SLCO1B1*9 is assigned no function based on in vitro studies demonstrating reduced uptake of estrone sulfate, estradiol 17beta-d-glucuronide, rifampin, rosuvastatin and atrasentan (11477075, 12490595, 16697742, 16513443) but normal protein expression (33658230). One clinical study of 1 heterozygous carrier of *31 (has same G488A variant) showed markedly decreased high-dose methotrexate clearance compared to wildtype, slower than a *5/*5 patient (22147369). Therefore, consensus among experts was no function due to limited evidence.