CYP2D6*29x2 is assigned normal function based on limited evidence. CYP2D6*29 is assigned decreased function based on subjects demonstrating decreased enzyme activity with various substrates (11470994, 11823760). Therefore, consensus among experts was normal function with an activity value of 1 based on limited evidence as it was determined the phenotypes containing a duplication of this allele would demonstrate greater enzyme activity than that of the nonduplicated allele and be clinically similar to phenotypes comprising normal function alleles.