR1": {"c.7099G>A": 1, "c.11120G>T": 1}}	\N
5935259	5933905	c.14364+1G>T/c.14782A>G	{"RYR1": {"c.14782A>G": 1, "c.14364+1G>T": 1}}	\N
5935260	5933905	c.1834G>C/c.6742C>T	{"RYR1": {"c.1834G>C": 1, "c.6742C>T": 1}}	\N
5935261	5933905	c.2050G>C/c.14422_14423delinsAA	{"RYR1": {"c.2050G>C": 1, "c.14422_14423delinsAA": 1}}	\N
5935262	5933905	c.3667G>A/c.11416G>A	{"RYR1": {"c.3667G>A": 1, "c.11416G>A": 1}}	\N
5935263	5933905	c.12115A>T/c.14270G>A	{"RYR1": {"c.12115A>T": 1, "c.14270G>A": 1}}	\N
5935264	5933905	c.5132A>G/c.12398A>G	{"RYR1": {"c.5132A>G": 1, "c.12398A>G": 1}}	\N
5935265	5933905	c.5341T>C/c.11120G>T	{"RYR1": {"c.5341T>C": 1, "c.11120G>T": 1}}	\N
5935266	5933905	c.13702C>G/c.15059G>C	{"RYR1": {"c.13702C>G": 1, "c.15059G>C": 1}}	\N
5935267	5933905	c.1460T>C/c.6671G>A	{"RYR1": {"c.1460T>C": 1, "c.6671G>A": 1}}	\N
5935268	5933905	c.178G>T/c.1422G>T	{"RYR1": {"c.178G>T": 1, "c.1422G>T": 1}}	\N
5935269	5933905	c.14471T>C/c.14693T>C	{"RYR1": {"c.14471T>C": 1, "c.14693T>C": 1}}	\N
5935270	5933905	c.7097C>G/c.11947C>T	{"RYR1": {"c.7097C>G": 1, "c.11947C>T": 1}}	\N
5935271	5933905	c.4747C>T/c.11314C>T	{"RYR1": {"c.4747C>T": 1, "c.11314C>T": 1}}	\N
5935272	5933905	c.13913G>A/c.14680G>A	{"RYR1": {"c.13913G>A": 1, "c.14680G>A": 1}}	\N
5935273	5933905	c.212C>A/c.488G>A	{"RYR1": {"c.212C>A": 1, "c.488G>A": 1}}	\N
5935274	5933905	c.9152G>A/c.11518G>A	{"RYR1": {"c.9152G>A": 1, "c.11518G>A": 1}}	\N
5935275	5933905	c.3166G>A/c.12028G>A	{"RYR1": {"c.3166G>A": 1, "c.12028G>A": 1}}	\N
5935276	5933905	c.11748T>G/c.12553G>A	{"RYR1": {"c.11748T>G": 1, "c.12553G>A": 1}}	\N
5935277	5933905	c.8654C>G/c.14471T>C	{"RYR1": {"c.8654C>G": 1, "c.14471T>C": 1}}	\N
5935278	5933905	c.1100G>A/c.7199A>G	{"RYR1": {"c.1100G>A": 1, "c.7199A>G": 1}}	\N
5935279	5933905	c.7085A>G/c.12242C>T	{"RYR1": {"c.7085A>G": 1, "c.12242C>T": 1}}	\N
5935280	5933905	c.1460T>C/c.8189A>G	{"RYR1": {"c.1460T>C": 1, "c.8189A>G": 1}}	\N
5935281	5933905	c.3172G>A/c.14678G>A	{"RYR1": {"c.3172G>A": 1, "c.14678G>A": 1}}	\N
5935282	5933905	c.6478G>A/c.10891G>T	{"RYR1": {"c.6478G>A": 1, "c.10891G>T": 1}}	\N
5935283	5933905	c.7355G>C/c.12115A>T	{"RYR1": {"c.7355G>C": 1, "c.12115A>T": 1}}	\N
5935284	5933905	c.178G>A/c.14051T>C	{"RYR1": {"c.178G>A": 1, "c.14051T>C": 1}}	\N
5935285	5933905	c.5441T>A/c.6478G>A	{"RYR1": {"c.5441T>A": 1, "c.6478G>A": 1}}	\N
5935286	5933905	c.14422_14423delinsAA/c.14680G>A	{"RYR1": {"c.14680G>A": 1, "c.14422_14423delinsAA": 1}}	\N
5935287	5933905	c.14582G>A/c.14678G>A	{"RYR1": {"c.14582G>A": 1, "c.14678G>A": 1}}	\N
5935288	5933905	c.212C>A/c.7032G>C	{"RYR1": {"c.212C>A": 1, "c.7032G>C": 1}}	\N
5935289	5933905	c.119G>C/c.641C>T	{"RYR1": {"c.119G>C": 1, "c.641C>T": 1}}	\N
5935290	5933905	c.526G>A/c.10252A>G	{"RYR1": {"c.526G>A": 1, "c.10252A>G": 1}}	\N
5935291	5933905	c.496G>A/c.497A>G	{"RYR1": {"c.496G>A": 1, "c.497A>G": 1}}	\N
5935292	5933905	c.496G>A/c.14364+1G>T	{"RYR1": {"c.496G>A": 1, "c.14364+1G>T": 1}}	\N
5935293	5933905	c.6742C>T/c.6757C>T	{"RYR1": {"c.6742C>T": 1, "c.6757C>T": 1}}	\N
5935294	5933905	c.119G>C/c.9152G>A	{"RYR1": {"c.119G>C": 1, "c.9152G>A": 1}}	\N
5935295	5933905	c.3418C>T/c.6544A>T	{"RYR1": {"c.3418C>T": 1, "c.6544A>T": 1}}	\N
5935296	5933905	c.7032G>C/c.14639T>C	{"RYR1": {"c.7032G>C": 1, "c.14639T>C": 1}}	\N
5935297	5933905	c.5440A>G/c.11126C>T	{"RYR1": {"c.5440A>G": 1, "c.11126C>T": 1}}	\N
5935298	5933905	c.10891G>T/c.11126C>T	{"RYR1": {"c.10891G>T": 1, "c.11126C>T": 1}}	\N
5935299	5933905	c.12848A>T/c.14387A>G	{"RYR1": {"c.12848A>T": 1, "c.14387A>G": 1}}	\N
5935300	5933905	c.8638G>A/c.14201G>A	{"RYR1": {"c.8638G>A": 1, "c.14201G>A": 1}}	\N
5935301	5933905	c.1598G>A/c.7787C>T	{"RYR1": {"c.1598G>A": 1, "c.7787C>T": 1}}	\N
5935302	5933905	c.7089C>G/c.11126C>T	{"RYR1": {"c.7089C>G": 1, "c.11126C>T": 1}}	\N
5935303	5933905	c.1834G>C/c.14813T>C	{"RYR1": {"c.1834G>C": 1, "c.14813T>C": 1}}	\N
5935304	5933905	c.6635T>A/c.9152G>A	{"RYR1": {"c.6635T>A": 1, "c.9152G>A": 1}}	\N
5935305	5933905	c.528G>T/c.7771C>T	{"RYR1": {"c.528G>T": 1, "c.7771C>T": 1}}	\N
5935306	5933905	c.10229C>A/c.14126C>T	{"RYR1": {"c.10229C>A": 1, "c.14126C>T": 1}}	\N
5935307	5933905	c.13702C>G/c.15060G>C	{"RYR1": {"c.13702C>G": 1, "c.15060G>C": 1}}	\N
5935308	5933905	c.528G>T/c.7097C>G	{"RYR1": {"c.528G>T": 1, "c.7097C>G": 1}}	\N
5935309	5933905	c.2122G>A/c.3656A>C	{"RYR1": {"c.2122G>A": 1, "c.3656A>C": 1}}	\N
5935310	5933905	c.3172G>A/c.13760C>T	{"RYR1": {"c.3172G>A": 1, "c.13760C>T": 1}}	\N
5935311	5933905	c.9868G>A/c.14581C>T	{"RYR1": {"c.9868G>A": 1, "c.14581C>T": 1}}	\N
5935312	5933905	c.131G>A/c.6304G>C	{"RYR1": {"c.131G>A": 1, "c.6304G>C": 1}}	\N
5935313	5933905	c.7487C>T/c.13702C>G	{"RYR1": {"c.7487C>T": 1, "c.13702C>G": 1}}	\N
5935314	5933905	c.14458G>A/c.14813T>C	{"RYR1": {"c.14458G>A": 1, "c.14813T>C": 1}}	\N
5935315	5933905	c.9868G>A/c.14678G>A	{"RYR1": {"c.9868G>A": 1, "c.14678G>A": 1}}	\N
5935316	5933905	c.467G>A/c.4775C>T	{"RYR1": {"c.467G>A": 1, "c.4775C>T": 1}}	\N
5935317	5933905	c.6847A>C/c.8198G>A	{"RYR1": {"c.6847A>C": 1, "c.8198G>A": 1}}	\N
5935318	5933905	c.9652G>A/c.11723A>T	{"RYR1": {"c.9652G>A": 1, "c.11723A>T": 1}}	\N
5935319	5933905	c.11958C>G/c.14678G>A	{"RYR1": {"c.11958C>G": 1, "c.14678G>A": 1}}	\N
5935320	5933905	c.493G>A/c.14424C>A	{"RYR1": {"c.493G>A": 1, "c.14424C>A": 1}}	\N
5935321	5933905	c.9652G>A/c.14558C>T	{"RYR1": {"c.9652G>A": 1, "c.14558C>T": 1}}	\N
5935322	5933905	c.1460T>C/c.14693T>C	{"RYR1": {"c.1460T>C": 1, "c.14693T>C": 1}}	\N
5935323	5933905	c.7317G>C/c.14680G>A	{"RYR1": {"c.7317G>C": 1, "c.14680G>A": 1}}	\N
5935324	5933905	c.1144C>A/c.9152G>A	{"RYR1": {"c.1144C>A": 1, "c.9152G>A": 1}}	\N
5935325	5933905	c.1411C>T/c.7099G>A	{"RYR1": {"c.1411C>T": 1, "c.7099G>A": 1}}	\N
5935326	5933905	c.12242C>T/c.14201G>A	{"RYR1": {"c.12242C>T": 1, "c.14201G>A": 1}}	\N
5935327	5933905	c.1834G>C/c.5440A>G	{"RYR1": {"c.1834G>C": 1, "c.5440A>G": 1}}	\N
5935328	5933905	c.496G>A/c.6544A>T	{"RYR1": {"c.496G>A": 1, "c.6544A>T": 1}}	\N
5935329	5933905	c.1411C>T/c.7018T>C	{"RYR1": {"c.1411C>T": 1, "c.7018T>C": 1}}	\N
5935330	5933905	c.3127C>T/c.14387A>G	{"RYR1": {"c.3127C>T": 1, "c.14387A>G": 1}}	\N
5935331	5933905	c.178G>A/c.10043G>A	{"RYR1": {"c.178G>A": 1, "c.10043G>A": 1}}	\N
5935332	5933905	c.5186T>G/c.10043G>A	{"RYR1": {"c.5186T>G": 1, "c.10043G>A": 1}}	\N
5935333	5933905	c.11958C>G/c.13760C>T	{"RYR1": {"c.11958C>G": 1, "c.13760C>T": 1}}	\N
5935334	5933905	c.12355A>T/c.14693T>C	{"RYR1": {"c.12355A>T": 1, "c.14693T>C": 1}}	\N
5935335	5933905	c.12413T>C/c.12533G>T	{"RYR1": {"c.12413T>C": 1, "c.12533G>T": 1}}	\N
5935336	5933905	c.1411C>T/c.14524G>A	{"RYR1": {"c.1411C>T": 1, "c.14524G>A": 1}}	\N
5935337	5933905	c.1834G>C/c.14582G>A	{"RYR1": {"c.1834G>C": 1, "c.14582G>A": 1}}	\N
5935338	5933905	c.1411C>T/c.10556C>T	{"RYR1": {"c.1411C>T": 1, "c.10556C>T": 1}}	\N
5935339	5933905	c.14051T>C/c.14126C>T	{"RYR1": {"c.14051T>C": 1, "c.14126C>T": 1}}	\N
5935340	5933905	c.1598G>A/c.9649T>C	{"RYR1": {"c.1598G>A": 1, "c.9649T>C": 1}}	\N
5935341	5933905	c.6671G>A/c.12413T>C	{"RYR1": {"c.6671G>A": 1, "c.12413T>C": 1}}	\N
5935342	5933905	c.641C>T/c.14818G>A	{"RYR1": {"c.641C>T": 1, "c.14818G>A": 1}}	\N
5935343	5933905	c.8189A>G/c.14449A>T	{"RYR1": {"c.8189A>G": 1, "c.14449A>T": 1}}	\N
5935344	5933905	c.3656A>C/c.9676G>C	{"RYR1": {"c.3656A>C": 1, "c.9676G>C": 1}}	\N
5935345	5933905	c.5186T>G/c.7771C>T	{"RYR1": {"c.5186T>G": 1, "c.7771C>T": 1}}	\N
5935346	5933905	c.641C>T/c.2654G>A	{"RYR1": {"c.641C>T": 1, "c.2654G>A": 1}}	\N
5935347	5933905	c.131G>A/c.14201G>A	{"RYR1": {"c.131G>A": 1, "c.14201G>A": 1}}	\N
5935348	5933905	c.178G>T/c.6304G>C	{"RYR1": {"c.178G>T": 1, "c.6304G>C": 1}}	\N
5935349	5933905	c.1100G>T/c.7777C>G	{"RYR1": {"c.1100G>T": 1, "c.7777C>G": 1}}	\N
5935350	5933905	c.5890C>T/c.7777C>G	{"RYR1": {"c.5890C>T": 1, "c.7777C>G": 1}}	\N
5935351	5933905	c.7112A>G/c.9758T>C	{"RYR1": {"c.7112A>G": 1, "c.9758T>C": 1}}	\N
5935352	5933905	c.7112A>G/c.11947C>T	{"RYR1": {"c.7112A>G": 1, "c.11947C>T": 1}}	\N
5935353	5933905	c.11086G>C/c.14782A>G	{"RYR1": {"c.11086G>C": 1, "c.14782A>G": 1}}	\N
5935354	5933905	c.6478G>A/c.11132C>T	{"RYR1": {"c.6478G>A": 1, "c.11132C>T": 1}}	\N
5935355	5933905	c.9152G>A/c.12121C>T	{"RYR1": {"c.9152G>A": 1, "c.12121C>T": 1}}	\N
5935356	5933905	c.5186T>G/c.7771C>G	{"RYR1": {"c.5186T>G": 1, "c.7771C>G": 1}}	\N
5935357	5933905	c.455C>A/c.12533G>T	{"RYR1": {"c.455C>A": 1, "c.12533G>T": 1}}	\N
5935358	5933905	c.3667G>A/c.8198G>A	{"RYR1": {"c.3667G>A": 1, "c.8198G>A": 1}}	\N
5935359	5933905	c.7528T>C/c.8189A>G	{"RYR1": {"c.7528T>C": 1, "c.8189A>G": 1}}	\N
5935360	5933905	c.7771C>G/c.9758T>C	{"RYR1": {"c.7771C>G": 1, "c.9758T>C": 1}}	\N
5935361	5933905	c.10891G>T/c.12355A>T	{"RYR1": {"c.10891G>T": 1, "c.12355A>T": 1}}	\N
5935362	5933905	c.680A>T/c.12355A>T	{"RYR1": {"c.680A>T": 1, "c.12355A>T": 1}}	\N
5935363	5933905	c.947G>T/c.7487C>T	{"RYR1": {"c.947G>T": 1, "c.7487C>T": 1}}	\N
5935364	5933905	c.6671G>A/c.7528T>C	{"RYR1": {"c.6671G>A": 1, "c.7528T>C": 1}}	\N
5935365	5933905	c.14270G>A/c.14693T>C	{"RYR1": {"c.14270G>A": 1, "c.14693T>C": 1}}	\N
5935366	5933905	c.5132A>G/c.6671G>A	{"RYR1": {"c.5132A>G": 1, "c.6671G>A": 1}}	\N
5935367	5933905	c.6757C>T/c.7777C>G	{"RYR1": {"c.6757C>T": 1, "c.7777C>G": 1}}	\N
5935368	5933905	c.5024T>C/c.8729C>T	{"RYR1": {"c.5024T>C": 1, "c.8729C>T": 1}}	\N
5935369	5933905	c.496G>A/c.7210G>A	{"RYR1": {"c.496G>A": 1, "c.7210G>A": 1}}	\N
5935370	5933905	c.7771C>G/c.11947C>T	{"RYR1": {"c.7771C>G": 1, "c.11947C>T": 1}}	\N
5935371	5933905	c.13913G>A/c.14424C>A	{"RYR1": {"c.13913G>A": 1, "c.14424C>A": 1}}	\N
5935372	5933905	c.947G>T/c.14197T>G	{"RYR1": {"c.947G>T": 1, "c.14197T>G": 1}}	\N
5935373	5933905	c.1553T>C/c.10237A>T	{"RYR1": {"c.1553T>C": 1, "c.10237A>T": 1}}	\N
5935374	5933905	c.5440A>G/c.12355A>T	{"RYR1": {"c.5440A>G": 1, "c.12355A>T": 1}}	\N
5935375	5933905	c.9848G>A/c.11947C>T	{"RYR1": {"c.9848G>A": 1, "c.11947C>T": 1}}	\N
5935376	5933905	c.2050G>C/c.12413T>C	{"RYR1": {"c.2050G>C": 1, "c.12413T>C": 1}}	\N
5935377	5933905	c.7089C>G/c.13934G>A	{"RYR1": {"c.7089C>G": 1, "c.13934G>A": 1}}	\N
5935378	5933905	c.5441T>A/c.14817C>A	{"RYR1": {"c.5441T>A": 1, "c.14817C>A": 1}}	\N
5935379	5933905	c.14458G>T/c.14678G>A	{"RYR1": {"c.14458G>T": 1, "c.14678G>A": 1}}	\N
5935380	5933905	c.14458G>T/c.14581C>T	{"RYR1": {"c.14458G>T": 1, "c.14581C>T": 1}}	\N
5935381	5933905	c.9676G>C/c.14186A>C	{"RYR1": {"c.9676G>C": 1, "c.14186A>C": 1}}	\N
5935382	5933905	c.488G>A/c.8926C>T	{"RYR1": {"c.488G>A": 1, "c.8926C>T": 1}}	\N
5935383	5933905	c.1024G>A/c.9797T>C	{"RYR1": {"c.1024G>A": 1, "c.9797T>C": 1}}	\N
5935384	5933905	c.496G>A/c.7522C>G	{"RYR1": {"c.496G>A": 1, "c.7522C>G": 1}}	\N
5935385	5933905	c.5024T>C/c.7778G>A	{"RYR1": {"c.5024T>C": 1, "c.7778G>A": 1}}	\N
5935386	5933905	c.178G>A/c.13994_13995delTCinsCT	{"RYR1": {"c.178G>A": 1, "c.13994_13995delTCinsCT": 1}}	\N
5935387	5933905	c.2050G>C/c.7528T>C	{"RYR1": {"c.2050G>C": 1, "c.7528T>C": 1}}	\N
5935388	5933905	c.8518C>T/c.9268G>A	{"RYR1": {"c.8518C>T": 1, "c.9268G>A": 1}}	\N
5935389	5933905	c.1598G>A/c.7089C>G	{"RYR1": {"c.1598G>A": 1, "c.7089C>G": 1}}	\N
5935390	5933905	c.10750G>C/c.11813G>A	{"RYR1": {"c.10750G>C": 1, "c.11813G>A": 1}}	\N
5935391	5933905	c.7099G>A/c.14817C>A	{"RYR1": {"c.7099G>A": 1, "c.14817C>A": 1}}	\N
5935392	5933905	c.4400A>G/c.12028G>A	{"RYR1": {"c.4400A>G": 1, "c.12028G>A": 1}}	\N
5935393	5933905	c.1411C>T/c.7085A>G	{"RYR1": {"c.1411C>T": 1, "c.7085A>G": 1}}	\N
5935394	5933905	c.1100G>A/c.14782A>G	{"RYR1": {"c.1100G>A": 1, "c.14782A>G": 1}}	\N
5935395	5933905	c.9652G>A/c.10750G>C	{"RYR1": {"c.9652G>A": 1, "c.10750G>C": 1}}	\N
5935396	5933905	c.178G>A/c.11416G>A	{"RYR1": {"c.178G>A": 1, "c.11416G>A": 1}}	\N
5935397	5933905	c.497A>G/c.6388G>A	{"RYR1": {"c.497A>G": 1, "c.6388G>A": 1}}	\N
5935398	5933905	c.7487C>T/c.9850T>A	{"RYR1": {"c.7487C>T": 1, "c.9850T>A": 1}}	\N
5935399	5933905	c.4775C>T/c.11120G>T	{"RYR1": {"c.4775C>T": 1, "c.11120G>T": 1}}	\N
5935400	5933905	c.5033A>G/c.6599C>T	{"RYR1": {"c.5033A>G": 1, "c.6599C>T": 1}}	\N
5935401	5933905	c.652G>A/c.7097C>G	{"RYR1": {"c.652G>A": 1, "c.7097C>G": 1}}	\N
5935402	5933905	c.3656A>C/c.6757C>T	{"RYR1": {"c.3656A>C": 1, "c.6757C>T": 1}}	\N
5935403	5933905	c.992_994dup/c.6757C>T	{"RYR1": {"c.6757C>T": 1, "c.992_994dup": 1}}	\N
5935404	5933905	c.5341T>C/c.14817C>A	{"RYR1": {"c.5341T>C": 1, "c.14817C>A": 1}}	\N
5935405	5933905	c.178G>A/c.6377G>A	{"RYR1": {"c.178G>A": 1, "c.6377G>A": 1}}	\N
5935406	5933905	c.12383C>T/c.14825G>T	{"RYR1": {"c.12383C>T": 1, "c.14825G>T": 1}}	\N
5935407	5933905	c.10229C>A/c.14524G>A	{"RYR1": {"c.10229C>A": 1, "c.14524G>A": 1}}	\N
5935408	5933905	c.1459C>G/c.14879T>A	{"RYR1": {"c.1459C>G": 1, "c.14879T>A": 1}}	\N
5935409	5933905	c.641C>T/c.6548G>A	{"RYR1": {"c.641C>T": 1, "c.6548G>A": 1}}	\N
5935410	5933905	c.5186T>G/c.14126C>T	{"RYR1": {"c.5186T>G": 1, "c.14126C>T": 1}}	\N
5935411	5933905	c.11314C>T/c.14825G>T	{"RYR1": {"c.11314C>T": 1, "c.14825G>T": 1}}	\N
5935412	5933905	c.9652G>A/c.12533G>T	{"RYR1": {"c.9652G>A": 1, "c.12533G>T": 1}}	\N
5935413	5933905	c.10750G>C/c.14051T>C	{"RYR1": {"c.10750G>C": 1, "c.14051T>C": 1}}	\N
5935414	5933905	c.178G>T/c.1024G>A	{"RYR1": {"c.178G>T": 1, "c.1024G>A": 1}}	\N
5935415	5933905	c.11947C>T/c.14509C>G	{"RYR1": {"c.11947C>T": 1, "c.14509C>G": 1}}	\N
5935416	5933905	c.7787C>T/c.14201G>A	{"RYR1": {"c.7787C>T": 1, "c.14201G>A": 1}}	\N
5935417	5933905	c.488G>A/c.7097C>G	{"RYR1": {"c.488G>A": 1, "c.7097C>G": 1}}	\N
5935418	5933905	c.7777C>G/c.7777C>G	{"RYR1": {"c.7777C>G": 2}}	\N
5935419	5933905	c.496G>A/c.13672C>T	{"RYR1": {"c.496G>A": 1, "c.13672C>T": 1}}	\N
5935420	5933905	c.2654G>A/c.7487C>T	{"RYR1": {"c.2654G>A": 1, "c.7487C>T": 1}}	\N
5935421	5933905	c.3095G>A/c.6743G>A	{"RYR1": {"c.3095G>A": 1, "c.6743G>A": 1}}	\N
5935422	5933905	c.7487C>T/c.8926C>T	{"RYR1": {"c.7487C>T": 1, "c.8926C>T": 1}}	\N
5935423	5933905	c.10043G>A/c.13760C>T	{"RYR1": {"c.10043G>A": 1, "c.13760C>T": 1}}	\N
5935424	5933905	c.178G>A/c.15060G>C	{"RYR1": {"c.178G>A": 1, "c.15060G>C": 1}}	\N
5935425	5933905	c.493G>A/c.12398A>G	{"RYR1": {"c.493G>A": 1, "c.12398A>G": 1}}	\N
5935426	5933905	c.2050G>C/c.13672C>T	{"RYR1": {"c.2050G>C": 1, "c.13672C>T": 1}}	\N
5935427	5933905	c.10556C>T/c.14002C>T	{"RYR1": {"c.10556C>T": 1, "c.14002C>T": 1}}	\N
5935428	5933905	c.6640G>A/c.8654C>G	{"RYR1": {"c.6640G>A": 1, "c.8654C>G": 1}}	\N
5935429	5933905	c.212C>A/c.13673G>A	{"RYR1": {"c.212C>A": 1, "c.13673G>A": 1}}	\N
5935430	5933905	c.7760A>G/c.12121C>T	{"RYR1": {"c.7760A>G": 1, "c.12121C>T": 1}}	\N
5935431	5933905	c.9850T>A/c.10237A>T	{"RYR1": {"c.9850T>A": 1, "c.10237A>T": 1}}	\N
5935432	5933905	c.6635T>A/c.7112A>G	{"RYR1": {"c.6635T>A": 1, "c.7112A>G": 1}}	\N
5935433	5933905	c.7385C>T/c.14693T>C	{"RYR1": {"c.7385C>T": 1, "c.14693T>C": 1}}	\N
5935434	5933905	c.6478G>A/c.14693T>C	{"RYR1": {"c.6478G>A": 1, "c.14693T>C": 1}}	\N
5935435	5933905	c.5341T>C/c.7032G>C	{"RYR1": {"c.5341T>C": 1, "c.7032G>C": 1}}	\N
5935436	5933905	c.7089C>G/c.14814C>G	{"RYR1": {"c.7089C>G": 1, "c.14814C>G": 1}}	\N
5935437	5933905	c.6635T>A/c.8600T>A	{"RYR1": {"c.6635T>A": 1, "c.8600T>A": 1}}	\N
5935438	5933905	c.12355A>T/c.14813T>C	{"RYR1": {"c.12355A>T": 1, "c.14813T>C": 1}}	\N
5935439	5933905	c.1201C>A/c.6304G>C	{"RYR1": {"c.1201C>A": 1, "c.6304G>C": 1}}	\N
5935440	5933905	c.6710G>A/c.12355A>T	{"RYR1": {"c.6710G>A": 1, "c.12355A>T": 1}}	\N
5935441	5933905	c.467G>A/c.11953T>C	{"RYR1": {"c.467G>A": 1, "c.11953T>C": 1}}	\N
5935442	5933905	c.2654G>A/c.6847A>C	{"RYR1": {"c.2654G>A": 1, "c.6847A>C": 1}}	\N
5935443	5933905	c.6847A>C/c.14968A>G	{"RYR1": {"c.6847A>C": 1, "c.14968A>G": 1}}	\N
5935444	5933905	c.178G>A/c.15059G>C	{"RYR1": {"c.178G>A": 1, "c.15059G>C": 1}}	\N
5935445	5933905	c.946C>T/c.10237A>T	{"RYR1": {"c.946C>T": 1, "c.10237A>T": 1}}	\N
5935446	5933905	c.7112A>G/c.9152G>A	{"RYR1": {"c.7112A>G": 1, "c.9152G>A": 1}}	\N
5935447	5933905	c.1100G>T/c.8189A>G	{"RYR1": {"c.1100G>T": 1, "c.8189A>G": 1}}	\N
5935448	5933905	c.12553G>A/c.14582G>A	{"RYR1": {"c.12553G>A": 1, "c.14582G>A": 1}}	\N
5935449	5933905	c.488G>A/c.7879G>A	{"RYR1": {"c.488G>A": 1, "c.7879G>A": 1}}	\N
5935450	5933905	c.10252A>G/c.14680G>A	{"RYR1": {"c.10252A>G": 1, "c.14680G>A": 1}}	\N
5935451	5933905	c.467G>A/c.14817C>A	{"RYR1": {"c.467G>A": 1, "c.14817C>A": 1}}	\N
5935452	5933905	c.5024T>C/c.8189A>G	{"RYR1": {"c.5024T>C": 1, "c.8189A>G": 1}}	\N
5935453	5933905	c.1459C>G/c.14051T>C	{"RYR1": {"c.1459C>G": 1, "c.14051T>C": 1}}	\N
5935454	5933905	c.3166G>A/c.9635A>G	{"RYR1": {"c.3166G>A": 1, "c.9635A>G": 1}}	\N
5935455	5933905	c.212C>A/c.12413T>C	{"RYR1": {"c.212C>A": 1, "c.12413T>C": 1}}	\N
5935456	5933905	c.9797T>C/c.14197T>G	{"RYR1": {"c.9797T>C": 1, "c.14197T>G": 1}}	\N
5935457	5933905	c.212C>A/c.8054C>T	{"RYR1": {"c.212C>A": 1, "c.8054C>T": 1}}	\N
5935458	5933905	c.178G>T/c.12115A>T	{"RYR1": {"c.178G>T": 1, "c.12115A>T": 1}}	\N
5935459	5933905	c.7073T>A/c.11314C>T	{"RYR1": {"c.7073T>A": 1, "c.11314C>T": 1}}	\N
5935460	5933905	c.6671G>A/c.14818G>A	{"RYR1": {"c.6671G>A": 1, "c.14818G>A": 1}}	\N
5935461	5933905	c.7777C>G/c.14693T>C	{"RYR1": {"c.7777C>G": 1, "c.14693T>C": 1}}	\N
5935462	5933905	c.190T>C/c.6710G>A	{"RYR1": {"c.190T>C": 1, "c.6710G>A": 1}}	\N
5935463	5933905	c.9652G>A/c.10556C>T	{"RYR1": {"c.9652G>A": 1, "c.10556C>T": 1}}	\N
5935464	5933905	c.947G>T/c.7089C>G	{"RYR1": {"c.947G>T": 1, "c.7089C>G": 1}}	\N
5935465	5933905	c.7778G>A/c.8005G>A	{"RYR1": {"c.7778G>A": 1, "c.8005G>A": 1}}	\N
5935466	5933905	c.5890C>T/c.10237A>T	{"RYR1": {"c.5890C>T": 1, "c.10237A>T": 1}}	\N
5935467	5933905	c.7487C>T/c.14471T>C	{"RYR1": {"c.7487C>T": 1, "c.14471T>C": 1}}	\N
5935468	5933905	c.5440A>G/c.7292A>T	{"RYR1": {"c.5440A>G": 1, "c.7292A>T": 1}}	\N
5935469	5933905	c.9268G>A/c.11748T>G	{"RYR1": {"c.9268G>A": 1, "c.11748T>G": 1}}	\N
5935470	5933905	c.8188G>C/c.12355A>T	{"RYR1": {"c.8188G>C": 1, "c.12355A>T": 1}}	\N
5935471	5933905	c.2924G>A/c.4775C>T	{"RYR1": {"c.2924G>A": 1, "c.4775C>T": 1}}	\N
5935472	5933905	c.496G>A/c.4747C>T	{"RYR1": {"c.496G>A": 1, "c.4747C>T": 1}}	\N
5935473	5933905	c.488G>A/c.5132A>G	{"RYR1": {"c.488G>A": 1, "c.5132A>G": 1}}	\N
5935474	5933905	c.14126C>T/c.14458G>A	{"RYR1": {"c.14126C>T": 1, "c.14458G>A": 1}}	\N
5935475	5933905	c.3418C>T/c.8188G>C	{"RYR1": {"c.3418C>T": 1, "c.8188G>C": 1}}	\N
5935476	5933905	c.7355G>C/c.13934G>A	{"RYR1": {"c.7355G>C": 1, "c.13934G>A": 1}}	\N
5935477	5933905	c.7032G>C/c.14968A>G	{"RYR1": {"c.7032G>C": 1, "c.14968A>G": 1}}	\N
5935478	5933905	c.1553T>C/c.2654G>A	{"RYR1": {"c.1553T>C": 1, "c.2654G>A": 1}}	\N
5935479	5933905	c.1460T>C/c.5440A>G	{"RYR1": {"c.1460T>C": 1, "c.5440A>G": 1}}	\N
5935480	5933905	c.8926C>T/c.14818G>A	{"RYR1": {"c.8926C>T": 1, "c.14818G>A": 1}}	\N
5935481	5933905	c.11126C>T/c.11723A>T	{"RYR1": {"c.11126C>T": 1, "c.11723A>T": 1}}	\N
5935482	5933905	c.178G>A/c.8005G>A	{"RYR1": {"c.178G>A": 1, "c.8005G>A": 1}}	\N
5935483	5933905	c.14126C>T/c.14458G>T	{"RYR1": {"c.14126C>T": 1, "c.14458G>T": 1}}	\N
5935484	5933905	c.455C>A/c.1597C>A	{"RYR1": {"c.455C>A": 1, "c.1597C>A": 1}}	\N
5935485	5933905	c.641C>T/c.5024T>C	{"RYR1": {"c.641C>T": 1, "c.5024T>C": 1}}	\N
5935486	5933905	c.7760A>G/c.14567C>G	{"RYR1": {"c.7760A>G": 1, "c.14567C>G": 1}}	\N
5935487	5933905	c.946C>T/c.6478G>A	{"RYR1": {"c.946C>T": 1, "c.6478G>A": 1}}	\N
5935488	5933905	c.526G>A/c.5024T>C	{"RYR1": {"c.526G>A": 1, "c.5024T>C": 1}}	\N
5935489	5933905	c.12115A>T/c.14680G>A	{"RYR1": {"c.12115A>T": 1, "c.14680G>A": 1}}	\N
5935490	5933905	c.5341T>C/c.9797T>C	{"RYR1": {"c.5341T>C": 1, "c.9797T>C": 1}}	\N
5935491	5933905	c.6635T>A/c.9356G>A	{"RYR1": {"c.6635T>A": 1, "c.9356G>A": 1}}	\N
5935492	5933905	c.7112A>G/c.14364+1G>T	{"RYR1": {"c.7112A>G": 1, "c.14364+1G>T": 1}}	\N
5935493	5933905	c.1597C>A/c.4400A>G	{"RYR1": {"c.1597C>A": 1, "c.4400A>G": 1}}	\N
5935494	5933905	c.1460T>C/c.14813T>C	{"RYR1": {"c.1460T>C": 1, "c.14813T>C": 1}}	\N
5935495	5933905	c.455C>A/c.3095G>A	{"RYR1": {"c.455C>A": 1, "c.3095G>A": 1}}	\N
5935496	5933905	c.467G>A/c.4763C>T	{"RYR1": {"c.467G>A": 1, "c.4763C>T": 1}}	\N
5935497	5933905	c.479A>G/c.7018T>C	{"RYR1": {"c.479A>G": 1, "c.7018T>C": 1}}	\N
5935498	5933905	c.11947C>T/c.12064A>G	{"RYR1": {"c.11947C>T": 1, "c.12064A>G": 1}}	\N
5935499	5933905	c.5186T>G/c.7085A>G	{"RYR1": {"c.5186T>G": 1, "c.7085A>G": 1}}	\N
5935500	5933905	c.677T>A/c.7075C>T	{"RYR1": {"c.677T>A": 1, "c.7075C>T": 1}}	\N
5935501	5933905	c.152C>A/c.6037A>C	{"RYR1": {"c.152C>A": 1, "c.6037A>C": 1}}	\N
5935502	5933905	c.119G>C/c.13673G>A	{"RYR1": {"c.119G>C": 1, "c.13673G>A": 1}}	\N
5935503	5933905	c.9635A>G/c.11518G>A	{"RYR1": {"c.9635A>G": 1, "c.11518G>A": 1}}	\N
5935504	5933905	c.11132C>T/c.12533G>T	{"RYR1": {"c.11132C>T": 1, "c.12533G>T": 1}}	\N
5935505	5933905	c.178G>T/c.7317G>C	{"RYR1": {"c.178G>T": 1, "c.7317G>C": 1}}	\N
5935506	5933905	c.3166G>A/c.14270G>A	{"RYR1": {"c.3166G>A": 1, "c.14270G>A": 1}}	\N
5935507	5933905	c.3418C>T/c.7522C>G	{"RYR1": {"c.3418C>T": 1, "c.7522C>G": 1}}	\N
5935508	5933905	c.3418C>T/c.9649T>C	{"RYR1": {"c.3418C>T": 1, "c.9649T>C": 1}}	\N
5935509	5933905	c.6037A>C/c.10043G>A	{"RYR1": {"c.6037A>C": 1, "c.10043G>A": 1}}	\N
5935510	5933905	c.178G>A/c.14879T>A	{"RYR1": {"c.178G>A": 1, "c.14879T>A": 1}}	\N
5935511	5933905	c.119G>C/c.2122G>A	{"RYR1": {"c.119G>C": 1, "c.2122G>A": 1}}	\N
5935512	5933905	c.3166G>A/c.11723A>T	{"RYR1": {"c.3166G>A": 1, "c.11723A>T": 1}}	\N
5935513	5933905	c.6743G>A/c.14270G>A	{"RYR1": {"c.6743G>A": 1, "c.14270G>A": 1}}	\N
5935514	5933905	c.7778G>A/c.15060G>C	{"RYR1": {"c.7778G>A": 1, "c.15060G>C": 1}}	\N
5935515	5933905	c.6548G>A/c.14387A>G	{"RYR1": {"c.6548G>A": 1, "c.14387A>G": 1}}	\N
5935516	5933905	c.8729C>T/c.14968A>G	{"RYR1": {"c.8729C>T": 1, "c.14968A>G": 1}}	\N
5935517	5933905	c.152C>A/c.13934G>A	{"RYR1": {"c.152C>A": 1, "c.13934G>A": 1}}	\N
5935518	5933905	c.1834G>C/c.6478G>A	{"RYR1": {"c.1834G>C": 1, "c.6478G>A": 1}}	\N
5935519	5933905	c.7085A>G/c.12398A>G	{"RYR1": {"c.7085A>G": 1, "c.12398A>G": 1}}	\N
5935520	5933905	c.528G>T/c.14449A>T	{"RYR1": {"c.528G>T": 1, "c.14449A>T": 1}}	\N
5935521	5933905	c.8600T>A/c.9356G>A	{"RYR1": {"c.8600T>A": 1, "c.9356G>A": 1}}	\N
5935522	5933905	c.1453A>G/c.13934G>A	{"RYR1": {"c.1453A>G": 1, "c.13934G>A": 1}}	\N
5935523	5933905	c.2924G>A/c.4763C>T	{"RYR1": {"c.2924G>A": 1, "c.4763C>T": 1}}	\N
5935524	5933905	c.479A>G/c.10043G>A	{"RYR1": {"c.479A>G": 1, "c.10043G>A": 1}}	\N
5935525	5933905	c.7317G>C/c.10750G>C	{"RYR1": {"c.7317G>C": 1, "c.10750G>C": 1}}	\N
5935526	5933905	c.7879G>A/c.10891G>T	{"RYR1": {"c.7879G>A": 1, "c.10891G>T": 1}}	\N
5935527	5933905	c.8290G>A/c.14693T>C	{"RYR1": {"c.8290G>A": 1, "c.14693T>C": 1}}	\N
5935528	5933905	c.7879G>A/c.12413T>C	{"RYR1": {"c.7879G>A": 1, "c.12413T>C": 1}}	\N
5935529	5933905	c.251C>T/c.3527C>T	{"RYR1": {"c.251C>T": 1, "c.3527C>T": 1}}	\N
5935530	5933905	c.2654G>A/c.7778G>A	{"RYR1": {"c.2654G>A": 1, "c.7778G>A": 1}}	\N
5935531	5933905	c.10556C>T/c.14693T>C	{"RYR1": {"c.10556C>T": 1, "c.14693T>C": 1}}	\N
5935532	5933905	c.1201C>G/c.14471T>C	{"RYR1": {"c.1201C>G": 1, "c.14471T>C": 1}}	\N
5935533	5933905	c.6640G>A/c.8527T>C	{"RYR1": {"c.6640G>A": 1, "c.8527T>C": 1}}	\N
5935534	5933905	c.3127C>T/c.10891G>T	{"RYR1": {"c.3127C>T": 1, "c.10891G>T": 1}}	\N
5935535	5933905	c.7879G>A/c.14422_14423delinsAA	{"RYR1": {"c.7879G>A": 1, "c.14422_14423delinsAA": 1}}	\N
5935536	5933905	c.5132A>G/c.12532G>A	{"RYR1": {"c.5132A>G": 1, "c.12532G>A": 1}}	\N
5935537	5933905	c.1475G>A/c.14197T>G	{"RYR1": {"c.1475G>A": 1, "c.14197T>G": 1}}	\N
5935538	5933905	c.7385C>T/c.14002C>T	{"RYR1": {"c.7385C>T": 1, "c.14002C>T": 1}}	\N
5935539	5933905	c.2996G>A/c.14678G>A	{"RYR1": {"c.2996G>A": 1, "c.14678G>A": 1}}	\N
5935540	5933905	c.6544A>T/c.11748T>G	{"RYR1": {"c.6544A>T": 1, "c.11748T>G": 1}}	\N
5935541	5933905	c.3667G>A/c.7089C>G	{"RYR1": {"c.3667G>A": 1, "c.7089C>G": 1}}	\N
5935542	5933905	c.2050G>C/c.3667G>A	{"RYR1": {"c.2050G>C": 1, "c.3667G>A": 1}}	\N
5935543	5933905	c.7292A>T/c.7879G>A	{"RYR1": {"c.7292A>T": 1, "c.7879G>A": 1}}	\N
5935544	5933905	c.3127C>T/c.9797T>C	{"RYR1": {"c.3127C>T": 1, "c.9797T>C": 1}}	\N
5935545	5933905	c.4400A>G/c.7879G>A	{"RYR1": {"c.4400A>G": 1, "c.7879G>A": 1}}	\N
5935546	5933905	c.455C>A/c.467G>A	{"RYR1": {"c.455C>A": 1, "c.467G>A": 1}}	\N
5935547	5933905	c.528G>T/c.10556C>T	{"RYR1": {"c.528G>T": 1, "c.10556C>T": 1}}	\N
5935548	5933905	c.1411C>T/c.14126C>T	{"RYR1": {"c.1411C>T": 1, "c.14126C>T": 1}}	\N
5935549	5933905	c.212C>A/c.14422_14423delinsAA	{"RYR1": {"c.212C>A": 1, "c.14422_14423delinsAA": 1}}	\N
5935550	5933905	c.1422G>T/c.7199A>G	{"RYR1": {"c.1422G>T": 1, "c.7199A>G": 1}}	\N
5935551	5933905	c.6548G>A/c.14002C>T	{"RYR1": {"c.6548G>A": 1, "c.14002C>T": 1}}	\N
5935552	5933905	c.8054C>T/c.14680G>A	{"RYR1": {"c.8054C>T": 1, "c.14680G>A": 1}}	\N
5935553	5933905	c.6302T>A/c.8729C>T	{"RYR1": {"c.6302T>A": 1, "c.8729C>T": 1}}	\N
5935554	5933905	c.7112A>G/c.9356G>A	{"RYR1": {"c.7112A>G": 1, "c.9356G>A": 1}}	\N
5935555	5933905	c.12121C>T/c.14458G>T	{"RYR1": {"c.12121C>T": 1, "c.14458G>T": 1}}	\N
5935556	5933905	c.10043G>A/c.14582G>A	{"RYR1": {"c.10043G>A": 1, "c.14582G>A": 1}}	\N
5935557	5933905	c.1201C>G/c.12848A>T	{"RYR1": {"c.1201C>G": 1, "c.12848A>T": 1}}	\N
5935558	5933905	c.3667G>A/c.6544A>T	{"RYR1": {"c.3667G>A": 1, "c.6544A>T": 1}}	\N
5935559	5933905	c.6478G>A/c.7777C>G	{"RYR1": {"c.6478G>A": 1, "c.7777C>G": 1}}	\N
5935560	5933905	c.8600T>A/c.8600T>A	{"RYR1": {"c.8600T>A": 2}}	\N
5908797	5908756	Roubaix	{"G6PD": {"Roubaix": 1}}	\N
5935561	5933905	c.992_994dup/c.1460T>C	{"RYR1": {"c.1460T>C": 1, "c.992_994dup": 1}}	\N
5935562	5933905	c.12848A>T/c.14813T>C	{"RYR1": {"c.12848A>T": 1, "c.14813T>C": 1}}	\N
5935563	5933905	c.13994_13995delTCinsCT/c.14558C>T	{"RYR1": {"c.14558C>T": 1, "c.13994_13995delTCinsCT": 1}}	\N
5935564	5933905	c.11947C>T/c.14558C>T	{"RYR1": {"c.11947C>T": 1, "c.14558C>T": 1}}	\N
5935565	5933905	c.5186T>G/c.9268G>A	{"RYR1": {"c.5186T>G": 1, "c.9268G>A": 1}}	\N
5935566	5933905	c.6388G>A/c.14051T>C	{"RYR1": {"c.6388G>A": 1, "c.14051T>C": 1}}	\N
5935567	5933905	c.5440A>G/c.11813G>A	{"RYR1": {"c.5440A>G": 1, "c.11813G>A": 1}}	\N
5935568	5933905	c.12121C>T/c.14458G>A	{"RYR1": {"c.12121C>T": 1, "c.14458G>A": 1}}	\N
5935569	5933905	c.5186T>G/c.7099G>A	{"RYR1": {"c.5186T>G": 1, "c.7099G>A": 1}}	\N
5935570	5933905	c.11723A>T/c.14558C>T	{"RYR1": {"c.11723A>T": 1, "c.14558C>T": 1}}	\N
5935571	5933905	c.496G>A/c.3172G>A	{"RYR1": {"c.496G>A": 1, "c.3172G>A": 1}}	\N
5935572	5933905	c.9649T>C/c.9649T>C	{"RYR1": {"c.9649T>C": 2}}	\N
5935573	5933905	c.5186T>G/c.7018T>C	{"RYR1": {"c.5186T>G": 1, "c.7018T>C": 1}}	\N
5935574	5933905	c.5132A>G/c.10891G>T	{"RYR1": {"c.5132A>G": 1, "c.10891G>T": 1}}	\N
5935575	5933905	c.5890C>T/c.11086G>C	{"RYR1": {"c.5890C>T": 1, "c.11086G>C": 1}}	\N
5935576	5933905	c.8654C>G/c.13934G>A	{"RYR1": {"c.8654C>G": 1, "c.13934G>A": 1}}	\N
5935577	5933905	c.13918A>G/c.14197T>G	{"RYR1": {"c.13918A>G": 1, "c.14197T>G": 1}}	\N
5935578	5933905	c.467G>A/c.14782A>G	{"RYR1": {"c.467G>A": 1, "c.14782A>G": 1}}	\N
5935579	5933905	c.1411C>T/c.2537C>T	{"RYR1": {"c.1411C>T": 1, "c.2537C>T": 1}}	\N
5935580	5933905	c.1024G>A/c.14817C>A	{"RYR1": {"c.1024G>A": 1, "c.14817C>A": 1}}	\N
5935581	5933905	c.51_53del/c.14567C>G	{"RYR1": {"c.14567C>G": 1, "c.51_53del": 1}}	\N
5935582	5933905	c.7528T>C/c.14002C>T	{"RYR1": {"c.7528T>C": 1, "c.14002C>T": 1}}	\N
5935583	5933905	c.152C>A/c.10042C>T	{"RYR1": {"c.152C>A": 1, "c.10042C>T": 1}}	\N
5935584	5933905	c.6743G>A/c.9635A>G	{"RYR1": {"c.6743G>A": 1, "c.9635A>G": 1}}	\N
5935585	5933905	c.6742C>T/c.7097C>G	{"RYR1": {"c.6742C>T": 1, "c.7097C>G": 1}}	\N
5935586	5933905	c.1209C>G/c.5024T>C	{"RYR1": {"c.1209C>G": 1, "c.5024T>C": 1}}	\N
5935587	5933905	c.9850T>A/c.14818G>A	{"RYR1": {"c.9850T>A": 1, "c.14818G>A": 1}}	\N
5935588	5933905	c.9652G>A/c.14449A>T	{"RYR1": {"c.9652G>A": 1, "c.14449A>T": 1}}	\N
5935589	5933905	c.8600T>A/c.9152G>A	{"RYR1": {"c.8600T>A": 1, "c.9152G>A": 1}}	\N
5935590	5933905	c.1024G>A/c.14782A>G	{"RYR1": {"c.1024G>A": 1, "c.14782A>G": 1}}	\N
5935591	5933905	c.5890C>T/c.11132C>T	{"RYR1": {"c.5890C>T": 1, "c.11132C>T": 1}}	\N
5935592	5933905	c.7317G>C/c.11314C>T	{"RYR1": {"c.7317G>C": 1, "c.11314C>T": 1}}	\N
5935593	5933905	c.13702C>G/c.14814C>G	{"RYR1": {"c.13702C>G": 1, "c.14814C>G": 1}}	\N
5935594	5933905	c.1553T>C/c.9797T>C	{"RYR1": {"c.1553T>C": 1, "c.9797T>C": 1}}	\N
5935595	5933905	c.1834G>C/c.6671G>A	{"RYR1": {"c.1834G>C": 1, "c.6671G>A": 1}}	\N
5935596	5933905	c.13673G>A/c.14424C>A	{"RYR1": {"c.13673G>A": 1, "c.14424C>A": 1}}	\N
5935597	5933905	c.7032G>C/c.13994_13995delTCinsCT	{"RYR1": {"c.7032G>C": 1, "c.13994_13995delTCinsCT": 1}}	\N
5935598	5933905	c.9268G>A/c.11953T>C	{"RYR1": {"c.9268G>A": 1, "c.11953T>C": 1}}	\N
5935599	5933905	c.455C>A/c.1209C>G	{"RYR1": {"c.455C>A": 1, "c.1209C>G": 1}}	\N
5935600	5933905	c.6635T>A/c.13994_13995delTCinsCT	{"RYR1": {"c.6635T>A": 1, "c.13994_13995delTCinsCT": 1}}	\N
5935601	5933905	c.5890C>T/c.14422_14423delinsAA	{"RYR1": {"c.5890C>T": 1, "c.14422_14423delinsAA": 1}}	\N
5935602	5933905	c.2924G>A/c.7778G>A	{"RYR1": {"c.2924G>A": 1, "c.7778G>A": 1}}	\N
5935603	5933905	c.4747C>T/c.7385C>T	{"RYR1": {"c.4747C>T": 1, "c.7385C>T": 1}}	\N
5935604	5933905	c.6377G>A/c.9356G>A	{"RYR1": {"c.6377G>A": 1, "c.9356G>A": 1}}	\N
5935605	5933905	c.6671G>A/c.13672C>T	{"RYR1": {"c.6671G>A": 1, "c.13672C>T": 1}}	\N
5935606	5933905	c.6302T>A/c.9797T>C	{"RYR1": {"c.6302T>A": 1, "c.9797T>C": 1}}	\N
5935607	5933905	c.14424C>A/c.15060G>C	{"RYR1": {"c.14424C>A": 1, "c.15060G>C": 1}}	\N
5935608	5933905	c.528G>T/c.9676G>C	{"RYR1": {"c.528G>T": 1, "c.9676G>C": 1}}	\N
5935609	5933905	c.6377G>A/c.8600T>A	{"RYR1": {"c.6377G>A": 1, "c.8600T>A": 1}}	\N
5935610	5933905	c.7075C>T/c.14581C>T	{"RYR1": {"c.7075C>T": 1, "c.14581C>T": 1}}	\N
5935611	5933905	c.4775C>T/c.12553G>A	{"RYR1": {"c.4775C>T": 1, "c.12553G>A": 1}}	\N
5935612	5933905	c.7097C>G/c.14693T>C	{"RYR1": {"c.7097C>G": 1, "c.14693T>C": 1}}	\N
5935613	5933905	c.467G>A/c.680A>T	{"RYR1": {"c.467G>A": 1, "c.680A>T": 1}}	\N
5935614	5933905	c.1024G>A/c.12121C>T	{"RYR1": {"c.1024G>A": 1, "c.12121C>T": 1}}	\N
5935615	5933905	c.5890C>T/c.12413T>C	{"RYR1": {"c.5890C>T": 1, "c.12413T>C": 1}}	\N
5935616	5933905	c.1598G>A/c.12689T>G	{"RYR1": {"c.1598G>A": 1, "c.12689T>G": 1}}	\N
5935617	5933905	c.1453A>G/c.3172G>A	{"RYR1": {"c.1453A>G": 1, "c.3172G>A": 1}}	\N
5935618	5933905	c.528G>T/c.9652G>A	{"RYR1": {"c.528G>T": 1, "c.9652G>A": 1}}	\N
5935619	5933905	c.496G>A/c.8188G>C	{"RYR1": {"c.496G>A": 1, "c.8188G>C": 1}}	\N
5935620	5933905	c.488G>A/c.496G>A	{"RYR1": {"c.488G>A": 1, "c.496G>A": 1}}	\N
5935621	5933905	c.1100G>T/c.1834G>C	{"RYR1": {"c.1100G>T": 1, "c.1834G>C": 1}}	\N
5935622	5933905	c.7522C>G/c.11126C>T	{"RYR1": {"c.7522C>G": 1, "c.11126C>T": 1}}	\N
5935623	5933905	c.1201C>A/c.14471T>C	{"RYR1": {"c.1201C>A": 1, "c.14471T>C": 1}}	\N
5935624	5933905	c.13672C>T/c.13702C>G	{"RYR1": {"c.13672C>T": 1, "c.13702C>G": 1}}	\N
5935625	5933905	c.13913G>A/c.14581C>T	{"RYR1": {"c.13913G>A": 1, "c.14581C>T": 1}}	\N
5935626	5933905	c.7317G>C/c.14558C>T	{"RYR1": {"c.7317G>C": 1, "c.14558C>T": 1}}	\N
5935627	5933905	c.8005G>A/c.10043G>A	{"RYR1": {"c.8005G>A": 1, "c.10043G>A": 1}}	\N
5935628	5933905	c.992_994dup/c.9868G>A	{"RYR1": {"c.9868G>A": 1, "c.992_994dup": 1}}	\N
5935629	5933905	c.2654G>A/c.9758T>C	{"RYR1": {"c.2654G>A": 1, "c.9758T>C": 1}}	\N
5935630	5933905	c.8198G>A/c.12028G>A	{"RYR1": {"c.8198G>A": 1, "c.12028G>A": 1}}	\N
5935631	5933905	c.13918A>G/c.14364+1G>T	{"RYR1": {"c.13918A>G": 1, "c.14364+1G>T": 1}}	\N
5935632	5933905	c.14458G>T/c.14813T>C	{"RYR1": {"c.14458G>T": 1, "c.14813T>C": 1}}	\N
5935633	5933905	c.5441T>A/c.6302T>A	{"RYR1": {"c.5441T>A": 1, "c.6302T>A": 1}}	\N
5935634	5933905	c.6548G>A/c.13760C>T	{"RYR1": {"c.6548G>A": 1, "c.13760C>T": 1}}	\N
5935635	5933905	c.625G>A/c.680A>T	{"RYR1": {"c.625G>A": 1, "c.680A>T": 1}}	\N
5935636	5933905	c.12689T>G/c.14680G>A	{"RYR1": {"c.12689T>G": 1, "c.14680G>A": 1}}	\N
5935637	5933905	c.2924G>A/c.6302T>A	{"RYR1": {"c.2924G>A": 1, "c.6302T>A": 1}}	\N
5935638	5933905	c.1411C>T/c.5341T>C	{"RYR1": {"c.1411C>T": 1, "c.5341T>C": 1}}	\N
5935639	5933905	c.14424C>A/c.15059G>C	{"RYR1": {"c.14424C>A": 1, "c.15059G>C": 1}}	\N
5935640	5933905	c.4747C>T/c.10229C>A	{"RYR1": {"c.4747C>T": 1, "c.10229C>A": 1}}	\N
5935641	5933905	c.946C>T/c.14818G>A	{"RYR1": {"c.946C>T": 1, "c.14818G>A": 1}}	\N
5935642	5933905	c.3527C>T/c.8290G>A	{"RYR1": {"c.3527C>T": 1, "c.8290G>A": 1}}	\N
5935643	5933905	c.5186T>G/c.13934G>A	{"RYR1": {"c.5186T>G": 1, "c.13934G>A": 1}}	\N
5935644	5933905	c.3172G>A/c.14387A>G	{"RYR1": {"c.3172G>A": 1, "c.14387A>G": 1}}	\N
5935645	5933905	c.4775C>T/c.7032G>C	{"RYR1": {"c.4775C>T": 1, "c.7032G>C": 1}}	\N
5935646	5933905	c.479A>G/c.9268G>A	{"RYR1": {"c.479A>G": 1, "c.9268G>A": 1}}	\N
5935647	5933905	c.3667G>A/c.7210G>A	{"RYR1": {"c.3667G>A": 1, "c.7210G>A": 1}}	\N
5935648	5933905	c.13505A>G/c.14678G>A	{"RYR1": {"c.13505A>G": 1, "c.14678G>A": 1}}	\N
5935649	5933905	c.2050G>C/c.14818G>A	{"RYR1": {"c.2050G>C": 1, "c.14818G>A": 1}}	\N
5935650	5933905	c.3656A>C/c.14524G>A	{"RYR1": {"c.3656A>C": 1, "c.14524G>A": 1}}	\N
5935651	5933905	c.178G>A/c.14201G>A	{"RYR1": {"c.178G>A": 1, "c.14201G>A": 1}}	\N
5935652	5933905	c.6710G>A/c.8527T>C	{"RYR1": {"c.6710G>A": 1, "c.8527T>C": 1}}	\N
5935653	5933905	c.1422G>T/c.1834G>C	{"RYR1": {"c.1422G>T": 1, "c.1834G>C": 1}}	\N
5935654	5933905	c.178G>T/c.10043G>A	{"RYR1": {"c.178G>T": 1, "c.10043G>A": 1}}	\N
5935655	5933905	c.4763C>T/c.6847A>C	{"RYR1": {"c.4763C>T": 1, "c.6847A>C": 1}}	\N
5935656	5933905	c.11723A>T/c.12064A>G	{"RYR1": {"c.11723A>T": 1, "c.12064A>G": 1}}	\N
5935657	5933905	c.14581C>T/c.14680G>A	{"RYR1": {"c.14581C>T": 1, "c.14680G>A": 1}}	\N
5935658	5933905	c.992_994dup/c.6640G>A	{"RYR1": {"c.6640G>A": 1, "c.992_994dup": 1}}	\N
5935659	5933905	c.13673G>A/c.14813T>C	{"RYR1": {"c.13673G>A": 1, "c.14813T>C": 1}}	\N
5935660	5933905	c.190T>C/c.7097C>G	{"RYR1": {"c.190T>C": 1, "c.7097C>G": 1}}	\N
5935661	5933905	c.119G>C/c.11958C>G	{"RYR1": {"c.119G>C": 1, "c.11958C>G": 1}}	\N
5935662	5933905	c.497A>G/c.14201G>A	{"RYR1": {"c.497A>G": 1, "c.14201G>A": 1}}	\N
5935663	5933905	c.6377G>A/c.7112A>G	{"RYR1": {"c.6377G>A": 1, "c.7112A>G": 1}}	\N
5935664	5933905	c.11723A>T/c.14509C>G	{"RYR1": {"c.11723A>T": 1, "c.14509C>G": 1}}	\N
5935665	5933905	c.677T>A/c.10043G>A	{"RYR1": {"c.677T>A": 1, "c.10043G>A": 1}}	\N
5935666	5933905	c.9652G>A/c.14509C>G	{"RYR1": {"c.9652G>A": 1, "c.14509C>G": 1}}	\N
5935667	5933905	c.6377G>A/c.14364+1G>T	{"RYR1": {"c.6377G>A": 1, "c.14364+1G>T": 1}}	\N
5935668	5933905	c.946C>T/c.8729C>T	{"RYR1": {"c.946C>T": 1, "c.8729C>T": 1}}	\N
5935669	5933905	c.14186A>C/c.14582G>A	{"RYR1": {"c.14186A>C": 1, "c.14582G>A": 1}}	\N
5935670	5933905	c.3667G>A/c.12355A>T	{"RYR1": {"c.3667G>A": 1, "c.12355A>T": 1}}	\N
5935671	5933905	c.533A>C/c.15060G>C	{"RYR1": {"c.533A>C": 1, "c.15060G>C": 1}}	\N
5935672	5933905	c.6037A>C/c.7075C>T	{"RYR1": {"c.6037A>C": 1, "c.7075C>T": 1}}	\N
5935673	5933905	c.677T>A/c.6388G>A	{"RYR1": {"c.677T>A": 1, "c.6388G>A": 1}}	\N
5935674	5933905	c.3095G>A/c.5024T>C	{"RYR1": {"c.3095G>A": 1, "c.5024T>C": 1}}	\N
5935675	5933905	c.190T>C/c.12533G>T	{"RYR1": {"c.190T>C": 1, "c.12533G>T": 1}}	\N
5935676	5933905	c.13672C>T/c.14680G>A	{"RYR1": {"c.13672C>T": 1, "c.14680G>A": 1}}	\N
5935677	5933905	c.12398A>G/c.14509C>G	{"RYR1": {"c.12398A>G": 1, "c.14509C>G": 1}}	\N
5935678	5933905	c.10556C>T/c.14387A>G	{"RYR1": {"c.10556C>T": 1, "c.14387A>G": 1}}	\N
5935679	5933905	c.12413T>C/c.14678G>A	{"RYR1": {"c.12413T>C": 1, "c.14678G>A": 1}}	\N
5935680	5933905	c.11947C>T/c.14449A>T	{"RYR1": {"c.11947C>T": 1, "c.14449A>T": 1}}	\N
5935681	5933905	c.11958C>G/c.14813T>C	{"RYR1": {"c.11958C>G": 1, "c.14813T>C": 1}}	\N
5935682	5933905	c.6599C>T/c.12121C>T	{"RYR1": {"c.6599C>T": 1, "c.12121C>T": 1}}	\N
5935683	5933905	c.652G>A/c.10750G>C	{"RYR1": {"c.652G>A": 1, "c.10750G>C": 1}}	\N
5935684	5933905	c.7075C>T/c.11723A>T	{"RYR1": {"c.7075C>T": 1, "c.11723A>T": 1}}	\N
5935685	5933905	c.652G>A/c.3527C>T	{"RYR1": {"c.652G>A": 1, "c.3527C>T": 1}}	\N
5935686	5933905	c.641C>T/c.7528T>C	{"RYR1": {"c.641C>T": 1, "c.7528T>C": 1}}	\N
5935687	5933905	c.7355G>C/c.10043G>A	{"RYR1": {"c.7355G>C": 1, "c.10043G>A": 1}}	\N
5935688	5933905	c.1834G>C/c.12532G>A	{"RYR1": {"c.1834G>C": 1, "c.12532G>A": 1}}	\N
5935689	5933905	c.2996G>A/c.6302T>A	{"RYR1": {"c.2996G>A": 1, "c.6302T>A": 1}}	\N
5935690	5933905	c.1100G>A/c.6478G>A	{"RYR1": {"c.1100G>A": 1, "c.6478G>A": 1}}	\N
5935691	5933905	c.12532G>A/c.13990T>C	{"RYR1": {"c.12532G>A": 1, "c.13990T>C": 1}}	\N
5935692	5933905	c.6304G>C/c.7771C>T	{"RYR1": {"c.6304G>C": 1, "c.7771C>T": 1}}	\N
5935693	5933905	c.1475G>A/c.12553G>A	{"RYR1": {"c.1475G>A": 1, "c.12553G>A": 1}}	\N
5935694	5933905	c.9758T>C/c.11314C>T	{"RYR1": {"c.9758T>C": 1, "c.11314C>T": 1}}	\N
5935695	5933905	c.11748T>G/c.14364+1G>T	{"RYR1": {"c.11748T>G": 1, "c.14364+1G>T": 1}}	\N
5935696	5933905	c.7292A>T/c.10556C>T	{"RYR1": {"c.7292A>T": 1, "c.10556C>T": 1}}	\N
5935697	5933905	c.1201C>A/c.6377G>A	{"RYR1": {"c.1201C>A": 1, "c.6377G>A": 1}}	\N
5935698	5933905	c.7018T>C/c.8290G>A	{"RYR1": {"c.7018T>C": 1, "c.8290G>A": 1}}	\N
5935699	5933905	c.10556C>T/c.13505A>G	{"RYR1": {"c.10556C>T": 1, "c.13505A>G": 1}}	\N
5935700	5933905	c.13672C>T/c.14186A>C	{"RYR1": {"c.13672C>T": 1, "c.14186A>C": 1}}	\N
5935701	5933905	c.1834G>C/c.11132C>T	{"RYR1": {"c.1834G>C": 1, "c.11132C>T": 1}}	\N
5935702	5933905	c.8527T>C/c.13918A>G	{"RYR1": {"c.8527T>C": 1, "c.13918A>G": 1}}	\N
5935703	5933905	c.3656A>C/c.5890C>T	{"RYR1": {"c.3656A>C": 1, "c.5890C>T": 1}}	\N
5935704	5933905	c.1475G>A/c.9499C>T	{"RYR1": {"c.1475G>A": 1, "c.9499C>T": 1}}	\N
5935705	5933905	c.251C>T/c.2537C>T	{"RYR1": {"c.251C>T": 1, "c.2537C>T": 1}}	\N
5935706	5933905	c.2050G>C/c.9649T>C	{"RYR1": {"c.2050G>C": 1, "c.9649T>C": 1}}	\N
5935707	5933905	c.6304G>C/c.7771C>G	{"RYR1": {"c.6304G>C": 1, "c.7771C>G": 1}}	\N
5935708	5933905	c.533A>C/c.15059G>C	{"RYR1": {"c.533A>C": 1, "c.15059G>C": 1}}	\N
5935709	5933905	c.8654C>G/c.9850T>A	{"RYR1": {"c.8654C>G": 1, "c.9850T>A": 1}}	\N
5935710	5933905	c.4763C>T/c.11953T>C	{"RYR1": {"c.4763C>T": 1, "c.11953T>C": 1}}	\N
5935711	5933905	c.1100G>T/c.12121C>T	{"RYR1": {"c.1100G>T": 1, "c.12121C>T": 1}}	\N
5935712	5933905	c.11126C>T/c.13702C>G	{"RYR1": {"c.11126C>T": 1, "c.13702C>G": 1}}	\N
5935713	5933905	c.9649T>C/c.13673G>A	{"RYR1": {"c.9649T>C": 1, "c.13673G>A": 1}}	\N
5935714	5933905	c.641C>T/c.1459C>G	{"RYR1": {"c.641C>T": 1, "c.1459C>G": 1}}	\N
5935715	5933905	c.9356G>A/c.11748T>G	{"RYR1": {"c.9356G>A": 1, "c.11748T>G": 1}}	\N
5935716	5933905	c.8198G>A/c.14680G>A	{"RYR1": {"c.8198G>A": 1, "c.14680G>A": 1}}	\N
5935717	5933905	c.3527C>T/c.11314C>T	{"RYR1": {"c.3527C>T": 1, "c.11314C>T": 1}}	\N
5935718	5933905	c.1411C>T/c.9850T>A	{"RYR1": {"c.1411C>T": 1, "c.9850T>A": 1}}	\N
5935719	5933905	c.7099G>A/c.14693T>C	{"RYR1": {"c.7099G>A": 1, "c.14693T>C": 1}}	\N
5935720	5933905	c.3095G>A/c.5440A>G	{"RYR1": {"c.3095G>A": 1, "c.5440A>G": 1}}	\N
5935721	5933905	c.9652G>A/c.9868G>A	{"RYR1": {"c.9652G>A": 1, "c.9868G>A": 1}}	\N
5935722	5933905	c.11518G>A/c.12383C>T	{"RYR1": {"c.11518G>A": 1, "c.12383C>T": 1}}	\N
5935723	5933905	c.6742C>T/c.7879G>A	{"RYR1": {"c.6742C>T": 1, "c.7879G>A": 1}}	\N
5935724	5933905	c.14567C>G/c.14693T>C	{"RYR1": {"c.14567C>G": 1, "c.14693T>C": 1}}	\N
5935725	5933905	c.7487C>T/c.14879T>A	{"RYR1": {"c.7487C>T": 1, "c.14879T>A": 1}}	\N
5935726	5933905	c.493G>A/c.5033A>G	{"RYR1": {"c.493G>A": 1, "c.5033A>G": 1}}	\N
5935727	5933905	c.6671G>A/c.9649T>C	{"RYR1": {"c.6671G>A": 1, "c.9649T>C": 1}}	\N
5935728	5933905	c.2122G>A/c.3127C>T	{"RYR1": {"c.2122G>A": 1, "c.3127C>T": 1}}	\N
5935729	5933905	c.1209C>G/c.14002C>T	{"RYR1": {"c.1209C>G": 1, "c.14002C>T": 1}}	\N
5935730	5933905	c.12242C>T/c.14968A>G	{"RYR1": {"c.12242C>T": 1, "c.14968A>G": 1}}	\N
5935731	5933905	c.3656A>C/c.8926C>T	{"RYR1": {"c.3656A>C": 1, "c.8926C>T": 1}}	\N
5935732	5933905	c.2537C>T/c.5132A>G	{"RYR1": {"c.2537C>T": 1, "c.5132A>G": 1}}	\N
5935733	5933905	c.7355G>A/c.10043G>A	{"RYR1": {"c.7355G>A": 1, "c.10043G>A": 1}}	\N
5935734	5933905	c.10237A>T/c.13913G>A	{"RYR1": {"c.10237A>T": 1, "c.13913G>A": 1}}	\N
5935735	5933905	c.7085A>G/c.14002C>T	{"RYR1": {"c.7085A>G": 1, "c.14002C>T": 1}}	\N
5935736	5933905	c.2654G>A/c.14817C>A	{"RYR1": {"c.2654G>A": 1, "c.14817C>A": 1}}	\N
5935737	5933905	c.992_994dup/c.6710G>A	{"RYR1": {"c.6710G>A": 1, "c.992_994dup": 1}}	\N
5935738	5933905	c.1100G>A/c.14818G>A	{"RYR1": {"c.1100G>A": 1, "c.14818G>A": 1}}	\N
5935739	5933905	c.8198G>A/c.14186A>C	{"RYR1": {"c.8198G>A": 1, "c.14186A>C": 1}}	\N
5935740	5933905	c.4400A>G/c.7097C>G	{"RYR1": {"c.4400A>G": 1, "c.7097C>G": 1}}	\N
5935741	5933905	c.5890C>T/c.6671G>A	{"RYR1": {"c.5890C>T": 1, "c.6671G>A": 1}}	\N
5935742	5933905	c.680A>T/c.4747C>T	{"RYR1": {"c.680A>T": 1, "c.4747C>T": 1}}	\N
5935743	5933905	c.178G>A/c.1422G>T	{"RYR1": {"c.178G>A": 1, "c.1422G>T": 1}}	\N
5935744	5933905	c.2537C>T/c.7879G>A	{"RYR1": {"c.2537C>T": 1, "c.7879G>A": 1}}	\N
5935745	5933905	c.51_53del/c.8189A>G	{"RYR1": {"c.8189A>G": 1, "c.51_53del": 1}}	\N
5935746	5933905	c.12413T>C/c.14270G>A	{"RYR1": {"c.12413T>C": 1, "c.14270G>A": 1}}	\N
5935747	5933905	c.2122G>A/c.9635A>G	{"RYR1": {"c.2122G>A": 1, "c.9635A>G": 1}}	\N
5935748	5933905	c.493G>A/c.946C>T	{"RYR1": {"c.493G>A": 1, "c.946C>T": 1}}	\N
5935749	5933905	c.7307G>A/c.14471T>C	{"RYR1": {"c.7307G>A": 1, "c.14471T>C": 1}}	\N
5935750	5933905	c.11723A>T/c.14449A>T	{"RYR1": {"c.11723A>T": 1, "c.14449A>T": 1}}	\N
5935751	5933905	c.6478G>A/c.10252A>G	{"RYR1": {"c.6478G>A": 1, "c.10252A>G": 1}}	\N
5935752	5933905	c.119G>C/c.13994_13995delTCinsCT	{"RYR1": {"c.119G>C": 1, "c.13994_13995delTCinsCT": 1}}	\N
5935753	5933905	c.13918A>G/c.14639T>C	{"RYR1": {"c.13918A>G": 1, "c.14639T>C": 1}}	\N
5935754	5933905	c.11120G>T/c.11748T>G	{"RYR1": {"c.11120G>T": 1, "c.11748T>G": 1}}	\N
5935755	5933905	c.533A>C/c.12848A>T	{"RYR1": {"c.533A>C": 1, "c.12848A>T": 1}}	\N
5935756	5933905	c.9868G>A/c.14387A>G	{"RYR1": {"c.9868G>A": 1, "c.14387A>G": 1}}	\N
5935757	5933905	c.1475G>A/c.4400A>G	{"RYR1": {"c.1475G>A": 1, "c.4400A>G": 1}}	\N
5935758	5933905	c.7778G>A/c.12689T>G	{"RYR1": {"c.7778G>A": 1, "c.12689T>G": 1}}	\N
5935759	5933905	c.1459C>G/c.12355A>T	{"RYR1": {"c.1459C>G": 1, "c.12355A>T": 1}}	\N
5935760	5933905	c.3656A>C/c.5341T>C	{"RYR1": {"c.3656A>C": 1, "c.5341T>C": 1}}	\N
5935761	5933905	c.8189A>G/c.9268G>A	{"RYR1": {"c.8189A>G": 1, "c.9268G>A": 1}}	\N
5935762	5933905	c.6377G>A/c.9499C>T	{"RYR1": {"c.6377G>A": 1, "c.9499C>T": 1}}	\N
5935763	5933905	c.1201C>G/c.6640G>A	{"RYR1": {"c.1201C>G": 1, "c.6640G>A": 1}}	\N
5935764	5933905	c.131G>A/c.14471T>C	{"RYR1": {"c.131G>A": 1, "c.14471T>C": 1}}	\N
5935765	5933905	c.3667G>A/c.7760A>G	{"RYR1": {"c.3667G>A": 1, "c.7760A>G": 1}}	\N
5935766	5933905	c.9649T>C/c.13672C>T	{"RYR1": {"c.9649T>C": 1, "c.13672C>T": 1}}	\N
5935767	5933905	c.178G>T/c.8005G>A	{"RYR1": {"c.178G>T": 1, "c.8005G>A": 1}}	\N
5935768	5933905	c.212C>A/c.8188G>C	{"RYR1": {"c.212C>A": 1, "c.8188G>C": 1}}	\N
5935769	5933905	c.528G>T/c.6710G>A	{"RYR1": {"c.528G>T": 1, "c.6710G>A": 1}}	\N
5935770	5933905	c.625G>A/c.11953T>C	{"RYR1": {"c.625G>A": 1, "c.11953T>C": 1}}	\N
5935771	5933905	c.10556C>T/c.13760C>T	{"RYR1": {"c.10556C>T": 1, "c.13760C>T": 1}}	\N
5935772	5933905	c.6757C>T/c.7778G>A	{"RYR1": {"c.6757C>T": 1, "c.7778G>A": 1}}	\N
5935773	5933905	c.6742C>T/c.14186A>C	{"RYR1": {"c.6742C>T": 1, "c.14186A>C": 1}}	\N
5935774	5933905	c.212C>A/c.7355G>A	{"RYR1": {"c.212C>A": 1, "c.7355G>A": 1}}	\N
5935775	5933905	c.7777C>G/c.9758T>C	{"RYR1": {"c.7777C>G": 1, "c.9758T>C": 1}}	\N
5935776	5933905	c.212C>A/c.7355G>C	{"RYR1": {"c.212C>A": 1, "c.7355G>C": 1}}	\N
5935777	5933905	c.4747C>T/c.14509C>G	{"RYR1": {"c.4747C>T": 1, "c.14509C>G": 1}}	\N
5935778	5933905	c.1475G>A/c.7210G>A	{"RYR1": {"c.1475G>A": 1, "c.7210G>A": 1}}	\N
5935779	5933905	c.7879G>A/c.11120G>T	{"RYR1": {"c.7879G>A": 1, "c.11120G>T": 1}}	\N
5935780	5933905	c.251C>T/c.13918A>G	{"RYR1": {"c.251C>T": 1, "c.13918A>G": 1}}	\N
5935781	5933905	c.9649T>C/c.14814C>G	{"RYR1": {"c.9649T>C": 1, "c.14814C>G": 1}}	\N
5935782	5933905	c.1453A>G/c.14201G>A	{"RYR1": {"c.1453A>G": 1, "c.14201G>A": 1}}	\N
5935783	5933905	c.7073T>A/c.7879G>A	{"RYR1": {"c.7073T>A": 1, "c.7879G>A": 1}}	\N
5935784	5933905	c.12028G>A/c.12553G>A	{"RYR1": {"c.12028G>A": 1, "c.12553G>A": 1}}	\N
5935785	5933905	c.190T>C/c.10556C>T	{"RYR1": {"c.190T>C": 1, "c.10556C>T": 1}}	\N
5935786	5933905	c.8054C>T/c.11723A>T	{"RYR1": {"c.8054C>T": 1, "c.11723A>T": 1}}	\N
5935787	5933905	c.6377G>A/c.7089C>G	{"RYR1": {"c.6377G>A": 1, "c.7089C>G": 1}}	\N
5935788	5933905	c.8518C>T/c.14471T>C	{"RYR1": {"c.8518C>T": 1, "c.14471T>C": 1}}	\N
5935789	5933905	c.11314C>T/c.14449A>T	{"RYR1": {"c.11314C>T": 1, "c.14449A>T": 1}}	\N
5935790	5933905	c.7879G>A/c.10237A>T	{"RYR1": {"c.7879G>A": 1, "c.10237A>T": 1}}	\N
5935791	5933905	c.625G>A/c.14693T>C	{"RYR1": {"c.625G>A": 1, "c.14693T>C": 1}}	\N
5935792	5933905	c.2996G>A/c.8290G>A	{"RYR1": {"c.2996G>A": 1, "c.8290G>A": 1}}	\N
5935793	5933905	c.680A>T/c.8654C>G	{"RYR1": {"c.680A>T": 1, "c.8654C>G": 1}}	\N
5935794	5933905	c.1100G>T/c.14782A>G	{"RYR1": {"c.1100G>T": 1, "c.14782A>G": 1}}	\N
5935795	5933905	c.7771C>G/c.14197T>G	{"RYR1": {"c.7771C>G": 1, "c.14197T>G": 1}}	\N
5935796	5933905	c.992_994dup/c.12064A>G	{"RYR1": {"c.12064A>G": 1, "c.992_994dup": 1}}	\N
5935797	5933905	c.178G>A/c.7317G>C	{"RYR1": {"c.178G>A": 1, "c.7317G>C": 1}}	\N
5935798	5933905	c.947G>T/c.9152G>A	{"RYR1": {"c.947G>T": 1, "c.9152G>A": 1}}	\N
5935799	5933905	c.2996G>A/c.14270G>A	{"RYR1": {"c.2996G>A": 1, "c.14270G>A": 1}}	\N
5935800	5933905	c.2050G>C/c.4775C>T	{"RYR1": {"c.2050G>C": 1, "c.4775C>T": 1}}	\N
5935801	5933905	c.51_53del/c.212C>A	{"RYR1": {"c.212C>A": 1, "c.51_53del": 1}}	\N
5935802	5933905	c.1201C>A/c.5441T>A	{"RYR1": {"c.1201C>A": 1, "c.5441T>A": 1}}	\N
5935803	5933905	c.1024G>A/c.1834G>C	{"RYR1": {"c.1024G>A": 1, "c.1834G>C": 1}}	\N
5908798	5908756	Santa Maria	{"G6PD": {"Santa Maria": 1}}	\N
5935804	5933905	c.212C>A/c.9649T>C	{"RYR1": {"c.212C>A": 1, "c.9649T>C": 1}}	\N
5935805	5933905	c.1100G>T/c.7778G>A	{"RYR1": {"c.1100G>T": 1, "c.7778G>A": 1}}	\N
5935806	5933905	c.1475G>A/c.6544A>T	{"RYR1": {"c.1475G>A": 1, "c.6544A>T": 1}}	\N
5935807	5933905	c.119G>C/c.7112A>G	{"RYR1": {"c.119G>C": 1, "c.7112A>G": 1}}	\N
5935808	5933905	c.3172G>A/c.13505A>G	{"RYR1": {"c.3172G>A": 1, "c.13505A>G": 1}}	\N
5935809	5933905	c.3418C>T/c.13673G>A	{"RYR1": {"c.3418C>T": 1, "c.13673G>A": 1}}	\N
5935810	5933905	c.7307G>A/c.13994_13995delTCinsCT	{"RYR1": {"c.7307G>A": 1, "c.13994_13995delTCinsCT": 1}}	\N
5935811	5933905	c.8005G>A/c.15060G>C	{"RYR1": {"c.8005G>A": 1, "c.15060G>C": 1}}	\N
5935812	5933905	c.493G>A/c.947G>T	{"RYR1": {"c.493G>A": 1, "c.947G>T": 1}}	\N
5935813	5933905	c.51_53del/c.6671G>A	{"RYR1": {"c.6671G>A": 1, "c.51_53del": 1}}	\N
5935814	5933905	c.6544A>T/c.13913G>A	{"RYR1": {"c.6544A>T": 1, "c.13913G>A": 1}}	\N
5935815	5933905	c.10229C>A/c.13918A>G	{"RYR1": {"c.10229C>A": 1, "c.13918A>G": 1}}	\N
5935816	5933905	c.12064A>G/c.13702C>G	{"RYR1": {"c.12064A>G": 1, "c.13702C>G": 1}}	\N
5935817	5933905	c.528G>T/c.14825G>T	{"RYR1": {"c.528G>T": 1, "c.14825G>T": 1}}	\N
5935818	5933905	c.6671G>A/c.14458G>A	{"RYR1": {"c.6671G>A": 1, "c.14458G>A": 1}}	\N
5935819	5933905	c.1201C>G/c.6377G>A	{"RYR1": {"c.1201C>G": 1, "c.6377G>A": 1}}	\N
5935820	5933905	c.3172G>A/c.11314C>T	{"RYR1": {"c.3172G>A": 1, "c.11314C>T": 1}}	\N
5935821	5933905	c.4763C>T/c.14693T>C	{"RYR1": {"c.4763C>T": 1, "c.14693T>C": 1}}	\N
5935822	5933905	c.7771C>T/c.14422_14423delinsAA	{"RYR1": {"c.7771C>T": 1, "c.14422_14423delinsAA": 1}}	\N
5935823	5933905	c.533A>C/c.6304G>C	{"RYR1": {"c.533A>C": 1, "c.6304G>C": 1}}	\N
5935824	5933905	c.10252A>G/c.11723A>T	{"RYR1": {"c.10252A>G": 1, "c.11723A>T": 1}}	\N
5935825	5933905	c.14002C>T/c.14364+1G>T	{"RYR1": {"c.14002C>T": 1, "c.14364+1G>T": 1}}	\N
5935826	5933905	c.1553T>C/c.7032G>C	{"RYR1": {"c.1553T>C": 1, "c.7032G>C": 1}}	\N
5935827	5933905	c.488G>A/c.6640G>A	{"RYR1": {"c.488G>A": 1, "c.6640G>A": 1}}	\N
5935828	5933905	c.528G>T/c.13918A>G	{"RYR1": {"c.528G>T": 1, "c.13918A>G": 1}}	\N
5935829	5933905	c.6388G>A/c.7210G>A	{"RYR1": {"c.6388G>A": 1, "c.7210G>A": 1}}	\N
5935830	5933905	c.9652G>A/c.12064A>G	{"RYR1": {"c.9652G>A": 1, "c.12064A>G": 1}}	\N
5935831	5933905	c.6671G>A/c.14458G>T	{"RYR1": {"c.6671G>A": 1, "c.14458G>T": 1}}	\N
5935832	5933905	c.497A>G/c.7085A>G	{"RYR1": {"c.497A>G": 1, "c.7085A>G": 1}}	\N
5935833	5933905	c.493G>A/c.11518G>A	{"RYR1": {"c.493G>A": 1, "c.11518G>A": 1}}	\N
5935834	5933905	c.8654C>G/c.10042C>T	{"RYR1": {"c.8654C>G": 1, "c.10042C>T": 1}}	\N
5935835	5933905	c.7199A>G/c.8518C>T	{"RYR1": {"c.7199A>G": 1, "c.8518C>T": 1}}	\N
5935836	5933905	c.10043G>A/c.12533G>T	{"RYR1": {"c.10043G>A": 1, "c.12533G>T": 1}}	\N
5935837	5933905	c.1598G>A/c.8527T>C	{"RYR1": {"c.1598G>A": 1, "c.8527T>C": 1}}	\N
5935838	5933905	c.3527C>T/c.6599C>T	{"RYR1": {"c.3527C>T": 1, "c.6599C>T": 1}}	\N
5935839	5933905	c.1100G>T/c.6671G>A	{"RYR1": {"c.1100G>T": 1, "c.6671G>A": 1}}	\N
5935840	5933905	c.6710G>A/c.8654C>G	{"RYR1": {"c.6710G>A": 1, "c.8654C>G": 1}}	\N
5935841	5933905	c.190T>C/c.6757C>T	{"RYR1": {"c.190T>C": 1, "c.6757C>T": 1}}	\N
5935842	5933905	c.178G>A/c.12848A>T	{"RYR1": {"c.178G>A": 1, "c.12848A>T": 1}}	\N
5935843	5933905	c.7771C>T/c.12413T>C	{"RYR1": {"c.7771C>T": 1, "c.12413T>C": 1}}	\N
5935844	5933905	c.152C>A/c.7099G>A	{"RYR1": {"c.152C>A": 1, "c.7099G>A": 1}}	\N
5935845	5933905	c.8729C>T/c.14449A>T	{"RYR1": {"c.8729C>T": 1, "c.14449A>T": 1}}	\N
5935846	5933905	c.8638G>A/c.11126C>T	{"RYR1": {"c.8638G>A": 1, "c.11126C>T": 1}}	\N
5935847	5933905	c.5890C>T/c.8729C>T	{"RYR1": {"c.5890C>T": 1, "c.8729C>T": 1}}	\N
5935848	5933905	c.5341T>C/c.14422_14423delinsAA	{"RYR1": {"c.5341T>C": 1, "c.14422_14423delinsAA": 1}}	\N
5935849	5933905	c.947G>T/c.9758T>C	{"RYR1": {"c.947G>T": 1, "c.9758T>C": 1}}	\N
5935850	5933905	c.9850T>A/c.12413T>C	{"RYR1": {"c.9850T>A": 1, "c.12413T>C": 1}}	\N
5935851	5933905	c.9868G>A/c.13505A>G	{"RYR1": {"c.9868G>A": 1, "c.13505A>G": 1}}	\N
5935852	5933905	c.3418C>T/c.8054C>T	{"RYR1": {"c.3418C>T": 1, "c.8054C>T": 1}}	\N
5935853	5933905	c.947G>T/c.4400A>G	{"RYR1": {"c.947G>T": 1, "c.4400A>G": 1}}	\N
5935854	5933905	c.8189A>G/c.10750G>C	{"RYR1": {"c.8189A>G": 1, "c.10750G>C": 1}}	\N
5935855	5933905	c.12383C>T/c.13934G>A	{"RYR1": {"c.12383C>T": 1, "c.13934G>A": 1}}	\N
5935856	5933905	c.9850T>A/c.14422_14423delinsAA	{"RYR1": {"c.9850T>A": 1, "c.14422_14423delinsAA": 1}}	\N
5935857	5933905	c.5341T>C/c.12413T>C	{"RYR1": {"c.5341T>C": 1, "c.12413T>C": 1}}	\N
5935858	5933905	c.6599C>T/c.14813T>C	{"RYR1": {"c.6599C>T": 1, "c.14813T>C": 1}}	\N
5935859	5933905	c.7112A>G/c.7307G>A	{"RYR1": {"c.7112A>G": 1, "c.7307G>A": 1}}	\N
5935860	5933905	c.11958C>G/c.13505A>G	{"RYR1": {"c.11958C>G": 1, "c.13505A>G": 1}}	\N
5935861	5933905	c.5033A>G/c.12532G>A	{"RYR1": {"c.5033A>G": 1, "c.12532G>A": 1}}	\N
5935862	5933905	c.9268G>A/c.12383C>T	{"RYR1": {"c.9268G>A": 1, "c.12383C>T": 1}}	\N
5935863	5933905	c.5024T>C/c.14818G>A	{"RYR1": {"c.5024T>C": 1, "c.14818G>A": 1}}	\N
5935864	5933905	c.131G>A/c.4747C>T	{"RYR1": {"c.131G>A": 1, "c.4747C>T": 1}}	\N
5935865	5933905	c.8518C>T/c.10043G>A	{"RYR1": {"c.8518C>T": 1, "c.10043G>A": 1}}	\N
5935866	5933905	c.5441T>A/c.14782A>G	{"RYR1": {"c.5441T>A": 1, "c.14782A>G": 1}}	\N
5935867	5933905	c.526G>A/c.14813T>C	{"RYR1": {"c.526G>A": 1, "c.14813T>C": 1}}	\N
5935868	5933905	c.3656A>C/c.14680G>A	{"RYR1": {"c.3656A>C": 1, "c.14680G>A": 1}}	\N
5935869	5933905	c.1201C>G/c.15060G>C	{"RYR1": {"c.1201C>G": 1, "c.15060G>C": 1}}	\N
5935870	5933905	c.5024T>C/c.10237A>T	{"RYR1": {"c.5024T>C": 1, "c.10237A>T": 1}}	\N
5935871	5933905	c.6757C>T/c.14817C>A	{"RYR1": {"c.6757C>T": 1, "c.14817C>A": 1}}	\N
5935872	5933905	c.7522C>G/c.9850T>A	{"RYR1": {"c.7522C>G": 1, "c.9850T>A": 1}}	\N
5935873	5933905	c.11723A>T/c.12533G>T	{"RYR1": {"c.11723A>T": 1, "c.12533G>T": 1}}	\N
5935874	5933905	c.1144C>A/c.12553G>A	{"RYR1": {"c.1144C>A": 1, "c.12553G>A": 1}}	\N
5935875	5933905	c.152C>A/c.10043G>A	{"RYR1": {"c.152C>A": 1, "c.10043G>A": 1}}	\N
5935876	5933905	c.1201C>G/c.15059G>C	{"RYR1": {"c.1201C>G": 1, "c.15059G>C": 1}}	\N
5935877	5933905	c.992_994dup/c.14449A>T	{"RYR1": {"c.14449A>T": 1, "c.992_994dup": 1}}	\N
5935878	5933905	c.1453A>G/c.8527T>C	{"RYR1": {"c.1453A>G": 1, "c.8527T>C": 1}}	\N
5935879	5933905	c.12115A>T/c.13760C>T	{"RYR1": {"c.12115A>T": 1, "c.13760C>T": 1}}	\N
5935880	5933905	c.3656A>C/c.14186A>C	{"RYR1": {"c.3656A>C": 1, "c.14186A>C": 1}}	\N
5935881	5933905	c.14197T>G/c.14680G>A	{"RYR1": {"c.14197T>G": 1, "c.14680G>A": 1}}	\N
5935882	5933905	c.8188G>C/c.8198G>A	{"RYR1": {"c.8188G>C": 1, "c.8198G>A": 1}}	\N
5935883	5933905	c.3095G>A/c.11518G>A	{"RYR1": {"c.3095G>A": 1, "c.11518G>A": 1}}	\N
5935884	5933905	c.178G>A/c.1024G>A	{"RYR1": {"c.178G>A": 1, "c.1024G>A": 1}}	\N
5935885	5933905	c.7032G>C/c.8198G>A	{"RYR1": {"c.7032G>C": 1, "c.8198G>A": 1}}	\N
5935886	5933905	c.1100G>A/c.11132C>T	{"RYR1": {"c.1100G>A": 1, "c.11132C>T": 1}}	\N
5935887	5933905	c.9850T>A/c.11958C>G	{"RYR1": {"c.9850T>A": 1, "c.11958C>G": 1}}	\N
5935888	5933905	c.7771C>T/c.12553G>A	{"RYR1": {"c.7771C>T": 1, "c.12553G>A": 1}}	\N
5935889	5933905	c.5132A>G/c.9797T>C	{"RYR1": {"c.5132A>G": 1, "c.9797T>C": 1}}	\N
5935890	5933905	c.497A>G/c.7099G>A	{"RYR1": {"c.497A>G": 1, "c.7099G>A": 1}}	\N
5935891	5933905	c.178G>T/c.15060G>C	{"RYR1": {"c.178G>T": 1, "c.15060G>C": 1}}	\N
5935892	5933905	c.625G>A/c.5024T>C	{"RYR1": {"c.625G>A": 1, "c.5024T>C": 1}}	\N
5935893	5933905	c.13760C>T/c.14186A>C	{"RYR1": {"c.13760C>T": 1, "c.14186A>C": 1}}	\N
5935894	5933905	c.190T>C/c.1597C>A	{"RYR1": {"c.190T>C": 1, "c.1597C>A": 1}}	\N
5935895	5933905	c.2924G>A/c.6847A>C	{"RYR1": {"c.2924G>A": 1, "c.6847A>C": 1}}	\N
5935896	5933905	c.251C>T/c.8638G>A	{"RYR1": {"c.251C>T": 1, "c.8638G>A": 1}}	\N
5935897	5933905	c.10042C>T/c.14825G>T	{"RYR1": {"c.10042C>T": 1, "c.14825G>T": 1}}	\N
5935898	5933905	c.14186A>C/c.14581C>T	{"RYR1": {"c.14186A>C": 1, "c.14581C>T": 1}}	\N
5935899	5933905	c.9676G>C/c.14558C>T	{"RYR1": {"c.9676G>C": 1, "c.14558C>T": 1}}	\N
5935900	5933905	c.212C>A/c.7112A>G	{"RYR1": {"c.212C>A": 1, "c.7112A>G": 1}}	\N
5935901	5933905	c.7760A>G/c.8189A>G	{"RYR1": {"c.7760A>G": 1, "c.8189A>G": 1}}	\N
